Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	DPEP1 APOBEC3D NADSYN1 PADI6 APOBEC3B	2.34e-05	146	47	5	GO:0016810
GeneOntologyMolecularFunction	Toll-like receptor 2 binding	TLR1 TLR6	3.24e-05	4	47	2	GO:0035663
GeneOntologyMolecularFunction	ABC-type glutathione S-conjugate transporter activity	ABCC4 ABCC2	1.50e-04	8	47	2	GO:0015431
GeneOntologyMolecularFunction	UDP phosphatase activity	CANT1 ENTPD8	1.93e-04	9	47	2	GO:0045134
GeneOntologyMolecularFunction	ATPase-coupled inorganic anion transmembrane transporter activity	ABCC4 ABCC2	2.41e-04	10	47	2	GO:0043225
GeneOntologyMolecularFunction	lipopeptide binding	TLR1 TLR6	2.41e-04	10	47	2	GO:0071723
GeneOntologyMolecularFunction	GDP phosphatase activity	CANT1 ENTPD8	3.53e-04	12	47	2	GO:0004382
GeneOntologyMolecularFunction	cytidine deaminase activity	APOBEC3D APOBEC3B	4.16e-04	13	47	2	GO:0004126
GeneOntologyMolecularFunction	G protein-coupled neurotransmitter receptor activity	HRH4 GRM1	4.16e-04	13	47	2	GO:0099528
GeneOntologyMolecularFunction	ABC-type xenobiotic transporter activity	ABCC4 ABCC2	5.58e-04	15	47	2	GO:0008559
GeneOntologyMolecularFunction	NAD+ nucleotidase, cyclic ADP-ribose generating	TLR1 TLR6	6.37e-04	16	47	2	GO:0061809
GeneOntologyMolecularFunction	nucleoside diphosphate phosphatase activity	CANT1 ENTPD8	1.00e-03	20	47	2	GO:0017110
GeneOntologyMolecularFunction	Toll-like receptor binding	TLR1 TLR6	2.11e-03	29	47	2	GO:0035325
GeneOntologyMolecularFunction	deaminase activity	APOBEC3D APOBEC3B	2.90e-03	34	47	2	GO:0019239
GeneOntologyMolecularFunction	xenobiotic transmembrane transporter activity	ABCC4 ABCC2	2.90e-03	34	47	2	GO:0042910
GeneOntologyMolecularFunction	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	APOBEC3D APOBEC3B	3.25e-03	36	47	2	GO:0016814
GeneOntologyMolecularFunction	hydrolase activity, hydrolyzing N-glycosyl compounds	TLR1 TLR6	4.19e-03	41	47	2	GO:0016799
GeneOntologyMolecularFunction	amide transmembrane transporter activity	ABCC4 AQP8	4.40e-03	42	47	2	GO:0042887
GeneOntologyBiologicalProcess	antibiotic metabolic process	DPEP1 ABCC2	4.65e-06	2	45	2	GO:0016999
GeneOntologyBiologicalProcess	detection of bacterial lipopeptide	TLR1 TLR6	1.39e-05	3	45	2	GO:0070340
GeneOntologyBiologicalProcess	lactam metabolic process	DPEP1 ABCC2	2.78e-05	4	45	2	GO:0072338
GeneOntologyBiologicalProcess	detection of bacterial lipoprotein	TLR1 TLR6	2.78e-05	4	45	2	GO:0042494
GeneOntologyBiologicalProcess	canalicular bile acid transport	AQP8 ABCC2	6.94e-05	6	45	2	GO:0015722
GeneOntologyBiologicalProcess	clearance of foreign intracellular DNA	APOBEC3D APOBEC3B	6.94e-05	6	45	2	GO:0044355
GeneOntologyBiologicalProcess	clearance of foreign intracellular nucleic acids	APOBEC3D APOBEC3B	6.94e-05	6	45	2	GO:0099046
GeneOntologyBiologicalProcess	leukotriene transport	ABCC4 ABCC2	9.71e-05	7	45	2	GO:0071716
GeneOntologyBiologicalProcess	import across plasma membrane	SLC24A4 SLC6A5 CACNA1G AQP8 GRM1	1.40e-04	230	45	5	GO:0098739
GeneOntologyBiologicalProcess	bile acid and bile salt transport	ABCC4 AQP8 ABCC2	1.47e-04	47	45	3	GO:0015721
GeneOntologyBiologicalProcess	cellular response to bacterial lipoprotein	TLR1 TLR6	2.07e-04	10	45	2	GO:0071220
GeneOntologyBiologicalProcess	cellular response to bacterial lipopeptide	TLR1 TLR6	2.07e-04	10	45	2	GO:0071221
GeneOntologyBiologicalProcess	DNA cytosine deamination	APOBEC3D APOBEC3B	2.07e-04	10	45	2	GO:0070383
GeneOntologyBiologicalProcess	response to bacterial lipopeptide	TLR1 TLR6	2.07e-04	10	45	2	GO:0070339
GeneOntologyBiologicalProcess	negative regulation of viral genome replication	APOBEC3D RSAD2 APOBEC3B	2.48e-04	56	45	3	GO:0045071
GeneOntologyBiologicalProcess	carboxylic acid transport	ABCC4 AVPR1A SLC6A5 AQP8 ABCC2 GRM1	2.51e-04	410	45	6	GO:0046942
GeneOntologyBiologicalProcess	response to bacterial lipoprotein	TLR1 TLR6	2.53e-04	11	45	2	GO:0032493
GeneOntologyBiologicalProcess	organic acid transport	ABCC4 AVPR1A SLC6A5 AQP8 ABCC2 GRM1	2.58e-04	412	45	6	GO:0015849
GeneOntologyBiologicalProcess	cytidine to uridine editing	APOBEC3D APOBEC3B	3.03e-04	12	45	2	GO:0016554
GeneOntologyBiologicalProcess	regulation of toll-like receptor 2 signaling pathway	TLR1 TLR6	3.58e-04	13	45	2	GO:0034135
GeneOntologyBiologicalProcess	cytidine metabolic process	APOBEC3D APOBEC3B	4.17e-04	14	45	2	GO:0046087
GeneOntologyBiologicalProcess	cytidine catabolic process	APOBEC3D APOBEC3B	4.17e-04	14	45	2	GO:0006216
GeneOntologyBiologicalProcess	cytidine deamination	APOBEC3D APOBEC3B	4.17e-04	14	45	2	GO:0009972
GeneOntologyBiologicalProcess	DNA deamination	APOBEC3D APOBEC3B	4.17e-04	14	45	2	GO:0045006
GeneOntologyBiologicalProcess	detection of molecule of bacterial origin	TLR1 TLR6	5.48e-04	16	45	2	GO:0032490
GeneOntologyBiologicalProcess	negative regulation of single stranded viral RNA replication via double stranded DNA intermediate	APOBEC3D APOBEC3B	5.48e-04	16	45	2	GO:0045869
GeneOntologyBiologicalProcess	pyrimidine ribonucleoside metabolic process	APOBEC3D APOBEC3B	5.48e-04	16	45	2	GO:0046131
GeneOntologyBiologicalProcess	pyrimidine ribonucleoside catabolic process	APOBEC3D APOBEC3B	5.48e-04	16	45	2	GO:0046133
GeneOntologyBiologicalProcess	activation of NF-kappaB-inducing kinase activity	TLR1 TLR6	6.20e-04	17	45	2	GO:0007250
GeneOntologyBiologicalProcess	positive regulation of pattern recognition receptor signaling pathway	RSAD2 TLR1 TLR6	6.83e-04	79	45	3	GO:0062208
GeneOntologyBiologicalProcess	pyrimidine nucleoside catabolic process	APOBEC3D APOBEC3B	6.96e-04	18	45	2	GO:0046135
GeneOntologyBiologicalProcess	xenobiotic transmembrane transport	ABCC4 ABCC2	7.77e-04	19	45	2	GO:0006855
GeneOntologyBiologicalProcess	regulation of single stranded viral RNA replication via double stranded DNA intermediate	APOBEC3D APOBEC3B	7.77e-04	19	45	2	GO:0045091
GeneOntologyBiologicalProcess	base conversion or substitution editing	APOBEC3D APOBEC3B	7.77e-04	19	45	2	GO:0016553
GeneOntologyBiologicalProcess	toll-like receptor 2 signaling pathway	TLR1 TLR6	7.77e-04	19	45	2	GO:0034134
GeneOntologyBiologicalProcess	organic anion transport	ABCC4 AVPR1A SLC6A5 AQP8 ABCC2 GRM1	8.39e-04	515	45	6	GO:0015711
GeneOntologyBiologicalProcess	detection of bacterium	TLR1 TLR6	8.62e-04	20	45	2	GO:0016045
GeneOntologyBiologicalProcess	single stranded viral RNA replication via double stranded DNA intermediate	APOBEC3D APOBEC3B	8.62e-04	20	45	2	GO:0039692
GeneOntologyBiologicalProcess	transport across blood-brain barrier	ABCC4 AVPR1A ABCC2	9.05e-04	87	45	3	GO:0150104
GeneOntologyBiologicalProcess	vascular transport	ABCC4 AVPR1A ABCC2	9.35e-04	88	45	3	GO:0010232
GeneOntologyBiologicalProcess	export across plasma membrane	ABCC4 SLC24A4 ABCC2	1.03e-03	91	45	3	GO:0140115
GeneOntologyBiologicalProcess	regulation of viral genome replication	APOBEC3D RSAD2 APOBEC3B	1.03e-03	91	45	3	GO:0045069
GeneOntologyBiologicalProcess	detection of other organism	TLR1 TLR6	1.14e-03	23	45	2	GO:0098543
GeneOntologyBiologicalProcess	ribonucleoside catabolic process	APOBEC3D APOBEC3B	1.46e-03	26	45	2	GO:0042454
GeneOntologyBiologicalProcess	negative regulation of viral process	APOBEC3D RSAD2 APOBEC3B	1.47e-03	103	45	3	GO:0048525
GeneOntologyBiologicalProcess	pyrimidine nucleoside metabolic process	APOBEC3D APOBEC3B	1.58e-03	27	45	2	GO:0006213
GeneOntologyBiologicalProcess	DNA modification	APOBEC3D APOBEC3B	2.08e-03	31	45	2	GO:0006304
GeneOntologyBiologicalProcess	small molecule catabolic process	DPEP1 APOBEC3D ACAD10 QDPR APOBEC3B	2.16e-03	421	45	5	GO:0044282
GeneOntologyBiologicalProcess	viral RNA genome replication	APOBEC3D APOBEC3B	2.21e-03	32	45	2	GO:0039694
GeneOntologyBiologicalProcess	nucleoside catabolic process	APOBEC3D APOBEC3B	2.21e-03	32	45	2	GO:0009164
GeneOntologyBiologicalProcess	dicarboxylic acid transport	AVPR1A ABCC2 GRM1	2.28e-03	120	45	3	GO:0006835
GeneOntologyBiologicalProcess	detection of external biotic stimulus	TLR1 TLR6	2.35e-03	33	45	2	GO:0098581
GeneOntologyCellularComponent	intracellular canaliculus	AQP8 ABCC2	5.14e-05	5	48	2	GO:0046691
MousePheno	abnormal glomerular filtration barrier function	LAMB2 GRM1	4.30e-05	4	38	2	MP:0011856
Domain	Toll-like_receptor	TLR1 TLR6	5.91e-05	5	46	2	IPR017241
Domain	APOBEC_N	APOBEC3D APOBEC3B	3.86e-04	12	46	2	PF08210
Domain	APOBEC_N	APOBEC3D APOBEC3B	3.86e-04	12	46	2	IPR013158
Domain	APOBEC/CMP_deaminase_Zn-bd	APOBEC3D APOBEC3B	5.30e-04	14	46	2	IPR016192
Domain	CYT_DCMP_DEAMINASES_1	APOBEC3D APOBEC3B	7.88e-04	17	46	2	PS00903
Domain	CMP_dCMP_Zn-bd	APOBEC3D APOBEC3B	7.88e-04	17	46	2	IPR002125
Domain	Cytidine_deaminase-like	APOBEC3D APOBEC3B	7.88e-04	17	46	2	IPR016193
Domain	TIR	TLR1 TLR6	1.21e-03	21	46	2	SM00255
Domain	TIR	TLR1 TLR6	1.33e-03	22	46	2	PF01582
Domain	Cys-rich_flank_reg_C	TLR1 TLR6 GP1BA	1.41e-03	90	46	3	IPR000483
Domain	LRRCT	TLR1 TLR6 GP1BA	1.41e-03	90	46	3	SM00082
Domain	-	TLR1 TLR6	1.45e-03	23	46	2	3.40.50.10140
Domain	TIR	TLR1 TLR6	1.58e-03	24	46	2	PS50104
Domain	ABC_membrane	ABCC4 ABCC2	1.58e-03	24	46	2	PF00664
Domain	TIR_dom	TLR1 TLR6	1.72e-03	25	46	2	IPR000157
Domain	ABC_TM1F	ABCC4 ABCC2	2.15e-03	28	46	2	PS50929
Domain	ABC1_TM_dom	ABCC4 ABCC2	2.15e-03	28	46	2	IPR011527
Domain	ArfGap	SMAP1 SMAP2	2.31e-03	29	46	2	SM00105
Domain	ARFGAP	SMAP1 SMAP2	2.31e-03	29	46	2	PS50115
Domain	ArfGAP	SMAP1 SMAP2	2.31e-03	29	46	2	IPR001164
Domain	ArfGap	SMAP1 SMAP2	2.31e-03	29	46	2	PF01412
Domain	LRRCT	TLR1 TLR6	2.81e-03	32	46	2	PF01463
Domain	ABC_transporter_CS	ABCC4 ABCC2	4.80e-03	42	46	2	IPR017871
Domain	Rossmann-like_a/b/a_fold	NADSYN1 VARS1	5.03e-03	43	46	2	IPR014729
Domain	-	NADSYN1 VARS1	5.03e-03	43	46	2	3.40.50.620
Domain	ABC_TRANSPORTER_2	ABCC4 ABCC2	6.23e-03	48	46	2	PS50893
Domain	ABC_tran	ABCC4 ABCC2	6.23e-03	48	46	2	PF00005
Domain	ABC_TRANSPORTER_1	ABCC4 ABCC2	6.48e-03	49	46	2	PS00211
Domain	ABC_transporter-like	ABCC4 ABCC2	6.74e-03	50	46	2	IPR003439
Domain	LRR_8	TLR1 TLR6 GP1BA	8.58e-03	171	46	3	PF13855
Domain	Leu-rich_rpt_typical-subtyp	TLR1 TLR6 GP1BA	9.42e-03	177	46	3	IPR003591
Domain	LRR_TYP	TLR1 TLR6 GP1BA	9.42e-03	177	46	3	SM00369
Pubmed	Species-specific recognition of Aspergillus fumigatus by Toll-like receptor 1 and Toll-like receptor 6.	TLR1 TLR6	1.94e-06	2	49	2	22315281
Pubmed	Activity-dependent gating of calcium spikes by A-type K+ channels controls climbing fiber signaling in Purkinje cell dendrites.	CACNA1G GRM1	1.94e-06	2	49	2	25220810
Pubmed	Role of TLR1 and TLR6 in the host defense against disseminated candidiasis.	TLR1 TLR6	1.94e-06	2	49	2	18036178
Pubmed	Association between ABCC2 gene haplotypes and tenofovir-induced proximal tubulopathy.	ABCC4 ABCC2	1.94e-06	2	49	2	17083032
Pubmed	The association of genetic variants in toll-like receptor 2 subfamily with allergy and asthma after hospitalization for bronchiolitis in infancy.	TLR1 TLR6	1.94e-06	2	49	2	24445834
Pubmed	The Roles of TLR Gene Polymorphisms in Atherosclerosis: A Systematic Review and Meta-Analysis of 35,317 Subjects.	TLR1 TLR6	1.94e-06	2	49	2	28474755
Pubmed	[DISTRIBUTION OF TWO-LOCUS HAPLOTYPES OF MICROBIAL COMPONENT SENSOR GENES TLR1 AND TLR6 IN MAJOR POPULATIONS OF SOUTH URALS].	TLR1 TLR6	1.94e-06	2	49	2	26470427
Pubmed	Association of human TLR1 and TLR6 deficiency with altered immune responses to BCG vaccination in South African infants.	TLR1 TLR6	1.94e-06	2	49	2	21852947
Pubmed	Toll-like Receptor 1 743 A>G, 1805 T>G & Toll-like Receptor 6 745 C>T gene polymorphism and tuberculosis: a case control study of north Indian population from Agra (India).	TLR1 TLR6	1.94e-06	2	49	2	24984237
Pubmed	The Arf GTPase-activating protein SMAP1 promotes transferrin receptor endocytosis and interacts with SMAP2.	SMAP1 SMAP2	1.94e-06	2	49	2	25281535
Pubmed	Polymorphisms in the methotrexate transport pathway: a new tool for MTX plasma level prediction in pediatric acute lymphoblastic leukemia.	ABCC4 ABCC2	1.94e-06	2	49	2	23222202
Pubmed	Influence of ABCC2 and ABCC4 polymorphisms on tenofovir plasma concentrations in Thai HIV-infected patients.	ABCC4 ABCC2	1.94e-06	2	49	2	25801567
Pubmed	A specific role for TLR1 in protective T(H)17 immunity during mucosal infection.	TLR1 TLR6	1.94e-06	2	49	2	22778390
Pubmed	Mice doubly-deficient in the Arf GAPs SMAP1 and SMAP2 exhibit embryonic lethality.	SMAP1 SMAP2	1.94e-06	2	49	2	26296315
Pubmed	Cutting edge: functional interactions between toll-like receptor (TLR) 2 and TLR1 or TLR6 in response to phenol-soluble modulin.	TLR1 TLR6	1.94e-06	2	49	2	11123271
Pubmed	SNPs in the exons of Toll-like receptors are associated with susceptibility to type 1 diabetes in Chinese population.	TLR1 TLR6	1.94e-06	2	49	2	25261617
Pubmed	Genetic ancestry effects on the distribution of toll-like receptors (TLRs) gene polymorphisms in a population of the Atlantic Forest, São Paulo, Brazil.	TLR1 TLR6	1.94e-06	2	49	2	29175392
Pubmed	Murine Leukemia Virus P50 Protein Counteracts APOBEC3 by Blocking Its Packaging.	APOBEC3D APOBEC3B	5.83e-06	3	49	2	32641479
Pubmed	APOBEC3 deletion increases the risk of breast cancer: a meta-analysis.	APOBEC3D APOBEC3B	5.83e-06	3	49	2	27602762
Pubmed	Recognition of lipopeptide patterns by Toll-like receptor 2-Toll-like receptor 6 heterodimer.	TLR1 TLR6	5.83e-06	3	49	2	19931471
Pubmed	Anti-Friend virus antibody is associated with recovery from viremia and loss of viral leukemia cell-surface antigens in leukemic mice. Identification of Rfv-3 as a gene locus influencing antibody production.	APOBEC3D APOBEC3B	5.83e-06	3	49	2	286744
Pubmed	A novel role for APOBEC3: susceptibility to sexual transmission of murine acquired immunodeficiency virus (mAIDS) is aggravated in APOBEC3 deficient mice.	APOBEC3D APOBEC3B	5.83e-06	3	49	2	22691411
Pubmed	Hepatocellular Shuttling and Recirculation of Sorafenib-Glucuronide Is Dependent on Abcc2, Abcc3, and Oatp1a/1b.	ABCC4 ABCC2	5.83e-06	3	49	2	25952649
Pubmed	Studies on the restriction of murine leukemia viruses by mouse APOBEC3.	APOBEC3D APOBEC3B	5.83e-06	3	49	2	22666481
Pubmed	Divergent roles of amino acid residues inside and outside the BB loop affect human Toll-like receptor (TLR)2/2, TLR2/1 and TLR2/6 responsiveness.	TLR1 TLR6	5.83e-06	3	49	2	23626692
Pubmed	APOBEC3 deletion polymorphism is associated with epithelial ovarian cancer risk among Chinese women.	APOBEC3D APOBEC3B	5.83e-06	3	49	2	24577894
Pubmed	Sequence variants in Toll-like receptor gene cluster (TLR6-TLR1-TLR10) and prostate cancer risk.	TLR1 TLR6	5.83e-06	3	49	2	15812078
Pubmed	Host restriction of murine gammaherpesvirus 68 replication by human APOBEC3 cytidine deaminases but not murine APOBEC3.	APOBEC3D APOBEC3B	5.83e-06	3	49	2	24725948
Pubmed	APOBEC3B and APOBEC3F inhibit L1 retrotransposition by a DNA deamination-independent mechanism.	APOBEC3D APOBEC3B	5.83e-06	3	49	2	16648136
Pubmed	Heterozygous Arg753Gln polymorphism of human TLR-2 impairs immune activation by Borrelia burgdorferi and protects from late stage Lyme disease.	TLR1 TLR6	5.83e-06	3	49	2	16081826
Pubmed	Fv1 restriction and retrovirus vaccine immunity in Apobec3-deficient 129P2 mice.	APOBEC3D APOBEC3B	5.83e-06	3	49	2	23533681
Pubmed	The glycosylated Gag protein of a murine leukemia virus inhibits the antiretroviral function of APOBEC3.	APOBEC3D APOBEC3B	5.83e-06	3	49	2	20702647
Pubmed	Spontaneous recovery from Friend retrovirus-induced leukemia. Mapping of the Rfv-2 gene in the Q/TL region of mouse MHC.	APOBEC3D APOBEC3B	5.83e-06	3	49	2	1541833
Pubmed	In Vivo Examination of Mouse APOBEC3- and Human APOBEC3A- and APOBEC3G-Mediated Restriction of Parvovirus and Herpesvirus Infection in Mouse Models.	APOBEC3D APOBEC3B	5.83e-06	3	49	2	27356895
Pubmed	Application of multivariate statistical procedures to identify transcription factors that correlate with MRP2, 3, and 4 mRNA in adult human livers.	ABCC4 ABCC2	5.83e-06	3	49	2	19480556
Pubmed	IFN-α treatment inhibits acute Friend retrovirus replication primarily through the antiviral effector molecule Apobec3.	APOBEC3D APOBEC3B	5.83e-06	3	49	2	23315078
Pubmed	Persistent Friend virus replication and disease in Apobec3-deficient mice expressing functional B-cell-activating factor receptor.	APOBEC3D APOBEC3B	5.83e-06	3	49	2	20980520
Pubmed	Epistatic effect of TLR-1, -6 and -10 polymorphisms on organic dust-mediated cytokine response.	TLR1 TLR6	5.83e-06	3	49	2	28123183
Pubmed	Genetic variation in the toll-like receptor gene cluster (TLR10-TLR1-TLR6) and prostate cancer risk.	TLR1 TLR6	5.83e-06	3	49	2	18752252
Pubmed	Requirement for Fc effector mechanisms in the APOBEC3/Rfv3-dependent neutralizing antibody response.	APOBEC3D APOBEC3B	5.83e-06	3	49	2	25589647
Pubmed	Identification of a non-H-2 gene (Rfv-3) influencing recovery from viremia and leukemia induced by Friend virus complex.	APOBEC3D APOBEC3B	5.83e-06	3	49	2	284359
Pubmed	Atherosclerosis induced by endogenous and exogenous toll-like receptor (TLR)1 or TLR6 agonists.	TLR1 TLR6	5.83e-06	3	49	2	22822027
Pubmed	Adaptive evolution of Mus Apobec3 includes retroviral insertion and positive selection at two clusters of residues flanking the substrate groove.	APOBEC3D APOBEC3B	5.83e-06	3	49	2	20617165
Pubmed	Impact of Suboptimal APOBEC3G Neutralization on the Emergence of HIV Drug Resistance in Humanized Mice.	APOBEC3D APOBEC3B	5.83e-06	3	49	2	31801862
Pubmed	Apobec-mediated retroviral hypermutation in vivo is dependent on mouse strain.	APOBEC3D APOBEC3B	5.83e-06	3	49	2	39208378
Pubmed	Deamination hotspots among APOBEC3 family members are defined by both target site sequence context and ssDNA secondary structure.	APOBEC3D APOBEC3B	5.83e-06	3	49	2	31943071
Pubmed	Polymorphisms in TLR1, TLR6 and TLR10 genes and the risk of Graves' disease.	TLR1 TLR6	5.83e-06	3	49	2	25028161
Pubmed	Sublethal infection of C57BL/6 mice with Salmonella enterica Serovar Typhimurium leads to an increase in levels of Toll-like receptor 1 (TLR1), TLR2, and TLR9 mRNA as well as a decrease in levels of TLR6 mRNA in infected organs.	TLR1 TLR6	5.83e-06	3	49	2	15731092
Pubmed	Recognition of Coxiella burnetii by toll-like receptors and nucleotide-binding oligomerization domain-like receptors.	TLR1 TLR6	5.83e-06	3	49	2	25246533
Pubmed	TLR1, TLR2, and TLR6 gene polymorphisms are associated with increased susceptibility to complicated skin and skin structure infections.	TLR1 TLR6	5.83e-06	3	49	2	24511099
Pubmed	The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors.	TLR1 TLR6	5.83e-06	3	49	2	11095740
Pubmed	Murine leukemia virus glycosylated Gag blocks apolipoprotein B editing complex 3 and cytosolic sensor access to the reverse transcription complex.	APOBEC3D APOBEC3B	5.83e-06	3	49	2	23671100
Pubmed	Multidrug resistance proteins 2 and 3 provide alternative routes for hepatic excretion of morphine-glucuronides.	ABCC4 ABCC2	5.83e-06	3	49	2	17485564
Pubmed	Structural perspectives on HIV-1 Vif and APOBEC3 restriction factor interactions.	APOBEC3D APOBEC3B	5.83e-06	3	49	2	31518043
Pubmed	Innate retroviral restriction by Apobec3 promotes antibody affinity maturation in vivo.	APOBEC3D APOBEC3B	5.83e-06	3	49	2	20566830
Pubmed	Physiological and pharmacological functions of Mrp2, Mrp3 and Mrp4 as determined from recent studies on gene-disrupted mice.	ABCC4 ABCC2	5.83e-06	3	49	2	17273943
Pubmed	Full-exon resequencing reveals toll-like receptor variants contribute to human susceptibility to tuberculosis disease.	TLR1 TLR6	5.83e-06	3	49	2	18091991
Pubmed	TLR1 and TLR6 polymorphisms are associated with susceptibility to invasive aspergillosis after allogeneic stem cell transplantation.	TLR1 TLR6	5.83e-06	3	49	2	16461792
Pubmed	Chromosome mapping of Rfv3, a host resistance gene to Friend murine retrovirus.	APOBEC3D APOBEC3B	5.83e-06	3	49	2	7884913
Pubmed	N-linked glycosylation protects gammaretroviruses against deamination by APOBEC3 proteins.	APOBEC3D APOBEC3B	5.83e-06	3	49	2	25505062
Pubmed	Molecular analysis of γ1, γ3, and α class switch recombination junctions in APOBEC3-deficient mice using high-throughput sequencing.	APOBEC3D APOBEC3B	5.83e-06	3	49	2	31595054
Pubmed	APOBEC3 signature mutations in chronic lymphocytic leukemia.	APOBEC3D APOBEC3B	5.83e-06	3	49	2	24840555
Pubmed	Role of APOBEC3 in genetic diversity among endogenous murine leukemia viruses.	APOBEC3D APOBEC3B	5.83e-06	3	49	2	17967065
Pubmed	Toll-like receptor 2 subfamily gene polymorphisms are associated with Bacillus Calmette-Guérin osteitis following newborn vaccination.	TLR1 TLR6	5.83e-06	3	49	2	25605403
Pubmed	Saturated fatty acid activates but polyunsaturated fatty acid inhibits Toll-like receptor 2 dimerized with Toll-like receptor 6 or 1.	TLR1 TLR6	5.83e-06	3	49	2	14966134
Pubmed	Association between Toll-like receptor gene cluster (TLR6, TLR1, and TLR10) and prostate cancer.	TLR1 TLR6	5.83e-06	3	49	2	17932345
Pubmed	Inhibition of xenotropic murine leukemia virus-related virus by APOBEC3 proteins and antiviral drugs.	APOBEC3D APOBEC3B	5.83e-06	3	49	2	20335265
Pubmed	Toll-like receptor 2 subfamily genotypes are not associated with severity of bronchiolitis or postbronchiolitis wheezing in infants.	TLR1 TLR6	5.83e-06	3	49	2	24112285
Pubmed	IFNs activate toll-like receptor gene expression in viral infections.	TLR1 TLR6	5.83e-06	3	49	2	11607792
Pubmed	Variation in the TLR10/TLR1/TLR6 locus is the major genetic determinant of interindividual difference in TLR1/2-mediated responses.	TLR1 TLR6	5.83e-06	3	49	2	23151486
Pubmed	Deaminase-Dead Mouse APOBEC3 Is an In Vivo Retroviral Restriction Factor.	APOBEC3D APOBEC3B	5.83e-06	3	49	2	29593034
Pubmed	[Association of polymorphisms in toll-like receptor genes with atopic dermatitis in the Republic of Bashkortostan].	TLR1 TLR6	5.83e-06	3	49	2	25850295
Pubmed	Mouse APOBEC3 interferes with autocatalytic cleavage of murine leukemia virus Pr180gag-pol precursor and inhibits Pr65gag processing.	APOBEC3D APOBEC3B	5.83e-06	3	49	2	31830125
Pubmed	Requirement for CD4(+) T cells in the Friend murine retrovirus neutralizing antibody response: evidence for functional T cells in genetic low-recovery mice.	APOBEC3D APOBEC3B	5.83e-06	3	49	2	9765497
Pubmed	Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins.	TLR1 TLR6	5.83e-06	3	49	2	12077222
Pubmed	Noninfectious retrovirus particles drive the APOBEC3/Rfv3 dependent neutralizing antibody response.	APOBEC3D APOBEC3B	5.83e-06	3	49	2	21998583
Pubmed	Ureaplasma parvum lipoproteins, including MB antigen, activate NF-{kappa}B through TLR1, TLR2 and TLR6.	TLR1 TLR6	5.83e-06	3	49	2	18451040
Pubmed	Biochemical and biological studies of mouse APOBEC3.	APOBEC3D APOBEC3B	5.83e-06	3	49	2	24453360
Pubmed	TLR1- and TLR6-independent recognition of bacterial lipopeptides.	TLR1 TLR6	5.83e-06	3	49	2	16455646
Pubmed	Toll-like receptor polymorphisms are associated with increased neurosyphilis risk.	TLR1 TLR6	5.83e-06	3	49	2	24922103
Pubmed	Direct inhibition of human APOBEC3 deaminases by HIV-1 Vif independent of the proteolysis pathway.	APOBEC3D APOBEC3B	5.83e-06	3	49	2	38115583
Pubmed	Molecular mechanisms of TLR2-mediated antigen cross-presentation in dendritic cells.	TLR1 TLR6	5.83e-06	3	49	2	24683188
Pubmed	A dipalmitoylated lipoprotein from Mycoplasma pneumoniae activates NF-kappa B through TLR1, TLR2, and TLR6.	TLR1 TLR6	5.83e-06	3	49	2	16177110
Pubmed	Toll-like receptors 1 and 6 are involved in TLR2-mediated macrophage activation by hepatitis C virus core and NS3 proteins.	TLR1 TLR6	5.83e-06	3	49	2	17595379
Pubmed	APOBEC3 inhibition of mouse mammary tumor virus infection: the role of cytidine deamination versus inhibition of reverse transcription.	APOBEC3D APOBEC3B	5.83e-06	3	49	2	23449789
Pubmed	Genetic variation in the Toll-like receptor gene cluster (TLR10-TLR1-TLR6) influences disease course in sarcoidosis.	TLR1 TLR6	5.83e-06	3	49	2	22150367
Pubmed	Heterodimerization of TLR2 with TLR1 or TLR6 expands the ligand spectrum but does not lead to differential signaling.	TLR1 TLR6	5.83e-06	3	49	2	18056480
Pubmed	Toll-like receptor-1, -2, and -6 polymorphisms influence disease extension in inflammatory bowel diseases.	TLR1 TLR6	5.83e-06	3	49	2	16374251
Pubmed	Effects of zidovudine on Friend virus complex infection in Rfv-3r/s genotype-containing mice used as a model for HIV infection.	APOBEC3D APOBEC3B	5.83e-06	3	49	2	2157836
Pubmed	Distinctive High Expression of Antiretroviral APOBEC3 Protein in Mouse Germinal Center B Cells.	APOBEC3D APOBEC3B	5.83e-06	3	49	2	35458563
Pubmed	Two genetic determinants acquired late in Mus evolution regulate the inclusion of exon 5, which alters mouse APOBEC3 translation efficiency.	APOBEC3D APOBEC3B	5.83e-06	3	49	2	22275865
Pubmed	APOBEC3-independent interferon-induced viral clearance in hepatitis B virus transgenic mice.	APOBEC3D APOBEC3B	5.83e-06	3	49	2	18434399
Pubmed	TLR1/TLR2 heterodimers play an important role in the recognition of Borrelia spirochetes.	TLR1 TLR6	5.83e-06	3	49	2	21998742
Pubmed	Species difference in the inhibitory effect of nonsteroidal anti-inflammatory drugs on the uptake of methotrexate by human kidney slices.	ABCC4 ABCC2	5.83e-06	3	49	2	17578901
Pubmed	Induction of APOBEC3 in vivo causes increased restriction of retrovirus infection.	APOBEC3D APOBEC3B	5.83e-06	3	49	2	19153238
Pubmed	Apobec3 encodes Rfv3, a gene influencing neutralizing antibody control of retrovirus infection.	APOBEC3D APOBEC3B	5.83e-06	3	49	2	18772436
Pubmed	Soluble Toll-like receptor 1 family members in the amniotic fluid of women with preterm prelabor rupture of the membranes.	TLR1 TLR6	5.83e-06	3	49	2	22280448
Pubmed	Toll-like receptor 1, 2 and 6 polymorphisms: no association with 11 serum cytokine concentrations.	TLR1 TLR6	5.83e-06	3	49	2	30028533
Pubmed	Antibody-induced modulation of Friend virus cell surface antigens decreases virus production by persistent erythroleukemia cells: influence of the Rfv-3 gene.	APOBEC3D APOBEC3B	5.83e-06	3	49	2	293683
Pubmed	Enhanced replication and pathogenesis of Moloney murine leukemia virus in mice defective in the murine APOBEC3 gene.	APOBEC3D APOBEC3B	5.83e-06	3	49	2	19150103
Cytoband	3q27.1	ALG3 ECE2	3.85e-04	27	49	2	3q27.1
Cytoband	4p14	TLR1 TLR6	9.35e-04	42	49	2	4p14
Cytoband	Ensembl 112 genes in cytogenetic band chr4p14	TLR1 TLR6	2.36e-03	67	49	2	chr4p14
GeneFamily	CD molecules\|Toll like receptors	TLR1 TLR6	1.44e-04	10	33	2	948
GeneFamily	Apolipoprotein B mRNA editing enzyme catalytic subunits	APOBEC3D APOBEC3B	2.11e-04	12	33	2	406
GeneFamily	ATP binding cassette subfamily C	ABCC4 ABCC2	2.49e-04	13	33	2	807
GeneFamily	ArfGAPs	SMAP1 SMAP2	1.65e-03	33	33	2	395
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	TLR1 TLR6 GP1BA	3.46e-02	394	33	3	471
GeneFamily	Solute carriers	SLC24A4 SLC6A5 SLC35F5	3.48e-02	395	33	3	752
Coexpression	WANG_MLL_TARGETS	DPEP1 APOBEC3D AVPR1A DEF6 CACNA1G APOBEC3B	1.52e-05	306	46	6	MM1076
Coexpression	GSE11961_UNSTIM_VS_ANTI_IGM_AND_CD40_STIM_6H_FOLLICULAR_BCELL_DN	RSAD2 MYCBP2 CANT1 TLR1 TLR6	2.62e-05	200	46	5	M9335
Coexpression	GSE15735_CTRL_VS_HDAC_INHIBITOR_TREATED_CD4_TCELL_2H_DN	PLEKHA6 TLR6 SMAP2 APOBEC3B VARS1	2.62e-05	200	46	5	M7161
ToppCell	PBMC-Mild-cDC_9\|Mild / Compartment, Disease Groups and Clusters	APOBEC3D RSAD2 LAMB2 PLEKHA6 APOBEC3B	1.61e-06	184	48	5	2e0c9a2c40c892a2d435eafb31f1f838de9baf15
ToppCell	PBMC-Mild-Myeloid-cDC-cDC-cDC_9\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	LAMB2 PADI6 PLEKHA6 APOBEC3B	9.13e-06	122	48	4	7dabf8b4c34a3714f45c3a99c1aa159e2d0b7e9c
ToppCell	PBMC-Mild-Myeloid-cDC-cDC-cDC_9\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	LAMB2 PADI6 PLEKHA6 APOBEC3B	9.13e-06	122	48	4	489a01c71882be5a6d71a19d06574698988c20f6
ToppCell	droplet-Large_Intestine-COLON:P+D-30m-Epithelial-Enterocyte\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DPEP1 AQP8 ENTPD8 SLC35F5	3.44e-05	171	48	4	b0d616699e2110ffd6cf1868ed1f1a29f824e1fc
ToppCell	droplet-Large_Intestine-COLON:P+D-30m-Epithelial-enterocyte_of_epithelium_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DPEP1 AQP8 ENTPD8 SLC35F5	3.44e-05	171	48	4	e7dbee63cc39230aa12e7868ec78a129160c0d22
ToppCell	facs-Skin-Anagen-3m-Epithelial-epidermal_cell\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCC4 PLEKHA6 TMEM125 TLCD3A	4.11e-05	179	48	4	4a072526c3a524a7aed99bdb32a07a1ce1f48972
ToppCell	TCGA-Head_and_Esophagus-Primary_Tumor-Head_and_Neck_Carcinoma-Squamous_Cell_Carcinoma-4\|TCGA-Head_and_Esophagus / Sample_Type by Project: Shred V9	SART3 IL17REL TLR1 GRM1	4.20e-05	180	48	4	886ebaf9cf8992e8dd13fca799a1d1a2a9ce73d8
ToppCell	facs-Liver-Hepatocytes-24m-Epithelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACAD10 AQP8 ABCC2 ENTPD8	4.39e-05	182	48	4	770ce9f3f4538d0181a0181543841bc964c68274
ToppCell	facs-Liver-Hepatocytes-24m-Epithelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACAD10 AQP8 ABCC2 ENTPD8	4.39e-05	182	48	4	77ab860e2add49dad0c1ffbfc64278ad499dfbd5
ToppCell	facs-Liver-Hepatocytes-24m-Epithelial-hepatocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACAD10 AQP8 ABCC2 ENTPD8	4.39e-05	182	48	4	4921c7d5687cc79f896b39753bb621d7e3d2972f
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC6A5 CACNA1G PLEKHA6 GRM1	4.98e-05	188	48	4	1efbc99bcd6542e5d9fa91edb7c4295167914786
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_B1\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	SART3 APOBEC3D LAMB2 SLC35F5	5.29e-05	191	48	4	39ef8e1d7cc3ebb11717e8a55501515e3b72b177
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DPEP1 ABCC4 PLEKHA6 ABCC2	5.29e-05	191	48	4	3c464645d0e7e423f791bd63bf5bcf11f6b590d3
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DPEP1 ABCC4 PLEKHA6 ABCC2	5.29e-05	191	48	4	1c1d13144259b998d4a0e85142f7afef2ef1e63f
ToppCell	medial-2-Hematologic-Intermediate_Monocyte\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SLC24A4 TLR1 SMAP2 APOBEC3B	6.08e-05	198	48	4	432a26ace5b486695c9a933c0d44b73305b01ded
ToppCell	medial-Hematologic-Intermediate_Monocyte\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SLC24A4 TLR1 SMAP2 APOBEC3B	6.08e-05	198	48	4	dbd7869483c5a67944cb94ced0ee2c7b999adc2e
ToppCell	medial-Hematologic-Intermediate_Monocyte-2\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SLC24A4 TLR1 SMAP2 APOBEC3B	6.08e-05	198	48	4	8f64bb5cd8c3e2d5ef651821b0d59f67d1ca1a12
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW19-Neuroepithelial-Proteoglycan-expressing_cell\|GW19 / Sample Type, Dataset, Time_group, and Cell type.	RHBDF1 AVPR1A LAMB2 TLR6	6.33e-05	200	48	4	aafe594c88710f8c53d59667cdac5035e08f5511
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW19-Neuroepithelial\|GW19 / Sample Type, Dataset, Time_group, and Cell type.	RHBDF1 AVPR1A LAMB2 TLR6	6.33e-05	200	48	4	a6f0f5f644b7262878b0b9d4d90ee407c4124dd9
Drug	estradiol-17 beta-glucuronide	ABCC4 AQP8 ABCC2	1.16e-05	22	46	3	ctd:C025483
Drug	S-(2,4-dinitrophenyl)glutathione	ABCC4 ABCC2	1.20e-05	3	46	2	ctd:C030190
Disease	aspergillosis (is_implicated_in)	TLR1 TLR6	6.62e-05	8	46	2	DOID:13564 (is_implicated_in)
Disease	glycochenodeoxycholate glucuronide (1) measurement	CACNA1G ABCC2	1.83e-04	13	46	2	EFO_0800474
Disease	Drug toxicity	ABCC4 TLR1 ABCC2	3.09e-04	84	46	3	C0013221
Disease	Adverse reaction to drug	ABCC4 TLR1 ABCC2	3.09e-04	84	46	3	C0041755
Disease	perinatal necrotizing enterocolitis (biomarker_via_orthology)	TLR1 TLR6	3.19e-04	17	46	2	DOID:8677 (biomarker_via_orthology)
Disease	tuberculosis (is_implicated_in)	TLR1 TLR6	8.76e-04	28	46	2	DOID:399 (is_implicated_in)
Disease	Ataxia, Spinocerebellar	CACNA1G GRM1	1.29e-03	34	46	2	C0087012
Disease	Spinocerebellar Ataxia Type 2	CACNA1G GRM1	1.29e-03	34	46	2	C0752121
Disease	Spinocerebellar Ataxia Type 1	CACNA1G GRM1	1.29e-03	34	46	2	C0752120
Disease	Spinocerebellar Ataxia Type 5	CACNA1G GRM1	1.29e-03	34	46	2	C0752123
Disease	Spinocerebellar Ataxia Type 7	CACNA1G GRM1	1.29e-03	34	46	2	C0752125
Disease	Spinocerebellar Ataxia Type 6 (disorder)	CACNA1G GRM1	1.29e-03	34	46	2	C0752124
Disease	Spinocerebellar Ataxia Type 4	CACNA1G GRM1	1.37e-03	35	46	2	C0752122

Protein segments in the cluster

Peptide	Gene	Start	Entry
RRFQITWFVSWNPCL	APOBEC3D	96	Q96AK3
QIYRVTWFISWSPCF	APOBEC3B	271	Q9UH17
RQFLFHWTVNWRFLP	ALG3	266	Q92685
CSQSWAQWKLWRQRP	C2orf27A	106	P0DPF5
CFQSPRLQWVWRTAF	ACAD10	6	Q6JQN1
WRVSWYERFVQPCLV	AQP8	26	O94778
CVQAFRARNWWVASV	QDPR	26	P09417
FAGQVVRLTWWAVCR	SLC24A4	191	Q8NFF2
ACANIRRVPFAFKWW	PADI6	676	Q6TGC4
TSWGSWVRCPFEQRR	IL17REL	276	Q6ZVW7
STVNATIWEFCQRPW	ENTPD8	371	Q5MY95
RGAFVQQLWDFCVRW	DUOX2	726	Q9NRD8
ACWSDTLQRWFFLPR	CANT1	286	Q8WVQ1
NLRPWWQNESLAAFR	ECE2	666	P0DPD6
VVTSFAPQRRAAWWQ	LAMB2	111	P55268
CVFSWITSNRWLAIR	ABCC2	1196	Q92887
RHCTQAWAIRINPWV	NPIPB15	411	A6NHN6
ANLCSRVFFWWLNPL	ABCC4	16	O15439
RSWCLRTVCNPWFER	CACNA1G	71	O43497
WMCTRVWPSLQDRFS	HAUS7	71	Q99871
RNWAERWFQLQPSCL	DEF6	231	Q9H4E7
NPWLCNCEILYFRRW	GP1BA	221	P07359
PWFPEFWQHRFQCRL	GRM1	366	Q13255
WLWPLVAVCTADFFR	DPEP1	6	P16444
AIRNCPWTVALWSRY	SART3	371	Q15020
WLLSQACFNFPFWQR	NYNRIN	381	Q9P2P1
RIAFWLQWFNSFVNP	HRH4	341	Q9H3N8
RRIWNNVTRWFVTCV	VARS1	181	P26640
LGFIIWKPWRQQCTR	SLC35F5	116	Q8WV83
RSLVPLFCWLRATFW	RSAD2	26	Q8WXG1
FQPNIFWKVCWAFVT	SLC6A5	671	Q9Y345
TWLRSPVQNFCYIFW	FER1L5	1941	A0AVI2
CLSRFLGWWFRQPVL	MRPL45	11	Q9BRJ2
QSWQILARPWRAFFK	RHBDF1	736	Q96CC6
PSSVRFTWEQAFLRW	SMARCAL1	486	Q9NZC9
VIWRFRPNTRELWCY	MYCBP2	1136	O75592
FLLNCFVRSPSWQHW	OR56A3	16	Q8NH54
LPWYLRMVCQWTQTR	TLR1	606	Q15399
SFCPLSLWRWQLYAA	CLPTM1	306	O96005
QQLIFPAEARWCFSW	C10orf126	96	Q8N4M7
QWNKRWFVLVDRCLF	PLEKHA6	76	Q9Y2H5
PRWASWNIGVFICIR	SMAP2	36	Q8WU79
FALCTWALRRSQPGW	TLCD3A	16	Q8TBR7
PRWASWNIGVFICIR	SMAP1	41	Q8IYB5
TTWKCLVRVFQFLWP	TLR6	261	Q9Y2C9
LPWYLRMVCQWTQTR	TLR6	611	Q9Y2C9
RDCWATFIQPWGSRA	AVPR1A	201	P37288
LLVCQWSQWKYRPTR	USP17L15	526	C9J2P7
WWSQQPRRSALCFVV	TMEM125	26	Q96AQ2
IWACLPLRWQQAQAR	UHRF1BP1	726	Q6BDS2
WRFQLWFLGLTCPER	TMEM249	16	Q2WGJ8
PACWLWDFLRRSQQA	NADSYN1	336	Q6IA69