Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
MousePheno	increased interleukin-10 secretion	MARCHF7 PILRB PILRA	2.91e-05	34	25	3	MP:0008660
MousePheno	abnormal hepatic cord morphology	PILRB PILRA	4.59e-05	6	25	2	MP:0012246
MousePheno	decreased susceptibility to infection induced morbidity/mortality	USP49 RHBDF2 PILRB PILRA	5.68e-05	120	25	4	MP:0009786
MousePheno	decreased circulating tumor necrosis factor level	RHBDF2 PILRB PILRA	1.32e-04	56	25	3	MP:0008554
MousePheno	abnormal interleukin-10 secretion	MARCHF7 PILRB PILRA	2.56e-04	70	25	3	MP:0008659
MousePheno	increased interferon level	USP49 PILRB PILRA	2.67e-04	71	25	3	MP:0014435
MousePheno	increased cytokine level	USP49 PILRB PILRA	3.13e-04	75	25	3	MP:0014433
MousePheno	decreased circulating VLDL triglyceride level	GPAM ANGPTL8	5.15e-04	19	25	2	MP:0003976
Pubmed	Modulation of paired immunoglobulin-like type 2 receptor signaling alters the host response to Staphylococcus aureus-induced pneumonia.	PILRB PILRA	1.49e-06	2	43	2	20065029
Pubmed	The Ig-like v-type domain of paired Ig-like type 2 receptor alpha is critical for herpes simplex virus type 1-mediated membrane fusion.	PILRB PILRA	1.49e-06	2	43	2	20573830
Pubmed	A single-amino-acid substitution in herpes simplex virus 1 envelope glycoprotein B at a site required for binding to the paired immunoglobulin-like type 2 receptor alpha (PILRalpha) abrogates PILRalpha-dependent viral entry and reduces pathogenesis.	PILRB PILRA	1.49e-06	2	43	2	20686018
Pubmed	Monocyte infiltration into obese and fibrilized tissues is regulated by PILRα.	PILRB PILRA	1.49e-06	2	43	2	26840635
Pubmed	PILRα and PILRβ have a siglec fold and provide the basis of binding to sialic acid.	PILRB PILRA	1.49e-06	2	43	2	24843130
Pubmed	PILRα negatively regulates mouse inflammatory arthritis.	PILRB PILRA	1.49e-06	2	43	2	24935926
Pubmed	Neutrophil infiltration during inflammation is regulated by PILRα via modulation of integrin activation.	PILRB PILRA	1.49e-06	2	43	2	23142774
Pubmed	Blood flow guides sequential support of neutrophil arrest and diapedesis by PILR-β1 and PILR-α.	PILRB PILRA	4.48e-06	3	43	2	31385804
Pubmed	The CD8α-PILRα interaction maintains CD8+ T cell quiescence.	PILRB PILRA	4.48e-06	3	43	2	35617401
Pubmed	The myeloid receptor PILRβ mediates the balance of inflammatory responses through regulation of IL-27 production.	PILRB PILRA	4.48e-06	3	43	2	22479310
Pubmed	Counter-regulation of the ligand-receptor pair Leda-1/Pianp and Pilrα during the LPS-mediated immune response of murine macrophages.	PILRB PILRA	4.48e-06	3	43	2	26188512
Pubmed	PANP is a novel O-glycosylated PILRα ligand expressed in neural tissues.	PILRB PILRA	4.48e-06	3	43	2	21241660
Pubmed	Negative regulation of DSS-induced experimental colitis by PILRα.	PILRB PILRA	4.48e-06	3	43	2	25710489
Pubmed	Activation of natural killer cells and dendritic cells upon recognition of a novel CD99-like ligand by paired immunoglobulin-like type 2 receptor.	PILRB PILRA	8.94e-06	4	43	2	14970179
Pubmed	Evolutionarily conserved paired immunoglobulin-like receptor α (PILRα) domain mediates its interaction with diverse sialylated ligands.	PILRB PILRA	8.94e-06	4	43	2	22396535
Pubmed	FDF03, a novel inhibitory receptor of the immunoglobulin superfamily, is expressed by human dendritic and myeloid cells.	PILRB PILRA	1.49e-05	5	43	2	10903717
Pubmed	Comparative analysis of the paired immunoglobulin-like receptor (PILR) locus in six mammalian genomes: duplication, conversion, and the birth of new genes.	PILRB PILRA	1.49e-05	5	43	2	16926269
Pubmed	PILRalpha, a novel immunoreceptor tyrosine-based inhibitory motif-bearing protein, recruits SHP-1 upon tyrosine phosphorylation and is paired with the truncated counterpart PILRbeta.	PILRB PILRA	3.12e-05	7	43	2	10660620
Pubmed	Posttranslational proteolytic processing of Leda-1/Pianp involves cleavage by MMPs, ADAM10/17 and gamma-secretase.	PILRB PILRA	4.16e-05	8	43	2	27349870
Pubmed	An essential role of sialylated O-linked sugar chains in the recognition of mouse CD99 by paired Ig-like type 2 receptor (PILR).	PILRB PILRA	4.16e-05	8	43	2	18209065
Pubmed	Inhibitory immunoglobulin-like receptors LILRB and PIR-B negatively regulate osteoclast development.	PILRB PILRA	6.68e-05	10	43	2	18802077
Pubmed	Epithelial colonization by gut dendritic cells promotes their functional diversification.	PILRB PILRA	6.68e-05	10	43	2	34910930
Pubmed	Genetic association analysis of 13 nuclear-encoded mitochondrial candidate genes with type II diabetes mellitus: the DAMAGE study.	GPAM MTIF2	1.15e-04	13	43	2	19209188
Pubmed	Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters.	ZNF227 ZNF284	2.80e-04	20	43	2	12743021
Pubmed	Large-scale cDNA transfection screening for genes related to cancer development and progression.	ARRDC2 PILRB RBM23	3.85e-04	114	43	3	15498874
Pubmed	Biological, clinical and population relevance of 95 loci for blood lipids.	OSBPL7 GPAM ANGPTL8	7.91e-04	146	43	3	20686565
Disease	telomere length	ILDR1 ARRDC2 DCAF4 ANKDD1A	9.23e-04	313	41	4	EFO_0004505
Disease	ovarian carcinoma	WSCD1 GPAM DLC1 PKD1L1	1.01e-03	321	41	4	EFO_0001075
Disease	prostate carcinoma, type 2 diabetes mellitus	OSBPL7 ZBTB38	3.07e-03	59	41	2	EFO_0001663, MONDO_0005148
Disease	chronic kidney disease	DCAF4 MYO19 FOXB2	4.25e-03	235	41	3	EFO_0003884
Disease	childhood trauma measurement, alcohol consumption measurement	WSCD1 MARCHF7	4.41e-03	71	41	2	EFO_0007878, EFO_0007979

Protein segments in the cluster

Peptide	Gene	Start	Entry
WQSRRRHGRRSHQQN	DCAF4	6	Q8WV16
WHVRRRQEKQRGLHS	ACVRL1	141	P37023
RHWRAQLEVQASQHR	CLIP2	701	Q9UDT6
HILWALTGHVQRQRR	ANGPTL8	161	Q6UXH0
LLTWQARQRTRRHLH	ADAM8	271	P78325
ALRLRARGRAHVHWT	ARRDC2	46	Q8TBH0
RQCRHRSRSWDRRHG	RBM23	96	Q86U06
RHGQIRVFNHSRDRW	INO80	846	Q9ULG1
VQSFIGNLWHRRHRE	DGKK	1241	Q5KSL6
REHTQRWQNSLRHNL	FOXB2	51	Q5VYV0
QRRALRQWRHGFSSA	MTIF2	26	P46199
RCIQGGWRRHRHREQ	MYO19	766	Q96H55
HWRHRRDFLLRNAGD	CDKN2AIP	31	Q9NXV6
WFLLRHVTQRGRHQD	DCAF8L2	581	P0C7V8
ERQPQSWRAHRRGSH	ILDR1	486	Q86SU0
NAWHDVRVTRNLRQH	NRXN2	371	Q9P2S2
APRSQHWLHRDLRVR	GPKOW	351	Q92917
DVRISWRRGHFHRQS	PILRA	66	Q9UKJ1
LRRRWGLSSLSHNHS	MARCHF7	351	Q9H992
VLAARQQARHLRWAH	PKD1L1	2246	Q8TDX9
QSWVAQLRAHRLAHR	OSBPL7	131	Q9BZF2
GRWQRNALHSQAHRG	RTL1	1171	A6NKG5
TWIAHSRHGQTRDRV	POGZ	851	Q7Z3K3
ETHTRHRGWLARRLS	GPAM	96	Q9HCL2
SLTRSNRHRLRWHSF	DLC1	991	Q96QB1
NRHRLRWHSFQSSHR	DLC1	996	Q96QB1
ARAWRRMSRSFQIHH	HTR3D	171	Q70Z44
FQIHHRTSFRTRREW	HTR3D	181	Q70Z44
TRARNHVGRVALHWA	ANKDD1A	41	Q495B1
SSEARASLHQWHRRR	RINL	521	Q6ZS11
WFHNGHRIQSSDDRR	SPEG	1221	Q15772
HHTIGGSRRAAWRRR	RPL15	181	P61313
LHLKRFRWSGRNHRE	USP49	551	Q70CQ1
SRGGHHCARRWLRRV	nan	26	Q5XG85
NVRISWRRGHFHGQS	PILRB	66	Q9UKJ0
SRGGHHCARRWLRRV	nan	26	Q5VV11
RRRHLSERLSWHQDQ	ZSWIM2	11	Q8NEG5
RQAQLQRHRVRWLHG	TEX13A	81	Q9BXU3
FRWGSDLARHQRTHT	ZNF213	326	O14771
WSVNLRVHQRVHRGE	ZNF227	391	Q86WZ6
VARSHVQWLRHRATQ	SNAPC4	711	Q5SXM2
HRATQSGQRRWRHAL	SNAPC4	721	Q5SXM2
SGQRRWRHALHRRLL	SNAPC4	726	Q5SXM2
NRHRSWDQGRRSQSR	ZRSR2P1	431	Q15695
TLSSLRRHANVHSWR	ZBTB38	471	Q8NAP3
NSELRQLRRRWFHHF	WSCD1	106	Q658N2
SHRLHSNRQTWRWHQ	PRR30	166	Q53SZ7
RQQWQRRSLHHCSMR	RHBDF2	136	Q6PJF5
RWSSCLSRHQRVHNG	ZNF284	381	Q2VY69