Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	IQ	MYO9A SCN1A UBE3B IQGAP3	7.45e-05	71	59	4	PF00612
Domain	IQ	MYO9A SCN1A UBE3B IQGAP3	1.25e-04	81	59	4	SM00015
Domain	IQ_motif_EF-hand-BS	MYO9A SCN1A UBE3B IQGAP3	1.87e-04	90	59	4	IPR000048
Domain	IQ	MYO9A SCN1A UBE3B IQGAP3	2.13e-04	93	59	4	PS50096
Domain	6-hairpin_glycosidase-like	MOGS RENBP	7.48e-04	13	59	2	IPR008928
Domain	Dynein_heavy_chain_D4_dom	DNAH10 DNAH1	8.71e-04	14	59	2	IPR024317
Domain	Dynein_HC_stalk	DNAH10 DNAH1	8.71e-04	14	59	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH10 DNAH1	8.71e-04	14	59	2	IPR013602
Domain	DHC_N2	DNAH10 DNAH1	8.71e-04	14	59	2	PF08393
Domain	MT	DNAH10 DNAH1	8.71e-04	14	59	2	PF12777
Domain	AAA_8	DNAH10 DNAH1	8.71e-04	14	59	2	PF12780
Domain	ATPase_dyneun-rel_AAA	DNAH10 DNAH1	8.71e-04	14	59	2	IPR011704
Domain	AAA_5	DNAH10 DNAH1	8.71e-04	14	59	2	PF07728
Domain	DHC_fam	DNAH10 DNAH1	1.00e-03	15	59	2	IPR026983
Domain	Dynein_heavy_dom	DNAH10 DNAH1	1.00e-03	15	59	2	IPR004273
Domain	Dynein_heavy	DNAH10 DNAH1	1.00e-03	15	59	2	PF03028
Domain	F-box	FBXL12 FBXW4 FBXO47	1.24e-03	67	59	3	PF00646
Domain	FBOX	FBXL12 FBXW4 FBXO47	1.53e-03	72	59	3	PS50181
Domain	F-box_dom	FBXL12 FBXW4 FBXO47	1.72e-03	75	59	3	IPR001810
Domain	ASX_HYDROXYL	CLEC14A VCAN CUBN	3.90e-03	100	59	3	PS00010
Domain	EGF-type_Asp/Asn_hydroxyl_site	CLEC14A VCAN CUBN	4.59e-03	106	59	3	IPR000152
Domain	P-loop_NTPase	MYO1G BRIP1 DNAH10 MYO9A ARL11 NOA1 SPEF2 DNAH1	4.98e-03	848	59	8	IPR027417
Domain	Myosin_head_motor_dom	MYO1G MYO9A	6.41e-03	38	59	2	IPR001609
Domain	MYOSIN_MOTOR	MYO1G MYO9A	6.41e-03	38	59	2	PS51456
Domain	Myosin_head	MYO1G MYO9A	6.41e-03	38	59	2	PF00063
Domain	MYSc	MYO1G MYO9A	6.41e-03	38	59	2	SM00242
Domain	-	MKRN3 UNK	7.08e-03	40	59	2	4.10.1000.10
Domain	F-box-like	FBXL12 FBXW4	8.52e-03	44	59	2	PF12937
Domain	MFS_dom	SLC49A3 SLC15A3 SLC2A11	8.76e-03	134	59	3	IPR020846
Domain	ZnF_C3H1	MKRN3 UNK	1.01e-02	48	59	2	SM00356
Domain	zf-CCCH	MKRN3 UNK	1.05e-02	49	59	2	PF00642
Domain	FBOX	FBXL12 FBXW4	1.18e-02	52	59	2	SM00256
Pathway	REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION	KLHL2 UBE3B ANAPC2 FBXL12 FBXW4 TRIM37	1.16e-04	299	37	6	MM15711
Pathway	REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION	KLHL2 UBE3B ANAPC2 FBXL12 FBXW4 TRIM37	1.36e-04	308	37	6	M1070
Pathway	REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION	KLHL2 UBE3B ANAPC2 FBXL12 FBXW4 TRIM37	2.44e-04	343	37	6	MM15712
Pathway	REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION	KLHL2 UBE3B ANAPC2 FBXL12 FBXW4 TRIM37	4.28e-04	381	37	6	M1066
Pubmed	Galnt11 regulates kidney function by glycosylating the endocytosis receptor megalin to modulate ligand binding.	GALNT15 RENBP CUBN	1.12e-05	24	63	3	31740596
Pubmed	Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.	IRS4 MYO9A SPEF2 IQGAP3 DOP1A	3.87e-05	208	63	5	33230847
Pubmed	FIGNL1-containing protein complex is required for efficient homologous recombination repair.	SWI5 SPIDR	8.98e-05	8	63	2	23754376
Pubmed	Fully functional hair follicle regeneration through the rearrangement of stem cells and their niches.	VCAN WNT10B	1.76e-04	11	63	2	22510689
Pubmed	Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.	PIEZO2 MYO9A CLEC14A	2.28e-04	65	63	3	23319000
Pubmed	Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.	DNAH10 DNAH1	2.90e-04	14	63	2	9373155
Pubmed	Molecular genetics of hereditary spinocerebellar ataxia: mutation analysis of spinocerebellar ataxia genes and CAG/CTG repeat expansion detection in 225 Italian families.	PLEKHG4 TMEM240	4.32e-04	17	63	2	15148151
Pubmed	Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach.	IRS4 MOGS MYO9A IQGAP3	5.93e-04	211	63	4	17314511
Pubmed	CRISPR/Cas9-mediated Genomic Editing of Cluap1/IFT38 Reveals a New Role in Actin Arrangement.	IRS4 MOGS OGFR IQGAP3	6.14e-04	213	63	4	29615496
Pubmed	Therapeutic targeting of the USP2-E2F4 axis inhibits autophagic machinery essential for zinc homeostasis in cancer progression.	MYO1G NOP9 MOGS OGFR NDUFB9	8.25e-04	403	63	5	35253629
Pubmed	Interactome mapping suggests new mechanistic details underlying Alzheimer's disease.	SCN1A FBXL12 FBXW4	1.09e-03	111	63	3	21163940
Pubmed	Mast cell maturation is driven via a group III phospholipase A2-prostaglandin D2-DP1 receptor paracrine axis.	PLA2G3 LTB4R2	1.10e-03	27	63	2	23624557
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	NOP9 MOGS NOA1 UBE3B ANAPC2 IQGAP3	1.15e-03	650	63	6	38777146
Pubmed	Lipid-orchestrated paracrine circuit coordinates mast cell maturation and anaphylaxis through functional interaction with fibroblasts.	PLA2G3 LTB4R2	1.64e-03	33	63	2	39002541
GeneFamily	Dyneins, axonemal	DNAH10 DNAH1	5.44e-04	17	37	2	536
Coexpression	GSE27786_CD4_TCELL_VS_ERYTHTROBLAST_DN	GALNT15 AJM1 VCAN FBXW4 OOEP SPIDR	8.66e-06	200	63	6	M4828
ToppCell	facs-Lung-18m-Hematologic-myeloid-classical_monocyte\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MYO1G ARL11 VCAN SLC49A3 OTULINL	4.03e-06	168	63	5	0ffad93ba2fb5d4cfda2c13011059555475dcfc8
ToppCell	facs-Lung-18m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l2\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MYO1G ARL11 VCAN SLC49A3 OTULINL	4.03e-06	168	63	5	ab1fb9b2cc7c5853b7fbd373e1784a9a31f96d38
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_low-phase\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	BRIP1 DNAH10 VNN2 CSKMT IQGAP3	4.65e-06	173	63	5	506efcaa5afd6ed5e565c4c4def6a4505fea97c5
Drug	3-methoxy-2-propylbenzaldehyde	NOP9 LTB4R2	2.18e-05	3	62	2	CID013942164
Drug	12-Me-LTB3	NOP9 LTB4R2	2.18e-05	3	62	2	CID006443674
Drug	Q2 36	NOP9 LTB4R2	2.18e-05	3	62	2	CID000161236
Drug	myristyl acetate	NOP9 LTB4R2 CUBN TRIM37	2.63e-05	63	62	4	CID000012531
Drug	LY-306669	NOP9 LTB4R2	4.36e-05	4	62	2	CID003083459
Drug	SC-50605	NOP9 LTB4R2	4.36e-05	4	62	2	CID000204055
Drug	5-aminoindole	NOP9 LTB4R2	4.36e-05	4	62	2	CID000078867
Drug	palladium nitrate	VCAN TRIM37	4.36e-05	4	62	2	CID000024932
Disease	language impairment	NOP9 LTB4R2	2.21e-04	11	60	2	EFO_0005425
Disease	MHPG measurement, 5-HIAA measurement	PIEZO2 CLEC14A	5.42e-04	17	60	2	EFO_0005132, EFO_0005133
Disease	Autism Spectrum Disorders	SCN1A IQGAP3 DNMT3B	7.01e-04	85	60	3	C1510586
Disease	maximal midexpiratory flow rate	GALNT15 BRIP1	7.55e-04	20	60	2	EFO_0004313
Disease	level of Sphingomyelin (d38:1) in blood serum	FBXW4 GLTPD2	1.71e-03	30	60	2	OBA_2045180

Protein segments in the cluster

Peptide	Gene	Start	Entry
AAQRCHEDWKRLARV	CHRNA10	411	Q9GZZ6
EAGNTLRRWRCHVQR	ANAPC2	316	Q9UJX6
HRRTWDAAERECRLQ	VCAN	3186	P13611
RCHGVLRRRKDWNVR	DNMT3B	531	Q9UBC3
RLCRREDWDAHKARC	AJM1	696	C9J069
WFEECCRRTLHVRLQ	DOP1A	441	Q5JWR5
RNRLSLERFQDHCWE	ARL11	136	Q969Q4
RVVLVLRERWHFCRD	FASTK	476	Q14296
LRERWHFCRDGRVLL	FASTK	481	Q14296
LGDWCARRILQHVQR	RENBP	216	P51606
RFLQCSRRQWGRHDC	PRSS12	461	P56730
WAALRSNLRTVACHR	NOP9	126	Q86U38
LHRALRWSQLCLHRV	GLTPD2	186	A6NH11
LQRRLGCRTFHWFLA	GALNT15	476	Q8N3T1
QLWCHASERERRRRL	PNMA6F	281	A0A0J9YX94
ADRCLWDRLHAQPRL	CSKMT	31	A8MUP2
AQLPREQRHRWCLLF	MEAK7	256	Q6P9B6
ARMWAARRQYLRRLH	IQGAP3	801	Q86VI3
LFWRHHIKCVRQVRR	OTULINL	121	Q9NUU6
RHLDLRCWVALGARV	MOGS	596	Q13724
RCIRHRNDWGALILV	BRIP1	831	Q9BX63
LCLAWFHREHRARAE	OOEP	111	A6NGQ2
CSWVIRVDRNHRVLL	CUBN	1536	O60494
RLWYHENCRVFRDRL	DNAH1	2466	Q9P2D7
RCRKELEHREAAWRR	CROCC	266	Q5TZA2
CRARRPWELFQHRAL	SLC2A11	256	Q9BYW1
VRLWDRRQRACLHAF	FBXW4	361	P57775
VCLKLWRHEAARRHR	MARVELD2	361	Q8N4S9
RLFCRNVLLDHWTHR	FBXO47	216	Q5MNV8
VRVWRNECLRVFHDR	DNAH10	2681	Q8IVF4
LWQRHSARDRQCARV	SLC15A3	276	Q8IY34
RTVCQRCWLLSHHRR	NOA1	176	Q8NC60
RCWLLSHHRRALRLQ	NOA1	181	Q8NC60
WLRRSRFEQFCHLRA	IRS4	371	O14654
VRCRHQRRQLVHFAW	OGFR	261	Q9NZT2
HQRVNDLRDRLWDIC	SPEF2	1106	Q9C093
RRWLTEQRAQCPHCR	TRIM37	41	O94972
RAWLRCALNEHSLER	SNX29	116	Q8TEQ0
RDCAHRSWPRLDRLS	TMEM200B	276	Q69YZ2
AAVYRHLWRDRVCQL	LTB4R2	156	Q9NPC1
CHQAWLDFRRRLEAL	PLEKHG4	326	Q58EX7
KRALRHLESWCVQRD	NDUFB9	21	Q9Y6M9
RISRVCHRWKRLVDD	FBXL12	26	Q9NXK8
GARWVCRSFRRHLDQ	PLA2G3	356	Q9NZ20
NLRRTCFRIVEHNWF	SCN1A	1206	P35498
LFWVALERRRSHCTL	CLEC14A	91	Q86T13
ALCAQRGHRTYARRW	SLC49A3	16	Q6UXD7
QRDLWRHNKSCARNR	SWI5	6	Q1ZZU3
LHCAVRAWRAGRRYD	TMEM240	111	Q5SV17
HGRRRREYWQVCTLL	VNN2	391	O95498
NHSFCIRCIRRWRSA	MKRN3	336	Q13064
NRERSAISLWRHQCI	SPIDR	271	Q14159
CWVVVRLDGRNFHRF	THG1L	51	Q9NWX6
VVERDVCHRCRHKRW	RELL1	186	Q8IUW5
HACWLIAVLYRRRRK	PIEZO2	1146	Q9H5I5
QVSLWLRRREHRCGA	TMPRSS9	841	Q7Z410
CRRRFTPEDHWLRKD	UBE3B	606	Q7Z3V4
ADRGHARRCWLRALQ	VWA5B2	911	Q8N398
LRQTRVERCHCRFHW	WNT10B	356	O00744
CFHWHFVNQRRRRSI	UNK	61	Q9C0B0
REALSRLRELCHQWL	ZSCAN12	61	O43309
LWVRFQAVRGLCTRH	WDR81	796	Q562E7
ERWHQVAELPSRRCR	KLHL2	331	O95198
DTCHALFCRWRARQL	MYO1G	786	B0I1T2
LQRWFRVLLCRQHFL	MYO9A	1026	B2RTY4