Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionsteroid 11-beta-monooxygenase activity

CYP11B1 CYP11B2

1.51e-052782GO:0004507
GeneOntologyMolecularFunctioncorticosterone 18-monooxygenase activity

CYP11B1 CYP11B2

1.51e-052782GO:0047783
GeneOntologyMolecularFunctionATP hydrolysis activity

KIF2B ABCA12 SMCHD1 DHX32 CHD8 ATP11A UPF1 ATP13A2 DDX1

5.46e-05441789GO:0016887
GeneOntologyBiologicalProcesscell-cell adhesion

EPHB6 CELSR1 ABCA12 CADM4 ARID2 FAT3 ITGA10 SLITRK3 NCK1 ACTL6B CTNNB1 IHH ITGAD ITGAM PCDH17 NCK2

2.20e-0610777816GO:0098609
GeneOntologyBiologicalProcessbone remodeling

NF1 CTNNB1 IHH IDUA LEPR INPP4B

8.65e-06127786GO:0046849
GeneOntologyBiologicalProcessneuron projection development

EPHB6 NF1 LINGO1 PLEKHG4 FAT3 ZNF335 TET1 KDR SLITRK3 NCK1 ACTL6B SRGAP2 GRIN1 FLRT2 CTNNB1 NCK2

2.05e-0512857816GO:0031175
GeneOntologyBiologicalProcessneuron development

EPHB6 NF1 LINGO1 PLEKHG4 FAT3 ZNF335 TET1 KDR SLITRK3 NCK1 ACTL6B SRGAP2 GRIN1 FLRT2 CTNNB1 IHH NCK2

2.63e-0514637817GO:0048666
GeneOntologyBiologicalProcessnegative regulation of oligodendrocyte differentiation

NF1 LINGO1 CTNNB1

4.08e-0518783GO:0048715
GeneOntologyBiologicalProcessleukocyte proliferation

EPHB6 NF1 ZNF335 NCK1 CTNNB1 IHH ITGAD ITGAM NCK2

4.56e-05445789GO:0070661
GeneOntologyBiologicalProcessregulation of blood volume by renal aldosterone

CYP11B1 CYP11B2

8.43e-054782GO:0002017
GeneOntologyBiologicalProcessnegative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation

NCK1 NCK2

8.43e-054782GO:1903912
GeneOntologyBiologicalProcessT cell proliferation

EPHB6 NCK1 CTNNB1 IHH ITGAD ITGAM NCK2

1.09e-04288787GO:0042098
GeneOntologyBiologicalProcessregulation of synapse assembly

SRGAP3 SLITRK3 SRGAP2 GRIN1 FLRT2 CTNNB1

1.17e-04202786GO:0051963
GeneOntologyBiologicalProcesslymphocyte proliferation

EPHB6 ZNF335 NCK1 CTNNB1 IHH ITGAD ITGAM NCK2

1.29e-04398788GO:0046651
GeneOntologyBiologicalProcesscell morphogenesis

EPHB6 PLEKHG4 HPN FAT3 ZNF335 TET1 KDR SLITRK3 SRGAP2 GRIN1 FLRT2 CTNNB1 IHH IDUA

1.38e-0411947814GO:0000902
GeneOntologyBiologicalProcesspositive regulation of translation in response to endoplasmic reticulum stress

NCK1 NCK2

1.40e-045782GO:0036493
GeneOntologyBiologicalProcessmononuclear cell proliferation

EPHB6 ZNF335 NCK1 CTNNB1 IHH ITGAD ITGAM NCK2

1.48e-04406788GO:0032943
GeneOntologyBiologicalProcesssynapse assembly

SRGAP3 SLITRK3 SRGAP2 GRIN1 FLRT2 CTNNB1 PCDH17

1.65e-04308787GO:0007416
GeneOntologyBiologicalProcessregulation of cell junction assembly

SRGAP3 KDR SLITRK3 SRGAP2 GRIN1 FLRT2 CTNNB1

1.68e-04309787GO:1901888
GeneOntologyBiologicalProcesssmall GTPase-mediated signal transduction

CELSR1 NF1 PLEKHG4 SRGAP3 CADM4 SRGAP1 RALGPS2 SRGAP2 CGNL1

1.93e-04538789GO:0007264
GeneOntologyBiologicalProcessglial cell migration

NF1 SRGAP2 GRIN1 CTNNB1

2.41e-0480784GO:0008347
GeneOntologyBiologicalProcessregulation of bone remodeling

NF1 IDUA LEPR INPP4B

2.41e-0480784GO:0046850
GeneOntologyBiologicalProcesssynapse organization

NF1 SRGAP3 SLITRK3 SRGAP2 GRIN1 FLRT2 CTNNB1 ITGAM SEZ6L2 PCDH17

2.51e-046857810GO:0050808
GeneOntologyBiologicalProcesscell junction organization

NF1 SLC39A9 SRGAP3 KDR SLITRK3 SRGAP2 GRIN1 FLRT2 CTNNB1 ITGAM SEZ6L2 PCDH17

2.81e-049747812GO:0034330
GeneOntologyBiologicalProcesscell junction assembly

SLC39A9 SRGAP3 KDR SLITRK3 SRGAP2 GRIN1 FLRT2 CTNNB1 PCDH17

2.92e-04569789GO:0034329
GeneOntologyBiologicalProcessT cell activation

EPHB6 ARID2 NCK1 ACTL6B CTNNB1 IHH ITGAD ITGAM LEPR NCK2

3.02e-047017810GO:0042110
GeneOntologyBiologicalProcesssensory organ morphogenesis

CELSR1 NF1 HPN FAT3 KDR CTNNB1 IHH

3.18e-04343787GO:0090596
GeneOntologyBiologicalProcessnegative regulation of cartilage development

CTNNB1 IHH IDUA

3.40e-0436783GO:0061037
GeneOntologyBiologicalProcesspositive regulation of mesenchymal cell proliferation

KDR CTNNB1 IHH

3.40e-0436783GO:0002053
GeneOntologyBiologicalProcessnegative regulation of PERK-mediated unfolded protein response

NCK1 NCK2

3.90e-048782GO:1903898
GeneOntologyBiologicalProcesseiF2alpha phosphorylation in response to endoplasmic reticulum stress

NCK1 NCK2

3.90e-048782GO:0036492
GeneOntologyBiologicalProcessregulation of translation initiation in response to endoplasmic reticulum stress

NCK1 NCK2

3.90e-048782GO:0036491
GeneOntologyBiologicalProcesspositive regulation of translation in response to stress

NCK1 NCK2

3.90e-048782GO:0032056
GeneOntologyBiologicalProcesssignal complex assembly

NCK1 NCK2

3.90e-048782GO:0007172
GeneOntologyBiologicalProcessnegative regulation of glial cell differentiation

NF1 LINGO1 CTNNB1

4.31e-0439783GO:0045686
GeneOntologyBiologicalProcessregulation of long-term neuronal synaptic plasticity

NF1 KDR GRIN1

4.65e-0440783GO:0048169
GeneOntologyBiologicalProcesstissue remodeling

NF1 CTNNB1 IHH IDUA LEPR INPP4B

4.74e-04262786GO:0048771
GeneOntologyBiologicalProcesscamera-type eye morphogenesis

NF1 FAT3 KDR CTNNB1 IHH

4.78e-04171785GO:0048593
GeneOntologyBiologicalProcessbone resorption

NF1 CTNNB1 IHH IDUA

5.43e-0499784GO:0045453
GeneOntologyBiologicalProcesscell-matrix adhesion

NF1 ITGA10 KDR CTNNB1 ITGAD ITGAM

5.56e-04270786GO:0007160
GeneOntologyBiologicalProcesscortisol biosynthetic process

CYP11B1 CYP11B2

6.23e-0410782GO:0034651
GeneOntologyBiologicalProcesscoronary artery morphogenesis

ARID2 CTNNB1

6.23e-0410782GO:0060982
GeneOntologyBiologicalProcesstertiary alcohol biosynthetic process

CYP11B1 CYP11B2

6.23e-0410782GO:1902645
GeneOntologyBiologicalProcesspositive regulation of lymphocyte activation

EPHB6 ARID2 ZNF335 NCK1 ACTL6B IHH NCK2

6.33e-04385787GO:0051251
GeneOntologyBiologicalProcessregulation of synapse organization

NF1 SRGAP3 SLITRK3 SRGAP2 GRIN1 FLRT2 CTNNB1

6.53e-04387787GO:0050807
GeneOntologyBiologicalProcessregulation of mesenchymal cell proliferation

KDR CTNNB1 IHH

6.58e-0445783GO:0010464
GeneOntologyBiologicalProcessregulation of synapse structure or activity

NF1 SRGAP3 SLITRK3 SRGAP2 GRIN1 FLRT2 CTNNB1

7.36e-04395787GO:0050803
GeneOntologyBiologicalProcessbranching involved in blood vessel morphogenesis

KDR CTNNB1 IHH

7.48e-0447783GO:0001569
GeneOntologyBiologicalProcessaldosterone biosynthetic process

CYP11B1 CYP11B2

7.60e-0411782GO:0032342
GeneOntologyBiologicalProcesspositive regulation of T cell activation

EPHB6 ARID2 NCK1 ACTL6B IHH NCK2

8.07e-04290786GO:0050870
GeneOntologyBiologicalProcessneuron projection morphogenesis

EPHB6 PLEKHG4 ZNF335 TET1 KDR SLITRK3 SRGAP2 GRIN1 FLRT2 CTNNB1

8.60e-048027810GO:0048812
GeneOntologyBiologicalProcesscortisol metabolic process

CYP11B1 CYP11B2

9.09e-0412782GO:0034650
GeneOntologyBiologicalProcesspositive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

NCK1 NCK2

9.09e-0412782GO:1902237
GeneOntologyBiologicalProcesscell-substrate adhesion

NF1 ITGA10 KDR SRGAP2 CTNNB1 ITGAD ITGAM

9.15e-04410787GO:0031589
GeneOntologyBiologicalProcesssteroid hormone biosynthetic process

CYP11B1 CYP11B2 DHRS11

9.51e-0451783GO:0120178
GeneOntologyBiologicalProcessplasma membrane bounded cell projection morphogenesis

EPHB6 PLEKHG4 ZNF335 TET1 KDR SLITRK3 SRGAP2 GRIN1 FLRT2 CTNNB1

1.01e-038197810GO:0120039
GeneOntologyBiologicalProcesseye morphogenesis

NF1 FAT3 KDR CTNNB1 IHH

1.06e-03204785GO:0048592
GeneOntologyBiologicalProcessregulation of PERK-mediated unfolded protein response

NCK1 NCK2

1.07e-0313782GO:1903897
GeneOntologyBiologicalProcessregulation of translation in response to endoplasmic reticulum stress

NCK1 NCK2

1.07e-0313782GO:0036490
GeneOntologyBiologicalProcessmineralocorticoid biosynthetic process

CYP11B1 CYP11B2

1.07e-0313782GO:0006705
GeneOntologyBiologicalProcessregulation of Schwann cell migration

NF1 GRIN1

1.07e-0313782GO:1900147
GeneOntologyBiologicalProcesslymphocyte activation

EPHB6 ARID2 ZNF335 NCK1 ACTL6B CTNNB1 IHH ITGAD ITGAM LEPR NCK2

1.07e-039767811GO:0046649
GeneOntologyBiologicalProcesscell projection morphogenesis

EPHB6 PLEKHG4 ZNF335 TET1 KDR SLITRK3 SRGAP2 GRIN1 FLRT2 CTNNB1

1.08e-038267810GO:0048858
GeneOntologyBiologicalProcesspositive regulation of leukocyte activation

EPHB6 ARID2 ZNF335 NCK1 ACTL6B IHH NCK2

1.10e-03423787GO:0002696
GeneOntologyBiologicalProcessephrin receptor signaling pathway

EPHB6 NCK1 NCK2

1.12e-0354783GO:0048013
GeneOntologyBiologicalProcessregulation of leukocyte differentiation

NF1 ARID2 ACTL6B CTNNB1 IHH ITGAM INPP4B

1.19e-03429787GO:1902105
GeneOntologyBiologicalProcesscell-cell adhesion via plasma-membrane adhesion molecules

CELSR1 CADM4 FAT3 SLITRK3 ITGAM PCDH17

1.20e-03313786GO:0098742
GeneOntologyBiologicalProcessSchwann cell migration

NF1 GRIN1

1.25e-0314782GO:0036135
GeneOntologyBiologicalProcessprimary alcohol biosynthetic process

CYP11B1 CYP11B2

1.25e-0314782GO:0034309
GeneOntologyBiologicalProcessaldosterone metabolic process

CYP11B1 CYP11B2

1.25e-0314782GO:0032341
GeneOntologyBiologicalProcesspositive regulation of leukocyte cell-cell adhesion

EPHB6 ARID2 NCK1 ACTL6B IHH NCK2

1.28e-03317786GO:1903039
GeneOntologyBiologicalProcessgliogenesis

NF1 LINGO1 SRGAP2 GRIN1 CTNNB1 ITGAM LEPR

1.29e-03435787GO:0042063
GeneOntologyBiologicalProcessdevelopmental maturation

NF1 KDR ACTL6B GRIN1 CTNNB1 IHH SEZ6L2

1.36e-03439787GO:0021700
GeneOntologyBiologicalProcessregulation of oligodendrocyte differentiation

NF1 LINGO1 CTNNB1

1.38e-0358783GO:0048713
GeneOntologyBiologicalProcessregulation of tissue remodeling

NF1 IDUA LEPR INPP4B

1.42e-03128784GO:0034103
GeneOntologyBiologicalProcessneuron migration

CELSR1 FAT3 SRGAP2 FLRT2 CTNNB1

1.42e-03218785GO:0001764
GeneOntologyBiologicalProcessSchwann cell proliferation

NF1 CTNNB1

1.44e-0315782GO:0014010
GeneOntologyBiologicalProcesspeptidyl-serine dephosphorylation

NCK1 NCK2

1.44e-0315782GO:0070262
GeneOntologyBiologicalProcessregulation of translational initiation by eIF2 alpha phosphorylation

NCK1 NCK2

1.44e-0315782GO:0010998
GeneOntologyBiologicalProcessmesenchymal cell proliferation

KDR CTNNB1 IHH

1.45e-0359783GO:0010463
GeneOntologyBiologicalProcessnegative regulation of osteoclast differentiation

NF1 CTNNB1 INPP4B

1.45e-0359783GO:0045671
GeneOntologyBiologicalProcesspositive regulation of cell activation

EPHB6 ARID2 ZNF335 NCK1 ACTL6B IHH NCK2

1.54e-03449787GO:0050867
HumanPhenoElevated serum 11-deoxycortisol

CYP11B1 CYP11B2 CTNNB1

1.36e-059293HP:0025436
HumanPhenoNeoplasm of the endocrine system

NF1 CYP11B1 CYP11B2 ARID2 SRGAP1 CTNNB1 PDE11A

1.87e-05155297HP:0100568
HumanPhenoIncreased circulating cortisol level

CYP11B1 CYP11B2 CTNNB1 PDE11A

2.73e-0532294HP:0003118
MousePhenoabnormal myocardium layer morphology

TNNI3K NF1 SYNM CYP11B1 CYP11B2 ARID2 ATP11A FLRT2 IDUA LEPR

1.94e-054146510MP:0005329
MousePhenoabnormal urine progesterone level

CYP11B1 CYP11B2

2.13e-052652MP:0011545
MousePhenoabnormal urine deoxycorticosterone level

CYP11B1 CYP11B2

2.13e-052652MP:0011552
MousePhenodecreased urine corticosterone level

CYP11B1 CYP11B2

2.13e-052652MP:0011550
MousePhenoincreased urine deoxycorticosterone level

CYP11B1 CYP11B2

2.13e-052652MP:0011553
MousePhenoincreased urine progesterone level

CYP11B1 CYP11B2

2.13e-052652MP:0011546
MousePhenoabnormal heart layer morphology

TNNI3K NF1 SYNM CYP11B1 CYP11B2 ARID2 ATP11A FLRT2 IDUA LEPR

2.29e-054226510MP:0010545
MousePhenoincreased brain size

CELSR1 CYP11B1 CYP11B2 CHD8 CTNNB1

4.58e-0585655MP:0005238
MousePhenoabnormal cardiac muscle tissue morphology

TNNI3K NF1 SYNM CYP11B1 CYP11B2 ARID2 ATP11A FLRT2 IDUA LEPR

7.96e-054896510MP:0010630
MousePhenoabnormal adrenal gland zona glomerulosa morphology

CYP11B1 CYP11B2

1.27e-044652MP:0008293
MousePhenodecreased urine aldosterone level

CYP11B1 CYP11B2

1.27e-044652MP:0011541
MousePhenoabnormal urine aldosterone level

CYP11B1 CYP11B2

1.27e-044652MP:0011539
MousePhenoabnormal urine corticosterone level

CYP11B1 CYP11B2

1.27e-044652MP:0011548
MousePhenodecreased urine hormone level

CYP11B1 CYP11B2

1.27e-044652MP:0014459
MousePhenoabnormal myocardial fiber morphology

TNNI3K SYNM CYP11B1 CYP11B2 IDUA LEPR

2.02e-04183656MP:0000278
MousePhenoincreased adrenal gland zona fasciculata size

CYP11B1 CYP11B2

2.11e-045652MP:0014286
MousePhenoabnormal metabolism

NF1 HP SYNM ABCA12 CYP11B1 CYP11B2 TET1 IHH IDUA SLC25A19 ATP13A2 LEPR PPOX

3.15e-049366513MP:0005266
MousePhenouterus adenomyosis

CYP11B1 CYP11B2

3.16e-046652MP:0009221
MousePhenoincreased urine hormone level

CYP11B1 CYP11B2

3.16e-046652MP:0014458
MousePhenoadrenal gland hyperplasia

CYP11B1 CYP11B2

3.16e-046652MP:0009078
MousePhenoocular hypertelorism

TET1 CTNNB1 IDUA

3.22e-0429653MP:0001300
MousePhenoabnormal enzyme/coenzyme activity

NF1 CYP11B1 CYP11B2 IHH SLC25A19 LEPR PPOX

3.59e-04287657MP:0005584
MousePhenoincreased susceptibility to otitis media

CELSR1 CTNNB1 IDUA

3.93e-0431653MP:0001850
MousePhenoabnormal fluid intake

SYNM CYP11B1 CYP11B2 GRIN1 LEPR

4.19e-04136655MP:0011947
MousePhenoabnormal urine hormone level

CYP11B1 CYP11B2

4.40e-047652MP:0011538
MousePhenopituitary gland hyperplasia

CYP11B1 CYP11B2

4.40e-047652MP:0000635
MousePhenoenlarged adrenal glands

CYP11B1 CYP11B2 LEPR

5.18e-0434653MP:0000642
MousePhenoincreased circulating angiotensin II level

CYP11B1 CYP11B2

5.85e-048652MP:0031232
MousePhenoincreased angiotensin II level

CYP11B1 CYP11B2

5.85e-048652MP:0031229
MousePhenodecreased cardiac output

SYNM IDUA LEPR

6.66e-0437653MP:0003393
DomainNCK

NCK1 NCK2

1.72e-052782IPR017304
DomainCyt_P450_mitochondrial

CYP11B1 CYP11B2

1.72e-052782IPR002399
DomainIntegrin_alpha-2

ITGA10 ITGAD ITGAM

5.47e-0518783IPR013649
DomainIntegrin_alpha2

ITGA10 ITGAD ITGAM

5.47e-0518783PF08441
DomainIntegrin_alpha

ITGA10 ITGAD ITGAM

5.47e-0518783IPR000413
DomainINTEGRIN_ALPHA

ITGA10 ITGAD ITGAM

5.47e-0518783PS00242
DomainInt_alpha_beta-p

ITGA10 ITGAD ITGAM

6.47e-0519783IPR013519
DomainInt_alpha

ITGA10 ITGAD ITGAM

6.47e-0519783SM00191
DomainFCH

SRGAP3 SRGAP1 SRGAP2

1.02e-0422783PF00611
DomainFG_GAP

ITGA10 ITGAD ITGAM

1.02e-0422783PS51470
DomainFCH

SRGAP3 SRGAP1 SRGAP2

1.02e-0422783SM00055
DomainFCH_dom

SRGAP3 SRGAP1 SRGAP2

1.17e-0423783IPR001060
DomainFG-GAP

ITGA10 ITGAD ITGAM

1.33e-0424783PF01839
DomainFG-GAP

ITGA10 ITGAD ITGAM

1.33e-0424783IPR013517
DomainF_BAR

SRGAP3 SRGAP1 SRGAP2

1.51e-0425783IPR031160
DomainIntegrin_dom

ITGA10 ITGAD ITGAM

1.51e-0425783IPR032695
DomainF_BAR

SRGAP3 SRGAP1 SRGAP2

1.51e-0425783PS51741
DomainRho_GTPase_activation_prot

NF1 SRGAP3 SRGAP1 SRGAP2

5.03e-0488784IPR008936
DomainSH3_1

SRGAP3 SRGAP1 NCK1 SRGAP2 NCK2

6.18e-04164785PF00018
DomainIntegrin_alpha

ITGAD ITGAM

9.24e-0411782PF00357
DomainARM-like

DOHH NF1 ARID2 MROH7 HEATR5A CTNNB1

9.29e-04270786IPR011989
DomainVWA

ITGA10 ITGAD ITGAM

1.66e-0356783PF00092
DomainIntegrin_alpha_C_CS

ITGAD ITGAM

1.99e-0316782IPR018184
DomainSH3

SRGAP3 SRGAP1 NCK1 SRGAP2 NCK2

2.10e-03216785SM00326
DomainSH3

SRGAP3 SRGAP1 NCK1 SRGAP2 NCK2

2.10e-03216785PS50002
DomainRhoGAP

SRGAP3 SRGAP1 SRGAP2

2.22e-0362783SM00324
DomainSH3_domain

SRGAP3 SRGAP1 NCK1 SRGAP2 NCK2

2.28e-03220785IPR001452
DomainRhoGAP

SRGAP3 SRGAP1 SRGAP2

2.32e-0363783PF00620
Domain-

DOHH NF1 MROH7 HEATR5A CTNNB1

2.37e-032227851.25.10.10
DomainRHOGAP

SRGAP3 SRGAP1 SRGAP2

2.43e-0364783PS50238
DomainRhoGAP_dom

SRGAP3 SRGAP1 SRGAP2

2.43e-0364783IPR000198
Domain-

SRGAP3 SRGAP1 SRGAP2

2.43e-03647831.10.555.10
DomainARM-type_fold

DOHH NF1 ARID2 MROH7 HEATR5A CTNNB1

2.93e-03339786IPR016024
Domain-

PDK1 SMCHD1

3.12e-03207823.30.565.10
DomainHEAT_REPEAT

DOHH MROH7 HEATR5A

3.14e-0370783PS50077
DomainHATPase_C

PDK1 SMCHD1

3.43e-0321782IPR003594
DomainVWFA

ITGA10 ITGAD ITGAM

4.90e-0382783PS50234
DomainVWA

ITGA10 ITGAD ITGAM

5.24e-0384783SM00327
DomainLRR_8

LINGO1 SLITRK3 FLRT2 LRRC28

5.72e-03171784PF13855
DomainCRAL-TRIO_dom

NF1 PLEKHG4

6.07e-0328782IPR001251
DomainCys-rich_flank_reg_C

LINGO1 SLITRK3 FLRT2

6.34e-0390783IPR000483
DomainLRRCT

LINGO1 SLITRK3 FLRT2

6.34e-0390783SM00082
DomainLeu-rich_rpt_typical-subtyp

LINGO1 SLITRK3 FLRT2 LRRC28

6.45e-03177784IPR003591
DomainLRR_TYP

LINGO1 SLITRK3 FLRT2 LRRC28

6.45e-03177784SM00369
PathwayREACTOME_INACTIVATION_OF_CDC42_AND_RAC1

SRGAP3 SRGAP1 SRGAP2

4.25e-068613M27349
PathwayKEGG_AXON_GUIDANCE

EPHB6 SRGAP3 SRGAP1 NCK1 SRGAP2 NCK2

1.92e-05129616M5539
PathwayWP_GENES_CONTROLLING_NEPHROGENESIS

KDR NCK1 CTNNB1 NCK2

3.78e-0544614M39891
PathwayWP_HIPPOMERLIN_SIGNALING_DYSREGULATION

ITGA10 KDR CTNNB1 ITGAD ITGAM

1.74e-04121615M39823
PathwayKEGG_MEDICUS_REFERENCE_STEROID_HORMONE_BIOSYNTHESIS_PROGESTERONE_TO_CORTISOL_CORTISONE

CYP11B1 CYP11B2

1.83e-045612M47522
PathwayPID_INTEGRIN_CS_PATHWAY

ITGA10 ITGAD ITGAM

1.87e-0426613M47
PathwayWP_OREXIN_RECEPTOR_PATHWAY

PDK1 CYP11B1 CYP11B2 GRIN1 PPOX PDE11A

2.20e-04200616M48048
PathwayPID_VEGFR1_2_PATHWAY

KDR NCK1 CTNNB1 NCK2

2.22e-0469614M237
PathwayWP_BRAINDERIVED_NEUROTROPHIC_FACTOR_BDNF_SIGNALING

LINGO1 NCK1 GRIN1 CTNNB1 NCK2

3.90e-04144615M39691
PathwayREACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS

ITGA10 KDR ITGAD ITGAM

4.95e-0485614M16441
Pubmed

Dynamic expression of the Slit-Robo GTPase activating protein genes during development of the murine nervous system.

SRGAP3 SRGAP1 SRGAP2

1.13e-08379319137586
Pubmed

Beta-Catenin Causes Adrenal Hyperplasia by Blocking Zonal Transdifferentiation.

CYP11B1 CYP11B2 CTNNB1

4.50e-08479332320669
Pubmed

β-Catenin-Driven Differentiation Is a Tissue-Specific Epigenetic Vulnerability in Adrenal Cancer.

CYP11B1 CYP11B2 CTNNB1

4.50e-08479337129912
Pubmed

Wnt/β-catenin activation cooperates with loss of p53 to cause adrenocortical carcinoma in mice.

CYP11B1 CYP11B2 CTNNB1

4.50e-08479332561853
Pubmed

β-Catenin and FGFR2 regulate postnatal rosette-based adrenocortical morphogenesis.

CYP11B1 CYP11B2 CTNNB1

4.50e-08479332245949
Pubmed

Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.

SRGAP3 SRGAP1 NCK1 SRGAP2 NCK2

1.04e-075079519807924
Pubmed

SRGAP1 Controls Small Rho GTPases To Regulate Podocyte Foot Process Maintenance.

SRGAP3 SRGAP1 SRGAP2

2.24e-07679333514561
Pubmed

FNBP2 gene on human chromosome 1q32.1 encodes ARHGAP family protein with FCH, FBH, RhoGAP and SH3 domains.

SRGAP3 SRGAP1 SRGAP2

2.24e-07679312736724
Pubmed

Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway.

SRGAP3 SRGAP1 SRGAP2

2.24e-07679311672528
Pubmed

A ZNRF3-dependent Wnt/β-catenin signaling gradient is required for adrenal homeostasis.

CYP11B1 CYP11B2 CTNNB1

3.92e-07779330692207
Pubmed

Evidence for a role of srGAP3 in the positioning of commissural axons within the ventrolateral funiculus of the mouse spinal cord.

SRGAP3 SRGAP1 SRGAP2

3.92e-07779321655271
Pubmed

Targeting NCK-Mediated Endothelial Cell Front-Rear Polarity Inhibits Neovascularization.

KDR NCK1 NCK2

6.27e-07879326659946
Pubmed

Adipocyte-Derived Hormone Leptin Is a Direct Regulator of Aldosterone Secretion, Which Promotes Endothelial Dysfunction and Cardiac Fibrosis.

CYP11B1 CYP11B2 LEPR

9.38e-07979326362633
Pubmed

Targeted disruption of beta-catenin in Sf1-expressing cells impairs development and maintenance of the adrenal cortex.

CYP11B1 CYP11B2 CTNNB1

1.84e-061179318599507
Pubmed

Maternal corticosterone exposure in the mouse has sex-specific effects on placental growth and mRNA expression.

CYP11B1 CYP11B2 KDR

2.45e-061279322919064
Pubmed

Common polymorphisms in the CYP11B1 and CYP11B2 genes: evidence for a digenic influence on hypertension.

CYP11B1 CYP11B2

5.09e-06279223150505
Pubmed

GRAde: a long-read sequencing approach to efficiently identifying the CYP11B1/CYP11B2 chimeric form in patients with glucocorticoid-remediable aldosteronism.

CYP11B1 CYP11B2

5.09e-06279235012455
Pubmed

Role of genetic variation in regulation of aldosterone biosynthesis.

CYP11B1 CYP11B2

5.09e-06279221164264
Pubmed

Fine tuning of the threshold of T cell selection by the Nck adapters.

NCK1 NCK2

5.09e-06279221078909
Pubmed

Identification of SRGAP2 as a potential oncogene and a prognostic biomarker in hepatocellular carcinoma.

SRGAP1 SRGAP2

5.09e-06279233984363
Pubmed

The hamster adrenal cytochrome P450C11 has equipotent 11beta-hydroxylase and 19-hydroxylase activities, but no aldosterone synthase activity.

CYP11B1 CYP11B2

5.09e-0627928645611
Pubmed

Expression and localization of cytochrome P450(11beta,aldo) mRNA in the frog brain.

CYP11B1 CYP11B2

5.09e-06279212231255
Pubmed

A de novo unequal cross-over mutation between CYP11B1 and CYP11B2 genes causes familial hyperaldosteronism type I.

CYP11B1 CYP11B2

5.09e-06279220634641
Pubmed

Hereditary hypertension caused by chimaeric gene duplications and ectopic expression of aldosterone synthase.

CYP11B1 CYP11B2

5.09e-0627921303253
Pubmed

Hepsin enhances liver metabolism and inhibits adipocyte browning in mice.

HPN LEPR

5.09e-06279232404422
Pubmed

Inhibition of integrin αDβ2-mediated macrophage adhesion to end product of docosahexaenoic acid (DHA) oxidation prevents macrophage accumulation during inflammation.

ITGAD ITGAM

5.09e-06279231395659
Pubmed

Nck adaptor proteins control the organization of neuronal circuits important for walking.

NCK1 NCK2

5.09e-06279218093944
Pubmed

Nck adaptor proteins link Tks5 to invadopodia actin regulation and ECM degradation.

NCK1 NCK2

5.09e-06279219596797
Pubmed

Role of steroid 11 beta-hydroxylase and steroid 18-hydroxylase in the biosynthesis of glucocorticoids and mineralocorticoids in humans.

CYP11B1 CYP11B2

5.09e-0627921741400
Pubmed

Effects of intron conversion in the human CYP11B2 gene on its transcription and blood pressure regulation in transgenic mice.

CYP11B1 CYP11B2

5.09e-06279232540969
Pubmed

Inhibition of aldosterone synthase (CYP11B2) by torasemide prevents atrial fibrosis and atrial fibrillation in mice.

CYP11B1 CYP11B2

5.09e-06279226047574
Pubmed

Aldosterone synthase knockout mouse as a model for sodium-induced endothelial sodium channel up-regulation in vascular endothelium.

CYP11B1 CYP11B2

5.09e-06279226324851
Pubmed

A mouse model for the learning and memory deficits associated with neurofibromatosis type I.

NF1 GRIN1

5.09e-0627929054942
Pubmed

Microsatellite polymorphism analysis allows the individual assignment of the rat 11 beta-hydroxylase gene (Cyp11b1) and the rat aldosterone synthase gene (Cyp11b2) to chromosome 7 using rat x mouse somatic cell hybrids and identifies differences between and within various rat strains.

CYP11B1 CYP11B2

5.09e-0627927669222
Pubmed

Slit-Robo GTPase-activating proteins are differentially expressed in murine dorsal root ganglia: modulation by peripheral nerve injury.

SRGAP3 SRGAP1

5.09e-06279222271578
Pubmed

Aldosterone-dependent and -independent regulation of the epithelial sodium channel (ENaC) in mouse distal nephron.

CYP11B1 CYP11B2

5.09e-06279222933298
Pubmed

Structural and functional analysis of the promoter region of the gene encoding mouse steroid 11 beta-hydroxylase.

CYP11B1 CYP11B2

5.09e-0627922783417
Pubmed

Cloning and expression of a cDNA for human cytochrome P-450aldo as related to primary aldosteronism.

CYP11B1 CYP11B2

5.09e-0627922256920
Pubmed

Association of DNA polymorphisms within the CYP11B2/CYP11B1 locus and postoperative hypertension risk in the patients with aldosterone-producing adenomas.

CYP11B1 CYP11B2

5.09e-06279220708777
Pubmed

Molecular genetic studies on the biosynthesis of aldosterone in humans.

CYP11B1 CYP11B2

5.09e-06279222217843
Pubmed

Mechanistic study of polychlorinated biphenyl 126-induced CYP11B1 and CYP11B2 up-regulation.

CYP11B1 CYP11B2

5.09e-06279216396990
Pubmed

The inverse F-BAR domain protein srGAP2 acts through srGAP3 to modulate neuronal differentiation and neurite outgrowth of mouse neuroblastoma cells.

SRGAP3 SRGAP2

5.09e-06279223505444
Pubmed

Nck adaptors are positive regulators of the size and sensitivity of the T-cell repertoire.

NCK1 NCK2

5.09e-06279220709959
Pubmed

[123 I]Iodometomidate for molecular imaging of adrenocortical cytochrome P450 family 11B enzymes.

CYP11B1 CYP11B2

5.09e-06279218397978
Pubmed

Glucocorticoid-suppressible hyperaldosteronism results from hybrid genes created by unequal crossovers between CYP11B1 and CYP11B2.

CYP11B1 CYP11B2

5.09e-0627921518866
Pubmed

Endothelial NCK2 promotes atherosclerosis progression in male but not female Nck1-null atheroprone mice.

NCK1 NCK2

5.09e-06279236035930
Pubmed

Procollagen I-expressing renin cell precursors.

CYP11B1 CYP11B2

5.09e-06279223761669
Pubmed

Characterization of two genes encoding human steroid 11 beta-hydroxylase (P-450(11) beta).

CYP11B1 CYP11B2

5.09e-0627922592361
Pubmed

High glucose-ROS conditions enhance the progression in cholangiocarcinoma via upregulation of MAN2A2 and CHD8.

MAN2A2 CHD8

5.09e-06279233141432
Pubmed

Aldosterone deficiency prevents high-fat-feeding-induced hyperglycaemia and adipocyte dysfunction in mice.

CYP11B1 CYP11B2

5.09e-06279223314847
Pubmed

Effect of variation in CYP11B1 and CYP11B2 on corticosteroid phenotype and hypothalamic-pituitary-adrenal axis activity in hypertensive and normotensive subjects.

CYP11B1 CYP11B2

5.09e-06279217980006
Pubmed

Association between aldosterone production and variation in the 11beta-hydroxylase (CYP11B1) gene.

CYP11B1 CYP11B2

5.09e-06279216984984
Pubmed

Evidence for local aldosterone synthesis in the large intestine of the mouse.

CYP11B1 CYP11B2

5.09e-06279235288482
Pubmed

Homeostatic responses in the adrenal cortex to the absence of aldosterone in mice.

CYP11B1 CYP11B2

5.09e-06279215731365
Pubmed

A novel beta-catenin-binding protein inhibits beta-catenin-dependent Tcf activation and axis formation.

CHD8 CTNNB1

5.09e-06279210921920
Pubmed

Distinct Requirements for Adaptor Proteins NCK1 and NCK2 in Mammary Gland Development.

NCK1 NCK2

5.09e-06279237479911
Pubmed

Phenotypic consequences of variation across the aldosterone synthase and 11-beta hydroxylase locus in a hypertensive cohort: data from the MRC BRIGHT Study.

CYP11B1 CYP11B2

5.09e-06279217651452
Pubmed

Expression of CYP11B1 and CYP11B2 in adrenal adenoma correlates with clinical characteristics of primary aldosteronism.

CYP11B1 CYP11B2

5.09e-06279234743356
Pubmed

Polymorphisms in CYP11B2 and CYP11B1 genes associated with primary hyperaldosteronism.

CYP11B1 CYP11B2

5.09e-06279220339375
Pubmed

Genetic analyses of the chimeric CYP11B1/CYP11B2 gene in a Korean family with glucocorticoid-remediable aldosteronism.

CYP11B1 CYP11B2

5.09e-06279220808686
Pubmed

Pharmacologically targeting beta-catenin for NF1 associated deficiencies in fracture repair.

NF1 CTNNB1

5.09e-06279228254468
Pubmed

Non-compensating roles between Nckalpha and Nckbeta in PDGF-BB signaling to promote human dermal fibroblast migration.

NCK1 NCK2

5.09e-06279219242519
Pubmed

Dissection of Glomerular Transcriptional Profile in Patients With Diabetic Nephropathy: SRGAP2a Protects Podocyte Structure and Function.

SRGAP2 LEPR

5.09e-06279229242313
Pubmed

Aldosterone decreases glucose-stimulated insulin secretion in vivo in mice and in murine islets.

CYP11B1 CYP11B2

5.09e-06279221519965
Pubmed

Diagnosis of glucocorticoid-remediable aldosteronism in hypertensive children.

CYP11B1 CYP11B2

5.09e-06279221625068
Pubmed

Genetic screening for glucocorticoid-remediable aldosteronism (GRA): experience of three clinical centres in Poland.

CYP11B1 CYP11B2

5.09e-06279216110193
Pubmed

Chimeric CYP11B2/CYP11B1 causing 11β-hydroxylase deficiency in Chinese patients with congenital adrenal hyperplasia.

CYP11B1 CYP11B2

5.09e-06279226066897
Pubmed

[A uNick protein].

NCK1 NCK2

5.09e-06279221880263
Pubmed

Nck adaptor proteins modulate differentiation and effector function of T cells.

NCK1 NCK2

5.09e-06279225995205
Pubmed

Nck influences preosteoblastic/osteoblastic migration and bone mass.

NCK1 NCK2

5.09e-06279226621720
Pubmed

Cytotoxicity and decreased corticosterone production in adrenocortical Y-1 cells by 3-methylsulfonyl-DDE and structurally related molecules.

CYP11B1 CYP11B2

5.09e-06279218651133
Pubmed

A new presentation of the chimeric CYP11B1/CYP11B2 gene with low prevalence of primary aldosteronism and atypical gene segregation pattern.

CYP11B1 CYP11B2

5.09e-06279222083159
Pubmed

Editorial: polymorphisms in CYP11B genes and 11-hydroxylase activity.

CYP11B1 CYP11B2

5.09e-06279215699546
Pubmed

Cyp11b1 is induced in the murine gonad by luteinizing hormone/human chorionic gonadotropin and involved in the production of 11-ketotestosterone, a major fish androgen: conservation and evolution of the androgen metabolic pathway.

CYP11B1 CYP11B2

5.09e-06279218162527
Pubmed

Chronic activation of adrenal Gq signaling induces Cyp11b2 expression in the zona fasciculata and hyperaldosteronism.

CYP11B1 CYP11B2

5.09e-06279238341019
Pubmed

Adrenal CYP11B1/2 expression in primary aldosteronism: immunohistochemical analysis using novel monoclonal antibodies.

CYP11B1 CYP11B2

5.09e-06279224837548
Pubmed

Aldosterone deficiency in mice burdens respiration and accentuates diet-induced hyperinsulinemia and obesity.

CYP11B1 CYP11B2

5.09e-06279230046010
Pubmed

Familial and phenotypic associations of the aldosterone Renin ratio.

CYP11B1 CYP11B2

5.09e-06279219820005
Pubmed

Downregulation of TET1 Promotes Glioma Cell Proliferation and Invasion by Targeting Wnt/β-Catenin Pathway.

TET1 CTNNB1

5.09e-06279234926132
Pubmed

Aldosterone deficiency and mineralocorticoid receptor antagonism prevent angiotensin II-induced cardiac, renal, and vascular injury.

CYP11B1 CYP11B2

5.09e-06279222622494
Pubmed

Mutation analysis of CYP11B1 and CYP11B2 in patients with increased 18-hydroxycortisol production.

CYP11B1 CYP11B2

5.09e-06279215062555
Pubmed

Disturbed homeostasis in sodium-restricted mice heterozygous and homozygous for aldosterone synthase gene disruption.

CYP11B1 CYP11B2

5.09e-06279217075030
Pubmed

Polymorphic variation in the 11beta-hydroxylase gene associates with reduced 11-hydroxylase efficiency.

CYP11B1 CYP11B2

5.09e-06279217075029
Pubmed

CYP11B2-CYP11B1 haplotypes associated with decreased 11 beta-hydroxylase activity.

CYP11B1 CYP11B2

5.09e-06279215507509
Pubmed

Polymorphism of CYP11B2 determines salt sensitivity in Japanese.

CYP11B1 CYP11B2

5.09e-06279217296872
Pubmed

Salt-sensitive blood pressure in mice with increased expression of aldosterone synthase.

CYP11B1 CYP11B2

5.09e-06279218039983
Pubmed

Cyp11b1 null mouse, a model of congenital adrenal hyperplasia.

CYP11B1 CYP11B2

5.09e-06279219029289
Pubmed

The phosphotyrosine peptide binding specificity of Nck1 and Nck2 Src homology 2 domains.

NCK1 NCK2

5.09e-06279216636066
Pubmed

Necl-4 enhances the PLCγ-c-Raf-MEK-ERK pathway without affecting internalization of VEGFR2.

CADM4 KDR

5.09e-06279228601637
Pubmed

Genetic variation at the locus encompassing 11-beta hydroxylase and aldosterone synthase accounts for heritability in cortisol precursor (11-deoxycortisol) urinary metabolite excretion.

CYP11B1 CYP11B2

5.09e-06279215522937
Pubmed

Vegfa regulates perichondrial vascularity and osteoblast differentiation in bone development.

KDR CTNNB1 IHH

8.98e-061879325977369
Pubmed

Nck-1 antagonizes the endoplasmic reticulum stress-induced inhibition of translation.

NCK1 NCK2

1.53e-05379214676213
Pubmed

The roles of cAMP and cAMP-dependent protein kinase in the expression of cholesterol side chain cleavage and steroid 11 beta-hydroxylase genes in mouse adrenocortical tumor cells.

CYP11B1 CYP11B2

1.53e-0537922546938
Pubmed

Kidney function in mice lacking aldosterone.

CYP11B1 CYP11B2

1.53e-05379216118390
Pubmed

Identification and functional characterization of a novel human misshapen/Nck interacting kinase-related kinase, hMINK beta.

NCK1 CTNNB1

1.53e-05379215469942
Pubmed

Cooperative Interaction of Nck and Lck Orchestrates Optimal TCR Signaling.

NCK1 NCK2

1.53e-05379233917227
Pubmed

Nck adaptors, besides promoting N-WASP mediated actin-nucleation activity at pedestals, influence the cellular levels of enteropathogenic Escherichia coli Tir effector.

NCK1 NCK2

1.53e-05379225482634
Pubmed

Aldosterone-induced coronary dysfunction in transgenic mice involves the calcium-activated potassium (BKCa) channels of vascular smooth muscle cells.

CYP11B1 CYP11B2

1.53e-05379217984374
Pubmed

A Study of Interleukin-2 Production and Nck Adaptor Molecule Gene Expression in Systemic Lupus Erythematosus Patients.

NCK1 NCK2

1.53e-05379229911835
Pubmed

Identification and characterization of two upstream elements that regulate adrenocortical expression of steroid 11 beta-hydroxylase.

CYP11B1 CYP11B2

1.53e-0537922233742
CytobandEnsembl 112 genes in cytogenetic band chr2q35

ABCA12 IHH USP37

1.47e-03129793chr2q35
Cytoband15q26.3

SYNM LRRC28

2.30e-034179215q26.3
GeneFamilyCD molecules|Integrin alpha subunits

ITGA10 ITGAD ITGAM

2.60e-05185931160
GeneFamilyCytochrome P450 family 11

CYP11B1 CYP11B2

3.13e-0535921007
GeneFamilyRho GTPase activating proteins|F-BAR domain containing

SRGAP3 SRGAP1 SRGAP2

5.58e-05235931288
GeneFamilyRho GTPase activating proteins|BCH domain containing

SRGAP3 SRGAP1 SRGAP2

5.80e-0450593721
ToppCell(6)_Endothelial_cells-(6)_Endothelial-F_(Lymphatics)|(6)_Endothelial_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)

HP SYNM SRGAP3 GBGT1 FLRT2 CGNL1

1.27e-061947969441202d6fa2ffbef9277d48ae9bc98876c26ec5
ToppCell390C-Endothelial_cells-Endothelial-F_(Lymphatics)-|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

HP SYNM SRGAP3 GBGT1 FLRT2 CGNL1

1.39e-06197796c84e988c2ad06087aafda9e3b68e9e72fd0e75f1
ToppCell390C-Endothelial_cells-Endothelial-F_(Lymphatics)|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

HP SYNM SRGAP3 GBGT1 FLRT2 CGNL1

1.39e-061977966195f945b3fd6da07907619267d49e96d1044f8f
ToppCell3'-GW_trimst-1.5-SmallIntestine-Mesenchymal-stromal_related-ICC|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SYNM ITGA10 CGNL1 SPAG17 PCDH17

1.13e-05165795b1bbf5acdfc52bd8c7c7eb356d73b812eb6b908c
ToppCell3'-GW_trimst-1.5-SmallIntestine-Mesenchymal-stromal_related|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SYNM ITGA10 CGNL1 SPAG17 PCDH17

1.13e-0516579528f8297ec7b781149cc7ac2f5e441771083b8ee3
ToppCelldroplet-Lung-30m-Hematologic-myeloid-plasmacytoid_dendritic_cell|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SRGAP3 CHDH TET1 CGNL1 MUC5AC

1.42e-051737954f0c065e876197ad8cae7856669f09e37ecafa3f
ToppCelldroplet-Lung-30m-Hematologic-myeloid-plasmacytoid_dendritic_cell-plasmacytoid_dendritic|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SRGAP3 CHDH TET1 CGNL1 MUC5AC

1.42e-051737959bbea566964281f47bf75d665b7d69ba8326e207
ToppCelldroplet-Liver-LIVER_NPC-30m-Endothelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RALGPS2 ITGA10 KDR ATP11A NCK2

1.67e-05179795025d414ec88d5680d99c8173e70ee3bb0b694f74
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPHB6 SRGAP3 FAT3 RALGPS2 GRIN1

1.67e-05179795479116ac65488c60104a053530830763ec1f95b2
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPHB6 SRGAP3 FAT3 RALGPS2 GRIN1

1.67e-051797951dfc0cb8b369aef35c59f3d4c52603dc9f3728c1
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPHB6 SRGAP3 FAT3 RALGPS2 GRIN1

1.67e-0517979569a1b3b05c921de6343ffe6ad998aa2b804312a7
ToppCelldroplet-Liver-nan-3m-Endothelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARID2 SRGAP1 RALGPS2 ATP11A PCDH17

1.77e-05181795fcc94f04dae98b817ec06b282d2e887804d37ae5
ToppCellControl-Endothelial-Endothelial-Activated_Alv_Cap|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SRGAP1 CHDH KDR INPP4B PCDH17

1.86e-05183795e81c142770f44fd902b0631bc360c5b5339d4c75
ToppCellwk_15-18-Epithelial-Distal_epithelial_progenitor-epi-tip_intermediate|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

CELSR1 HPN ZNF335 ATP11A IHH

1.96e-05185795636505a3d96f75d951ab42bcf8af6ae07abc732d
ToppCellCOVID-19-Heart-EC_(POSTN)|Heart / Disease (COVID-19 only), tissue and cell type

ITGA10 FLRT2 CGNL1 LEPR PCDH17

2.34e-05192795c0c34785a7bdf461722029b322e9184e3d9b3c26
ToppCell343B-Endothelial_cells-Endothelial-F_(Lymphatics)-|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

HP SYNM SRGAP3 FLRT2 CGNL1

2.52e-05195795fc75f04eb475c8139cc5c35e6be22e73fb2be9e6
ToppCell343B-Endothelial_cells-Endothelial-F_(Lymphatics)|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

HP SYNM SRGAP3 FLRT2 CGNL1

2.52e-0519579583d45ff5e5bc704448431149fffb2e4c1278f279
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_secretory|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CELSR1 SRGAP3 KDR MUC5AC INPP4B

2.72e-05198795af399569c718f5fd971d73a7926768c9311002a3
ToppCellBiopsy_Other_PF-Epithelial-AT2|Biopsy_Other_PF / Sample group, Lineage and Cell type

HPN ATP11A CGNL1 SEZ6L2 DCBLD2

2.78e-051997959a65acfe9bf500db72142469cf17bf0973540001
ToppCellLPS_IL1RA_TNF-Epithelial_alveolar-AT_1|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

CELSR1 HPN ATP11A HEATR5A CGNL1

2.78e-051997951c70e7d6bd25980e1b92aa1cac3f3c95d9651b4b
ToppCellLPS_IL1RA-Epithelial_alveolar-AT_1|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

CELSR1 HPN ATP11A HEATR5A CGNL1

2.78e-05199795a270630626df614f8605abddb7dee7c4d74f6149
ToppCell5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.3.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

HPN ATP11A CGNL1 SEZ6L2 DCBLD2

2.78e-051997952dc33804f6691d7c9682e6c9b885e945fb97fc36
ToppCellTransplant_Alveoli_and_parenchyma-Mesenchymal-Mesothelium|Mesenchymal / Tissue, Lineage and Cell class of Lung Cells from 10X

EPHB6 HP FLRT2 SEZ6L2 DCBLD2

2.78e-051997956cfefd81e8a1a883fb4279ac4ab0b298ed2a0817
ToppCellBrain_organoid-organoid_Paulsen_bioRxiv-3_mon-Neuronal|3_mon / Sample Type, Dataset, Time_group, and Cell type.

LINGO1 SRGAP1 ACTL6B FLRT2 SEZ6L2

2.78e-051997951029f3458b7fda464aa0e7ef06e081e2618c1388
ToppCellBrain_organoid-organoid_Paulsen_bioRxiv-3_mon-Neuronal-PNs|3_mon / Sample Type, Dataset, Time_group, and Cell type.

LINGO1 SRGAP1 ACTL6B FLRT2 SEZ6L2

2.78e-051997958a04398653a1794921d73a6a950c1fb6fdf68c85
ToppCellTracheal-NucSeq-Stromal-Fibroblastic-Fibro_perichondrial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

HP ITGA10 KDR FLRT2 LEPR

2.85e-05200795a4ec0e80f5422b91b85264a9bb74568dd577e285
ToppCellGlobus_pallidus|World / BrainAtlas - Mouse McCarroll V32

PLEKHG4 ITGA10 MROH7 PPOX

7.49e-0512679444b63f945d5bedf1a2ca1810e7e100276ea9dd89
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L6_IT-L6_IT_VISp_Car3|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SYNM CGNL1 IHH LEPR

9.51e-051347944ef5f395e321cf04e56560be2502a8aa157682f4
ToppCellSubstantia_nigra-Macroglia-POLYDENDROCYTE-P1-P1_1-Trf-Oligodendrocyte.Tfr.Ctps_(Ctps)|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

KIF2B ITGAD ADGRG4

1.28e-04557930b62b4f438a493a30bddb99e1eadd20c92704ee9
ToppCellSubstantia_nigra-Macroglia-POLYDENDROCYTE-P1-P1_1-Trf|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

KIF2B ITGAD ADGRG4

1.28e-0455793fa556ea954ea868a4b23e410f3b27d69e04794ee
ToppCell3'_v3-bone_marrow-Lymphocytic_Invariant-Inducer-like-ILC3|bone_marrow / Manually curated celltypes from each tissue

SRGAP3 HPN CHDH MROH7

1.43e-04149794d7f1069f70f3cad6d3700ee2041ed1d4cb7c49ab
ToppCell343B-Myeloid-Macrophage-SPP1+_Macrophage|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

RALGPS2 ITGA10 KDR LEPR

1.79e-04158794de65af8d3b8514b17978155f31975e2347b75251
ToppCellClub-club-16|World / Class top

DHX32 GRIN1 PCDH17 NCK2

2.12e-04165794684f3c4872bd630d3f744f15d57dccfd34e96160
ToppCell15-Airway-Mesenchymal-Airway_Smooth_Muscle|Airway / Age, Tissue, Lineage and Cell class

SYNM FAT3 ITGA10 SLITRK3

2.12e-04165794531804467601e1ee1f771cffa21501f6d464ae10
ToppCellcontrol-Epithelial-Ionocyte|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

PDK1 FAT3 CGNL1 PDE11A

2.12e-041657945cfba9a46bd8ceeca74a6493057b4d38af6b06fe
ToppCellcontrol-Epithelial-Ionocyte|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

PDK1 FAT3 CGNL1 PDE11A

2.27e-04168794327b02f19f4a8607c033203824fdc60a1254331f
ToppCellfacs-Marrow-Granulocytes-24m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DHRS11 FAT3 CAPN5 SNX22

2.37e-04170794b180ec9a1b79025a180c8559c27c31272410dea8
ToppCelldroplet-Lung-nan-18m-Myeloid-Plasmacytoid_Dendritic|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SRGAP3 CHDH ITGAD MUC5AC

2.37e-04170794749144a1a869a6bf9acdd227184319083367dc3f
ToppCellfacs-Marrow-Granulocytes-24m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DHRS11 FAT3 CAPN5 SNX22

2.37e-0417079437c647f67505aa1ff12a198df1eeddd9f406fe15
ToppCelldroplet-Lung-nan-18m-Myeloid-plasmacytoid_dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SRGAP3 CHDH ITGAD MUC5AC

2.37e-0417079425d60a62e8f99c31ab64fe6a0c07ccca3df1a7ee
ToppCelldroplet-Lung-18m-Hematologic-myeloid-plasmacytoid_dendritic_cell-plasmacytoid_dendritic|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SRGAP3 CHDH ITGAD MUC5AC

2.48e-04172794422d311bba2dd5d8bece4e96ee8c86e78086b62d
ToppCelldroplet-Lung-18m-Hematologic-myeloid-plasmacytoid_dendritic_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SRGAP3 CHDH ITGAD MUC5AC

2.48e-041727941abb6fbb28c8aff384540493d0f70eeacaa751f4
ToppCellfacs-Pancreas-Exocrine-18m-Epithelial|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HPN FAT3 CGNL1 SNX22

2.65e-041757943f1b2e23fec953148fb0711e523c463adb07dca4
ToppCelldroplet-Lung-immune-endo-depleted-3m-Myeloid-Myeloid_Dendritic_Type_2|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THOP1 SRGAP3 TET1 SLC25A19

2.65e-04175794bb058e714d21a0ec8532eaf3c7dd2faf78016bc0
ToppCellControl-B_cells|Control / group, cell type (main and fine annotations)

PDK1 SMCHD1 RALGPS2 STEAP1B

2.70e-041767949125caa27bf790f6b1b960a86c09b4bcb1b58641
ToppCellnucseq-Epithelial-Epithelial_Airway-Secretory/RAS|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CELSR1 SRGAP3 KDR MUC5AC

2.76e-04177794779ba86f53650772755b52460be03f18bb204e55
ToppCellnucseq-Epithelial-Epithelial_Airway-Secretory/RAS-Secretory|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CELSR1 SRGAP3 KDR MUC5AC

2.76e-041777940f210cfb61b873c5fd77dc17eadf4d017306500e
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.5|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SRGAP3 SRGAP1 UPF1 MUC5AC

2.88e-041797946e965e424eebef50f0202cff75f458be395cfca1
ToppCellfacs-Pancreas-Exocrine-18m|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HPN FAT3 CGNL1 SNX22

2.88e-04179794bbfbfb32773346080127055b5aafa36bbf7d0942
ToppCellNS-critical-LOC-Epithelial-Ionocyte|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

FAT3 GRIN1 CGNL1 PDE11A

2.88e-0417979465a96bee7bc28f5bfc20f0fd92bcc0ab2eb5e06c
ToppCell367C-Endothelial_cells-Endothelial-F_(Lymphatics)-|367C / Donor, Lineage, Cell class and subclass (all cells)

SYNM SRGAP3 KDR FLRT2

3.01e-04181794b244ecaa442bbef51289d8ec574ef08fa9e96318
ToppCellPND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LINGO1 CADM4 FLRT2 CGNL1

3.01e-04181794330d4322f4c4373f706273c1f4e218b59051b7fd
ToppCellfacs-Marrow-B-cells-18m-Myeloid-CD4+_macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SRGAP3 CHDH ITGAD ATP13A2

3.01e-04181794782716b8b1d447d2bbe09a693fa5ed7ebeac0efb
ToppCell367C-Endothelial_cells-Endothelial-F_(Lymphatics)|367C / Donor, Lineage, Cell class and subclass (all cells)

SYNM SRGAP3 KDR FLRT2

3.01e-04181794dd79de8098edb385a0f85d0e9621503cdf76ec43
ToppCellfacs-Marrow-B-cells-18m-Myeloid-macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SRGAP3 CHDH ITGAD ATP13A2

3.01e-04181794e2481291c236105774c53883e6f20da11941df9b
ToppCellHSPCs-Erythroblasts|World / Lineage and Cell class

HPN DHRS11 KLHL12 PPOX

3.01e-04181794ce26f1accc8f69b7bc4b929073e975c887566c6a
ToppCellPND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LINGO1 CADM4 FLRT2 CGNL1

3.01e-041817943f4d5d79c1286614514b0e8134079d6128a2a23e
ToppCellnormal_Lung-B_lymphocytes-Follicular_B_cells|normal_Lung / Location, Cell class and cell subclass

SMCHD1 RALGPS2 STEAP1B SNX22

3.07e-0418279413c39228f76495deca6b948483bbde426b3e8c5b
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_VWA2|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CELSR1 CGNL1 PCDH17 NCK2

3.07e-0418279472e65a23cd36085bc880087d3cae92395de918a1
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CELSR1 CGNL1 PCDH17 NCK2

3.07e-0418279405c167158815bf25d509df59ab386e1990712765
ToppCelldroplet-Limb_Muscle-Pre-Sort-18m-Macroglial-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CELSR1 LINGO1 CADM4 SLITRK3

3.07e-04182794c00e503f442d44fbae73c5e2dc85be69e294e67a
ToppCell(6)_Endothelial-F_(Lymphatics)|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

SYNM SRGAP3 KDR FLRT2

3.20e-0418479403ea613e00b45c81b752c14505a0538d698f551e
ToppCellEndothelial-A-Donor_01|World / lung cells shred on cell class, cell subclass, sample id

PDZD9 KDR LEPR PCDH17

3.34e-04186794796cbae2a417502aaf0891fc9c382bbfd88967fe
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

EPHB6 LINGO1 FAT3 FLRT2

3.34e-04186794bdbe290f81106a53c8c30a92fbb385597c62b2ac
ToppCell343B-Endothelial_cells-Endothelial-F_(Lymphatics)|343B / Donor, Lineage, Cell class and subclass (all cells)

SYNM SRGAP3 KDR FLRT2

3.34e-041867947a8da2ad140bea3207bd868212cc5e201d586772
ToppCell343B-Endothelial_cells-Endothelial-F_(Lymphatics)-|343B / Donor, Lineage, Cell class and subclass (all cells)

SYNM SRGAP3 KDR FLRT2

3.34e-04186794dc394034929c6b10ae0e1c1a028cc3d4ce873298
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1|TCGA-Pancreas / Sample_Type by Project: Shred V9

ARID2 SMCHD1 HEATR5A USP37

3.34e-0418679403db813598b67b1e08f759758a1c2023396921fa
ToppCellAdult-Epithelial-club_cell-D231|Adult / Lineage, Cell type, age group and donor

CELSR1 SRGAP3 KDR INPP4B

3.40e-04187794ee59d7d3de5879738ff0b9c3ea5e4847fb48cb86
ToppCellLV-10._Endothelium_II|World / Chamber and Cluster_Paper

LINGO1 ITGA10 CGNL1 LEPR

3.40e-041877947876dcb4800c2e54874df3d933efb79307a64a97
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CELSR1 HPN CHDH CGNL1

3.40e-041877943ae3b8de1a195d4d5057cf3c64fcdb5f48681ce5
ToppCell10x3'2.3-week_12-13-Lymphocytic_NK-T_NK-ILC_precursor|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

SRGAP3 HPN KDR INPP4B

3.40e-04187794f31d865ce2a21bdf64dbe29ee3e4505ab482604a
ToppCellTCGA-Kidney-Primary_Tumor-Renal_Cell_Carcinoma-Kidney_Clear_Cell_Renal_Carcinoma|TCGA-Kidney / Sample_Type by Project: Shred V9

LINGO1 PDK1 KDR PCDH17

3.47e-04188794e711c7a46d7cfa030ca2982eacc1dae5af5788dd
ToppCell5'-Airway_Nasal-Endothelial-Blood_vessel_EC-vein_endothelial_cell|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PLEKHG4 ITGA10 CHD8 PCDH17

3.47e-04188794524d1d928c9386acf20e53d31894107dd7290dc7
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

NF1 ARID2 SMCHD1 CTNNB1

3.47e-04188794ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell5'-Airway_Nasal-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_systemic-EC_venous_systemic_L.2.2.0.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PLEKHG4 ITGA10 CHD8 PCDH17

3.47e-041887941b57995d70cf81212e8d46dfaf44dbaf9c7bc4d5
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_B-B_cell-B_c02-MS4A1-CD27|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

CELSR1 RALGPS2 STEAP1B SNX22

3.47e-041887945707786cc4452dc34f95db2b3cd29f6e025c0622
ToppCell5'-Airway_Nasal-Endothelial-Blood_vessel_EC|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PLEKHG4 ITGA10 CHD8 PCDH17

3.47e-04188794cd2d1f8e43c252dd8730a5758458ef63e7ffc836
ToppCell343B-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)-|343B / Donor, Lineage, Cell class and subclass (all cells)

SYNM ITGA10 KDR PCDH17

3.47e-04188794fe7143c36e4a883745862d3c3147cf751b440e46
ToppCellEndothelial-B-IPF_03|World / lung cells shred on cell class, cell subclass, sample id

SYNM SRGAP3 NUP98 FLRT2

3.47e-04188794ecb74d67314a43b5805b7f2a7bb9ff6c5a60200a
ToppCell5'-Airway_Nasal-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_systemic|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PLEKHG4 ITGA10 CHD8 PCDH17

3.47e-04188794f5a2f324f3f6c5078d57130392d3f1ba74f29094
ToppCell343B-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)|343B / Donor, Lineage, Cell class and subclass (all cells)

SYNM ITGA10 KDR PCDH17

3.47e-04188794cbf32b675a7cd0c808d5c9c22dfa7fa79fbe2437
ToppCell5'-Airway_Nasal-Endothelial|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PLEKHG4 ITGA10 CHD8 PCDH17

3.47e-041887946c9d5e4014f807149328ff4eabd5e86dfe18094d
ToppCellCOPD-Epithelial-Mesothelial|Epithelial / Disease state, Lineage and Cell class

EPHB6 HP SRGAP1 FLRT2

3.47e-04188794159d63ecc3653a7449fc6acefd6ef0464845260e
ToppCelltumor_Lung-Fibroblasts-Pericytes|Fibroblasts / Location, Cell class and cell subclass

LINGO1 SYNM INPP4B NCK2

3.54e-041897949c407b17d7945e81e1ae6c18452f5d20fb09d563
ToppCellIPF-Endothelial-VE_Capillary_A|World / Disease state, Lineage and Cell class

SYNM ITGA10 KDR PCDH17

3.54e-04189794ea3aa3ef38f1d405bb527ae383cd12c551a3dd6f
ToppCellfacs-Skin-Anagen|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CTNNB1 ATP13A2 DDX1 NCK2

3.54e-04189794adbfc723130079b4caf551f66d2aee86fab1903c
ToppCelldroplet-Heart-nan-24m-Endothelial-endocardial_endothelial_cells|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CELSR1 RALGPS2 FLRT2 CGNL1

3.54e-041897941137583e21d874c201c20581ba1995e2bfa3de59
ToppCellAdult-Epithelial-club_cell|Adult / Lineage, Cell type, age group and donor

CELSR1 SRGAP3 KDR INPP4B

3.62e-04190794756bff697d30aec56c0ebfca94295f084a15bf37
ToppCelldroplet-Heart-nan-24m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CELSR1 RALGPS2 FLRT2 CGNL1

3.62e-041907947068754c29f63a331e2b6c54715f3b26f37ad32b
ToppCellIPF-Endothelial-VE_Capillary_A|IPF / Disease state, Lineage and Cell class

SYNM ITGA10 KDR PCDH17

3.62e-04190794b4e35cbfe4d43d2cd51f29c3085e4d9b1012e6f0
ToppCellfacs-Mammary_Gland-Mammary_Gland-21m-Epithelial-luminal_progenitor_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LINGO1 HP CADM4 DHX32

3.62e-041907940bad41d19dc515e6bc61e699f4d56664cf2e72fd
ToppCellControl-Endothelial-VE_Capillary_B|World / Disease state, Lineage and Cell class

ITGA10 KDR LEPR PCDH17

3.69e-04191794c672c8e28d06d555335976b3f8bd2ea6d3b34aae
ToppCellControl-Endothelial-VE_Capillary_B|Control / Disease state, Lineage and Cell class

ITGA10 KDR LEPR PCDH17

3.69e-04191794322237793a1278bafb14e63cab688b353e352dcc
ToppCelldroplet-Heart-HEART-1m-Endothelial-endothelial_cell_of_coronary_artery|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KDR CTNNB1 SEZ6L2 PCDH17

3.69e-041917941aac4f839c2f83dac924fdb5d8d0c76687dacd2a
ToppCellLA-05._Cytoplasmic_Cardiomyocyte_I|World / Chamber and Cluster_Paper

EPHB6 LINGO1 HP STEAP1B

3.69e-04191794d825e55278dce666c332cc060d1255659e07e568
ToppCell(1)_Osterolineage_cells-(10)_OLC-1|(1)_Osterolineage_cells / Cell class and subclass of bone marrow stroma cells in homeostatis

HP FAT3 CTNNB1 LEPR

3.69e-0419179478ad7c555409ce1391bce406bc0f3ef575329ece
ToppCell10x3'2.3-week_14-16-Endothelial-stroma-immature_EC|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

SYNM SRGAP1 KDR FLRT2

3.76e-041927945af3b2b38495e925497c48f605d618bbf970965d
ToppCell5'-GW_trimst-1.5-SmallIntestine-Mesenchymal-stromal_related|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SYNM ITGA10 CGNL1 PCDH17

3.76e-041927948ad6678df89175c5a4a835c8566f1552df3c996e
ToppCelldroplet-Heart-HEART-1m-Endothelial-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KDR CTNNB1 SEZ6L2 PCDH17

3.76e-041927949da21ce330f3b5661f159cf18d1c3e5ccc11d6dd
ToppCellPBMC-Control-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-0|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CELSR1 RALGPS2 STEAP1B SNX22

3.76e-0419279489b8ebdc285ed3c0f807fd1157271130d37dfa41
DrugEthopropazine hydrochloride [1094-08-2]; Up 200; 11.4uM; MCF7; HT_HG-U133A

EPHB6 NF1 SRGAP3 CYP11B1 FLRT2 MUC5AC DCBLD2

5.13e-061977873376_UP
Drugdeguelin

PDK1 NUP98 KDR CTNNB1 IHH ITGAM

7.65e-06137786ctd:C107676
Drug3,4,5,3',4',5'-hexachlorobiphenyl

CYP11B1 CYP11B2 KDR

1.08e-0513783ctd:C027309
Drugcyadox

CYP11B1 CYP11B2

1.16e-052782ctd:C020728
Drug18-hydroxydeoxycorticosterone

CYP11B1 CYP11B2

1.16e-052782ctd:C042509
Drug1y0l

HP HPN NCK1

3.04e-0518783CID000657047
Drug18-hydroxycortisol

CYP11B1 CYP11B2

3.47e-053782ctd:C033689
DrugPinacidil [85371-64-8]; Down 200; 16.4uM; MCF7; HT_HG-U133A

NF1 PDK1 RALGPS2 NUP98 ITGA10 CAPN5

5.01e-051917865456_DN
DrugIndapamide [26807-65-8]; Down 200; 10.6uM; MCF7; HT_HG-U133A

EPHB6 NF1 RALGPS2 CTNNB1 DCBLD2 LEPR

5.47e-051947863859_DN
DrugGlafenine hydrochloride [65513-72-6]; Down 200; 9.8uM; PC3; HT_HG-U133A

THOP1 SLC39A9 NUP98 CAPN5 ATP13A2 INPP4B

5.79e-051967867257_DN
DrugTetracycline hydrochloride [64-75-5]; Up 200; 8.4uM; MCF7; HT_HG-U133A

SRGAP3 CADM4 KDR IHH ITGAM MUC5AC

5.79e-051967862243_UP
DrugTetracycline hydrochloride [64-75-5]; Up 200; 8.4uM; MCF7; HT_HG-U133A

CELSR1 NF1 HPN RALGPS2 NUP98 LEPR

5.95e-051977866233_UP
DrugPhenylpropanolamine hydrochloride [154-41-6]; Up 200; 21.4uM; PC3; HT_HG-U133A

MAN2A2 NF1 SRGAP3 DHRS11 RALGPS2 UPF1

6.29e-051997866699_UP
DrugICI182,780; Up 200; 1uM; MCF7; HT_HG-U133A

DOHH NF1 ABCA12 HPN ATP11A LEPR

6.29e-051997866872_UP
DrugF-OH

NF1 SRGAP1 SRGAP2 LEPR

6.51e-0563784CID000123334
Drugmethenamine silver

CELSR1 SRGAP3 SRGAP1 ACTL6B SRGAP2 IHH

6.65e-05201786CID000004101
DrugC05489

CYP11B1 CYP11B2

6.92e-054782CID000440708
Diseaseadrenal cortical adenoma (is_marker_for)

CYP11B1 CYP11B2

6.90e-062782DOID:0050891 (is_marker_for)
DiseaseGlucocorticoid-remediable aldosteronism

CYP11B1 CYP11B2

6.90e-062782C1260386
Diseasecongenital adrenal hyperplasia (implicated_via_orthology)

CYP11B1 CYP11B2

2.07e-053782DOID:0050811 (implicated_via_orthology)
DiseaseAlbuminuria

NCK1 LEPR NCK2

3.46e-0524783C0001925
Diseaseapolipoprotein L1 measurement

HP CYP11B1 CYP11B2

3.92e-0525783EFO_0021854
Diseasepre-eclampsia (is_implicated_in)

HP CYP11B2 ITGAM

3.92e-0525783DOID:10591 (is_implicated_in)
Diseaseprimary hyperaldosteronism (is_implicated_in)

CYP11B1 CYP11B2

6.86e-055782DOID:446 (is_implicated_in)
DiseaseConn Syndrome

CYP11B1 CYP11B2

1.03e-046782C1384514
DiseaseHyperaldosteronism

CYP11B1 CYP11B2

1.03e-046782C0020428
DiseaseMalignant neoplasm of breast

NF1 HP SRGAP3 NUP98 MROH7 KDR DHX32 CTNNB1 FASTKD3 LEPR INPP4B

1.18e-0410747811C0006142
Diseasechronic obstructive pulmonary disease (is_marker_for)

HP KDR MUC5AC LEPR

1.30e-0497784DOID:3083 (is_marker_for)
Diseasetriglyceride measurement, C-reactive protein measurement

HPN ZNF335 LEPR

1.40e-0438783EFO_0004458, EFO_0004530
Diseaseprotocadherin alpha-7 measurement

CYP11B1 CYP11B2

1.44e-047782EFO_0801973
Diseaseprotein FAM163B measurement

CYP11B1 CYP11B2

2.45e-049782EFO_0802936
Diseasesystemic lupus erythematosus

LINGO1 SRGAP3 RALGPS2 SRGAP2 STEAP1B SLC25A19 ITGAM SEZ6L2 NCK2

2.57e-04799789MONDO_0007915
Diseasehypertension (is_implicated_in)

HP CYP11B2 KDR LEPR

3.04e-04121784DOID:10763 (is_implicated_in)
Diseaseandrostenedione measurement

CYP11B1 CYP11B2

3.06e-0410782EFO_0007972
DiseaseMachado-Joseph disease, age at onset

ATP11A LRRC28

3.74e-0411782EFO_0004847, MONDO_0007182
Disease3-hydroxyanthranilate 3,4-dioxygenase measurement

CYP11B1 CYP11B2

3.74e-0411782EFO_0021862
Diseasecell growth regulator with EF hand domain protein 1 measurement

CYP11B1 CYP11B2

3.74e-0411782EFO_0801461
Diseasebitter alcoholic beverage consumption measurement

NF1 SEZ6L2 INPP4B COPS7A

4.35e-04133784EFO_0010092
DiseaseColorectal Carcinoma

EPHB6 TNNI3K NF1 ABCA12 KDR CTNNB1 SPAG17 PPOX

5.34e-04702788C0009402
Diseaseschizophrenia (implicated_via_orthology)

MAN2A2 SRGAP3 GRIN1

7.87e-0468783DOID:5419 (implicated_via_orthology)
DiseaseHemangiosarcoma

KDR CTNNB1

1.03e-0318782C0018923
DiseaseIntellectual Disability

NF1 SRGAP3 ZNF335 CHD8 ACTL6B GRIN1

1.20e-03447786C3714756
Diseasehepatocellular carcinoma (is_marker_for)

HP ARID2 TET1 KDR CTNNB1

1.23e-03301785DOID:684 (is_marker_for)
Diseasehepatocellular carcinoma (is_implicated_in)

ARID2 KDR CTNNB1 LEPR

1.37e-03181784DOID:684 (is_implicated_in)
Diseasegastric ulcer (biomarker_via_orthology)

IDUA MUC5AC

1.40e-0321782DOID:10808 (biomarker_via_orthology)
Diseaseserum iron measurement

SRGAP3 SRGAP2 LEPR

1.55e-0386783EFO_0006332
DiseaseDyslipidemias

HP LEPR

1.83e-0324782C0242339
DiseaseDyslipoproteinemias

HP LEPR

1.83e-0324782C0598784
DiseaseEndogenous Hyperinsulinism

ITGAM LEPR

2.15e-0326782C1257963
DiseaseExogenous Hyperinsulinism

ITGAM LEPR

2.15e-0326782C1257964
DiseaseCompensatory Hyperinsulinemia

ITGAM LEPR

2.15e-0326782C1257965
DiseaseSchizophrenia

HP SRGAP3 TET1 KDR CGNL1 CTNNB1 ITGAM PCDH17

2.30e-03883788C0036341
DiseaseNephrotic Syndrome

NCK1 NCK2

2.32e-0327782C0027726
DiseaseHyperinsulinism

ITGAM LEPR

2.49e-0328782C0020459

Protein segments in the cluster

PeptideGeneStartEntry
QEVYNVGIHGPFLVI

CHD8

851

Q9HCK8
IHQVLEAPGVYVFGE

COPS7A

31

Q9UBW8
PVVITLQHIGGNQNY

ADGRG4

2666

Q8IZF6
LEYHVPVTAGGVANI

ABCA12

2521

Q86UK0
AIPVHDGYVLQQGIV

ACTL6B

176

O94805
GQTYAPAIHQIVLAN

ARID2

936

Q68CP9
LCGYPQLVTQVHVLG

CAPN5

511

O15484
ENVPLGYPVVHIQAV

CELSR1

576

Q9NYQ6
VNIGHEVGYVIPFEN

DHX32

136

Q7L7V1
IPEGVTVLYLHNNQI

FLRT2

61

O43155
YVLGQLQHEAAVPQL

DOHH

211

Q9BU89
GRVPTQQEAYQVHVG

CHDH

411

Q8NE62
IQVHYHIGLNLPGCV

MROH7

871

Q68CQ1
VHENNIPGEYLGSVL

PCDH17

481

O14917
GVYPPIQVHVTLGNE

PDK1

296

Q15118
AQNAVRLHYGLPVVV

CTNNB1

481

P35222
LIVPNLGVAVIHDYA

NUP98

1236

P52948
VVLHPNYSQVDIGLI

HP

236

P00738
LNTGQVLHVVQALYP

NCK1

186

P16333
GQGSRVLHVVQTLYP

NCK2

191

O43639
GQLLHVYPVLFNVGI

INPP4B

736

O15327
ARGIDIHGVPYVINV

DDX1

576

Q92499
IIGYVGEHGETVNIP

PDE11A

286

Q9HCR9
GLIIIQHGPYLQITH

PDZD9

41

Q8IXQ8
HQSDAGLYVIVPVII

LEPR

836

P48357
IQLVGGQLAVVEPYA

LINGO1

316

Q96FE5
VLVQQIVPVYGHFRV

MUC5AC

4946

P98088
SPHGLQLGVQAVVYH

HPN

226

P05981
VQNLVLGAPRYQHTG

ITGAD

416

Q13349
IVYHLARQGNGPVLV

UPF1

516

Q92900
LQARAYVGPHVLAVV

ATP13A2

381

Q9NQ11
PGHVILEQYQANVGA

HEATR5A

1306

Q86XA9
AGVALLNDHIYVVGG

KLHL12

466

Q53G59
QHIYQPLNLTIGVTV

GBGT1

101

Q8N5D6
GVSIRVQGIDGHPYI

CGNL1

41

Q0VF96
VQGIDGHPYIVLNNT

CGNL1

46

Q0VF96
RPVVVPNIQAGHSYV

FAT3

4136

Q8TDW7
GHTNIVEYLIQEQPG

FEM1A

226

Q9BSK4
VLQNYHIPAGTLVRV

CYP11B1

391

P15538
LHQYDGSIVVIQNPA

CADM4

46

Q8NFZ8
QLNLAYVGAVPHRGI

IDUA

71

P35475
IHQAVRLYNLPGVEG

MAN2A2

851

P49641
QIQVGLVQYGESPVH

ITGA10

201

O75578
VLQNYHIPAGTLVQV

CYP11B2

391

P19099
YAQPLVGGIVGTLHQ

DCBLD2

621

Q96PD2
VIYVLSTPAHIQIGD

DHRS11

236

Q6UWP2
YVATVHVLPEVGGIG

SLC39A9

256

Q9NUM3
SHVQPGQYVLVAGVP

IHH

296

Q14623
PHFGDIQEGIYVAIQ

KIF2B

21

Q8N4N8
VHLYPGAVTIQGVLR

RALGPS2

451

Q86X27
GHQIPGYIHILVANL

OR52J3

266

Q8NH60
AVVITGVQPEHIQYL

SMCHD1

321

A6NHR9
NGIDGLVPHQYIVVQ

SRGAP1

786

Q7Z6B7
RIIVHPNYVTAGLGA

PRSS29P

146

A6NIE9
TQQIVYHGLVPQLGE

SYNM

1321

O15061
YLHSNNIVVVPEAIG

LRRC28

71

Q86X40
QEAAPGAVYQVLLVG

PLEKHG4

271

Q58EX7
LLGYQVVQIPYHEIG

FASTKD3

621

Q14CZ7
RAHVPYILEVQAVNG

EPHB6

451

O15197
YLPVAGVLEHLNAIV

SLITRK3

541

O94933
IHVYPGYGIEIQVQT

SEZ6L2

206

Q6UXD5
VQSLVLGAPRYQHIG

ITGAM

416

P11215
HYIIVVGFNNPQLLA

SPAG17

221

Q6Q759
YLPGVIAAIVQVHNG

STEAP1B

111

Q6NZ63
VSYGLAVQGAIQILP

TET1

456

Q8NFU7
IEGHVYVPHVICNGQ

ATP11A

431

P98196
VVNLQYQGAHLPVQG

PPOX

316

P50336
HNGVDGLIPHQYIVV

SRGAP3

786

O43295
NGIDGLIPHQYIVVQ

SRGAP2

771

O75044
NLLNPIHGIVQSVVY

NF1

2676

P21359
PVIIGVVQGINYILG

RNF121

311

Q9H920
LVYHVVGVDVGFENP

SF3B3

166

Q15393
LPNVVVNGVLQGLYS

SNX22

156

Q96L94
VSLVVHYNTGGIPRI

USP37

36

Q86T82
HVVSLVVYVPPQIGE

KDR

411

P35968
PVQVVTHGLLGIYQE

THOP1

361

P52888
DIQQVGYGGLTALHI

TNNI3K

126

Q59H18
DGVQHLLPQEYVVVP

ZNF335

1231

Q9H4Z2
YVVVPEGHHIQVQEG

ZNF335

1241

Q9H4Z2
GHVPAQILSIGYGAV

SLC25A19

81

Q9HC21
LVQVGIYNGTHVIPN

GRIN1

361

Q05586