Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionacetylcholine receptor regulator activity

SPDYE7P SPDYE2 SPDYE5 SPDYE2B SPDYE6 SPDYE16

1.17e-1027576GO:0030548
GeneOntologyMolecularFunctionneurotransmitter receptor regulator activity

SPDYE7P SPDYE2 SPDYE5 SPDYE2B SPDYE6 SPDYE16

1.48e-1028576GO:0099602
GeneOntologyMolecularFunctionpiRNA binding

PIWIL1 PIWIL3

1.19e-046572GO:0034584
GeneOntologyMolecularFunctionsignaling receptor regulator activity

IFNK IL32 SPDYE7P SPDYE2 SPDYE5 SPDYE2B SPDYE6 SPDYE16

3.42e-04616578GO:0030545
GeneOntologyMolecularFunctionprotein kinase binding

SPDYE7P PIWIL1 SPDYE2 SPDYE21 SPDYE5 SPDYE18 SPDYE2B SPDYE6 SPDYE16

7.63e-04873579GO:0019901
GeneOntologyMolecularFunctionRNA endonuclease activity

PIWIL1 INTS11 PIWIL3

1.50e-0379573GO:0004521
GeneOntologyMolecularFunctionkinase binding

SPDYE7P PIWIL1 SPDYE2 SPDYE21 SPDYE5 SPDYE18 SPDYE2B SPDYE6 SPDYE16

1.59e-03969579GO:0019900
GeneOntologyMolecularFunctiontau-protein kinase activity

MARK2 SIK3

1.78e-0322572GO:0050321
GeneOntologyBiologicalProcesspositive regulation of cyclin-dependent protein serine/threonine kinase activity

SPDYE7P SPDYE2 SPDYE5 SPDYE2B SPDYE6 SPDYE16

3.67e-1125536GO:0045737
GeneOntologyBiologicalProcesspositive regulation of cyclin-dependent protein kinase activity

SPDYE7P SPDYE2 SPDYE5 SPDYE2B SPDYE6 SPDYE16

7.75e-1128536GO:1904031
GeneOntologyBiologicalProcessregulation of cyclin-dependent protein serine/threonine kinase activity

SPDYE7P SPDYE2 SPDYE5 SPDYE2B SPDYE6 SPDYE16

1.67e-0796536GO:0000079
GeneOntologyBiologicalProcessregulation of cyclin-dependent protein kinase activity

SPDYE7P SPDYE2 SPDYE5 SPDYE2B SPDYE6 SPDYE16

2.13e-07100536GO:1904029
GeneOntologyBiologicalProcesspositive regulation of protein serine/threonine kinase activity

SPDYE7P SPDYE2 SPDYE5 SPDYE2B SPDYE6 SPDYE16

9.89e-06193536GO:0071902
GeneOntologyBiologicalProcesspositive regulation of protein phosphorylation

AKAP6 IFNK SPDYE7P SPDYE2 ATG14 SPDYE5 MARK2 SPDYE2B SPDYE6 SPDYE16

1.33e-057245310GO:0001934
GeneOntologyBiologicalProcesspositive regulation of phosphorylation

AKAP6 IFNK SPDYE7P SPDYE2 ATG14 SPDYE5 MARK2 SPDYE2B SPDYE6 SPDYE16

2.52e-057805310GO:0042327
GeneOntologyBiologicalProcesspositive regulation of protein kinase activity

SPDYE7P SPDYE2 SPDYE5 MARK2 SPDYE2B SPDYE6 SPDYE16

3.01e-05350537GO:0045860
GeneOntologyBiologicalProcesspositive regulation of phosphate metabolic process

AKAP6 IFNK SPDYE7P SPDYE2 ATG14 SPDYE5 MARK2 SPDYE2B SPDYE6 SPDYE16

6.91e-058795310GO:0045937
GeneOntologyBiologicalProcesspositive regulation of phosphorus metabolic process

AKAP6 IFNK SPDYE7P SPDYE2 ATG14 SPDYE5 MARK2 SPDYE2B SPDYE6 SPDYE16

6.91e-058795310GO:0010562
GeneOntologyBiologicalProcesspositive regulation of kinase activity

SPDYE7P SPDYE2 SPDYE5 MARK2 SPDYE2B SPDYE6 SPDYE16

7.56e-05405537GO:0033674
GeneOntologyBiologicalProcesspositive regulation of protein modification process

AKAP6 IFNK SPDYE7P SPDYE2 ATG14 SPDYE5 MARK2 SPDYE2B SPDYE6 SPDYE16

1.17e-049375310GO:0031401
GeneOntologyBiologicalProcessregulation of protein phosphorylation

AKAP6 IFNK SPDYE7P SPDYE2 ATG14 SPDYE5 MARK2 SPDYE2B EIF2AK3 SPDYE6 SPDYE16

1.18e-0411335311GO:0001932
GeneOntologyBiologicalProcessbiphenyl catabolic process

UGT2B28 UGT2B11

1.80e-048532GO:0070980
GeneOntologyBiologicalProcessregulation of phosphorylation

AKAP6 IFNK SPDYE7P SPDYE2 ATG14 SPDYE5 MARK2 SPDYE2B EIF2AK3 SPDYE6 SPDYE16

2.37e-0412265311GO:0042325
GeneOntologyBiologicalProcesspositive regulation of transferase activity

SPDYE7P SPDYE2 SPDYE5 MARK2 SPDYE2B SPDYE6 SPDYE16

2.45e-04490537GO:0051347
GeneOntologyBiologicalProcessbiphenyl metabolic process

UGT2B28 UGT2B11

2.88e-0410532GO:0018879
GeneOntologyBiologicalProcessregulation of protein serine/threonine kinase activity

SPDYE7P SPDYE2 SPDYE5 SPDYE2B SPDYE6 SPDYE16

3.03e-04358536GO:0071900
GeneOntologyBiologicalProcessregulation of protein modification process

AKAP6 IFNK PLAA SPDYE7P SPDYE2 ATG14 SPDYE5 MARK2 SPDYE2B EIF2AK3 SPDYE6 SPDYE16

3.16e-0414885312GO:0031399
GeneOntologyBiologicalProcessxenobiotic glucuronidation

UGT2B28 UGT2B11

4.21e-0412532GO:0052697
GeneOntologyBiologicalProcesspositive regulation of cell cycle

SPDYE7P SPDYE2 SPDYE5 SPDYE2B SPDYE6 SPDYE16

5.97e-04407536GO:0045787
GeneOntologyBiologicalProcessregulation of phosphate metabolic process

AKAP6 IFNK SPDYE7P SPDYE2 ATG14 SPDYE5 MARK2 SPDYE2B EIF2AK3 SPDYE6 SPDYE16

8.27e-0414215311GO:0019220
GeneOntologyBiologicalProcessregulation of phosphorus metabolic process

AKAP6 IFNK SPDYE7P SPDYE2 ATG14 SPDYE5 MARK2 SPDYE2B EIF2AK3 SPDYE6 SPDYE16

8.37e-0414235311GO:0051174
GeneOntologyBiologicalProcesspositive regulation of molecular function

AKAP6 PLAA SPDYE7P SPDYE2 SPDYE5 MARK2 SPDYE2B EIF2AK3 TRIM37 SPDYE6 SPDYE16

8.71e-0414305311GO:0044093
GeneOntologyBiologicalProcessregulation of protein kinase activity

SPDYE7P SPDYE2 SPDYE5 MARK2 SPDYE2B SPDYE6 SPDYE16

9.14e-04611537GO:0045859
GeneOntologyBiologicalProcesspositive regulation of protein metabolic process

AKAP6 IFNK SPDYE7P SPDYE2 ATG14 SPDYE5 MARK2 SPDYE2B EIF2AK3 SPDYE6 SPDYE16

1.02e-0314585311GO:0051247
GeneOntologyBiologicalProcesspositive regulation of catalytic activity

PLAA SPDYE7P SPDYE2 SPDYE5 MARK2 SPDYE2B EIF2AK3 SPDYE6 SPDYE16

1.12e-031028539GO:0043085
GeneOntologyCellularComponentnuclear outer membrane

UGT2B28 DMPK UGT2B11

1.59e-0440553GO:0005640
DomainSpeedy

SPDYE2 SPDYE21 SPDYE5 SPDYE2B SPDYE6 SPDYE16

2.00e-1311546IPR020984
DomainSpy1

SPDYE2 SPDYE21 SPDYE5 SPDYE2B SPDYE6 SPDYE16

2.00e-1311546PF11357
DomainPIWI

PIWIL1 PIWIL3

2.27e-048542PS50822
DomainPiwi

PIWIL1 PIWIL3

2.27e-048542IPR003165
DomainPiwi

PIWIL1 PIWIL3

2.27e-048542PF02171
DomainPiwi

PIWIL1 PIWIL3

2.27e-048542SM00950
DomainPAZ

PIWIL1 PIWIL3

2.92e-049542PS50821
DomainPAZ_dom

PIWIL1 PIWIL3

2.92e-049542IPR003100
DomainPAZ

PIWIL1 PIWIL3

2.92e-049542PF02170
DomainPAZ

PIWIL1 PIWIL3

2.92e-049542SM00949
DomainUDPGT

UGT2B28 UGT2B11

1.66e-0321542PS00375
DomainUDPGT

UGT2B28 UGT2B11

1.66e-0321542PF00201
DomainUDP_glucos_trans

UGT2B28 UGT2B11

1.66e-0321542IPR002213
DomainSpectrin/alpha-actinin

AKAP6 SPTAN1

3.85e-0332542IPR018159
DomainSPEC

AKAP6 SPTAN1

3.85e-0332542SM00150
DomainUBA

MARK2 SIK3

7.18e-0344542IPR015940
DomainUBA

MARK2 SIK3

8.16e-0347542PS50030
Domain-

PIWIL1 PIWIL3

8.16e-03475423.30.420.10
Pubmed

Murine fertility and spermatogenesis are independent of the testis-specific Spdye4a gene.

SPDYE7P SPDYE2 SPDYE5 SPDYE2B SPDYE6 SPDYE16

1.38e-15958636272447
Pubmed

Identification and comparative analysis of multiple mammalian Speedy/Ringo proteins.

SPDYE7P SPDYE2 SPDYE5 SPDYE2B SPDYE6 SPDYE16

2.80e-141358615611625
Pubmed

Characterization of a new family of cyclin-dependent kinase activators.

SPDYE7P SPDYE2 SPDYE5 SPDYE2B SPDYE6 SPDYE16

2.01e-131758615574121
Pubmed

Active conformation of the p97-p47 unfoldase complex.

PLAA SPTAN1 UBXN7

1.97e-061558335552390
Pubmed

Quantitative analysis of UGT2B28 mRNA expression by real-time RT-PCR and application to human tissue distribution study.

UGT2B28 UGT2B11

2.73e-06258221679149
Pubmed

RNF17 blocks promiscuous activity of PIWI proteins in mouse testes.

PIWIL1 RNF17

2.73e-06258226115953
Pubmed

Evolution of the Cdk-activator Speedy/RINGO in vertebrates.

SPDYE2 SPDYE6

8.19e-06358222763696
Pubmed

TLR-mediated induction of proinflammatory cytokine IL-32 in corneal epithelium.

IL32 TLR5

8.19e-06358223534905
Pubmed

The ataxia (axJ) mutation causes abnormal GABAA receptor turnover in mice.

GABRG1 USP14

8.19e-06358219759851
Pubmed

Genetic variants in Piwi-interacting RNA pathway genes confer susceptibility to spermatogenic failure in a Chinese population.

PIWIL1 PIWIL3

1.64e-05458220940137
Pubmed

Proteome-wide analysis of USP14 substrates revealed its role in hepatosteatosis via stabilization of FASN.

USP14 RARS1 MYO6 SMCHD1 SPTAN1 SNRNP200

1.99e-0533458630425250
Pubmed

Cdx2 regulates endo-lysosomal function and epithelial cell polarity.

MYO6 SPTAN1 MARK2

2.32e-053358320551175
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

AKAP6 TUBGCP6 SMCHD1 UBXN7 SIK3 MYEF2 PHF21A

2.78e-0552958714621295
Pubmed

Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides.

INTS10 SIK3

5.71e-05758218193046
Pubmed

Regulation of the polarity kinases PAR-1/MARK by 14-3-3 interaction and phosphorylation.

MARK2 SIK3

5.71e-05758216968750
Pubmed

Weak activity of UDP-glucuronosyltransferase toward Bisphenol analogs in mouse perinatal development.

UGT2B28 UGT2B11

5.71e-05758226074487
Pubmed

Hetero-oligomer formation of mouse UDP-glucuronosyltransferase (UGT) 2b1 and 1a1 results in the gain of glucuronidation activity towards morphine, an activity which is absent in homo-oligomers of either UGT.

UGT2B28 UGT2B11

7.60e-05858232093886
Pubmed

Ubiquitin-dependent intramembrane rhomboid protease promotes ERAD of membrane proteins.

RHBDL3 EIF2AK3

7.60e-05858222795130
Pubmed

Identification of eight members of the Argonaute family in the human genome.

PIWIL1 PIWIL3

9.77e-05958212906857
Pubmed

Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci.

INTS10 TRPM1 SIK3

1.03e-045458323505323
Pubmed

The USP10-HDAC6 axis confers cisplatin resistance in non-small cell lung cancer lacking wild-type p53.

RARS1 SPTAN1 SNRNP200

1.34e-045958332382008
Pubmed

Nuclear-localized Asunder regulates cytoplasmic dynein localization via its role in the integrator complex.

INTS10 INTS11

1.49e-041158223904267
Pubmed

New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.

MYO6 SMCHD1 SPTAN1 INTS11 EIF2AK3 SNRNP200

2.11e-0451358625798074
Pubmed

Structure of the catalytic core of the Integrator complex.

INTS10 INTS11

2.46e-041458233548203
Pubmed

The Human Integrator Complex Facilitates Transcriptional Elongation by Endonucleolytic Cleavage of Nascent Transcripts.

INTS10 INTS11

2.46e-041458232697989
Pubmed

INTS10-INTS13-INTS14 form a functional module of Integrator that binds nucleic acids and the cleavage module.

INTS10 INTS11

2.46e-041458232647223
Pubmed

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1.

MARK2 SIK3

2.83e-041558214976552
Pubmed

STING Senses Microbial Viability to Orchestrate Stress-Mediated Autophagy of the Endoplasmic Reticulum.

ATG14 EIF2AK3

2.83e-041558229056340
Pubmed

Genome-wide CRISPR screens using isogenic cells reveal vulnerabilities conferred by loss of tumor suppressors.

USP14 SMCHD1 MARK2 DMPK EIF2AK3

3.33e-0435958535559673
Pubmed

Tdrd6 is required for spermiogenesis, chromatoid body architecture, and regulation of miRNA expression.

PIWIL1 RNF17

3.66e-041758219345099
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

USP14 RARS1 PLAA MYO6 SMCHD1 SPTAN1 INTS11 SNRNP200 MYEF2

3.80e-04135358929467282
Pubmed

TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.

PLAA SMCHD1 SNRNP200 MYEF2

5.06e-0422058435785414
Pubmed

Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations.

IFNK PLAA

6.18e-042258220574843
Pubmed

The small GTPase Rac1 regulates auditory hair cell morphogenesis.

MYO6 SPTAN1

6.76e-042358220016102
Pubmed

LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells.

TUBGCP6 RARS1 SPTAN1 MARK2 SNRNP200 TRIM37

6.76e-0463958623443559
Pubmed

Nuclear lamina genetic variants, including a truncated LAP2, in twins and siblings with nonalcoholic fatty liver disease.

RARS1 MYO6 SPTAN1 SNRNP200

7.45e-0424458428902428
Pubmed

The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer.

INTS10 INTS11

8.00e-042558234004147
Pubmed

Characterization of gene regulation and protein interaction networks for Matrin 3 encoding mutations linked to amyotrophic lateral sclerosis and myopathy.

SMCHD1 SNRNP200 MYEF2

8.15e-0410958329511296
Pubmed

The DNA sequence of human chromosome 7.

SPDYE21 SPDYE5 SPDYE2B SPDYE6 SPDYE16

8.45e-0444158512853948
Pubmed

A germline-specific class of small RNAs binds mammalian Piwi proteins.

LYPD4 PIWIL1 ATG14 MARK2 CATSPERG

9.25e-0445058516751776
Pubmed

ISG15 Connects Autophagy and IFN-γ-Dependent Control of Toxoplasma gondii Infection in Human Cells.

RARS1 MYO6 SPTAN1 SNRNP200

1.06e-0326858433024031
Pubmed

14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK.

MARK2 SIK3

1.15e-033058216306228
Pubmed

PINK1 Content in Mitochondria is Regulated by ER-Associated Degradation.

RARS1 MYO6 SPTAN1 SNRNP200 PIWIL3

1.20e-0347758531300519
Pubmed

STK11 is required for the normal program of ciliated cell differentiation in airways.

MARK2 SIK3

1.23e-033158231636950
Pubmed

An Interaction Landscape of Ubiquitin Signaling.

USP14 PLAA MYO6 SPTAN1 UBXN7

1.24e-0348158528190767
Pubmed

The AAA-ATPase ATAD1 and its partners promote degradation of desmin intermediate filaments in muscle.

USP14 PLAA

1.31e-033258236278411
CytobandEnsembl 112 genes in cytogenetic band chr7q11

SPDYE7P SPDYE21 SPDYE5 SPDYE18 SPDYE16

2.45e-05271585chr7q11
Cytoband7q11.23

SPDYE7P SPDYE5 SPDYE18

2.59e-04975837q11.23
Cytoband18p11.32

USP14 SMCHD1

2.94e-042058218p11.32
Cytoband7q22.1

SPDYE2 SPDYE2B SPDYE6

4.06e-041135837q22.1
Cytoband4q13.2

UGT2B28 UGT2B11

7.12e-04315824q13.2
Cytoband15q21.1

GATM MYEF2

1.02e-033758215q21.1
CytobandEnsembl 112 genes in cytogenetic band chr7q22

SPDYE2 SPDYE2B SPDYE6

2.72e-03219583chr7q22
GeneFamilySpeedy/RINGO cell cycle regulator family

SPDYE7P SPDYE2 SPDYE5 SPDYE2B SPDYE6

4.68e-1112435756
GeneFamilyArgonaute/PIWI family

PIWIL1 PIWIL3

1.53e-048432408
GeneFamilyIntegrator complex

INTS10 INTS11

5.69e-04154321366
GeneFamilyUDP glucuronosyltransferases

UGT2B28 UGT2B11

2.62e-0332432363
ComputationalNeighborhood of RFC1

INTS10 USP14 UBXN7 SIK3

1.47e-04109274MORF_RFC1
Diseasefish oil supplement exposure measurement, high density lipoprotein cholesterol measurement

INTS10 SIK3

6.36e-057522EFO_0004612, EFO_0600007
Diseasephosphatidylcholine 36:4 measurement

UGT2B28 UGT2B11

4.58e-0418522EFO_0010382
Diseasetriacylglycerol 56:4 measurement

SYT16 SIK3

8.20e-0424522EFO_0010431

Protein segments in the cluster

PeptideGeneStartEntry
KGCTMIRWKINNLIA

CATSPERG

1096

Q6ZRH7
IQMQLCRKENLKDWM

EIF2AK3

886

Q9NZJ5
WKIMSCKMRIEQLKQ

ATG14

111

Q6ZNE5
LCLQMGVIMFLKQIW

ANO3

691

Q9BYT9
KILNVVGMRCEWQMD

INTS10

261

Q9NVR2
KWLSMNVLMLDEKRV

GATM

356

P50440
IFRKWAGNEKNMVIM

INTS11

336

Q5TA45
EMKNAMRKVWCCQIL

OR4P4

291

Q8NGL7
KMQQLRERCMKAWLL

PDZD4

421

Q76G19
MWICPRCQDQMLKKE

PHF21A

526

Q96BD5
KMEMILQQSGKWRRA

POU5F2

201

Q8N7G0
KWLLMRNMVCKLQEG

LYPD4

46

Q6UWN0
LLQLKLMMWALKDVC

TUBGCP6

1631

Q96RT7
IMNKWDMLKRGEVSC

DMPK

101

Q09013
CDKVMRWFQAMLQRL

IL32

151

P24001
PNMKQAKMWRDLEQL

IFT81

631

Q8WYA0
AKMWRDLEQLMECKK

IFT81

636

Q8WYA0
NKKIWWIIRGPMMLC

GLP2R

336

O95838
KVLMLNSNMVGKIWI

GABRG1

131

Q8N1C3
MWKDMEECQNKLSLI

CENPK

31

Q9BS16
CLDMKHKLIQLMWND

HEATR4

661

Q86WZ0
DMIQKCLWLEILMGI

IFNK

6

Q9P0W0
KRGTLEQIMKDRWMN

MARK2

291

Q7KZI7
MWMGLIQLVEGVKRK

CSAG2

1

Q9Y5P2
WQQKIAMKMELLGCQ

DCBLD2

436

Q96PD2
IAQQMNCKMGGALWK

PIWIL3

626

Q7Z3Z3
LQMNCKMGGELWRVD

PIWIL1

606

Q96J94
DRQTGKILKVNMWRM

RARS1

621

P54136
KILKVNMWRMLLCEA

RARS1

626

P54136
IIAKMRMVALKAGWQ

SSTR1

246

P30872
KQQAMWRVPSDLKML

TRIM37

661

O94972
IIKNINPARISMKMW

SMCHD1

1401

A6NHR9
MKRKEMIGWIALGQN

SYT16

601

Q17RD7
MKWQAIKDLMREKVG

MYEF2

111

Q9P2K5
WSGMKCQFKLLRMAV

RHBDL3

296

P58872
LSMEQICKHKWMKLG

SIK3

306

Q9Y2K2
MKRIHGEIIMQNNWC

SERTAD4

136

Q9NUC0
WVAEMLCGLKMKLKR

SPDYE2B

171

A6NHP3
GLKDMLRMIASQWKE

AKAP6

856

Q13023
MEALWAMIDCLQGKQ

RNF17

1571

Q9BXT8
WVVEMLCGLKMKLKR

SPDYE16

131

A6NNV3
WVAEMLCGLKMKLKR

SPDYE18

171

P0DV79
WVAEMLCGLKMKLKR

SPDYE21

171

A0A494C086
WVAEMLCGLKMKLKR

SPDYE2

171

Q495Y8
WVAEMLCGLKMKLKR

SPDYE5

171

A6NIY4
WVAEMLCGLKMKLKR

SPDYE6

171

P0CI01
IWVAEMLCGLKMKLK

SPDYE7P

26

Q495Y7
EKAWVQRRMMLDQCL

SPTAN1

1431

Q13813
KVWLNDKCMMTLQGH

PLAA

136

Q9Y263
LLHVWMCLVRMKQEG

UQCC1

151

Q9NVA1
WMNMKTILKELVQRG

UGT2B11

36

O75310
KNGMGLCRLSMKVWE

TFDP3

106

Q5H9I0
LMKRQKMAVFLWQRG

TRPM1

621

Q7Z4N2
TLNLCKMIDKRMWQS

SNRNP200

1111

O75643
LRKMQSLWRKMCENH

TRIM51G

141

A0A3B3IT33
TAKECGQMQNKWLMI

UBXN7

156

O94888
WVAEMLCGLKMKLKR

nan

131

A6NJR5
WMNMKTILKELVQRG

UGT2B28

36

Q9BY64
WGKCMNPFRNMVLEI

TLR5

216

O60602
NECWIQMMRVLQQKL

USP14

201

P54578
ACIKMQKTIRMWLCK

MYO6

816

Q9UM54