Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	copper ion transmembrane transporter activity	ATP7A ATP7B SLC31A2	1.37e-05	8	127	3	GO:0005375
GeneOntologyMolecularFunction	P-type divalent copper transporter activity	ATP7A ATP7B	4.01e-05	2	127	2	GO:0043682
GeneOntologyMolecularFunction	P-type monovalent copper transporter activity	ATP7A ATP7B	4.01e-05	2	127	2	GO:0140581
GeneOntologyMolecularFunction	triplex DNA binding	DDX12P DDX11	2.39e-04	4	127	2	GO:0045142
GeneOntologyMolecularFunction	transporter activity	NPC1 CNNM2 ATP7A ATP7B SLC31A2 NOX5 SLCO2B1 ATG2B MFSD9 RHCE RYR2 LRRC52 ITPR3 LRRC55 TMC8 SLC35E4 STRA6 ZDHHC13 ATP6V0A2	5.07e-04	1289	127	19	GO:0005215
GeneOntologyMolecularFunction	potassium channel activator activity	LRRC52 LRRC55	5.92e-04	6	127	2	GO:0099104
GeneOntologyMolecularFunction	inorganic cation transmembrane transporter activity	CNNM2 ATP7A ATP7B SLC31A2 NOX5 RHCE RYR2 LRRC52 ITPR3 LRRC55 ZDHHC13 ATP6V0A2	6.65e-04	627	127	12	GO:0022890
GeneOntologyMolecularFunction	L-leucine binding	UBR1 UBR2	8.25e-04	7	127	2	GO:0070728
GeneOntologyBiologicalProcess	copper ion import	ATP7A ATP7B SLC31A2	1.91e-05	9	128	3	GO:0015677
GeneOntologyBiologicalProcess	copper ion transmembrane transport	ATP7A ATP7B SLC31A2	1.91e-05	9	128	3	GO:0035434
MousePheno	abnormal kidney copper level	ATP7A ATP7B	4.67e-05	2	96	2	MP:0010242
MousePheno	increased kidney copper level	ATP7A ATP7B	4.67e-05	2	96	2	MP:0010243
MousePheno	increased brain copper level	ATP7A ATP7B	4.67e-05	2	96	2	MP:0011214
Domain	ARM-type_fold	USP34 RSPH14 DOCK8 USP24 RICTOR RSPRY1 RIF1 VAC14 PELP1 PIK3CD INSC	1.51e-05	339	123	11	IPR016024
Domain	ClpS	UBR1 UBR2	4.30e-05	2	123	2	PF02617
Domain	P-typ_ATPase_IB	ATP7A ATP7B	4.30e-05	2	123	2	IPR027256
Domain	ClpS_core	UBR1 UBR2	4.30e-05	2	123	2	IPR003769
Domain	HMA_Cu_ion-bd	ATP7A ATP7B	4.30e-05	2	123	2	IPR006122
Domain	Ribosomal_L7/12_C/ClpS-like	UBR1 UBR2	1.29e-04	3	123	2	IPR014719
Domain	Oat_ACAT_DAG_ARE	SOAT2 DGAT1	1.29e-04	3	123	2	IPR014371
Domain	-	UBR1 UBR2	1.29e-04	3	123	2	3.30.1390.10
Domain	Heavy-metal-associated_CS	ATP7A ATP7B	1.29e-04	3	123	2	IPR017969
Domain	VWC_out	FRAS1 FCGBP OTOG	2.50e-04	19	123	3	SM00215
Domain	HMA	ATP7A ATP7B	2.56e-04	4	123	2	PF00403
Domain	DEK_C	SSH1 SSH2	2.56e-04	4	123	2	PF08766
Domain	DEK_C	SSH1 SSH2	2.56e-04	4	123	2	IPR014876
Domain	HMA_2	ATP7A ATP7B	2.56e-04	4	123	2	PS50846
Domain	HMA_1	ATP7A ATP7B	2.56e-04	4	123	2	PS01047
Domain	ARM-like	RSPH14 DOCK8 RICTOR RSPRY1 RIF1 VAC14 PELP1 INSC	4.23e-04	270	123	8	IPR011989
Domain	Autophagy-rel_C	ATG2B VPS13B	4.25e-04	5	123	2	IPR015412
Domain	ATG_C	ATG2B VPS13B	4.25e-04	5	123	2	PF09333
Domain	RIH_assoc-dom	RYR2 ITPR3	6.34e-04	6	123	2	IPR013662
Domain	Ins145_P3_rec	RYR2 ITPR3	6.34e-04	6	123	2	PF08709
Domain	RIH_assoc	RYR2 ITPR3	6.34e-04	6	123	2	PF08454
Domain	RIH_dom	RYR2 ITPR3	6.34e-04	6	123	2	IPR000699
Domain	Ins145_P3_rcpt	RYR2 ITPR3	6.34e-04	6	123	2	IPR014821
Domain	Ryanodine_recept-rel	RYR2 ITPR3	6.34e-04	6	123	2	IPR015925
Domain	-	RYR2 ITPR3	6.34e-04	6	123	2	1.25.10.30
Domain	RYDR_ITPR	RYR2 ITPR3	6.34e-04	6	123	2	PF01365
Domain	ZnF_UBR1	UBR1 UBR2	8.84e-04	7	123	2	SM00396
Domain	ZF_UBR	UBR1 UBR2	8.84e-04	7	123	2	PS51157
Domain	HMA_dom	ATP7A ATP7B	8.84e-04	7	123	2	IPR006121
Domain	zf-UBR	UBR1 UBR2	8.84e-04	7	123	2	PF02207
Domain	Znf_UBR	UBR1 UBR2	8.84e-04	7	123	2	IPR003126
Domain	Chorein_N	ATG2B VPS13B	1.17e-03	8	123	2	PF12624
Domain	VPS13_N	ATG2B VPS13B	1.17e-03	8	123	2	IPR026854
Domain	MIR	RYR2 ITPR3	1.87e-03	10	123	2	PF02815
Domain	MIR_motif	RYR2 ITPR3	1.87e-03	10	123	2	IPR016093
Domain	MIR	RYR2 ITPR3	1.87e-03	10	123	2	PS50919
Domain	MIR	RYR2 ITPR3	1.87e-03	10	123	2	SM00472
Domain	MBOAT	SOAT2 DGAT1	2.28e-03	11	123	2	PF03062
Domain	MBOAT_fam	SOAT2 DGAT1	2.28e-03	11	123	2	IPR004299
Domain	PTB	EPS8L1 TBC1D1 RABGAP1L	2.31e-03	40	123	3	SM00462
Domain	PTB/PI_dom	EPS8L1 TBC1D1 RABGAP1L	2.48e-03	41	123	3	IPR006020
Domain	VWF_dom	FRAS1 FCGBP OTOG	2.65e-03	42	123	3	IPR001007
Domain	C8	FCGBP OTOG	2.72e-03	12	123	2	PF08742
Domain	TIL	FCGBP OTOG	2.72e-03	12	123	2	PF01826
Domain	Unchr_dom_Cys-rich	FCGBP OTOG	3.20e-03	13	123	2	IPR014853
Domain	C8	FCGBP OTOG	3.20e-03	13	123	2	SM00832
Domain	TIL_dom	FCGBP OTOG	3.72e-03	14	123	2	IPR002919
Domain	VWF_type-D	FCGBP OTOG	4.86e-03	16	123	2	IPR001846
Domain	VWFD	FCGBP OTOG	4.86e-03	16	123	2	PS51233
Domain	VWD	FCGBP OTOG	4.86e-03	16	123	2	SM00216
Domain	VWD	FCGBP OTOG	4.86e-03	16	123	2	PF00094
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	NPC1 NRM USP34 UBR2 FRAS1 TMEM161B GNPTAB EMC8 HM13 DIPK2A TGFB1 MET VAC14 EEF2 CD47 TMEM131L ROBO1 TMEM164 ZDHHC13 DGAT1 ATP6V0A2	4.14e-09	1201	130	21	35696571
Pubmed	Association between polymorphisms in CTR1, CTR2, ATP7A, and ATP7B and platinum resistance in epithelial ovarian cancer.	ATP7A ATP7B SLC31A2	5.10e-08	3	130	3	28737129
Pubmed	Defining the membrane proteome of NK cells.	NPC1 NRM XRN2 ATP7A ATP7B ABR NUP107 DOCK8 PSMD13 EMC8 HM13 ITPR3 EEF2 NOP14 PELP1 ACAP2 ZDHHC13	1.80e-06	1168	130	17	19946888
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	USP34 ATP7B NLRX1 EMC8 ADCY6 TGFB1 S1PR5 MET RIF1 ARSL TMEM168 RABGAP1L TMEM164 STRA6 ZDHHC13 ATP6V0A2	2.36e-06	1061	130	16	33845483
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	NPC1 ATP7A ATP7B ACTR10 ATG2B EMC8 ITPR3 VAC14 TMEM131L ZDHHC13 VPS13B	3.28e-06	504	130	11	34432599
Pubmed	Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.	NPC1 ATP7A SLC31A2 GNPTAB RICTOR ACTRT2 EMC8 TUBGCP5 PEX26 TGFB1 IGF2BP1 AIFM2 ARSL SSH1 COQ4 ROBO1 TMEM164	6.92e-06	1293	130	17	15342556
Pubmed	Copper efflux transporters ATP7A and ATP7B: Novel biomarkers for platinum drug resistance and targets for therapy.	ATP7A ATP7B	1.39e-05	2	130	2	29394468
Pubmed	Expression of the Menkes gene homologue in mouse tissues lack of effect of copper on the mRNA levels.	ATP7A ATP7B	1.39e-05	2	130	2	8082762
Pubmed	Bound Waters Mediate Binding of Diverse Substrates to a Ubiquitin Ligase.	UBR1 UBR2	1.39e-05	2	130	2	28392261
Pubmed	Delineation of metabolic responses of Npc1-/-nih mice lacking the cholesterol-esterifying enzyme SOAT2 to acute treatment with 2-hydroxypropyl-β-cyclodextrin.	NPC1 SOAT2	1.39e-05	2	130	2	32890578
Pubmed	TGF-β1 impairs mechanosensation of human osteoblasts via HDAC6-mediated shortening and distortion of primary cilia.	HDAC6 TGFB1	1.39e-05	2	130	2	28271209
Pubmed	Solution structures of the actuator domain of ATP7A and ATP7B, the Menkes and Wilson disease proteins.	ATP7A ATP7B	1.39e-05	2	130	2	19645496
Pubmed	Differential intracellular localisation of the Menkes and Wilson copper transporting ATPases in the third trimester human placenta.	ATP7A ATP7B	1.39e-05	2	130	2	21115196
Pubmed	Role of N-end rule ubiquitin ligases UBR1 and UBR2 in regulating the leucine-mTOR signaling pathway.	UBR1 UBR2	1.39e-05	2	130	2	20298436
Pubmed	Mechanisms of charge transfer in human copper ATPases ATP7A and ATP7B.	ATP7A ATP7B	1.39e-05	2	130	2	28164426
Pubmed	Amelotin gene expression is temporarily being upregulated at the initiation of apoptosis induced by TGFβ1 in mouse gingival epithelial cells.	TGFB1 AMTN	1.39e-05	2	130	2	27502207
Pubmed	Biochemical basis of regulation of human copper-transporting ATPases.	ATP7A ATP7B	1.39e-05	2	130	2	17562324
Pubmed	Genes regulating copper metabolism.	ATP7A ATP7B	1.39e-05	2	130	2	9823011
Pubmed	Deficiency of UBR1, a ubiquitin ligase of the N-end rule pathway, causes pancreatic dysfunction, malformations and mental retardation (Johanson-Blizzard syndrome).	UBR1 UBR2	1.39e-05	2	130	2	16311597
Pubmed	Molecular pathogenesis of Wilson and Menkes disease: correlation of mutations with molecular defects and disease phenotypes.	ATP7A ATP7B	1.39e-05	2	130	2	17717039
Pubmed	A puzzle over several decades: eye anomalies with FRAS1 and STRA6 mutations in the same family.	FRAS1 STRA6	1.39e-05	2	130	2	22283518
Pubmed	Genetic polymorphisms of copper- and platinum drug-efflux transporters ATP7A and ATP7B in Japanese cancer patients.	ATP7A ATP7B	1.39e-05	2	130	2	20045993
Pubmed	Phylogenomic analyses reveal the evolutionary origin of the inhibin alpha-subunit, a unique TGFbeta superfamily antagonist.	INHA TGFB1	1.39e-05	2	130	2	20209104
Pubmed	Regulation of the apico-basolateral trafficking polarity of the homologous copper-ATPases ATP7A and ATP7B.	ATP7A ATP7B	1.39e-05	2	130	2	38032054
Pubmed	Molecular features of copper binding proteins involved in copper homeostasis.	ATP7A ATP7B	1.39e-05	2	130	2	27896900
Pubmed	Wide long lasting perinuclear Ca2+ release events generated by an interaction between ryanodine and IP3 receptors in canine Purkinje cells.	RYR2 ITPR3	1.39e-05	2	130	2	18586264
Pubmed	Co-expression of MET and CD47 is a novel prognosticator for survival of luminal breast cancer patients.	MET CD47	1.39e-05	2	130	2	25230070
Pubmed	Localization of chi1-related helicase genes to human chromosome regions 12p11 and 12p13: similarity between parts of these genes and conserved human telomeric-associated DNA.	DDX12P DDX11	1.39e-05	2	130	2	8833153
Pubmed	Laminin-5 with transforming growth factor-beta1 induces epithelial to mesenchymal transition in hepatocellular carcinoma.	LAMC2 TGFB1	1.39e-05	2	130	2	16285938
Pubmed	Dynamics of the metal binding domains and regulation of the human copper transporters ATP7B and ATP7A.	ATP7A ATP7B	1.39e-05	2	130	2	28271598
Pubmed	[Structure and function of ATP7A and ATP7B proteins--Cu-transporting ATPases].	ATP7A ATP7B	1.39e-05	2	130	2	21117320
Pubmed	[From gene to disease: copper-transporting P ATPases alteration].	ATP7A ATP7B	1.39e-05	2	130	2	19046832
Pubmed	Expression in mouse kidney of membrane copper transporters Atp7a and Atp7b.	ATP7A ATP7B	1.39e-05	2	130	2	12372948
Pubmed	Altered localisation of the copper efflux transporters ATP7A and ATP7B associated with cisplatin resistance in human ovarian carcinoma cells.	ATP7A ATP7B	1.39e-05	2	130	2	18565219
Pubmed	Copper transporting P-type ATPases and human disease.	ATP7A ATP7B	1.39e-05	2	130	2	12539960
Pubmed	Mechanical loading induces primary cilia disassembly in tendon cells via TGFβ and HDAC6.	HDAC6 TGFB1	1.39e-05	2	130	2	30038235
Pubmed	Hormonal regulation of the Menkes and Wilson copper-transporting ATPases in human placental Jeg-3 cells.	ATP7A ATP7B	1.39e-05	2	130	2	17109627
Pubmed	Quantitative relationship between mutated amino-acid sequence of human copper-transporting ATPases and their related diseases.	ATP7A ATP7B	1.39e-05	2	130	2	18688737
Pubmed	Impaired neurogenesis and cardiovascular development in mice lacking the E3 ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway.	UBR1 UBR2	1.39e-05	2	130	2	16606826
Pubmed	c-Met Signaling Is Essential for Mouse Adult Liver Progenitor Cells Expansion After Transforming Growth Factor-β-Induced Epithelial-Mesenchymal Transition and Regulates Cell Phenotypic Switch.	TGFB1 MET	1.39e-05	2	130	2	31108004
Pubmed	Expression and localization of menkes and Wilson copper transporting ATPases in human placenta.	ATP7A ATP7B	1.39e-05	2	130	2	15135234
Pubmed	Developmental expression of the mouse mottled and toxic milk genes suggests distinct functions for the Menkes and Wilson disease copper transporters.	ATP7A ATP7B	1.39e-05	2	130	2	9215673
Pubmed	Regulatory mechanisms and pathophysiological significance of IP3 receptors and ryanodine receptors in drug dependence.	RYR2 ITPR3	1.39e-05	2	130	2	24285081
Pubmed	Regulation of protein catabolism by muscle-specific and cytokine-inducible ubiquitin ligase E3alpha-II during cancer cachexia.	UBR1 UBR2	1.39e-05	2	130	2	15548684
Pubmed	Copper-transporting ATPases ATP7A and ATP7B: cousins, not twins.	ATP7A ATP7B	1.39e-05	2	130	2	18000748
Pubmed	Warsaw Breakage Syndrome associated DDX11 helicase resolves G-quadruplex structures to support sister chromatid cohesion.	DDX12P DDX11	1.39e-05	2	130	2	32855419
Pubmed	Menkes disease: recent advances and new insights into copper metabolism.	ATP7A ATP7B	1.39e-05	2	130	2	8732640
Pubmed	ResolvinD1 stimulates epithelial wound repair and inhibits TGF-β-induced EMT whilst reducing fibroproliferation and collagen production.	GPR32 TGFB1	1.39e-05	2	130	2	29083412
Pubmed	Rictor/mTORC2 signaling mediates TGFβ1-induced fibroblast activation and kidney fibrosis.	RICTOR TGFB1	1.39e-05	2	130	2	25970154
Pubmed	Trafficking of the copper-ATPases, ATP7A and ATP7B: role in copper homeostasis.	ATP7A ATP7B	1.39e-05	2	130	2	17531189
Pubmed	Intracellular targeting of copper-transporting ATPase ATP7A in a normal and Atp7b-/- kidney.	ATP7A ATP7B	1.39e-05	2	130	2	17928409
Pubmed	Structural basis of substrate recognition and specificity in the N-end rule pathway.	UBR1 UBR2	1.39e-05	2	130	2	20835242
Pubmed	Characterization of putative human homologues of the yeast chromosome transmission fidelity gene, CHL1.	DDX12P DDX11	1.39e-05	2	130	2	9013641
Pubmed	Requirement of HDAC6 for transforming growth factor-beta1-induced epithelial-mesenchymal transition.	HDAC6 TGFB1	1.39e-05	2	130	2	18499657
Pubmed	Characterization of two human genes encoding acyl coenzyme A:cholesterol acyltransferase-related enzymes.	SOAT2 DGAT1	4.15e-05	3	130	2	9756920
Pubmed	Differential activities, subcellular distribution and tissue expression patterns of three members of Slingshot family phosphatases that dephosphorylate cofilin.	SSH1 SSH2	4.15e-05	3	130	2	14531860
Pubmed	TGFβ1-induced Amelotin gene expression is downregulated by Bax expression in mouse gingival epithelial cells.	TGFB1 AMTN	4.15e-05	3	130	2	29657250
Pubmed	Loss of ChlR1 helicase in mouse causes lethality due to the accumulation of aneuploid cells generated by cohesion defects and placental malformation.	DDX12P DDX11	4.15e-05	3	130	2	17611414
Pubmed	ATP7A and ATP7B copper transporters have distinct functions in the regulation of neuronal dopamine-β-hydroxylase.	ATP7A ATP7B	4.15e-05	3	130	2	30341172
Pubmed	Identification of Ubr1 as an amino acid sensor of steatosis in liver and muscle.	UBR1 UBR2	4.15e-05	3	130	2	37057345
Pubmed	The copper-transporting ATPases, menkes and wilson disease proteins, have distinct roles in adult and developing cerebellum.	ATP7A ATP7B	4.15e-05	3	130	2	15634671
Pubmed	Interaction of the copper chaperone HAH1 with the Wilson disease protein is essential for copper homeostasis.	ATP7A ATP7B	4.15e-05	3	130	2	10557326
Pubmed	Mammalian ChlR1 has a role in heterochromatin organization.	DDX12P DDX11	4.15e-05	3	130	2	21854770
Pubmed	Role of glutaredoxin1 and glutathione in regulating the activity of the copper-transporting P-type ATPases, ATP7A and ATP7B.	ATP7A ATP7B	4.15e-05	3	130	2	20566629
Pubmed	Characterization of the interaction between the Wilson and Menkes disease proteins and the cytoplasmic copper chaperone, HAH1p.	ATP7A ATP7B	4.15e-05	3	130	2	10497213
Pubmed	Overexpression of c-Met and CD44v6 receptors contributes to autocrine TGF-β1 signaling in interstitial lung disease.	TGFB1 MET	4.15e-05	3	130	2	24324260
Pubmed	Identification of distinct inhibin and transforming growth factor beta-binding sites on betaglycan: functional separation of betaglycan co-receptor actions.	INHA TGFB1	4.15e-05	3	130	2	16621788
Pubmed	HDAC6 regulates microRNA-27b that suppresses proliferation, promotes apoptosis and target MET in diffuse large B-cell lymphoma.	HDAC6 MET	4.15e-05	3	130	2	29135973
Pubmed	Runt-Related Transcription Factor 1 (RUNX1) Promotes TGF-β-Induced Renal Tubular Epithelial-to-Mesenchymal Transition (EMT) and Renal Fibrosis through the PI3K Subunit p110δ.	TGFB1 PIK3CD	4.15e-05	3	130	2	29759484
Pubmed	Copper-dependent interaction of glutaredoxin with the N termini of the copper-ATPases (ATP7A and ATP7B) defective in Menkes and Wilson diseases.	ATP7A ATP7B	4.15e-05	3	130	2	16884690
Pubmed	The V-ATPase a2 isoform controls mammary gland development through Notch and TGF-β signaling.	TGFB1 ATP6V0A2	4.15e-05	3	130	2	27809299
Pubmed	Expression and significance of CD44, CD47 and c-met in ovarian clear cell carcinoma.	MET CD47	4.15e-05	3	130	2	25658794
Pubmed	The Wilson disease protein ATP7B resides in the late endosomes with Rab7 and the Niemann-Pick C1 protein.	NPC1 ATP7B	4.15e-05	3	130	2	15681833
Pubmed	Intestinal expression of metal transporters in Wilson's disease.	ATP7A ATP7B	4.15e-05	3	130	2	23963605
Pubmed	RECQL4, mutated in the Rothmund-Thomson and RAPADILINO syndromes, interacts with ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway.	UBR1 UBR2	4.15e-05	3	130	2	15317757
Pubmed	NT5E and FcGBP as key regulators of TGF-1-induced epithelial-mesenchymal transition (EMT) are associated with tumor progression and survival of patients with gallbladder cancer.	TGFB1 FCGBP	4.15e-05	3	130	2	24310606
Pubmed	Clusterin (apolipoprotein J), a molecular chaperone that facilitates degradation of the copper-ATPases ATP7A and ATP7B.	ATP7A ATP7B	4.15e-05	3	130	2	21242307
Pubmed	Decreased Expression of the Slc31a1 Gene and Cytoplasmic Relocalization of Membrane CTR1 Protein in Renal Epithelial Cells: A Potent Protective Mechanism against Copper Nephrotoxicity in a Mouse Model of Menkes Disease.	ATP7A SLC31A2	4.15e-05	3	130	2	36232742
Pubmed	Negative control of the HGF/c-MET pathway by TGF-β: a new look at the regulation of stemness in glioblastoma.	TGFB1 MET	4.15e-05	3	130	2	29238047
Pubmed	Copper chaperone Atox1 interacts with the metal-binding domain of Wilson's disease protein in cisplatin detoxification.	ATP7A ATP7B	4.15e-05	3	130	2	23751120
Pubmed	METTL3/IGF2BP1/CD47 contributes to the sublethal heat treatment induced mesenchymal transition in HCC.	IGF2BP1 CD47	4.15e-05	3	130	2	33582561
Pubmed	Human hepatic sinusoidal endothelial cells can be distinguished by expression of phenotypic markers related to their specialised functions in vivo.	CLEC4M STAB1	4.15e-05	3	130	2	17006978
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	NPC1 USP34 FRAS1 ABR NLRX1 HECTD4 MLLT10 ITPR3 VAC14 SSH1 SETD5 PIK3CD COQ4 INTS11	7.03e-05	1105	130	14	35748872
Pubmed	mTORC1-independent autophagy regulates receptor tyrosine kinase phosphorylation in colorectal cancer cells via an mTORC2-mediated mechanism.	RICTOR MET	8.28e-05	4	130	2	28475179
Pubmed	Genomic organization of the mottled gene, the mouse homologue of the human Menkes disease gene.	ATP7A ATP7B	8.28e-05	4	130	2	8921375
Pubmed	A family of mammalian E3 ubiquitin ligases that contain the UBR box motif and recognize N-degrons.	UBR1 UBR2	8.28e-05	4	130	2	16055722
Pubmed	The ATF3 Transcription Factor Is a Short-Lived Substrate of the Arg/N-Degron Pathway.	UBR1 UBR2	8.28e-05	4	130	2	32692156
Pubmed	TGF-β-induced activation of mTOR complex 2 drives epithelial-mesenchymal transition and cell invasion.	RICTOR TGFB1	8.28e-05	4	130	2	22399812
Pubmed	The slingshot family of phosphatases mediates Rac1 regulation of cofilin phosphorylation, laminin-332 organization, and motility behavior of keratinocytes.	SSH1 SSH2	8.28e-05	4	130	2	17848544
Pubmed	Construction and analysis of mouse strains lacking the ubiquitin ligase UBR1 (E3alpha) of the N-end rule pathway.	UBR1 UBR2	8.28e-05	4	130	2	11689692
Pubmed	Overexpression of human diacylglycerol acyltransferase 1, acyl-coa:cholesterol acyltransferase 1, or acyl-CoA:cholesterol acyltransferase 2 stimulates secretion of apolipoprotein B-containing lipoproteins in McA-RH7777 cells.	SOAT2 DGAT1	8.28e-05	4	130	2	15308631
Pubmed	Female lethality and apoptosis of spermatocytes in mice lacking the UBR2 ubiquitin ligase of the N-end rule pathway.	UBR1 UBR2	8.28e-05	4	130	2	14585983
Pubmed	Clusterin and COMMD1 independently regulate degradation of the mammalian copper ATPases ATP7A and ATP7B.	ATP7A ATP7B	8.28e-05	4	130	2	22130675
Pubmed	The substrate recognition domains of the N-end rule pathway.	UBR1 UBR2	8.28e-05	4	130	2	19008229
Pubmed	Dual role of LRRC8A-containing transporters on cisplatin resistance in human ovarian cancer cells.	ATP7A ATP7B	8.28e-05	4	130	2	27112899
Pubmed	An essential role of N-terminal arginylation in cardiovascular development.	UBR1 UBR2	8.28e-05	4	130	2	12098698
Pubmed	The N-end rule pathway counteracts cell death by destroying proapoptotic protein fragments.	UBR1 UBR2	8.28e-05	4	130	2	22670058
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	HDAC6 NUP107 NLRX1 ATG2B RICTOR PSMD13 IDH3A HM13 TUBGCP5 RIF1	9.83e-05	606	130	10	36538041
Pubmed	Distinct recruitment of Eps15 via Its coiled-coil domain is required for efficient down-regulation of the met receptor tyrosine kinase.	TGFB1 MET	1.38e-04	5	130	2	19109251
Pubmed	Molecular basis for differential modulation of BK channel voltage-dependent gating by auxiliary γ subunits.	LRRC52 LRRC55	1.38e-04	5	130	2	26009545
GeneFamily	ATPase copper transporting	ATP7A ATP7B	1.65e-05	2	74	2	1212
GeneFamily	Slingshot protein phosphatases	SSH1 SSH2	4.94e-05	3	74	2	898
GeneFamily	Ubiquitin protein ligase E3 component n-recognins	UBR1 UBR2	3.42e-04	7	74	2	785
Coexpression	BUSSLINGER_GASTRIC_IMMUNE_CELLS	USP34 UBR1 UBR2 XRN2 DOCK8 GNPTAB HECTD4 USP24 RICTOR BTN3A1 TGFB1 RIF1 SSH1 SETD5 PIK3CD TBC1D1 RABGAP1L TMC8 CD47 TMEM131L SSH2 ACAP2 VPS13B	8.56e-07	1492	128	23	M40023
Coexpression	GSE43863_TFH_VS_LY6C_LOW_CXCR5NEG_EFFECTOR_CD4_TCELL_UP	ACP6 RICTOR IDH3A ADCY6 DDX11 TMEM168 CD47 ZDHHC13	6.30e-06	199	128	8	M9750
ToppCell	356C-Myeloid-Macrophage-SPP1+_Macrophage\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	CNNM2 EPS8L1 ZCCHC2 DIPK2A AIFM2 NOP14 COQ4	5.45e-07	164	130	7	d6806deabf5f5c355934387be2baae125ac33fb8
ToppCell	CV-Moderate-7\|Moderate / Virus stimulation, Condition and Cluster	NPC1 UBR2 DOCK8 TMEM161B GNPTAB DIPK2A TMEM131L	1.22e-06	185	130	7	a6c9203ce6c2892a4a369c9bcfb85720f01cbb3f
ToppCell	CV-Moderate-7\|CV / Virus stimulation, Condition and Cluster	NPC1 UBR2 DOCK8 TMEM161B GNPTAB DIPK2A TMEM131L	1.27e-06	186	130	7	8571956890fc9894d766ba294a28e376b4aba428
ToppCell	mild-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	NPC1 USP34 UBR2 GNPTAB USP24 RICTOR VPS13B	1.99e-06	199	130	7	f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCell	droplet-Marrow-nan-24m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATP7A RAB44 PEX26 S1PR5 SSH2 MFSD13A	1.01e-05	168	130	6	e979a4fbeb9f21048b47d69e6da75c57650697f2
ToppCell	droplet-Marrow-nan-3m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATP7A DOCK8 S1PR5 TBC1D1 SSH2 TMEM164	1.27e-05	175	130	6	cf53a15bfb37b6019e7052ffdf594a9ac040900e
ToppCell	-Unknown-Endothelial-Myofibroblast\| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	USP24 ADCY6 RYR2 SSH1 TMEM164 ANAPC5	1.91e-05	188	130	6	6468fa95ad0395395301115286f2d8c0df5d3882
ToppCell	-Unknown-Endothelial\| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	USP24 ADCY6 RYR2 SSH1 TMEM164 ANAPC5	1.91e-05	188	130	6	7a81ac5c79c3eb26639b52d2b9fd5e7ef9798fd6
ToppCell	-Unknown\| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	USP24 ADCY6 RYR2 SSH1 TMEM164 ANAPC5	1.91e-05	188	130	6	9cb718bfe1358c6fd842f096e228eb0abb9aefc6
ToppCell	3'-GW_trimst-1-SmallIntestine-Hematopoietic-Myeloid-CLC+_Mast_cell\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	EPX RAB44 SPATC1 PROX2 TMC8 ATP6V0A2	1.91e-05	188	130	6	ab95a97db1a84bf3e53a4616a83ee81a6ce5ec12
ToppCell	PCW_07-8.5-Hematologic_Myeloid-Hem_Myeloid_monocytic-im_myeloid_progenitor1_(6)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	DOCK8 SLCO2B1 STAB1 FCGBP PIK3CD TMC8	2.02e-05	190	130	6	773c55b9e28c2f77a5eb5f0adb0fa9862fb9611d
ToppCell	CD8+_Memory_T_cell-CV-7\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	UBR1 UBR2 TMEM161B GNPTAB DIPK2A TMEM131L	2.09e-05	191	130	6	9454f642c3621370fa23640b631301346b300950
ToppCell	facs-Brain_Myeloid-Hippocampus-3m-Myeloid\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK8 SLCO2B1 USP24 STAB1 SSH2 ACAP2	2.21e-05	193	130	6	06b65110db974f4ef90d3511ff34428976a52c9c
ToppCell	facs-Brain_Myeloid-Hippocampus-3m-Myeloid-microglial_cell\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK8 SLCO2B1 USP24 STAB1 SSH2 ACAP2	2.21e-05	193	130	6	9c16032bc03df8760ae199e8f19fdafa4c3f1827
ToppCell	facs-Brain_Myeloid-Hippocampus-3m\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK8 SLCO2B1 USP24 STAB1 SSH2 ACAP2	2.21e-05	193	130	6	a4f91bca5eaa985982d33a528f7566ffde154d47
ToppCell	facs-Brain_Myeloid-Hippocampus-3m-Myeloid-nan\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK8 SLCO2B1 USP24 STAB1 SSH2 ACAP2	2.21e-05	193	130	6	b39d7feaac4ff8f7409cd3d15e8f3c6391367275
ToppCell	Children_(3_yrs)-Immune\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ABR DOCK8 SLCO2B1 PIK3CD TMC8 TMEM131L	2.48e-05	197	130	6	f18807124b91310fcd84238484a80ecdba684679
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ABR DOCK8 SLCO2B1 STAB1 PIK3CD TMC8	2.48e-05	197	130	6	61ef3f417767c3f5296a26399da63e3e4f58faf8
ToppCell	Parenchymal-NucSeq-Immune_Lymphocytic-NK-ILC-T_NK-NK_CD11d\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DOCK8 CLEC4M BTN3A1 S1PR5 PIK3CD TMC8	2.63e-05	199	130	6	7d69785717073491b5fb81bf24db0175f86cd0b0
ToppCell	Control-Epithelial_alveolar-Mes-Like-Differentiating_AT1\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RAB44 SPATC1 IGF2BP1 AIFM2 SLITRK6	3.57e-05	127	130	5	556aaf88719c83f307fa50dfac151136ed05c8ad
Drug	Benfotiamine [22457-89-2]; Up 200; 8.6uM; MCF7; HT_HG-U133A	ABR GNPTAB CASP2 MFSD9 BTN3A1 MET RIF1 NME5 NPAS2	1.82e-06	196	129	9	3837_UP
Disease	Amelogenesis Imperfecta	LAMC2 PEX26 AMTN	1.70e-05	12	128	3	C0002452
Disease	occipital horn syndrome (implicated_via_orthology)	ATP7A ATP7B	1.87e-05	2	128	2	DOID:0111272 (implicated_via_orthology)
Disease	Warsaw breakage syndrome (implicated_via_orthology)	DDX12P DDX11	5.59e-05	3	128	2	DOID:0060535 (implicated_via_orthology)
Disease	C-reactive protein measurement	NPC1 USP34 UBR2 LINC00862 RICTOR MLLT10 ZCCHC2 SMYD2 LRRC55 IGF2BP1 SETD5 TBC1D1 SLITRK6 CCDC171 ANAPC5 DNAH11	6.94e-05	1206	128	16	EFO_0004458
Disease	metal metabolism disorder (implicated_via_orthology)	ATP7A ATP7B	1.11e-04	4	128	2	DOID:896 (implicated_via_orthology)
Disease	Hepatitis, Chronic	ATP7A TGFB1 MET	1.16e-04	22	128	3	C0019189
Disease	Chronic active hepatitis	ATP7A TGFB1 MET	1.16e-04	22	128	3	C0520463
Disease	Chronic Persistent Hepatitis	ATP7A TGFB1 MET	1.16e-04	22	128	3	C0149519
Disease	Cryptogenic Chronic Hepatitis	ATP7A TGFB1 MET	1.16e-04	22	128	3	C0524611
Disease	Wilson disease (implicated_via_orthology)	ATP7A ATP7B	1.85e-04	5	128	2	DOID:893 (implicated_via_orthology)
Disease	Menkes disease (implicated_via_orthology)	ATP7A ATP7B	1.85e-04	5	128	2	DOID:1838 (implicated_via_orthology)
Disease	myeloid white cell count	NPC1 USP34 UBR2 SLC31A2 DOCK8 LINC00862 HECTD4 CLEC4M ZCCHC2 MET RABGAP1L SSH2 MFSD13A	2.25e-04	937	128	13	EFO_0007988
Disease	brain connectivity measurement	CNNM2 ACTRT2 MLLT10 BTN3A1 MET SSH1 SSH2 MFSD13A	3.70e-04	400	128	8	EFO_0005210
Disease	Lung diseases	DOCK8 TGFB1 STRA6 DNAH11	3.76e-04	78	128	4	C0024115
Disease	lysosomal protective protein measurement	GNPTAB TMEM131L	3.87e-04	7	128	2	EFO_0008215
Disease	neutrophil count, basophil count	NPC1 UBR2 DOCK8 HECTD4 PCDHA11 CLEC4M	4.49e-04	224	128	6	EFO_0004833, EFO_0005090
Disease	proteoglycan 3 measurement	USP34 AIFM2	5.14e-04	8	128	2	EFO_0802970
Disease	spinal muscular atrophy (implicated_via_orthology)	ATP7A ATP7B	6.59e-04	9	128	2	DOID:12377 (implicated_via_orthology)
Disease	neutrophil count	NPC1 UBR2 SLC31A2 DOCK8 LINC00862 HECTD4 PCDHA11 CLEC4M ZCCHC2 LRRC52 MET RABGAP1L SSH2 MFSD13A ATP6V0A2	9.80e-04	1382	128	15	EFO_0004833
Disease	Copper-Overload Cirrhosis	TGFB1 MET	1.00e-03	11	128	2	C1876165
Disease	Liver Cirrhosis	NPC1 ATP7B LAMC2 TGFB1	1.07e-03	103	128	4	C0023890
Disease	Fibrosis, Liver	NPC1 ATP7B LAMC2 TGFB1	1.15e-03	105	128	4	C0239946
Disease	eosinophil measurement	USP34 AIFM2 PELP1 TMEM131L	1.28e-03	108	128	4	EFO_0803540
Disease	Hepatoma, Morris	ATP7A ATP7B TGFB1 MET	1.37e-03	110	128	4	C0019207
Disease	Hepatoma, Novikoff	ATP7A ATP7B TGFB1 MET	1.37e-03	110	128	4	C0019208
Disease	Experimental Hepatoma	ATP7A ATP7B TGFB1 MET	1.37e-03	110	128	4	C0086404
Disease	Liver Neoplasms, Experimental	ATP7A ATP7B TGFB1 MET	1.37e-03	110	128	4	C0023904
Disease	cholangiocarcinoma (biomarker_via_orthology)	TGFB1 MET	1.41e-03	13	128	2	DOID:4947 (biomarker_via_orthology)
Disease	alcohol use disorder (implicated_via_orthology)	EPS8L1 RYR2 SSH1 PIK3CD SSH2	1.64e-03	195	128	5	DOID:1574 (implicated_via_orthology)
Disease	Carcinoma, Granular Cell	TGFB1 MET EEF2 ROBO1	1.66e-03	116	128	4	C0205644
Disease	Adenocarcinoma, Tubular	TGFB1 MET EEF2 ROBO1	1.66e-03	116	128	4	C0205645
Disease	Adenocarcinoma, Oxyphilic	TGFB1 MET EEF2 ROBO1	1.66e-03	116	128	4	C0205642
Disease	Carcinoma, Cribriform	TGFB1 MET EEF2 ROBO1	1.66e-03	116	128	4	C0205643
Disease	Adenocarcinoma, Basal Cell	TGFB1 MET EEF2 ROBO1	1.66e-03	116	128	4	C0205641
Disease	Adenocarcinoma	TGFB1 MET EEF2 ROBO1	1.66e-03	116	128	4	C0001418
Disease	von Willebrand factor measurement, coronary artery disease	CNNM2 HECTD4 CLEC4M TGFB1	1.77e-03	118	128	4	EFO_0001645, EFO_0004629
Disease	hepcidin:transferrin saturation ratio	LINC00862 NLRP6	1.89e-03	15	128	2	EFO_0007902
Disease	Tremor, Rubral	NPC1 ATP7A	2.15e-03	16	128	2	C0750940
Disease	Ataxia, Appendicular	NPC1 ATP7A	2.15e-03	16	128	2	C0750937
Disease	Ataxia, Motor	NPC1 ATP7A	2.15e-03	16	128	2	C0278161
Disease	lung small cell carcinoma (is_marker_for)	RICTOR EEF2	2.15e-03	16	128	2	DOID:5409 (is_marker_for)
Disease	Ataxia, Sensory	NPC1 ATP7A	2.15e-03	16	128	2	C0240991
Disease	Abnormal coordination	NPC1 ATP7A	2.15e-03	16	128	2	C0520966
Disease	Ataxia, Truncal	NPC1 ATP7A	2.15e-03	16	128	2	C0427190
Disease	serum gamma-glutamyl transferase measurement	UBR1 LINC00862 HECTD4 RYR2 STAB1 TGFB1 MET SSH1 ROBO1 CCDC171 ANAPC5	2.15e-03	914	128	11	EFO_0004532
Disease	multiple myeloma (is_implicated_in)	TGFB1 MET ROBO1	2.17e-03	59	128	3	DOID:9538 (is_implicated_in)
Disease	Sarcomatoid Renal Cell Carcinoma	CASP2 MLLT10 MET EEF2	2.38e-03	128	128	4	C1266043
Disease	Chromophobe Renal Cell Carcinoma	CASP2 MLLT10 MET EEF2	2.38e-03	128	128	4	C1266042
Disease	Collecting Duct Carcinoma of the Kidney	CASP2 MLLT10 MET EEF2	2.38e-03	128	128	4	C1266044
Disease	Papillary Renal Cell Carcinoma	CASP2 MLLT10 MET EEF2	2.38e-03	128	128	4	C1306837
Disease	Renal Cell Carcinoma	CASP2 MLLT10 MET EEF2	2.38e-03	128	128	4	C0007134
Disease	hearing threshold measurement, hearing measurement	SLC31A2 TBC1D1 UBQLN3	2.39e-03	61	128	3	EFO_0007616, EFO_0007618
Disease	neutrophil count, eosinophil count	NPC1 UBR2 DOCK8 HECTD4 CLEC4M	2.41e-03	213	128	5	EFO_0004833, EFO_0004842
Disease	cholangiocarcinoma (is_marker_for)	HDAC6 TGFB1 MET	2.74e-03	64	128	3	DOID:4947 (is_marker_for)
Disease	cortical thickness	CNNM2 ACTRT2 MLLT10 RAB44 STAB1 IGF2BP1 SETD5 PROX2 ROBO1 SSH2 CCDC171 ANKFN1	3.36e-03	1113	128	12	EFO_0004840
Disease	bipolar disorder	ZCCHC2 TUBGCP5 BTN3A1 PALB2 INSC C15orf32 CD47 CMTR2	3.76e-03	577	128	8	MONDO_0004985
Disease	non-high density lipoprotein cholesterol measurement	NPC1 USP34 LAMC2 EPX ARSL SSH1 RABGAP1L PROX2 DNAH11	3.98e-03	713	128	9	EFO_0005689
Disease	Conventional (Clear Cell) Renal Cell Carcinoma	CASP2 MLLT10 MET EEF2	4.01e-03	148	128	4	C0279702
Disease	Bronchiectasis	PIK3CD DNAH11	4.07e-03	22	128	2	C0006267
Disease	gait measurement	NPC1 MLLT10 IGF2BP1 SETD5	4.20e-03	150	128	4	EFO_0007680

Protein segments in the cluster

Peptide	Gene	Start	Entry
MSLHNLATVFGPTLL	ABR	791	Q12979
HIPLITMENFLGKSL	ARSL	301	P51690
LQLLMPHSAQFSVLG	BTN3A1	21	O00481
ELLMQLLLASGHTFP	ACTRT2	191	Q8TDY3
IQLLIFPHSTLMLGI	ADCY6	686	O43306
SMVLDHNIIPGLSIL	ATP7B	681	P35670
QLPKLHLETFAMEGL	CCDC171	1176	Q6TFL3
HPRMLLILQASFALG	GPR32	291	O75388
IHPLLSKMTLNFGTE	CMTR2	326	Q8IYT2
FEGIDSHMLLQQPLI	DNAH11	2771	Q96DT5
LTQMLTLGPDLHLLN	AMTN	56	Q6UX39
SMFLDSKHLNPGLQL	ACAP2	596	Q15057
PVGSLLALMAHTILF	DGAT1	191	O75907
APSHLMALLTLGINS	ACTR10	121	Q9NZ32
QVHLLLDMLAAIAGP	ATG2B	326	Q96BY7
HSSMFLERQILPGLS	ATP7A	696	Q04656
LAFMEQLGTGHLLPK	RAB44	151	Q7Z6P3
NLPGHLLRFMTHLIL	NUP107	541	P57740
HLFLTPGLLEAETMQ	ITPR3	1251	Q14573
ELQEALTLLIHGSPM	NOX5	81	Q96PH1
LLGHLPSDVMDQNLL	NPAS2	116	Q99743
LSLLHMAIEPILADG	ANAPC5	641	Q9UJX4
LMSIKPNGRHLFTLD	PCDHA11	281	Q9Y5I1
GLLHMVLLSIPFFSI	ORMDL2	31	Q53FV1
LAALLAMPTLSFSHL	P2RY11	156	Q96G91
LDSHTLIMGDFNTPL	nan	136	O00370
LHNNSLMELPRGLFL	LRRC55	96	Q6ZSA7
IDSTLHQPMFLLLAI	OR52W1	56	Q6IF63
HQPMFLLLAILAATD	OR52W1	61	Q6IF63
ISTMPLHNLHFLLSE	FRAS1	3351	Q86XX4
PLSLQDLTGLEHMLI	GNPTAB	1041	Q3T906
DLFGVSMVVPLLSLH	MFSD9	56	Q8NBP5
PRLLHGTLIMKDSNF	INTS11	476	Q5TA45
QPVTHLIFDMDGLLL	PUDP	6	Q08623
AAMSLQSHLIPGLNL	IGF2BP1	356	Q9NZI8
MHLLPALAGVLATLV	EPX	1	P11678
LEGSVSHKFLSLPML	PEX26	221	Q7Z412
LNLHIMPTLLEGLTE	NME5	161	P56597
TSLPAMHLGLLSDLV	LRRC52	66	Q8N7C0
DLGLLLLFVGQHSLM	NRM	66	Q8IXM6
SFPHLESLALSLMAG	TUBGCP5	1006	Q96RT8
VLGILALSHTISPFM	HM13	111	Q8TCT9
FNFGELLMHPVLESL	PSMD13	211	Q9UNM6
VLPLMAAAGSHLLFV	NLRX1	226	Q86UT6
SPLMHIQGFLAALTT	DDX11	561	Q96FC9
ATMLGHLLPVLLTSL	HECTD4	536	Q9Y4D8
IALLHSLLMAPESNA	HECTD4	1666	Q9Y4D8
IMGPLQALLTDHLAD	NOP14	711	P78316
DISMNHLPGLLTSLL	PELP1	171	Q8IZL8
GHLLLAALDMPFTLL	GPR78	51	Q96P69
LLGELLHMANTILPH	RICTOR	426	Q6R327
QGQSFLAAVLLLHMP	RABGAP1L	621	Q5R372
LPATMFHLLLAARSG	TM7SF2	26	O76062
AMVLLGATHGLIFLP	NPC1	1231	O15118
PFHRDGMLSLKQLLS	PALB2	591	Q86YC2
MEALPFSLLHIQEGL	PROX2	426	Q3B8N5
PGSKQEFLSLLMQHL	G2E3	406	Q7L622
GHPSMNLLLRKTFDL	IDH3A	106	P50213
PVDFEGLLMTHLNSL	DOCK8	61	Q8NF50
RLLFDGDAHLLMSIP	FCGBP	4961	Q9Y6R7
LGSLLVLMVLHSPSL	DIPK2A	21	Q8NDZ4
HSPAGMALSVLVLLL	SLC31A2	21	O15432
LHTLLGMPTNILGEI	COQ4	166	Q9Y3A0
PLMHIEGFLAALTTA	DDX12P	581	Q92771
GELFSSPHLQMLLNP	HAUS7	166	Q99871
MVLHLLLFLLLTPQG	INHA	1	P05111
SMLGQHFGQLLELAL	INSC	221	Q1MX18
LGLPTNLTHILLFGM	GP5	46	P40197
TLDGLLHLMDQPLSV	LAMC2	1101	Q13753
AGDALLQMITIHLPS	EEF2	346	P13639
FHGTLALAPMLEVAL	EMC8	61	O43402
MHGPLLISGLSILAL	CD47	266	Q08722
MAATPAGFAQLTHLL	HDAC6	356	Q9UBN7
SSPELLHFLFGPLQM	EPS8L1	341	Q8TE68
RFHAPMFLLLGSLTL	S1PR5	66	Q9H228
LTEPVLHGDLMAFIQ	SBK2	136	P0C263
LLPMLSSLFEHIGQH	RYR2	3101	Q92736
SLLMLLAGPDHLSLL	MFSD13A	346	Q14CX5
DMLLTTLSGLQHVLP	CASP2	116	P42575
LPASLLHPLFQAMTD	NLRP6	711	P59044
MLVLLPQLAEAHGTS	OTOG	1991	Q6ZRI0
MAGENHTTLPEFLLL	OR10P1	1	Q8NGE3
MKDFSHPNVLSLLGI	MET	1131	P08581
LMLLPQSSAFQLLSH	VAC14	701	Q08AM6
LQSHPTVMLFALIAL	RSPRY1	236	Q96DX4
MSPLLFQAQPLSHLE	SPATA31C2	316	B4DYI2
PFQLSLLNNGLTMLH	SLITRK6	66	Q9H5Y7
MQESLLHFPGGLILI	TCP11X2	346	Q5H9J9
SRFGILHLHLQPLEM	TMEM131L	671	A2VDJ0
AFLTFPGLRLAQMHL	TMEM161B	241	Q8NDZ6
MVLLQGGEALPFSHL	AIFM2	91	Q9BRQ8
GLEMLLHFLLGPEAL	RIF1	431	Q5UIP0
ELLEHLSPGLALGAM	POU4F2	191	Q12837
LHPFGSDIAMLQLHL	PRSS47P	166	A8MTI9
ALILMPSLHCFGNIL	LINC00862	51	A6NCI5
VLATTLNMLPGLIHS	SETD5	731	Q9C0A6
PILANFLHIMAVILG	NKAIN1	36	Q4KMZ8
TTALAFLVLMPVLHG	STRA6	446	Q9BX79
LVLSILHATLPGIFM	SOAT2	336	O75908
LILGQMDKPSLIFDH	SSH1	301	Q8WYL5
TPSDILGMLKSLHQL	MLLT10	736	P55197
VLEMGHNVSFLLLLP	ANKFN1	711	Q8N957
LGHGALVLQLLSFML	CLEC4M	46	Q9H2X3
EMLSILALVGVLHPF	C15orf32	56	Q32M92
SPQLLLAMHRFLATE	CNNM2	621	Q9H8M5
QEELLLLFTMASLHP	ZCCHC2	256	Q9C0B9
SHAFSFPLLIMLSLV	TMC8	596	Q8IU68
MVILLLQHGADPTLI	ZDHHC13	131	Q8IUH4
SVMHSIFSLLGLLGE	RHCE	326	P18577
LKLLQPFLRTDSGMH	SSH2	1286	Q76I76
AQAIGLLLELLHSPM	RSPH14	271	Q9UHP6
ALAGLLMTLPHFISE	SLCO2B1	126	O94956
TVHPGMLADALLLLS	SPATC1	561	Q76KD6
MHAALAGPLLAALLA	TRABD2B	1	A6NFA1
HMLNGALLALLFPVV	TMEM164	151	Q5U3C3
DLATIHGMNRPFLLL	TGFB1	246	P01137
LIMLGLATHEPNFTI	XRN2	236	Q9H0D6
QGLSFVAGILLLHMS	TBC1D1	891	Q86TI0
HMLQILLTVDTGLPL	UBR1	1446	Q8IWV7
HLFALMRAAGLPELS	PIK3CD	976	O00329
MAFNGIIHALASPLL	STAB1	2446	Q9NY15
SLQMAVGPFLHILES	ACP6	296	Q9NPH0
VTFIPLLMTLGIFDH	ACP6	336	Q9NPH0
TMHGTFVILLPLSLI	TMEM114	101	B3SHH9
MISLLSLSPNHLFLA	ROBO1	11	Q9Y6N7
FLIVLPLESMAHGLF	TMEM168	386	Q9H0V1
SLPSVLVIHLMRFGF	USP24	1876	Q9UPU5
TISMAEFNLLDHLLP	VPS13B	651	Q7Z7G8
LMDGSPHFLHEILLS	VPS13B	1481	Q7Z7G8
FGRPLLLSALHMLVA	SLC35E4	76	Q6ICL7
MLLLLQEPHLTTLFD	USP34	1341	Q70CQ2
LSHLGSAIFPDVALM	SMYD2	191	Q9NRG4
IDMFHLLVGLVLAFP	UBR2	1411	Q8IWV8
IGVLFPSAEVALLMH	UHRF1BP1	871	Q6BDS2
AELGFLSPPFLHMLQ	UBQLN3	586	Q9H347
MFLFALLLVLNENHP	ATP6V0A2	421	Q9Y487