| Category | Name | IntersectionWithQuery | PValue | GenesInTerm | GenesInQuery | GenesInTermInQuery | ID |
|---|---|---|---|---|---|---|---|
| GeneOntologyMolecularFunction | transition metal ion binding | 9.18e-05 | 1189 | 26 | 8 | GO:0046914 | |
| GeneOntologyMolecularFunction | zinc ion binding | 1.07e-04 | 891 | 26 | 7 | GO:0008270 | |
| GeneOntologyBiologicalProcess | negative regulation of TORC1 signaling | 3.77e-05 | 52 | 26 | 3 | GO:1904262 | |
| GeneOntologyBiologicalProcess | positive regulation of TORC1 signaling | 4.72e-05 | 56 | 26 | 3 | GO:1904263 | |
| GeneOntologyBiologicalProcess | cellular response to amino acid starvation | 4.72e-05 | 56 | 26 | 3 | GO:0034198 | |
| GeneOntologyBiologicalProcess | maintenance of postsynaptic density structure | 5.47e-05 | 9 | 26 | 2 | GO:0099562 | |
| GeneOntologyBiologicalProcess | response to amino acid starvation | 6.10e-05 | 61 | 26 | 3 | GO:1990928 | |
| GeneOntologyBiologicalProcess | negative regulation of TOR signaling | 1.09e-04 | 74 | 26 | 3 | GO:0032007 | |
| GeneOntologyBiologicalProcess | positive regulation of TOR signaling | 1.27e-04 | 78 | 26 | 3 | GO:0032008 | |
| GeneOntologyBiologicalProcess | maintenance of postsynaptic specialization structure | 2.05e-04 | 17 | 26 | 2 | GO:0098880 | |
| GeneOntologyBiologicalProcess | regulation of myoblast differentiation | 2.07e-04 | 92 | 26 | 3 | GO:0045661 | |
| GeneOntologyBiologicalProcess | regulation of TORC1 signaling | 2.81e-04 | 102 | 26 | 3 | GO:1903432 | |
| GeneOntologyBiologicalProcess | regulation of postsynaptic density assembly | 3.16e-04 | 21 | 26 | 2 | GO:0099151 | |
| GeneOntologyBiologicalProcess | TORC1 signaling | 3.42e-04 | 109 | 26 | 3 | GO:0038202 | |
| GeneOntologyBiologicalProcess | regulation of postsynaptic specialization assembly | 4.87e-04 | 26 | 26 | 2 | GO:0099150 | |
| GeneOntologyBiologicalProcess | regulation of excitatory synapse assembly | 4.87e-04 | 26 | 26 | 2 | GO:1904889 | |
| GeneOntologyBiologicalProcess | regulation of postsynaptic density organization | 5.26e-04 | 27 | 26 | 2 | GO:1905874 | |
| GeneOntologyBiologicalProcess | embryonic brain development | 6.07e-04 | 29 | 26 | 2 | GO:1990403 | |
| GeneOntologyBiologicalProcess | myoblast differentiation | 6.52e-04 | 136 | 26 | 3 | GO:0045445 | |
| GeneOntologyBiologicalProcess | postsynaptic density assembly | 8.36e-04 | 34 | 26 | 2 | GO:0097107 | |
| GeneOntologyBiologicalProcess | negative regulation of myoblast differentiation | 8.36e-04 | 34 | 26 | 2 | GO:0045662 | |
| GeneOntologyBiologicalProcess | regulation of TOR signaling | 1.01e-03 | 158 | 26 | 3 | GO:0032006 | |
| GeneOntologyBiologicalProcess | maintenance of synapse structure | 1.16e-03 | 40 | 26 | 2 | GO:0099558 | |
| GeneOntologyBiologicalProcess | striated muscle cell differentiation | 1.37e-03 | 391 | 26 | 4 | GO:0051146 | |
| GeneOntologyBiologicalProcess | postsynaptic specialization assembly | 1.40e-03 | 44 | 26 | 2 | GO:0098698 | |
| GeneOntologyBiologicalProcess | TOR signaling | 1.49e-03 | 181 | 26 | 3 | GO:0031929 | |
| GeneOntologyBiologicalProcess | excitatory synapse assembly | 1.53e-03 | 46 | 26 | 2 | GO:1904861 | |
| GeneOntologyBiologicalProcess | cellular response to starvation | 1.59e-03 | 185 | 26 | 3 | GO:0009267 | |
| GeneOntologyBiologicalProcess | regulation of myotube differentiation | 2.18e-03 | 55 | 26 | 2 | GO:0010830 | |
| GeneOntologyBiologicalProcess | Wnt signaling pathway, planar cell polarity pathway | 2.18e-03 | 55 | 26 | 2 | GO:0060071 | |
| GeneOntologyBiologicalProcess | response to electrical stimulus | 2.26e-03 | 56 | 26 | 2 | GO:0051602 | |
| GeneOntologyBiologicalProcess | postsynaptic density organization | 2.42e-03 | 58 | 26 | 2 | GO:0097106 | |
| GeneOntologyBiologicalProcess | response to starvation | 2.91e-03 | 229 | 26 | 3 | GO:0042594 | |
| GeneOntologyBiologicalProcess | cell junction maintenance | 3.03e-03 | 65 | 26 | 2 | GO:0034331 | |
| GeneOntologyCellularComponent | GATOR2 complex | 3.73e-07 | 12 | 26 | 3 | GO:0061700 | |
| GeneOntologyCellularComponent | Seh1-associated complex | 9.46e-07 | 16 | 26 | 3 | GO:0035859 | |
| MousePheno | abnormal skeletal muscle satellite cell proliferation | 5.99e-05 | 8 | 21 | 2 | MP:0009410 | |
| Domain | LIM3_prickle | 2.39e-09 | 3 | 26 | 3 | IPR033727 | |
| Domain | LIM2_prickle | 2.39e-09 | 3 | 26 | 3 | IPR033726 | |
| Domain | PET_prickle | 2.39e-09 | 3 | 26 | 3 | IPR033723 | |
| Domain | PET | 4.78e-08 | 6 | 26 | 3 | PF06297 | |
| Domain | PET | 4.78e-08 | 6 | 26 | 3 | PS51303 | |
| Domain | PET_domain | 4.78e-08 | 6 | 26 | 3 | IPR010442 | |
| Domain | LIM1_prickle | 1.86e-06 | 2 | 26 | 2 | IPR033725 | |
| Domain | LIM | 1.18e-04 | 69 | 26 | 3 | PF00412 | |
| Domain | - | 1.23e-04 | 70 | 26 | 3 | 2.10.110.10 | |
| Domain | LIM_DOMAIN_2 | 1.29e-04 | 71 | 26 | 3 | PS50023 | |
| Domain | Znf_LIM | 1.29e-04 | 71 | 26 | 3 | IPR001781 | |
| Domain | LIM_DOMAIN_1 | 1.29e-04 | 71 | 26 | 3 | PS00478 | |
| Domain | LIM | 1.29e-04 | 71 | 26 | 3 | SM00132 | |
| Domain | WD40 | 4.83e-04 | 268 | 26 | 4 | SM00320 | |
| Domain | WD40_repeat | 5.11e-04 | 272 | 26 | 4 | IPR001680 | |
| Domain | WD_REPEATS_1 | 5.55e-04 | 278 | 26 | 4 | PS00678 | |
| Domain | WD_REPEATS_2 | 5.62e-04 | 279 | 26 | 4 | PS50082 | |
| Domain | WD_REPEATS_REGION | 5.62e-04 | 279 | 26 | 4 | PS50294 | |
| Domain | WD40_repeat_dom | 7.11e-04 | 297 | 26 | 4 | IPR017986 | |
| Domain | - | 1.09e-03 | 333 | 26 | 4 | 2.130.10.10 | |
| Domain | WD40/YVTN_repeat-like_dom | 1.11e-03 | 335 | 26 | 4 | IPR015943 | |
| Domain | WD40_repeat_CS | 1.49e-03 | 164 | 26 | 3 | IPR019775 | |
| Domain | WD40 | 5.41e-03 | 259 | 26 | 3 | PF00400 | |
| Pathway | REACTOME_AMINO_ACIDS_REGULATE_MTORC1 | 6.11e-05 | 55 | 20 | 3 | M29825 | |
| Pathway | REACTOME_AMINO_ACIDS_REGULATE_MTORC1 | 6.45e-05 | 56 | 20 | 3 | MM15667 | |
| Pubmed | The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway. | 1.30e-08 | 7 | 26 | 3 | 26972053 | |
| Pubmed | 6.09e-08 | 11 | 26 | 3 | 23723238 | ||
| Pubmed | 8.12e-08 | 12 | 26 | 3 | 25263562 | ||
| Pubmed | 1.06e-07 | 13 | 26 | 3 | 35831510 | ||
| Pubmed | Ring domains are essential for GATOR2-dependent mTORC1 activation. | 1.68e-07 | 15 | 26 | 3 | 36528027 | |
| Pubmed | 2.06e-07 | 16 | 26 | 3 | 28199315 | ||
| Pubmed | KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1. | 4.19e-07 | 20 | 26 | 3 | 28199306 | |
| Pubmed | Mouse Prickle1 and Prickle2 are expressed in postmitotic neurons and promote neurite outgrowth. | 5.37e-07 | 2 | 26 | 2 | 17868671 | |
| Pubmed | Role of Prickle1 and Prickle2 in neurite outgrowth in murine neuroblastoma cells. | 5.37e-07 | 2 | 26 | 2 | 22218901 | |
| Pubmed | 5.37e-07 | 2 | 26 | 2 | 34613779 | ||
| Pubmed | 5.37e-07 | 2 | 26 | 2 | 12525887 | ||
| Pubmed | Mutations in prickle orthologs cause seizures in flies, mice, and humans. | 5.37e-07 | 2 | 26 | 2 | 21276947 | |
| Pubmed | Prickle promotes neurite outgrowth via the Dishevelled dependent pathway in C1300 cells. | 1.61e-06 | 3 | 26 | 2 | 19788910 | |
| Pubmed | 1.61e-06 | 3 | 26 | 2 | 18976727 | ||
| Pubmed | Mink1 regulates β-catenin-independent Wnt signaling via Prickle phosphorylation. | 1.61e-06 | 3 | 26 | 2 | 22037766 | |
| Pubmed | Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway. | 1.61e-06 | 3 | 26 | 2 | 26586190 | |
| Pubmed | 3.22e-06 | 4 | 26 | 2 | 35420656 | ||
| Pubmed | Towards complete sets of farnesylated and geranylgeranylated proteins. | 3.22e-06 | 4 | 26 | 2 | 17411337 | |
| Pubmed | 3.22e-06 | 4 | 26 | 2 | 36176272 | ||
| Pubmed | Myf5 haploinsufficiency reveals distinct cell fate potentials for adult skeletal muscle stem cells. | 3.22e-06 | 4 | 26 | 2 | 22366456 | |
| Pubmed | Seizures are regulated by ubiquitin-specific peptidase 9 X-linked (USP9X), a de-ubiquitinase. | 3.22e-06 | 4 | 26 | 2 | 25763846 | |
| Pubmed | 5.37e-06 | 5 | 26 | 2 | 27378169 | ||
| Pubmed | 5.37e-06 | 5 | 26 | 2 | 26449471 | ||
| Pubmed | 5.88e-06 | 47 | 26 | 3 | 33141892 | ||
| Pubmed | The GATOR2-mTORC2 axis mediates Sestrin2-induced AKT Ser/Thr kinase activation. | 1.13e-05 | 7 | 26 | 2 | 31915252 | |
| Pubmed | Early embryonic expression patterns of the mouse Flamingo and Prickle orthologues. | 1.13e-05 | 7 | 26 | 2 | 17937400 | |
| Pubmed | 1.13e-05 | 7 | 26 | 2 | 17376975 | ||
| Pubmed | Expression of planar cell polarity genes during development of the mouse CNS. | 1.93e-05 | 9 | 26 | 2 | 16487141 | |
| Pubmed | E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression. | 1.93e-05 | 9 | 26 | 2 | 35114100 | |
| Pubmed | The histone code reader Spin1 controls skeletal muscle development. | 2.94e-05 | 11 | 26 | 2 | 29168801 | |
| Pubmed | Mouse prickle1, the homolog of a PCP gene, is essential for epiblast apical-basal polarity. | 3.53e-05 | 12 | 26 | 2 | 19706528 | |
| Pubmed | Microtubules enable the planar cell polarity of airway cilia. | 3.53e-05 | 12 | 26 | 2 | 23122850 | |
| Pubmed | 7.26e-05 | 17 | 26 | 2 | 21316586 | ||
| Pubmed | 7.26e-05 | 17 | 26 | 2 | 28292423 | ||
| Pubmed | VANGL2 regulates luminal epithelial organization and cell turnover in the mammary gland. | 8.16e-05 | 18 | 26 | 2 | 31068622 | |
| Pubmed | 1.47e-04 | 24 | 26 | 2 | 22333836 | ||
| Pubmed | Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2. | 1.52e-04 | 139 | 26 | 3 | 25476789 | |
| Pubmed | 2.01e-04 | 28 | 26 | 2 | 31719045 | ||
| Pubmed | Planar cell polarity controls pancreatic beta cell differentiation and glucose homeostasis. | 2.63e-04 | 32 | 26 | 2 | 23177622 | |
| Pubmed | The endolysosomal adaptor PLEKHM1 is a direct target for both mTOR and MAPK pathways. | 2.80e-04 | 33 | 26 | 2 | 33452816 | |
| Pubmed | [IMAGE: molecular integration of the analysis of the human genome and its expression]. | 3.15e-04 | 35 | 26 | 2 | 7757816 | |
| Pubmed | 3.33e-04 | 36 | 26 | 2 | 33230114 | ||
| Pubmed | 4.33e-04 | 41 | 26 | 2 | 22147266 | ||
| Pubmed | 4.66e-04 | 493 | 26 | 4 | 15368895 | ||
| Pubmed | 5.02e-04 | 209 | 26 | 3 | 26389662 | ||
| Interaction | SESN3 interactions | 2.76e-07 | 11 | 25 | 3 | int:SESN3 | |
| Interaction | CASTOR1 interactions | 7.60e-07 | 15 | 25 | 3 | int:CASTOR1 | |
| Interaction | CASTOR2 interactions | 9.34e-07 | 16 | 25 | 3 | int:CASTOR2 | |
| Interaction | SESN2 interactions | 1.50e-05 | 39 | 25 | 3 | int:SESN2 | |
| Interaction | SZT2 interactions | 1.74e-05 | 41 | 25 | 3 | int:SZT2 | |
| Interaction | WDR24 interactions | 2.01e-05 | 43 | 25 | 3 | int:WDR24 | |
| Interaction | KPTN interactions | 5.51e-05 | 60 | 25 | 3 | int:KPTN | |
| Interaction | SESN1 interactions | 8.07e-05 | 11 | 25 | 2 | int:SESN1 | |
| Interaction | DEPDC5 interactions | 8.37e-05 | 69 | 25 | 3 | int:DEPDC5 | |
| Interaction | PAEP interactions | 8.37e-05 | 69 | 25 | 3 | int:PAEP | |
| Interaction | KICS2 interactions | 1.33e-04 | 14 | 25 | 2 | int:KICS2 | |
| Interaction | MIOS interactions | 1.45e-04 | 83 | 25 | 3 | int:MIOS | |
| Interaction | RAE1 interactions | 1.91e-04 | 236 | 25 | 4 | int:RAE1 | |
| Interaction | PDE5A interactions | 2.77e-04 | 20 | 25 | 2 | int:PDE5A | |
| Interaction | NPRL3 interactions | 2.83e-04 | 104 | 25 | 3 | int:NPRL3 | |
| Interaction | WDR59 interactions | 3.25e-04 | 109 | 25 | 3 | int:WDR59 | |
| Interaction | LPXN interactions | 3.80e-04 | 115 | 25 | 3 | int:LPXN | |
| Interaction | NPRL2 interactions | 4.41e-04 | 121 | 25 | 3 | int:NPRL2 | |
| Interaction | ITFG2 interactions | 6.29e-04 | 30 | 25 | 2 | int:ITFG2 | |
| GeneFamily | Prickle planar cell polarity proteins|LIM domain containing | 2.76e-09 | 4 | 17 | 3 | 1184 | |
| GeneFamily | LIM domain containing | 2.17e-05 | 59 | 17 | 3 | 1218 | |
| GeneFamily | WD repeat domain containing | 1.76e-03 | 262 | 17 | 3 | 362 | |
| ToppCell | renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group | 3.94e-06 | 186 | 26 | 4 | f28d72b47624b69a580b4429e2be560a26898591 | |
| Disease | epilepsy (implicated_via_orthology) | 3.48e-04 | 163 | 25 | 3 | DOID:1826 (implicated_via_orthology) | |
| Disease | gestational age | 6.07e-03 | 138 | 25 | 2 | EFO_0005112 | |
| Disease | Malignant neoplasm of liver | 6.42e-03 | 142 | 25 | 2 | C0345904 | |
| Disease | Liver neoplasms | 6.42e-03 | 142 | 25 | 2 | C0023903 |
| Peptide | Gene | Start | Entry |
|---|---|---|---|
| CSHGDGHWVHAQCMD | 446 | P55895 | |
| THDGARVAMHCLWHG | 361 | Q15397 | |
| MHRWPVCHVAHHGGS | 136 | Q5JU00 | |
| VCHVAHHGGSWKRMF | 141 | Q5JU00 | |
| RAPTGHHQAGHCLMW | 56 | P13349 | |
| SDWCGDHGRNRCHMS | 81 | Q96KX0 | |
| CHMHSPLIHHIGWSR | 331 | Q05BQ5 | |
| RLVHWCHGAPGVIHM | 316 | Q9NS86 | |
| DECTEAEGRHWHMKH | 201 | Q96MT3 | |
| AEGRHWHMKHFCCLE | 206 | Q96MT3 | |
| ECTEAEGRHWHMKHF | 206 | Q7Z3G6 | |
| PECTEAEGRHWHMDH | 261 | O43900 | |
| AEGRHWHMDHFCCFE | 266 | O43900 | |
| TAMHWACRGGHLEVV | 216 | Q9GZV1 | |
| WTELCHRAMFHGGES | 291 | Q8NDY3 | |
| MHDGRWHHLALELRG | 151 | Q8IZC6 | |
| RCVQMLEWFDHHGHV | 221 | Q9HAZ1 | |
| WRHMFHCTGTEQHMG | 646 | Q86VB7 | |
| GGCHGFSHKFMHWQE | 281 | Q9Y6C5 | |
| TWLMHCHVTDHVHAG | 1041 | Q9BQS7 | |
| DHHMGISHVLRGSEW | 236 | Q5JPH6 | |
| IDWHHEGKQFMCSHS | 256 | Q9Y2K9 | |
| WCHNCRHGGHAGHML | 826 | Q9NXC5 | |
| RHGGHAGHMLSWFRD | 831 | Q9NXC5 | |
| MSLHHCWVLNAGGHF | 426 | Q16222 | |
| CGHGGHTSHMMEWFR | 941 | Q6PJI9 | |
| FAEWRHAHGMRCLGI | 426 | Q12874 | |
| WCQGCSHGGHLQHIM | 756 | Q96S15 | |
| CVHFAHHMFGLSWGA | 116 | Q9Y493 | |
| GVEHSQMEHWLCHRK | 366 | Q9ULV0 |