Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	PREB ZNF28 ALX1 VEZF1 NKX2-1 ZC3H8 ZNF790 ZNF770 ZFHX3 ZNF227 RFX3 DMBX1 ZNF829 SMAD9 PROX1	2.17e-06	1459	51	15	GO:0000977
GeneOntologyMolecularFunction	microfilament motor activity	MYH1 MYH2 MYH4 MYH8	2.61e-06	38	51	4	GO:0000146
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF28 ALX1 VEZF1 NKX2-1 ZC3H8 ZNF790 ZNF770 ZFHX3 ZNF227 RFX3 DMBX1 ZNF829 SMAD9 PROX1	7.90e-06	1412	51	14	GO:0000981
GeneOntologyMolecularFunction	cytoskeletal motor activity	MYH1 MYH2 MYH4 MYH8	2.34e-04	118	51	4	GO:0003774
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	PREB ZNF28 NKX2-1 ZNF790 ZNF770 ZFHX3 ZNF227 RFX3 ZNF829 SMAD9 PROX1	2.48e-04	1244	51	11	GO:0000978
GeneOntologyMolecularFunction	actin filament binding	MYH1 MYH2 MYH4 MYH8 SPTBN1	2.79e-04	227	51	5	GO:0051015
GeneOntologyMolecularFunction	calmodulin binding	MYH1 MYH2 MYH4 MYH8 SPTBN1	2.96e-04	230	51	5	GO:0005516
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	PREB ZNF28 NKX2-1 ZNF790 ZNF770 ZFHX3 ZNF227 RFX3 ZNF829 SMAD9 PROX1	2.99e-04	1271	51	11	GO:0000987
GeneOntologyMolecularFunction	poly(A) RNA polymerase activity	TENT4B TENT2	4.15e-04	12	51	2	GO:1990817
GeneOntologyMolecularFunction	intronic transcription regulatory region sequence-specific DNA binding	NKX2-1 ZC3H8	8.49e-04	17	51	2	GO:0001161
GeneOntologyMolecularFunction	DNA-binding transcription repressor activity, RNA polymerase II-specific	ZNF28 ZC3H8 ZFHX3 DMBX1 PROX1	1.32e-03	320	51	5	GO:0001227
GeneOntologyMolecularFunction	DNA-binding transcription repressor activity	ZNF28 ZC3H8 ZFHX3 DMBX1 PROX1	1.43e-03	326	51	5	GO:0001217
GeneOntologyMolecularFunction	adenylyltransferase activity	TENT4B TENT2	2.84e-03	31	51	2	GO:0070566
GeneOntologyBiologicalProcess	positive regulation of transcription by RNA polymerase II	PREB RGMA ALX1 VEZF1 NKX2-1 PAXIP1 ZNF770 ZFHX3 ATM ZNF227 ZMIZ1 RFX3 SMAD9 PROX1	3.51e-06	1390	50	14	GO:0045944
GeneOntologyBiologicalProcess	histone mRNA catabolic process	TENT4B ATM TENT2	5.97e-06	15	50	3	GO:0071044
GeneOntologyBiologicalProcess	muscle filament sliding	MYH2 MYH4 MYH8	5.97e-06	15	50	3	GO:0030049
GeneOntologyBiologicalProcess	actin-myosin filament sliding	MYH2 MYH4 MYH8	1.07e-05	18	50	3	GO:0033275
GeneOntologyBiologicalProcess	histone mRNA metabolic process	TENT4B ATM TENT2	2.62e-05	24	50	3	GO:0008334
GeneOntologyCellularComponent	muscle myosin complex	MYH1 MYH2 MYH4 MYH8	6.06e-08	16	52	4	GO:0005859
GeneOntologyCellularComponent	myosin complex	MYH1 MYH2 MYH4 MYH8 BMF	3.54e-07	59	52	5	GO:0016459
GeneOntologyCellularComponent	myosin filament	MYH1 MYH2 MYH4 MYH8	4.14e-07	25	52	4	GO:0032982
GeneOntologyCellularComponent	myosin II complex	MYH1 MYH2 MYH4 MYH8	6.67e-07	28	52	4	GO:0016460
GeneOntologyCellularComponent	A band	MYH1 MYH2 SPTBN1	2.94e-04	52	52	3	GO:0031672
GeneOntologyCellularComponent	sarcomere	MYH1 MYH2 MYH4 MYH8 SPTBN1	3.79e-04	249	52	5	GO:0030017
GeneOntologyCellularComponent	myofibril	MYH1 MYH2 MYH4 MYH8 SPTBN1	5.76e-04	273	52	5	GO:0030016
GeneOntologyCellularComponent	contractile muscle fiber	MYH1 MYH2 MYH4 MYH8 SPTBN1	7.57e-04	290	52	5	GO:0043292
GeneOntologyCellularComponent	DNA repair complex	ATM PHF21A	1.48e-03	23	52	2	GO:1990391
Domain	Myosin_N	MYH1 MYH2 MYH4 MYH8	7.13e-08	15	52	4	IPR004009
Domain	Myosin_N	MYH1 MYH2 MYH4 MYH8	7.13e-08	15	52	4	PF02736
Domain	Myosin_tail_1	MYH1 MYH2 MYH4 MYH8	1.59e-07	18	52	4	PF01576
Domain	Myosin_tail	MYH1 MYH2 MYH4 MYH8	1.59e-07	18	52	4	IPR002928
Domain	Myosin-like_IQ_dom	MYH1 MYH2 MYH4 MYH8	2.01e-07	19	52	4	IPR027401
Domain	-	MYH1 MYH2 MYH4 MYH8	2.01e-07	19	52	4	4.10.270.10
Domain	MYOSIN_MOTOR	MYH1 MYH2 MYH4 MYH8	3.68e-06	38	52	4	PS51456
Domain	Myosin_head	MYH1 MYH2 MYH4 MYH8	3.68e-06	38	52	4	PF00063
Domain	Myosin_head_motor_dom	MYH1 MYH2 MYH4 MYH8	3.68e-06	38	52	4	IPR001609
Domain	MYSc	MYH1 MYH2 MYH4 MYH8	3.68e-06	38	52	4	SM00242
Domain	IQ	MYH1 MYH2 MYH4 MYH8	4.52e-05	71	52	4	PF00612
Domain	IQ	MYH1 MYH2 MYH4 MYH8	7.59e-05	81	52	4	SM00015
Domain	IQ_motif_EF-hand-BS	MYH1 MYH2 MYH4 MYH8	1.14e-04	90	52	4	IPR000048
Domain	IQ	MYH1 MYH2 MYH4 MYH8	1.30e-04	93	52	4	PS50096
Domain	PAP_assoc	TENT4B TENT2	1.58e-04	7	52	2	IPR002058
Domain	PAP_assoc	TENT4B TENT2	1.58e-04	7	52	2	PF03828
Domain	OAR	ALX1 DMBX1	7.80e-04	15	52	2	PF03826
Domain	OAR	ALX1 DMBX1	8.90e-04	16	52	2	PS50803
Domain	OAR_dom	ALX1 DMBX1	8.90e-04	16	52	2	IPR003654
Domain	WD_REPEATS_1	PREB SEH1L CFAP251 SEC31A EIF2A	1.03e-03	278	52	5	PS00678
Domain	WD_REPEATS_2	PREB SEH1L CFAP251 SEC31A EIF2A	1.05e-03	279	52	5	PS50082
Domain	WD_REPEATS_REGION	PREB SEH1L CFAP251 SEC31A EIF2A	1.05e-03	279	52	5	PS50294
Domain	WD40_repeat_dom	PREB SEH1L CFAP251 SEC31A EIF2A	1.39e-03	297	52	5	IPR017986
Domain	Homeobox_CS	ALX1 NKX2-1 ZFHX3 DMBX1	1.78e-03	186	52	4	IPR017970
Domain	Homeodomain-like	ALX1 NKX2-1 ZFHX3 DMBX1 PROX1	2.26e-03	332	52	5	IPR009057
Domain	-	PREB SEH1L CFAP251 SEC31A EIF2A	2.29e-03	333	52	5	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	PREB SEH1L CFAP251 SEC31A EIF2A	2.35e-03	335	52	5	IPR015943
Domain	-	ZNF28 VEZF1 ZNF790 ZNF770 ZFHX3 ZNF227 ZNF829	2.63e-03	679	52	7	3.30.160.60
Domain	zf-C2H2	ZNF28 VEZF1 ZNF790 ZNF770 ZFHX3 ZNF227 ZNF829	2.94e-03	693	52	7	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF28 VEZF1 ZNF790 ZNF770 ZFHX3 ZNF227 ZNF829	2.97e-03	694	52	7	IPR013087
Domain	Homeobox	ALX1 NKX2-1 ZFHX3 DMBX1	4.06e-03	234	52	4	PF00046
Domain	HOMEOBOX_1	ALX1 NKX2-1 ZFHX3 DMBX1	4.18e-03	236	52	4	PS00027
Domain	HOX	ALX1 NKX2-1 ZFHX3 DMBX1	4.25e-03	237	52	4	SM00389
Domain	Homeobox_dom	ALX1 NKX2-1 ZFHX3 DMBX1	4.38e-03	239	52	4	IPR001356
Domain	HOMEOBOX_2	ALX1 NKX2-1 ZFHX3 DMBX1	4.38e-03	239	52	4	PS50071
Domain	ZINC_FINGER_C2H2_2	ZNF28 VEZF1 ZNF790 ZNF770 ZFHX3 ZNF227 ZNF829	5.42e-03	775	52	7	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF28 VEZF1 ZNF790 ZNF770 ZFHX3 ZNF227 ZNF829	5.50e-03	777	52	7	PS00028
Domain	WD40	PREB SEH1L CFAP251 SEC31A	5.81e-03	259	52	4	PF00400
Domain	Znf_C2H2-like	ZNF28 VEZF1 ZNF790 ZNF770 ZFHX3 ZNF227 ZNF829	6.26e-03	796	52	7	IPR015880
Domain	WD40	PREB SEH1L CFAP251 SEC31A	6.54e-03	268	52	4	SM00320
Domain	Znf_C2H2	ZNF28 VEZF1 ZNF790 ZNF770 ZFHX3 ZNF227 ZNF829	6.65e-03	805	52	7	IPR007087
Domain	ZnF_C2H2	ZNF28 VEZF1 ZNF790 ZNF770 ZFHX3 ZNF227 ZNF829	6.78e-03	808	52	7	SM00355
Domain	WD40_repeat	PREB SEH1L CFAP251 SEC31A	6.89e-03	272	52	4	IPR001680
Domain	-	ALX1 NKX2-1 ZFHX3 DMBX1	7.90e-03	283	52	4	1.10.10.60
Domain	Quinoprotein_ADH-like_supfam	PREB CFAP251	9.57e-03	53	52	2	IPR011047
Pathway	KEGG_VIRAL_MYOCARDITIS	MYH1 MYH2 MYH4 MYH8	3.25e-05	70	37	4	M12294
Pathway	WP_SMC1SMC3_ROLE_IN_DNA_DAMAGE_CORNELIA_DE_LANGE_SYNDROME	PAXIP1 ATM	3.63e-04	11	37	2	M42562
Pathway	KEGG_TIGHT_JUNCTION	MYH1 MYH2 MYH4 MYH8	3.82e-04	132	37	4	M11355
Pathway	KEGG_MEDICUS_REFERENCE_COPII_VESICLE_FORMATION	PREB SEC31A	4.35e-04	12	37	2	M47770
Pubmed	Sequential accumulation of mRNAs encoding different myosin heavy chain isoforms during skeletal muscle development in vivo detected with a recombinant plasmid identified as coding for an adult fast myosin heavy chain from mouse skeletal muscle.	MYH1 MYH2 MYH4 MYH8	2.22e-11	5	52	4	6196357
Pubmed	Developmental pattern of mouse skeletal myosin heavy chain gene transcripts in vivo and in vitro.	MYH1 MYH2 MYH4 MYH8	2.22e-11	5	52	4	3829126
Pubmed	Myosin heavy chain isoforms of the murine masseter muscle during pre- and post-natal development.	MYH1 MYH2 MYH4 MYH8	2.22e-11	5	52	4	12919077
Pubmed	Distinct myogenic programs of embryonic and fetal mouse muscle cells: expression of the perinatal myosin heavy chain isoform in vitro.	MYH1 MYH2 MYH4 MYH8	6.65e-11	6	52	4	1728586
Pubmed	Organization of human and mouse skeletal myosin heavy chain gene clusters is highly conserved.	MYH1 MYH2 MYH4 MYH8	6.65e-11	6	52	4	10077619
Pubmed	Spatial and temporal changes in myosin heavy chain gene expression in skeletal muscle development.	MYH1 MYH2 MYH4 MYH8	6.65e-11	6	52	4	10588881
Pubmed	A fast Myosin super enhancer dictates muscle fiber phenotype through competitive interactions with Myosin genes.	MYH1 MYH2 MYH4 MYH8	1.55e-10	7	52	4	35210422
Pubmed	Diversity in transcriptional start site selection and alternative splicing affects the 5'-UTR of mouse striated muscle myosin transcripts.	MYH1 MYH2 MYH4 MYH8	1.55e-10	7	52	4	16819597
Pubmed	Modulation of contractile protein gene expression in fetal murine crural muscles: emergence of muscle diversity.	MYH1 MYH2 MYH4 MYH8	1.45e-09	11	52	4	8136524
Pubmed	Contractile protein gene expression in primary myotubes of embryonic mouse hindlimb muscles.	MYH1 MYH2 MYH4 MYH8	3.14e-09	13	52	4	8404542
Pubmed	Transition of myosin heavy chain isoforms in human laryngeal abductors following denervation.	MYH1 MYH2 MYH4	3.15e-09	3	52	3	26059207
Pubmed	Loss of Prox1 in striated muscle causes slow to fast skeletal muscle fiber conversion and dilated cardiomyopathy.	MYH1 MYH2 MYH4 PROX1	4.40e-09	14	52	4	24938781
Pubmed	Defective excitation-contraction coupling is partially responsible for impaired contractility in hindlimb muscles of Stac3 knockout mice.	MYH1 MYH2 MYH4 MYH8	4.40e-09	14	52	4	27184118
Pubmed	Comparative sequence analysis of the complete human sarcomeric myosin heavy chain family: implications for functional diversity.	MYH1 MYH2 MYH4	1.26e-08	4	52	3	10388558
Pubmed	Evaluation of embryonic and perinatal myosin gene mutations and the etiology of congenital idiopathic clubfoot.	MYH1 MYH2 MYH8	1.26e-08	4	52	3	20357587
Pubmed	A human YAC transgene rescues craniofacial and neural tube development in PDGFRalpha knockout mice and uncovers a role for PDGFRalpha in prenatal lung growth.	MYH1 MYH2 MYH4	1.26e-08	4	52	3	11023856
Pubmed	Three linked myosin heavy chain genes clustered within 370 kb of each other show independent transcriptional and post-transcriptional regulation during differentiation of a mouse muscle cell line.	MYH1 MYH4 MYH8	1.26e-08	4	52	3	1985022
Pubmed	Smooth muscle myosin light chain kinase expression in cardiac and skeletal muscle.	MYH1 MYH2 MYH4	1.26e-08	4	52	3	11029314
Pubmed	Modulation of skeletal muscle fiber type by mitogen-activated protein kinase signaling.	MYH1 MYH2 MYH4	1.26e-08	4	52	3	18417546
Pubmed	Detection of Gene and Protein Expression in Mouse Embryos and Tissue Sections.	MYH1 MYH2 MYH4	3.15e-08	5	52	3	30737693
Pubmed	A new role for the calcineurin/NFAT pathway in neonatal myosin heavy chain expression via the NFATc2/MyoD complex during mouse myogenesis.	MYH1 MYH2 MYH4 MYH8	3.19e-08	22	52	4	24301466
Pubmed	A hypoplastic model of skeletal muscle development displaying reduced foetal myoblast cell numbers, increased oxidative myofibres and improved specific tension capacity.	MYH1 MYH2 MYH4	6.28e-08	6	52	3	20417199
Pubmed	A role for Insulin-like growth factor 2 in specification of the fast skeletal muscle fibre.	MYH1 MYH2 MYH4	6.28e-08	6	52	3	17559643
Pubmed	ANKK1 is found in myogenic precursors and muscle fibers subtypes with glycolytic metabolism.	MYH1 MYH2 MYH4	1.10e-07	7	52	3	29758057
Pubmed	Genome-wide mapping of Sox6 binding sites in skeletal muscle reveals both direct and indirect regulation of muscle terminal differentiation by Sox6.	MYH1 MYH2 MYH4 PROX1	1.36e-07	31	52	4	21985497
Pubmed	Neuromuscular junction immaturity and muscle atrophy are hallmarks of the ColQ-deficient mouse, a model of congenital myasthenic syndrome with acetylcholinesterase deficiency.	MYH1 MYH2 MYH4	1.76e-07	8	52	3	26993635
Pubmed	Genes for skeletal muscle myosin heavy chains are clustered and are not located on the same mouse chromosome as a cardiac myosin heavy chain gene.	MYH1 MYH4 MYH8	1.76e-07	8	52	3	3864153
Pubmed	Cell lineage- and expression-based inference of the roles of forkhead box transcription factor Foxc2 in craniofacial development.	MYH1 MYH2 MYH4	1.76e-07	8	52	3	33667029
Pubmed	A Tcf4-positive mesodermal population provides a prepattern for vertebrate limb muscle patterning.	MYH1 MYH2 MYH4	1.76e-07	8	52	3	14667415
Pubmed	Myosin heavy chain-embryonic regulates skeletal muscle differentiation during mammalian development.	MYH1 MYH2 MYH4 MYH8	1.76e-07	33	52	4	32094117
Pubmed	GASP-2 overexpressing mice exhibit a hypermuscular phenotype with contrasting molecular effects compared to GASP-1 transgenics.	MYH1 MYH2 MYH4	2.63e-07	9	52	3	31960486
Pubmed	Temporal regulation of the Mediator complex during muscle proliferation, differentiation, regeneration, aging, and disease.	MYH1 MYH2 MYH4 MYH8	3.51e-07	39	52	4	38690566
Pubmed	During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation.	MYH1 MYH4 MYH8	3.75e-07	10	52	3	19506036
Pubmed	Acceleration of somitic myogenesis in embryos of myogenin promoter-MRF4 transgenic mice.	MYH1 MYH2 MYH8	3.75e-07	10	52	3	8950513
Pubmed	Extracellular matrix protein composition dynamically changes during murine forelimb development.	MYH1 MYH2 MYH4	5.16e-07	11	52	3	38303699
Pubmed	Deletion of the protein kinase A/protein kinase G target SMTNL1 promotes an exercise-adapted phenotype in vascular smooth muscle.	MYH1 MYH2 MYH4	5.16e-07	11	52	3	18310078
Pubmed	The histone code reader Spin1 controls skeletal muscle development.	MYH1 MYH2 MYH4	5.16e-07	11	52	3	29168801
Pubmed	Calcineurin is necessary for the maintenance but not embryonic development of slow muscle fibers.	MYH1 MYH2 MYH4	5.16e-07	11	52	3	16024798
Pubmed	HOXA5 plays tissue-specific roles in the developing respiratory system.	MYH1 MYH2 MYH4 MYH8	6.92e-07	46	52	4	28827394
Pubmed	The inhibition of differentiation caused by TGFbeta in fetal myoblasts is dependent upon selective expression of PKCtheta: a possible molecular basis for myoblast diversification during limb histogenesis.	MYH1 MYH2 MYH8	8.92e-07	13	52	3	8948582
Pubmed	Six1 homeoprotein drives myofiber type IIA specialization in soleus muscle.	MYH1 MYH2 MYH8 PROX1	9.72e-07	50	52	4	27597886
Pubmed	Myopathy associated LDB3 mutation causes Z-disc disassembly and protein aggregation through PKCα and TSC2-mTOR downregulation.	MYH1 MYH2 MYH4	1.13e-06	14	52	3	33742095
Pubmed	Six homeoproteins and a Iinc-RNA at the fast MYH locus lock fast myofiber terminal phenotype.	MYH1 MYH2 MYH4	1.42e-06	15	52	3	24852826
Pubmed	MusTRD can regulate postnatal fiber-specific expression.	MYH1 MYH2 MYH4	1.74e-06	16	52	3	16494860
Pubmed	A family of microRNAs encoded by myosin genes governs myosin expression and muscle performance.	MYH1 MYH2 MYH4	1.74e-06	16	52	3	19922871
Pubmed	Genesis of muscle fiber-type diversity during mouse embryogenesis relies on Six1 and Six4 gene expression.	MYH1 MYH2 MYH4 MYH8	1.78e-06	58	52	4	21884692
Pubmed	Slow and fast fiber isoform gene expression is systematically altered in skeletal muscle of the Sox6 mutant, p100H.	MYH2 MYH4 MYH8	2.11e-06	17	52	3	16124007
Pubmed	IKKα and alternative NF-κB regulate PGC-1β to promote oxidative muscle metabolism.	MYH1 MYH2 MYH4	2.11e-06	17	52	3	22351927
Pubmed	Myosin heavy chains IIa and IId are functionally distinct in the mouse.	MYH1 MYH2	2.19e-06	2	52	2	9585413
Pubmed	Analysis of mouse conceptuses with uniparental duplication/deficiency for distal chromosome 12: comparison with chromosome 12 uniparental disomy and implications for genomic imprinting.	MYH1 MYH2	2.19e-06	2	52	2	16575183
Pubmed	Five skeletal myosin heavy chain genes are organized as a multigene complex in the human genome.	MYH4 MYH8	2.19e-06	2	52	2	8518795
Pubmed	Type IIx myosin heavy chain transcripts are expressed in type IIb fibers of human skeletal muscle.	MYH1 MYH2	2.19e-06	2	52	2	7545970
Pubmed	Growth and muscle defects in mice lacking adult myosin heavy chain genes.	MYH1 MYH4	2.19e-06	2	52	2	9382868
Pubmed	Postnatal myosin heavy chain isoform expression in normal mice and mice null for IIb or IId myosin heavy chains.	MYH1 MYH4	2.19e-06	2	52	2	11150240
Pubmed	Myosin heavy chain composition of the human genioglossus muscle.	MYH1 MYH2	2.19e-06	2	52	2	22337492
Pubmed	Temporal spatial expression and function of non-muscle myosin II isoforms IIA and IIB in scar remodeling.	MYH2 MYH4	2.19e-06	2	52	2	21102503
Pubmed	Different pathways regulate expression of the skeletal myosin heavy chain genes.	MYH1 MYH2	2.19e-06	2	52	2	11551968
Pubmed	Skeletal muscle adaptations in response to voluntary wheel running in myosin heavy chain null mice.	MYH1 MYH4	2.19e-06	2	52	2	11744674
Pubmed	Neuron-specific antioxidant OXR1 extends survival of a mouse model of amyotrophic lateral sclerosis.	MYH1 MYH2 MYH4	2.53e-06	18	52	3	25753484
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	GGNBP2 VEZF1 NKX2-1 ZC3H8 ZNF790 ZFHX3 RFX3 DMBX1 PHF21A	2.84e-06	808	52	9	20412781
Pubmed	Simultaneous loss of skeletal muscle myosin heavy chain IIx and IIb causes severe skeletal muscle hypoplasia in postnatal mice.	MYH1 MYH4	6.57e-06	3	52	2	36515178
Pubmed	Structural and developmental analysis of two linked myosin heavy chain genes.	MYH1 MYH2	6.57e-06	3	52	2	1371481
Pubmed	Maximum velocity of shortening in relation to myosin isoform composition in single fibres from human skeletal muscles.	MYH2 MYH4	6.57e-06	3	52	2	8145163
Pubmed	Molecular determinants of force production in human skeletal muscle fibers: effects of myosin isoform expression and cross-sectional area.	MYH1 MYH2	6.57e-06	3	52	2	25567808
Pubmed	ZEB1 imposes a temporary stage-dependent inhibition of muscle gene expression and differentiation via CtBP-mediated transcriptional repression.	MYH2 MYH4	6.57e-06	3	52	2	23339872
Pubmed	The myosin alkali light chain proteins and their genes.	MYH2 MYH4	6.57e-06	3	52	2	3904738
Pubmed	The expression of myosin heavy chain (MHC) genes in human skeletal muscle is related to metabolic characteristics involved in the pathogenesis of type 2 diabetes.	MYH1 MYH2	6.57e-06	3	52	2	21470888
Pubmed	Specific isomyosin proportions in hyperexcitable and physiologically denervated mouse muscle.	MYH2 MYH4	6.57e-06	3	52	2	15013776
Pubmed	CircRFX3 Up-regulates Its Host Gene RFX3 to Facilitate Tumorigenesis and Progression of Glioma.	RFX3 PROX1	6.57e-06	3	52	2	35416616
Pubmed	Ectopic sonic hedgehog signaling impairs telencephalic dorsal midline development: implication for human holoprosencephaly.	NKX2-1 SMAD9 PROX1	7.08e-06	25	52	3	17468181
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	MYH1 MYH2 MYH4 MYH8 GGNBP2 VEZF1 SPTBN1 FAM98A ATM USPL1 DNAJB14	7.55e-06	1442	52	11	35575683
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	VEZF1 NKX2-1 ZC3H8 ZFHX3 DMBX1 PHF21A SMAD9 PROX1	9.78e-06	709	52	8	22988430
Pubmed	Synemin acts as a regulator of signalling molecules during skeletal muscle hypertrophy.	MYH2 MYH4 MYH8	1.01e-05	28	52	3	25179606
Pubmed	Human PTIP facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation.	PAXIP1 ATM	1.31e-05	4	52	2	15456759
Pubmed	Control of muscle formation by the fusogenic micropeptide myomixer.	MYH1 MYH2	1.31e-05	4	52	2	28386024
Pubmed	The ZFHX3 (ATBF1) transcription factor induces PDGFRB, which activates ATM in the cytoplasm to protect cerebellar neurons from oxidative stress.	ZFHX3 ATM	1.31e-05	4	52	2	20876357
Pubmed	Deficiency of Myo18B in mice results in embryonic lethality with cardiac myofibrillar aberrations.	MYH1 MYH2	1.31e-05	4	52	2	18761673
Pubmed	Human MYO18B, a novel unconventional myosin heavy chain expressed in striated muscles moves into the myonuclei upon differentiation.	MYH1 MYH4	1.31e-05	4	52	2	12547197
Pubmed	Autophagy controls neonatal myogenesis by regulating the GH-IGF1 system through a NFE2L2- and DDIT3-mediated mechanism.	MYH1 MYH2 MYH4	1.38e-05	31	52	3	30081710
Pubmed	HOXA5 Participates in Brown Adipose Tissue and Epaxial Skeletal Muscle Patterning and in Brown Adipocyte Differentiation.	MYH2 MYH4 MYH8	1.52e-05	32	52	3	33732701
Pubmed	Cullin-3-RING ubiquitin ligase activity is required for striated muscle function in mice.	MYH1 MYH2	2.19e-05	5	52	2	29653945
Pubmed	Multigene family for sarcomeric myosin heavy chain in mouse and human DNA: localization on a single chromosome.	MYH1 MYH2	2.19e-05	5	52	2	6879174
Pubmed	Sox6 is required for normal fiber type differentiation of fetal skeletal muscle in mice.	MYH1 MYH2	2.19e-05	5	52	2	17584907
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	SEH1L VEZF1 MYCBP2 ZC3H8 SPTBN1 INTS1 SEC31A ATM PROX1	2.92e-05	1082	52	9	38697112
Pubmed	Isolation and characterization of spheroid cells from human malignant melanoma cell line WM-266-4.	PROM1 PROX1	3.28e-05	6	52	2	19940551
Pubmed	TANGO1 recruits Sec16 to coordinately organize ER exit sites for efficient secretion.	PREB SEC31A	3.28e-05	6	52	2	28442536
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	MYCBP2 ZFHX3 ZMIZ1 AKAP1 PHF21A PROX1	3.71e-05	418	52	6	34709266
Pubmed	A hypomorphic myogenin allele reveals distinct myogenin expression levels required for viability, skeletal muscle development, and sternum formation.	MYH4 MYH8	4.58e-05	7	52	2	10075840
Pubmed	ATM-phosphorylated SPOP contributes to 53BP1 exclusion from chromatin during DNA replication.	PAXIP1 ATM	4.58e-05	7	52	2	34144977
Pubmed	Hox11-expressing interstitial cells contribute to adult skeletal muscle at homeostasis.	MYH1 MYH2	4.58e-05	7	52	2	36815629
Pubmed	The brain expressed x-linked gene 1 (Bex1) regulates myoblast fusion.	MYH1 MYH2	4.58e-05	7	52	2	26586200
Pubmed	Myomaker is a membrane activator of myoblast fusion and muscle formation.	MYH1 MYH2	4.58e-05	7	52	2	23868259
Pubmed	Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus.	ALX1 ZFHX3 DMBX1 PHF21A PROX1	4.63e-05	263	52	5	20932939
Pubmed	A census of human transcription factors: function, expression and evolution.	ZNF28 ALX1 NKX2-1 ZFHX3 RFX3 DMBX1 SMAD9 PROX1	5.70e-05	908	52	8	19274049
Pubmed	Long noncoding RNA lncMREF promotes myogenic differentiation and muscle regeneration by interacting with the Smarca5/p300 complex.	MYH1 MYH4	6.10e-05	8	52	2	36200826
Pubmed	A Hoxa13:Cre mouse strain for conditional gene manipulation in developing limb, hindgut, and urogenital system.	MYH1 MYH2	6.10e-05	8	52	2	25980463
Pubmed	Migration of oligodendrocyte progenitor cells is controlled by transforming growth factor β family proteins during corticogenesis.	SMAD9 PROX1	7.84e-05	9	52	2	25378163
Pubmed	The histone demethylase LSD1/KDM1A promotes the DNA damage response.	ATM PHF21A	7.84e-05	9	52	2	24217620
Pubmed	Dual functions of ASCIZ in the DNA base damage response and pulmonary organogenesis.	NKX2-1 ATM	7.84e-05	9	52	2	20975950
Pubmed	Transdifferentiation of esophageal smooth to skeletal muscle is myogenic bHLH factor-dependent.	MYH2 MYH8	7.84e-05	9	52	2	10725239
Interaction	RSPH6A interactions	MYH1 MYH2 MYH4 MYH8	1.59e-06	34	51	4	int:RSPH6A
Interaction	HDAC1 interactions	MYH1 MYH2 MYH4 MYH8 MYCBP2 NKX2-1 ZFHX3 ATM ZMIZ1 AKAP1 RFX3 PHF21A	1.55e-05	1108	51	12	int:HDAC1
Interaction	TSPAN33 interactions	MYH1 MYH2 MYH4 MYH8	2.20e-05	65	51	4	int:TSPAN33
Interaction	PRKAG2 interactions	MYH1 MYH2 MYH4 MYH8	2.63e-05	68	51	4	int:PRKAG2
Interaction	SLC39A3 interactions	MYH1 MYH2 MYH4 MYH8	2.95e-05	70	51	4	int:SLC39A3
Interaction	TLE3 interactions	MYH1 MYH2 MYH4 MYH8 VEZF1 ZFHX3 ZMIZ1	4.25e-05	376	51	7	int:TLE3
Interaction	FKBP6 interactions	MEI4 MYH1 MYH4 MYH8	6.63e-05	86	51	4	int:FKBP6
Interaction	STK3 interactions	MYH1 MYH2 MYH8 MYCBP2 SPTBN1	9.29e-05	181	51	5	int:STK3
Interaction	ASAH2 interactions	MYH1 MYH4	9.36e-05	6	51	2	int:ASAH2
Interaction	KRT40 interactions	MYH1 MYH2 MYH4 MYH8 VEZF1 ZFHX3 PHF21A	1.05e-04	434	51	7	int:KRT40
Interaction	ZSCAN5A interactions	MYH1 MYH4 MYH8	1.21e-04	38	51	3	int:ZSCAN5A
Interaction	ABTB2 interactions	MYH1 MYH2 MYH4 MYH8	1.24e-04	101	51	4	int:ABTB2
Interaction	E4F1 interactions	ZC3H8 ZNF770 ATM SMAD9	1.24e-04	101	51	4	int:E4F1
Interaction	MSX2 interactions	PREB VEZF1 SPTBN1 ZFHX3 FAM98A	1.32e-04	195	51	5	int:MSX2
Interaction	AURKC interactions	MYH1 MYH4 MYH8	1.75e-04	43	51	3	int:AURKC
Interaction	TBR1 interactions	MYCBP2 PAXIP1 ZFHX3 ZMIZ1	1.91e-04	113	51	4	int:TBR1
Cytoband	13q12-q14	USPL1 SMAD9	3.77e-06	3	52	2	13q12-q14
Cytoband	17p13.1	MYH1 MYH2 MYH4 MYH8	1.02e-05	118	52	4	17p13.1
Cytoband	Ensembl 112 genes in cytogenetic band chr17p13	MYH1 MYH2 MYH4 MYH8	6.45e-04	346	52	4	chr17p13
Cytoband	17q22	VEZF1 AKAP1	1.15e-03	44	52	2	17q22
Cytoband	15q14	BMF ZNF770	1.43e-03	49	52	2	15q14
Cytoband	19q13.12	ZNF790 ZNF829	3.06e-03	72	52	2	19q13.12
GeneFamily	Myosin heavy chains	MYH1 MYH2 MYH4 MYH8	2.48e-08	15	39	4	1098
GeneFamily	Non-canonical poly(A) polymerases	TENT4B TENT2	9.46e-05	7	39	2	1318
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF28 VEZF1 ZNF790 ZNF770 ZFHX3 ZNF227 ZNF829	7.67e-04	718	39	7	28
GeneFamily	WD repeat domain containing	PREB SEH1L CFAP251 SEC31A	2.38e-03	262	39	4	362
GeneFamily	PRD class homeoboxes and pseudogenes	ALX1 DMBX1	1.68e-02	92	39	2	521
Coexpression	HUMMERICH_BENIGN_SKIN_TUMOR_DN	MYH1 MYH2 MYH4 MYH8	6.52e-08	20	52	4	M1123
Coexpression	HUMMERICH_BENIGN_SKIN_TUMOR_DN	MYH1 MYH2 MYH4 MYH8	8.04e-08	21	52	4	MM1102
Coexpression	GSE7348_LPS_VS_TOLERIZED_AND_LPS_STIM_MACROPHAGE_DN	OGFRL1 MYCBP2 BICRAL ATM TENT2 PHF21A	1.24e-06	174	52	6	M6850
Coexpression	RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN	HIPK3 PROM1 GGNBP2 SPTBN1 ANKRD10 ZFHX3 BICRAL AKAP1 SMAD9 PROX1	3.55e-06	807	52	10	M16651
Coexpression	GSE411_WT_VS_SOCS3_KO_MACROPHAGE_DN	TENT4B VEZF1 MYCBP2 SPTBN1 ZMIZ1	4.78e-05	200	52	5	M5991
Coexpression	HUMMERICH_SKIN_CANCER_PROGRESSION_DN	MYH1 MYH4 MYH8 SPTBN1	5.27e-05	103	52	4	M1170
Coexpression	HUMMERICH_SKIN_CANCER_PROGRESSION_DN	MYH1 MYH4 MYH8 SPTBN1	7.05e-05	111	52	4	MM1111
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PROM1 MYH1 MYH2 MYH4 MYH8	1.37e-06	164	52	5	382e42701779d12a7948690b3be72d06dd75c8b4
Drug	2bq7	MYH1 MYH2 MYH4 MYH8 VEZF1 LRRC15	3.25e-07	123	51	6	CID006540267
Drug	fast white	MYH1 MYH2 MYH4 MYH8	2.35e-06	42	51	4	CID000024008
Drug	formycin triphosphate	MYH1 MYH2 MYH4 MYH8	5.16e-06	51	51	4	CID000122274
Drug	blebbistatin	RGMA MYH1 MYH2 MYH4 MYH8	6.13e-06	116	51	5	CID003476986
Drug	purealin	MYH1 MYH2 MYH4 MYH8	8.66e-06	58	51	4	CID006419303
Drug	clenbuterol	MYH1 MYH2 MYH4 MYH8 VEZF1	1.64e-05	142	51	5	CID000002783
Drug	SM-2	MYH1 MYH2 MYH4 MYH8	4.33e-05	87	51	4	CID000486033
Disease	dilated cardiomyopathy 1S (implicated_via_orthology)	MYH1 MYH2 MYH4 MYH8	1.52e-09	10	50	4	DOID:0110454 (implicated_via_orthology)
Disease	distal arthrogryposis type 2B3 (implicated_via_orthology)	MYH1 MYH2 MYH4 MYH8	1.52e-09	10	50	4	DOID:0111602 (implicated_via_orthology)
Disease	inclusion body myositis (implicated_via_orthology)	MYH1 MYH2 MYH4 MYH8	1.52e-09	10	50	4	DOID:3429 (implicated_via_orthology)
Disease	autosomal dominant hyaline body myopathy (implicated_via_orthology)	MYH1 MYH2 MYH4 MYH8	1.52e-09	10	50	4	DOID:0111269 (implicated_via_orthology)
Disease	congenital myopathy 6 (implicated_via_orthology)	MYH1 MYH2 MYH4 MYH8	1.52e-09	10	50	4	DOID:0080719 (implicated_via_orthology)
Disease	distal arthrogryposis type 2A (implicated_via_orthology)	MYH1 MYH2 MYH4 MYH8	1.52e-09	10	50	4	DOID:0111605 (implicated_via_orthology)
Disease	familial hypertrophic cardiomyopathy (implicated_via_orthology)	MYH1 MYH2 MYH4 MYH8	1.52e-09	10	50	4	DOID:0080326 (implicated_via_orthology)
Disease	distal arthrogryposis type 1 (implicated_via_orthology)	MYH1 MYH2 MYH4 MYH8	1.52e-09	10	50	4	DOID:0111596 (implicated_via_orthology)
Disease	distal myopathy (implicated_via_orthology)	MYH1 MYH2 MYH4 MYH8	3.57e-09	12	50	4	DOID:11720 (implicated_via_orthology)
Disease	myotonia congenita (implicated_via_orthology)	MYH1 MYH2 MYH4 MYH8	3.57e-09	12	50	4	DOID:2106 (implicated_via_orthology)
Disease	restrictive cardiomyopathy (implicated_via_orthology)	MYH1 MYH2 MYH4 MYH8	5.16e-09	13	50	4	DOID:397 (implicated_via_orthology)
Disease	distal arthrogryposis (implicated_via_orthology)	MYH1 MYH2 MYH4 MYH8	9.82e-09	15	50	4	DOID:0050646 (implicated_via_orthology)
Disease	dilated cardiomyopathy (implicated_via_orthology)	MYH1 MYH2 MYH4 MYH8 PROX1	2.48e-07	80	50	5	DOID:12930 (implicated_via_orthology)
Disease	myopathy (implicated_via_orthology)	MYH1 MYH2 MYH4 MYH8	1.34e-06	48	50	4	DOID:423 (implicated_via_orthology)
Disease	cardiomyopathy (implicated_via_orthology)	MYH1 MYH2 MYH4 MYH8	6.52e-06	71	50	4	DOID:0050700 (implicated_via_orthology)
Disease	Abnormality of the skeletal system	INTS1 ZMIZ1	7.83e-05	8	50	2	C4021790
Disease	anti-Mullerian hormone measurement	RGMA MYH4	5.24e-04	20	50	2	EFO_0004769
Disease	Drugs used in diabetes use measurement	MYCBP2 ZFHX3 ZMIZ1 PROX1	9.18e-04	255	50	4	EFO_0009924

Protein segments in the cluster

Peptide	Gene	Start	Entry
SNHQNQFSHVPLNNF	ALX1	266	Q15699
NQVNAGHLFVQQHTH	AKAP1	716	Q92667
QNCHLNHFYNNGILN	ANKRD10	181	Q9NXR5
QSVNLFARQLHIHNN	ADGRF4	216	Q8IZF3
SHQQLIDAQFNFQNA	TENT2	31	Q6PIY7
NVFRNNQYHLQGHAN	CFAP251	286	Q8TBY9
SLQGHAQQQAQHQAQ	NKX2-1	281	P43699
HLRSEHQAQQNQAEF	LILRA2	366	Q8N149
QQAHPHQFSQQQLQF	PAXIP1	456	Q6ZW49
FQQQHALQQQFHQLQ	PAXIP1	491	Q6ZW49
FLPLETTNNNNNHHQ	TENT4B	21	Q8NDF8
NWQERFQHLNESQHN	OGFRL1	221	Q5TC84
RTHLNFQEFRQQNHL	INTS1	1891	Q8N201
HQNNGAQLKQFIQRH	GGNBP2	46	Q9H3C7
NQNQHENDITHNLLS	CD1A	166	P06126
INFTNEKLQQFFNHH	MYH8	481	P13535
INFTNEKLQQFFNHH	MYH2	481	Q9UKX2
QQQQQYHHHHAQQSA	PHF21A	96	Q96BD5
INFTNEKLQQFFNHH	MYH1	481	P12882
QQKLTSAFQQQHLNF	HIPK3	1041	Q9H422
SAFQQQHLNFSQVQH	HIPK3	1046	Q9H422
NEVFTQFLADNHHQV	ATM	1071	Q13315
YNVNNLGIQQHHVQQ	BICRAL	326	Q6AI39
QACNHQNNGRFNFHR	DNAJB14	176	Q8TBM8
YNLHQQAAQQAQHAP	DMBX1	21	Q8NFW5
ADQFHRLHVQQHQQN	BMF	141	Q96LC9
VNNEVHFFENNNFNT	EIF2A	146	Q9BY44
FEIHIVAQFDNHNSQ	SEH1L	266	Q96EE3
HAILGNNHINQFQVQ	MEI4	246	A8MW99
NNHINQFQVQHYVSQ	MEI4	251	A8MW99
FHNNHNLQRLYLSNN	LRRC15	241	Q8TF66
QTVIAQSQHHQQFLD	RFX3	311	P48380
QNYHQGGQFEQHFQH	FAM98A	486	Q8NCA5
LNNHQFQFHMFNDED	NEXMIF	1131	Q5QGS0
NGENHNFHTANQRLQ	PROX1	396	Q92786
QNSFNISEHLNINEH	PROM1	576	O43490
INFTNEKLQQFFNHH	MYH4	481	Q9Y623
QFLHQSNVFHHINNI	MYCBP2	3691	O75592
LNQQIDFQAFHTNAE	RGMA	321	Q96B86
NNQLFAQLLAQSVHH	SMAD9	386	O15198
HYNLQNAFNLAEQHL	SPTBN1	231	Q01082
QDAHCQLLRFQAHQQ	PREB	86	Q9HCU5
FNDVSQNTHLRQDHN	USPL1	1011	Q5W0Q7
QAHEASHHQQQAAQN	VEZF1	11	Q14119
CQLFHQNHLNNVVVF	REXO5	86	Q96IC2
NQNSQFIQHQRIHFG	ZNF829	166	Q3KNS6
FVKHQQLHNETYQNN	ZNF770	96	Q6IQ21
FNQHTVFNLHQRLNT	ZNF790	151	Q6PG37
NTFSHESNFAQHQNI	ZNF790	596	Q6PG37
EQQQEQAAHNNFNFD	UCKL1	141	Q9NWZ5
VFNQQAHLAQHQRVH	ZNF28	671	P17035
FSQASNLQVHQNVHT	ZNF227	501	Q86WZ6
QGAEQQQQQHHVFIS	SEC31A	416	O94979
QCIKQHLQNPANFHN	ZMIZ1	16	Q9ULJ6
QEHQQLHFLSAQNQF	ZFHX3	2546	Q15911
QQHLSQAFINQHTVE	ZC3H8	176	Q8N5P1