Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	TSPAN12 OR4A8 OR2T4 OR4C11 OR4C16 OR6Y1 OR4A16 OR4C12 OR2M5 OR9Q2 OR2M3 CHRND OPRK1 OPRM1 TLR6 MTNR1A	6.78e-16	1353	20	16	GO:0004888
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR4A8 OR2T4 OR4C11 OR4C16 OR6Y1 OR4A16 OR4C12 OR2M5 OR9Q2 OR2M3 OPRK1 OPRM1 MTNR1A	1.34e-13	884	20	13	GO:0004930
GeneOntologyMolecularFunction	olfactory receptor activity	OR4A8 OR2T4 OR4C11 OR4C16 OR6Y1 OR4A16 OR4C12 OR2M5 OR9Q2 OR2M3	3.01e-12	431	20	10	GO:0004984
GeneOntologyMolecularFunction	G protein-coupled opioid receptor activity	OPRK1 OPRM1	2.00e-05	7	20	2	GO:0004985
GeneOntologyMolecularFunction	calcium channel activity	ORAI3 OPRM1 PSEN1	2.77e-04	129	20	3	GO:0005262
GeneOntologyMolecularFunction	monoatomic cation channel activity	ORAI3 CHRND OPRM1 PSEN1	3.33e-04	343	20	4	GO:0005261
GeneOntologyMolecularFunction	calcium ion transmembrane transporter activity	ORAI3 OPRM1 PSEN1	4.40e-04	151	20	3	GO:0015085
GeneOntologyMolecularFunction	neuropeptide binding	OPRK1 OPRM1	6.22e-04	37	20	2	GO:0042923
GeneOntologyMolecularFunction	monoatomic ion channel activity	ORAI3 CHRND OPRM1 PSEN1	9.97e-04	459	20	4	GO:0005216
GeneOntologyMolecularFunction	channel activity	ORAI3 CHRND OPRM1 PSEN1	1.64e-03	525	20	4	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	ORAI3 CHRND OPRM1 PSEN1	1.65e-03	526	20	4	GO:0022803
GeneOntologyMolecularFunction	peptide binding	OPRK1 OPRM1 TLR6	3.73e-03	318	20	3	GO:0042277
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	ORAI3 CHRND OPRM1 PSEN1	3.84e-03	664	20	4	GO:0008324
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	ORAI3 CHRND OPRM1 PSEN1	7.19e-03	793	20	4	GO:0015075
GeneOntologyMolecularFunction	G protein-coupled peptide receptor activity	OPRK1 OPRM1	7.73e-03	133	20	2	GO:0008528
GeneOntologyMolecularFunction	peptide receptor activity	OPRK1 OPRM1	8.54e-03	140	20	2	GO:0001653
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	ORAI3 OPRM1 PSEN1	1.07e-02	465	20	3	GO:0046873
GeneOntologyMolecularFunction	growth factor receptor binding	IL21 PSEN1	1.28e-02	173	20	2	GO:0070851
GeneOntologyBiologicalProcess	detection of chemical stimulus	OR4A8 OR2T4 OR4C11 OR4C16 OR6Y1 OR4A16 OR4C12 OR2M5 OR9Q2 OR2M3 TLR6	3.50e-13	524	20	11	GO:0009593
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of smell	OR4A8 OR2T4 OR4C11 OR4C16 OR6Y1 OR4A16 OR4C12 OR2M5 OR9Q2 OR2M3	2.24e-12	432	20	10	GO:0050911
GeneOntologyBiologicalProcess	sensory perception of smell	OR4A8 OR2T4 OR4C11 OR4C16 OR6Y1 OR4A16 OR4C12 OR2M5 OR9Q2 OR2M3	4.65e-12	465	20	10	GO:0007608
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception	OR4A8 OR2T4 OR4C11 OR4C16 OR6Y1 OR4A16 OR4C12 OR2M5 OR9Q2 OR2M3	7.05e-12	485	20	10	GO:0050907
GeneOntologyBiologicalProcess	detection of stimulus	OR4A8 OR2T4 OR4C11 OR4C16 OR6Y1 OR4A16 OR4C12 OR2M5 OR9Q2 OR2M3 TLR6	1.13e-11	722	20	11	GO:0051606
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	OR4A8 OR2T4 OR4C11 OR4C16 OR6Y1 OR4A16 OR4C12 OR2M5 OR9Q2 OR2M3	2.31e-11	547	20	10	GO:0007606
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	OR4A8 OR2T4 OR4C11 OR4C16 OR6Y1 OR4A16 OR4C12 OR2M5 OR9Q2 OR2M3 OPRK1 OPRM1 MTNR1A	2.91e-11	1395	20	13	GO:0007186
GeneOntologyBiologicalProcess	sensory perception	OR4A8 OR2T4 OR4C11 OR4C16 OR6Y1 OR4A16 OR4C12 OR2M5 OR9Q2 OR2M3 OPRK1 OPRM1	3.13e-11	1072	20	12	GO:0007600
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	OR4A8 OR2T4 OR4C11 OR4C16 OR6Y1 OR4A16 OR4C12 OR2M5 OR9Q2 OR2M3	4.25e-11	582	20	10	GO:0050906
GeneOntologyBiologicalProcess	adenylate cyclase-inhibiting opioid receptor signaling pathway	OPRK1 OPRM1	2.68e-06	3	20	2	GO:0031635
GeneOntologyBiologicalProcess	negative regulation of luteinizing hormone secretion	OPRK1 OPRM1	1.34e-05	6	20	2	GO:0033685
GeneOntologyBiologicalProcess	regulation of luteinizing hormone secretion	OPRK1 OPRM1	4.00e-05	10	20	2	GO:0033684
GeneOntologyBiologicalProcess	reproductive behavior	OPRK1 OPRM1 MTNR1A	4.84e-05	74	20	3	GO:0019098
GeneOntologyBiologicalProcess	negative regulation of gonadotropin secretion	OPRK1 OPRM1	4.89e-05	11	20	2	GO:0032277
GeneOntologyBiologicalProcess	G protein-coupled opioid receptor signaling pathway	OPRK1 OPRM1	6.92e-05	13	20	2	GO:0038003
GeneOntologyBiologicalProcess	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	OPRK1 OPRM1 MTNR1A	7.58e-05	86	20	3	GO:0007193
GeneOntologyBiologicalProcess	luteinizing hormone secretion	OPRK1 OPRM1	8.07e-05	14	20	2	GO:0032275
GeneOntologyBiologicalProcess	regulation of gonadotropin secretion	OPRK1 OPRM1	1.06e-04	16	20	2	GO:0032276
GeneOntologyBiologicalProcess	negative regulation of hormone secretion	OPRK1 OPRM1 MTNR1A	1.30e-04	103	20	3	GO:0046888
GeneOntologyBiologicalProcess	gonadotropin secretion	OPRK1 OPRM1	2.04e-04	22	20	2	GO:0032274
MousePheno	impaired behavioral response to anesthetic	OPRK1 OPRM1	4.60e-06	5	10	2	MP:0009778
MousePheno	impaired behavioral response to morphine	OPRK1 OPRM1	2.07e-05	10	10	2	MP:0009757
MousePheno	abnormal behavioral response to anesthetic	OPRK1 OPRM1	3.03e-05	12	10	2	MP:0009777
MousePheno	abnormal behavioral response to morphine	OPRK1 OPRM1	3.58e-05	13	10	2	MP:0020159
MousePheno	decreased chemically-elicited antinociception	OPRK1 OPRM1	7.83e-05	19	10	2	MP:0001982
MousePheno	abnormal chemically-elicited antinociception	OPRK1 OPRM1	1.85e-04	29	10	2	MP:0001980
MousePheno	impaired behavioral response to addictive substance	OPRK1 OPRM1	4.49e-04	45	10	2	MP:0009750
Domain	GPCR_Rhodpsn_7TM	OR2T4 OR4C11 OR4C16 OR6Y1 OR4A16 OR4C12 OR2M5 OR9Q2 OR2M3 OPRK1 OPRM1 MTNR1A	1.65e-13	670	19	12	IPR017452
Domain	7tm_1	OR2T4 OR4C11 OR4C16 OR6Y1 OR4A16 OR4C12 OR2M5 OR9Q2 OR2M3 OPRK1 OPRM1 MTNR1A	1.87e-13	677	19	12	PF00001
Domain	G_PROTEIN_RECEP_F1_1	OR2T4 OR4C11 OR4C16 OR6Y1 OR4A16 OR4C12 OR2M5 OR9Q2 OR2M3 OPRK1 OPRM1 MTNR1A	2.15e-13	685	19	12	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR2T4 OR4C11 OR4C16 OR6Y1 OR4A16 OR4C12 OR2M5 OR9Q2 OR2M3 OPRK1 OPRM1 MTNR1A	2.38e-13	691	19	12	PS50262
Domain	GPCR_Rhodpsn	OR2T4 OR4C11 OR4C16 OR6Y1 OR4A16 OR4C12 OR2M5 OR9Q2 OR2M3 OPRK1 OPRM1 MTNR1A	2.42e-13	692	19	12	IPR000276
Domain	Olfact_rcpt	OR2T4 OR4C11 OR4C16 OR6Y1 OR4A16 OR4C12 OR2M5 OR9Q2 OR2M3	5.66e-11	393	19	9	IPR000725
Domain	Opioid_rcpt	OPRK1 OPRM1	5.88e-06	4	19	2	IPR001418
Domain	7TM_GPCR_Srsx	OR2M3 OPRK1 MTNR1A	1.90e-04	112	19	3	SM01381
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR4A8 OR2T4 OR4C11 OR4C16 OR6Y1 OR4A16 OR4C12 OR2M5 OR9Q2 OR2M3	3.36e-11	417	19	10	M4072
Pathway	KEGG_OLFACTORY_TRANSDUCTION	OR2T4 OR4C11 OR4C16 OR6Y1 OR4A16 OR4C12 OR2M5 OR9Q2 OR2M3	6.12e-10	389	19	9	M14091
Pathway	REACTOME_SENSORY_PERCEPTION	OR4A8 OR2T4 OR4C11 OR4C16 OR6Y1 OR4A16 OR4C12 OR2M5 OR9Q2 OR2M3	2.08e-09	636	19	10	M41834
Pathway	REACTOME_MECP2_REGULATES_NEURONAL_RECEPTORS_AND_CHANNELS	OPRK1 OPRM1	2.60e-04	18	19	2	M27901
Pathway	KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	CHRND OPRK1 OPRM1 MTNR1A	4.18e-04	272	19	4	M13380
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR4A8 OR2T4 OR4C11 OR4C16 OR6Y1 OR4A16 OR4C12 OR2M5 OR9Q2 OR2M3	1.18e-15	340	20	10	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR4A8 OR2T4 OR4C11 OR4C16 OR6Y1 OR4A16 OR4C12 OR2M5 OR9Q2 OR2M3	1.18e-15	340	20	10	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR4A8 OR2T4 OR4C11 OR4C16 OR6Y1 OR4A16 OR4C12 OR2M5 OR9Q2 OR2M3	1.29e-15	343	20	10	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR4A8 OR2T4 OR4C11 OR4C16 OR6Y1 OR4A16 OR4C12 OR2M5 OR9Q2 OR2M3	1.41e-15	346	20	10	14611657
Pubmed	Odorant and vomeronasal receptor genes in two mouse genome assemblies.	OR4A8 OR2T4 OR4C11 OR4C16 OR6Y1 OR4A16	2.85e-12	74	20	6	15081110
Pubmed	The human olfactory receptor gene family.	OR4A8 OR2T4 OR4C11 OR4C16 OR6Y1 OR4A16 OR4C12 OR2M5 OR2M3	7.20e-12	541	20	9	14983052
Pubmed	Differential stability of the crystallographic interfaces of mu- and kappa-opioid receptors.	OPRK1 OPRM1	3.14e-07	2	20	2	24651466
Pubmed	κ Opioid Receptor 1 Single Nucleotide Polymorphisms were Associated with the Methadone Dosage.	OPRK1 OPRM1	3.14e-07	2	20	2	31940240
Pubmed	Differential involvement of the mu and kappa opioid receptors in spatial learning.	OPRK1 OPRM1	3.14e-07	2	20	2	12884965
Pubmed	Morphine can produce analgesia via spinal kappa opioid receptors in the absence of mu opioid receptors.	OPRK1 OPRM1	3.14e-07	2	20	2	16530171
Pubmed	Involvement of µ-opioid Receptors and κ-opioid Receptors in Itch-related Scratching Behaviour of Imiquimod-induced Psoriasis-like Dermatitis in Mice.	OPRK1 OPRM1	3.14e-07	2	20	2	28512665
Pubmed	Association of OPRK1 and OPRM1 methylation with mild cognitive impairment in Xinjiang Han and Uygur populations.	OPRK1 OPRM1	3.14e-07	2	20	2	27838450
Pubmed	Epistatic effects between variants of kappa-opioid receptor gene and A118G of mu-opioid receptor gene increase susceptibility to addiction in Indian population.	OPRK1 OPRM1	3.14e-07	2	20	2	22138325
Pubmed	Mu- and kappa-opioids induce the differentiation of embryonic stem cells to neural progenitors.	OPRK1 OPRM1	3.14e-07	2	20	2	16954126
Pubmed	Opioid Receptors in Psoriatic Skin: Relationship with Itch.	OPRK1 OPRM1	3.14e-07	2	20	2	27958613
Pubmed	Deletion of mu- and kappa-opioid receptors in mice changes epidermal hypertrophy, density of peripheral nerve endings, and itch behavior.	OPRK1 OPRM1	3.14e-07	2	20	2	17185983
Pubmed	Ligand directed signaling differences between rodent and human κ-opioid receptors.	OPRK1 OPRM1	3.14e-07	2	20	2	23086943
Pubmed	Modelling the PKPD of oxycodone in experimental pain - Impact of opioid receptor polymorphisms.	OPRK1 OPRM1	9.42e-07	3	20	2	26946441
Pubmed	Association between human opioid receptor genes polymorphisms and pressure pain sensitivity in females*.	OPRK1 OPRM1	9.42e-07	3	20	2	19032295
Pubmed	OPRM1, OPRK1, and COMT genetic polymorphisms associated with opioid effects on experimental pain: a randomized, double-blind, placebo-controlled study.	OPRK1 OPRM1	9.42e-07	3	20	2	31806881
Pubmed	Nociception increases during opioid infusion in opioid receptor triple knock-out mice.	OPRK1 OPRM1	9.42e-07	3	20	2	17544222
Pubmed	The delta agonists DPDPE and deltorphin II recruit predominantly mu receptors to produce thermal analgesia: a parallel study of mu, delta and combinatorial opioid receptor knockout mice.	OPRK1 OPRM1	9.42e-07	3	20	2	15090050
Pubmed	Endogenous opioid receptor genes and alcohol dependence among Taiwanese Han.	OPRK1 OPRM1	9.42e-07	3	20	2	14745298
Pubmed	Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors.	OPRK1 OPRM1	9.42e-07	3	20	2	8114680
Pubmed	Opioid receptor characterisation of neuronally stimulated isolated human vas deferens.	OPRK1 OPRM1	9.42e-07	3	20	2	22752269
Pubmed	Improgan, a cimetidine analog, induces morphine-like antinociception in opioid receptor-knockout mice.	OPRK1 OPRM1	9.42e-07	3	20	2	11032994
Pubmed	Quantitative autoradiography of mu-,delta- and kappa1 opioid receptors in kappa-opioid receptor knockout mice.	OPRK1 OPRM1	9.42e-07	3	20	2	10082819
Pubmed	Systemic morphine treatment derails normal uterine receptivity, leading to embryo implantation failure in mice.	OPRK1 OPRM1	9.42e-07	3	20	2	25855262
Pubmed	Cell-specific actions of HIV-Tat and morphine on opioid receptor expression in glia.	OPRK1 OPRM1	9.42e-07	3	20	2	18338799
Pubmed	Opioid receptors: from binding sites to visible molecules in vivo.	OPRK1 OPRM1	9.42e-07	3	20	2	18718480
Pubmed	Effects of opioid receptor gene variation on targeted nalmefene treatment in heavy drinkers.	OPRK1 OPRM1	9.42e-07	3	20	2	18537939
Pubmed	Food reward-sensitive interaction of ghrelin and opioid receptor pathways in mesolimbic dopamine system.	OPRK1 OPRM1	9.42e-07	3	20	2	23220294
Pubmed	Acute antinociceptive responses in single and combinatorial opioid receptor knockout mice: distinct mu, delta and kappa tones.	OPRK1 OPRM1	9.42e-07	3	20	2	12603260
Pubmed	Long-term alterations in mu, delta and kappa opioidergic receptors following middle cerebral artery occlusion in mice.	OPRK1 OPRM1	9.42e-07	3	20	2	17676326
Pubmed	Distinct mu, delta, and kappa opioid receptor mechanisms underlie low sociability and depressive-like behaviors during heroin abstinence.	OPRK1 OPRM1	9.42e-07	3	20	2	24874714
Pubmed	Searching for evidence of genetic mediation of opioid withdrawal by opioid receptor gene polymorphisms.	OPRK1 OPRM1	9.42e-07	3	20	2	26692286
Pubmed	Opioid receptor gene (OPRM1, OPRK1, and OPRD1) variants and response to naltrexone treatment for alcohol dependence: results from the VA Cooperative Study.	OPRK1 OPRM1	9.42e-07	3	20	2	17374034
Pubmed	Genetic Variations of OPRM1, OPRK1, and COMT Genes and Their Possible Associations with Oral Pain in a Population from Argentina.	OPRK1 OPRM1	9.42e-07	3	20	2	30365572
Pubmed	Motivational effects of cannabinoids are mediated by mu-opioid and kappa-opioid receptors.	OPRK1 OPRM1	9.42e-07	3	20	2	11826143
Pubmed	Multiple OPR genes influence personality traits in substance dependent and healthy subjects in two American populations.	OPRK1 OPRM1	9.42e-07	3	20	2	18213616
Pubmed	Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site.	OPRK1 OPRM1	9.42e-07	3	20	2	33555255
Pubmed	Enhanced humoral response in kappa-opioid receptor knockout mice.	OPRK1 OPRM1	9.42e-07	3	20	2	12507774
Pubmed	Neurofilament proteins and cAMP pathway in brains of mu-, delta- or kappa-opioid receptor gene knock-out mice: effects of chronic morphine administration.	OPRK1 OPRM1	9.42e-07	3	20	2	14975676
Pubmed	Quantitative trait loci influencing morphine antinociception in four mapping populations.	OPRK1 OPRM1	9.42e-07	3	20	2	11420618
Pubmed	Immunosuppression by delta-opioid antagonist naltrindole: delta- and triple mu/delta/kappa-opioid receptor knockout mice reveal a nonopioid activity.	OPRK1 OPRM1	9.42e-07	3	20	2	11504820
Pubmed	No evidence for G-protein-coupled epsilon receptor in the brain of triple opioid receptor knockout mouse.	OPRK1 OPRM1	9.42e-07	3	20	2	15178356
Pubmed	Autoradiography of opioid and ORL1 ligands in opioid receptor triple knockout mice.	OPRK1 OPRM1	9.42e-07	3	20	2	12431223
Pubmed	Differential coupling of mu-, delta-, and kappa-opioid receptors to G alpha16-mediated stimulation of phospholipase C.	OPRK1 OPRM1	9.42e-07	3	20	2	9572309
Pubmed	The efficacy of Dynorphin fragments at the κ, μ and δ opioid receptor in transfected HEK cells and in an animal model of unilateral peripheral inflammation.	OPRK1 OPRM1	9.42e-07	3	20	2	28049031
Pubmed	Heterodimerization of mu and delta opioid receptors: A role in opiate synergy.	OPRK1 OPRM1	9.42e-07	3	20	2	11069979
Pubmed	Formalin-induced pain is reduced in sigma(1) receptor knockout mice.	OPRK1 OPRM1	9.42e-07	3	20	2	15777781
Pubmed	Essential role of mu opioid receptor in the regulation of delta opioid receptor-mediated antihyperalgesia.	OPRK1 OPRM1	1.88e-06	4	20	2	17997230
Pubmed	High-throughput microarray detection of olfactory receptor gene expression in the mouse.	OR2M5 OR2M3	1.88e-06	4	20	2	15377787
Pubmed	Multiple opioid receptor-like genes are identified in diverse vertebrate phyla.	OPRK1 OPRM1	1.88e-06	4	20	2	8941707
Pubmed	Activation of delta-, kappa-, and mu-opioid receptors induces phosphorylation of tuberin in transfected HEK 293 cells and native cells.	OPRK1 OPRM1	1.88e-06	4	20	2	16053916
Pubmed	Interactions of opioid and chemokine receptors: oligomerization of mu, kappa, and delta with CCR5 on immune cells.	OPRK1 OPRM1	1.88e-06	4	20	2	12413885
Pubmed	Developmental expression of the mu, kappa, and delta opioid receptor mRNAs in mouse.	OPRK1 OPRM1	1.88e-06	4	20	2	9502813
Pubmed	Quantitative autoradiographic mapping of the ORL1, mu-, delta- and kappa-receptors in the brains of knockout mice lacking the ORL1 receptor gene.	OPRK1 OPRM1	1.88e-06	4	20	2	11430857
Pubmed	A Dual Noradrenergic Mechanism for the Relief of Neuropathic Allodynia by the Antidepressant Drugs Duloxetine and Amitriptyline.	OPRK1 OPRM1	1.88e-06	4	20	2	30249798
Pubmed	Ligand-directed c-Jun N-terminal kinase activation disrupts opioid receptor signaling.	OPRK1 OPRM1	3.14e-06	5	20	2	20534436
Pubmed	Identification and characterization of novel candidate compounds targeting 6- and 7-transmembrane μ-opioid receptor isoforms.	OPRK1 OPRM1	3.14e-06	5	20	2	33782947
Pubmed	Variations in opioid receptor genes in neonatal abstinence syndrome.	OPRK1 OPRM1	3.14e-06	5	20	2	26233486
Pubmed	Expression of opioid receptors and ligands in pregnant mouse uterus and placenta.	OPRK1 OPRM1	4.71e-06	6	20	2	9746745
Pubmed	Genetic susceptibility to heroin addiction: a candidate gene association study.	OPRK1 OPRM1	4.71e-06	6	20	2	18518925
Pubmed	Opioid receptor gene expression in dopamine transporter knock-out mice in adult and during development.	OPRK1 OPRM1	4.71e-06	6	20	2	12044478
Pubmed	Preimplantation mouse embryo is a target for opioid ligand-receptor signaling.	OPRK1 OPRM1	8.78e-06	8	20	2	24855103
Pubmed	SERCA pump activity is physiologically regulated by presenilin and regulates amyloid beta production.	CHRND PSEN1	8.78e-06	8	20	2	18591429
Pubmed	Murine chromosomal location of the mu and kappa opioid receptor genes.	OPRK1 OPRM1	1.13e-05	9	20	2	7959748
Pubmed	Chromosomal localization of opioid peptide and receptor genes in the mouse.	OPRK1 OPRM1	2.07e-05	12	20	2	7752808
Pubmed	Identification of a novel family of G protein-coupled receptor associated sorting proteins.	OPRK1 OPRM1	2.85e-05	14	20	2	15086532
Pubmed	MOR is not enough: identification of novel mu-opioid receptor interacting proteins using traditional and modified membrane yeast two-hybrid screens.	OPRK1 OPRM1	3.28e-05	15	20	2	23840749
Pubmed	A growth factor attenuates HIV-1 Tat and morphine induced damage to human neurons: implication in HIV/AIDS-drug abuse cases.	OPRK1 OPRM1	4.25e-05	17	20	2	21483469
Pubmed	Gsh2 and Pax6 play complementary roles in dorsoventral patterning of the mammalian telencephalon.	OPRK1 OPRM1	7.21e-05	22	20	2	11124115
Pubmed	Dissociation of heterotrimeric g proteins in cells.	OPRK1 OPRM1 MTNR1A	1.43e-04	179	20	3	18577758
Pubmed	Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization.	IL21 TLR6	1.54e-04	32	20	2	23817571
Pubmed	Personal receptor repertoires: olfaction as a model.	OR4A8 OR4C16	2.18e-04	38	20	2	22908908
Pubmed	Expert curation of the human and mouse olfactory receptor gene repertoires identifies conserved coding regions split across two exons.	OR6Y1 OR2M3	3.20e-04	46	20	2	32126975
Pubmed	A large-scale candidate gene association study of age at menarche and age at natural menopause.	CHRND OPRK1 OPRM1	5.05e-04	275	20	3	20734064
Pubmed	A multivariate analysis of 59 candidate genes in personality traits: the temperament and character inventory.	OPRM1 PSEN1	5.09e-04	58	20	2	11140838
Interaction	GJA4 interactions	OPRK1 OPRM1	1.22e-05	10	11	2	int:GJA4
Interaction	WLS interactions	CHRND OPRK1 OPRM1	1.53e-05	93	11	3	int:WLS
Interaction	GNA15 interactions	OPRK1 OPRM1	8.74e-05	26	11	2	int:GNA15
Interaction	OPRD1 interactions	OPRK1 OPRM1	3.40e-04	51	11	2	int:OPRD1
Interaction	CLEC7A interactions	SPINT1 OPRM1	3.82e-04	54	11	2	int:CLEC7A
Interaction	CCDC167 interactions	OPRM1 MTNR1A	4.56e-04	59	11	2	int:CCDC167
Interaction	CTXN3 interactions	TSPAN12 OPRM1	4.71e-04	60	11	2	int:CTXN3
Interaction	SERP2 interactions	OPRM1 PSEN1	5.19e-04	63	11	2	int:SERP2
Interaction	DEGS1 interactions	OPRM1 PSEN1	5.87e-04	67	11	2	int:DEGS1
Interaction	GPRASP1 interactions	OPRK1 OPRM1	5.87e-04	67	11	2	int:GPRASP1
Interaction	EMP3 interactions	TSPAN12 OPRM1	6.23e-04	69	11	2	int:EMP3
Interaction	PMP22 interactions	TSPAN12 OPRM1	6.41e-04	70	11	2	int:PMP22
Interaction	DOK4 interactions	OPRK1 OPRM1	7.16e-04	74	11	2	int:DOK4
Interaction	ADAM33 interactions	SPINT1 OPRM1	8.16e-04	79	11	2	int:ADAM33
Interaction	COG1 interactions	OPRM1 MTNR1A	8.16e-04	79	11	2	int:COG1
Interaction	MAL interactions	SPINT1 OPRM1	8.78e-04	82	11	2	int:MAL
Interaction	SLC38A7 interactions	SPINT1 OPRM1	1.01e-03	88	11	2	int:SLC38A7
Interaction	SIAH2 interactions	OPRK1 OPRM1	1.41e-03	104	11	2	int:SIAH2
Cytoband	Ensembl 112 genes in cytogenetic band chr11q11	OR4A8 OR4C11 OR4C16 OR4A16	2.37e-09	40	20	4	chr11q11
Cytoband	11q11	OR4C11 OR4C16 OR4A16	1.13e-06	47	20	3	11q11
Cytoband	1q44	OR2T4 OR2M5 OR2M3	1.48e-05	110	20	3	1q44
Cytoband	Ensembl 112 genes in cytogenetic band chr1q44	OR2T4 OR2M5 OR2M3	2.33e-05	128	20	3	chr1q44
Cytoband	11p11.12	OR4A8 OR4C12	1.54e-04	42	20	2	11p11.12
GeneFamily	Olfactory receptors, family 4	OR4A8 OR4C11 OR4C16 OR4A16 OR4C12	1.36e-07	129	18	5	151
GeneFamily	Opioid receptors	OPRK1 OPRM1	5.61e-06	4	18	2	245
GeneFamily	Olfactory receptors, family 2	OR2T4 OR2M5 OR2M3	1.81e-04	113	18	3	149
Coexpression	DESCARTES_MAIN_FETAL_LIMBIC_SYSTEM_NEURONS	OPRK1 OPRM1	2.60e-05	12	17	2	M40089
Coexpression	GSE3982_NEUTROPHIL_VS_EFF_MEMORY_CD4_TCELL_UP	ORAI3 TLR6 MTNR1A	2.71e-04	199	17	3	M5526
Coexpression	GSE3691_IFN_PRODUCING_KILLER_DC_VS_CONVENTIONAL_DC_SPLEEN_DN	TSPAN12 SPINT1 OPRK1	2.75e-04	200	17	3	M6366
Coexpression	GSE17721_4_VS_24H_CPG_BMDC_UP	TSPAN12 CHRND TLR6	2.75e-04	200	17	3	M4130
Coexpression	GSE10325_CD4_TCELL_VS_MYELOID_DN	SPINT1 ORAI3 TLR6	2.75e-04	200	17	3	M3079
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Myh8_Fibin\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	OPRK1 OPRM1 MTNR1A	1.70e-05	113	20	3	feb3c6a7723263d58e5ce020a0097fedfcf78ca8
ToppCell	3'-GW_trimst-1-SmallIntestine-Epithelial-neuro-epithelial-Progenitor_(NEUROG3+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SPINT1 CHRND OPRK1	7.41e-05	185	20	3	2088e82e0febdcf05618d3db913d00e2e87812f4
ToppCell	wk_15-18-Epithelial-Airway_epithelial_progenitor-epi-airway_progenitor_early\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	TSPAN12 SPINT1 OPRK1	8.40e-05	193	20	3	de569c6e507856fd3ac2311f246cb597074ed30c
ToppCell	wk_08-11-Epithelial-Airway_epithelial_progenitor-epi-prox-progenitor_intermediate_\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	TSPAN12 SPINT1 OPRK1	9.06e-05	198	20	3	1eb49b853a9e144e840c660060473fc7873f6478
ToppCell	wk_15-18-Epithelial-Proximal_epithelial-Late_airway_progenitor\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	TSPAN12 SPINT1 OPRK1	9.19e-05	199	20	3	494461665f945ce6c97299c58f7785e90dec5812
Computational	Vesicular transport / synapse genes.	CHRND OPRK1	5.66e-04	82	5	2	MODULE_274
Drug	Dcfpe	SPINT1 OPRK1 OPRM1	5.47e-07	21	18	3	CID003082858
Drug	N-propargyl	OPRK1 OPRM1	5.90e-07	2	18	2	ctd:C440369
Drug	N-(3-iodoprop-(2)-enyl)	OPRK1 OPRM1	5.90e-07	2	18	2	ctd:C440388
Drug	methyl 2-(3-ethyl-7a,12a-(epoxyethanoxy)-9-fluoro-1,2,3,4,6,7,12,12b-octahydro-8-methoxyindolo(2,3-a)quinolizin-2-yl)-3-methoxyacrylate	OPRK1 OPRM1	5.90e-07	2	18	2	ctd:C533093
Drug	Cyclazocine	OPRK1 OPRM1	5.90e-07	2	18	2	ctd:D003496
Drug	paynantheine	OPRK1 OPRM1	5.90e-07	2	18	2	ctd:C580857
Drug	3-dadh-ol	OPRK1 OPRM1	5.90e-07	2	18	2	CID000128663
Drug	Dezocine	OPRK1 OPRM1	5.90e-07	2	18	2	DB01209
Drug	dihydroheroin	OPRK1 OPRM1	5.90e-07	2	18	2	CID005359460
Drug	GUM1 compound	OPRK1 OPRM1	5.90e-07	2	18	2	ctd:C000611307
Drug	P 7521	OPRK1 OPRM1	5.90e-07	2	18	2	CID000146384
Drug	tetrahydro-3-isoquinolinecarboxylic acid	SPINT1 OPRK1 OPRM1	9.44e-07	25	18	3	CID000095489
Drug	Alvimopan	OPRK1 OPRM1	1.77e-06	3	18	2	DB06274
Drug	Pentazocine	OPRK1 OPRM1	1.77e-06	3	18	2	ctd:D010423
Drug	Buprenorphine	OPRK1 OPRM1	1.77e-06	3	18	2	DB00921
Drug	dextrallorphan	OPRK1 OPRM1	1.77e-06	3	18	2	ctd:C044130
Drug	cyclorphan	OPRK1 OPRM1	1.77e-06	3	18	2	ctd:C084603
Drug	Heroin	OPRK1 OPRM1	1.77e-06	3	18	2	DB01452
Drug	3-Methylthiofentanyl	OPRK1 OPRM1	1.77e-06	3	18	2	DB01439
Drug	14-phenylpropoxymetopon	OPRK1 OPRM1	1.77e-06	3	18	2	ctd:C478565
Drug	morphine-7,8-oxide	OPRK1 OPRM1	1.77e-06	3	18	2	CID005491901
Drug	TRK 820	OPRK1 OPRM1	1.77e-06	3	18	2	ctd:C111212
Drug	Levorphanol	OPRK1 OPRM1	1.77e-06	3	18	2	DB00854
Drug	Levorphanol	OPRK1 OPRM1	1.77e-06	3	18	2	ctd:D007981
Drug	Levallorphan	OPRK1 OPRM1	1.77e-06	3	18	2	ctd:D007977
Drug	Remifentanil	OPRK1 OPRM1	1.77e-06	3	18	2	DB00899
Drug	Nalbuphine	OPRK1 OPRM1	1.77e-06	3	18	2	DB00844
Drug	Fentanyl	OPRK1 OPRM1	1.77e-06	3	18	2	DB00813
Drug	Oxycodone	OPRK1 OPRM1	1.77e-06	3	18	2	DB00497
Drug	Hydromorphone	OPRK1 OPRM1	1.77e-06	3	18	2	DB00327
Drug	Codeine	OPRK1 OPRM1	1.77e-06	3	18	2	DB00318
Drug	Lactoferroxin C	OPRK1 OPRM1	1.77e-06	3	18	2	CID000192714
Drug	Lactoferroxin B	OPRK1 OPRM1	1.77e-06	3	18	2	CID000192715
Drug	Lactoferroxin A	OPRK1 OPRM1	1.77e-06	3	18	2	CID000192716
Drug	Sufentanil	OPRK1 OPRM1	1.77e-06	3	18	2	DB00708
Drug	Propoxyphene	OPRK1 OPRM1	1.77e-06	3	18	2	DB00647
Drug	Butorphanol	OPRK1 OPRM1	1.77e-06	3	18	2	DB00611
Drug	bromadoline	OPRK1 OPRM1	1.77e-06	3	18	2	CID000054753
Drug	Carfentanil	OPRK1 OPRM1	1.77e-06	3	18	2	DB01535
Drug	Butorphanol	OPRK1 OPRM1	1.77e-06	3	18	2	ctd:D002077
Drug	Pentazocine	OPRK1 OPRM1	1.77e-06	3	18	2	DB00652
Drug	Morphine	OPRK1 OPRM1	1.77e-06	3	18	2	DB00295
Drug	Hydrocodone	OPRK1 OPRM1	1.77e-06	3	18	2	ctd:D006853
Drug	3-Methylfentanyl	OPRK1 OPRM1	1.77e-06	3	18	2	DB01571
Drug	7-hydroxymitragynine	OPRK1 OPRM1	3.54e-06	4	18	2	ctd:C482678
Drug	NSC1953	OPRK1 OPRM1	3.54e-06	4	18	2	CID000102946
Drug	3B-b	OPRK1 OPRM1	3.54e-06	4	18	2	CID000533975
Drug	Nalbuphine	OPRK1 OPRM1	3.54e-06	4	18	2	ctd:D009266
Drug	diphenoxylate	OPRK1 OPRM1	3.54e-06	4	18	2	CID000013505
Drug	Dynorphins	OPRK1 OPRM1	3.54e-06	4	18	2	ctd:D004399
Drug	Naltrexone	OPRK1 OPRM1	3.54e-06	4	18	2	DB00704
Drug	Meperidine	OPRK1 OPRM1	3.54e-06	4	18	2	ctd:D008614
Drug	Methadyl Acetate	OPRK1 OPRM1	3.54e-06	4	18	2	ctd:D008692
Drug	AC1L5BQM	OPRK1 OPRM1	3.54e-06	4	18	2	CID000174892
Drug	Diprenorphine	OPRK1 OPRM1	3.54e-06	4	18	2	DB01548
Drug	K 185	OPRK1 MTNR1A	5.89e-06	5	18	2	CID005311198
Drug	nalorphine-epoxide	OPRK1 OPRM1	5.89e-06	5	18	2	CID003086440
Drug	oxymorphamine	OPRK1 OPRM1	5.89e-06	5	18	2	CID000134844
Drug	Sc 39566	OPRK1 OPRM1	5.89e-06	5	18	2	CID000130018
Drug	nalmefene	OPRK1 OPRM1	5.89e-06	5	18	2	ctd:C038981
Drug	Naloxone	OPRK1 OPRM1	5.89e-06	5	18	2	DB01183
Drug	Dihydromorphine	OPRK1 OPRM1	5.89e-06	5	18	2	DB01565
Drug	AC1L2OET	OPRK1 OPRM1	8.84e-06	6	18	2	CID000125331
Drug	Etorphine	OPRK1 OPRM1	8.84e-06	6	18	2	DB01497
Drug	Loperamide	OPRK1 OPRM1	8.84e-06	6	18	2	DB00836
Drug	NSC612111	OPRK1 OPRM1	8.84e-06	6	18	2	CID000163346
Drug	RX8008M	OPRK1 OPRM1	8.84e-06	6	18	2	CID000162443
Drug	2-mercaptoacetate	OPRK1 OPRM1	1.24e-05	7	18	2	ctd:C017487
Drug	AC1L9PCU	OPRK1 OPRM1	1.24e-05	7	18	2	CID000451042
Drug	N-cyclopropylmethylnorazidomorphine	OPRK1 OPRM1	1.24e-05	7	18	2	CID005489191
Drug	beta-naltrexamine	OPRK1 OPRM1	1.24e-05	7	18	2	CID005486948
Drug	Pcl-dpdpe	OPRK1 OPRM1	1.24e-05	7	18	2	CID000159564
Drug	aminocyclohexanecarboxylic acid	OPRK1 OPRM1	1.24e-05	7	18	2	CID000171560
Drug	Tyr-ala-phe-gly	OPRK1 OPRM1	1.24e-05	7	18	2	CID005487532
Drug	Enkephalin, D-Penicillamine (2,5)-	OPRK1 OPRM1	1.24e-05	7	18	2	ctd:D020881
Drug	Dextrorphan	OPRK1 OPRM1	1.24e-05	7	18	2	ctd:D003917
Drug	MET-CAMO	OPRK1 OPRM1	1.24e-05	7	18	2	CID006450159
Drug	Dextropropoxyphene	OPRK1 OPRM1	1.24e-05	7	18	2	ctd:D011431
Drug	phenylmorphan	OPRK1 OPRM1	1.24e-05	7	18	2	CID000146306
Drug	NDTMB	OPRK1 OPRM1	1.24e-05	7	18	2	CID000134748
Drug	AC1L9NAZ	OPRK1 OPRM1 PSEN1 MTNR1A	1.54e-05	198	18	4	CID000449606
Drug	meperidine	OPRK1 OPRM1 PSEN1	1.60e-05	63	18	3	CID000004058
Drug	beta-MeTrp	SPINT1 OPRM1	1.65e-05	8	18	2	CID000065530
Drug	DIPPA	OPRK1 OPRM1	1.65e-05	8	18	2	CID000127914
Drug	ICI 204448	OPRK1 OPRM1	1.65e-05	8	18	2	CID000003683
Drug	14-methoxymetopon	OPRK1 OPRM1	1.65e-05	8	18	2	CID005486940
Drug	Oxymorphone hydrazone	OPRK1 OPRM1	1.65e-05	8	18	2	CID009577748
Drug	U 69593	OPRK1 OPRM1	1.65e-05	8	18	2	ctd:C045444
Drug	metazocine	OPRK1 OPRM1	1.65e-05	8	18	2	CID000062518
Drug	KT-89	OPRK1 OPRM1	1.65e-05	8	18	2	CID005748450
Drug	Tyr-D-Ala-Gly-Phe-Leu-chloromethyl ketone	OPRK1 OPRM1	1.65e-05	8	18	2	CID005492572
Drug	binaltorphimine	OPRK1 OPRM1	1.65e-05	8	18	2	CID005484197
Drug	AC1L1B1Q	OPRK1 OPRM1	1.65e-05	8	18	2	CID000001246
Drug	N-methyl nalorphine	OPRK1 OPRM1	1.65e-05	8	18	2	CID005748235
Drug	AC1LBBLW	OPRK1 OPRM1	1.65e-05	8	18	2	CID000579851
Drug	Tramadol	OPRK1 OPRM1	2.12e-05	9	18	2	DB00193
Drug	AC1LD4H9	OPRK1 OPRM1	2.12e-05	9	18	2	CID000611919
Drug	meptazinol	OPRK1 OPRM1	2.12e-05	9	18	2	CID000041049
Drug	MRZ 2549	OPRK1 OPRM1	2.12e-05	9	18	2	CID000134837
Drug	M 285	OPRK1 OPRM1	2.12e-05	9	18	2	CID000020435
Disease	Mental Depression	OPRK1 OPRM1 PSEN1	4.67e-04	254	18	3	C0011570
Disease	Depressive disorder	OPRK1 OPRM1 PSEN1	6.80e-04	289	18	3	C0011581
Disease	dilated cardiomyopathy (implicated_via_orthology)	ORAI3 PSEN1	1.08e-03	80	18	2	DOID:12930 (implicated_via_orthology)
Disease	Visual seizure	OPRK1 OPRM1	1.71e-03	101	18	2	C0270824
Disease	Epileptic drop attack	OPRK1 OPRM1	1.71e-03	101	18	2	C0270846
Disease	Generalized seizures	OPRK1 OPRM1	1.71e-03	101	18	2	C0234533
Disease	Clonic Seizures	OPRK1 OPRM1	1.71e-03	101	18	2	C0234535
Disease	Vertiginous seizure	OPRK1 OPRM1	1.71e-03	101	18	2	C0422855
Disease	Gustatory seizure	OPRK1 OPRM1	1.71e-03	101	18	2	C0422854
Disease	Seizures, Somatosensory	OPRK1 OPRM1	1.71e-03	101	18	2	C0422850
Disease	Olfactory seizure	OPRK1 OPRM1	1.71e-03	101	18	2	C0422853
Disease	Seizures, Auditory	OPRK1 OPRM1	1.71e-03	101	18	2	C0422852
Disease	Generalized Absence Seizures	OPRK1 OPRM1	1.71e-03	101	18	2	C4505436
Disease	Convulsive Seizures	OPRK1 OPRM1	1.71e-03	101	18	2	C0751494
Disease	Seizures, Sensory	OPRK1 OPRM1	1.71e-03	101	18	2	C0751496
Disease	Atonic Absence Seizures	OPRK1 OPRM1	1.71e-03	101	18	2	C0751123
Disease	Complex partial seizures	OPRK1 OPRM1	1.71e-03	101	18	2	C0149958
Disease	Single Seizure	OPRK1 OPRM1	1.71e-03	101	18	2	C0751110
Disease	Epileptic Seizures	OPRK1 OPRM1	1.71e-03	101	18	2	C4317109
Disease	Jacksonian Seizure	OPRK1 OPRM1	1.71e-03	101	18	2	C0022333
Disease	Non-epileptic convulsion	OPRK1 OPRM1	1.71e-03	101	18	2	C0751056
Disease	Nonepileptic Seizures	OPRK1 OPRM1	1.71e-03	101	18	2	C3495874
Disease	Tonic Seizures	OPRK1 OPRM1	1.75e-03	102	18	2	C0270844
Disease	Absence Seizures	OPRK1 OPRM1	1.75e-03	102	18	2	C4316903
Disease	Convulsions	OPRK1 OPRM1	1.75e-03	102	18	2	C4048158
Disease	Seizures, Focal	OPRK1 OPRM1	1.81e-03	104	18	2	C0751495
Disease	Myoclonic Seizures	OPRK1 OPRM1	1.81e-03	104	18	2	C4317123
Disease	Tonic - clonic seizures	OPRK1 OPRM1	1.81e-03	104	18	2	C0494475
Disease	Cocaine-Related Disorders	OPRK1 OPRM1	2.29e-03	117	18	2	C0236736
Disease	Cocaine Abuse	OPRK1 OPRM1	2.69e-03	127	18	2	C0009171
Disease	Cocaine Dependence	OPRK1 OPRM1	3.21e-03	139	18	2	C0600427

Protein segments in the cluster

Peptide	Gene	Start	Entry
TMVVVICVIVLNIHF	CHRND	321	Q07001
IMVPVGLVFVAFALH	ORAI3	251	Q9BRQ5
EVVIIVFALFVMPAC	OR9Q2	196	Q8NGE9
VFALFVMPACILVIL	OR9Q2	201	Q8NGE9
ICVFIFAFIMPVLII	OPRM1	236	P35372
HIIVVVLFFVPCIFV	OR4C12	241	Q96R67
HIIVVALVFVPCIFM	OR4A16	241	Q8NH70
ICCIVMIVFPVAIII	OR2M3	201	Q8NG83
EKVLFICCIVMIVFP	OR2M5	196	A3KFT3
ICCIVMIVFPVAIII	OR2M5	201	A3KFT3
PALLCVVIFVVFLMA	OR2T4	56	Q8NH00
HIIVVILFFGPCIFI	OR4C11	241	Q6IEV9
IVICLMVIFLGTLVH	IL21	11	Q9HBE4
HIIVVILFFGPCIFM	OR4C16	241	Q8NGL9
MKICVFIFAFVIPVL	OPRK1	226	P41145
HFIMVILFFVPCIFL	OR4A8	241	P0C604
HVIMLFVPVTLCMVV	PSEN1	81	P49768
FVPVTLCMVVVVATI	PSEN1	86	P49768
FLALMVIAIPLCVVV	OR6Y1	206	Q8NGX8
MAVAVFLVICIVVVV	SPINT1	466	O43278
PVVHPVMIAVCCFLI	TSPAN12	61	O95859
EPIVKSFHFVCLMII	TLR6	6	Q9Y2C9
VVVFHFLVPMIIVIF	MTNR1A	191	P48039