Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionubiquitin-like ligase-substrate adaptor activity

PRAMEF9 PRAMEF19 PRAMEF15 PRAMEF4 PRAMEF27 PRAME

1.09e-0682826GO:1990756
GeneOntologyMolecularFunctionenzyme-substrate adaptor activity

PRAMEF9 PRAMEF19 PRAMEF15 PRAMEF4 PRAMEF27 PRAME

2.59e-0695826GO:0140767
GeneOntologyMolecularFunctionnuclear retinoic acid receptor binding

PRAMEF19 PRAMEF15 PRAMEF4 PRAMEF27 PRAME

3.06e-0655825GO:0042974
GeneOntologyMolecularFunctionacetylcholine receptor activity

CHRNA1 CHRNB2 HRH3

1.11e-0423823GO:0015464
GeneOntologyMolecularFunctionnuclear receptor binding

PRAMEF19 PRAMEF15 PRAMEF4 SLC30A9 PRAMEF27 PRAME

1.21e-04187826GO:0016922
GeneOntologyMolecularFunctionmicrofilament motor activity

MYH8 MYO1A MYH15

5.08e-0438823GO:0000146
GeneOntologyMolecularFunctiontransmembrane transporter activity

SLC7A9 CNNM4 NALF1 TRPC1 SCN10A SLC30A9 KCNT1 CHRNA1 SLC38A6 CHRNB2 RHCE RHD SLC30A6

9.93e-0411808213GO:0022857
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

CNNM4 NALF1 TRPC1 SCN10A SLC30A9 KCNT1 RHCE RHD SLC30A6

1.07e-03627829GO:0022890
GeneOntologyMolecularFunctionammonium channel activity

RHCE RHD

1.07e-0312822GO:0008519
GeneOntologyMolecularFunctionacetylcholine binding

CHRNA1 CHRNB2

1.26e-0313822GO:0042166
GeneOntologyMolecularFunctionchannel activity

NALF1 TRPC1 SCN10A KCNT1 CHRNA1 CHRNB2 RHCE RHD

1.40e-03525828GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

NALF1 TRPC1 SCN10A KCNT1 CHRNA1 CHRNB2 RHCE RHD

1.42e-03526828GO:0022803
GeneOntologyMolecularFunctioncytoskeletal motor activity

KIF21B MYH8 MYO1A MYH15

1.42e-03118824GO:0003774
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

CNNM4 NALF1 TRPC1 SCN10A SLC30A9 KCNT1 CHRNA1 CHRNB2 SLC30A6

1.59e-03664829GO:0008324
GeneOntologyMolecularFunctionRNA polymerase II-specific DNA-binding transcription factor binding

PRAMEF19 PRAMEF15 PITX1 PRAMEF4 SLC30A9 PRAMEF27 PRAME

1.63e-03417827GO:0061629
GeneOntologyMolecularFunctionphosphatidylinositol-3,5-bisphosphate phosphatase activity

MTMR3 OCRL

1.93e-0316822GO:0106018
GeneOntologyMolecularFunctionacetylcholine-gated monoatomic cation-selective channel activity

CHRNA1 CHRNB2

2.18e-0317822GO:0022848
GeneOntologyMolecularFunctiontransporter activity

SLC7A9 CNNM4 NALF1 TRPC1 SCN10A SLC30A9 KCNT1 CHRNA1 SLC38A6 CHRNB2 RHCE RHD SLC30A6

2.19e-0312898213GO:0005215
GeneOntologyMolecularFunctionmonoatomic cation channel activity

NALF1 TRPC1 SCN10A KCNT1 CHRNA1 CHRNB2

2.88e-03343826GO:0005261
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

CNNM4 NALF1 TRPC1 SCN10A SLC30A9 KCNT1 SLC30A6

3.00e-03465827GO:0046873
GeneOntologyMolecularFunctionamino acid binding

IDO1 ASS1 NOS2

3.38e-0373823GO:0016597
GeneOntologyMolecularFunctionpostsynaptic neurotransmitter receptor activity

CHRNA1 CHRNB2 HRH3

3.64e-0375823GO:0098960
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

CNNM4 NALF1 TRPC1 SCN10A SLC30A9 KCNT1 RHCE RHD SLC30A6

3.86e-03758829GO:0015318
GeneOntologyBiologicalProcessoocyte development

TDRD5 PRAMEF19 PRAMEF15 PRAMEF4 ZP3

4.69e-0599825GO:0048599
GeneOntologyBiologicalProcessacetylcholine receptor signaling pathway

TRPC1 CHRNA1 CHRNB2 HRH3

5.03e-0551824GO:0095500
GeneOntologyBiologicalProcessoocyte differentiation

TDRD5 PRAMEF19 PRAMEF15 PRAMEF4 ZP3

5.66e-05103825GO:0009994
GeneOntologyBiologicalProcesscellular response to acetylcholine

TRPC1 CHRNA1 CHRNB2 HRH3

5.86e-0553824GO:1905145
GeneOntologyBiologicalProcesspositive regulation of cell population proliferation

PRAMEF25 PRAMEF9 PRAMEF19 TIRAP PRAMEF15 CLEC7A PELI1 S1PR2 PRAMEF4 RPA1 ZP3 PRAMEF27 PRAME CHRNB2 HRH3

6.20e-0511908215GO:0008284
GeneOntologyBiologicalProcessresponse to acetylcholine

TRPC1 CHRNA1 CHRNB2 HRH3

7.28e-0556824GO:1905144
GeneOntologyBiologicalProcesspostsynaptic signal transduction

TRPC1 CHRNA1 CHRNB2 HRH3

1.65e-0469824GO:0098926
GeneOntologyCellularComponentCul2-RING ubiquitin ligase complex

PRAMEF9 PRAMEF19 PRAMEF15 PRAMEF4 PRAMEF27 PRAME

3.07e-0847836GO:0031462
GeneOntologyCellularComponentcullin-RING ubiquitin ligase complex

PRAMEF9 PRAMEF19 PRAMEF15 PRAMEF4 PRAMEF27 PRAME USP47

2.16e-05212837GO:0031461
GeneOntologyCellularComponentubiquitin ligase complex

PRAMEF9 PRAMEF19 PRAMEF15 PRAMEF4 PRAMEF27 PRAME USP47

5.02e-04352837GO:0000151
GeneOntologyCellularComponentankyrin-1 complex

RHCE RHD

6.87e-0410832GO:0170014
HumanPhenoPositive direct antiglobulin test

RHCE RHD

6.36e-053242HP:0032366
HumanPhenoAnti-erythrocyte autoantibody positivity

RHCE RHD

6.36e-053242HP:6000388
MousePhenoabnormal spermatogonia proliferation

PRAMEF19 PRAMEF15 PRAMEF4 PRAMEF27 PRAME

2.85e-0647675MP:0002685
MousePhenoenlarged urinary bladder

MYH8 PRAMEF19 PRAMEF15 HGSNAT ZFYVE26 PRAMEF4

1.89e-05116676MP:0011874
DomainPRAME_family

PRAMEF25 PRAMEF19 PRAMEF15 PRAMEF4 PRAMEF27 PRAME

1.66e-1019836IPR026271
Domain-

CMIP PRAMEF25 PRAMEF19 PRAMEF15 LRRC61 LRTM2 PRAMEF4 PRAMEF27 PRAME

1.26e-053218393.80.10.10
DomainL_dom-like

CMIP PRAMEF25 PRAMEF19 PRAMEF15 LRRC61 LRTM2 PRAMEF4 PRAMEF27 PRAME

1.50e-05328839IPR032675
DomainAmmonium_transpt

RHCE RHD

1.93e-045832IPR001905
DomainAmmonium_transp

RHCE RHD

1.93e-045832PF00909
DomainNH4_transpt_AmtB-like_dom

RHCE RHD

1.93e-045832IPR024041
DomainRhesusRHD

RHCE RHD

1.93e-045832IPR002229
Domain-

RHCE RHD

4.04e-0478321.10.3430.10
DomainAmmonium/urea_transptr

RHCE RHD

4.04e-047832IPR029020
DomainMyosin_head_motor_dom

MYH8 MYO1A MYH15

6.38e-0438833IPR001609
DomainMYOSIN_MOTOR

MYH8 MYO1A MYH15

6.38e-0438833PS51456
DomainMyosin_head

MYH8 MYO1A MYH15

6.38e-0438833PF00063
DomainMYSc

MYH8 MYO1A MYH15

6.38e-0438833SM00242
DomainIQ

MYH8 MYO1A SCN10A MYH15

7.84e-0493834PS50096
DomainCation_efflux

SLC30A9 SLC30A6

8.58e-0410832IPR002524
DomainCation_efflux

SLC30A9 SLC30A6

8.58e-0410832PF01545
Domain-

SLC30A9 SLC30A6

1.05e-03118321.20.1510.10
DomainCation_efflux_TMD

SLC30A9 SLC30A6

1.05e-0311832IPR027469
DomainTUDOR

TDRD5 TDRD15

1.72e-0314832PF00567
DomainMyosin_N

MYH8 MYH15

1.97e-0315832PF02736
DomainMyosin_N

MYH8 MYH15

1.97e-0315832IPR004009
DomainNicotinic_acetylcholine_rcpt

CHRNA1 CHRNB2

2.25e-0316832IPR002394
DomainMyosin_tail_1

MYH8 MYH15

2.85e-0318832PF01576
DomainMyosin_tail

MYH8 MYH15

2.85e-0318832IPR002928
DomainMyosin-like_IQ_dom

MYH8 MYH15

3.18e-0319832IPR027401
Domain-

MYH8 MYH15

3.18e-03198324.10.270.10
DomainIQ

MYH8 MYO1A SCN10A

3.89e-0371833PF00612
Domain-

CHRNA1 CHRNB2

4.65e-03238321.20.120.370
DomainAcetylcholine_rcpt_TM

CHRNA1 CHRNB2

4.65e-0323832IPR027361
DomainTUDOR

TDRD5 TDRD15

4.65e-0323832PS50304
DomainTUDOR

TDRD5 TDRD15

6.37e-0327832SM00333
DomainIPT

MET PKHD1L1

6.37e-0327832SM00429
DomainFYVE

MTMR3 ZFYVE26

7.33e-0329832PF01363
DomainFYVE

MTMR3 ZFYVE26

7.33e-0329832SM00064
DomainIQ_motif_EF-hand-BS

MYH8 MYO1A SCN10A

7.53e-0390833IPR000048
DomainTudor

TDRD5 TDRD15

7.83e-0330832IPR002999
DomainTIG

MET PKHD1L1

8.35e-0331832PF01833
Pubmed

Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice.

PRAMEF19 PRAMEF15 PRAMEF4 PRAMEF27 PRAME

2.49e-092289531729367
Pubmed

MAGE-B4, a binding partner of PRAMEF12, is dispensable for spermatogenesis and male fertility in mice.

PRAMEF19 PRAMEF15 PRAMEF4 PRAMEF27 PRAME

5.00e-092589537451217
Pubmed

Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.

PRAMEF19 PRAMEF15 PRAMEF4 PRAMEF27 PRAME

9.19e-092889525089626
Pubmed

Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse.

PRAMEF19 PRAMEF15 PRAMEF4 PRAMEF27 PRAME

2.99e-083589519389355
Pubmed

Preferentially Expressed Antigen in Melanoma (PRAME) and the PRAME Family of Leucine-Rich Repeat Proteins.

PRAMEF19 PRAMEF15 PRAMEF4 PRAMEF27

1.88e-072089426694250
Pubmed

Organization of the gene (RHCE) encoding the human blood group RhCcEe antigens and characterization of the promoter region.

RHCE RHD

6.48e-0628928188244
Pubmed

E variants found in Japanese and c antigenicity alteration without substitution in the second extracellular loop.

RHCE RHD

6.48e-06289211724987
Pubmed

Tryptophan availability selectively limits NO-synthase induction in macrophages.

IDO1 NOS2

6.48e-06289212525575
Pubmed

DCS-1, DCS-2, and DFV share amino acid substitutions at the extracellular RhD protein vestibule.

RHCE RHD

6.48e-06289217900276
Pubmed

RHD and RHCE molecular analysis in weak D blood donors and in patients with Rh antibodies against their own corresponding Rh antigen.

RHCE RHD

6.48e-06289232697929
Pubmed

The Rh blood group system: a review.

RHCE RHD

6.48e-06289210627438
Pubmed

Polymorphisms in the promoter regions of RHD and RHCE genes in the Chinese Han population.

RHCE RHD

6.48e-06289237823181
Pubmed

Sequence diversity of the Rh blood group system in Basques.

RHCE RHD

6.48e-06289230089826
Pubmed

Review: the molecular basis of the Rh blood group phenotypes.

RHCE RHD

6.48e-06289215373666
Pubmed

Interplay between IDO1 and iNOS in human retinal pigment epithelial cells.

IDO1 NOS2

6.48e-06289231267172
Pubmed

Intron 4 of the RH Gene in Han Chinese, Tibetan, and Mongol Populations.

RHCE RHD

6.48e-06289226579938
Pubmed

Accurate long-read sequencing allows assembly of the duplicated RHD and RHCE genes harboring variants relevant to blood transfusion.

RHCE RHD

6.48e-06289234968422
Pubmed

Transfusion strategy for weak D Type 4.0 based on RHD alleles and RH haplotypes in Tunisia.

RHCE RHD

6.48e-06289229193104
Pubmed

Regarding the size of Rh proteins.

RHCE RHD

6.48e-0628921898705
Pubmed

PCR screening for common weak D types shows different distributions in three Central European populations.

RHCE RHD

6.48e-06289211161244
Pubmed

RH diversity in Mali: characterization of a new haplotype RHD*DIVa/RHCE*ceTI(D2).

RHCE RHD

6.48e-06289225857637
Pubmed

The low-prevalence Rh antigen STEM (RH49) is encoded by two different RHCE*ce818T alleles that are often in cis to RHD*DOL.

RHCE RHD

6.48e-06289222738288
Pubmed

Multiple Rh messenger RNA isoforms are produced by alternative splicing.

RHCE RHD

6.48e-0628921379850
Pubmed

RHCE variants inherited with altered RHD alleles in Brazilian blood donors.

RHCE RHD

6.48e-06289227111588
Pubmed

Characterization of the mouse Rh blood group gene.

RHCE RHD

6.48e-06289210329015
Pubmed

Alteration of RH gene structure and expression in human dCCee and DCW-red blood cells: phenotypic homozygosity versus genotypic heterozygosity.

RHCE RHD

6.48e-0628928822955
Pubmed

Kynurenine is an endothelium-derived relaxing factor produced during inflammation.

IDO1 NOS2

6.48e-06289220190767
Pubmed

Genetic recombination at the human RH locus: a family study of the red-cell Evans phenotype reveals a transfer of exons 2-6 from the RHD to the RHCE gene.

RHCE RHD

6.48e-0628928808597
Pubmed

Molecular background of Rh D-positive, D-negative, D(el) and weak D phenotypes in Chinese.

RHCE RHD

6.48e-06289212201845
Pubmed

Variant RH alleles and Rh immunisation in patients with sickle cell disease.

RHCE RHD

6.48e-06289224960646
Pubmed

RHCE*ceMO is frequently in cis to RHD*DAU0 and encodes a hr(S) -, hr(B) -, RH:-61 phenotype in black persons: clinical significance.

RHCE RHD

6.48e-06289223772606
Pubmed

Comprehensive phenotypic and molecular investigation of RhD and RhCE variants in Moroccan blood donors.

RHCE RHD

6.48e-06289230418133
Pubmed

A convenient qualitative and quantitative method to investigate RHD-RHCE hybrid genes.

RHCE RHD

6.48e-06289223550903
Pubmed

Molecular cloning and primary structure of the human blood group RhD polypeptide.

RHCE RHD

6.48e-0628921438298
Pubmed

Determination of the N-terminal sequence of human red cell Rh(D) polypeptide and demonstration that the Rh(D), (c), and (E) antigens are carried by distinct polypeptide chains.

RHCE RHD

6.48e-0628923135863
Pubmed

Molecular background of D(C)(e) haplotypes within the white population.

RHCE RHD

6.48e-06289212084172
Pubmed

The analysis of nucleotide substitutions, gaps, and recombination events between RHD and RHCE genes through complete sequencing.

RHCE RHD

6.48e-06289210924335
Pubmed

Sequences and evolution of mammalian RH gene transcripts and proteins.

RHCE RHD

6.48e-0628929811965
Pubmed

A two-locus gene conversion model with selection and its application to the human RHCE and RHD genes.

RHCE RHD

6.48e-06289212857961
Pubmed

Specific amino acid substitutions cause distinct expression of JAL (RH48) and JAHK (RH53) antigens in RhCE and not in RhD.

RHCE RHD

6.48e-06289220233350
Pubmed

Rare RHCE phenotypes in black individuals of Afro-Caribbean origin: identification and transfusion safety.

RHCE RHD

6.48e-06289212393640
Pubmed

Molecular genetic basis of the human Rhesus blood group system.

RHCE RHD

6.48e-0628928220426
Pubmed

A recombination hot spot in the Rh genes revealed by analysis of unrelated donors with the rare D-- phenotype.

RHCE RHD

6.48e-0628928900235
Pubmed

RHD*weak partial 4.0 is associated with an altered RHCE*ce(48C, 105T, 733G, 744C, 1025T) allele in the Tunisian population.

RHCE RHD

6.48e-06289223742316
Pubmed

Isolation of a new cDNA clone encoding an Rh polypeptide associated with the Rh blood group system.

RHCE RHD

6.48e-0628927916743
Pubmed

A comprehensive survey of both RHD and RHCE allele frequencies in sub-Saharan Africa.

RHCE RHD

6.48e-06289224033223
Pubmed

RHD*DOL1 and RHD*DOL2 encode a partial D antigen and are in cis with the rare RHCE*ceBI allele in people of African descent.

RHCE RHD

6.48e-06289222690701
Pubmed

No Distinction of Orthology/Paralogy between Human and Chimpanzee Rh Blood Group Genes.

RHCE RHD

6.48e-06289226872772
Pubmed

RHCE*ceTI encodes partial c and partial e and is often in cis to RHD*DIVa.

RHCE RHD

6.48e-06289222804620
Pubmed

Intricate combinatorial patterns of exon splicing generate multiple Rh-related isoforms in human erythroid cells.

RHCE RHD

6.48e-0628927789951
Pubmed

Differential expression of PRAMEL1, a cancer/testis antigen, during spermatogenesis in the mouse.

PRAMEF19 PRAMEF15 PRAMEF4

1.07e-051789323565261
Pubmed

Mouse Pramel1 regulates spermatogonial development by inhibiting retinoic acid signaling during spermatogenesis.

PRAMEF19 PRAMEF15 PRAMEF4

1.07e-051789337781892
Pubmed

The promoter of the oocyte-specific gene, Oog1, functions in both male and female meiotic germ cells in transgenic mice.

PRAMEF19 PRAMEF15 PRAMEF4

1.29e-051889323894331
Pubmed

Oogenesin is a novel mouse protein expressed in oocytes and early cleavage-stage embryos.

PRAMEF19 PRAMEF15 PRAMEF4

1.29e-051889312890732
Pubmed

Oocyte-specific gene Oog1 suppresses the expression of spermatogenesis-specific genes in oocytes.

PRAMEF19 PRAMEF15 PRAMEF4

1.29e-051889329731491
Pubmed

Identification of a new expanding family of genes characterized by atypical LRR domains. Localization of a cluster preferentially expressed in oocyte.

PRAMEF19 PRAMEF15 PRAMEF4

1.29e-051889314675769
Pubmed

Pramel15 facilitates zygotic nuclear DNMT1 degradation and DNA demethylation.

PRAMEF19 PRAMEF15 PRAMEF4

1.29e-051889339181896
Pubmed

Pramel7 mediates ground-state pluripotency through proteasomal-epigenetic combined pathways.

PRAMEF19 PRAMEF15 PRAMEF4

1.52e-051989328604677
Pubmed

ZAR1 and ZAR2 are required for oocyte meiotic maturation by regulating the maternal transcriptome and mRNA translational activation.

PRAMEF19 PRAMEF15 PRAMEF4 CPEB1

1.53e-055889431598710
Pubmed

Oog1, an oocyte-specific protein, interacts with Ras and Ras-signaling proteins during early embryogenesis.

PRAMEF19 PRAMEF15 PRAMEF4

1.79e-052089316580637
Pubmed

Pramel7 mediates LIF/STAT3-dependent self-renewal in embryonic stem cells.

PRAMEF19 PRAMEF15 PRAMEF4

1.79e-052089321425410
Pubmed

Reactive Neutrophil Responses Dependent on the Receptor Tyrosine Kinase c-MET Limit Cancer Immunotherapy.

MET NOS2

1.94e-05389229045907
Pubmed

Therapeutic targeting of argininosuccinate synthase 1 (ASS1)-deficient pulmonary fibrosis.

MET ASS1

1.94e-05389233508432
Pubmed

Generation and characterisation of Rhd and Rhag null mice.

RHCE RHD

1.94e-05389219807729
Pubmed

Identification of four classes of brain nicotinic receptors using beta2 mutant mice.

CHRNA1 CHRNB2

1.94e-0538929614223
Pubmed

Hydrophobic cluster analysis and modeling of the human Rh protein three-dimensional structures.

RHCE RHD

1.94e-05389216584906
Pubmed

Evolutionary history of the Rh blood group-related genes in vertebrates.

RHCE RHD

1.94e-05389210970100
Pubmed

Promotion of Anti-Tuberculosis Macrophage Activity by L-Arginine in the Absence of Nitric Oxide.

ASS1 NOS2

1.94e-05389234054815
Pubmed

Conserved evolution of the Rh50 gene compared to its homologous Rh blood group gene.

RHCE RHD

1.94e-0538929705835
Pubmed

The expansion of the PRAME gene family in Eutheria.

PRAMEF19 PRAME

1.94e-05389221347312
Pubmed

Binding of HIV-1 gp120 to the nicotinic receptor.

CHRNA1 CHRNB2

1.94e-0538921397297
Pubmed

The members of the RH gene family (RH50 and RH30) followed different evolutionary pathways.

RHCE RHD

1.94e-0538929929383
Pubmed

Protein-sequence studies on Rh-related polypeptides suggest the presence of at least two groups of proteins which associate in the human red-cell membrane.

RHCE RHD

1.94e-0538923146980
Pubmed

Oogenesis specific genes (Nobox, Oct4, Bmp15, Gdf9, Oogenesin1 and Oogenesin2) are differentially expressed during natural and gonadotropin-induced mouse follicular development.

PRAMEF19 PRAMEF15 PRAMEF4

2.76e-052389319480014
Pubmed

Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei.

PRAMEF19 PRAMEF15 PRAMEF4

3.58e-052589312620990
Pubmed

Entire sequence of a mouse chromosomal segment containing the gene Rhced and a comparative analysis of the homologous human sequence.

RHCE RHD

3.87e-05489212459264
Pubmed

HLA-DRB1 molecules and the presentation of anchor peptides from RhD, RhCE, and KEL proteins.

RHCE RHD

3.87e-05489233675036
Pubmed

Association between ABO, Rhesus blood group systems and haemoglobin genotype among confirmed HIV/AIDS-TB co-infected patients in Enugu Urban, Nigeria.

RHCE RHD

3.87e-05489216722361
Pubmed

Expression profiling in transgenic FVB/N embryonic stem cells overexpressing STAT3.

PRAMEF19 PRAMEF15 PRAMEF4

4.04e-052689318500982
Pubmed

Thirteen Ovary-Enriched Genes Are Individually Not Essential for Female Fertility in Mice.

PRAMEF19 PRAMEF15 PRAMEF4

6.26e-053089338786026
Pubmed

RHCE represents the ancestral RH position, while RHD is the duplicated gene.

RHCE RHD

6.44e-05589211902138
Pubmed

Evolutionary conservation and diversification of Rh family genes and proteins.

RHCE RHD

6.44e-05589216227429
Pubmed

Genetic variation of innate immune genes in HIV-infected african patients with or without oropharyngeal candidiasis.

TIRAP CLEC7A

6.44e-05589220577092
Pubmed

LSM14B is essential for oocyte meiotic maturation by regulating maternal mRNA storage and clearance.

PRAMEF19 PRAMEF15 PRAMEF4

7.61e-053289337889087
Pubmed

Intralesional expression of mRNA of interferon- gamma , tumor necrosis factor- alpha , interleukin-10, nitric oxide synthase, indoleamine-2,3-dioxygenase, and RANTES is a major immune effector in Mediterranean spotted fever rickettsiosis.

IDO1 NOS2

9.65e-05689217674321
Pubmed

Conservation of dishevelled structure and function between flies and mice: isolation and characterization of Dvl2.

DVL2 NOS2

9.65e-0568928887313
Pubmed

SELENOPROTEINS. CRL2 aids elimination of truncated selenoproteins produced by failed UGA/Sec decoding.

PRAMEF9 PRAME

1.35e-04789226138980
Pubmed

Distinct roles for Dectin-1 and TLR4 in the pathogenesis of Aspergillus fumigatus keratitis.

TIRAP CLEC7A

1.79e-04889220617171
Pubmed

Mbd3, a component of the NuRD co-repressor complex, is required for development of pluripotent cells.

PRAMEF19 PRAMEF15 PRAMEF4

2.27e-044689317287250
Pubmed

Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci.

MALRD1 PSMG1

2.30e-04989220062062
Pubmed

Nociceptors Boost the Resolution of Fungal Osteoinflammation via the TRP Channel-CGRP-Jdp2 Axis.

SCN10A CLEC7A

2.30e-04989228658621
Pubmed

Intracellular zinc homeostasis in leukocyte subsets is regulated by different expression of zinc exporters ZnT-1 to ZnT-9.

SLC30A9 SLC30A6

2.30e-04989217971500
Pubmed

Autosomal Dominant Sleep-Related Hypermotor (Hyperkinetic) Epilepsy

KCNT1 CHRNB2

2.88e-041089220301348
Pubmed

Zinc transporter 2 (SLC30A2) can suppress the vesicular zinc defect of adaptor protein 3-depleted fibroblasts by promoting zinc accumulation in lysosomes.

SLC30A9 SLC30A6

2.88e-041089217349999
Pubmed

DUX is a non-essential synchronizer of zygotic genome activation.

PRAMEF19 PRAMEF15 PRAMEF4

2.91e-045089331806660
Pubmed

[Genetic predisposition to development of toxic liver cirrhosis caused by alcohol].

RHCE RHD

3.51e-041189211436564
Pubmed

A multiprotein nuclear complex connects Fanconi anemia and Bloom syndrome.

FANCG RPA1

4.20e-041289212724401
Pubmed

A novel ubiquitin ligase is deficient in Fanconi anemia.

FANCG RPA1

4.20e-041289212973351
Pubmed

The mouse Rhl1 and Rhag genes: sequence, organization, expression, and chromosomal mapping.

RHCE RHD

4.20e-041289210495887
Pubmed

Homologs of genes expressed in Caenorhabditis elegans GABAergic neurons are also found in the developing mouse forebrain.

MYH8 PITX1 FOXI2

4.29e-045789321122108
Cytoband1p36.21

PRAMEF25 PRAMEF9 PRAMEF19 PRAMEF15 PRAMEF4

1.66e-07639051p36.21
CytobandEnsembl 112 genes in cytogenetic band chr1p36

PRAMEF25 PRAMEF9 PRAMEF19 PRAMEF15 PRAMEF4 PRAMEF27 RHCE RHD

5.99e-05681908chr1p36
Cytoband22q11.22

RAB36 PRAME

9.36e-042390222q11.22
GeneFamilyPRAME family

PRAMEF25 PRAMEF9 PRAMEF19 PRAMEF15 PRAMEF4 PRAMEF27 PRAME

1.30e-1224627686
GeneFamilyMyosin heavy chains

MYH8 MYH15

1.18e-03156221098
GeneFamilyCholinergic receptors nicotinic subunits

CHRNA1 CHRNB2

1.35e-0316622173
GeneFamilyZinc fingers FYVE-type|Pleckstrin homology domain containing|Rho guanine nucleotide exchange factors

MTMR3 ZFYVE26

5.05e-033162281
GeneFamilyPhosphoinositide phosphatases

MTMR3 OCRL

5.37e-03326221079
GeneFamilyGlycosyltransferase family 6|Blood group antigens

RHCE RHD

7.13e-0337622454
GeneFamilyTudor domain containing

TDRD5 TDRD15

7.13e-0337622780
CoexpressionGSE46242_TH1_VS_ANERGIC_TH1_CD4_TCELL_WITH_EGR2_DELETED_UP

CNNM4 GANC IDO1 UGGT2 S1PR2 RMC1 CPEB1

4.58e-06199877M9716
CoexpressionKOHOUTEK_CCNT2_TARGETS

PRAMEF19 PRAMEF15 PRAMEF4 PRAMEF27 PRAME

7.54e-0681875MM938
CoexpressionBYSTRYKH_HEMATOPOIESIS_STEM_CELL_AND_BRAIN_QTL_TRANS

PRAMEF19 PRAMEF15 PRAMEF4 RMC1 PCK2 ZMYM4

3.07e-05180876MM612
ToppCellfacs-Marrow-B-cells-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IDO1 PLA2G4F CTSE PKHD1L1 CHRNB2 RHD

1.19e-0616890617fb9426eeea407b26fb895b8397faca95b7552d
ToppCellfacs-Marrow-B-cells-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IDO1 PLA2G4F CTSE PKHD1L1 CHRNB2 RHD

1.19e-06168906a61b39884851384cffd430079040546d125b2b40
ToppCellCOVID-19-Heart-EC_2|Heart / Disease (COVID-19 only), tissue and cell type

MET CFAP54 CMIP NALF1 MMRN2 PELI1

2.22e-0618790640ffc06a3e3251d9b12da390210d3e045af7537a
ToppCell390C-Myeloid-Macrophage-SPP1+_Macrophage|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

FANCG PDE7A GANC PITX1 ZFYVE26

2.33e-051689058459d0a1bf6d4b5c83001097331f8b78fceb9305
ToppCellEndothelial-B-IPF_04|World / lung cells shred on cell class, cell subclass, sample id

NALF1 TRPC1 MMRN2 PKHD1L1 FAM87A

2.60e-05172905d4e98ff9c7cbc95457e1d71fa60f151a2f178dae
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_monocytic-classical_monocyte-Classical_monocytes-Classical_monocytes_L.1.2.4.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KIF21B CD22 MTMR3 CLEC7A RHCE

2.75e-05174905b6e3fa995def40a8fbdfc249fe108c303931a171
ToppCellTCGA-Bone_and_Soft_Tissue-Primary_Tumor-Sarcoma-Monophasic_Synovial_Sarcoma-5|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9

PRAMEF9 PRAMEF15 PRAMEF4 HRH3

3.82e-05939043e05ea0f8f4a7cdb78a596f47d563dc3c94d4d8e
ToppCellPCW_05-06-Hematologic_ErythroMegGranulo-Hem_ErythroMeg|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

PITX1 CTSE PKHD1L1 RHCE RHD

3.98e-051889055d6faf45a9c0794b0c30b0a0601c10afbb8aa9ed
ToppCellPCW_05-06-Hematologic_ErythroMegGranulo|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

PITX1 CTSE PKHD1L1 RHCE RHD

3.98e-05188905a0873783f0a2cd852563c05a275dddc72905ced2
ToppCellPCW_05-06-Hematologic_ErythroMegGranulo-Hem_ErythroMeg-erythro|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

PITX1 CTSE PKHD1L1 RHCE RHD

3.98e-0518890529d804232d974a8c0029300345b287005b09bade
ToppCellControl-Endothelial-VE_Venous|Endothelial / Disease state, Lineage and Cell class

MET CMIP NALF1 ASS1 MMRN2

4.19e-051909054e30155203b4a8c5e496fcbe9348b67b98ebc625
ToppCellPBMC-Severe-Myeloid-Neutrophil-Neutrophil-Neu_4|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

CNNM4 UGGT2 OCRL USP47 SLC30A6

4.19e-051909053f0c7d130f66faea778fe567604edf1b4cdf85b3
ToppCellPBMC-Severe-Myeloid-Neutrophil-Neutrophil-Neu_4|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CNNM4 UGGT2 OCRL USP47 SLC30A6

4.40e-05192905c09dcc73ff9c3855a0f3d7bfa0d5c99c09a117f2
ToppCellnormal_Lung-Epithelial_cells-Club|normal_Lung / Location, Cell class and cell subclass

MET SUSD4 KRTAP3-1 ASS1 CTSE

4.74e-05195905b46544ad5af04f4dbc2643637caa3d2d50d922ae
ToppCell5'-Adult-SmallIntestine-Epithelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SLC7A9 MALRD1 MYO1A CTSE PCK2

5.09e-051989058d629492d2199de8e036c19e9dacceb9c9e721a0
ToppCell5'-Adult-SmallIntestine-Epithelial-mature_enterocytic-Enterocyte|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SLC7A9 MALRD1 MYO1A CTSE PCK2

5.09e-051989056e6af8fad09f8e48b3f2ce463d5773b6a69864d1
ToppCell5'-Adult-SmallIntestine|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SLC7A9 MALRD1 MYO1A CTSE PCK2

5.22e-05199905a5fffe381be1ba7d192b68d1d3937ce47663658e
ToppCellLung_Parenchyma-Control-Epithelial-Epithelial-Club|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

MET SUSD4 KRTAP3-1 ASS1 CTSE

5.22e-051999052b17694cffbec28a2c8f165dfcff6bab94aa0f4c
ToppCellParenchyma_Control_(B.)-Epithelial-TX-Club|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type

MET SUSD4 KRTAP3-1 ASS1 CTSE

5.22e-05199905111cfd589ec6795075d8d88d7664bfb23eba5bf6
ToppCellLung_Parenchyma-Control-Epithelial-Epithelial-Club-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

MET SUSD4 KRTAP3-1 ASS1 CTSE

5.22e-05199905d583290a1d288b749ad17bc501c1487268c6551c
ToppCell5'-Adult-SmallIntestine-Epithelial-mature_enterocytic|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SLC7A9 MALRD1 MYO1A CTSE PCK2

5.22e-0519990501c2721bc82cd672e9477029b4a7ecc77e2f1b00
ToppCell(53)_Lymphoid_DC|World / shred on Cell_type and subtype

CD300LD-AS1 IDO1 MMRN2 PRAME NSUN7

6.43e-0520890530212cfacad94a7cc562a69efa73a31259851515
DiseaseAnemia, Hemolytic, Congenital

RHCE RHD

7.44e-062812C0002881
DiseaseRh Deficiency Syndrome

RHCE RHD

2.23e-053812C0272052
DiseaseRh-Null, Regulator Type

RHCE RHD

2.23e-053812C1849387
DiseaseFrontal Epilepsy, Benign, Childhood

KCNT1 CHRNB2

4.45e-054812C0393671
DiseaseEpilepsy, Cingulate

KCNT1 CHRNB2

4.45e-054812C0393684
DiseaseEpilepsy, Supplementary Motor

KCNT1 CHRNB2

4.45e-054812C0393683
DiseaseEpilepsy, Opercular

KCNT1 CHRNB2

4.45e-054812C0393688
DiseaseEpilepsy, Orbito-Frontal

KCNT1 CHRNB2

4.45e-054812C0751643
DiseaseEpilepsy, Anterior Fronto-Polar

KCNT1 CHRNB2

4.45e-054812C0751642
DiseaseEpilepsy, Frontal Lobe

KCNT1 CHRNB2

4.45e-054812C0085541
DiseaseAutosomal dominant nocturnal frontal lobe epilepsy

KCNT1 CHRNB2

4.45e-054812cv:C3696898
Diseaseunipolar depression, bipolar disorder

CNNM4 MMRN2 MYH15 TMPRSS5 SLC30A9

7.18e-05156815EFO_0003761, MONDO_0004985
DiseaseAutosomal Dominant Nocturnal Frontal Lobe Epilepsy

KCNT1 CHRNB2

1.55e-047812C3696898
Diseaseautosomal dominant hyaline body myopathy (implicated_via_orthology)

MYH8 MYH15

3.30e-0410812DOID:0111269 (implicated_via_orthology)
Diseasedistal arthrogryposis type 2B3 (implicated_via_orthology)

MYH8 MYH15

3.30e-0410812DOID:0111602 (implicated_via_orthology)
Diseasedistal arthrogryposis type 1 (implicated_via_orthology)

MYH8 MYH15

3.30e-0410812DOID:0111596 (implicated_via_orthology)
Diseasedilated cardiomyopathy 1S (implicated_via_orthology)

MYH8 MYH15

3.30e-0410812DOID:0110454 (implicated_via_orthology)
Diseasecongenital myopathy 6 (implicated_via_orthology)

MYH8 MYH15

3.30e-0410812DOID:0080719 (implicated_via_orthology)
Diseaseinclusion body myositis (implicated_via_orthology)

MYH8 MYH15

3.30e-0410812DOID:3429 (implicated_via_orthology)
Diseasedistal arthrogryposis type 2A (implicated_via_orthology)

MYH8 MYH15

3.30e-0410812DOID:0111605 (implicated_via_orthology)
Diseasefamilial hypertrophic cardiomyopathy (implicated_via_orthology)

MYH8 MYH15

3.30e-0410812DOID:0080326 (implicated_via_orthology)
Diseasedistal myopathy (implicated_via_orthology)

MYH8 MYH15

4.83e-0412812DOID:11720 (implicated_via_orthology)
Diseasemyotonia congenita (implicated_via_orthology)

MYH8 MYH15

4.83e-0412812DOID:2106 (implicated_via_orthology)
Diseaserestrictive cardiomyopathy (implicated_via_orthology)

MYH8 MYH15

5.69e-0413812DOID:397 (implicated_via_orthology)
DiseaseHypothermia, natural

NOS2 CHRNB2

6.63e-0414812C0020672
Diseasedistal arthrogryposis (implicated_via_orthology)

MYH8 MYH15

7.64e-0415812DOID:0050646 (implicated_via_orthology)
DiseaseMalaria, susceptibility to

TIRAP NOS2

8.71e-0416812cv:C1970028
Diseasecongenital myasthenic syndrome (implicated_via_orthology)

CHRNA1 CHRNB2

8.71e-0416812DOID:3635 (implicated_via_orthology)
Disease

TIRAP NOS2

8.71e-0416812611162
DiseaseMalaria

TIRAP NOS2

1.37e-0320812C0024530
Diseasesciatic neuropathy (implicated_via_orthology)

SCN10A HRH3

1.81e-0323812DOID:11446 (implicated_via_orthology)
Diseasemalaria (is_implicated_in)

TIRAP NOS2

1.98e-0324812DOID:12365 (is_implicated_in)
Diseaseankylosing spondylitis

KIF21B MALRD1 NOS2

2.03e-0391813EFO_0003898
Diseaseprimary biliary cholangitis (biomarker_via_orthology)

NOS2 CPEB1

2.69e-0328812DOID:12236 (biomarker_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
YTKLPAQAIPCSLAW

TDRD5

581

Q8NAT2
APCIYWLPLTDSQIV

ACIN1

1221

Q9UKV3
ASNKELCFQWYIPPL

CFAP54

2926

Q96N23
SWENAPKYCLQLTIP

CMIP

121

Q8IY22
PLSFQCLKAPATLTW

CD300LD-AS1

26

Q96MU5
VAKCWDPSPQAYFTL

DVL2

351

O14641
SCYSLAPQIKVIAPW

ASS1

131

P00966
KALYLAGPNCLSPWK

NBEAL1

801

Q6ZS30
SFPKWYTPEACLQLR

RAB36

86

O95755
NANLLAWTCLPLFPK

PIK3C2G

571

O75747
ITWTPPAIFKSYCEI

CHRNA1

136

P02708
SYWVSDKRLPPCSLS

NOS2

811

P35228
PPILVYADCVLANWK

IDO1

121

P14902
YPLLKADPSLWCVSA

MGAT1

226

P26572
LSNPLCANPSYWAAV

LRRC61

136

Q9BV99
LDKTWPAAPYKCLST

MYO1A

801

Q9UBC5
NWCPYPMSKLVTLLA

MMRN2

56

Q9H8L6
VNKCWFLSYIKPSEP

SPINK8

46

P0C7L1
AWAVKDFAPNCPLYV

KCNT1

456

Q5JUK3
NLWVPSVYCTSPACK

CTSE

101

P14091
LWVNAPALSPKSYAS

FOXI2

41

Q6ZQN5
WCYSATLLLAPLPAS

LINC02901

186

Q4VX62
SGLFCVTVNPYKWLP

MYH8

121

P13535
LPKYNNCWLARTDPK

PCK2

86

Q16822
CKPDTYVPTCWLLNN

KRTAP3-1

56

Q9BYR8
PKLPIWLCNINGNYS

MINDY4B

361

A8MYZ0
CYLKEPKLANSVTPW

PDE7A

226

Q13946
DCRVKLWNYVPGLTP

KIF21B

1606

O75037
CWPGLSSYLDFTNPK

GANC

471

Q8TET4
CKWVLPILTQFTPYL

PRAMEF15

216

P0DUQ1
GTKELPYCPLWVSAT

FANCG

441

O15287
LLSKADCYVQLWLPT

PLA2G4F

61

Q68DD2
KSAFKLTWTAQPPCL

RBM12B-AS1

56

Q9P1G2
SGLPCWPYLTAEALK

NPIPB15

226

A6NHN6
PAAVLSYCQVWKIPA

PSMG1

216

O95456
SFEKRSLCKWYQPIP

MALRD1

1091

Q5VYJ5
PIASLTPYQSKWTIC

RPA1

186

P27694
SYPGCQPLKDTRAWA

ATP11AUN

16

Q6ZP68
LAPIISKPTWEYLYC

SLC7A9

426

P82251
IRSPYIDGCSPIKNW

BORA

316

Q6PGQ7
LWANSAVNPVLYPLC

HRH3

401

Q9Y5N1
IVNPNYCLGPLSWDK

HGSNAT

356

Q68CP4
ATCTWSGQLPPRNYK

CPEB1

291

Q9BZB8
ILFIWYCTCKSLPSP

CLDN12

191

P56749
WLPAFSILLLDYACP

S1PR2

246

O95136
AVAPAKFCLWYVVPS

FAM87A

46

P0C7U9
CSWASPVALNVQYAP

CD22

491

P20273
KLCGSYPQELIVPAW

MTMR3

186

Q13615
VRNLMLWSAVYLPCP

MTMR3

566

Q13615
CSEKTTAYWSQIPLP

PELI1

371

Q96FA3
WTQQICLPAIYKVFP

MET

556

P08581
YNNWAAKSLAPAPLS

PITX1

181

P78337
TCTWKLPTLAKFSPY

PRAME

241

P78395
LSPSKFYCQLIKWTP

TDRD15

251

B5MCY1
CWIALYAVEALPTCP

LRTM2

26

Q8N967
SGLFCVTINPYKWLP

MYH15

136

Q9Y2K3
KCLPWYPSLSQLKQL

PRAMEF19

311

Q5SWL8
TLPLYAWINTCKISP

NSUN7

201

Q8NE18
YCRWVAPKALVPTCL

NSUN7

676

Q8NE18
CKWVLPILTQFTPYL

PRAMEF25

216

A6NGN4
IKKWSIPCPLTLNYV

SLC38A6

211

Q8IZM9
SYSSKPPLWAAELCV

SELENOO

651

Q9BVL4
CKWVLPILTQFTPYL

PRAMEF27

216

A3QJZ7
SAAPKLPYDLWFKRC

TBC1D7

196

Q9P0N9
FIPKLNDSQYCKPWL

OCRL

601

Q01968
GSIFWLPPAIYKSAC

CHRNB2

141

P17787
LSSPCPPNWIIYEKS

CLEC7A

116

Q9BXN2
KLYALCTRAQPDGPW

CNNM4

146

Q6P4Q7
WPVLSLCYLIAPKSQ

TRPC1

361

P48995
CKWVLPILTQFTPYL

PRAMEF4

216

O60810
AAYFGLSVAWCLPKP

RHD

176

Q02161
AAYFGLTVAWCLPKP

RHCE

176

P18577
VPCKLYSSSWIVFQP

RMC1

331

Q96DM3
LLPTLWFCSPSAKYF

AGPAT1

21

Q99943
CPPCLTSLSQKYLIW

SCN10A

631

Q9Y5Y9
CKWVLPILTQFTPYL

PRAMEF9

216

P0DUQ2
YLECLQNLIWSSSPP

SUSD4

221

Q5VX71
PKVSTLNVWPLYICD

USP47

1296

Q96K76
WLLVLYLCPAASQPI

TMPRSS5

66

Q9H3S3
KNGYPWVLENPSCSL

TTC41P

146

Q6P2S7
PTKNPFTWLFLLVSC

TECR

231

Q9NZ01
FYINSLTGCKSWKPP

ARHGAP9

231

Q9BRR9
NLPWANKVTIGSYPC

PKHD1L1

1591

Q86WI1
LITPGFLQDPWCKYQ

TIRAP

146

P58753
TCLISYWVTLRKPSP

SLC30A6

76

Q6NXT4
CQVSGAYPPAKILWL

VSIG10

331

Q8N0Z9
PQPIESLLWAYCILA

SLC30A9

336

Q6PML9
YITWPTSCQKLLKPV

UGGT2

456

Q9NYU1
LLLWGSTELCYPQPL

ZP3

11

P21754
STELCYPQPLWLLQG

ZP3

16

P21754
YQKILGLQSPPVWCD

ZFYVE26

1521

Q68DK2
WECKQLGAYSPIVLL

ZMYM4

1366

Q5VZL5
SAKPVWRLETCYPQG

NALF1

161

B1AL88