Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionendopolyphosphatase activity

NUDT4 NUDT4B

3.15e-055362GO:0000298
GeneOntologyMolecularFunctionbis(5'-adenosyl)-hexaphosphatase activity

NUDT4 NUDT4B

3.15e-055362GO:0034431
GeneOntologyMolecularFunctiondiphosphoinositol-polyphosphate diphosphatase activity

NUDT4 NUDT4B

3.15e-055362GO:0008486
GeneOntologyMolecularFunctionbis(5'-adenosyl)-pentaphosphatase activity

NUDT4 NUDT4B

4.72e-056362GO:0034432
GeneOntologyMolecularFunctiondouble-stranded RNA binding

SLC3A2 MBNL1 STAU1

3.73e-0478363GO:0003725
GeneOntologyBiologicalProcessadenosine 5'-(hexahydrogen pentaphosphate) metabolic process

NUDT4 NUDT4B

2.95e-055362GO:1901910
GeneOntologyBiologicalProcessadenosine 5'-(hexahydrogen pentaphosphate) catabolic process

NUDT4 NUDT4B

2.95e-055362GO:1901911
GeneOntologyBiologicalProcessdiadenosine pentaphosphate catabolic process

NUDT4 NUDT4B

2.95e-055362GO:1901907
GeneOntologyBiologicalProcessdiadenosine pentaphosphate metabolic process

NUDT4 NUDT4B

2.95e-055362GO:1901906
GeneOntologyBiologicalProcessdiadenosine hexaphosphate catabolic process

NUDT4 NUDT4B

2.95e-055362GO:1901909
GeneOntologyBiologicalProcessdiadenosine hexaphosphate metabolic process

NUDT4 NUDT4B

2.95e-055362GO:1901908
GeneOntologyBiologicalProcessdiphosphoinositol polyphosphate metabolic process

NUDT4 NUDT4B

2.95e-055362GO:0071543
GeneOntologyBiologicalProcessdiadenosine polyphosphate catabolic process

NUDT4 NUDT4B

4.42e-056362GO:0015961
GeneOntologyBiologicalProcessdiadenosine polyphosphate metabolic process

NUDT4 NUDT4B

1.06e-049362GO:0015959
GeneOntologyBiologicalProcessnegative regulation of urine volume

MLLT6 NFAT5

1.61e-0411362GO:0035811
GeneOntologyBiologicalProcessregulation of microvillus organization

VIL1 HNF4A

3.07e-0415362GO:0032530
DomainPHD

MLLT6 KMT2B PYGO1

3.71e-0475353PF00628
DomainZnf_PHD-finger

MLLT6 KMT2B PYGO1

4.32e-0479353IPR019787
DomainPHD

MLLT6 KMT2B PYGO1

6.13e-0489353SM00249
DomainZnf_PHD

MLLT6 KMT2B PYGO1

6.54e-0491353IPR001965
DomainZF_PHD_2

MLLT6 KMT2B PYGO1

7.42e-0495353PS50016
DomainZF_PHD_1

MLLT6 KMT2B PYGO1

7.64e-0496353PS01359
DomainEPHD

MLLT6 KMT2B

7.70e-0422352PS51805
DomainMyb_DNA-binding

NCOR2 TERF2

1.95e-0335352PF00249
DomainMYB_LIKE

NCOR2 TERF2

2.30e-0338352PS50090
DomainZnf_FYVE_PHD

MLLT6 KMT2B PYGO1

2.60e-03147353IPR011011
DomainSANT

NCOR2 TERF2

3.95e-0350352SM00717
DomainSANT/Myb

NCOR2 TERF2

4.27e-0352352IPR001005
DomainZinc_finger_PHD-type_CS

MLLT6 PYGO1

6.59e-0365352IPR019786
Pubmed

An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase.

ARHGAP29 SLC6A9 NCOR2 SLC4A7 MBNL1

1.53e-0618038535198878
Pubmed

Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray.

PCNX1 SLC4A7 NUDT4 HNF4A GALNT4 MBNL1

2.93e-0637138615747579
Pubmed

WDR26 functions as a scaffolding protein to promote Gβγ-mediated phospholipase C β2 (PLCβ2) activation in leukocytes.

PLCB2 WDR26

3.48e-06338223625927
Pubmed

Genetic rationale for microheterogeneity of human diphosphoinositol polyphosphate phosphohydrolase type 2.

NUDT4 NUDT4B

3.48e-06338211376937
Pubmed

Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.

NCOR2 MLLT6 NUDT4 MED13L NFAT5 TERF2 TLN1 TP53BP2 STAU1

6.06e-06124738927684187
Pubmed

Developmentally regulated N-terminal variants of the nuclear receptor hepatocyte nuclear factor 4alpha mediate multiple interactions through coactivator and corepressor-histone deacetylase complexes.

NCOR2 HNF4A

6.96e-06438212205093
Pubmed

Role of a BCL9-related beta-catenin-binding protein, B9L, in tumorigenesis induced by aberrant activation of Wnt signaling.

HNF4A PYGO1

1.74e-05638215574752
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

NCOR2 MLLT6 MED13L KMT2B TLN1 SLC3A2 MBNL1 STAU1

2.09e-05110338834189442
Pubmed

Disruption of Hox9,10,11 function results in cellular level lineage infidelity in the kidney.

VIL1 HNF4A

2.43e-05738229679048
Pubmed

Genetic predictors of interindividual variability in hepatic CYP3A4 expression.

NCOR2 HNF4A

2.43e-05738219934400
Pubmed

Gastric tuft cells express DCLK1 and are expanded in hyperplasia.

VIL1 PLCB2

3.24e-05838221688022
Pubmed

A postnatal switch of CELF and MBNL proteins reprograms alternative splicing in the developing heart.

NCOR2 NFAT5 MBNL1

3.94e-056038319075228
Pubmed

Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned.

ZFHX3 WDR26

4.16e-05938221042317
Pubmed

FBP WW domains and the Abl SH3 domain bind to a specific class of proline-rich ligands.

ZFHX3 KMT2B

5.20e-05103829171351
Pubmed

Cholinergic chemosensory cells in the trachea regulate breathing.

VIL1 PLCB2

6.35e-051138221606356
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

NCOR2 ZFHX3 KMT2B WDR26 TP53BP2

8.87e-0541838534709266
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

NCOR2 MLLT6 MAP4K1 TLN1 TP53BP2

1.01e-0443038535044719
Pubmed

Sox17 regulates organ lineage segregation of ventral foregut progenitor cells.

VIL1 HNF4A

1.05e-041438219619492
Pubmed

Revisiting the role of Notch in nephron segmentation confirms a role for proximal fate selection during mouse and human nephrogenesis.

HNF4A FOXD1

1.05e-041438235451473
Pubmed

Reduced Abd-B Hox function during kidney development results in lineage infidelity.

HNF4A FOXD1

1.05e-041438229596840
Pubmed

Pbx1-dependent control of VMC differentiation kinetics underlies gross renal vascular patterning.

VIL1 FOXD1

1.21e-041538226138478
Pubmed

Skn-1a/Pou2f3 is required for the generation of Trpm5-expressing microvillous cells in the mouse main olfactory epithelium.

VIL1 PLCB2

1.21e-041538224428937
Pubmed

DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.

MED13L TERF2 WDR26 SLC3A2 MBNL1

1.29e-0445338529656893
Pubmed

Human transcription factor protein interaction networks.

NCOR2 MLLT6 ZFHX3 KMT2B HNF4A MBNL1 STAU1 PYGO1

1.29e-04142938835140242
Pubmed

A subset of mouse colonic goblet cells expresses the bitter taste receptor Tas2r131.

VIL1 PLCB2

1.56e-041738224367558
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

LPCAT4 NCOR2 ZFHX3 SIGLEC1 ATP2C1 WDR26 ELL3

1.82e-04111638731753913
Pubmed

HNF4 factors control chromatin accessibility and are redundantly required for maturation of the fetal intestine.

VIL1 HNF4A

1.96e-041938231345929
Pubmed

Defining the membrane proteome of NK cells.

LPCAT4 FKBP15 NCOR2 ATP2C1 MAP4K1 SLC3A2 STAU1

2.40e-04116838719946888
Pubmed

Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension.

SLC4A7 MED13L

2.41e-042138225249183
Pubmed

VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells.

VIL1 FKBP15 TERF2 SLC3A2

2.72e-0428838423383273
Pubmed

Retinoic acid signalling induces the differentiation of mouse fetal liver-derived hepatic progenitor cells.

NCOR2 HNF4A

2.90e-042338219737349
Pubmed

Hepatocyte nuclear factor 1β controls nephron tubular development.

VIL1 HNF4A

2.90e-042338223362349
Pubmed

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.

ARHGAP29 SLC4A7 TLN1 TP53BP2 SLC3A2

3.58e-0456538525468996
Pubmed

Identification by proximity labeling of novel lipidic and proteinaceous potential partners of the dopamine transporter.

SLC6A9 SLC3A2

4.01e-042738234709416
Pubmed

The cellular and molecular landscape of hypothalamic patterning and differentiation from embryonic to late postnatal development.

ZFHX3 FOXD1

4.32e-042838232868762
Pubmed

Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.

KMT2B MAP4K1 TP53BP2 GUCY2D

4.50e-0432938417474147
Pubmed

Assembly of the WHIP-TRIM14-PPP6C Mitochondrial Complex Promotes RIG-I-Mediated Antiviral Signaling.

NFAT5 WDR26 SLC3A2 STAU1

4.66e-0433238429053956
Pubmed

Hnf1b haploinsufficiency differentially affects developmental target genes in a new renal cysts and diabetes mouse model.

VIL1 HNF4A

7.15e-043638233737325
Pubmed

Quantitative Proteomics Links the LRRC59 Interactome to mRNA Translation on the ER Membrane.

SLC4A7 TLN1 SLC3A2 STAU1

7.35e-0437538432788342
Pubmed

Kruppel-like factor 5 controls villus formation and initiation of cytodifferentiation in the embryonic intestinal epithelium.

VIL1 HNF4A

7.56e-043738223266329
Pubmed

Human variation in alcohol response is influenced by variation in neuronal signaling genes.

ZFHX3 TERF2 GUCY2D

8.68e-0417138320201926
Pubmed

Identification of molecular compartments and genetic circuitry in the developing mammalian kidney.

HNF4A FOXD1

8.83e-044038222510988
Pubmed

Characterization of the DOT1L network: implications of diverse roles for DOT1L.

MLLT6 ELL3

9.28e-044138220431927
Pubmed

Identification and characterization of proteins interacting with SIRT1 and SIRT3: implications in the anti-aging and metabolic effects of sirtuins.

ARHGAP29 ELL3

9.28e-044138219343720
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

FKBP15 MED13L NFAT5 TLN1

9.96e-0440738412693553
Pubmed

A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.

ZFHX3 HNF4A NFAT5 MBNL1 PYGO1

9.98e-0470938522988430
Pubmed

BPA modulates the WDR5/TET2 complex to regulate ERβ expression in eutopic endometrium and drives the development of endometriosis.

VIL1 KMT2B TLN1 SLC3A2 STAU1

1.01e-0371138533022573
Pubmed

Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.

ARHGAP29 NCOR2 STAU1

1.07e-0318438332908313
CytobandEnsembl 112 genes in cytogenetic band chr16q22

ZFHX3 NFAT5 TERF2

4.74e-04183383chr16q22
Cytoband16q22.1

NFAT5 TERF2

3.78e-0311038216q22.1
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

FKBP15 SPOCD1 TP53BP2 STAU1

3.17e-04181334694
GeneFamilyPHD finger proteins

MLLT6 KMT2B PYGO1

5.84e-049033388
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_DN

ARHGAP29 NCOR2 ZFHX3 ATP2C1 SLC4A7 MED13L TP53BP2 FOXD1 MBNL1

2.21e-06856379M4500
CoexpressionBUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP

PCNX1 SLC4A7 NUDT4 MED13L KMT2B NFAT5 TP53BP2 SLC3A2

1.56e-05822378M6782
CoexpressionBUSSLINGER_GASTRIC_IMMUNE_CELLS

PCNX1 MLLT6 PLCB2 SH2D2A SLC4A7 NFAT5 WDR26 MAP4K1 TLN1 MBNL1

2.93e-0514923710M40023
CoexpressionBUSSLINGER_DUODENAL_IMMUNE_CELLS

PCNX1 MLLT6 PLCB2 SH2D2A WDR26 MAP4K1 TLN1 MBNL1

3.25e-05911378M40038
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN

ARHGAP29 SLC4A7 MED13L TP53BP2 FOXD1 MBNL1

4.45e-05466376M13522
CoexpressionAMIT_EGF_RESPONSE_480_HELA

LPCAT4 SH2D2A NUDT4 FOXD1

8.31e-05164374M8729
CoexpressionGSE35825_UNTREATED_VS_IFNG_STIM_MACROPHAGE_DN

ZFHX3 TERF2 WDR26 MBNL1

1.22e-04181374M8662
CoexpressionGSE41176_UNSTIM_VS_ANTI_IGM_STIM_TAK1_KO_BCELL_24H_DN

SLC6A9 SH2D2A ATP2C1 NFAT5

1.75e-04199374M9920
CoexpressionGSE36826_NORMAL_VS_STAPH_AUREUS_INF_IL1R_KO_SKIN_DN

PLCB2 SLC4A7 WDR26 SLC3A2

1.75e-04199374M9532
CoexpressionGSE37532_TREG_VS_TCONV_PPARG_KO_CD4_TCELL_FROM_LN_UP

ARHGAP29 NUDT4 MED13L TERF2

1.78e-04200374M8959
CoexpressionGSE22140_HEALTHY_VS_ARTHRITIC_GERMFREE_MOUSE_CD4_TCELL_DN

NCOR2 ZFHX3 TP53BP2 SLC3A2

1.78e-04200374M7646
CoexpressionGSE15330_LYMPHOID_MULTIPOTENT_VS_PRO_BCELL_UP

TERF2 WDR26 GALNT4 SLC3A2

1.78e-04200374M7011
CoexpressionGSE360_DC_VS_MAC_B_MALAYI_HIGH_DOSE_UP

NCOR2 PLCB2 SLC4A7 MBNL1

1.78e-04200374M5185
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

PCNX1 ATP2C1 MED13L NFAT5 TP53BP2 MBNL1

1.21e-08188386ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
DrugIsoniazid [54-85-3]; Up 200; 29.2uM; HL60; HG-U133A

PCNX1 ATP2C1 SLC4A7 MED13L NFAT5 MBNL1

7.02e-071963761399_UP
DrugDipyrone [5907-38-0]; Up 200; 12uM; PC3; HT_HG-U133A

SLC6A9 ZFHX3 HNF4A TLN1 GUCY2D

1.49e-051943754310_UP
DrugSulfasalazine [599-79-1]; Up 200; 10uM; HL60; HG-U133A

FKBP15 PLCB2 ATP2C1 KMT2B NFAT5

1.64e-051983751733_UP
DrugTremorine dihydrochloride [300-68-5]; Up 200; 15uM; HL60; HG-U133A

LPCAT4 PLCB2 SIGLEC1 ATP2C1 SLC4A7

1.64e-051983751579_UP
Diseaseobesity (implicated_via_orthology)

ZFHX3 PLCB2 MED13L HNF4A

1.34e-04215364DOID:9970 (implicated_via_orthology)
Diseasediastolic blood pressure, systolic blood pressure

ZFHX3 SLC4A7 NFAT5 TERF2 GUCY2D MBNL1

1.46e-04670366EFO_0006335, EFO_0006336
Diseasetestosterone measurement

VIL1 NCOR2 ZFHX3 PNMA6E SPOCD1 HNF4A MBNL1

7.68e-041275367EFO_0004908
Diseasepulse pressure measurement

ZFHX3 SLC4A7 MED13L NFAT5 TERF2 FOXD1 MBNL1

1.28e-031392367EFO_0005763
Diseasebreast cancer (is_marker_for)

NCOR2 ZFHX3 KMT2B

1.49e-03185363DOID:1612 (is_marker_for)
Diseasephosphoglycerides measurement

NCOR2 HNF4A

1.58e-0348362EFO_0022291
Diseasesusceptibility to bacterial meningitis measurement

SLC6A9 NFAT5

1.85e-0352362EFO_0008411
DiseaseMetastatic melanoma

MAP4K1 GUCY2D

1.99e-0354362C0278883
Diseasesexual dimorphism measurement

VIL1 NCOR2 ZFHX3 KMT2B SPOCD1 HNF4A

2.03e-031106366EFO_0021796
Diseasetotal blood protein measurement

ARHGAP29 NCOR2 SIGLEC1 MBNL1

2.12e-03449364EFO_0004536
DiseaseSjogren syndrome

SH2D2A NFAT5

2.45e-0360362EFO_0000699
Diseasechronic kidney disease

PLCB2 NFAT5 MBNL1

2.93e-03235363EFO_0003884
Diseasecongenital heart disease (implicated_via_orthology)

PLCB2 KMT2B

3.23e-0369362DOID:1682 (implicated_via_orthology)
Diseaseresponse to ketamine

ZFHX3 MBNL1

3.23e-0369362EFO_0009748
Diseasevital capacity

NCOR2 ZFHX3 NFAT5 WDR26 MBNL1 STAU1

3.54e-031236366EFO_0004312
DiseaseDrugs used in diabetes use measurement

ZFHX3 HNF4A NFAT5

3.69e-03255363EFO_0009924
DiseaseAmphetamine Abuse

SLC6A9 FKBP15

3.80e-0375362C0236807
DiseaseAmphetamine Addiction

SLC6A9 FKBP15

3.80e-0375362C0236804
DiseaseAmphetamine-Related Disorders

SLC6A9 FKBP15

3.80e-0375362C0236733
DiseaseCleft Palate

ARHGAP29 MED13L

4.41e-0381362C0008925
Diseaseaspartate aminotransferase measurement

ARHGAP29 NCOR2 SLC4A7 MBNL1 STAU1

4.58e-03904365EFO_0004736
Diseasephosphatidylcholine measurement

NCOR2 ZFHX3 HNF4A

4.98e-03284363EFO_0010226

Protein segments in the cluster

PeptideGeneStartEntry
SQQASSFGSAPAQLP

nan

36

Q6ZRM9
AAAPNPASLSQAGGA

MLLT6

906

P55198
DPLASNQGQSLPGSS

ELL3

166

Q9HB65
TANSQSPALLAGTNP

ANKRD13C

86

Q8N6S4
PVSSDGNLPQQAASA

TP53BP2

326

Q13625
PQPAATNGDLASRSN

ATP2C1

201

P98194
AAQAAAAAQASPSPS

FOXD1

381

Q16676
SANAFNPLNASASLP

NCOR2

2361

Q9Y618
PVTLNSAAPASNSGA

MED13L

1021

Q71F56
NASSPGNPTALANGT

LPCAT4

501

Q643R3
ANGNSTVPSLPDNNA

NUDT4B

151

A0A024RBG1
SPGPEALAALANSSQ

GUCY2D

286

Q02846
SPSEGTNLNAPNSLG

HNF4A

41

P41235
ATDAQPGNTLSPANN

PCNX1

2221

Q96RV3
DPAAAQASPAQGNAS

PNMA6E

516

A0A0J9YXQ4
NGNSTVPSLPDNNAL

NUDT4

151

Q9NZJ9
ASASSGQPQAPLNRE

FKBP15

961

Q5T1M5
PLANGSQPSQGLTAS

KMT2B

2141

Q9UMN6
FPSTASANGNLQQSP

NFAT5

916

O94916
LNSSQPSGFGPANSL

ARHGAP29

486

Q52LW3
NSPDNNPTGANLSLF

GALNT4

461

Q8N4A0
LLASGDPLPSASQNA

SLC3A2

51

P08195
APSLATNASAAAFNP

MBNL1

121

Q9NR56
PPSTLNNTSGSLLNA

nan

336

A6NNC1
NLLLPGSSNSPASAS

MAP4K1

811

Q92918
SNPDLASNFVPGNNS

PYGO1

196

Q9Y3Y4
ILASPQSAPGNLDNS

SLC4A7

376

Q9Y6M7
AASPQAPEAASNTGN

SH2D2A

41

Q9NP31
QLAPGRGSNNSSLPA

TSACC

96

Q96A04
DVFNANSNLSSGPLP

VIL1

751

P09327
NAGRPIQNSALPSAS

STAU1

46

O95793
RGSQAQPDSPSAQLA

TLN1

971

Q9Y490
APPQSAALCLGASAQ

SPOCD1

321

Q6ZMY3
SNLTNGSRPAALPSN

SLC6A9

236

P48067
QAQAPGSATTSLAAP

SIGLEC1

961

Q9BZZ2
NGALAPTSNGSPAAR

PLCB2

856

Q00722
ANGLLPSAPSAASNN

WDR26

56

Q9H7D7
SAGLNSSQEAASAPP

TERF2

416

Q15554
SNPSSAGIAPSSNLL

ZFHX3

1666

Q15911
ALAANTSAPAAGSPL

NEXN-AS1

216

Q8NBZ9