Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	zinc ion binding	UBR5 RC3H1 NFX1 NFXL1 KMT2A ZNFX1 ZMYM3 ZCCHC3 WDFY1 POLR3A	1.64e-04	891	56	10	GO:0008270
GeneOntologyMolecularFunction	frizzled binding	WNT3A WNT10A LRP6	2.22e-04	42	56	3	GO:0005109
GeneOntologyMolecularFunction	transition metal ion binding	UBR5 RC3H1 CIAPIN1 NFX1 NFXL1 KMT2A ZNFX1 ZMYM3 ZCCHC3 WDFY1 POLR3A	3.98e-04	1189	56	11	GO:0046914
GeneOntologyMolecularFunction	diacylglycerol binding	RASGRP3 DGKD	9.04e-04	16	56	2	GO:0019992
GeneOntologyMolecularFunction	low-density lipoprotein particle receptor activity	LRP6 LRP1B	9.04e-04	16	56	2	GO:0005041
GeneOntologyBiologicalProcess	Wnt signaling pathway involved in forebrain neuroblast division	WNT3A LRP6	6.98e-06	2	55	2	GO:0021874
GeneOntologyBiologicalProcess	mammary gland development	RLN2 SLIT2 EGF WNT3A LRP6	7.12e-05	162	55	5	GO:0030879
GeneOntologyBiologicalProcess	axis elongation involved in somitogenesis	WNT3A LRP6	1.04e-04	6	55	2	GO:0090245
GeneOntologyBiologicalProcess	response to virus	ZDHHC11B ZNF175 ZNFX1 ZDHHC11 ITGB8 ZCCHC3 POLR3A	1.30e-04	425	55	7	GO:0009615
GeneOntologyBiologicalProcess	forebrain neuroblast division	WNT3A LRP6	1.45e-04	7	55	2	GO:0021873
GeneOntologyBiologicalProcess	roof of mouth development	FRAS1 WNT3A LRP6 ITGB8	1.71e-04	104	55	4	GO:0060021
GeneOntologyCellularComponent	Wnt-Frizzled-LRP5/6 complex	WNT3A LRP6	6.52e-05	5	54	2	GO:1990851
Domain	ZnF_NFX	NFX1 NFXL1 ZNFX1	2.42e-08	3	55	3	SM00438
Domain	zf-NF-X1	NFX1 NFXL1 ZNFX1	2.42e-08	3	55	3	PF01422
Domain	Znf_NFX1	NFX1 NFXL1 ZNFX1	2.42e-08	3	55	3	IPR000967
Domain	EGF	SLIT2 FRAS1 FBN1 EGF ADAM9 LRP6 LRP1B ITGB8	4.08e-07	235	55	8	SM00181
Domain	EGF-like_dom	SLIT2 FRAS1 FBN1 EGF ADAM21 ADAM9 LRP6 LRP1B	6.32e-07	249	55	8	IPR000742
Domain	EGF_1	SLIT2 FBN1 EGF ADAM21 ADAM9 LRP6 LRP1B ITGB8	7.57e-07	255	55	8	PS00022
Domain	EGF-like_CS	SLIT2 FBN1 EGF ADAM21 ADAM9 LRP6 LRP1B ITGB8	9.02e-07	261	55	8	IPR013032
Domain	EGF_2	SLIT2 FBN1 EGF ADAM21 ADAM9 LRP6 LRP1B ITGB8	1.01e-06	265	55	8	PS01186
Domain	EGF_3	SLIT2 FBN1 EGF ADAM21 ADAM9 LRP6 LRP1B	5.54e-06	235	55	7	PS50026
Domain	Ldl_recept_b	EGF LRP6 LRP1B	8.60e-06	14	55	3	PF00058
Domain	LDLRB	EGF LRP6 LRP1B	8.60e-06	14	55	3	PS51120
Domain	KRAB	ZNF43 ZNF175 ZNF735 ZNF667 ZNF814 ZNF786 ZNF222 ZNF445	9.35e-06	358	55	8	PS50805
Domain	KRAB	ZNF43 ZNF175 ZNF735 ZNF667 ZNF814 ZNF786 ZNF222 ZNF445	9.35e-06	358	55	8	PF01352
Domain	LY	EGF LRP6 LRP1B	1.07e-05	15	55	3	SM00135
Domain	LDLR_classB_rpt	EGF LRP6 LRP1B	1.07e-05	15	55	3	IPR000033
Domain	KRAB	ZNF43 ZNF175 ZNF735 ZNF667 ZNF814 ZNF786 ZNF222 ZNF445	1.16e-05	369	55	8	SM00349
Domain	KRAB	ZNF43 ZNF175 ZNF735 ZNF667 ZNF814 ZNF786 ZNF222 ZNF445	1.19e-05	370	55	8	IPR001909
Domain	Znf_C2H2	ZNF137P ZNF43 ZNF175 ZNF735 ZNF667 ADAMTS17 ZNF814 ZNF397 ZNF786 ZNF222 ZNF445	1.88e-05	805	55	11	IPR007087
Domain	C1_1	KSR1 RASGRP3 DGKD STAC	2.37e-05	57	55	4	PF00130
Domain	zf-C2H2	ZNF137P ZNF43 ZNF175 ZNF735 ZNF667 ZNF814 ZNF397 ZNF786 ZNF222 ZNF445	2.99e-05	693	55	10	PF00096
Domain	ZF_DAG_PE_1	KSR1 RASGRP3 DGKD STAC	3.75e-05	64	55	4	PS00479
Domain	ZF_DAG_PE_2	KSR1 RASGRP3 DGKD STAC	3.75e-05	64	55	4	PS50081
Domain	C1	KSR1 RASGRP3 DGKD STAC	3.99e-05	65	55	4	SM00109
Domain	PE/DAG-bd	KSR1 RASGRP3 DGKD STAC	4.24e-05	66	55	4	IPR002219
Domain	ACR	ADAM21 ADAM9 ADAMTS17	6.72e-05	27	55	3	SM00608
Domain	ADAM_Cys-rich	ADAM21 ADAM9 ADAMTS17	6.72e-05	27	55	3	IPR006586
Domain	ZINC_FINGER_C2H2_2	ZNF137P ZNF43 ZNF175 ZNF735 ZNF667 ZNF814 ZNF397 ZNF786 ZNF222 ZNF445	7.67e-05	775	55	10	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF137P ZNF43 ZNF175 ZNF735 ZNF667 ZNF814 ZNF397 ZNF786 ZNF222 ZNF445	7.84e-05	777	55	10	PS00028
Domain	FYVE	ANKFY1 WDFY2 WDFY1	8.36e-05	29	55	3	PF01363
Domain	FYVE	ANKFY1 WDFY2 WDFY1	8.36e-05	29	55	3	SM00064
Domain	Growth_fac_rcpt_	FRAS1 FBN1 EGF CRIM1 LRP1B	9.47e-05	156	55	5	IPR009030
Domain	ZnF_C2H2	ZNF137P ZNF43 ZNF175 ZNF735 ZNF667 ZNF814 ZNF397 ZNF786 ZNF222 ZNF445	1.08e-04	808	55	10	SM00355
Domain	Znf_FYVE-rel	ANKFY1 WDFY2 WDFY1	1.36e-04	34	55	3	IPR017455
Domain	-	ZNF43 ZNF175 ZNF735 ZNF667 ZNF814 ZNF397 ZNF786 ZNF222 ZNF445	1.50e-04	679	55	9	3.30.160.60
Domain	Znf_C2H2/integrase_DNA-bd	ZNF43 ZNF175 ZNF735 ZNF667 ZNF814 ZNF397 ZNF786 ZNF222 ZNF445	1.76e-04	694	55	9	IPR013087
Domain	Znf_FYVE	ANKFY1 WDFY2 WDFY1	1.89e-04	38	55	3	IPR000306
Domain	EGF_Ca-bd_CS	SLIT2 FBN1 EGF LRP1B	1.90e-04	97	55	4	IPR018097
Domain	Peptidase_M12B_N	ADAM21 ADAM9 ADAMTS17	2.05e-04	39	55	3	IPR002870
Domain	Pep_M12B_propep	ADAM21 ADAM9 ADAMTS17	2.05e-04	39	55	3	PF01562
Domain	-	EGF LRP6 LRP1B	2.05e-04	39	55	3	2.120.10.30
Domain	EGF_CA	SLIT2 FBN1 EGF LRP1B	2.06e-04	99	55	4	PS01187
Domain	ASX_HYDROXYL	SLIT2 FBN1 EGF LRP1B	2.14e-04	100	55	4	PS00010
Domain	DISINTEGRIN_1	ADAM21 ADAM9 ADAMTS17	2.21e-04	40	55	3	PS00427
Domain	Reprolysin	ADAM21 ADAM9 ADAMTS17	2.21e-04	40	55	3	PF01421
Domain	ZF_FYVE	ANKFY1 WDFY2 WDFY1	2.21e-04	40	55	3	PS50178
Domain	ADAM_MEPRO	ADAM21 ADAM9 ADAMTS17	2.21e-04	40	55	3	PS50215
Domain	DISINTEGRIN_2	ADAM21 ADAM9 ADAMTS17	2.21e-04	40	55	3	PS50214
Domain	Peptidase_M12B	ADAM21 ADAM9 ADAMTS17	2.21e-04	40	55	3	IPR001590
Domain	Disintegrin_dom	ADAM21 ADAM9 ADAMTS17	2.38e-04	41	55	3	IPR001762
Domain	EGF-type_Asp/Asn_hydroxyl_site	SLIT2 FBN1 EGF LRP1B	2.68e-04	106	55	4	IPR000152
Domain	6-blade_b-propeller_TolB-like	EGF LRP6 LRP1B	3.35e-04	46	55	3	IPR011042
Domain	EGF_CA	SLIT2 FBN1 EGF LRP1B	4.57e-04	122	55	4	SM00179
Domain	Znf_C2H2-like	ZNF43 ZNF175 ZNF735 ZNF667 ZNF814 ZNF397 ZNF786 ZNF222 ZNF445	4.84e-04	796	55	9	IPR015880
Domain	EGF-like_Ca-bd_dom	SLIT2 FBN1 EGF LRP1B	4.86e-04	124	55	4	IPR001881
Domain	EGF	SLIT2 EGF LRP6 LRP1B	5.16e-04	126	55	4	PF00008
Domain	EGF_extracell	ADAM9 LRP1B ITGB8	7.34e-04	60	55	3	IPR013111
Domain	EGF_2	ADAM9 LRP1B ITGB8	7.34e-04	60	55	3	PF07974
Domain	Znf_FYVE_PHD	ANKFY1 KMT2A WDFY2 WDFY1	9.20e-04	147	55	4	IPR011011
Domain	Disintegrin_CS	ADAM21 ADAM9	9.95e-04	16	55	2	IPR018358
Domain	ADAM_CR	ADAM21 ADAM9	1.26e-03	18	55	2	PF08516
Domain	Wnt	WNT3A WNT10A	1.41e-03	19	55	2	IPR005817
Domain	VWC_out	FRAS1 CRIM1	1.41e-03	19	55	2	SM00215
Domain	Wnt_CS	WNT3A WNT10A	1.41e-03	19	55	2	IPR018161
Domain	wnt	WNT3A WNT10A	1.41e-03	19	55	2	PF00110
Domain	WNT1	WNT3A WNT10A	1.41e-03	19	55	2	SM00097
Domain	WNT1	WNT3A WNT10A	1.41e-03	19	55	2	PS00246
Domain	-	ADAM21 ADAM9	1.56e-03	20	55	2	4.10.70.10
Domain	Disintegrin	ADAM21 ADAM9	1.72e-03	21	55	2	PF00200
Domain	DISIN	ADAM21 ADAM9	1.72e-03	21	55	2	SM00050
Domain	MetalloPept_cat_dom	ADAM21 ADAM9 ADAMTS17	1.75e-03	81	55	3	IPR024079
Domain	-	ADAM21 ADAM9 ADAMTS17	1.75e-03	81	55	3	3.40.390.10
Domain	EGF_CA	FBN1 EGF LRP1B	2.08e-03	86	55	3	PF07645
Domain	zf-C2H2_6	ZNF43 ZNF735 ZNF667 ZNF814 ZNF445	2.28e-03	314	55	5	PF13912
Domain	cEGF	FBN1 LRP1B	2.64e-03	26	55	2	IPR026823
Domain	cEGF	FBN1 LRP1B	2.64e-03	26	55	2	PF12662
Domain	ZINC_PROTEASE	ADAM21 ADAM9 ADAMTS17	3.02e-03	98	55	3	PS00142
Domain	VWC	FRAS1 CRIM1	3.06e-03	28	55	2	PF00093
Domain	VWFC_1	FRAS1 CRIM1	5.03e-03	36	55	2	PS01208
Domain	VWC	FRAS1 CRIM1	5.59e-03	38	55	2	SM00214
Domain	VWFC_2	FRAS1 CRIM1	5.59e-03	38	55	2	PS50184
Pathway	WP_WNT_SIGNALING_IN_KIDNEY_DISEASE	WNT3A WNT10A LRP6	1.64e-04	36	42	3	M39699
Pathway	KEGG_MEDICUS_VARIANT_FZD7_OVEREXPRESSION_TO_WNT_SIGNALING_PATHWAY	WNT3A WNT10A LRP6	1.78e-04	37	42	3	M47411
Pathway	REACTOME_SIGNALING_BY_RNF43_MUTANTS	WNT3A LRP6	2.40e-04	8	42	2	M27433
Pathway	KEGG_MEDICUS_VARIANT_LRP6_OVEREXPRESSION_TO_WNT_SIGNALING_PATHWAY	WNT3A WNT10A LRP6	3.20e-04	45	42	3	M47412
Pathway	KEGG_MEDICUS_REFERENCE_WNT_SIGNALING_PATHWAY	WNT3A WNT10A LRP6	3.41e-04	46	42	3	M47409
Pathway	WP_ESC_PLURIPOTENCY_PATHWAYS	EGF WNT3A WNT10A LRP6	3.83e-04	116	42	4	MM15863
Pathway	WP_EMBRYONIC_STEM_CELL_PLURIPOTENCY_PATHWAYS	EGF WNT3A WNT10A LRP6	3.95e-04	117	42	4	M39530
Pathway	WP_DEVELOPMENT_OF_URETERIC_COLLECTION_SYSTEM	SLIT2 FRAS1 CRIM1	7.48e-04	60	42	3	M40048
Pathway	REACTOME_NEGATIVE_REGULATION_OF_TCF_DEPENDENT_SIGNALING_BY_WNT_LIGAND_ANTAGONISTS	WNT3A LRP6	8.88e-04	15	42	2	M27273
Pathway	BIOCARTA_SPRY_PATHWAY	EGF SPRY4	1.01e-03	16	42	2	MM1500
Pathway	WP_BREAST_CANCER_PATHWAY	EGF WNT3A WNT10A LRP6	1.11e-03	154	42	4	M39739
Pathway	BIOCARTA_SPRY_PATHWAY	EGF SPRY4	1.15e-03	17	42	2	M1389
Pathway	PID_INTEGRIN5_PATHWAY	FBN1 ITGB8	1.15e-03	17	42	2	M212
Pathway	PID_BETA_CATENIN_DEG_PATHWAY	WNT3A LRP6	1.29e-03	18	42	2	M31
Pathway	KEGG_MEDICUS_REFERENCE_WNT_SIGNALING_MODULATION_WNT_ACYLATION	WNT3A WNT10A	1.43e-03	19	42	2	M47836
Pathway	REACTOME_REGULATION_OF_FZD_BY_UBIQUITINATION	WNT3A LRP6	1.59e-03	20	42	2	MM15155
Pathway	PID_WNT_CANONICAL_PATHWAY	WNT3A LRP6	1.59e-03	20	42	2	M90
Pathway	REACTOME_REGULATION_OF_FZD_BY_UBIQUITINATION	WNT3A LRP6	1.76e-03	21	42	2	M27401
Pubmed	Common variants in the trichohyalin gene are associated with straight hair in Europeans.	FRAS1 EGF WNT10A	2.32e-07	8	57	3	19896111
Pubmed	Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR.	ZNF43 ZNF175 ZNF814 ZNF445	1.30e-06	49	57	4	9630514
Pubmed	Wnt signaling activation and mammary gland hyperplasia in MMTV-LRP6 transgenic mice: implication for breast cancer tumorigenesis.	WNT3A LRP6	2.64e-06	2	57	2	19881541
Pubmed	ZDHHC11 and ZDHHC11B are critical novel components of the oncogenic MYC-miR-150-MYB network in Burkitt lymphoma.	ZDHHC11B ZDHHC11	2.64e-06	2	57	2	28331227
Pubmed	Wise retained in the endoplasmic reticulum inhibits Wnt signaling by reducing cell surface LRP6.	WNT3A LRP6	2.64e-06	2	57	2	17765217
Pubmed	Clathrin and AP2 are required for PtdIns(4,5)P2-mediated formation of LRP6 signalosomes.	WNT3A LRP6	2.64e-06	2	57	2	23400998
Pubmed	A novel ADAMTS17 variant that causes Weill-Marchesani syndrome 4 alters fibrillin-1 and collagen type I deposition in the extracellular matrix.	FBN1 ADAMTS17	2.64e-06	2	57	2	31726086
Pubmed	Analysis of endogenous LRP6 function reveals a novel feedback mechanism by which Wnt negatively regulates its receptor.	WNT3A LRP6	2.64e-06	2	57	2	17698587
Pubmed	Testis-specific hnRNP is expressed in colorectal cancer cells and accelerates cell growth mediating ZDHHC11 mRNA stabilization.	ZDHHC11B ZDHHC11	2.64e-06	2	57	2	35384384
Pubmed	Increased expression of Wnt2 and SFRP4 in Tsk mouse skin: role of Wnt signaling in altered dermal fibrillin deposition and systemic sclerosis.	FBN1 WNT3A WNT10A	5.44e-06	21	57	3	17943183
Pubmed	Tyrosine-based signal mediates LRP6 receptor endocytosis and desensitization of Wnt/β-catenin pathway signaling.	WNT3A LRP6	7.91e-06	3	57	2	25143377
Pubmed	Sequence and structural difference favors a distinct preference of Wnt3a binding with co-receptor LRP6.	WNT3A LRP6	7.91e-06	3	57	2	25425204
Pubmed	Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation.	WNT3A LRP6	7.91e-06	3	57	2	17569865
Pubmed	ZDHHC19 localizes to the cell membrane of spermatids and is involved in spermatogenesis†.	ZDHHC11B ZDHHC11	7.91e-06	3	57	2	34897408
Pubmed	Blocking of the interaction between Wnt proteins and their co-receptors contributes to the anti-tumor effects of adenovirus-mediated DKK3 in glioblastoma.	WNT3A LRP6	7.91e-06	3	57	2	25301448
Pubmed	Wnt3a-stimulated LRP6 phosphorylation is dependent upon arginine methylation of G3BP2.	WNT3A LRP6	7.91e-06	3	57	2	22357953
Pubmed	A novel mechanism for Wnt activation of canonical signaling through the LRP6 receptor.	WNT3A LRP6	7.91e-06	3	57	2	12897152
Pubmed	Anti-LRP5/6 VHHs promote differentiation of Wnt-hypersensitive intestinal stem cells.	WNT3A LRP6	7.91e-06	3	57	2	30664649
Pubmed	IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis.	WNT3A LRP6	1.58e-05	4	57	2	18528331
Pubmed	ZDHHC11 modulates innate immune response to DNA virus by mediating MITA-IRF3 association.	ZDHHC11B ZDHHC11	1.58e-05	4	57	2	29429998
Pubmed	Wnt5a regulates distinct signalling pathways by binding to Frizzled2.	WNT3A LRP6	1.58e-05	4	57	2	19910923
Pubmed	Wnt co-receptors Lrp5 and Lrp6 differentially mediate Wnt3a signaling in osteoblasts.	WNT3A LRP6	1.58e-05	4	57	2	29176883
Pubmed	Weill-Marchesani Syndrome	FBN1 ADAMTS17	1.58e-05	4	57	2	20301293
Pubmed	Tiki1 is required for head formation via Wnt cleavage-oxidation and inactivation.	WNT3A LRP6	1.58e-05	4	57	2	22726442
Pubmed	The low density lipoprotein receptor-1, LRP1, interacts with the human frizzled-1 (HFz1) and down-regulates the canonical Wnt signaling pathway.	WNT3A LRP6	1.58e-05	4	57	2	14739301
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	SNX14 FRAS1 FBN1 CRIM1 ADAM9 CIAPIN1 LRP6 TYW1 LRP1B ITGB8	2.29e-05	1201	57	10	35696571
Pubmed	Relaxin regulates fibrillin 2, but not fibrillin 1, mRNA and protein expression by human dermal fibroblasts and murine fetal skin.	RLN2 FBN1	2.63e-05	5	57	2	12590922
Pubmed	TRAF6 function as a novel co-regulator of Wnt3a target genes in prostate cancer.	WNT3A LRP6	2.63e-05	5	57	2	31262711
Pubmed	structural Studies of Wnts and identification of an LRP6 binding site.	WNT3A LRP6	2.63e-05	5	57	2	23791946
Pubmed	β-arrestin promotes Wnt-induced low density lipoprotein receptor-related protein 6 (Lrp6) phosphorylation via increased membrane recruitment of Amer1 protein.	WNT3A LRP6	2.63e-05	5	57	2	24265322
Pubmed	Helicobacter pylori-induced activation of beta-catenin involves low density lipoprotein receptor-related protein 6 and Dishevelled.	WNT3A LRP6	2.63e-05	5	57	2	20137080
Pubmed	Wnt antagonists bind through a short peptide to the first β-propeller domain of LRP5/6.	WNT3A LRP6	2.63e-05	5	57	2	21944579
Pubmed	A novel set of Wnt-Frizzled fusion proteins identifies receptor components that activate beta -catenin-dependent signaling.	WNT3A LRP6	2.63e-05	5	57	2	12121999
Pubmed	Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis.	WNT3A WNT10A LRP6	3.12e-05	37	57	3	15342465
Pubmed	Tissue-specific requirements of beta-catenin in external genitalia development.	WNT3A WNT10A LRP6	3.38e-05	38	57	3	18635608
Pubmed	N-cadherin interacts with axin and LRP5 to negatively regulate Wnt/beta-catenin signaling, osteoblast function, and bone formation.	WNT3A LRP6	3.94e-05	6	57	2	19075000
Pubmed	Requirement of prorenin receptor and vacuolar H+-ATPase-mediated acidification for Wnt signaling.	WNT3A LRP6	3.94e-05	6	57	2	20093472
Pubmed	Wnt/Lrp/beta-catenin signaling suppresses adipogenesis by inhibiting mutual activation of PPARgamma and C/EBPalpha.	WNT3A LRP6	3.94e-05	6	57	2	17888405
Pubmed	ZDHHC11 Positively Regulates NF-κB Activation by Enhancing TRAF6 Oligomerization.	ZDHHC11B ZDHHC11	3.94e-05	6	57	2	34490261
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	FRAS1 ANKFY1 UBR5 ADAM9 PCDH19 ZMYM3	5.43e-05	407	57	6	12693553
Pubmed	In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes.	ZDHHC11B ZDHHC11	5.51e-05	7	57	2	23687301
Pubmed	Members of the WNT signaling pathways are widely expressed in mouse ovaries, oocytes, and cleavage stage embryos.	WNT3A WNT10A LRP6	6.43e-05	47	57	3	18351675
Pubmed	Wnt antagonist SFRP3 inhibits the differentiation of mouse hepatic progenitor cells.	WNT3A WNT10A LRP6	7.29e-05	49	57	3	19562671
Pubmed	Adamts17 is involved in skeletogenesis through modulation of BMP-Smad1/5/8 pathway.	FBN1 ADAMTS17	7.34e-05	8	57	2	31201465
Pubmed	Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6.	WNT3A LRP6	7.34e-05	8	57	2	20093360
Pubmed	Identification of genetic risk factors for maxillary lateral incisor agenesis.	SPRY4 WNT10A	7.34e-05	8	57	2	24554542
Pubmed	LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6.	WNT3A LRP6	9.43e-05	9	57	2	22899650
Pubmed	Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin.	WNT3A LRP6	9.43e-05	9	57	2	16890161
Pubmed	Transcriptional profiling reveals ductus arteriosus-specific genes that regulate vascular tone.	SLIT2 KCNMA1	9.43e-05	9	57	2	24790087
Pubmed	Mouse cristin/R-spondin family proteins are novel ligands for the Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent gene expression.	WNT3A LRP6	9.43e-05	9	57	2	16543246
Pubmed	Efficient suppression of FGF-2-induced ERK activation by the cooperative interaction among mammalian Sprouty isoforms.	EGF SPRY4	9.43e-05	9	57	2	16339969
Pubmed	An LDL-receptor-related protein mediates Wnt signalling in mice.	WNT3A LRP6	9.43e-05	9	57	2	11029008
Pubmed	Wnt proteins induce dishevelled phosphorylation via an LRP5/6- independent mechanism, irrespective of their ability to stabilize beta-catenin.	WNT3A LRP6	1.18e-04	10	57	2	15143170
Pubmed	Aberrantly activated Wnt/β-catenin pathway co-receptors LRP5 and LRP6 regulate osteoblast differentiation in the developing coronal sutures of an Apert syndrome (Fgfr2S252W/+ ) mouse model.	WNT3A LRP6	1.18e-04	10	57	2	32822074
Pubmed	Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex.	WNT3A LRP6	1.44e-04	11	57	2	18606138
Pubmed	ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner.	WNT3A LRP6	1.44e-04	11	57	2	22575959
Pubmed	LRP2 mediates folate uptake in the developing neural tube.	LRP6 LRP1B	1.44e-04	11	57	2	24639464
Pubmed	The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices.	FRAS1 FBN1 ADAMTS17 COLQ	1.66e-04	167	57	4	22159717
Pubmed	Molecular dynamics of Dkk4 modulates Wnt action and regulates meibomian gland development.	WNT10A LRP6	1.72e-04	12	57	2	27864382
Pubmed	Syndactyly in a novel Fras1(rdf) mutant results from interruption of signals for interdigital apoptosis.	FRAS1 SPRY4	1.72e-04	12	57	2	26813283
Pubmed	The importance of Wnt signalling for neurodegeneration in Parkinson's disease.	WNT3A LRP6	1.72e-04	12	57	2	22988876
Pubmed	Separate and distinctive roles for Wnt5a in tongue, lingual tissue and taste papilla development.	WNT3A WNT10A	2.03e-04	13	57	2	22024319
Pubmed	Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.	FBN1 RASGRP3 NFXL1	2.20e-04	71	57	3	33541421
Pubmed	A mechanism for gene-environment interaction in the etiology of congenital scoliosis.	WNT3A SPRY4	2.37e-04	14	57	2	22484060
Pubmed	Expression patterns of Wnt genes in mouse gut development.	WNT3A WNT10A	2.73e-04	15	57	2	11429295
Pubmed	Expression and estradiol regulation of Wnt genes in the mouse blastocyst identify a candidate pathway for embryo-maternal signaling at implantation.	WNT3A WNT10A	2.73e-04	15	57	2	15044261
Pubmed	Molecular genetic studies of Wnt signaling in the mouse.	WNT3A WNT10A	3.12e-04	16	57	2	10585256
Pubmed	The Wnts.	WNT3A WNT10A	3.12e-04	16	57	2	9889131
Pubmed	Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families.	WNT3A WNT10A	3.53e-04	17	57	2	28733458
Pubmed	Gata3 is required for early morphogenesis and Fgf10 expression during otic development.	WNT3A WNT10A	3.97e-04	18	57	2	16806848
Pubmed	Proteolysis of fibrillin-2 microfibrils is essential for normal skeletal development.	FBN1 ADAMTS17	3.97e-04	18	57	2	35503090
Pubmed	Chromosomal mapping of Adam9, Adam15 and Adam21.	ADAM21 ADAM9	3.97e-04	18	57	2	10842103
Pubmed	Conditional mutations of beta-catenin and APC reveal roles for canonical Wnt signaling in lens differentiation.	WNT3A WNT10A LRP6	4.43e-04	90	57	3	19515997
Pubmed	Coronary Artery Formation Is Driven by Localized Expression of R-spondin3.	WNT3A WNT10A	4.43e-04	19	57	2	28834739
Pubmed	Prenatal lung epithelial cell-specific abrogation of Alk3-bone morphogenetic protein signaling causes neonatal respiratory distress by disrupting distal airway formation.	FBN1 LRP6	4.43e-04	19	57	2	18258849
Pubmed	Identification of a Pax6-dependent epidermal growth factor family signaling source at the lateral edge of the embryonic cerebral cortex.	EGF WNT3A	4.43e-04	19	57	2	12878679
Pubmed	Characterization of Wnt gene expression in developing and postnatal hair follicles and identification of Wnt5a as a target of Sonic hedgehog in hair follicle morphogenesis.	WNT3A WNT10A	4.43e-04	19	57	2	11520664
Pubmed	Regulation of angiogenesis by a non-canonical Wnt-Flt1 pathway in myeloid cells.	WNT3A LRP6	4.43e-04	19	57	2	21623369
Pubmed	A Wnt-bmp feedback circuit controls intertissue signaling dynamics in tooth organogenesis.	WNT3A WNT10A	4.92e-04	20	57	2	22234613
Pubmed	Patterns of Wnt pathway activity in the mouse incisor indicate absence of Wnt/beta-catenin signaling in the epithelial stem cells.	WNT3A WNT10A	5.43e-04	21	57	2	19806668
Pubmed	MESD is essential for apical localization of megalin/LRP2 in the visceral endoderm.	LRP6 LRP1B	5.43e-04	21	57	2	21337463
Pubmed	MT1-MMP inactivates ADAM9 to regulate FGFR2 signaling and calvarial osteogenesis.	ADAM9 SPRY4	5.43e-04	21	57	2	22632802
Pubmed	The WNT7b promoter is regulated by TTF-1, GATA6, and Foxa2 in lung epithelium.	WNT3A WNT10A	5.43e-04	21	57	2	11914369
Pubmed	Epithelial Wnt10a Is Essential for Tooth Root Furcation Morphogenesis.	WNT3A WNT10A	5.43e-04	21	57	2	31914354
Pubmed	Supt20 is required for development of the axial skeleton.	WNT3A SPRY4	5.43e-04	21	57	2	27894818
Pubmed	Evolutionarily conserved requirement of Cdx for post-occipital tissue emergence.	WNT3A SPRY4	5.43e-04	21	57	2	22675207
Pubmed	Characterization of Wnt signaling components and activation of the Wnt canonical pathway in the murine retina.	WNT3A WNT10A	5.97e-04	22	57	2	12815618
Pubmed	Expression of the Wnt inhibitor Dickkopf-1 is required for the induction of neural markers in mouse embryonic stem cells differentiating in response to retinoic acid.	WNT3A LRP6	5.97e-04	22	57	2	17064353
Pubmed	Activation of beta-Catenin in mouse prostate causes HGPIN and continuous prostate growth after castration.	WNT3A WNT10A	5.97e-04	22	57	2	18991257
Pubmed	FGF4 and FGF8 comprise the wavefront activity that controls somitogenesis.	WNT3A SPRY4	6.53e-04	23	57	2	21368122
Pubmed	Does murine spermatogenesis require WNT signalling? A lesson from Gpr177 conditional knockout mouse models.	WNT3A WNT10A	6.53e-04	23	57	2	27362799
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	FRAS1 ADAM9 NFXL1 KMT2A ZNFX1 POLR3A	6.73e-04	650	57	6	38777146
Pubmed	Activation of the Wnt-beta catenin pathway in a cell population on the surface of the forebrain is essential for the establishment of olfactory axon connections.	WNT3A WNT10A	9.02e-04	27	57	2	17804636
Pubmed	Compartment-dependent activities of Wnt3a/β-catenin signaling during vertebrate axial extension.	WNT3A SPRY4	9.02e-04	27	57	2	25152336
Pubmed	Genetic link between renal birth defects and congenital heart disease.	SLIT2 FRAS1	9.71e-04	28	57	2	27002738
Pubmed	Frizzled 1 and frizzled 2 genes function in palate, ventricular septum and neural tube closure: general implications for tissue fusion processes.	WNT3A WNT10A	9.71e-04	28	57	2	20940229
Pubmed	Ectodermal Wnt signaling regulates abdominal myogenesis during ventral body wall development.	WNT3A WNT10A	9.71e-04	28	57	2	24394376
Pubmed	Wnt5a potentiates TGF-β signaling to promote colonic crypt regeneration after tissue injury.	WNT3A WNT10A	1.04e-03	29	57	2	22956684
Pubmed	3D representation of Wnt and Frizzled gene expression patterns in the mouse embryo at embryonic day 11.5 (Ts19).	WNT3A WNT10A	1.04e-03	29	57	2	18364260
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	ANKFY1 NFX1 KMT2A WDFY2 ZMYM3 ZNF445	1.05e-03	709	57	6	22988430
Interaction	LYZL1 interactions	FRAS1 UBR5 ADAM21 ADAM9 LRP6	1.74e-05	118	55	5	int:LYZL1
Interaction	LYPD1 interactions	FRAS1 ADAM21 ADAM9 LRP6	1.89e-05	58	55	4	int:LYPD1
Interaction	NTN5 interactions	FRAS1 FBN1 LRP1B	3.74e-05	24	55	3	int:NTN5
Interaction	GPHA2 interactions	FRAS1 ADAM9 ZMYM3	4.24e-05	25	55	3	int:GPHA2
Interaction	GGH interactions	FRAS1 ANKFY1 ADAM21 ADAM9 LRP6 ZMYM3	5.11e-05	243	55	6	int:GGH
Interaction	IGFL3 interactions	FRAS1 UBR5 ADAM9 LRP1B	5.23e-05	75	55	4	int:IGFL3
Interaction	NMS interactions	FRAS1 LRP6 LRP1B	7.41e-05	30	55	3	int:NMS
Interaction	SIRPD interactions	FRAS1 ADAM21 ADAM9 LRP6	8.93e-05	86	55	4	int:SIRPD
Interaction	DKK1 interactions	RC3H1 WNT3A LRP6	9.02e-05	32	55	3	int:DKK1
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF43 ZNF175 ZNF735 ZNF667 ZNF814 ZNF397 ZNF786 ZNF222 ZNF445	2.11e-05	718	40	9	28
GeneFamily	Zinc fingers FYVE-type\|Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors	ANKFY1 WDFY2 WDFY1	4.32e-05	31	40	3	81
GeneFamily	Low density lipoprotein receptors	LRP6 LRP1B	3.67e-04	13	40	2	634
GeneFamily	Wnt family\|Endogenous ligands	WNT3A WNT10A	7.97e-04	19	40	2	360
GeneFamily	Zinc fingers DHHC-type\|Ankyrin repeat domain containing	ZDHHC11B ZDHHC11	1.28e-03	24	40	2	76
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	ADAM21 ADAM9	1.62e-03	27	40	2	47
GeneFamily	PHD finger proteins	NFX1 KMT2A	1.69e-02	90	40	2	88
Coexpression	NABA_MATRISOME	SLIT2 FRAS1 FBN1 EGF CRIM1 ADAM21 ADAM9 WNT3A ADAMTS17 WNT10A COLQ	6.53e-06	1008	55	11	MM17056
Coexpression	NABA_MATRISOME	SLIT2 FRAS1 FBN1 EGF CRIM1 ADAM21 ADAM9 WNT3A ADAMTS17 WNT10A COLQ	7.72e-06	1026	55	11	M5889
Coexpression	WANG_RESPONSE_TO_BEXAROTENE_UP	EGF CIAPIN1 NFX1	5.00e-05	34	55	3	M1263
Coexpression	NABA_ECM_GLYCOPROTEINS	SLIT2 FRAS1 FBN1 CRIM1 COLQ	5.05e-05	191	55	5	MM17059
Coexpression	NABA_ECM_GLYCOPROTEINS	SLIT2 FRAS1 FBN1 CRIM1 COLQ	5.71e-05	196	55	5	M3008
Coexpression	LAKE_ADULT_KIDNEY_C14_DISTAL_CONVOLUTED_TUBULE	FRAS1 EGF ADAMTS17 LRP1B WDFY2	7.56e-05	208	55	5	M39233
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 EGF ADAMTS17 LRP1B WDFY2 STAC	1.54e-07	189	57	6	975c0f079903ae36b0ffa54e86294d42ec7697de
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ZDHHC11B EGF ADAMTS17 WDFY2 STAC	2.83e-06	173	57	5	4bc6d93716f093b460c8b047199db8cab5fea720
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ZDHHC11B EGF ADAMTS17 WDFY2 STAC	3.52e-06	181	57	5	e0abf2707d9e0aa942c657eef7d2cbcd02f060dd
ToppCell	human_hepatoblastoma-Tumor_cells-T5\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	FRAS1 CRIM1 UBR5 KCNMA1 DGKD	4.24e-06	188	57	5	b070a0667f1ee9b825b267b6c389b7c42fc436f9
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 EGF ADAMTS17 WDFY2 STAC	4.35e-06	189	57	5	7eb8f5a951e80f1cfac4d7c9eb169f4eb100c917
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_adventitial_fibro_(10)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	FRAS1 ADAMTS17 HS6ST3 LRP1B STAC	4.58e-06	191	57	5	156b467187331ac6ca390d6ca861d9670bb7b956
ToppCell	LPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	SLIT2 FBN1 ADAMTS17 LRP6 ITGB8	5.59e-06	199	57	5	8b86c69aaf60feff53aa782559cfece7342a23de
ToppCell	Control_saline-Mesenchymal_myocytic-Pericyte-Pericyte_2\|Control_saline / Treatment groups by lineage, cell group, cell type	SLIT2 CRIM1 SPRY4 LRP6 DGKD	5.73e-06	200	57	5	bc8949eb34482aca166c4602ff6ab876cb4c2c3c
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 EGF ADAMTS17 STAC	3.12e-05	140	57	4	5e81fa3a19d23f0e9cae3878431ca1f78dff7238
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 ZDHHC11B ADAMTS17 STAC	3.30e-05	142	57	4	5b6b0c611c83b23ef7289854a515b78f6cf84500
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS17 KCNMA1 LRP1B CLHC1	5.38e-05	161	57	4	4bb7bae54ba3bdf46b525c01f5ad3db8e49819cb
ToppCell	E16.5-samps-Mesenchymal-Matrix_fibroblast-_fetal-Mature_Fibroblast_1\|E16.5-samps / Age Group, Lineage, Cell class and subclass	SLIT2 FBN1 ADAMTS17 POLR3A	5.65e-05	163	57	4	f1ec2625b52664308968b01d8e0275e1e0751480
ToppCell	wk_15-18-Mesenchymal-Fibroblast-Mesenchymal_3\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	ADAMTS17 HFM1 LRP1B ZMYM3	7.11e-05	173	57	4	b43817a6b1ed8d6b5366702343be4311c0d52d83
ToppCell	PND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_G2M\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CRIM1 PCDH19 ZNF667 DEPDC1	7.44e-05	175	57	4	15c69dd5635c9251c535f1e22467712e9667ae92
ToppCell	facs-Lung-nan-3m-Mesenchymal-Alveolar_Fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLIT2 FBN1 ADAMTS17 COLQ	8.66e-05	182	57	4	dbe4b2557cf19e0682ed446f8397d3a1153642f0
ToppCell	facs-Lung-nan-3m-Mesenchymal-fibroblast_of_lung\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLIT2 FBN1 ADAMTS17 COLQ	8.66e-05	182	57	4	c557de6ccd327c46e0a5423cd9936d78e0abae5f
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	EGF ADAMTS17 LRP1B WDFY2	8.66e-05	182	57	4	041bc819e6cf2618bf86bce8dfe2df673f392ba3
ToppCell	COVID-19-Heart-CM_4\|COVID-19 / Disease (COVID-19 only), tissue and cell type	EGF RASGRP3 DGKD HS6ST3	8.84e-05	183	57	4	2902b6e8aa9a6f62bc1a792c971ab7f651a8e676
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	EGF ADAMTS17 LRP1B WDFY2	8.84e-05	183	57	4	31ab55d5f3639f5964541d5eae23044dbda3356e
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SLIT2 CRIM1 SPRY4 DGKD	8.84e-05	183	57	4	8a799807fbf24456a9811e0c64068187940a2f71
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 EGF WDFY2 STAC	8.84e-05	183	57	4	2e831a4d99c6f983793df71c0994124c943c6da9
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	EGF ADAMTS17 LRP1B WDFY2	9.22e-05	185	57	4	898a093757f86be3e18d2ef1f16a71f50ef81dc3
ToppCell	droplet-Lung-30m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l49\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SLIT2 FBN1 ADAMTS17 COLQ	9.22e-05	185	57	4	355b03c7ea438681e11a2b872c798c9ea26e1486
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SLIT2 CRIM1 KCNMA1 STAC	9.41e-05	186	57	4	4780af76237d7af2abbe2d8d5530cdf53e3ed0b7
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	EGF ADAMTS17 LRP1B WDFY2	9.61e-05	187	57	4	b93cf4dfe8ffb89348ee7bccc9f284189f7240a2
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	EGF ADAMTS17 LRP1B WDFY2	9.61e-05	187	57	4	7ea8731288e2a99f45e3958590ee1d76f49ae888
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	KCNMA1 WNT10A LRP1B STAC	9.61e-05	187	57	4	87b3d0478693d4c54ff06b74e5903036b9c1ee6a
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	KCNMA1 WNT10A LRP1B STAC	9.61e-05	187	57	4	42a1267bfc27b4460b8409ada580a87c4385841c
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	KCNMA1 WNT10A LRP1B STAC	9.61e-05	187	57	4	64afdea159f5e67a1e5cea35ce898aae6e80aea5
ToppCell	Control-Fibroblasts-Alveolar_FB\|Control / group, cell type (main and fine annotations)	SLIT2 FRAS1 FBN1 ADAMTS17	9.61e-05	187	57	4	92d468dde81125d51daf7abd4703741abe1ab91c
ToppCell	-Unknown-Endothelial-Myofibroblast\| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SNX14 UBR5 KCNMA1 KMT2A	9.81e-05	188	57	4	6468fa95ad0395395301115286f2d8c0df5d3882
ToppCell	-Unknown-Endothelial\| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SNX14 UBR5 KCNMA1 KMT2A	9.81e-05	188	57	4	7a81ac5c79c3eb26639b52d2b9fd5e7ef9798fd6
ToppCell	-Unknown\| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SNX14 UBR5 KCNMA1 KMT2A	9.81e-05	188	57	4	9cb718bfe1358c6fd842f096e228eb0abb9aefc6
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	EGF ADAMTS17 LRP1B WDFY2	9.81e-05	188	57	4	3cee9916399e2e7580cecbcbb27424a71e7e7ac0
ToppCell	COVID-19-kidney-DCT\|kidney / Disease (COVID-19 only), tissue and cell type	EGF ADAMTS17 LRP1B STAC	9.81e-05	188	57	4	df1fd0819d301679f3c9ea404e942e39095912eb
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	EGF ADAMTS17 LRP1B WDFY2	1.00e-04	189	57	4	f51cdc9a47371cab8ed9ae63a6f14da07ede446c
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	EGF ADAMTS17 KCNMA1 LRP1B	1.00e-04	189	57	4	e32172ad09e93f6ac6ea2b92145b2b73003f7970
ToppCell	droplet-Lung-LUNG-1m-Mesenchymal-fibroblast_of_lung\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLIT2 FBN1 ADAMTS17 COLQ	1.00e-04	189	57	4	32e6d6285b258831b965281224ff2aaeecdcb5f5
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	EGF ADAMTS17 WDFY2 STAC	1.00e-04	189	57	4	977a813e5d7a5a561c1fced2bbf21c20056b88d8
ToppCell	droplet-Lung-LUNG-1m-Mesenchymal-Alveolar_Fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLIT2 FBN1 ADAMTS17 COLQ	1.00e-04	189	57	4	385ef7bbd76c8047aeecf6542377d4213b5da5db
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLIT2 ADAMTS17 HS6ST3 STAC	1.02e-04	190	57	4	1bbbf0ce222e51f9fd2daca0c18d3965fd4efd31
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	EGF ADAMTS17 LRP1B WDFY2	1.02e-04	190	57	4	b94df372bc08de11585b2467dba8c8fffff5cd92
ToppCell	COVID-19-Heart-CM_4\|Heart / Disease (COVID-19 only), tissue and cell type	EGF RASGRP3 DGKD HS6ST3	1.02e-04	190	57	4	3729648a17093b438398b82e32bbccc3af7b8c5d
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	EGF ADAMTS17 LRP1B WDFY2	1.02e-04	190	57	4	cc17ab84a9328124f146951c06be3eff9650d9fd
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	EGF ADAMTS17 WDFY2 STAC	1.02e-04	190	57	4	e252e925600e6457fa6e362a55217f4cffa75cdb
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-AF1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SLIT2 FRAS1 FBN1 ADAMTS17	1.04e-04	191	57	4	6688cee34beee4f151ac17fccbc9c26a9aad72e1
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SLIT2 FRAS1 FBN1 ADAMTS17	1.06e-04	192	57	4	99ce9e3c4c50cf64ebb62145f2b5420efa0db309
ToppCell	LPS_only-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SLIT2 FBN1 ADAMTS17 ITGB8	1.06e-04	192	57	4	df1545670370fb1010c567cd059c2783eab315f7
ToppCell	PND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SLIT2 FBN1 ADAMTS17 COLQ	1.09e-04	193	57	4	4c74a3f69b2cbdf139e7e66b44bd86869ac34dc0
ToppCell	facs-Lung-EPCAM-3m-Mesenchymal-fibroblast_of_lung\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLIT2 ADAMTS17 COLQ HS6ST3	1.09e-04	193	57	4	027e098ad018e782287f84eee0f77551018f2196
ToppCell	PND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SLIT2 FBN1 ADAMTS17 COLQ	1.09e-04	193	57	4	ff8ceeb3cfd1bef7239df490c19d181091750833
ToppCell	facs-Lung-EPCAM-3m-Mesenchymal-Alveolar_Fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLIT2 ADAMTS17 COLQ HS6ST3	1.09e-04	193	57	4	c5463a87f20b3a7f7ffda677b2f5a0e9e49d6685
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia_independent-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FBN1 CRIM1 ADAM9 ITGB8	1.11e-04	194	57	4	f44394c8a6f86483063f2f5722f003a8a0a70254
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 EGF LRP1B ITGB8	1.13e-04	195	57	4	6477e6e7be5bd8eb99119a12ae16334ccddecd43
ToppCell	COVID-19-Fibroblasts-Alveolar_FB\|COVID-19 / group, cell type (main and fine annotations)	SLIT2 FRAS1 FBN1 ADAMTS17	1.13e-04	195	57	4	603050beeb33c331d4b2e3fa46cae3f3e0e4bdc7
ToppCell	Parenchymal-NucSeq-Immune_Myeloid-Macrophage_alveolar-Macro_alv_dividing\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	KCNMA1 DEPDC1 ITGB8 STAC	1.17e-04	197	57	4	d669d90c3f9e98b41bcbc49dbdc5698e0b42597c
ToppCell	Tracheal-10x5prime-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	KCNMA1 HFM1 COLQ HS6ST3	1.20e-04	198	57	4	1e1ea54f0c234f3b6d29064c4881d8a0c0949a75
ToppCell	Bronchial-NucSeq-Immune_Myeloid-Macrophage_other-Macro_CHIT1\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	RASGRP3 KCNMA1 ASIC5 STAC	1.20e-04	198	57	4	0b41b3d6c2db795320e8b65d40d85fb8b618cc34
ToppCell	Control_saline-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB\|Control_saline / Treatment groups by lineage, cell group, cell type	SLIT2 ADAM9 PCDH19 ITGB8	1.20e-04	198	57	4	0c4d2c68a42f8a9e964e2dd28092fe75f5216834
ToppCell	Tracheal\|World / Cell types per location group and 10X technology with lineage, and cell group designations	EGF ADAMTS17 KCNMA1 ITGB8	1.24e-04	200	57	4	682960e28542a3d6c119047cd0131941932cfdea
ToppCell	LPS_anti-TNF-Mesenchymal_myocytic-Pericyte\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	SLIT2 CRIM1 SPRY4 DGKD	1.24e-04	200	57	4	4e1e19214aeebbdca004de7faaf4cc9d18498591
ToppCell	LPS_IL1RA-Mesenchymal_myocytic-Pericyte-Pericyte_2\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	SLIT2 CRIM1 SPRY4 LRP6	1.24e-04	200	57	4	cf883ba5dbe6350b93142d625a52b25ff2a8bb63
ToppCell	Parenchymal-NucSeq-Stromal-Fibroblastic-Fibro_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SLIT2 FRAS1 FBN1 ADAMTS17	1.24e-04	200	57	4	34f52003988ce6329d8deeee1ab875fa77e01e9d
Disease	Weill-Marchesani syndrome (implicated_via_orthology)	FBN1 ADAMTS17	1.02e-05	3	55	2	DOID:0050475 (implicated_via_orthology)
Disease	Weill-Marchesani syndrome	FBN1 ADAMTS17	2.04e-05	4	55	2	cv:C0265313
Disease	Weill-Marchesani syndrome (is_implicated_in)	FBN1 ADAMTS17	2.04e-05	4	55	2	DOID:0050475 (is_implicated_in)
Disease	hair morphology	FRAS1 EGF WNT10A	2.16e-05	29	55	3	EFO_0005038
Disease	obesity	TNNI3K KCNMA1 DGKD HS6ST3 STAC	8.69e-05	241	55	5	EFO_0001073
Disease	lung adenocarcinoma (is_implicated_in)	EGF UBR5 LRP1B	1.06e-04	49	55	3	DOID:3910 (is_implicated_in)
Disease	tooth agenesis (is_implicated_in)	WNT10A LRP6	1.52e-04	10	55	2	DOID:0050591 (is_implicated_in)
Disease	motor function measurement	ADAM21 ADAMTS17	1.86e-04	11	55	2	EFO_0010749
Disease	Oligodontia	WNT10A LRP6	2.22e-04	12	55	2	C4082304
Disease	gallbladder cancer (is_implicated_in)	EGF LRP1B	2.63e-04	13	55	2	DOID:3121 (is_implicated_in)
Disease	central corneal thickness	FBN1 CRIM1 ADAMTS17 WNT10A KMT2A	2.76e-04	309	55	5	EFO_0005213
Disease	Hypodontia	WNT10A LRP6	3.06e-04	14	55	2	C0020608
Disease	Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse	UBR5 WNT10A	4.03e-04	16	55	2	C0334634
Disease	Prostatic Neoplasms	RLN2 EGF ADAM9 KMT2A LRP1B ZMYM3	9.83e-04	616	55	6	C0033578
Disease	Malignant neoplasm of prostate	RLN2 EGF ADAM9 KMT2A LRP1B ZMYM3	9.83e-04	616	55	6	C0376358
Disease	Mental Retardation, X-Linked	PCDH19 ZMYM3	1.34e-03	29	55	2	C1136249
Disease	corneal resistance factor	FBN1 ADAMTS17 WNT10A LRP6 KMT2A	1.51e-03	451	55	5	EFO_0010067

Protein segments in the cluster

Peptide	Gene	Start	Entry
TVCGPGKICIHKKCV	ADAM21	611	Q9UKJ8
KKRKACKNCTCGLAE	CIAPIN1	241	Q6FI81
CVHGKCQKIGCDGII	ADAMTS17	666	Q8TE56
LGCGHTVCKMCLNKL	RC3H1	31	Q5TC82
ALANKCCHVGCTKRS	RLN2	166	P04090
CRHCGRLLCHKCSTK	ANKFY1	1126	Q9P2R3
GCFIKGQNSKCLHCI	PCDH19	726	Q8TAB3
DQKKRGGHKACCLLT	COLQ	41	Q9Y215
CHKQACLPLRCGKGQ	FRAS1	251	Q86XX4
KCPLNHIACLGTNKC	LRP1B	76	Q9NZR2
TVCCHCGGKTKEAQK	KCNMA1	116	Q12791
EKHCRCGKHTKRMPC	NFXL1	446	Q6ZNB6
CRLKCHNKCTKEAPA	KSR1	376	Q8IVT5
ELCNGKCKSKQLCRS	DEPDC1	496	Q5TB30
SCLKICGKDLKCGNH	NFX1	556	Q12986
FRCANGQCIGKHKKC	LRP6	1331	O75581
SCKAGQKKCTCHRPG	HS6ST3	176	Q8IZP7
LCKSKHTCGHDCCKI	HFM1	1146	A2PYH4
CVCGKCSCHKIKLGK	ITGB8	526	P26012
KLCKLRKGNCSSTVC	EGF	316	P01133
HGKCRNTIGSFKCRC	FBN1	1041	P35555
GLLKNKHGCDICRCK	CRIM1	551	Q9NZV1
KHGCDICRCKKCPEL	CRIM1	556	Q9NZV1
KKCATGNALCGKLQC	ADAM9	561	Q13443
LKECKAQHIKKQCGC	ASIC5	316	Q9NY37
GLSCEVCKFKAHKRC	DGKD	191	Q16760
ASNKLPCNCGAKKCR	KMT2A	3951	Q03164
PGCRCKHTNSVICKA	SPRY4	271	Q9C004
KDCGANCHKQCKDLL	RASGRP3	526	Q8IV61
ISDKCRKKNICHHCG	POLR3A	146	O14802
GLHKKAILCLCKQGQ	CLHC1	431	Q8NHS4
NTRCEKCQKGVHAKC	PGBD2	571	Q6P3X8
IHVVGNVCQCRKCGK	ZNF667	246	Q5HYK9
GKCGHENLQLKKCCK	ZNF735	116	P0CB33
KIGLRQHHCRKCGKA	WDFY2	306	Q96P53
QHHCRKCGKAVCGKC	WDFY2	311	Q96P53
CRKGIVCNLCGKRGH	ZCCHC3	366	Q9NUD5
PQGHSCAVCGKVKCK	SNX14	96	Q9Y5W7
CAVCGKVKCKRHRPS	SNX14	101	Q9Y5W7
GLRCKACKMSIHHKC	STAC	136	Q99469
HGVGKLCKCNDCHKV	ZNF137P	66	P52743
CQAIKCKHGKCRLSG	SLIT2	1416	O94813
QNRCVHSQCKKKCGE	ZNFX1	1491	Q9P2E3
HSQCKKKCGELCSPC	ZNFX1	1496	Q9P2E3
KKTKHCISCNKCVSG	ZDHHC11	136	Q9H8X9
HTRVNFCKCEKCGKA	ZNF43	196	P17038
SCRKCGKGFAKQCKL	ZNF786	426	Q8N393
ISIGKKCHKCSICGK	ZNF445	971	P59923
KIHTGEKACKCNECG	ZNF397	361	Q8NF99
LKCKCHGLSGSCEVK	WNT3A	201	P56704
SCGGHCKKGKCESHQ	TYW1	251	Q9NV66
KCKCHGTSGSCQLKT	WNT10A	261	Q9GZT5
KKTKHCISCNKCVSG	ZDHHC11B	136	P0C7U3
LHLCCICGGKKSHIR	TNNI3K	71	Q59H18
KCGQAVCGKCSSKRS	WDFY1	316	Q8IWB7
KAARCHACKRQGKLL	ZMYM3	716	Q14202
KCGECGKCFSHKGNL	ZNF814	661	B7Z6K7
FCKGNQCRKVCGHKQ	ZNF175	251	Q9Y473
CGKGFRCRSALKVHC	ZNF222	206	Q9UK12
HCQRKPLKCEDCGKR	ZNF222	391	Q9UK12
CARVCHKGHDCKLKR	UBR5	1211	O95071
GKCGHENLQFKKCCK	ZNF722	116	A0A1W2PQL4