Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	olfactory receptor activity	OR12D3 OR2A25 OR8B12 OR8J3 OR2M5 OR8J1 OR2M7 OR14C36 OR5M11 OR2T6 OR2M2 OR6C6 OR8B2 OR10H3 OR4K3 OR5G3 OR2AP1 OR51M1 OR6C4 OR6C70 OR2AJ1 OR8B3	1.04e-26	431	40	22	GO:0004984
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR12D3 OR2A25 OR8B12 OR8J3 OR2M5 OR8J1 OR2M7 OR14C36 OR5M11 OR2T6 OR2M2 OR6C6 OR8B2 OR10H3 OR4K3 OR5G3 OR2AP1 OR51M1 OR6C4 OR6C70 OR2AJ1 OR8B3	6.76e-20	884	40	22	GO:0004930
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	OR12D3 IL12RB2 OR2A25 OR8B12 OR8J3 OR2M5 OR8J1 GRIN2A OR2M7 OR14C36 OR5M11 OR2T6 OR2M2 OR6C6 OR8B2 OR10H3 OR4K3 OR5G3 OR2AP1 OR51M1 OR6C4 OR6C70 OR2AJ1 OR8B3	1.58e-18	1353	40	24	GO:0004888
GeneOntologyMolecularFunction	odorant binding	OR12D3 OR2A25 OR8B12 OR8J3 OR8J1 OR14C36 OR5M11 OR8B2 OR5G3 OR8B3	5.45e-14	127	40	10	GO:0005549
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of smell	OR12D3 OR2A25 OR8B12 OR8J3 OR2M5 OR8J1 OR2M7 OR14C36 OR5M11 OR2T6 OR2M2 OR6C6 OR8B2 OR10H3 OR4K3 OR5G3 OR2AP1 OR51M1 OR6C4 OR6C70 OR2AJ1 OR8B3	5.45e-27	432	40	22	GO:0050911
GeneOntologyBiologicalProcess	sensory perception of smell	OR12D3 OR2A25 OR8B12 OR8J3 OR2M5 OR8J1 OR2M7 OR14C36 OR5M11 OR2T6 OR2M2 OR6C6 OR8B2 OR10H3 OR4K3 OR5G3 OR2AP1 OR51M1 OR6C4 OR6C70 OR2AJ1 OR8B3	2.78e-26	465	40	22	GO:0007608
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception	OR12D3 OR2A25 OR8B12 OR8J3 OR2M5 OR8J1 OR2M7 OR14C36 OR5M11 OR2T6 OR2M2 OR6C6 OR8B2 OR10H3 OR4K3 OR5G3 OR2AP1 OR51M1 OR6C4 OR6C70 OR2AJ1 OR8B3	7.06e-26	485	40	22	GO:0050907
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	OR12D3 OR2A25 OR8B12 OR8J3 OR2M5 OR8J1 GRIN2A OR2M7 OR14C36 OR5M11 OR2T6 OR2M2 OR6C6 OR8B2 OR10H3 OR4K3 OR5G3 OR2AP1 OR51M1 OR6C4 OR6C70 OR2AJ1 OR8B3	8.50e-26	582	40	23	GO:0050906
GeneOntologyBiologicalProcess	detection of stimulus	OR12D3 OR2A25 OR8B12 OR8J3 OR2M5 OR8J1 GRIN2A OR2M7 OR14C36 OR5M11 OR2T6 OR2M2 OR6C6 OR8B2 OR10H3 OR4K3 OR5G3 OR2AP1 OR51M1 OR6C4 OR6C70 FOXF1 OR2AJ1 OR8B3	2.92e-25	722	40	24	GO:0051606
GeneOntologyBiologicalProcess	detection of chemical stimulus	OR12D3 OR2A25 OR8B12 OR8J3 OR2M5 OR8J1 OR2M7 OR14C36 OR5M11 OR2T6 OR2M2 OR6C6 OR8B2 OR10H3 OR4K3 OR5G3 OR2AP1 OR51M1 OR6C4 OR6C70 OR2AJ1 OR8B3	3.88e-25	524	40	22	GO:0009593
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	OR12D3 OR2A25 OR8B12 OR8J3 OR2M5 OR8J1 OR2M7 OR14C36 OR5M11 OR2T6 OR2M2 OR6C6 OR8B2 OR10H3 OR4K3 OR5G3 OR2AP1 OR51M1 OR6C4 OR6C70 OR2AJ1 OR8B3	9.98e-25	547	40	22	GO:0007606
GeneOntologyBiologicalProcess	sensory perception	OR12D3 OR2A25 OR8B12 OR8J3 OR2M5 OR8J1 GRIN2A OR2M7 OR14C36 OR5M11 OR2T6 OR2M2 OR6C6 OR8B2 OR10H3 OR4K3 OR5G3 OR2AP1 OR51M1 OR6C4 OR6C70 OR2AJ1 OR8B3	8.79e-20	1072	40	23	GO:0007600
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	OR12D3 OR2A25 OR8B12 OR8J3 OR2M5 OR8J1 OR2M7 OR14C36 OR5M11 OR2T6 OR2M2 OR6C6 OR8B2 OR10H3 OR4K3 OR5G3 OR2AP1 OR51M1 OR6C4 OR6C70 OR2AJ1 OR8B3 PLCE1	3.03e-17	1395	40	23	GO:0007186
GeneOntologyCellularComponent	endoplasmic reticulum membrane	OR2A25 OR2M5 GRIN2A OR2M7 NRROS OR2M2 TMBIM6 OR51M1 GGCX	6.15e-04	1293	40	9	GO:0005789
GeneOntologyCellularComponent	endoplasmic reticulum subcompartment	OR2A25 OR2M5 GRIN2A OR2M7 NRROS OR2M2 TMBIM6 OR51M1 GGCX	6.36e-04	1299	40	9	GO:0098827
GeneOntologyCellularComponent	nuclear outer membrane-endoplasmic reticulum membrane network	OR2A25 OR2M5 GRIN2A OR2M7 NRROS OR2M2 TMBIM6 OR51M1 GGCX	7.42e-04	1327	40	9	GO:0042175
Domain	Olfact_rcpt	OR12D3 OR2A25 OR8B12 OR8J3 OR2M5 OR8J1 OR2M7 OR14C36 OR5M11 OR2T6 OR2M2 OR6C6 OR8B2 OR10H3 OR2AP1 OR51M1 OR6C4 OR6C70 OR2AJ1 OR8B3	4.25e-24	393	38	20	IPR000725
Domain	7tm_1	OR12D3 OR2A25 OR8B12 OR8J3 OR2M5 OR8J1 OR2M7 OR14C36 OR5M11 OR2T6 OR2M2 OR6C6 OR8B2 OR10H3 OR2AP1 OR51M1 OR6C4 OR6C70 OR2AJ1 OR8B3	2.12e-19	677	38	20	PF00001
Domain	G_PROTEIN_RECEP_F1_1	OR12D3 OR2A25 OR8B12 OR8J3 OR2M5 OR8J1 OR2M7 OR14C36 OR5M11 OR2T6 OR2M2 OR6C6 OR8B2 OR10H3 OR2AP1 OR51M1 OR6C4 OR6C70 OR2AJ1 OR8B3	2.67e-19	685	38	20	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR12D3 OR2A25 OR8B12 OR8J3 OR2M5 OR8J1 OR2M7 OR14C36 OR5M11 OR2T6 OR2M2 OR6C6 OR8B2 OR10H3 OR2AP1 OR51M1 OR6C4 OR6C70 OR2AJ1 OR8B3	3.17e-19	691	38	20	PS50262
Domain	GPCR_Rhodpsn	OR12D3 OR2A25 OR8B12 OR8J3 OR2M5 OR8J1 OR2M7 OR14C36 OR5M11 OR2T6 OR2M2 OR6C6 OR8B2 OR10H3 OR2AP1 OR51M1 OR6C4 OR6C70 OR2AJ1 OR8B3	3.26e-19	692	38	20	IPR000276
Domain	GPCR_Rhodpsn_7TM	OR12D3 OR2A25 OR8B12 OR8J3 OR2M5 OR8J1 OR2M7 OR14C36 OR5M11 OR2T6 OR2M2 OR6C6 OR8B2 OR10H3 OR2AP1 OR51M1 OR6C4 OR6C70 OR8B3	5.05e-18	670	38	19	IPR017452
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR12D3 OR2A25 OR8B12 OR8J3 OR2M5 OR8J1 OR2M7 OR14C36 OR5M11 OR2T6 OR2M2 OR6C6 OR8B2 OR10H3 OR4K3 OR5G3 OR2AP1 OR51M1 OR6C4 OR6C70 OR2AJ1 OR8B3	1.38e-25	417	35	22	M4072
Pathway	REACTOME_SENSORY_PERCEPTION	OR12D3 OR2A25 OR8B12 OR8J3 OR2M5 OR8J1 OR2M7 OR14C36 OR5M11 OR2T6 OR2M2 OR6C6 OR8B2 OR10H3 OR4K3 OR5G3 OR2AP1 OR51M1 OR6C4 OR6C70 OR2AJ1 OR8B3	1.48e-21	636	35	22	M41834
Pathway	KEGG_OLFACTORY_TRANSDUCTION	OR12D3 OR2A25 OR8B12 OR8J3 OR2M5 OR8J1 OR2M7 OR14C36 OR5M11 OR2T6 OR2M2 OR6C6 OR10H3 OR51M1 OR6C4 OR6C70	2.10e-16	389	35	16	M14091
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR12D3 OR2A25 OR8B12 OR8J3 OR2M5 OR8J1 OR2M7 OR14C36 OR5M11 OR2T6 OR2M2 OR6C6 OR8B2 OR10H3 OR5G3 OR2AP1 OR51M1 OR6C70 OR2AJ1 OR8B3	4.18e-30	340	40	20	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR12D3 OR2A25 OR8B12 OR8J3 OR2M5 OR8J1 OR2M7 OR14C36 OR5M11 OR2T6 OR2M2 OR6C6 OR8B2 OR10H3 OR5G3 OR2AP1 OR51M1 OR6C70 OR2AJ1 OR8B3	4.18e-30	340	40	20	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR12D3 OR2A25 OR8B12 OR8J3 OR2M5 OR8J1 OR2M7 OR14C36 OR5M11 OR2T6 OR2M2 OR6C6 OR8B2 OR10H3 OR5G3 OR2AP1 OR51M1 OR6C70 OR2AJ1 OR8B3	5.00e-30	343	40	20	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR12D3 OR2A25 OR8B12 OR8J3 OR2M5 OR8J1 OR2M7 OR14C36 OR5M11 OR2T6 OR2M2 OR6C6 OR8B2 OR10H3 OR5G3 OR2AP1 OR51M1 OR6C70 OR2AJ1 OR8B3	5.97e-30	346	40	20	14611657
Pubmed	The human olfactory receptor gene family.	OR12D3 OR8B12 OR8J3 OR2M5 OR8J1 OR2M7 OR14C36 OR5M11 OR8B2 OR10H3 OR4K3 OR5G3 OR2AP1 OR51M1 OR6C4 OR2AJ1 OR8B3	9.08e-21	541	40	17	14983052
Pubmed	DEFOG: a practical scheme for deciphering families of genes.	OR8B12 OR8J3 OR8J1 OR5M11 OR2T6 OR2M2 OR8B2 OR4K3	1.41e-10	219	40	8	12213199
Pubmed	Odorant and vomeronasal receptor genes in two mouse genome assemblies.	OR8J3 OR8J1 OR14C36 OR5M11 OR6C70 OR2AJ1	2.73e-10	74	40	6	15081110
Pubmed	High-throughput microarray detection of olfactory receptor gene expression in the mouse.	OR2M5 OR2M7 OR2M2	5.63e-09	4	40	3	15377787
Pubmed	Variants in the 1q21 risk region are associated with a visual endophenotype of autism and schizophrenia.	OR6C6 OR6C4 OR6C70	2.80e-06	24	40	3	24152035
Pubmed	Reelin signaling facilitates maturation of CA1 glutamatergic synapses.	RELN GRIN2A	1.29e-05	5	40	2	17229826
Pubmed	Modified N-methyl-D-aspartate receptor subunit expression emerges in reeler Purkinje cells after accomplishment of the adult wild-type expression.	RELN GRIN2A	1.29e-05	5	40	2	9004271
Pubmed	Reelin deficiency causes specific defects in the molecular composition of the synapses in the adult brain.	RELN GRIN2A	2.70e-05	7	40	2	21664258
Pubmed	Expression analysis of an evolutionarily conserved metallophosphodiesterase gene, Mpped1, in the normal and beta-catenin-deficient malformed dorsal telencephalon.	RELN MPPED1	2.70e-05	7	40	2	20503375
Pubmed	NMDA-receptor proteins are upregulated in the hippocampus of postnatal heterozygous reeler mice.	RELN GRIN2A	2.70e-05	7	40	2	16438943
Pubmed	Different noses for different people.	OR4K3 OR5G3	3.60e-05	8	40	2	12730696
Pubmed	BDNF regulates spontaneous correlated activity at early developmental stages by increasing synaptogenesis and expression of the K+/Cl- co-transporter KCC2.	RELN GRIN2A	1.95e-04	18	40	2	12588844
Pubmed	Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.	RELN GRIN2A GLS	3.43e-04	118	40	3	19156168
Pubmed	Gamma protocadherins are required for survival of spinal interneurons.	RELN GRIN2A	4.12e-04	26	40	2	12467588
Pubmed	Modulation of the combinatorial code of odorant receptor response patterns in odorant mixtures.	OR14C36 OR2AJ1	4.45e-04	27	40	2	32061665
Pubmed	Aurora kinase A regulates Survivin stability through targeting FBXL7 in gastric cancer drug resistance and prognosis.	CTCFL FOXF1	8.83e-04	38	40	2	28218735
Cytoband	1q44	OR2M5 OR2M7 OR14C36 OR2T6 OR2M2 OR2AJ1	5.92e-10	110	40	6	1q44
Cytoband	Ensembl 112 genes in cytogenetic band chr1q44	OR2M5 OR2M7 OR14C36 OR2T6 OR2M2 OR2AJ1	1.48e-09	128	40	6	chr1q44
Cytoband	12q13.2	OR6C6 OR2AP1 OR6C4 OR6C70	1.63e-07	55	40	4	12q13.2
Cytoband	11q12.1	OR8J3 OR8J1 OR5M11 OR5G3	1.21e-05	161	40	4	11q12.1
Cytoband	Ensembl 112 genes in cytogenetic band chr12q13	OR6C6 TMBIM6 OR2AP1 OR6C4 OR6C70	3.27e-05	423	40	5	chr12q13
Cytoband	Ensembl 112 genes in cytogenetic band chr11q12	OR8J3 OR8J1 OR5M11 OR5G3	2.31e-04	345	40	4	chr11q12
Cytoband	Ensembl 112 genes in cytogenetic band chr11q24	OR8B12 OR8B2 OR8B3	6.25e-04	191	40	3	chr11q24
Cytoband	11q24.2	OR8B12 OR8B3	1.40e-03	63	40	2	11q24.2
GeneFamily	Olfactory receptors, family 2	OR2A25 OR2M5 OR2M7 OR2T6 OR2M2 OR2AP1 OR2AJ1	1.44e-09	113	34	7	149
GeneFamily	Olfactory receptors, family 8	OR8B12 OR8J3 OR8J1 OR8B2 OR8B3	3.11e-08	49	34	5	155
GeneFamily	Olfactory receptors, family 6	OR6C6 OR6C4 OR6C70	1.19e-04	51	34	3	153
GeneFamily	Olfactory receptors, family 5	OR5M11 OR5G3	1.88e-02	112	34	2	152
Disease	sensory perception of smell	OR2M7 OR14C36 OR6C70	4.15e-06	29	32	3	GO_0007608
Disease	systemic scleroderma, rheumatoid arthritis, myositis, systemic lupus erythematosus	IL12RB2 GLS	7.82e-04	38	32	2	EFO_0000685, EFO_0000717, EFO_0000783, MONDO_0007915
Disease	response to hydrochlorothiazide, triglyceride measurement	THSD4 GRIN2A	1.19e-03	47	32	2	EFO_0004530, EFO_0005202
Disease	response to tenofovir	RELN GRIN2A	1.41e-03	51	32	2	EFO_0009279
Disease	Manic Disorder	RELN GRIN2A	2.70e-03	71	32	2	C0024713
Disease	Manic	RELN GRIN2A	3.25e-03	78	32	2	C0338831
Disease	Depression, Bipolar	RELN GRIN2A	3.33e-03	79	32	2	C0005587
Disease	otosclerosis	RELN CCSER1	3.50e-03	81	32	2	EFO_0004213
Disease	sudden cardiac arrest	GRIN2A PLCE1	3.67e-03	83	32	2	EFO_0004278
Disease	S-warfarin to R-warfarin ratio measurement	ARFGEF3 PLCE1	4.78e-03	95	32	2	EFO_0803331
Disease	glutamine measurement	CTCFL GLS	4.97e-03	97	32	2	EFO_0009768
Disease	status epilepticus (biomarker_via_orthology)	RELN GRIN2A	5.28e-03	100	32	2	DOID:1824 (biomarker_via_orthology)
Disease	cortical thickness	THSD4 RELN ZNF318 GLS PLCE1	6.53e-03	1113	32	5	EFO_0004840
Disease	bitter alcoholic beverage consumption measurement	RELN CCSER1	9.15e-03	133	32	2	EFO_0010092

Protein segments in the cluster

Peptide	Gene	Start	Entry
TFHCDVCMFTSSRMS	CTCFL	256	Q8NI51
VCMFTSSRMSSFNRH	CTCFL	261	Q8NI51
MDAFSKSGSMASHCD	CCSER1	271	Q9C0I3
TLSLMHSCGMYDFSG	GLS	456	O94925
SHMIVVSITYGSCMF	OR6C70	241	A6NIJ9
AFSTCGSHMMAVTLF	OR5M11	236	Q96RB7
MAHTFRGCSLAFMFI	IL12RB2	1	Q99665
VTTCDSSLHMPMYFF	OR14C36	46	Q8NHC7
KAFTTCSSHLMVVGM	OR2M2	236	Q96R28
KAFTTCSSHLMVVGM	OR2M5	236	A3KFT3
KAFTTCSSHLMVVGM	OR2M7	236	Q8NG81
CSSHMMVVTLFYGAA	OR2T6	241	Q8NHC8
IQMFCIHSFSFMESS	OR51M1	111	Q9H341
AISFEGCMTQMFFLH	OR4K3	91	Q96R72
CAVAATLVSHMMLAF	MFSD1	336	Q9H3U5
SHMIVISLSYGSCMF	OR2AP1	241	Q8NGE2
MSHQVCSMLTFAAYI	OR8B3	136	Q8NGG8
CGLGMAFSQSHVMAA	MPPED1	21	O15442
CASHMIAVTVFYGTM	OR8J3	241	Q8NGG0
SHMIVISLSYGSCMF	OR6C4	241	Q8NGE1
FEMSMGCSKPFSNSH	RELN	1666	P78509
TMMVFHLTFCGSNVI	OR10H3	161	O60404
MHSVMTAHLSFCGSQ	OR12D3	156	Q9UGF7
MAHTGSIMNLTFCAD	OR8B12	156	Q8NGG6
KAFSTCASHMMAVTI	OR8J1	236	Q8NGP2
CASHMMAVTIFYGTL	OR8J1	241	Q8NGP2
QNFASTFCSGMMHSP	ARFGEF3	701	Q5TH69
TAFMGTAMIFTCFTL	TMBIM6	116	P55061
MGLHSSFMALDFSGF	NRROS	521	Q86YC3
CMTQMFLFLSFAHTE	OR2A25	96	A4D2G3
KSFSTCSFHMIVVTM	OR2AJ1	236	Q8NGZ0
MALISTMTHTIFTFC	OR5G3	151	P0C626
MSHQVCSMLTFAAYI	OR8B2	136	Q96RD0
FSFNAMASSSMHSAG	FOXF1	346	Q12946
SISMCHQGLMSFEGF	PLCE1	1356	Q9P212
THAFFKAMLFMCSGS	MT-ND5	331	P03915
FSTCTSHMIVVSMTY	OR6C6	236	A6NF89
SHMIVVSMTYGSCIF	OR6C6	241	A6NF89
FHCMNSQLFSIGMFS	GGCX	286	P38435
TFIMASYMNHCTTTV	PLEKHH1	1316	Q9ULM0
MVSHFMGSLSVLCFL	THSD4	1	Q6ZMP0
CNTICGTMFDFFTHM	ZNF318	1071	Q5VUA4
FISHMGTSTMCGHYV	USP5	806	P45974
SCLSNMPTYSGHFTM	GRIN2A	1216	Q12879