Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionenzyme activator activity

ARL1 ERCC5 PLCB1 ALS2 RP2 MAP3K13 MAP3K12 RGS2

2.06e-04656508GO:0008047
GeneOntologyMolecularFunctionJUN kinase kinase kinase activity

MAP3K13 MAP3K12

3.99e-0412502GO:0004706
GeneOntologyMolecularFunctionribonucleoside triphosphate phosphatase activity

ARL1 ABCA2 DRG2 NAV2 BTAF1 RAD54L2 RAB3B RGS2

6.28e-04775508GO:0017111
GeneOntologyMolecularFunctionprotein serine/threonine kinase activator activity

ALS2 MAP3K13 MAP3K12

9.85e-0478503GO:0043539
GeneOntologyMolecularFunctionpyrophosphatase activity

ARL1 ABCA2 DRG2 NAV2 BTAF1 RAD54L2 RAB3B RGS2

1.05e-03839508GO:0016462
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides

ARL1 ABCA2 DRG2 NAV2 BTAF1 RAD54L2 RAB3B RGS2

1.06e-03840508GO:0016817
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

ARL1 ABCA2 DRG2 NAV2 BTAF1 RAD54L2 RAB3B RGS2

1.06e-03840508GO:0016818
GeneOntologyBiologicalProcesslateral mesoderm morphogenesis

BMPR1A TAF10 TBX20

1.34e-075503GO:0048369
GeneOntologyBiologicalProcesslateral mesoderm formation

BMPR1A TAF10 TBX20

1.34e-075503GO:0048370
GeneOntologyBiologicalProcesslateral mesoderm development

BMPR1A TAF10 TBX20

1.48e-0520503GO:0048368
GeneOntologyBiologicalProcesslateral mesodermal cell differentiation

BMPR1A TAF10

3.44e-054502GO:0048371
DomainMAP3K12_MAP3K13

MAP3K13 MAP3K12

7.31e-062512IPR017419
DomainAT_hook

ASH1L BOD1L1

2.46e-0327512SM00384
DomainAT_hook_DNA-bd_motif

ASH1L BOD1L1

2.46e-0327512IPR017956
DomainSNF2_N

BTAF1 RAD54L2

3.44e-0332512IPR000330
DomainSNF2_N

BTAF1 RAD54L2

3.44e-0332512PF00176
Domain-

ARL1 ABCA2 DRG2 NAV2 BTAF1 RAD54L2 RAB3B

3.95e-037465173.40.50.300
DomainBROMODOMAIN_1

BAZ2B ASH1L

4.58e-0337512PS00633
DomainBromodomain

BAZ2B ASH1L

4.83e-0338512PF00439
DomainPkinase_Tyr

BMPR1A MAP3K13 MAP3K12

5.26e-03129513PF07714
DomainBROMODOMAIN_2

BAZ2B ASH1L

5.60e-0341512PS50014
DomainBROMO

BAZ2B ASH1L

5.87e-0342512SM00297
DomainBromodomain

BAZ2B ASH1L

5.87e-0342512IPR001487
Domain-

BAZ2B ASH1L

5.87e-03425121.20.920.10
DomainSer-Thr/Tyr_kinase_cat_dom

BMPR1A MAP3K13 MAP3K12

6.34e-03138513IPR001245
DomainP-loop_NTPase

ARL1 ABCA2 DRG2 NAV2 BTAF1 RAD54L2 RAB3B

7.87e-03848517IPR027417
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

CYLC1 PHEX BMPR1A ERCC5 MAP1B CBX5 ASH1L NAV2 BOD1L1 APOB FNBP1L RAD54L2 RAB3B

1.42e-071442521335575683
Pubmed

Molecular cloning and functional expression of a cDNA encoding a new member of mixed lineage protein kinase from human brain.

MAP3K13 MAP3K12

2.19e-0625229353328
Pubmed

Leucine Zipper-bearing Kinase promotes axon growth in mammalian central nervous system neurons.

MAP3K13 MAP3K12

2.19e-06252227511108
Pubmed

Impaired regenerative response of primary sensory neurons in ZPK/DLK gene-trap mice.

MAP3K13 MAP3K12

2.19e-06252219358824
Pubmed

Regulator of G-protein signaling 2 (RGS2) suppresses premature calcium release in mouse eggs.

ZP2 RGS2

6.57e-06352226160904
Pubmed

A Critical Role for DLK and LZK in Axonal Repair in the Mammalian Spinal Cord.

MAP3K13 MAP3K12

6.57e-06352235361703
Pubmed

Activation of MAP3K DLK and LZK in Purkinje cells causes rapid and slow degeneration depending on signaling strength.

MAP3K13 MAP3K12

1.31e-05452233475086
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

BMPR1A ERCC5 CBX5 ASH1L ALS2 BOD1L1 APOB RP2 THOC2

2.96e-05108452911544199
Pubmed

The cell proliferation antigen Ki-67 organises heterochromatin.

ARL1 DRG2 MAP1B NFIC TAF10 SHOC2

3.33e-0541052626949251
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

MAP1B NFIC TRPS1 ASH1L OS9 BOD1L1 BTAF1 FNBP1L HSD11B2 MAP3K12

6.14e-051489521028611215
Pubmed

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.

NRAP ZNF592 CBX5 OS9 CMYA5 AGTPBP1

9.64e-0549752623414517
Pubmed

Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo.

TRPS1 NAV2 OS9 ALS2 ZP2

1.27e-0432652517015433
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

ABCA2 ZNF592 NAV2 PLCB1 SHOC2 GPR107

1.35e-0452952614621295
Pubmed

Enhanced Functional Genomic Screening Identifies Novel Mediators of Dual Leucine Zipper Kinase-Dependent Injury Signaling in Neurons.

MAP3K13 MAP3K12

1.43e-041252228641113
Pubmed

Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.

DRG2 NFIC TRPS1 BTAF1 DERA

1.57e-0434152532971831
Pubmed

The environmental and genetic evidence for the association of hyperlipidemia and hypertension.

APOB RGS2

1.69e-041352219155782
Pubmed

The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.

CARMIL2 NAV2 PLCB1 APOB RP2 GPR107

2.01e-0456952630639242
Pubmed

MAP3Ks as central regulators of cell fate during development.

MAP3K13 MAP3K12

2.27e-041552218855897
Pubmed

The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.

ZNF592 CBX5 NFIC TRPS1 RAD54L2 THOC2

2.29e-0458352629844126
Pubmed

Mutations in the carboxy-terminal domain of TBP affect the synthesis of human immunodeficiency virus type 1 full-length and short transcripts similarly.

BTAF1 TAF10

2.60e-04165228764009
Pubmed

Direct interaction of human TFIID with the HIV-1 transactivator tat.

BTAF1 TAF10

2.60e-04165228121496
Pubmed

Identification of FGF10 targets in the embryonic lung epithelium during bud morphogenesis.

BMPR1A TMEM123

2.60e-041652215556938
Pubmed

Wild-type and transactivation-defective mutants of human immunodeficiency virus type 1 Tat protein bind human TATA-binding protein in vitro.

BTAF1 TAF10

2.60e-04165228680883
Pubmed

A novel LBP-1-mediated restriction of HIV-1 transcription at the level of elongation in vitro.

BTAF1 TAF10

2.60e-04165227836461
Pubmed

Novel mechanism and factor for regulation by HIV-1 Tat.

BTAF1 TAF10

2.60e-04165227835343
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

MAP1B NFIC TRPS1 BTAF1 FNBP1L TAF10 AGTPBP1

2.74e-0485752725609649
Pubmed

The in vivo Interaction Landscape of Histones H3.1 and H3.3.

ZNF592 BAZ2B CBX5 NFIC BOD1L1 BTAF1

2.86e-0460852636089195
Pubmed

Fbxo45 forms a novel ubiquitin ligase complex and is required for neuronal development.

MAP3K13 MAP3K12

2.94e-041752219398581
Pubmed

Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1.

MAP1B TRPS1 UBE2M AGTPBP1

3.05e-0421552435973513
Pubmed

Role of flanking E box motifs in human immunodeficiency virus type 1 TATA element function.

BTAF1 TAF10

3.30e-04185227933101
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

MLC1 NAV2 PLCB1 ALS2

3.62e-0422552412168954
Pubmed

Interaction of human immunodeficiency virus type 1 Tat with a unique site of TFIID inhibits negative cofactor Dr1 and stabilizes the TFIID-TFIIA complex.

BTAF1 TAF10

3.69e-04195228764062
Pubmed

Isl1Cre reveals a common Bmp pathway in heart and limb development.

BMPR1A TBX20

3.69e-041952216556916
Pubmed

Selective anchoring of TFIID to nucleosomes by trimethylation of histone H3 lysine 4.

CBX5 TAF10

4.09e-042052217884155
Pubmed

Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss.

MAP1B MDM1 RP2 AGTPBP1

4.13e-0423352432290105
Pubmed

Quantitative trait loci for body size components in mice.

ARL1 BMPR1A ZNF592

4.34e-049852316783635
Pubmed

Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning.

BMPR1A TBX20

5.44e-042352216314491
Pubmed

DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.

NFIC BOD1L1 RAD54L2 TAF10 THOC2

5.76e-0445352529656893
Pubmed

Majority of cerebrospinal fluid-contacting neurons in the spinal cord of C57Bl/6N mice is present in ectopic position unlike in other studied experimental mice strains and mammalian species.

ZP2 SPATA31A5

5.93e-042452232212159
Pubmed

Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.

DRG2 NFIC OS9 UBE2M BOD1L1 APOB SHOC2 DERA

6.40e-04129752833545068
Pubmed

A single-cell time-lapse of mouse prenatal development from gastrula to birth.

PLCB1 MUC16

6.43e-042552238355799
Pubmed

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.

ZNF592 CBX5 NFIC TRPS1 UBE2M BOD1L1 THOC2

7.48e-04101452732416067
Pubmed

Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2.

NAV2 EPAS1

8.67e-042952216966370
Pubmed

Analysis of lipid pathway genes indicates association of sequence variation near SREBF1/TOM1L2/ATPAF2 with dementia risk.

ABCA2 APOB

8.67e-042952220167577
Pubmed

Isolation and characterization of proteins associated with histone H3 tails in vivo.

CBX5 ASH1L

9.29e-043052217403666
Pubmed

The tissue-specific transcriptomic landscape of the mid-gestational mouse embryo.

UBE2M TBX20

9.29e-043052224803591
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

ERCC5 ZNF592 NFIC BTAF1 THOC2 AGTPBP1

1.02e-0377452615302935
Pubmed

Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.

ZNF592 CBX5 ASH1L TAF10 THOC2

1.19e-0353352530554943
Pubmed

Characterization of the piRNA complex from rat testes.

MLC1 CBX5 RAD54L2

1.22e-0314052316778019
Pubmed

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.

NRAP ZNF592 TRPS1 ASH1L TBX20 EPAS1

1.27e-0380852620412781
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

BMPR1A ZNF592 CBX5 TRPS1 ASH1L TAF10 AGTPBP1

1.30e-03111652731753913
Pubmed

Spatiotemporal single-cell regulatory atlas reveals neural crest lineage diversification and cellular function during tooth morphogenesis.

PHEX RAB3B

1.41e-033752235974052
Pubmed

Genetic mapping of six mouse peroxiredoxin genes and fourteen peroxiredoxin related sequences.

NRAP MAP1B

1.49e-033852210501973
GeneFamilyMitogen-activated protein kinase kinase kinases|RAF family

MAP3K13 MAP3K12

9.23e-0424342654
ToppCellCOVID-19-Heart|COVID-19 / Disease (COVID-19 only), tissue and cell type

NRAP MAP1B PLCB1 CMYA5 TBX20

2.82e-06190525918ad5037881212008f9f69d5df5da91fd01422c
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-4M|organoid_Kanton_Nature / Sample Type, Dataset, Time_group, and Cell type.

TCEAL2 BOD1L1 FNBP1L RAD54L2 TMEM123

3.53e-06199525b2d7dea11207cca63d688f8051143850b29dbdf0
ToppCellNS-moderate-d_0-4-Epithelial|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

BAZ2B NFIC MUC16 MAP3K13 TMEM123

3.62e-0620052564462a18afca3c1a8548a857924b8166058bf958
DrugSAHA; Up 200; 10uM; MCF7; HT_HG-U133A

MAP1B NAV2 RP2 RGS2 EPAS1 AGTPBP1

2.67e-061805066939_UP
DrugTrichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT_HG-U133A

MAP1B NAV2 RP2 RGS2 AGTPBP1

3.95e-051745057179_UP
DrugTrichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT_HG-U133A

MAP1B MAP3K13 RAB3B RGS2 EPAS1

4.28e-051775054954_UP
Drugtrichostatin A, Streptomyces sp.; Up 200; 1uM; MCF7; HT_HG-U133A

MAP1B NAV2 RP2 RGS2 EPAS1

4.89e-051825056879_UP
Drugtrichostatin A, Streptomyces sp.; Up 200; 1uM; MCF7; HT_HG-U133A

MAP1B MDM1 NAV2 RP2 RGS2

5.29e-051855056916_UP
Drugradicicol; Up 200; 0.1uM; MCF7; HT_HG-U133A_EA

CYLC1 PHEX MAP1B MAP3K13 RGS2

5.85e-05189505836_UP
Drug0317956-0000 [391210-11-0]; Down 200; 10uM; MCF7; HT_HG-U133A

NAV2 PLCB1 RAD54L2 RGS2 EPAS1

6.00e-051905053966_DN
DrugTetrahydrozoline hydrochloride [522-48-5]; Down 200; 16.8uM; MCF7; HT_HG-U133A

CYLC1 PHEX MAP1B PLCB1 MAP3K12

6.00e-051905056769_DN
Drug5211181; Up 200; 12uM; MCF7; HT_HG-U133A_EA

MAP1B PLCB1 RAD54L2 MAP3K12 GPR107

6.46e-05193505950_UP
DrugPindolol [13523-86-9]; Down 200; 16.2uM; MCF7; HT_HG-U133A

PHEX ABCA2 PLCB1 RGS2 GPR107

6.78e-051955056834_DN
DrugRapamycin; Up 200; 0.1uM; MCF7; HT_HG-U133A_EA

ZNF592 ASH1L BSDC1 PLCB1 GPR107

6.78e-051955051045_UP
DrugPancuronium bromide [15500-66-0]; Down 200; 5.4uM; MCF7; HT_HG-U133A

ABCA2 ZNF592 ASH1L BSDC1 RP2

6.95e-051965057329_DN
DrugFoliosidine [2520-38-9]; Down 200; 13uM; MCF7; HT_HG-U133A

ABCA2 ZNF592 PLCB1 RAD54L2 GPR107

6.95e-051965056057_DN
DrugCotinine (-) [486-56-6]; Down 200; 22.6uM; HL60; HG-U133A

ABCA2 DRG2 NFIC BSDC1 GPR107

7.12e-051975052011_DN
DrugPHA-00767505E [723337-45-9]; Up 200; 10uM; MCF7; HT_HG-U133A

CYLC1 TCEAL2 MDM1 NAV2 GPR107

7.29e-051985056596_UP
Drugclotrimazole; Down 200; 50uM; MCF7; HT_HG-U133A_EA

ABCA2 ASH1L RP2 RAD54L2 GPR107

7.29e-05198505905_DN
DrugCyproheptadine hydrochloride [969-33-5]; Up 200; 12.4uM; PC3; HG-U133A

NFIC TRPS1 RP2 FNBP1L AGTPBP1

7.29e-051985051938_UP
DrugSulfabenzamide [127-71-9]; Down 200; 14.4uM; HL60; HT_HG-U133A

CYLC1 TRPS1 ASH1L FNBP1L RAD54L2

7.29e-051985052159_DN
DrugProbucol [23288-49-5]; Down 200; 7.8uM; MCF7; HT_HG-U133A

ABCA2 MAP1B ASH1L NAV2 PLCB1

7.47e-051995053223_DN
Drugretinoic acid; Up 200; 1uM; PC3; HG-U133A

ABCA2 DRG2 PLCB1 RP2 RAB3B

7.47e-05199505447_UP
Diseasetriglyceride change measurement, intermediate density lipoprotein measurement

ARL1 BMPR1A

1.55e-054482EFO_0007681, EFO_0008595
Diseaseadverse effect, response to xenobiotic stimulus

ABCA2 NAV2 PLCB1

1.23e-0459483EFO_0009658, GO_0009410
Diseaseamenorrhea, response to antineoplastic agent

APOB DERA

2.68e-0415482EFO_0010269, GO_0097327
Diseaseaggressive behavior

PHEX TBX20

7.59e-0425482EFO_0003015
Diseasesleep duration, high density lipoprotein cholesterol measurement

CARMIL2 TRPS1 APOB

1.02e-03121483EFO_0004612, EFO_0005271

Protein segments in the cluster

PeptideGeneStartEntry
NGSGFGKKSKDMSTE

EPAS1

151

Q99814
DFKMGGASDVSTAKS

ASH1L

531

Q9NR48
MGKKTKRTADSSSSE

CBX5

1

P45973
KLATEGSSGATEKMK

BSDC1

61

Q9NW68
GSSGATEKMKKGLSD

BSDC1

66

Q9NW68
MDSKKRSSTEAEGSK

ALS2

1

Q96Q42
KKAMESSSNSDSDSG

BAZ2B

236

Q9UIF8
IKKAGSDGDIMDSST

CARMIL2

1241

Q6F5E8
FKTSATKGTGLDEAM

ARL1

156

P40616
GTKGKGEDSTLASSM

RAD54L2

661

Q9Y4B4
DSGFGKETAKKLDSM

HSD11B2

91

P80365
ISSKGDEGEKKSTFM

AGTPBP1

481

Q9UPW5
MASVTDGKTGVKDAS

RAB3B

1

P20337
DGGKSKRSTVDSKAM

GPR107

176

Q5VW38
MSTALGSTENTGKEK

MUC16

1796

Q8WXI7
GSFKEDTKMSISEGT

MAP1B

1511

P46821
EYEKTKGKAMGTADS

NRAP

586

Q86VF7
KKIDESDGTSANSKM

CYLC1

556

P35663
KSKADKMKEGSDSSV

MDM1

491

Q8TC05
KMKEGSDSSVSSEKG

MDM1

496

Q8TC05
SMGKTSGKLFDSSDD

NOL8

826

Q76FK4
SKELSDKSTKMSFAG

MAP3K13

301

O43283
TTTMHSEAKKGSKFD

TMEM123

151

Q8N131
VDSMSGTEKGSKDTD

BOD1L1

1931

Q8NFC6
EGTKKMGLAFESTKS

APOB

301

P04114
DGTISASKQESGKMD

FNBP1L

296

Q5T0N5
AEKADTSTSGKASMK

BTAF1

1806

O14981
KGGSVDITKESMKEG

CMYA5

2771

Q8N3K9
HGTGMKSDSDQKKSE

BMPR1A

31

P36894
AGKTSTFKMLTGDES

ABCA2

2091

Q9BZC7
GTSKELSDKSTKMSF

MAP3K12

256

Q12852
MAGSDFIKTSTGKET

DERA

211

Q9Y315
MDKSAGSGHKSEEKR

RGS2

16

P41220
MKGTASGSSRSKSKD

TAF10

176

Q12962
IMKVKSDGSHSKGDG

IGLV4-3

66

A0A075B6K6
TGKESSKSMTVKVSG

PSG8

401

Q9UQ74
SSSSDSDDDGGKEKM

ERCC5

1146

P28715
DVKKSDGGSDSGIKM

NAV2

1011

Q8IVL1
MSSSLGKEKDSKEKD

SHOC2

1

Q9UQ13
KSASSKGEGFDVMKS

DRG2

46

P55039
SSGSKRHKSGSMEED

NFIC

276

P08651
MAGASPTKDDSKDSD

OS9

296

Q13438
EGETMTKTDKSSSGA

TRPS1

491

Q9UHF7
SGKEKGSDSFKSEKM

THOC2

1536

Q8NI27
GSDSFKSEKMDKISS

THOC2

1541

Q8NI27
SMSTGEGSKEAQKVK

SPATA31A5

646

Q5VU36
RKGDESMTKASDSSS

ZNF592

446

Q92610
GTKMFVSESKETASG

RP2

321

O75695
MEAETGSSVETGKKA

PHEX

1

P78562
SERKGKSEMQGGSKT

TCEAL2

76

Q9H3H9
KKSSMDEGTAGSEAM

PLCB1

521

Q9NQ66
AALMSSGGSKEKEAT

TBX20

21

Q9UMR3
MDTKGHKTAGDVGSK

ZP2

701

Q05996
KKEEESAGGTKGSSK

UBE2M

11

P61081
SSEEDCKKKKGSMSD

MLC1

166

Q15049