Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionATP:ADP antiporter activity

SLC25A4 SLC25A5 SLC25A6

5.06e-075753GO:0005471
GeneOntologyMolecularFunctionADP transmembrane transporter activity

SLC25A4 SLC25A5 SLC25A6

8.22e-0611753GO:0015217
GeneOntologyMolecularFunctionATP transmembrane transporter activity

SLC25A4 SLC25A5 SLC25A6

1.80e-0514753GO:0005347
GeneOntologyMolecularFunctioncarbohydrate derivative transmembrane transporter activity

ABCC3 SLC25A4 SLC25A5 SLC25A6

7.14e-0559754GO:1901505
GeneOntologyMolecularFunctionpurine ribonucleotide transmembrane transporter activity

SLC25A4 SLC25A5 SLC25A6

8.54e-0523753GO:0005346
GeneOntologyMolecularFunctionadenine nucleotide transmembrane transporter activity

SLC25A4 SLC25A5 SLC25A6

1.24e-0426753GO:0000295
GeneOntologyMolecularFunctionoxidative phosphorylation uncoupler activity

SLC25A4 SLC25A5

1.38e-045752GO:0017077
GeneOntologyMolecularFunctionadenine transmembrane transporter activity

SLC25A4 SLC25A5

1.38e-045752GO:0015207
GeneOntologyMolecularFunctionpurine nucleotide transmembrane transporter activity

SLC25A4 SLC25A5 SLC25A6

1.73e-0429753GO:0015216
GeneOntologyMolecularFunctionnucleotide transmembrane transporter activity

SLC25A4 SLC25A5 SLC25A6

2.56e-0433753GO:0015215
GeneOntologyMolecularFunctiondynein intermediate chain binding

DNAH12 FRRS1L DNAH2

3.61e-0437753GO:0045505
GeneOntologyMolecularFunctioninositol-polyphosphate 5-phosphatase activity

INPP5B INPPL1

3.84e-048752GO:0004445
GeneOntologyMolecularFunctionorganophosphate ester transmembrane transporter activity

SLC25A4 SLC25A5 SLC25A6

4.22e-0439753GO:0015605
GeneOntologyMolecularFunctionpurine nucleobase transmembrane transporter activity

SLC25A4 SLC25A5

6.14e-0410752GO:0005345
GeneOntologyMolecularFunctionnucleobase transmembrane transporter activity

SLC25A4 SLC25A5

7.49e-0411752GO:0015205
GeneOntologyMolecularFunctionphosphatidylinositol phosphate 5-phosphatase activity

INPP5B INPPL1

1.06e-0313752GO:0034595
GeneOntologyMolecularFunctioninositol trisphosphate phosphatase activity

INPP5B INPPL1

1.23e-0314752GO:0046030
GeneOntologyMolecularFunctionnucleobase-containing compound transmembrane transporter activity

SLC25A4 SLC25A5 SLC25A6

1.42e-0359753GO:0015932
GeneOntologyMolecularFunctionminus-end-directed microtubule motor activity

DNAH12 DNAH2

2.05e-0318752GO:0008569
GeneOntologyMolecularFunctionSUMO binding

HABP4 HERC2

2.28e-0319752GO:0032183
GeneOntologyMolecularFunctioninositol phosphate phosphatase activity

INPP5B INPPL1

2.53e-0320752GO:0052745
GeneOntologyMolecularFunctionthreonine-type peptidase activity

GGTLC1 PSMB5

2.53e-0320752GO:0070003
GeneOntologyBiologicalProcessmitochondrial ADP transmembrane transport

SLC25A4 SLC25A5 SLC25A6

4.23e-075733GO:0140021
GeneOntologyBiologicalProcessmitochondrial ATP transmembrane transport

SLC25A4 SLC25A5 SLC25A6

2.35e-068733GO:1990544
GeneOntologyBiologicalProcessnuclear-transcribed mRNA poly(A) tail shortening

TNRC6A TNRC6B TNKS1BP1 TNRC6C

5.47e-0633734GO:0000289
GeneOntologyBiologicalProcessADP transport

SLC25A4 SLC25A5 SLC25A6

9.15e-0612733GO:0015866
GeneOntologyBiologicalProcesspositive regulation of nuclear-transcribed mRNA poly(A) tail shortening

TNRC6A TNRC6B TNRC6C

1.51e-0514733GO:0060213
GeneOntologyBiologicalProcessnegative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

SLC25A4 SLC25A5 SLC25A6

1.88e-0515733GO:1901029
GeneOntologyBiologicalProcessregulation of nuclear-transcribed mRNA poly(A) tail shortening

TNRC6A TNRC6B TNRC6C

2.30e-0516733GO:0060211
GeneOntologyBiologicalProcessnegative regulation of mitochondrial membrane permeability

SLC25A4 SLC25A5 SLC25A6

7.16e-0523733GO:0035795
GeneOntologyBiologicalProcessATP transport

SLC25A4 SLC25A5 SLC25A6

7.16e-0523733GO:0015867
GeneOntologyBiologicalProcessregulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

SLC25A4 SLC25A5 SLC25A6

8.16e-0524733GO:1901028
GeneOntologyBiologicalProcessnuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

TNRC6A TNRC6B TNKS1BP1 TNRC6C

8.30e-0565734GO:0000288
GeneOntologyBiologicalProcessnegative regulation of membrane permeability

SLC25A4 SLC25A5 SLC25A6

1.04e-0426733GO:1905709
GeneOntologyBiologicalProcessnuclear-transcribed mRNA catabolic process

TNRC6A TNRC6B TNKS1BP1 TNRC6C HNRNPAB

1.05e-04132735GO:0000956
GeneOntologyBiologicalProcessnucleotide transmembrane transport

SLC25A4 SLC25A5 SLC25A6

1.78e-0431733GO:1901679
GeneOntologyBiologicalProcessadenine transport

SLC25A4 SLC25A5

1.84e-046732GO:0015853
GeneOntologyBiologicalProcessmitochondrial outer membrane permeabilization

SLC25A4 SLC25A5 SLC25A6

2.15e-0433733GO:0097345
GeneOntologyBiologicalProcessregulation of mitophagy

SLC25A4 SLC25A5 FZD5

3.28e-0438733GO:1901524
GeneOntologyBiologicalProcessregulation of glutamate receptor signaling pathway

FRRS1L UNC13A

3.41e-048732GO:1900449
GeneOntologyBiologicalProcesscarbohydrate derivative transport

ABCC3 SLC25A4 SLC25A5 SLC25A6

3.75e-0496734GO:1901264
GeneOntologyBiologicalProcesspurine-containing compound transmembrane transport

SLC25A4 SLC25A5 SLC25A6

3.82e-0440733GO:0072530
GeneOntologyBiologicalProcesspositive regulation of mitochondrial membrane permeability involved in apoptotic process

SLC25A4 SLC25A5 SLC25A6

3.82e-0440733GO:1902110
GeneOntologyBiologicalProcesspurine ribonucleotide transport

SLC25A4 SLC25A5 SLC25A6

3.82e-0440733GO:0015868
GeneOntologyBiologicalProcessmitochondrial outer membrane permeabilization involved in programmed cell death

SLC25A4 SLC25A5 SLC25A6

4.42e-0442733GO:1902686
GeneOntologyBiologicalProcessadenine nucleotide transport

SLC25A4 SLC25A5 SLC25A6

4.42e-0442733GO:0051503
GeneOntologyBiologicalProcesspurine nucleotide transport

SLC25A4 SLC25A5 SLC25A6

5.08e-0444733GO:0015865
GeneOntologyBiologicalProcesspositive regulation of mitochondrial membrane permeability

SLC25A4 SLC25A5 SLC25A6

5.42e-0445733GO:0035794
GeneOntologyBiologicalProcessregulation of autophagy of mitochondrion

SLC25A4 SLC25A5 FZD5

5.42e-0445733GO:1903146
GeneOntologyBiologicalProcessregulation of mitochondrial membrane permeability involved in apoptotic process

SLC25A4 SLC25A5 SLC25A6

6.97e-0449733GO:1902108
GeneOntologyBiologicalProcessnucleotide transport

SLC25A4 SLC25A5 SLC25A6

7.40e-0450733GO:0006862
GeneOntologyBiologicalProcesspositive regulation of membrane permeability

SLC25A4 SLC25A5 SLC25A6

7.40e-0450733GO:1905710
GeneOntologyBiologicalProcesspurine nucleobase transport

SLC25A4 SLC25A5

7.97e-0412732GO:0006863
GeneOntologyBiologicalProcessinositol phosphate metabolic process

INPP5B INPPL1 ITPKB

8.30e-0452733GO:0043647
GeneOntologyCellularComponentmitochondrial permeability transition pore complex

SLC25A4 SLC25A5

2.57e-047742GO:0005757
GeneOntologyCellularComponentcytoplasmic ribonucleoprotein granule

HABP4 DDX25 TNRC6A TNRC6B TNRC6C HNRNPAB

3.83e-04269746GO:0036464
GeneOntologyCellularComponentribonucleoprotein granule

HABP4 DDX25 TNRC6A TNRC6B TNRC6C HNRNPAB

5.39e-04287746GO:0035770
GeneOntologyCellularComponentinner dynein arm

DNAH12 DNAH2

5.46e-0410742GO:0036156
GeneOntologyCellularComponentproteasome core complex, beta-subunit complex

PSMB4 PSMB5

6.66e-0411742GO:0019774
GeneOntologyCellularComponentdynein complex

DNAH12 DNAH2 DCTN4

9.28e-0454743GO:0030286
DomainAgo_hook

TNRC6A TNRC6B TNRC6C

5.97e-083743PF10427
DomainTNRC6_PABC-bd

TNRC6A TNRC6B TNRC6C

5.97e-083743IPR032226
DomainArgonaute_hook_dom

TNRC6A TNRC6B TNRC6C

5.97e-083743IPR019486
DomainTNRC6-PABC_bdg

TNRC6A TNRC6B TNRC6C

5.97e-083743PF16608
DomainHECT

HECTD2 HERC3 HERC2 HERC1

3.72e-0627744PF00632
DomainHECTc

HECTD2 HERC3 HERC2 HERC1

3.72e-0627744SM00119
DomainHECT_dom

HECTD2 HERC3 HERC2 HERC1

3.72e-0627744IPR000569
DomainHECT

HECTD2 HERC3 HERC2 HERC1

3.72e-0627744PS50237
DomainMit_uncoupling

SLC25A4 SLC25A5 SLC25A6

1.28e-0512743IPR002030
DomainM_domain

TNRC6A TNRC6C

1.55e-052742PF12938
DomainGW182_M_dom

TNRC6A TNRC6C

1.55e-052742IPR026805
DomainRCC1

HERC3 HERC2 HERC1

6.48e-0520743PF00415
DomainRCC1_1

HERC3 HERC2 HERC1

7.54e-0521743PS00625
DomainRCC1_2

HERC3 HERC2 HERC1

7.54e-0521743PS00626
DomainRCC1_3

HERC3 HERC2 HERC1

7.54e-0521743PS50012
DomainReg_chr_condens

HERC3 HERC2 HERC1

8.71e-0522743IPR000408
Domain-

HERC3 HERC2 HERC1

8.71e-05227432.130.10.30
DomainIfi-6-16

IFI27L1 IFI6

9.24e-054742PF06140
DomainIFI6/IFI27

IFI27L1 IFI6

9.24e-054742IPR009311
DomainRCC1/BLIP-II

HERC3 HERC2 HERC1

9.99e-0523743IPR009091
DomainAden_trnslctor

SLC25A4 SLC25A5 SLC25A6

1.82e-0428743IPR002113
DomainMit_carrier

SLC25A4 SLC25A5 SLC25A6

2.73e-0432743IPR002067
DomainNtn_hydrolases_N

GGTLC1 PSMB4 PSMB5

2.99e-0433743IPR029055
DomainRRM

HNRNPDL SAFB TNRC6A TNRC6B TNRC6C HNRNPAB

3.01e-04230746PS50102
Domain-

HNRNPDL SAFB TNRC6A TNRC6B TNRC6C HNRNPAB

4.12e-042447463.30.70.330
DomainNucleotide-bd_a/b_plait

HNRNPDL SAFB TNRC6A TNRC6B TNRC6C HNRNPAB

5.54e-04258746IPR012677
DomainIPPc

INPP5B INPPL1

6.83e-0410742IPR000300
DomainIPPc

INPP5B INPPL1

6.83e-0410742SM00128
DomainProteasome_suB-type

PSMB4 PSMB5

8.32e-0411742IPR023333
DomainPROTEASOME_BETA_1

PSMB4 PSMB5

8.32e-0411742PS00854
DomainPROTEASOME_BETA_2

PSMB4 PSMB5

8.32e-0411742PS51476
DomainProteasome_bsu_CS

PSMB4 PSMB5

9.96e-0412742IPR016050
DomainSOLCAR

SLC25A4 SLC25A5 SLC25A6

1.21e-0353743PS50920
Domain-

SLC25A4 SLC25A5 SLC25A6

1.21e-03537431.50.40.10
DomainMitochondrial_sb/sol_carrier

SLC25A4 SLC25A5 SLC25A6

1.21e-0353743IPR018108
DomainMito_carr

SLC25A4 SLC25A5 SLC25A6

1.21e-0353743PF00153
DomainMt_carrier_dom

SLC25A4 SLC25A5 SLC25A6

1.21e-0353743IPR023395
DomainDynein_heavy_chain_D4_dom

DNAH12 DNAH2

1.37e-0314742IPR024317
DomainDynein_heavy_dom-2

DNAH12 DNAH2

1.37e-0314742IPR013602
DomainDHC_N2

DNAH12 DNAH2

1.37e-0314742PF08393
DomainAAA_8

DNAH12 DNAH2

1.37e-0314742PF12780
DomainATPase_dyneun-rel_AAA

DNAH12 DNAH2

1.37e-0314742IPR011704
DomainAAA_5

DNAH12 DNAH2

1.37e-0314742PF07728
DomainDHC_fam

DNAH12 DNAH2

1.57e-0315742IPR026983
DomainDynein_heavy_dom

DNAH12 DNAH2

1.57e-0315742IPR004273
DomainDynein_heavy

DNAH12 DNAH2

1.57e-0315742PF03028
DomainRRM

HNRNPDL SAFB TNRC6A TNRC6C HNRNPAB

1.70e-03217745SM00360
DomainGlobin-like

HECTD2 HBE1

1.79e-0316742IPR009050
DomainRRM_dom

HNRNPDL SAFB TNRC6A TNRC6C HNRNPAB

2.07e-03227745IPR000504
DomainUBA-like

TNRC6A TNRC6B TNRC6C

2.09e-0364743IPR009060
DomainProteasome

PSMB4 PSMB5

2.54e-0319742PF00227
DomainProteasome_sua/b

PSMB4 PSMB5

2.54e-0319742IPR001353
Domain-

PSMB4 PSMB5

4.04e-03247423.60.20.10
DomaincEGF

LRP4 FBN3

4.73e-0326742IPR026823
Domain-

INPP5B INPPL1

4.73e-03267423.60.10.10
DomaincEGF

LRP4 FBN3

4.73e-0326742PF12662
DomainExo_endo_phos

INPP5B INPPL1

4.73e-0326742PF03372
DomainEndo/exonuclease/phosphatase

INPP5B INPPL1

5.10e-0327742IPR005135
PathwayREACTOME_POST_TRANSCRIPTIONAL_SILENCING_BY_SMALL_RNAS

TNRC6A TNRC6B TNRC6C

2.41e-067593M46421
PathwayREACTOME_REGULATION_OF_PTEN_MRNA_TRANSLATION

TNRC6A TNRC6B TNRC6C

5.75e-069593M27810
PathwayREACTOME_REGULATION_OF_NPAS4_MRNA_TRANSLATION

TNRC6A TNRC6B TNRC6C

5.75e-069593M46436
PathwayREACTOME_REGULATION_OF_CDH11_MRNA_TRANSLATION_BY_MICRORNAS

TNRC6A TNRC6B TNRC6C

8.18e-0610593M48013
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_VGCC_CA2_APOPTOTIC_PATHWAY_N01006

SLC25A4 SLC25A5 SLC25A6

8.18e-0610593M47694
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_NPAS4

NAMPT TNRC6A TNRC6B TNRC6C

1.17e-0534594M46422
PathwayREACTOME_TRANSPORT_OF_NUCLEOSIDES_AND_FREE_PURINE_AND_PYRIMIDINE_BASES_ACROSS_THE_PLASMA_MEMBRANE

SLC25A4 SLC25A5 SLC25A6

1.49e-0512593M27728
PathwayREACTOME_INTERACTIONS_OF_VPR_WITH_HOST_CELLULAR_PROTEINS

RANBP2 SLC25A4 SLC25A5 SLC25A6

1.65e-0537594M1029
PathwayREACTOME_HOST_INTERACTIONS_OF_HIV_FACTORS

RANBP2 SLC25A4 SLC25A5 SLC25A6 PSMB4 PSMB5

1.73e-05131596M5283
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_PSEN1_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

SLC25A4 SLC25A5 SLC25A6

1.93e-0513593M47696
PathwayKEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_SIGMAR1_TO_CA2_APOPTOTIC_PATHWAY

SLC25A4 SLC25A5 SLC25A6

1.93e-0513593M47751
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SNCA_TO_VGCC_CA2_APOPTOTIC_PATHWAY

SLC25A4 SLC25A5 SLC25A6

1.93e-0513593M47703
PathwayREACTOME_REGULATION_OF_NPAS4_GENE_EXPRESSION

TNRC6A TNRC6B TNRC6C

1.93e-0513593M46434
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_VGCC_CA2_APOPTOTIC_PATHWAY_N01004

SLC25A4 SLC25A5 SLC25A6

2.45e-0514593M47692
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_TRANSPORT_OF_CALCIUM

SLC25A4 SLC25A5 SLC25A6

3.06e-0515593M47691
PathwayREACTOME_BETA_CATENIN_INDEPENDENT_WNT_SIGNALING

FZD5 PSMB4 PSMB5 TNRC6A TNRC6B TNRC6C

3.19e-05146596M27288
PathwayWP_WNT_SIGNALING_IN_KIDNEY_DISEASE

FZD5 WNT3A LRP4 INVS

3.32e-0544594MM15878
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_PSEN_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

SLC25A4 SLC25A5 SLC25A6

3.75e-0516593M47695
PathwayREACTOME_MAPK6_MAPK4_SIGNALING

PSMB4 PSMB5 TNRC6A TNRC6B TNRC6C

4.24e-0593595M27572
PathwayREACTOME_REGULATION_OF_RUNX1_EXPRESSION_AND_ACTIVITY

TNRC6A TNRC6B TNRC6C

4.54e-0517593M27788
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABBERANT_ATXN2_3_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

SLC25A4 SLC25A5 SLC25A6

5.43e-0518593M47659
PathwayKEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_TRANSPORT_OF_CALCIUM

SLC25A4 SLC25A5 SLC25A6

5.43e-0518593M47761
PathwayREACTOME_REGULATION_OF_MITF_M_DEPENDENT_GENES_INVOLVED_IN_APOPTOSIS

TNRC6A TNRC6B TNRC6C

6.43e-0519593M48238
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_TRANSPORT_OF_CALCIUM

SLC25A4 SLC25A5 SLC25A6

6.43e-0519593M47677
PathwayKEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

SLC25A4 SLC25A5 SLC25A6

6.43e-0519593M47760
PathwayKEGG_MEDICUS_REFERENCE_MACHR_CA2_APOPTOTIC_PATHWAY

SLC25A4 SLC25A5 SLC25A6

7.55e-0520593M47688
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_MACHR_CA2_APOPTOTIC_PATHWAY

SLC25A4 SLC25A5 SLC25A6

8.78e-0521593M47689
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

SLC25A4 SLC25A5 SLC25A6

1.01e-0422593M47690
PathwayKEGG_MEDICUS_REFERENCE_MGLUR5_CA2_APOPTOTIC_PATHWAY

SLC25A4 SLC25A5 SLC25A6

1.01e-0422593M47675
PathwayWP_ALZHEIMERS_DISEASE

SLC25A4 SLC25A5 SLC25A6 FZD5 WNT3A PSMB4 PSMB5

1.03e-04261597M42565
PathwayKEGG_MEDICUS_REFERENCE_VGCC_CA2_APOPTOTIC_PATHWAY

SLC25A4 SLC25A5 SLC25A6

1.16e-0423593M47666
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

SLC25A4 SLC25A5 SLC25A6

1.16e-0423593M47676
PathwayREACTOME_CA2_PATHWAY

FZD5 TNRC6A TNRC6B TNRC6C

1.29e-0462594M27321
PathwayREACTOME_SYNTHESIS_OF_IP3_AND_IP4_IN_THE_CYTOSOL

INPP5B INPPL1 ITPKB

1.69e-0426593M27053
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SOD1_TO_RETROGRADE_AXONAL_TRANSPORT

DNAH12 DNAH2 DCTN4

1.90e-0427593M47755
PathwayREACTOME_TGFBR3_EXPRESSION

TNRC6A TNRC6B TNRC6C

2.12e-0428593M48253
PathwayREACTOME_SYNTHESIS_OF_IP3_AND_IP4_IN_THE_CYTOSOL

INPP5B INPPL1 ITPKB

2.12e-0428593MM14711
PathwayREACTOME_POST_TRANSCRIPTIONAL_SILENCING_BY_SMALL_RNAS

TNRC6A TNRC6B

2.56e-046592MM15083
PathwayREACTOME_PTEN_REGULATION

PSMB4 PSMB5 TNRC6A TNRC6B TNRC6C

2.83e-04139595M27646
PathwayKEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM

INPP5B INPPL1 DGKG ITPKB

2.84e-0476594M9052
PathwayREACTOME_REGULATION_OF_HOMOTYPIC_CELL_CELL_ADHESION

TNRC6A TNRC6B TNRC6C

3.17e-0432593M48012
PathwayREACTOME_REGULATION_OF_MECP2_EXPRESSION_AND_ACTIVITY

TNRC6A TNRC6B TNRC6C

3.17e-0432593M27900
PathwayREACTOME_HIV_INFECTION

RANBP2 SLC25A4 SLC25A5 SLC25A6 PSMB4 PSMB5

3.96e-04231596M12469
PathwayWP_ALZHEIMERS_DISEASE_AND_MIRNA_EFFECTS

SLC25A4 SLC25A5 SLC25A6 FZD5 WNT3A PSMB4 PSMB5

4.03e-04326597M39379
PathwayREACTOME_ONCOGENE_INDUCED_SENESCENCE

TNRC6A TNRC6B TNRC6C

4.14e-0435593M27190
PathwayREACTOME_SIGNALING_BY_WNT

FZD5 WNT3A PSMB4 PSMB5 TNRC6A TNRC6B TNRC6C

4.34e-04330597M7847
PathwayWP_WNT_SIGNALING_IN_KIDNEY_DISEASE

FZD5 WNT3A INVS

4.51e-0436593M39699
PathwayREACTOME_SIGNALING_BY_RNF43_MUTANTS

FZD5 WNT3A

4.74e-048592M27433
PathwayREACTOME_NR1H3_NR1H2_REGULATE_GENE_EXPRESSION_LINKED_TO_CHOLESTEROL_TRANSPORT_AND_EFFLUX

TNRC6A TNRC6B TNRC6C

4.89e-0437593M29790
PathwayREACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION

MRC1 HECTD2 PSMB4 PSMB5 HERC3 HERC2 HERC1

5.46e-04343597MM15712
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_VENTX

TNRC6A TNRC6B TNRC6C

6.63e-0441593M29748
PathwayBIOCARTA_ETC_PATHWAY

SLC25A4 SLC25A6

7.58e-0410592M15371
PathwayKEGG_MEDICUS_REFERENCE_RETROGRADE_AXONAL_TRANSPORT

DNAH12 DNAH2 DCTN4

7.63e-0443593M47669
PathwayREACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES

SLC25A4 SLC25A5 SLC25A6

7.63e-0443593M881
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_RETROGRADE_AXONAL_TRANSPORT

DNAH12 DNAH2 DCTN4

8.72e-0445593M47670
PathwayREACTOME_TRANSPORT_OF_NUCLEOSIDES_AND_FREE_PURINE_AND_PYRIMIDINE_BASES_ACROSS_THE_PLASMA_MEMBRANE

SLC25A4 SLC25A5

9.24e-0411592MM15471
PathwayKEGG_HUNTINGTONS_DISEASE

SLC25A4 SLC25A5 SLC25A6 DNAH2 DCTN4

9.67e-04182595M13486
PathwayREACTOME_NR1H2_AND_NR1H3_MEDIATED_SIGNALING

TNRC6A TNRC6B TNRC6C

9.91e-0447593M29777
PathwayREACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION

MRC1 HECTD2 PSMB4 PSMB5 HERC3 HERC2 HERC1

1.01e-03381597M1066
PathwayREACTOME_INOSITOL_PHOSPHATE_METABOLISM

INPP5B INPPL1 ITPKB

1.05e-0348593M26964
PathwayREACTOME_INOSITOL_PHOSPHATE_METABOLISM

INPP5B INPPL1 ITPKB

1.05e-0348593MM14589
PathwayREACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES

MRC1 PSMB4 PSMB5

1.05e-0348593MM14528
PathwayREACTOME_GENE_SILENCING_BY_RNA

RANBP2 TNRC6A TNRC6B

1.12e-0349593MM14837
PathwayREACTOME_SIGNALING_BY_TGFBR3

TNRC6A TNRC6B TNRC6C

1.12e-0349593M48250
PathwayREACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES

MRC1 PSMB4 PSMB5

1.19e-0350593M510
PathwayKEGG_INOSITOL_PHOSPHATE_METABOLISM

INPP5B INPPL1 ITPKB

1.48e-0354593M3896
PathwayKEGG_MEDICUS_REFERENCE_WNT_SIGNALING_MODULATION_SOST_LRP4

FZD5 LRP4

1.52e-0314592M47834
PathwayREACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION

HECTD2 PSMB4 PSMB5 HERC3 HERC2 HERC1

1.52e-03299596MM15711
PathwayREACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION

HECTD2 PSMB4 PSMB5 HERC3 HERC2 HERC1

1.76e-03308596M1070
PathwayREACTOME_ADHERENS_JUNCTIONS_INTERACTIONS

TNRC6A TNRC6B TNRC6C

1.82e-0358593M11980
PathwayREACTOME_ASYMMETRIC_LOCALIZATION_OF_PCP_PROTEINS

FZD5 PSMB4 PSMB5

2.01e-0360593MM15150
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_MECP2

TNRC6A TNRC6B TNRC6C

2.31e-0363593M27862
PathwayREACTOME_MAPK_FAMILY_SIGNALING_CASCADES

TYK2 PSMB4 PSMB5 TNRC6A TNRC6B TNRC6C

2.38e-03327596M27565
PathwayREACTOME_ASYMMETRIC_LOCALIZATION_OF_PCP_PROTEINS

FZD5 PSMB4 PSMB5

2.42e-0364593M27396
PathwayPID_BETA_CATENIN_DEG_PATHWAY

FZD5 WNT3A

2.52e-0318592M31
PathwayREACTOME_MITF_M_REGULATED_MELANOCYTE_DEVELOPMENT

WNT3A TNRC6A TNRC6B TNRC6C

2.57e-03137594M48232
PathwayREACTOME_GENE_SILENCING_BY_RNA

RANBP2 TNRC6A TNRC6B TNRC6C

2.71e-03139594M715
PathwayBIOCARTA_PROTEASOME_PATHWAY

PSMB4 PSMB5

2.81e-0319592M194
PathwayREACTOME_FORMATION_OF_PARAXIAL_MESODERM

WNT3A PSMB4 PSMB5

3.00e-0369593M46439
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX1

PSMB4 PSMB5 TNRC6A TNRC6B TNRC6C

3.08e-03237595M27786
PathwayREACTOME_DISEASES_OF_SIGNAL_TRANSDUCTION_BY_GROWTH_FACTOR_RECEPTORS_AND_SECOND_MESSENGERS

TYK2 RANBP2 FZD5 WNT3A PSMB4 PSMB5 TNRC6C

3.11e-03464597M27547
PathwayPID_WNT_CANONICAL_PATHWAY

FZD5 WNT3A

3.12e-0320592M90
PathwayREACTOME_REGULATION_OF_FZD_BY_UBIQUITINATION

FZD5 WNT3A

3.12e-0320592MM15155
PathwayREACTOME_REGULATION_OF_FZD_BY_UBIQUITINATION

FZD5 WNT3A

3.44e-0321592M27401
PathwayREACTOME_SIGNALING_BY_NOTCH

PSMB4 PSMB5 TNRC6A TNRC6B TNRC6C

3.61e-03246595M10189
PathwayREACTOME_ANTIGEN_PROCESSING_CROSS_PRESENTATION

MRC1 PSMB4 PSMB5

3.94e-0376593MM14526
PathwayREACTOME_TCF_DEPENDENT_SIGNALING_IN_RESPONSE_TO_WNT

FZD5 WNT3A PSMB4 PSMB5

4.28e-03158594MM14791
PathwayREACTOME_INFECTIOUS_DISEASE

TYK2 SNF8 MRC1 RANBP2 SLC25A4 SLC25A5 SLC25A6 ENTPD1 PSMB4 PSMB5 MED25

4.72e-0310815911M27548
Pubmed

The human mitochondrial ADP/ATP carriers: kinetic properties and biogenesis of wild-type and mutant proteins in the yeast S. cerevisiae.

SLC25A4 SLC25A5 SLC25A6

1.04e-08377312450408
Pubmed

DNA sequences of two expressed nuclear genes for human mitochondrial ADP/ATP translocase.

SLC25A4 SLC25A5 SLC25A6

1.04e-0837732541251
Pubmed

Impact of scaffolding protein TNRC6 paralogs on gene expression and splicing.

TNRC6A TNRC6B TNRC6C

1.04e-08377334108231
Pubmed

Two distinct genes for ADP/ATP translocase are expressed at the mRNA level in adult human liver.

SLC25A4 SLC25A5 SLC25A6

1.04e-0837732829183
Pubmed

Gawky is a component of cytoplasmic mRNA processing bodies required for early Drosophila development.

TNRC6A TNRC6B TNRC6C

1.04e-08377316880270
Pubmed

Expression of TNRC6 (GW182) Proteins Is Not Necessary for Gene Silencing by Fully Complementary RNA Duplexes.

TNRC6A TNRC6B TNRC6C

1.04e-08377331670606
Pubmed

TRIM24 is an insulin-responsive regulator of P-bodies.

SLC25A5 SLC25A6 TNRC6A TNRC6B TNKS1BP1 TNRC6C

2.55e-088077635803934
Pubmed

Differential Expression of ADP/ATP Carriers as a Biomarker of Metabolic Remodeling and Survival in Kidney Cancers.

SLC25A4 SLC25A5 SLC25A6

4.17e-08477333396658
Pubmed

Two PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencing.

TNRC6A TNRC6B TNRC6C

4.17e-08477321063388
Pubmed

Trinucleotide repeat containing 6a (Tnrc6a)-mediated microRNA function is required for development of yolk sac endoderm.

TNRC6A TNRC6B TNRC6C HBE1

1.58e-072277422187428
Pubmed

The HIV-1 viral protein R induces apoptosis via a direct effect on the mitochondrial permeability transition pore.

SLC25A4 SLC25A5 SLC25A6

2.08e-07677310620603
Pubmed

Expression of leucine-rich repeat kinase 2 (LRRK2) inhibits the processing of uMtCK to induce cell death in a cell culture model system.

SLC25A4 SLC25A5 SLC25A6

3.63e-07777321370995
Pubmed

Functional dissection of the human TNRC6 (GW182-related) family of proteins.

TNRC6A TNRC6B TNRC6C

3.63e-07777319470757
Pubmed

The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins.

TNRC6A TNRC6B TNRC6C

3.63e-07777319383768
Pubmed

TSPO ligands stimulate ZnPPIX transport and ROS accumulation leading to the inhibition of P. falciparum growth in human blood.

SLC25A4 SLC25A5 SLC25A6

5.80e-07877327641616
Pubmed

Heterozygous deletion of chromosome 17p renders prostate cancer vulnerable to inhibition of RNA polymerase II.

HNRNPDL RANBP2 SAFB NAMPT SLC25A5 SLC25A6 PCCA

1.22e-0624477730349055
Pubmed

Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms.

HNRNPDL SLC25A4 SLC25A5 SLC25A6 RPS6KA6 HBE1 HNRNPAB

1.67e-0625677724189400
Pubmed

Mitochondrial membrane permeabilization by HIV-1 Vpr.

SLC25A4 SLC25A5 SLC25A6

2.26e-061277316120388
Pubmed

Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation.

TNRC6A TNRC6B TNRC6C

3.73e-061477319716330
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

RANBP2 NPTX2 EHBP1L1 SAFB CHERP SLC25A4 SLC25A5 SLC25A6 TNRC6B TNKS1BP1 HNRNPAB UNC13A

4.42e-061082771238697112
Pubmed

GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targets.

TNRC6A TNRC6B TNRC6C

4.66e-061577321981923
Pubmed

Role of adenine nucleotide translocator 1 in mtDNA maintenance.

SLC25A4 SLC25A6

4.84e-06277210926541
Pubmed

Role of GW182 protein in the cell.

TNRC6A TNRC6B

4.84e-06277229791863
Pubmed

Changes in the expression of the human adenine nucleotide translocase isoforms condition cellular metabolic/proliferative status.

SLC25A5 SLC25A6

4.84e-06277226842067
Pubmed

The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore.

SLC25A4 SLC25A5

4.84e-06277214749836
Pubmed

Deficiency in the mouse mitochondrial adenine nucleotide translocator isoform 2 gene is associated with cardiac noncompaction.

SLC25A4 SLC25A5

4.84e-06277227048932
Pubmed

Apoptotic and anti-proliferative effects of all-trans retinoic acid. Adenine nucleotide translocase sensitizes HeLa cells to all-trans retinoic acid.

SLC25A4 SLC25A6

4.84e-06277216556444
Pubmed

Acute necrotizing encephalopathy-linked mutations in Nup358 impair interaction of Nup358 with TNRC6/GW182 and miRNA function.

RANBP2 TNRC6A

4.84e-06277233962210
Pubmed

cDNA sequence of a human skeletal muscle ADP/ATP translocator: lack of a leader peptide, divergence from a fibroblast translocator cDNA, and coevolution with mitochondrial DNA genes.

SLC25A4 SLC25A6

4.84e-0627722823266
Pubmed

Expression and sequence analysis of the mouse adenine nucleotide translocase 1 and 2 genes.

SLC25A4 SLC25A5

4.84e-06277210974536
Pubmed

A novel D104G mutation in the adenine nucleotide translocator 1 gene in autosomal dominant progressive external ophthalmoplegia patients with mitochondrial DNA with multiple deletions.

SLC25A4 SLC25A6

4.84e-06277212112115
Pubmed

A novel missense adenine nucleotide translocator-1 gene mutation in a Greek adPEO family.

SLC25A4 SLC25A6

4.84e-06277211756613
Pubmed

TNRC6 proteins modulate hepatitis C virus replication by spatially regulating the binding of miR-122/Ago2 complexes to viral RNA.

SLC25A5 CPQ TNRC6A DNAH2 TNRC6B TNRC6C PCCA

6.81e-0631777730997501
Pubmed

Assembly of the WHIP-TRIM14-PPP6C Mitochondrial Complex Promotes RIG-I-Mediated Antiviral Signaling.

NAMPT SLC25A6 PSMB5 TNKS1BP1 HERC3 DCTN4 PCCA

9.20e-0633277729053956
Pubmed

Structural basis for phosphoinositide substrate recognition, catalysis, and membrane interactions in human inositol polyphosphate 5-phosphatases.

INPP5B INPPL1

1.45e-05377224704254
Pubmed

Secreted Frizzled-related protein potentiation versus inhibition of Wnt3a/β-catenin signaling.

FZD5 WNT3A

1.45e-05377224080158
Pubmed

Carboxyatractyloside effects on brown-fat mitochondria imply that the adenine nucleotide translocator isoforms ANT1 and ANT2 may be responsible for basal and fatty-acid-induced uncoupling respectively.

SLC25A4 SLC25A5

1.45e-05377216831128
Pubmed

Mammalian splicing factor SF1 interacts with SURP domains of U2 snRNP-associated proteins.

HNRNPDL CHERP HNRNPAB

1.56e-052277326420826
Pubmed

Interactome analyses revealed that the U1 snRNP machinery overlaps extensively with the RNAP II machinery and contains multiple ALS/SMA-causative proteins.

HNRNPDL SAFB CHERP SLC25A5 TASOR HNRNPAB

1.75e-0524477629884807
Pubmed

Trinucleotide repeat containing 6c (TNRC6c) is essential for microvascular maturation during distal airspace sacculation in the developing lung.

TNRC6A TNRC6B TNRC6C

1.79e-052377328811219
Pubmed

Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in Parkinson's disease.

SLC25A4 SLC25A5 SLC25A6

2.04e-052477324725412
Pubmed

Rapid evolution of human pseudoautosomal genes and their mouse homologs.

SLC25A4 SLC25A5

2.89e-0547728903724
Pubmed

Human-Specific ARHGAP11B Acts in Mitochondria to Expand Neocortical Progenitors by Glutaminolysis.

SLC25A4 SLC25A5

2.89e-05477231883789
Pubmed

The interaction between cell adhesion molecule L1, matrix metalloproteinase 14, and adenine nucleotide translocator at the plasma membrane regulates L1-mediated neurite outgrowth of murine cerebellar neurons.

SLC25A4 SLC25A5

2.89e-05477222423112
Pubmed

The interactions of GW182 proteins with PABP and deadenylases are required for both translational repression and degradation of miRNA targets.

TNRC6A TNRC6C

2.89e-05477223172285
Pubmed

Inhibition of mitochondrial permeability transition by deletion of the ANT family and CypD.

SLC25A4 SLC25A5

2.89e-05477231489369
Pubmed

The ADP/ATP translocase drives mitophagy independent of nucleotide exchange.

SLC25A4 SLC25A5

2.89e-05477231618756
Pubmed

Ikappa b-alpha, the NF-kappa B inhibitory subunit, interacts with ANT, the mitochondrial ATP/ADP translocator.

SLC25A4 SLC25A5

2.89e-05477211287411
Pubmed

Identification of a novel gene family that includes the interferon-inducible human genes 6-16 and ISG12.

IFI27L1 IFI6

2.89e-05477214728724
Pubmed

Structural basis of binding of P-body-associated proteins GW182 and ataxin-2 by the Mlle domain of poly(A)-binding protein.

TNRC6A TNRC6C

2.89e-05477220181956
Pubmed

Relationships among the subunits of the high molecular weight proteinase, macropain (proteasome).

PSMB4 PSMB5

2.89e-0547722306472
Pubmed

CRISPR activation screen identifies BCL-2 proteins and B3GNT2 as drivers of cancer resistance to T cell-mediated cytotoxicity.

SLC25A4 SLC25A5 SLC25A6 PSMB4 PSMB5 TNKS1BP1 HERC2

4.02e-0541877735338135
Pubmed

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.

RANBP2 SAFB NAMPT SLC25A5 FRRS1L TNRC6A TNRC6B DGKG PCCA HNRNPAB UNC13A

4.10e-051139771136417873
Pubmed

TRIM28-mediated nucleocapsid protein SUMOylation enhances SARS-CoV-2 virulence.

HNRNPDL SAFB SLC25A5 SLC25A6 TNRC6A TNRC6B HNRNPAB

4.80e-0543077738172120
Pubmed

Frameshift mutations of ubiquitination-related genes HERC2, HERC3, TRIP12, UBE2Q1 and UBE4B in gastric and colorectal carcinomas with microsatellite instability.

HERC3 HERC2

4.82e-05577222124266
Pubmed

A secreted WNT-ligand-binding domain of FZD5 generated by a frameshift mutation causes autosomal dominant coloboma.

FZD5 WNT3A

4.82e-05577226908622
Pubmed

Ago-TNRC6 triggers microRNA-mediated decay by promoting two deadenylation steps.

TNRC6B TNRC6C

4.82e-05577219838187
Pubmed

Apoptotic properties of the type 1 interferon induced family of human mitochondrial membrane ISG12 proteins.

IFI27L1 IFI6

4.82e-05577227673746
Pubmed

A novel set of Wnt-Frizzled fusion proteins identifies receptor components that activate beta -catenin-dependent signaling.

FZD5 WNT3A

4.82e-05577212121999
Pubmed

H+ transport is an integral function of the mitochondrial ADP/ATP carrier.

SLC25A4 SLC25A5

4.82e-05577231341297
Pubmed

The human HERC family of ubiquitin ligases: novel members, genomic organization, expression profiling, and evolutionary aspects.

HERC3 HERC1

4.82e-05577215676274
Pubmed

A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-κB Signaling.

HNRNPDL SAFB NAMPT SLC25A4 SLC25A5 SLC25A6 DGKG TNRC6C HNRNPAB

6.01e-0578677929128334
Pubmed

Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.

HECTD2 HERC3 HERC2 HERC1

6.07e-059577429643511
Pubmed

Angelman syndrome-associated point mutations in the Zn2+-binding N-terminal (AZUL) domain of UBE3A ubiquitin ligase inhibit binding to the proteasome.

PSMB4 PSMB5 HERC2

6.49e-053577330257870
Pubmed

In silico discovery of gene-coding variants in murine quantitative trait loci using strain-specific genome sequence databases.

HABP4 HSD17B3

7.22e-05677212537567
Pubmed

ANT-dependent MPTP underlies necrotic myofiber death in muscular dystrophy.

SLC25A4 SLC25A5

7.22e-05677237624892
Pubmed

Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase.

SLC25A5 SLC25A6

7.22e-05677217715127
Pubmed

C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.

HNRNPDL RANBP2 NAMPT SLC25A4 SLC25A5 SLC25A6 PSMB4 PSMB5 TNRC6B DCTN4 HNRNPAB

9.88e-051257771137317656
Pubmed

The ancestral gene for transcribed, low-copy repeats in the Prader-Willi/Angelman region encodes a large protein implicated in protein trafficking, which is deficient in mice with neuromuscular and spermiogenic abnormalities.

HERC2 HERC1

1.01e-0477729949213
Pubmed

Isolation of several human axonemal dynein heavy chain genes: genomic structure of the catalytic site, phylogenetic analysis and chromosomal assignment.

DNAH12 DNAH2

1.01e-0477729256245
Pubmed

Interactomes of Glycogen Synthase Kinase-3 Isoforms.

SLC25A5 INPPL1 TNRC6A TNRC6B TNKS1BP1

1.04e-0420977536779422
Pubmed

Proteomic dissection of cell type-specific H2AX-interacting protein complex associated with hepatocellular carcinoma.

HNRNPDL SLC25A6 PSMB4 HNRNPAB

1.27e-0411577420000738
Pubmed

A DDX6-CNOT1 complex and W-binding pockets in CNOT9 reveal direct links between miRNA target recognition and silencing.

TNRC6A TNRC6C

1.34e-04877224768540
Pubmed

Dysfunction of Wnt signaling and synaptic disassembly in neurodegenerative diseases.

FZD5 WNT3A

1.34e-04877224449494
Pubmed

BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.

HNRNPDL RANBP2 SAFB NAMPT CHERP SLC25A4 SLC25A5 SLC25A6 TNRC6A PCCA HNRNPAB

1.50e-041318771130463901
Pubmed

Mass spectrometry-based proteomic analysis of FSCN1-interacting proteins in laryngeal squamous cell carcinoma cells.

SAFB SLC25A6 PSMB4 PSMB5

1.50e-0412077431298480
Pubmed

Malformation of Tear Ducts Underlies the Epiphora and Precocious Eyelid Opening in Prickle 1 Mutant Mice: Genetic Implications for Tear Duct Genesis.

FZD5 WNT3A INVS

1.58e-044777333141892
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

TYK2 ABCC3 EHBP1L1 TMEM259 INPPL1 LRP4 TNKS1BP1 TNRC6C HERC2 HERC1

1.60e-041105771035748872
Pubmed

Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin.

FZD5 WNT3A

1.72e-04977216890161
Pubmed

A role for the Wnt gene family in hematopoiesis: expansion of multilineage progenitor cells.

FZD5 WNT3A

1.72e-0497729160667
Pubmed

Genome-wide association study identifies loci affecting blood copper, selenium and zinc.

CCDC27 PSMB4 MED25

1.79e-044977323720494
Pubmed

Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity.

RANBP2 SLC25A5 OR2T35 ASL PSMB4 PSMB5

1.85e-0437477623824909
Pubmed

DDX24 promotes metastasis by regulating RPL5 in non-small cell lung cancer.

CCDC27 SLC25A5 SLC25A6 PSMB5 HNRNPAB

1.90e-0423877535864588
Pubmed

Optimized fragmentation schemes and data analysis strategies for proteome-wide cross-link identification.

HNRNPDL SLC25A4 INPPL1 PSMB4 PSMB5 TNKS1BP1 PCCA

1.93e-0453877728524877
Pubmed

TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.

HNRNPDL RANBP2 CHERP SLC25A5 SLC25A6 PSMB4 TNRC6B HERC2 HNRNPAB

2.00e-0492277927609421
Pubmed

Transglutaminase Type 2 Regulates ER-Mitochondria Contact Sites by Interacting with GRP75.

SLC25A5 SLC25A6

2.15e-041077230590033
Pubmed

miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4-NOT.

TNRC6A TNRC6C

2.15e-041077221984185
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

RANBP2 SAFB NAMPT CHERP TNRC6B TNKS1BP1 PCCA TASOR HNRNPAB

2.20e-0493477933916271
Pubmed

The mitochondrial transporter family SLC25: identification, properties and physiopathology.

SLC25A4 SLC25A5 SLC25A6

2.26e-045377323266187
Pubmed

PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase.

HNRNPDL SAFB TNRC6B TNKS1BP1 HERC2

2.26e-0424777532989298
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

HNRNPDL RANBP2 SAFB CHERP SLC25A4 SLC25A5 PCCA TASOR HNRNPAB

2.57e-0495477936373674
Pubmed

Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex.

FZD5 WNT3A

2.63e-041177218606138
Pubmed

ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner.

FZD5 WNT3A

2.63e-041177222575959
Pubmed

The complete primary structure of mouse 20S proteasomes.

PSMB4 PSMB5

2.63e-041177210436176
Pubmed

TBL2, a novel transducin family member in the WBS deletion: characterization of the complete sequence, genomic structure, transcriptional variants and the mouse ortholog.

ASL PCOLCE

2.63e-041177210575226
Pubmed

miRNA repression involves GW182-mediated recruitment of CCR4-NOT through conserved W-containing motifs.

TNRC6A TNRC6C

2.63e-041177221984184
Pubmed

Multi-omics profiling identifies a deregulated FUS-MAP1B axis in ALS/FTD-associated UBQLN2 mutants.

SLC25A4 SLC25A5 SLC25A6 PSMB5 HKDC1

2.67e-0425677535777956
Pubmed

Circular RNA circPVT1 promotes nasopharyngeal carcinoma metastasis via the β-TrCP/c-Myc/SRSF1 positive feedback loop.

HNRNPDL SAFB SLC25A5 HBE1 HNRNPAB

2.86e-0426077536199071
Pubmed

IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA.

HNRNPDL PCCA HNRNPAB

2.95e-045877321642987
Pubmed

Identification and proteomic analysis of distinct UBE3A/E6AP protein complexes.

PSMB4 PSMB5 HERC2

2.95e-045877322645313
InteractionSLC25A31 interactions

SLC25A4 SLC25A5 SLC25A6 UPK1A PSMB5

3.31e-0660775int:SLC25A31
Cytoband9q31

FRRS1L INVS

3.72e-04177729q31
CytobandEnsembl 112 genes in cytogenetic band chr7q22

NPTX2 NAMPT MUC12 PCOLCE

5.19e-04219774chr7q22
Cytoband3p14.3

DNAH12 TASOR

1.17e-03307723p14.3
Cytoband7q22

MUC12 PCOLCE

1.88e-03387727q22
CytobandEnsembl 112 genes in cytogenetic band chr19p13

TYK2 SAFB CHERP TMEM259 UNC13A FBN3

2.24e-03797776chr19p13
GeneFamilyAtaxins|Trinucleotide repeat containing

TNRC6A TNRC6B TNRC6C

4.13e-0525493775
GeneFamilyDyneins, axonemal

DNAH12 DNAH2

9.53e-0417492536
CoexpressionAtlasdev gonad_e13.5_M_InterstitTestis_Sma_k-means-cluster#2_top-relative-expression-ranked_200

PRSS35 HSD17B3 PCOLCE

2.11e-0516733gudmap_dev gonad_e13.5_M_InterstitTestis_Sma_k2_200
DrugClodronate

SLC25A4 SLC25A5 SLC25A6

3.72e-083773DB00720
Drugdehydroabietylamine

SLC25A4 SLC25A5 SLC25A6

1.48e-074773ctd:C000600819
Drugclosantel

SLC25A4 SLC25A5 SLC25A6

1.29e-067773ctd:C023342
DrugAC1L4X2K

SLC25A4 SLC25A5 SLC25A6

4.39e-0610773CID000193824
Drugracephenicol

SLC25A4 SLC25A5 SLC25A6 IFI6

1.01e-0540774CID000005433
Drugoleoylcarnitine

SLC25A4 SLC25A5 SLC25A6

2.02e-0516773CID006441392
Drugbeta-hydroxypalmitoyl-CoA

SLC25A4 SLC25A5 SLC25A6

2.44e-0517773CID000440600
Drugcarboxyatractyloside

SLC25A4 SLC25A5

3.38e-053772ctd:C003853
Drugagaric acid

SLC25A4 SLC25A5 SLC25A6

4.07e-0520773CID000012629
Drugphenylsuccinate

SLC25A4 SLC25A5 SLC25A6

4.73e-0521773CID000095459
DrugPipenzolate bromide [125-51-9]; Down 200; 9.2uM; MCF7; HT_HG-U133A

ABCC3 INPP5B TNRC6B ARPIN IFI6 ITPKB

5.23e-051957766821_DN
DrugSulfamerazine [127-79-7]; Down 200; 15.2uM; PC3; HT_HG-U133A

ABCC3 EHBP1L1 TMEM259 INPP5B MED25 HERC3

5.23e-051957763718_DN
DrugIsocorydine (+) [475-67-2]; Up 200; 11.8uM; MCF7; HT_HG-U133A

NPTX2 EHBP1L1 CPQ RPS6KA6 DGKG IFI6

5.69e-051987766843_UP
DrugSulfamethoxypyridazine [80-35-3]; Up 200; 14.2uM; MCF7; HT_HG-U133A

INPP5B DDX25 MED25 HSD17B3 IFI6 INVS

5.85e-051997763609_UP
Diseaseautosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 2 (implicated_via_orthology)

SLC25A4 SLC25A5 SLC25A6

6.05e-084743DOID:0111517 (implicated_via_orthology)
Diseasehypertrophic cardiomyopathy (implicated_via_orthology)

SLC25A4 SLC25A5 SLC25A6

5.28e-0529743DOID:11984 (implicated_via_orthology)
Diseaseautosomal dominant limb-girdle muscular dystrophy type 3 (implicated_via_orthology)

HNRNPDL HNRNPAB

9.25e-056742DOID:0110306 (implicated_via_orthology)
Diseasemitochondrial metabolism disease (implicated_via_orthology)

SLC25A4 SLC25A5 SLC25A6

9.35e-0535743DOID:700 (implicated_via_orthology)
Diseaseamino acid metabolic disorder (is_implicated_in)

ASL PCCA

3.36e-0411742DOID:9252 (is_implicated_in)
Diseaseepilepsy (implicated_via_orthology)

SLC25A4 SLC25A5 SLC25A6 UNC13A

7.64e-04163744DOID:1826 (implicated_via_orthology)
Diseaseglucose metabolism disease (implicated_via_orthology)

HKDC1 DGKG

2.25e-0328742DOID:4194 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
RGEGEMSKSLWFKGG

UNC13A

466

Q9UPW8
FKGAWSNVLRGMGGA

SLC25A6

271

P12236
SAGTDLALGMGWDAT

AGPAT4-IT1

16

Q9H0P7
LDSWDVGQGAMDDGG

CPQ

291

Q9Y646
IIGVGGAKSMADGWE

ALLC

221

Q8N6M5
RAGTGGAGSKWVVMD

AFDN-DT

16

Q9Y6Z5
FKGAWSNVLRGMGGA

SLC25A5

271

P05141
TGDGKTGASWTDNIM

ARPIN

186

Q7Z6K5
MVSWGGEKRGGAEGS

CCDC144CP

1

Q8IYA2
MAGGQGRWDGALEAA

FBN3

26

Q75N90
MASLLWGGDAGAAES

DDX25

1

Q9UHL0
EDTGAWGGVSQMGSV

CCDC27

351

Q2M243
SGFEGMFTKKEGQWD

RANBP2

1656

P49792
GFEGMFTKKEGQWDC

RANBP2

1716

P49792
MTTDEGTGGRGFLLW

PCOLCE

131

Q15113
MEAFLGSRSGLWAGG

PSMB4

1

P28070
DDGKMFIGGLSWDTS

HNRNPDL

146

O14979
MDALCGSGELGSKFW

ABCC3

1

O15438
VVGSWVGGSLDGFML

OR2T2

146

Q6IF00
WSKMNVEEAGGEALG

HBE1

16

P02100
WGEGDDGKLGHFSRM

HERC2

3071

O95714
FSWGAGSDGQLGLMT

HERC3

106

Q15034
MASESGKLWGGRFVG

ASL

1

P04424
VSADGSMVWAFGDGD

HERC1

4201

Q15751
SMVWAFGDGDYGKLG

HERC1

4206

Q15751
GEAGLDMGGLTKEWF

HECTD2

451

Q5U5R9
SEKGYGLEVDMWAAG

DCLK3

526

Q9C098
DNMGGCGVRTWGSGK

HABP4

231

Q5JVS0
MAGGWAAASDSRKGG

GGTLC1

206

Q9BX51
DKNMSGWYRFVGEGG

GP2

86

P55259
VGGMTASFFGGWLGD

SLC2A2

106

P11168
KRWMDGGFLDLNGES

DNAH12

701

Q6ZR08
EAEAGVWGMSEGKSG

EHBP1L1

936

Q8N3D4
MGAEWELGAEAGGSL

EBPL

1

Q9BY08
TWLDGIKFMGGGGES

MED25

96

Q71SY5
MGKESGWDSGRAAVA

IFI27L1

1

Q96BM0
WDREMEVFSGGGASS

RPS6KA6

11

Q9UK32
VGSWVGGSLDGFMLT

OR2T35

146

Q8NGX2
SAGGGGKGMRIAWDD

PCCA

221

P05165
GKIQGSDAGWTLGYM

ENTPD1

441

P49961
FVSEDGHWKLGGMET

SCYL3

131

Q8IZE3
MDDSGSKGDGRHAWT

DGKG

261

P49619
FLAAGMKWGNEAIAG

FZD5

341

Q13467
LLMDDMGWGDLGVYG

GALNS

36

P34059
GGFDMEVKGWGGEDV

CSGALNACT2

446

Q8N6G5
KMGWSGSGGLGAKEQ

CHERP

851

Q8IWX8
DGWVAVGFSSDKKMG

FRRS1L

141

Q9P0K9
SGFWKALTFMAVGGG

IFI6

36

P09912
MASWGGEKRGGAEGS

CCDC144B

1

Q3MJ40
AAAAGGDLGWMAETA

TMEM259

531

Q4ZIN3
GAGSVLFWGGAMEKT

INPP5B

196

P32019
MASWGGEKRGGAEGS

CCDC144A

1

A2RUR9
VGMADKSVASGGWQE

DCTN4

121

Q9UJW0
SMGQWAVITGAGDGI

HSD17B3

46

P37058
GPSSKWEAVGMFSGD

DNAH2

1576

Q9P225
EGRTSFMWAAGKGSD

INVS

321

Q9Y283
IGGASNEAGKWMDDT

MRC1

1056

P22897
ASKSMQEGWGSGGDE

TNRC6C

871

Q9HCJ0
EDAGKMFVGGLSWDT

HNRNPAB

66

Q99729
KMCINTEWGGFGDNG

HKDC1

701

Q2TB90
GTMEKAGLAWTRGTG

ITPKB

511

P27987
GRASGLGEAGMSAWL

INPPL1

1191

O15357
KMWSIENIAFGSGGG

NAMPT

371

P43490
GMWEAFQDGEKLGTG

NPTX2

321

P47972
DGWGGYGSDKRMSEG

SAFB

796

Q15424
GVDPLASGKGFWSEM

SNF8

76

Q96H20
ASGKGFWSEMLGVGD

SNF8

81

Q96H20
SWESGGGGDDEMKQA

TASOR

16

Q9UK61
FKGAWSNVLRGMGGA

SLC25A4

271

P12235
KGWARGGMGDATLDY

PRSS35

261

Q8N3Z0
MGKRGWVGEFSLSVG

TNKS1BP1

1081

Q9C0C2
ESAVGQMGWSGGLSL

TNKS1BP1

1186

Q9C0C2
LMGVSGKDDVFAGAW

UPK1A

51

O00322
KWGGCSEDIEFGGMV

WNT3A

151

P56704
MMGSGSGRFGLWLDG

TLDC2

166

A0PJX2
LGTMAGGAADCSFWE

PSMB5

101

P28074
QGGWEDDSAATGMVK

TNRC6A

801

Q8NDV7
WGEGNKMTSGVSQGE

TNRC6B

496

Q9UPQ9
DMEEGKEGGTWLGIS

TANGO2

51

Q6ICL3
GGANSLSTAMDKWGF

TYK2

786

P29597
KDEGASAGWSVMFAG

MUC12

76

Q9UKN1
WGENAKLERSGMDGS

LRP4

1186

O75096