Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessphosphatidylinositol-mediated signaling

PI4KB PLCB1

7.09e-0524112GO:0048015
GeneOntologyBiologicalProcesspositive regulation of myoblast differentiation

PLCB1 SMYD1

3.64e-0454112GO:0045663
PathwayWP_PHOSPHATIDYL_INOSITOL_PHOSPHATE_PATHWAY

PI4KB PLCB1

2.16e-044672M48317
PathwayKEGG_INOSITOL_PHOSPHATE_METABOLISM

PI4KB PLCB1

2.99e-045472M3896
PathwayKEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM

PI4KB PLCB1

5.92e-047672M9052
PathwayREACTOME_NEUROTRANSMITTER_RECEPTORS_AND_POSTSYNAPTIC_SIGNAL_TRANSMISSION

PLCB1 HTR3C

4.21e-0320572M752
PathwayREACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES

PLCB1 HTR3C

7.20e-0327072M15514
PathwayREACTOME_NEURONAL_SYSTEM

PLCB1 HTR3C

1.62e-0241172M735
Pubmed

Variability in the common genetic architecture of social-communication spectrum phenotypes during childhood and adolescence.

TTC21A PLCB1

1.55e-051911224564958
Pubmed

Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease.

PI4KB DXO

2.70e-047811219204726
ToppCellfacs-Marrow-Granulocytes-3m-Myeloid-granulocyte_monocyte_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TTC21A OSCP1 MAN1C1

1.10e-0518511353854a9ec87c24c360541c83d86d8fafb303ad58
ToppCellfacs-Marrow-Granulocytes-3m-Myeloid-granulocyte_monocyte_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TTC21A OSCP1 MAN1C1

1.10e-05185113a61fc7a3700a1efcf640bef7680c0443ee148a46
ToppCellE18.5-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Deuterosomal-Deuterosomal_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TTC21A OSCP1 FAM216A

1.21e-05191113e8d56e9f43943e9cc4dce83f2c234f19c2dd487d
ToppCellE16.5-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TTC21A OSCP1 FAM216A

1.21e-051911131e21de183a9c09cfb6aad3f9b948087fb6bad061
ToppCellE16.5-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Deuterosomal-Deuterosomal_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TTC21A OSCP1 FAM216A

1.21e-051911138688708c9183ebcb200596501dc30cc12073f151
ToppCellE18.5-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Deuterosomal|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TTC21A OSCP1 FAM216A

1.21e-0519111352e8d7dfaf1ebb6df8bf3a1f4546af59faa67657
ToppCellE16.5-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Deuterosomal|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TTC21A OSCP1 FAM216A

1.23e-05192113a50a6279371b3be682e334082637b7ab76b9a6e5
ToppCellE16.5-Epithelial-Epithelial_Airway|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TTC21A OSCP1 FAM216A

1.23e-05192113bb7eb51bc079acacde42d8e55ba06d03eba2ea28
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-NP-L5_NP_VISp_Trhr_Cpne7|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

TTC21A SMYD1

1.23e-0468112cdb805182f7169fbc3bec31adec3a4e088281757
ToppCellInt-URO-Lymphocyte-T_NK-CD4_CTL|Int-URO / Disease, Lineage and Cell Type

PLCB1 OSCP1

6.19e-04153112fdc7dfa8f4db90bfdc7180bf178cf6d2dd064d97
ToppCellsevere_influenza-CD8+_T_naive|World / disease group, cell group and cell class (v2)

MAN1C1 FAM216A

6.77e-04160112a1181ef36b453eba53b04d836aa9f65a71354cdb
ToppCell5'-Adult-Appendix-Epithelial-Tuft-related|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SMYD1 HTR3C

6.94e-04162112ded08da888d8c481f0f96d1e0bfd03d617966910
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-Mes-like-AT1_Progenitor|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TTC21A FAM216A

7.02e-04163112b59d9b4f7c9f4e5e2c7783a49a96729dae3a81e5
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-Mes-like|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TTC21A FAM216A

7.02e-04163112360cd65decda24853124f33a174f5224d7f3ce23
ToppCelldroplet-Spleen-nan-18m-Myeloid-granulocyte|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TTC21A OSCP1

7.02e-04163112bc37c5d9f48b16096d5313657563f3ec84028c8c
ToppCellCiliated_cells-A-Donor_01|World / lung cells shred on cell class, cell subclass, sample id

TTC21A UGT2B17

7.02e-0416311243194c6127df1ce3d29242f719645de3c11fd7c0
ToppCellBAL-Mild-cDC_0|Mild / Compartment, Disease Groups and Clusters

MAN1C1 FAM216A

7.02e-041631127047d3ba847930f42a6d5f71e18d49f3071c6409
ToppCell356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6|356C / Donor, Lineage, Cell class and subclass (all cells)

TTC21A PLCB1

7.28e-04166112c4f7ea1cad962b1d6ad77423d15978b68a0d6f1d
ToppCelllung-Ciliated_Epithelia|lung / shred on tissue and cell subclass

TTC21A OSCP1

7.37e-0416711226cf1cfa58ee74794449a87eb19cd896e1ec8892
ToppCellfacs-Marrow-T_cells-18m-Myeloid-granulocyte_monocyte_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

OSCP1 SMYD1

7.46e-04168112260c768468dff51888f7a68e5424bb174dbaa759
ToppCellfacs-Marrow-T_cells-18m-Myeloid-granulocyte_monocyte_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

OSCP1 SMYD1

7.46e-0416811218d7719a76620d5e5698f9ffd08b4ad4cb7c13f8
ToppCell3'_v3-bone_marrow-Lymphocytic_B-ABC_aged-B_naive|bone_marrow / Manually curated celltypes from each tissue

TTC21A OSCP1

7.72e-04171112fcc31a9a69f96de10d1324a5a4fbfe4289bf4984
ToppCellfacs-Marrow-Granulocytes-24m-Myeloid-granulocyte_monocyte_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TTC21A OSCP1

7.72e-04171112dca4aa921896ec935fb7acdf25a62d8eba679602
ToppCellfacs-Marrow-Granulocytes-18m-Myeloid-granulocyte_monocyte_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TTC21A OSCP1

7.72e-04171112f15594fd4d709920733de9376a391dedc62b65de
ToppCellfacs-Marrow-Granulocytes-24m-Myeloid-granulocyte_monocyte_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TTC21A OSCP1

7.72e-04171112add2f7d34889ec654b8c71b4b1f084736111dc88
ToppCellfacs-Marrow-Granulocytes-18m-Myeloid-granulocyte_monocyte_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TTC21A OSCP1

7.72e-04171112fea6ef6bbfebea2dd0f0360c7db7a5e858f15958
ToppCell356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

TTC21A PLCB1

7.81e-04172112a9e13aa36087170dadca421ba9de588e5a1cf715
ToppCell3'-Distal_airway-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TTC21A OSCP1

7.90e-04173112c3762655caa79ac4879876f470d32578a3c93b01
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TTC21A OSCP1

8.36e-041781123b12db04006db6e94fc45649a4b3a63b92f21a61
ToppCellCiliated_cells-B-Donor_06|World / lung cells shred on cell class, cell subclass, sample id

OSCP1 UGT2B17

8.55e-04180112bdea5ec6b60fc8c7cce4d71db5da74ac8675e211
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_B-B_plasma-male|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

DXO UGT2B17

8.55e-041801128e96f8646c002768b272359af485dc0ab57e0ccd
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PLCB1 MAN1C1

8.64e-0418111222363c5835dd6cef8f895ab9362e0837d92b15b1
ToppCellTCGA-Endometrium-Primary_Tumor-Endometrial_Adenocarcinoma-Endometrioid-4|TCGA-Endometrium / Sample_Type by Project: Shred V9

TTC21A OSCP1

8.64e-0418111251d91b923920463245e95d65c6a5197e21d34d73
ToppCellcellseq-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Deuterosomal|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

OSCP1 FAM216A

8.74e-04182112deb53a4f84e4cd5c3b4180a4ac43249da9d738f7
ToppCelldroplet-Marrow-nan-21m-Lymphocytic-naive_T_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

OSCP1 FAM216A

9.12e-04186112744bf39af2fb5a7454477174d7755a6d78cd279f
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PLCB1 MAN1C1

9.22e-041871123699d5e71d779da922920aa3160895db187bf81b
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PLCB1 MAN1C1

9.22e-04187112033ba52c0c2f9978784947098fa697368ae44834
ToppCellmulticiliated|World / shred by cell class for bronchial biopsy

TTC21A OSCP1

9.32e-041881126833c1f0f265ef5448fa65033550ed7efc2f8d7b
ToppCellEpithelial-Epithelial-D_(Ciliated)|Epithelial / shred on cell class and cell subclass (v4)

TTC21A FAM216A

9.32e-041881128f30535a32968a81a304315a49c0d90a77d36948
ToppCellPND28-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TTC21A OSCP1

9.42e-04189112497be236848ebf5ad75d1f0c71e6261f5d3521da
ToppCellPND28-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TTC21A OSCP1

9.42e-04189112565063f9e3dd79164321f8a394bd12c176baf202
ToppCellPND28-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated-Ciliated_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TTC21A OSCP1

9.42e-04189112fa1ff8b7fa53f3148d9117d6e598097f03af5eb2
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PLCB1 MAN1C1

9.52e-04190112498bbe063bc75d323cb186a82cce122b511d2cff
ToppCellCOVID-19-Heart|COVID-19 / Disease (COVID-19 only), tissue and cell type

PLCB1 SMYD1

9.52e-04190112918ad5037881212008f9f69d5df5da91fd01422c
ToppCellE18.5-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TTC21A FAM216A

9.62e-04191112acd844b477a069b2dcf07b2998e1b5c87dc0eb94
ToppCell15-Trachea-Epithelial-Intermediate_ciliated|Trachea / Age, Tissue, Lineage and Cell class

TTC21A OSCP1

9.72e-041921129cbe961a800c981cdc742a47ed18e9c8eb6430bd
ToppCellNS-control-d_0-4-Epithelial-Ciliated|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

TTC21A OSCP1

1.01e-03196112d46ab80554dd3c1cc81e1938ea2acfd5e85c6d2a
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PLCB1 MAN1C1

1.01e-03196112d688350aadc622984d612ae6b2fd7c0113a4ec0f
ToppCellcontrol-Epithelial-Ciliated|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

TTC21A OSCP1

1.02e-03197112e453d085182364ca347cbcc9dc995c62c3353016
ToppCellNS-moderate-d_0-4-Epithelial-Ciliated|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

TTC21A OSCP1

1.02e-0319711271fea4aa6ce96c7693fa94792d08770622873850
ToppCellcontrol-Epithelial-Ciliated|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

TTC21A OSCP1

1.02e-03197112d4e963c1f82996371bf3d63578ee9fce8e00c5a8
ToppCellLPS_only-Epithelial_airway-airway_epithelial-Ciliated|LPS_only / Treatment groups by lineage, cell group, cell type

TTC21A OSCP1

1.03e-031981126d90b541fde357fbb40f8f7d4e8628a48b679718
ToppCell(11)_FOXN4+|World / shred by cell type by condition

OSCP1 FAM216A

1.03e-03198112516b1acdf997dd8debc3dca066519366e507b414
ToppCellSigmoid-B_cell-B_cell_IgG_Plasma|B_cell / Region, Cell class and subclass

MAN1C1 SMYD1

1.03e-03198112305d7ae9b070ac7211638a5282374c02bf13af40
ToppCellSepsis-Int-URO-Lymphocyte-T/NK-CD4+_CTL|Int-URO / Disease, condition lineage and cell class

PLCB1 OSCP1

1.03e-03198112717735d755745439f97ba1b71785c73945dfa9c5
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TTC21A OSCP1

1.05e-03200112cc906ff02fd335ff633b3b97afceb670494f910a
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TTC21A OSCP1

1.05e-03200112873def69bf55ccbfc944bc10c5afc06be019c312
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TTC21A OSCP1

1.05e-0320011279e59ab31d3d3385b1b072dc75508af9546c2e1b
Diseasehigh density lipoprotein particle size measurement

DXO UGT2B17

1.75e-03170112EFO_0008592
Diseaseresponse to paliperidone, schizophrenia symptom severity measurement

PLCB1 OSCP1

2.81e-03216112EFO_0007925, EFO_0007927
Diseasecholesteryl esters:total lipids ratio, high density lipoprotein cholesterol measurement

DXO UGT2B17

3.54e-03243112EFO_0004612, EFO_0020944
Diseasefree cholesterol measurement, high density lipoprotein cholesterol measurement

DXO UGT2B17

5.86e-03315112EFO_0004612, EFO_0008591
Diseasemitochondrial DNA measurement

TTC21A DXO

6.34e-03328112EFO_0006312
Diseaselipid measurement, high density lipoprotein cholesterol measurement

DXO UGT2B17

6.42e-03330112EFO_0004529, EFO_0004612
Diseasetestosterone measurement

PLCB1 DXO UGT2B17

1.02e-021275113EFO_0004908

Protein segments in the cluster

PeptideGeneStartEntry
KMSMGNNLYDQIMFY

HTR3C

226

Q8WXA8
LRELMYMGYKFEQYM

DXO

181

O77932
LMSGKTDMEAKNMYY

MAN1C1

401

Q9NR34
YNANYLKMLMKRQYM

FAM216A

121

Q8WUB2
MELRMFRQNEFMYYK

SMYD1

446

Q8NB12
SMDKLYDLMTMAFKY

OSCP1

96

Q8WVF1
LDGDMFNYYKMLMLQ

PI4KB

721

Q9UBF8
GALFVAYEYSRKMMM

SLC25A2

281

Q9BXI2
KAMYFMMQQNYSEAL

TTC21A

186

Q8NDW8
LAMQINMGMYEYNGK

PLCB1

631

Q9NQ66
MIFMERIKNMIYMLY

UGT2B17

206

O75795