Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	P-type calcium transporter activity	ATP2B1 ATP2B2 ATP2B3	9.98e-06	11	80	3	GO:0005388
GeneOntologyMolecularFunction	calcium ion transmembrane transporter activity	PKD2 CACNA1G ATP2B1 ATP2B2 ATP2B3	3.53e-04	151	80	5	GO:0015085
GeneOntologyMolecularFunction	UDP-glycosyltransferase activity	GALNT9 UGGT1 B3GALT6 B3GNT3 B3GAT3	3.75e-04	153	80	5	GO:0008194
GeneOntologyMolecularFunction	P-type transmembrane transporter activity	ATP2B1 ATP2B2 ATP2B3	4.02e-04	36	80	3	GO:0140358
GeneOntologyMolecularFunction	P-type ion transporter activity	ATP2B1 ATP2B2 ATP2B3	4.02e-04	36	80	3	GO:0015662
GeneOntologyBiologicalProcess	regulation of blood circulation	FFAR3 AGER GPR42 WDR35 CACNA1G ATP2B1 ATP2B2 ATP2B3	3.52e-05	326	79	8	GO:1903522
GeneOntologyBiologicalProcess	positive regulation of acute inflammatory response to non-antigenic stimulus	FFAR3 GPR42	4.33e-05	3	79	2	GO:0002879
GeneOntologyBiologicalProcess	regulation of acute inflammatory response to non-antigenic stimulus	FFAR3 GPR42	8.65e-05	4	79	2	GO:0002877
GeneOntologyBiologicalProcess	regulation of norepinephrine secretion	GHSR FFAR3 GPR42	1.32e-04	26	79	3	GO:0014061
GeneOntologyBiologicalProcess	acute inflammatory response to non-antigenic stimulus	FFAR3 GPR42	1.44e-04	5	79	2	GO:0002525
GeneOntologyBiologicalProcess	norepinephrine secretion	GHSR FFAR3 GPR42	1.65e-04	28	79	3	GO:0048243
GeneOntologyBiologicalProcess	regulation of transmission of nerve impulse	GHSR FFAR3 GPR42	1.65e-04	28	79	3	GO:0051969
GeneOntologyBiologicalProcess	regulation of G1/S transition of mitotic cell cycle	CDKN2B PKD2 MEPCE PIDD1 AMBRA1 TJP3	1.68e-04	213	79	6	GO:2000045
GeneOntologyBiologicalProcess	regulation of cardiac conduction	ATP2B1 ATP2B2 ATP2B3	1.84e-04	29	79	3	GO:1903779
GeneOntologyBiologicalProcess	positive regulation of neuronal action potential	FFAR3 GPR42	2.15e-04	6	79	2	GO:1904457
GeneOntologyBiologicalProcess	regulation of protein localization	GHSR TCAF1 DRD4 TRAPPC12 INPP5E FFAR3 GPR42 MEPCE APBB3 SAE1 RIPOR1 B3GAT3 NOTCH4	2.32e-04	1087	79	13	GO:0032880
Domain	ATP_Ca_trans_C	ATP2B1 ATP2B2 ATP2B3	3.02e-07	4	80	3	IPR022141
Domain	ATP_Ca_trans_C	ATP2B1 ATP2B2 ATP2B3	3.02e-07	4	80	3	PF12424
Domain	P-type_ATPase_IIB	ATP2B1 ATP2B2 ATP2B3	3.02e-07	4	80	3	IPR006408
Domain	-	ATP2B1 ATP2B2 ATP2B3	4.07e-05	16	80	3	1.20.1110.10
Domain	ATPase_P-typ_TM_dom	ATP2B1 ATP2B2 ATP2B3	4.07e-05	16	80	3	IPR023298
Domain	ATPase_P-typ_cation-transptr_C	ATP2B1 ATP2B2 ATP2B3	4.93e-05	17	80	3	IPR006068
Domain	Cation_ATPase_C	ATP2B1 ATP2B2 ATP2B3	4.93e-05	17	80	3	PF00689
Domain	Cation_ATPase_N	ATP2B1 ATP2B2 ATP2B3	5.90e-05	18	80	3	PF00690
Domain	Cation_ATPase_N	ATP2B1 ATP2B2 ATP2B3	5.90e-05	18	80	3	SM00831
Domain	ATPase_P-typ_cation-transptr_N	ATP2B1 ATP2B2 ATP2B3	6.98e-05	19	80	3	IPR004014
Domain	GPR40-rel_orph	FFAR3 GPR42	1.08e-04	4	80	2	IPR013312
Domain	ATPase_P-typ_cyto_domN	ATP2B1 ATP2B2 ATP2B3	4.49e-04	35	80	3	IPR023299
Domain	P_typ_ATPase	ATP2B1 ATP2B2 ATP2B3	4.88e-04	36	80	3	IPR001757
Domain	ATPase_P-typ_P_site	ATP2B1 ATP2B2 ATP2B3	4.88e-04	36	80	3	IPR018303
Domain	ATPASE_E1_E2	ATP2B1 ATP2B2 ATP2B3	4.88e-04	36	80	3	PS00154
Domain	ATPase_P-typ_transduc_dom_A	ATP2B1 ATP2B2 ATP2B3	5.29e-04	37	80	3	IPR008250
Domain	E1-E2_ATPase	ATP2B1 ATP2B2 ATP2B3	5.29e-04	37	80	3	PF00122
Domain	Hydrolase_3	ATP2B2 ATP2B3	7.97e-04	10	80	2	PF08282
Domain	WD40	WDR97 WDR35 FBXW4 AMBRA1 WDR41 DCAF4L1	8.56e-04	259	80	6	PF00400
Domain	WD40	WDR97 WDR35 FBXW4 AMBRA1 WDR41 DCAF4L1	1.02e-03	268	80	6	SM00320
Domain	WD40_repeat	WDR97 WDR35 FBXW4 AMBRA1 WDR41 DCAF4L1	1.10e-03	272	80	6	IPR001680
Domain	WD_REPEATS_1	WDR97 WDR35 FBXW4 AMBRA1 WDR41 DCAF4L1	1.23e-03	278	80	6	PS00678
Domain	WD_REPEATS_2	WDR97 WDR35 FBXW4 AMBRA1 WDR41 DCAF4L1	1.26e-03	279	80	6	PS50082
Domain	WD_REPEATS_REGION	WDR97 WDR35 FBXW4 AMBRA1 WDR41 DCAF4L1	1.26e-03	279	80	6	PS50294
Domain	WD40_repeat_dom	WDR97 WDR35 FBXW4 AMBRA1 WDR41 DCAF4L1	1.72e-03	297	80	6	IPR017986
Domain	Glyco_trans_31	B3GALT6 B3GNT3	2.09e-03	16	80	2	IPR002659
Domain	Galactosyl_T	B3GALT6 B3GNT3	2.09e-03	16	80	2	PF01762
Domain	-	WDR97 WDR35 FBXW4 AMBRA1 WDR41 DCAF4L1	3.05e-03	333	80	6	2.130.10.10
Domain	EF_HAND_2	CAPN13 PLCD3 SPTA1 PKD2 EFCAB2	3.14e-03	231	80	5	PS50222
Domain	WD40/YVTN_repeat-like_dom	WDR97 WDR35 FBXW4 AMBRA1 WDR41 DCAF4L1	3.14e-03	335	80	6	IPR015943
Domain	Spectrin	SYNE3 SPTA1	4.32e-03	23	80	2	PF00435
Domain	HAD-like_dom	ATP2B1 ATP2B2 ATP2B3	4.74e-03	79	80	3	IPR023214
Domain	-	GALNT9 UGGT1 B3GAT3	5.08e-03	81	80	3	3.90.550.10
Domain	-	CAPN13 PLCD3 SPTA1 PKD2 EFCAB2	5.26e-03	261	80	5	1.10.238.10
Domain	Nucleotide-diphossugar_trans	GALNT9 UGGT1 B3GAT3	6.39e-03	88	80	3	IPR029044
Domain	Spectrin_repeat	SYNE3 SPTA1	6.82e-03	29	80	2	IPR002017
Domain	HMGI/Y_DNA-bd_CS	BAZ2A PLEKHA4	7.77e-03	31	80	2	IPR000637
Domain	EF-hand-dom_pair	CAPN13 PLCD3 SPTA1 PKD2 EFCAB2	7.79e-03	287	80	5	IPR011992
Domain	Spectrin/alpha-actinin	SYNE3 SPTA1	8.27e-03	32	80	2	IPR018159
Domain	-	ATP2B1 ATP2B2	8.27e-03	32	80	2	3.40.1110.10
Domain	-	ATP2B1 ATP2B2	8.27e-03	32	80	2	2.70.150.10
Domain	SPEC	SYNE3 SPTA1	8.27e-03	32	80	2	SM00150
Pathway	REACTOME_REDUCTION_OF_CYTOSOLIC_CA_LEVELS	ATP2B1 ATP2B2 ATP2B3	1.82e-05	12	63	3	M27326
Pathway	REACTOME_REDUCTION_OF_CYTOSOLIC_CA_LEVELS	ATP2B1 ATP2B2 ATP2B3	2.99e-05	14	63	3	MM15052
Pathway	KEGG_CALCIUM_SIGNALING_PATHWAY	PLCD3 PHKA2 CACNA1G ATP2B1 ATP2B2 ATP2B3	1.39e-04	178	63	6	M2890
Pathway	KEGG_MEDICUS_REFERENCE_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_LINKAGE_TETRASACCHARIDE	B3GALT6 B3GAT3	1.95e-04	5	63	2	M47914
Pathway	REACTOME_PLATELET_CALCIUM_HOMEOSTASIS	ATP2B1 ATP2B2 ATP2B3	2.30e-04	27	63	3	MM15053
Pathway	REACTOME_PLATELET_CALCIUM_HOMEOSTASIS	ATP2B1 ATP2B2 ATP2B3	2.57e-04	28	63	3	M924
Pathway	WP_VITAMIN_DSENSITIVE_CALCIUM_SIGNALING_IN_DEPRESSION	ATP2B1 ATP2B2 ATP2B3	5.47e-04	36	63	3	M39831
Pubmed	Cell-specific expression of plasma membrane calcium ATPase isoforms in retinal neurons.	ATP2B1 ATP2B2 ATP2B3	5.23e-08	4	83	3	12209837
Pubmed	Expression and role of calcium-ATPase pump and sodium-calcium exchanger in differentiated trophoblasts from human term placenta.	ATP2B1 ATP2B2 ATP2B3	5.23e-08	4	83	3	12784250
Pubmed	Calcium pumps of plasma membrane and cell interior.	ATP2B1 ATP2B2 ATP2B3	5.23e-08	4	83	3	15101689
Pubmed	The plasma membrane calcium pump in health and disease.	ATP2B1 ATP2B2 ATP2B3	5.23e-08	4	83	3	23413890
Pubmed	Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes.	ATP2B1 ATP2B2 ATP2B3	5.23e-08	4	83	3	8245032
Pubmed	Plasma membrane calcium ATPases as critical regulators of calcium homeostasis during neuronal cell function.	ATP2B1 ATP2B2 ATP2B3	5.23e-08	4	83	3	10577388
Pubmed	Structural organization, ion transport, and energy transduction of P-type ATPases.	ATP2B1 ATP2B2 ATP2B3	5.23e-08	4	83	3	8634322
Pubmed	Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes.	ATP2B1 ATP2B2 ATP2B3	5.23e-08	4	83	3	7989379
Pubmed	Role of alternative splicing in generating isoform diversity among plasma membrane calcium pumps.	ATP2B1 ATP2B2 ATP2B3	5.23e-08	4	83	3	11152753
Pubmed	PMCA1 depletion in mouse eggs amplifies calcium signaling and impacts offspring growth†.	ATP2B1 ATP2B2 ATP2B3	5.23e-08	4	83	3	36130203
Pubmed	Developmental expression of the four plasma membrane calcium ATPase (Pmca) genes in the mouse.	ATP2B1 ATP2B2 ATP2B3	5.23e-08	4	83	3	10434059
Pubmed	Differential regulation of the apical plasma membrane Ca(2+) -ATPase by protein kinase A in parotid acinar cells.	ATP2B1 ATP2B2 ATP2B3	1.31e-07	5	83	3	17938178
Pubmed	Cardiac excitation-contraction coupling in the absence of Na(+) - Ca2+ exchange.	ATP2B1 ATP2B2 ATP2B3	2.61e-07	6	83	3	12767889
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PPP1R26 PLCD3 SCAF1 SPIRE2 SYNE3 SUGP2 TRAPPC12 INPP5E KSR2 APBB3 LRRC56 AMBRA1 RIPOR1 TJP3	3.38e-07	1105	83	14	35748872
Pubmed	Gene knockout studies of Ca2+-transporting ATPases.	ATP2B1 ATP2B2 ATP2B3	7.28e-07	8	83	3	10951186
Pubmed	Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.	CACNA1G ATP2B1 ATP2B2 ATP2B3	2.09e-06	38	83	4	30786075
Pubmed	Expression of the short chain fatty acid receptor GPR41/FFAR3 in autonomic and somatic sensory ganglia.	FFAR3 GPR42	5.63e-06	2	83	2	25637492
Pubmed	Selective tracking of FFAR3-expressing neurons supports receptor coupling to N-type calcium channels in mouse sympathetic neurons.	FFAR3 GPR42	5.63e-06	2	83	2	30478340
Pubmed	3-(4-Hydroxy-3-methoxyphenyl) propionic acid contributes to improved hepatic lipid metabolism via GPR41.	FFAR3 GPR42	5.63e-06	2	83	2	38040866
Pubmed	Genetic Inactivation of Free Fatty Acid Receptor 3 Impedes Behavioral Deficits and Pathological Hallmarks in the APPswe Alzheimer's Disease Mouse Model.	FFAR3 GPR42	5.63e-06	2	83	2	35408893
Pubmed	FFAR3 modulates insulin secretion and global gene expression in mouse islets.	FFAR3 GPR42	5.63e-06	2	83	2	26091414
Pubmed	GPR41 modulates insulin secretion and gene expression in pancreatic β-cells and modifies metabolic homeostasis in fed and fasting states.	FFAR3 GPR42	5.63e-06	2	83	2	27550964
Pubmed	Intestinal FFA3 mediates obesogenic effects in mice on a Western diet.	FFAR3 GPR42	5.63e-06	2	83	2	35858247
Pubmed	Butyrate and propionate protect against diet-induced obesity and regulate gut hormones via free fatty acid receptor 3-independent mechanisms.	FFAR3 GPR42	5.63e-06	2	83	2	22506074
Pubmed	Free fatty acid receptor 3 differentially contributes to β-cell compensation under high-fat diet and streptozotocin stress.	FFAR3 GPR42	5.63e-06	2	83	2	32073900
Pubmed	The effects of propionate and valerate on insulin responsiveness for glucose uptake in 3T3-L1 adipocytes and C2C12 myotubes via G protein-coupled receptor 41.	FFAR3 GPR42	5.63e-06	2	83	2	24748202
Pubmed	Mutation of alpha1G T-type calcium channels in mice does not change anesthetic requirements for loss of the righting reflex and minimum alveolar concentration but delays the onset of anesthetic induction.	ICAM5 CACNA1G	5.63e-06	2	83	2	17525593
Pubmed	The Cognitive Improvement and Alleviation of Brain Hypermetabolism Caused by FFAR3 Ablation in Tg2576 Mice Is Persistent under Diet-Induced Obesity.	FFAR3 GPR42	5.63e-06	2	83	2	36362376
Pubmed	Localization of two genes encoding plasma membrane Ca2+ ATPases isoforms 2 (ATP2B2) and 3 (ATP2B3) to human chromosomes 3p26-->p25 and Xq28, respectively.	ATP2B2 ATP2B3	5.63e-06	2	83	2	8187550
Pubmed	Roles of GPR41 and GPR43 in leptin secretory responses of murine adipocytes to short chain fatty acids.	FFAR3 GPR42	5.63e-06	2	83	2	20399779
Pubmed	Sequence polymorphisms provide a common consensus sequence for GPR41 and GPR42.	FFAR3 GPR42	5.63e-06	2	83	2	19630535
Pubmed	Male mice that lack the G-protein-coupled receptor GPR41 have low energy expenditure and increased body fat content.	FFAR3 GPR42	5.63e-06	2	83	2	23110765
Pubmed	The Intestinal Microbiota Contributes to the Ability of Helminths to Modulate Allergic Inflammation.	FFAR3 GPR42	5.63e-06	2	83	2	26522986
Pubmed	Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41.	FFAR3 GPR42	5.63e-06	2	83	2	14722361
Pubmed	Microbial short chain fatty acid metabolites lower blood pressure via endothelial G protein-coupled receptor 41.	FFAR3 GPR42	5.63e-06	2	83	2	27664183
Pubmed	Targeting of receptor for advanced glycation end products suppresses cyst growth in polycystic kidney disease.	AGER PKD2	5.63e-06	2	83	2	24515114
Pubmed	Human GPR42 is a transcribed multisite variant that exhibits copy number polymorphism and is functional when heterologously expressed.	FFAR3 GPR42	5.63e-06	2	83	2	26260360
Pubmed	G protein coupled receptor 41 regulates fibroblast activation in pulmonary fibrosis via Gαi/o and downstream Smad2/3 and ERK1/2 phosphorylation.	FFAR3 GPR42	5.63e-06	2	83	2	37019194
Pubmed	Short-chain fatty acid receptor GPR41-mediated activation of sympathetic neurons involves synapsin 2b phosphorylation.	FFAR3 GPR42	1.69e-05	3	83	2	22673524
Pubmed	The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids.	FFAR3 GPR42	1.69e-05	3	83	2	12496283
Pubmed	Plasma Membrane Calcium ATPase-Neuroplastin Complexes Are Selectively Stabilized in GM1-Containing Lipid Rafts.	ATP2B1 ATP2B2	1.69e-05	3	83	2	34948386
Pubmed	Short-chain fatty acids activate GPR41 and GPR43 on intestinal epithelial cells to promote inflammatory responses in mice.	FFAR3 GPR42	1.69e-05	3	83	2	23665276
Pubmed	Microbial short-chain fatty acids modulate CD8+ T cell responses and improve adoptive immunotherapy for cancer.	FFAR3 GPR42	1.69e-05	3	83	2	34210970
Pubmed	Dietary short-chain fatty acid intake improves the hepatic metabolic condition via FFAR3.	FFAR3 GPR42	1.69e-05	3	83	2	31719611
Pubmed	Acetate and propionate short chain fatty acids stimulate adipogenesis via GPCR43.	FFAR3 GPR42	1.69e-05	3	83	2	16123168
Pubmed	GPR41 gene expression is mediated by internal ribosome entry site (IRES)-dependent translation of bicistronic mRNA encoding GPR40 and GPR41 proteins.	FFAR3 GPR42	1.69e-05	3	83	2	22493486
Pubmed	Extracellular ionic locks determine variation in constitutive activity and ligand potency between species orthologs of the free fatty acid receptors FFA2 and FFA3.	FFAR3 GPR42	1.69e-05	3	83	2	23066016
Pubmed	Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes.	FFAR3 GPR42	1.69e-05	3	83	2	25581519
Pubmed	Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2.	FFAR3 GPR42	1.69e-05	3	83	2	22190648
Pubmed	Trafficking of presynaptic PMCA signaling complexes in mouse photoreceptors requires Cav1.4 α1 subunits.	ATP2B1 ATP2B2	1.69e-05	3	83	2	22183401
Pubmed	Microbiota-Derived Short-Chain Fatty Acids Promote the Memory Potential of Antigen-Activated CD8+ T Cells.	FFAR3 GPR42	1.69e-05	3	83	2	31272808
Pubmed	GPR41/FFAR3 and GPR43/FFAR2 as cosensors for short-chain fatty acids in enteroendocrine cells vs FFAR3 in enteric neurons and FFAR2 in enteric leukocytes.	FFAR3 GPR42	1.69e-05	3	83	2	23885020
Pubmed	Dietary Fiber Confers Protection against Flu by Shaping Ly6c- Patrolling Monocyte Hematopoiesis and CD8+ T Cell Metabolism.	FFAR3 GPR42	1.69e-05	3	83	2	29768180
Pubmed	Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41.	FFAR3 GPR42	1.69e-05	3	83	2	18931303
Pubmed	Protein kinase C phosphorylates the carboxyl terminus of the plasma membrane Ca(2+)-ATPase from human erythrocytes.	ATP2B1 ATP2B2	1.69e-05	3	83	2	1827443
Pubmed	GPR41 and GPR43 regulate CD8+ T cell priming during herpes simplex virus type 1 infection.	FFAR3 GPR42	1.69e-05	3	83	2	38524121
Pubmed	Plasma membrane Ca2+ ATPase isoform 2b interacts preferentially with Na+/H+ exchanger regulatory factor 2 in apical plasma membranes.	ATP2B1 ATP2B2	1.69e-05	3	83	2	11786550
Pubmed	Abnormalities in microbiota/butyrate/FFAR3 signaling in aging gut impair brain function.	FFAR3 GPR42	1.69e-05	3	83	2	38329121
Pubmed	Inhibitory interaction of the 14-3-3 proteins with ubiquitous (PMCA1) and tissue-specific (PMCA3) isoforms of the plasma membrane Ca2+ pump.	ATP2B1 ATP2B3	3.37e-05	4	83	2	18029012
Pubmed	Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation.	FFAR3 GPR42	3.37e-05	4	83	2	23401498
Pubmed	A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1.	FFAR3 GPR42	3.37e-05	4	83	2	9344866
Pubmed	PSD95beta regulates plasma membrane Ca2+ pump localization at the photoreceptor synapse.	ATP2B1 ATP2B2	3.37e-05	4	83	2	19233278
Pubmed	Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41).	FFAR3 GPR42	3.37e-05	4	83	2	21518883
Pubmed	PRMT6 functionally associates with PRMT5 to promote colorectal cancer progression through epigenetically repressing the expression of CDKN2B and CCNG1.	PRMT6 CDKN2B	3.37e-05	4	83	2	36400182
Pubmed	A family of fatty acid binding receptors.	FFAR3 GPR42	3.37e-05	4	83	2	15684720
Pubmed	Loss of oriented cell division does not initiate cyst formation.	AGER PKD2	3.37e-05	4	83	2	19959710
Pubmed	Maternal High Fiber Diet during Pregnancy and Lactation Influences Regulatory T Cell Differentiation in Offspring in Mice.	FFAR3 GPR42	3.37e-05	4	83	2	29021375
Pubmed	Microbial metabolites, short-chain fatty acids, restrain tissue bacterial load, chronic inflammation, and associated cancer in the colon of mice.	FFAR3 GPR42	3.37e-05	4	83	2	29644622
Pubmed	Biology, structure and mechanism of P-type ATPases.	ATP2B1 ATP2B2 ATP2B3	4.58e-05	29	83	3	15071553
Pubmed	Fatty acid binding receptors and their physiological role in type 2 diabetes.	FFAR3 GPR42	5.60e-05	5	83	2	19009545
Pubmed	Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells.	FFAR3 GPR42	5.60e-05	5	83	2	24327954
Pubmed	T-type calcium channels functionally interact with spectrin (α/β) and ankyrin B.	SPTA1 CACNA1G	5.60e-05	5	83	2	29720258
Pubmed	Lactate inhibits lipolysis in fat cells through activation of an orphan G-protein-coupled receptor, GPR81.	FFAR3 GPR42	5.60e-05	5	83	2	19047060
Pubmed	Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.	SUGP2 UGGT1 NOL6 MEPCE SAE1 ATP2B1 ABHD12 B3GAT3 ZFPL1	7.93e-05	754	83	9	33060197
Pubmed	Characterization of PISP, a novel single-PDZ protein that binds to all plasma membrane Ca2+-ATPase b-splice variants.	ATP2B1 ATP2B2	8.39e-05	6	83	2	12763866
Pubmed	Three genes in the human MHC class III region near the junction with the class II: gene for receptor of advanced glycosylation end products, PBX2 homeobox gene and a notch homolog, human counterpart of mouse mammary tumor gene int-3.	AGER NOTCH4	8.39e-05	6	83	2	7835890
Pubmed	Free fatty acid receptors act as nutrient sensors to regulate energy homeostasis.	FFAR3 GPR42	8.39e-05	6	83	2	19460454
Pubmed	Tlag2, an N-methyl-N-nitrosourea susceptibility locus, maps to mouse chromosome 4.	CDKN2B TIE1	1.17e-04	7	83	2	11813303
Pubmed	Common variants in or near FGF5, CYP17A1 and MTHFR genes are associated with blood pressure and hypertension in Chinese Hans.	PLCD3 ATP2B1	1.17e-04	7	83	2	20852445
Pubmed	Vascular patterning defects associated with expression of activated Notch4 in embryonic endothelium.	TIE1 NOTCH4	1.17e-04	7	83	2	11344305
Pubmed	Vagal neuron expression of the microbiota-derived metabolite receptor, free fatty acid receptor (FFAR3), is necessary for normal feeding behavior.	FFAR3 GPR42	1.56e-04	8	83	2	34626852
Pubmed	Confirmation of the novel association at the BTNL2 locus with ulcerative colitis.	AGER NOTCH4	1.56e-04	8	83	2	19659809
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	PPP1R26 PRMT6 ZSWIM9 SPIRE2 SYNE3 TRAPPC12 DENND4B ABHD12	2.43e-04	689	83	8	36543142
Pubmed	Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease.	WDR35 ATP2B1	3.05e-04	11	83	2	22751097
Pubmed	A Hypoxia-Induced SCFFBXL1 E3 Ligase Ubiquitinates and Degrades the MEN1 Tumor Suppressor to Promote Colorectal Cancer Tumorigenesis.	NOL6 AMBRA1 ZFPL1	3.14e-04	55	83	3	34237211
Pubmed	Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death.	WDR35 AMBRA1 WDR41	3.32e-04	56	83	3	27103069
Pubmed	Strain-specific modifier genes governing craniofacial phenotypes.	TIE1 B3GALT6	3.66e-04	12	83	2	22371338
Pubmed	Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling.	INPP5E SPTA1 ATP2B1 ATP2B2	4.34e-04	147	83	4	16959763
Pubmed	Microbiota modulate sympathetic neurons via a gut-brain circuit.	FFAR3 GPR42	5.79e-04	15	83	2	32641826
Pubmed	Molecular detection of maturation stages in the developing kidney.	NPHS1 CDKN2B	7.48e-04	17	83	2	33197428
Pubmed	Cell cycle gene-specific control of transcription has a critical role in proliferation of primordial germ cells.	CDKN2B MEPCE	7.48e-04	17	83	2	23154982
Pubmed	DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.	GTF3C1 RECQL4 TONSL SAE1 ATP2B1 ABHD12	7.65e-04	453	83	6	29656893
Pubmed	Association of MHC SNP genotype with susceptibility to type 1 diabetes: a modified survival approach.	AGER NOTCH4	8.40e-04	18	83	2	19143821
Pubmed	New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.	TCAF1 GTF3C1 SUGP2 EXD2 ASPM B3GALT6	8.47e-04	462	83	6	31138677
Pubmed	FAM105A/OTULINL Is a Pseudodeubiquitinase of the OTU-Class that Localizes to the ER Membrane.	SYNE3 DENND4B UGGT1 WDR41 ABHD12 ZFPL1	9.06e-04	468	83	6	31056421
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	PLCD3 PHKA2 GTF3C1 RECQL4 NOL6 TONSL AMBRA1	9.38e-04	650	83	7	38777146
Pubmed	Deficiency of zonula occludens-1 causes embryonic lethal phenotype associated with defected yolk sac angiogenesis and apoptosis of embryonic cells.	TIE1 TJP3	1.15e-03	21	83	2	18353970
Pubmed	CECR2 is involved in spermatogenesis and forms a complex with SNF2H in the testis.	BAZ2A ASPM	1.15e-03	21	83	2	22154806
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PPP1R26 PLCD3 TCAF1 WDR35 RNF213 PDZRN4	1.18e-03	493	83	6	15368895
Pubmed	Klf2 is an essential regulator of vascular hemodynamic forces in vivo.	TIE1 NOTCH4	1.26e-03	22	83	2	17141159
Cytoband	11p15.5	ANO9 DRD4 LRRC56 PIDD1	6.83e-05	118	84	4	11p15.5
Cytoband	19q13.1	NPHS1 FFAR3 GPR42	1.45e-04	55	84	3	19q13.1
Cytoband	8q24.3	WDR97 RECQL4 TONSL	1.20e-03	113	84	3	8q24.3
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	NPHS1 SCAF1 ZSWIM9 FFAR3 GPR42 PLEKHA4 SAE1 IRGQ	1.54e-03	1192	84	8	chr19q13
GeneFamily	ATPases Ca2+ transporting	ATP2B1 ATP2B2 ATP2B3	2.88e-06	9	60	3	1209
GeneFamily	WD repeat domain containing	WDR97 WDR35 FBXW4 AMBRA1 WDR41 DCAF4L1	2.27e-04	262	60	6	362
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-Mes-Like\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PLCD3 NPHS1 LRRC14B AGER KSR2 ZFPL1	6.48e-08	110	84	6	c80d1c3df75648e2c8f6832279c2acca63d76681
ToppCell	tumor_Lymph_Node_/_Brain-Myeloid_cells-Pleural_Mac\|Myeloid_cells / Location, Cell class and cell subclass	ABHD18 INPP5E TONSL PIDD1 B3GALT6 B3GAT3	7.92e-07	168	84	6	8697b40b2ec2cce68ef3beb4792eb3eff29be053
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Inner_Medullary_Collecting_Duct_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PLCD3 SPIRE2 KSR2 B3GNT3 ALS2CL TJP3	1.77e-06	193	84	6	a5695ce2e24a62026ae28f3dea07ca4a435206b8
ToppCell	TCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_Tubular\|TCGA-Stomach / Sample_Type by Project: Shred V9	RECQL4 NOL6 TONSL ASPM PPM1H	6.41e-06	138	84	5	93497c0a5d5e54006653b2dedc7a7041e1a613e6
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-Mes-Like-AT1_Progenitor\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PLCD3 NPHS1 AGER KSR2 ZFPL1	1.20e-05	157	84	5	a93866f051472506f1468f379c0d5313e02c9731
ToppCell	facs-Lung-Endomucin-3m-Lymphocytic-CD4+_T\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABHD18 APBB3 AMBRA1 BCKDHB PPM1H	1.31e-05	160	84	5	5c68d6a76c59e3a7e668ae5471396478a55756ac
ToppCell	facs-Lung-Endomucin-3m-Lymphocytic-CD4-positive,_alpha-beta_T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABHD18 APBB3 AMBRA1 BCKDHB PPM1H	1.31e-05	160	84	5	0fee84844733d36805e1df90ca09478169746708
ToppCell	normal_Lung-B_lymphocytes-Undetermined\|B_lymphocytes / Location, Cell class and cell subclass	ATG9B TIE1 FFAR3 GPR42 PLEKHA4	1.81e-05	171	84	5	f49dfe11ae66d82125b577c48345a13683d7bb7b
ToppCell	droplet-Lung-3m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PLCD3 TIE1 B3GNT3 ATP2B2 NOTCH4	2.93e-05	189	84	5	2e43428f1ef9683c6f8c9897d46aa7d34bf9047f
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-Epcam____podocyte\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CAPN13 CDKN2B BOK AGER CACNA1G	2.93e-05	189	84	5	319e42f6e2322208de78bc666fb2c074707eb4da
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-podocyte\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CAPN13 CDKN2B BOK AGER CACNA1G	3.00e-05	190	84	5	050d6e0546954675b6adbfecb67854b1e09739d1
ToppCell	PBMC-Severe-Myeloid-Neutrophil-Neutrophil-Neu_4\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	RECQL4 PKD2 ASPM MEPCE PIDD1	3.00e-05	190	84	5	3f0c7d130f66faea778fe567604edf1b4cdf85b3
ToppCell	PBMC-Severe-Myeloid-Neutrophil-Neutrophil-Neu_4\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	RECQL4 PKD2 ASPM MEPCE PIDD1	3.16e-05	192	84	5	c09dcc73ff9c3855a0f3d7bfa0d5c99c09a117f2
ToppCell	control-unassigned\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	PRMT6 AGER MEPCE ALS2CL NOTCH4	3.74e-05	199	84	5	50e2da35edff1aadef939cfbd4549f73c1a07717
ToppCell	Parenchymal-10x5prime-Stromal-Peri/Epineurial_\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	TRIL PLEKHA4 GPR135 DCAF4L1 PDZRN4	3.83e-05	200	84	5	4c3c11dd5e71ebc3d62264eeaeb71a850b149779
Drug	1sqc	ATP2B1 ATP2B2 ATP2B3	5.31e-06	10	82	3	CID000444279
Drug	2,5-dimethylquinone	ATP2B1 ATP2B2 ATP2B3	7.28e-06	11	82	3	CID000008718
Drug	1vyq	ATP2B1 ATP2B2 ATP2B3	9.68e-06	12	82	3	CID004369390
Drug	Ro 46861	ATP2B1 ATP2B2 ATP2B3	9.68e-06	12	82	3	CID000003128
Drug	8-hydroxycoumarin	ATP2B1 ATP2B2 ATP2B3	1.25e-05	13	82	3	CID000122783
Drug	p-hydroxyhippuric acid	ATP2B1 ATP2B2 ATP2B3	1.59e-05	14	82	3	CID000151012
Drug	AC1L88YH	ATP2B1 ATP2B2 ATP2B3	2.95e-05	17	82	3	CID000374551
Disease	Hailey-Hailey disease (implicated_via_orthology)	ATP2B1 ATP2B2 ATP2B3	4.11e-07	6	82	3	DOID:0050429 (implicated_via_orthology)
Disease	migraine disorder	KSR2 RNF213 AMBRA1 ATP2B1 NOTCH4 PDZRN4	4.86e-04	357	82	6	MONDO_0005277
Disease	response to irinotecan	TRIL SYNE3	7.82e-04	15	82	2	EFO_0004829
Disease	alkaline phosphatase measurement	PRMT6 MPV17L2 INPP5E RECQL4 TONSL PKD2 FBXW4 ABHD12 PDZRN4	2.02e-03	1015	82	9	EFO_0004533
Disease	hypertension, COVID-19	ICAM5 ATP2B1	2.56e-03	27	82	2	EFO_0000537, MONDO_0100096
Disease	neuroblastoma, cutaneous melanoma	SPIRE2 NOL6	2.75e-03	28	82	2	EFO_0000389, EFO_0000621

Protein segments in the cluster

Peptide	Gene	Start	Entry
WRGQRKALRQLLSGV	ALS2CL	126	Q60I27
RGVEQRNKALDWLRG	B3GAT3	156	O94766
RAWRRRAALGLGTLA	B3GALT6	6	Q96L58
RREVRIKKGSHRWQG	BAZ2A	561	Q9UIF9
RRLLLTKLFIRGWGR	ABHD18	11	Q0P651
RWVFKRRLGLLGRTL	CLDN25	111	C9JDP6
GRLDQEEFARLWKRL	CAPN13	556	Q6MZZ7
EKNAVRILWGRERGA	AMBRA1	6	Q9C0C7
QRLREKMWHGRQRLG	ANO9	741	A1A5B4
FVRKTLATWLRRRGG	BOK	156	Q9UMX3
RGWLVRKRFLEQRAK	ASPM	3091	Q8IZT6
AERELRRGQILWFRG	ATP2B1	1096	P20020
RELRRGQILWFRGLN	ATP2B2	1121	Q01814
ELRRGQILWFRGLNR	ATP2B3	1096	Q16720
AGLLDKVGRSRELRW	C17orf113	611	A0A1B0GUU1
LLIGVILWQRRQRRG	AGER	356	Q15109
GPRVLAWRRREKALL	PDZRN4	161	Q6ZMN7
PWKELRVAGRLRRVA	SLC34A3	56	Q8N130
ALGRRKGVWLRLRKI	ABHD12	61	Q8N2K0
LLRLRAAGAEGHWRR	BCKDHB	11	P21953
VGGVLWQRRLRRLAE	NPHS1	1081	O60500
QVRLRPRVWRDKAGG	EFCAB2	6	Q5VUJ9
MARGGWRRLRRLLSA	MPV17L2	1	Q567V2
DGRLRVLKPEWFRGR	MEPCE	431	Q7L2J0
LDDKGWRRRRFRGSQ	INPP5E	86	Q9NRR6
ADGRRPVRLLWKKAR	IL31RA	241	Q8NI17
RREGLIRARLQGWKA	GALNT9	221	Q9HCQ5
GRREDKLRIQNGWLC	KSR2	816	Q6VAB6
IDLRCRNRGKGWRAT	DCAF4L1	251	Q3SXM0
GFVLWKGIQRRRRSK	EXD2	21	Q9NVH0
LRRNGTQRGLRWLAR	ICAM5	71	Q9UMF0
RLAKRWVRAQLLGEG	NOL6	856	Q9H6R4
GRALGRWGRTQLLAR	LRRC14B	126	A6NHZ5
RLVWILGRGGSHRRQ	GPR42	206	O15529
FRGLQRWEVARRAKL	DRD4	216	P21917
RGKAWGAQARARLRL	APBB3	421	O95704
IGRRRALQLLAGAWL	GPR135	221	Q8IZ08
SKGERVRAWIRARLP	CACNA1G	1231	O43497
GRKLWRRRRGDAVVG	GHSR	236	Q92847
TWRRGLRLQKRRNAL	PIK3CD-AS1	41	Q5SR53
RLVWILGRGGSHRRQ	FFAR3	206	O14843
RAGARLDVRDAWGRL	CDKN2B	101	P42772
RLGILRNWAALRGKT	PRMT6	71	Q96LA8
LGARGWSRLARLQLR	ATG9B	476	Q674R7
LRRTWGRERKVRGLQ	B3GNT3	126	Q9Y2A9
QNWRLGRCREGILLK	FBXW4	101	P57775
RLRWAKLRNVVLGAA	DENND4B	871	O75064
VALLRGQLAEWRRGL	IRGQ	506	Q8WZA9
GERQGQWLRRRRLDG	PHKA2	1061	P46019
GGLARKAWERLRLHR	PIDD1	601	Q9HB75
ARGVLRNYWERLLRK	MRPL32	16	Q9BYC8
KGINLERRLGSRWFA	RHBDD1	91	Q8TEB9
ERLRGLLRSRGAWEQ	SYNE3	321	Q6ZMZ3
LLNAVRWLDGGRRGK	TCAF1	286	Q9Y4C2
RCWRRRLAPNKDKGI	FER1L5	1001	A0AVI2
DLQSRGRRLRVLGSW	LRRC56	471	Q8IYG6
LRGWLRALGRASRAE	PLEKHA4	141	Q9H4M7
GRALRSRLLRKQAWK	RECQL4	366	O94761
RQIRLWGLEAQKRLR	SAE1	21	Q9UBE0
FLEQLGGLRRDWKDR	PPP1R26	731	Q5T8A7
LTLRVGLWVRKDRDG	NOTCH4	1321	Q99466
DLLAQARRWKGLERV	RNF213	4486	Q63HN8
RALQIRDWRGGRLEN	ZSWIM9	516	Q86XI8
EGRQASIRLWRSRLG	TRAPPC12	531	Q8WVT3
VLKDRGWRISNDRLG	PPM1H	481	Q9ULR3
RGWKGNELQRCIRKR	MRPL51	81	Q4U2R6
QRWVRGLTKLRARLD	PLCD3	161	Q8N3E9
RWGGLDLRRKILTQR	SCAF1	476	Q9H7N4
LLRLWDGTRGQERRE	TIE1	581	P35590
KQERRLRPVRGEGWA	SPIRE2	351	Q8WWL2
QGHLGRRKGSKWNRR	TONSL	511	Q96HA7
WGQDKLSRRVGRLLA	WDR97	376	A6NE52
WLRRKLRARRKGGAP	TRIL	721	Q7L0X0
GLLRAQGLRGWKARR	SUGP2	681	Q8IX01
WERLRGLALQRQKAL	SPTA1	246	P02549
RVAWAERLVRGLRGL	PKD2	186	Q13563
ERLVRGLRGLWGTRL	PKD2	191	Q13563
RAEFWRLRGLRRGAK	TJP3	571	O95049
LERLGRSRWQGELQR	GTF3C1	181	Q12789
RRDLAIGLRLKLGDW	WDR35	766	Q9P2L0
RQRWKLRGRIEGSGK	RIPOR1	236	Q6ZS17
WKNGERESGLRSLRL	WDR41	431	Q9HAD4
LGWLARLLRSRAGSR	ZFPL1	241	O95159
GAWILRLRKGRSEDI	UGGT1	1161	Q9NYU2
RGKRAAGLLLRRNPW	nan	31	Q6ZTC4
LRGGKLLREDLWVRG	AMDHD2	21	Q9Y303