Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessregulation of protein transport

CAMK4 LRP2 PLA2G1B UMOD SYBU KIF5B MDM2 F2R PTGER3 SIRT1 OPRM1

4.37e-055609311GO:0051223
GeneOntologyBiologicalProcesskidney development

FRAS1 GLI2 PDGFD MTSS1 PKD1 LRP2 UMOD NOTCH2 PCSK9

4.65e-05372939GO:0001822
GeneOntologyBiologicalProcessregulation of establishment of protein localization

CAMK4 LRP2 PLA2G1B UMOD SYBU KIF5B HUWE1 MDM2 F2R PTGER3 SIRT1 OPRM1

4.98e-056749312GO:0070201
GeneOntologyBiologicalProcesspositive regulation of podocyte apoptotic process

PPARGC1A PLA2G1B

6.02e-053932GO:1904635
GeneOntologyBiologicalProcessregulation of podocyte apoptotic process

PPARGC1A PLA2G1B

6.02e-053932GO:1904633
GeneOntologyBiologicalProcesspositive regulation of low-density lipoprotein particle receptor catabolic process

ABCA2 PCSK9

6.02e-053932GO:0032805
GeneOntologyBiologicalProcessrenal system development

FRAS1 GLI2 PDGFD MTSS1 PKD1 LRP2 UMOD NOTCH2 PCSK9

6.18e-05386939GO:0072001
GeneOntologyBiologicalProcessregulation of cellular localization

ABCA2 TRIM67 MYCBP2 CAMK4 LRP2 PLA2G1B UMOD SYBU KIF5B HUWE1 MDM2 F2R PTGER3 SIRT1 PCSK9 OPRM1

9.58e-0512129316GO:0060341
GeneOntologyBiologicalProcessregulation of protein localization

ABCA2 TRIM67 MYCBP2 CAMK4 LRP2 PLA2G1B UMOD SYBU KIF5B HUWE1 MDM2 F2R PTGER3 SIRT1 OPRM1

9.98e-0510879315GO:0032880
GeneOntologyBiologicalProcesscalcium-independent cell-matrix adhesion

PKD1 VWA2

1.20e-044932GO:0007161
GeneOntologyBiologicalProcessnegative regulation of receptor-mediated endocytosis involved in cholesterol transport

ABCA2 PCSK9

1.99e-045932GO:1905601
GeneOntologyBiologicalProcesspodocyte apoptotic process

PPARGC1A PLA2G1B

1.99e-045932GO:1903210
GeneOntologyBiologicalProcessnegative regulation of intracellular sterol transport

ABCA2 PCSK9

1.99e-045932GO:0032381
GeneOntologyBiologicalProcessnegative regulation of intracellular cholesterol transport

ABCA2 PCSK9

1.99e-045932GO:0032384
GeneOntologyBiologicalProcessnegative regulation of intracellular lipid transport

ABCA2 PCSK9

1.99e-045932GO:0032378
GeneOntologyBiologicalProcessmyeloid leukocyte migration

CAMK1D DUSP1 PDGFD PLA2G1B UMOD CCL13 PTGER3

2.53e-04276937GO:0097529
GeneOntologyCellularComponentintermediate filament cytoskeleton

KRTAP13-4 KRTAP13-2 KRTAP13-3 KRTAP1-5 KRT40 KRTAP1-1 KRTAP1-3 KRTAP13-1 KRTAP16-1 PHLDB2 KRTAP10-8

2.49e-082639311GO:0045111
GeneOntologyCellularComponentintermediate filament

KRTAP13-4 KRTAP13-2 KRTAP13-3 KRTAP1-5 KRT40 KRTAP1-1 KRTAP1-3 KRTAP13-1 KRTAP16-1 KRTAP10-8

6.88e-082279310GO:0005882
GeneOntologyCellularComponentpolymeric cytoskeletal fiber

KRTAP13-4 KRTAP13-2 KRTAP13-3 TCP11L1 KRTAP1-5 TTLL4 KRT40 KRTAP1-1 KRTAP1-3 RUSC1 CDK5RAP2 AKAP13 SYBU KIF5B KRTAP13-1 KRTAP16-1 KIF25 KRTAP10-8

7.42e-088999318GO:0099513
GeneOntologyCellularComponentsupramolecular fiber

KRTAP13-4 KRTAP13-2 KRTAP13-3 TCP11L1 KRTAP1-5 TTLL4 KRT40 KRTAP1-1 KRTAP1-3 RUSC1 CDK5RAP2 AKAP13 SYBU KIF5B KRTAP13-1 KRTAP16-1 KIF25 KRTAP10-8

3.79e-0611799318GO:0099512
GeneOntologyCellularComponentsupramolecular polymer

KRTAP13-4 KRTAP13-2 KRTAP13-3 TCP11L1 KRTAP1-5 TTLL4 KRT40 KRTAP1-1 KRTAP1-3 RUSC1 CDK5RAP2 AKAP13 SYBU KIF5B KRTAP13-1 KRTAP16-1 KIF25 KRTAP10-8

4.16e-0611879318GO:0099081
GeneOntologyCellularComponentkeratin filament

KRTAP1-5 KRTAP1-1 KRTAP1-3 KRTAP16-1 KRTAP10-8

7.30e-0597935GO:0045095
MousePhenoenlarged pancreas

CAMK1D PKD1 SIRT1 OPRM1

7.97e-0625734MP:0003450
MousePhenoabnormal fluid regulation

ROBO4 GGNBP2 GLI2 DUSP1 PKD1 AKAP13 MUC5B REV3L F2R PTGER3 SVEP1 SIRT1 VCAM1 NOTCH2 FBXL5

1.91e-058267315MP:0001784
MousePhenoexocrine pancreas atrophy

PKD1 SIRT1

2.69e-052732MP:0009164
MousePhenoloss of cortex neurons

MYCBP2 CDK5RAP2 WDR62

4.77e-0514733MP:0003241
DomainPMG

KRTAP13-4 KRTAP13-2 KRTAP13-3 KRTAP13-1 KRTAP10-8

3.62e-0913945PF05287
DomainKRTAP_PMG

KRTAP13-4 KRTAP13-2 KRTAP13-3 KRTAP13-1 KRTAP10-8

3.62e-0913945IPR007951
DomainKAP

KRTAP1-5 KRTAP1-1 KRTAP1-3 KRTAP16-1 KRTAP10-8

1.08e-0558945IPR002494
DomainEGF

VLDLR FRAS1 LRP2 UMOD VWA2 SVEP1 NOTCH2 PEAR1

2.45e-05235948SM00181
DomainEGF_CA

VLDLR LRP2 UMOD VWA2 SVEP1 NOTCH2

3.50e-05122946SM00179
DomainEGF-like_dom

VLDLR FRAS1 LRP2 UMOD VWA2 SVEP1 NOTCH2 PEAR1

3.70e-05249948IPR000742
DomainEGF-like_Ca-bd_dom

VLDLR LRP2 UMOD VWA2 SVEP1 NOTCH2

3.83e-05124946IPR001881
DomainEGF

VLDLR LRP2 UMOD VWA2 SVEP1 NOTCH2

4.19e-05126946PF00008
DomainEGF_1

VLDLR LRP2 UMOD VWA2 USH2A SVEP1 NOTCH2 PEAR1

4.38e-05255948PS00022
DomainEGF_CA

VLDLR LRP2 UMOD SVEP1 NOTCH2

7.32e-0586945PF07645
DomainEGF_Ca-bd_CS

VLDLR LRP2 UMOD SVEP1 NOTCH2

1.30e-0497945IPR018097
DomainGrowth_fac_rcpt_

VLDLR FRAS1 LRP2 UMOD SVEP1 NOTCH2

1.37e-04156946IPR009030
DomainEGF_CA

VLDLR LRP2 UMOD SVEP1 NOTCH2

1.43e-0499945PS01187
DomainASX_HYDROXYL

VLDLR LRP2 UMOD SVEP1 NOTCH2

1.50e-04100945PS00010
DomainEGF_3

VLDLR LRP2 UMOD VWA2 SVEP1 NOTCH2 PEAR1

1.85e-04235947PS50026
DomainEGF-type_Asp/Asn_hydroxyl_site

VLDLR LRP2 UMOD SVEP1 NOTCH2

1.97e-04106945IPR000152
DomainProtocadherin

PCDH11Y PCDH11X

2.48e-045942PF08374
DomainProtocadherin

PCDH11Y PCDH11X

2.48e-045942IPR013585
DomainEGF-like_CS

VLDLR LRP2 UMOD VWA2 SVEP1 NOTCH2 PEAR1

3.49e-04261947IPR013032
DomainEGF_2

VLDLR LRP2 UMOD VWA2 SVEP1 NOTCH2 PEAR1

3.83e-04265947PS01186
DomainKeratin_B2

KRTAP1-5 KRTAP1-1 KRTAP1-3

1.07e-0340943PF01500
Domain-

UMOD SVEP1

1.34e-03119422.40.155.10
DomainGFP-like

UMOD SVEP1

1.34e-0311942IPR023413
DomainABC_A

ABCA2 ABCA4

1.60e-0312942IPR026082
DomainLDLRA_1

VLDLR PKD1 LRP2

1.81e-0348943PS01209
DomainLDLRA_2

VLDLR PKD1 LRP2

1.92e-0349943PS50068
DomainBTB

KCND2 KCTD16 BACH1 KCTD8 KBTBD11

2.16e-03180945SM00225
DomainTIL_dom

LRP2 MUC5B

2.19e-0314942IPR002919
DomainLdl_recept_b

VLDLR LRP2

2.19e-0314942PF00058
DomainLDLRB

VLDLR LRP2

2.19e-0314942PS51120
DomainBTB_2

KCND2 KCTD16 KCTD8

2.41e-0353943PF02214
DomainT1-type_BTB

KCND2 KCTD16 KCTD8

2.41e-0353943IPR003131
DomainBTB/POZ_dom

KCND2 KCTD16 BACH1 KCTD8 KBTBD11

2.43e-03185945IPR000210
DomainLY

VLDLR LRP2

2.52e-0315942SM00135
DomainLDLR_classB_rpt

VLDLR LRP2

2.52e-0315942IPR000033
DomainSKP1/BTB/POZ

KCND2 KCTD16 BACH1 KCTD8 KBTBD11

2.67e-03189945IPR011333
DomainRUN

SGSM2 RUSC1

3.64e-0318942SM00593
DomainRUN

SGSM2 RUSC1

4.05e-0319942PS50826
DomainVWC_out

FRAS1 MUC5B

4.05e-0319942SM00215
DomainRUN

SGSM2 RUSC1

4.05e-0319942PF02759
DomainRun_dom

SGSM2 RUSC1

4.05e-0319942IPR004012
DomainRhoGEF

ARHGEF12 AKAP13 FGD5

4.88e-0368943SM00325
DomainRhoGEF

ARHGEF12 AKAP13 FGD5

5.30e-0370943PF00621
DomainDH_2

ARHGEF12 AKAP13 FGD5

5.30e-0370943PS50010
DomainDH-domain

ARHGEF12 AKAP13 FGD5

5.51e-0371943IPR000219
Domain-

ARHGEF12 AKAP13 FGD5

5.51e-03719431.20.900.10
PathwayREACTOME_KERATINIZATION

KRTAP13-4 KRTAP13-2 KRTAP13-3 KRTAP1-5 KRT40 KRTAP1-1 KRTAP1-3 KRTAP13-1 KRTAP16-1 KRTAP10-8

4.42e-091537110MM15343
PathwayREACTOME_KERATINIZATION

KRTAP13-4 KRTAP13-2 KRTAP13-3 KRTAP1-5 KRT40 KRTAP1-1 KRTAP1-3 KRTAP13-1 KRTAP16-1 LCE1F KRTAP10-8

1.02e-082177111M27640
PathwayREACTOME_DEVELOPMENTAL_BIOLOGY

MYF5 VLDLR KRTAP13-4 KRTAP13-2 KRTAP13-3 KRTAP1-5 KRT40 KRTAP1-1 KRTAP1-3 ARHGEF12 KRTAP13-1 KRTAP16-1 SIRT1 KRTAP10-8

1.64e-075027114MM14537
PathwayWP_ENERGY_METABOLISM

PRKAG3 PPARGC1A CAMK4 SIRT1

9.72e-0548714M39590
PathwayWP_NETRINUNC5B_SIGNALING

MYF5 ROBO4 ARHGEF12 VCAM1

1.33e-0452714M39782
PathwayREACTOME_DEVELOPMENTAL_BIOLOGY

MYF5 PPARGC1A VLDLR KRTAP13-4 KRTAP13-2 KRTAP13-3 KRTAP1-5 TRPC5 KRT40 KRTAP1-1 KRTAP1-3 ARHGEF12 MESP2 KRTAP13-1 KRTAP16-1 SIRT1 LCE1F KRTAP10-8

1.95e-0414327118M509
Pubmed

Molecular evolution of the keratin associated protein gene family in mammals, role in the evolution of mammalian hair.

KRTAP13-4 KRTAP13-2 KRTAP13-3 KRTAP1-5 KRTAP1-1 KRTAP1-3 KRTAP13-1

9.17e-106996718721477
Pubmed

Polymorphisms in the human high sulfur hair keratin-associated protein 1, KAP1, gene family.

KRTAP1-5 KRTAP1-1 KRTAP1-3

8.14e-08496312228244
Pubmed

Characterization of a cluster of human high/ultrahigh sulfur keratin-associated protein genes embedded in the type I keratin gene domain on chromosome 17q12-21.

KRTAP1-5 KRTAP1-1 KRTAP1-3 KRTAP16-1

3.36e-063796411279113
Pubmed

The bHLH regulator pMesogenin1 is required for maturation and segmentation of paraxial mesoderm.

MYF5 MESP2 NOTCH2

4.40e-061296311124811
Pubmed

Compartmentalised expression of Delta-like 1 in epithelial somites is required for the formation of intervertebral joints.

MYF5 MESP2 NOTCH2

4.40e-061296317572911
Pubmed

Characterization of a first domain of human high glycine-tyrosine and high sulfur keratin-associated protein (KAP) genes on chromosome 21q22.1.

KRTAP13-4 KRTAP13-2 KRTAP13-3 KRTAP13-1

4.62e-064096412359730
Pubmed

Myricetin improves endurance capacity and mitochondrial density by activating SIRT1 and PGC-1α.

PPARGC1A SIRT1

7.54e-06296228740165
Pubmed

Repressed SIRT1/PGC-1α pathway and mitochondrial disintegration in iPSC-derived RPE disease model of age-related macular degeneration.

PPARGC1A SIRT1

7.54e-06296227998274
Pubmed

Regulation of diabetic cardiomyopathy by caloric restriction is mediated by intracellular signaling pathways involving 'SIRT1 and PGC-1α'.

PPARGC1A SIRT1

7.54e-06296230071860
Pubmed

Conservation of PCDHX in mammals; expression of human X/Y genes predominantly in brain.

PCDH11Y PCDH11X

7.54e-06296211003707
Pubmed

Sirtuin 1-mediated effects of exercise and resveratrol on mitochondrial biogenesis.

PPARGC1A SIRT1

7.54e-06296223329826
Pubmed

Pcdh11x Negatively Regulates Dendritic Branching.

PCDH11Y PCDH11X

7.54e-06296225687328
Pubmed

The anti-nephritic activity of a polysaccharide from okra (Abelmoschus esculentus (L.) Moench) via modulation of AMPK-Sirt1-PGC-1α signaling axis mediated anti-oxidative in type 2 diabetes model mice.

PPARGC1A SIRT1

7.54e-06296231442509
Pubmed

Sirt1 and the Mitochondria.

PPARGC1A SIRT1

7.54e-06296226831453
Pubmed

Gain-of-function R225Q mutation in AMP-activated protein kinase gamma3 subunit increases mitochondrial biogenesis in glycolytic skeletal muscle.

PRKAG3 PPARGC1A

7.54e-06296218838377
Pubmed

Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha.

PPARGC1A SIRT1

7.54e-06296217347648
Pubmed

Nicotinamide riboside attenuates alcohol induced liver injuries via activation of SirT1/PGC-1α/mitochondrial biosynthesis pathway.

PPARGC1A SIRT1

7.54e-06296229679894
Pubmed

SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}.

PPARGC1A SIRT1

7.54e-06296215716268
Pubmed

Cadherin expression delineates the divisions of the postnatal and adult mouse amygdala.

PCDH11Y PCDH11X

7.54e-06296222592879
Pubmed

Function of hesperidin alleviating inflammation and oxidative stress responses in COPD mice might be related to SIRT1/PGC-1α/NF-κB signaling axis.

PPARGC1A SIRT1

7.54e-06296232164488
Pubmed

Protocadherin X ( PCDHX) and Y ( PCDHY) genes; multiple mRNA isoforms encoding variant signal peptides and cytoplasmic domains.

PCDH11Y PCDH11X

7.54e-06296214727141
Pubmed

Novel putative SREBP and LXR target genes identified by microarray analysis in liver of cholesterol-fed mice.

CAMK1D PCSK9

7.54e-06296212897189
Pubmed

Lack of association between protocadherin 11-X/Y (PCDH11X and PCDH11Y) polymorphisms and late onset Alzheimer's disease.

PCDH11Y PCDH11X

7.54e-06296221276771
Pubmed

PGC-1α modulates necrosis, inflammatory response, and fibrotic tissue formation in injured skeletal muscle.

MYF5 PPARGC1A

7.54e-06296227833743
Pubmed

Sirt1 gene confers Adriamycin resistance in DLBCL via activating the PCG-1α mitochondrial metabolic pathway.

PPARGC1A SIRT1

7.54e-06296232570218
Pubmed

Sulforaphane protects intestinal epithelial cells against lipopolysaccharide-induced injury by activating the AMPK/SIRT1/PGC-1ɑ pathway.

PPARGC1A SIRT1

7.54e-06296234308769
Pubmed

Proprotein convertase subtilisin/kexin type 9 targets megalin in the kidney proximal tubule and aggravates proteinuria in nephrotic syndrome.

LRP2 PCSK9

7.54e-06296237406929
Pubmed

Electroacupuncture Upregulates SIRT1-Dependent PGC-1α Expression in SAMP8 Mice.

PPARGC1A SIRT1

7.54e-06296226530101
Pubmed

Accelerated evolution of Protocadherin11X/Y: a candidate gene-pair for cerebral asymmetry and language.

PCDH11Y PCDH11X

7.54e-06296216874762
Pubmed

PCDH11 is X/Y homologous in Homo sapiens but not in Gorilla gorilla and Pan troglodytes.

PCDH11Y PCDH11X

7.54e-06296216825765
Pubmed

Sirtuin 1 inhibition delays cyst formation in autosomal-dominant polycystic kidney disease.

PKD1 SIRT1

7.54e-06296223778143
Pubmed

Caloric restriction increases the resistance of aged heart to myocardial ischemia/reperfusion injury via modulating AMPK-SIRT1-PGC1a energy metabolism pathway.

PPARGC1A SIRT1

7.54e-06296236739302
Pubmed

SIRT1/PGC-1α signaling protects hepatocytes against mitochondrial oxidative stress induced by bile acids.

PPARGC1A SIRT1

7.54e-06296225789761
Pubmed

The protocadherin 11X/Y (PCDH11X/Y) gene pair as determinant of cerebral asymmetry in modern Homo sapiens.

PCDH11Y PCDH11X

7.54e-06296223600975
Pubmed

An enriched environment ameliorates maternal sleep deprivation-induced cognitive impairment in aged mice by improving mitochondrial function via the Sirt1/PGC-1α pathway.

PPARGC1A SIRT1

7.54e-06296238231482
Pubmed

Uncoupling of peripheral and master clock gene rhythms by reversed feeding leads to an exacerbated inflammatory response after polymicrobial sepsis in mice.

PPARGC1A SIRT1

7.54e-06296224300828
Pubmed

A comparative analysis of the pig, mouse, and human PCDHX genes.

PCDH11Y PCDH11X

7.54e-06296215112107
Pubmed

[Down-regulation of SIRT1 and PGC-1α expression caused by hyperoxia induces mitochondrial dysfunction in human alveolar epithelial cells].

PPARGC1A SIRT1

7.54e-06296232967762
Pubmed

Protocadherin 11X/Y a human-specific gene pair: an immunohistochemical survey of fetal and adult brains.

PCDH11Y PCDH11X

7.54e-06296222744706
Pubmed

[Effect of pure total flavonoids from citrus on hepatic SIRT1/PGC-1alpha pathway in mice with NASH].

PPARGC1A SIRT1

7.54e-06296224754177
Pubmed

Ampelopsin attenuates the atrophy of skeletal muscle from d-gal-induced aging rats through activating AMPK/SIRT1/PGC-1α signaling cascade.

PPARGC1A SIRT1

7.54e-06296228364603
Pubmed

SIRT1/PGC1α-Dependent Increase in Oxidative Phosphorylation Supports Chemotherapy Resistance of Colon Cancer.

PPARGC1A SIRT1

7.54e-06296225779952
Pubmed

SIRT1 Protects Dopaminergic Neurons in Parkinson's Disease Models via PGC-1α-Mediated Mitochondrial Biogenesis.

PPARGC1A SIRT1

7.54e-06296234251648
Pubmed

Elucidation of SIRT-1/PGC-1α-associated mitochondrial dysfunction and autophagy in nonalcoholic fatty liver disease.

PPARGC1A SIRT1

7.54e-06296233902605
Pubmed

Sirtuin 1 Agonist Minimizes Injury and Improves the Immune Response Following Traumatic Shock.

PPARGC1A SIRT1

7.54e-06296226009827
Pubmed

Beneficial effects of omega-3 and vitamin E coadministration on gene expression of SIRT1 and PGC1α and serum antioxidant enzymes in patients with coronary artery disease.

PPARGC1A SIRT1

7.54e-06296227033026
Pubmed

Quantitative analysis of alternative transcripts of human PCDH11X/Y genes.

PCDH11Y PCDH11X

7.54e-06296219859901
Pubmed

Peroxisome proliferator-activated receptor gamma co-activator 1alpha (PGC-1alpha) and sirtuin 1 (SIRT1) reside in mitochondria: possible direct function in mitochondrial biogenesis.

PPARGC1A SIRT1

7.54e-06296220448046
Pubmed

E3 ligase HUWE1 promotes PDGF D-mediated osteoblastic differentiation of mesenchymal stem cells by effecting polyubiquitination of β-PDGFR.

PDGFD HUWE1

7.54e-06296235472332
Pubmed

Syntabulin-mediated anterograde transport of mitochondria along neuronal processes.

SYBU KIF5B

7.54e-06296216157705
Pubmed

Proteasome inhibitor induced SIRT1 deacetylates GLI2 to enhance hedgehog signaling activity and drug resistance in multiple myeloma.

GLI2 SIRT1

7.54e-06296231576013
Pubmed

SIRT1 regulates hepatic vldlr levels.

VLDLR SIRT1

7.54e-06296238807218
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

FRAS1 ABCA2 MYCBP2 SGSM2 TTLL4 PKD1 KBTBD11 AKAP13 HUWE1 REV3L SNAPC4 ANKHD1 NOTCH2

1.10e-051105961335748872
Pubmed

Searching the second hit in patients with inherited retinal dystrophies and monoallelic variants in ABCA4, USH2A and CEP290 by whole-gene targeted sequencing.

ABCA4 USH2A

2.26e-05396230190494
Pubmed

Inverse regulation of the cytosolic Ca²⁺ buffer parvalbumin and mitochondrial volume in muscle cells via SIRT1/PGC-1α axis.

PPARGC1A SIRT1

2.26e-05396223028640
Pubmed

MiR-132-3p activation aggravates renal ischemia-reperfusion injury by targeting Sirt1/PGC1alpha axis.

PPARGC1A SIRT1

2.26e-05396237433399
Pubmed

PCSK9 deficiency unmasks a sex- and tissue-specific subcellular distribution of the LDL and VLDL receptors in mice.

VLDLR PCSK9

2.26e-05396226323289
Pubmed

Oleic acid stimulates complete oxidation of fatty acids through protein kinase A-dependent activation of SIRT1-PGC1α complex.

PPARGC1A SIRT1

2.26e-05396223329830
Pubmed

miR-29b overexpression induces cochlear hair cell apoptosis through the regulation of SIRT1/PGC-1α signaling: Implications for age-related hearing loss.

PPARGC1A SIRT1

2.26e-05396227635430
Pubmed

[SIRT1/PGC-1: a neuroprotective axis?].

PPARGC1A SIRT1

2.26e-05396217937892
Pubmed

Nuclear Perilipin 5 integrates lipid droplet lipolysis with PGC-1α/SIRT1-dependent transcriptional regulation of mitochondrial function.

PPARGC1A SIRT1

2.26e-05396227554864
Pubmed

AMACO is a component of the basement membrane-associated Fraser complex.

FRAS1 VWA2

2.26e-05396224232570
Pubmed

Faster lipid β-oxidation rate by acetyl-CoA carboxylase 2 inhibition alleviates high-glucose-induced insulin resistance via SIRT1/PGC-1α in human podocytes.

PPARGC1A SIRT1

2.26e-05396233957017
Pubmed

Computational and experimental insights into the circadian effects of SIRT1.

PPARGC1A SIRT1

2.26e-05396230348778
Pubmed

Distribution of the auxiliary GABAB receptor subunits KCTD8, 12, 12b, and 16 in the mouse brain.

KCTD16 KCTD8

2.26e-05396221452234
Pubmed

CD38 deficiency promotes skeletal muscle and brown adipose tissue energy expenditure through activating NAD+-Sirt1-PGC1α signaling pathway.

PPARGC1A SIRT1

2.26e-05396237192549
Pubmed

Evidence for a common mechanism of SIRT1 regulation by allosteric activators.

PPARGC1A SIRT1

2.26e-05396223471411
Pubmed

Activation of type 2 cannabinoid receptors (CB2R) promotes fatty acid oxidation through the SIRT1/PGC-1α pathway.

PPARGC1A SIRT1

2.26e-05396223747418
Pubmed

Cadherin expression in the somatosensory cortex: evidence for a combinatorial molecular code at the single-cell level.

PCDH11Y PCDH11X

2.26e-05396221129452
Pubmed

The influence of ethnicity in the association of WC, WHR, hypertension and PGC-1α (Gly482Ser), UCP2 -866 G/A and SIRT1 -1400 T/C polymorphisms with T2D in the population of Punjab.

PPARGC1A SIRT1

2.26e-05396225773007
Pubmed

Sirtuin 1 (SIRT1) deacetylase activity is not required for mitochondrial biogenesis or peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) deacetylation following endurance exercise.

PPARGC1A SIRT1

2.26e-05396221757760
Pubmed

Resveratrol induces expression of the slow, oxidative phenotype in mdx mouse muscle together with enhanced activity of the SIRT1-PGC-1α axis.

PPARGC1A SIRT1

2.26e-05396224760981
Pubmed

KCTD8 and KCTD12 Facilitate Axonal Expression of GABAB Receptors in Habenula Cholinergic Neurons.

KCTD16 KCTD8

2.26e-05396235017224
Pubmed

Fenofibrate inhibits atrial metabolic remodelling in atrial fibrillation through PPAR-α/sirtuin 1/PGC-1α pathway.

PPARGC1A SIRT1

2.26e-05396226787506
Pubmed

Homocysteine causes dysfunction of chondrocytes and oxidative stress through repression of SIRT1/AMPK pathway: A possible link between hyperhomocysteinemia and osteoarthritis.

PPARGC1A SIRT1

2.26e-05396229413962
Pubmed

Galangin Reverses H2O2-Induced Dermal Fibroblast Senescence via SIRT1-PGC-1α/Nrf2 Signaling.

PPARGC1A SIRT1

2.26e-05396235163314
Pubmed

Analysis of exome-sequenced UK Biobank subjects implicates genes affecting risk of hyperlipidaemia.

HUWE1 PCSK9

2.26e-05396232747172
Pubmed

Where and what is the right shift factor or cerebral dominance gene? A critique of Francks et al. (2007).

PCDH11Y PCDH11X

2.26e-05396219125366
Pubmed

Energy sensing factors PGC-1α and SIRT1 modulate PXR expression and function.

PPARGC1A SIRT1

2.26e-05396221933665
Pubmed

The metabolic sensors FXRα, PGC-1α, and SIRT1 cooperatively regulate hepatitis B virus transcription.

PPARGC1A SIRT1

2.26e-05396224297698
Pubmed

Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle.

PRKAG3 SIRT1

2.26e-05396220197054
Pubmed

A novel dipeptide from potato protein hydrolysate augments the effects of exercise training against high-fat diet-induced damages in senescence-accelerated mouse-prone 8 by boosting pAMPK / SIRT1/ PGC-1α/ pFOXO3 pathway.

PPARGC1A SIRT1

2.26e-05396232335547
Pubmed

The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2.

VLDLR PCSK9

2.26e-05396218039658
Pubmed

Non-clustered protocadherin.

PCDH11Y PCDH11X

2.26e-05396221173574
Pubmed

Valproate-induced murine autism spectrum disorder is associated with dysfunction of amygdala parvalbumin interneurons and downregulation of AMPK/SIRT1/PGC1α signaling.

PPARGC1A SIRT1

2.26e-05396237184727
Pubmed

Effect of DEHP and DnOP on mitochondrial damage and related pathways of Nrf2 and SIRT1/PGC-1α in HepG2 cells.

PPARGC1A SIRT1

2.26e-05396234822940
Pubmed

Genetic study between SIRT1, PPARD, PGC-1alpha genes and Alzheimer's disease.

PPARGC1A SIRT1

2.26e-05396218438697
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

MYCBP2 SSX2IP BACH1 KCTD8 AKAP13 MPHOSPH9 KIF5B PABIR2 NOTCH2 WDR62 PHLDB2

2.61e-05861961136931259
Pubmed

A Designed Peptide Targets Two Types of Modifications of p53 with Anti-cancer Activity.

MDM2 SIRT1

4.51e-05496229681526
Pubmed

ADAM17 mediates ectodomain shedding of the soluble VLDL receptor fragment in the retinal epithelium.

VLDLR ABCA4

4.51e-05496234509473
Pubmed

Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca(2+) and AMPK/SIRT1.

PPARGC1A SIRT1

4.51e-05496220357764
Pubmed

Panel-based NGS Reveals Novel Pathogenic Mutations in Autosomal Recessive Retinitis Pigmentosa.

ABCA4 USH2A

4.51e-05496226806561
Pubmed

Circulating proprotein convertase subtilisin/kexin 9 (PCSK9) regulates VLDLR protein and triglyceride accumulation in visceral adipose tissue.

VLDLR PCSK9

4.51e-05496221273557
Pubmed

Metabolic stress modulates Alzheimer's β-secretase gene transcription via SIRT1-PPARγ-PGC-1 in neurons.

PPARGC1A SIRT1

4.51e-05496223663737
Pubmed

Mdm2-p53-SF1 pathway in ovarian granulosa cells directs ovulation and fertilization by conditioning oocyte quality.

AMHR2 MDM2

4.51e-05496230260703
Pubmed

Adiponectin promotes pancreatic cancer progression by inhibiting apoptosis via the activation of AMPK/Sirt1/PGC-1α signaling.

PPARGC1A SIRT1

4.51e-05496225051362
Pubmed

Dynamic partnership between TFIIH, PGC-1α and SIRT1 is impaired in trichothiodystrophy.

PPARGC1A SIRT1

4.51e-05496225340339
Pubmed

Fibroblast Growth Factor 21 (FGF21) Promotes Formation of Aerobic Myofibers via the FGF21-SIRT1-AMPK-PGC1α Pathway.

PPARGC1A SIRT1

4.51e-05496227966786
Pubmed

Identification of a new gene mutated in Fraser syndrome and mouse myelencephalic blebs.

FRAS1 UMOD

4.51e-05496215838507
Pubmed

Thyroid hormone activation by type 2 deiodinase mediates exercise-induced peroxisome proliferator-activated receptor-γ coactivator-1α expression in skeletal muscle.

MYF5 PPARGC1A

4.51e-05496227302464
InteractionSLIT1 interactions

TRIM67 KRTAP13-2 KRTAP13-3 KRTAP1-1 KRTAP10-8

5.91e-0823935int:SLIT1
InteractionKRTAP4-5 interactions

KRTAP13-2 KRTAP1-5 KRTAP1-1 KRTAP1-3 LCE1F KRTAP10-8 PEAR1

5.98e-0876937int:KRTAP4-5
InteractionFEZF1 interactions

KRT40 KRTAP1-1 LRP2 SIRT1 KRTAP10-8

1.70e-0728935int:FEZF1
InteractionZNF408 interactions

VLDLR FRAS1 KRT40 KRTAP1-1 SSX2IP LRP2 NOTCH2 KRTAP10-8

3.60e-07145938int:ZNF408
InteractionKRTAP9-2 interactions

KRTAP13-2 KRTAP13-3 KRTAP1-5 KRTAP1-1 KRTAP1-3 KRTAP13-1 LCE1F KRTAP10-8

4.43e-07149938int:KRTAP9-2
InteractionGNE interactions

TRIM67 KRTAP13-2 KRTAP13-3 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-8

5.23e-07104937int:GNE
InteractionKRTAP5-11 interactions

KRTAP13-3 KRTAP1-5 KRTAP1-1 KRTAP1-3 LCE1F KRTAP10-8

5.96e-0766936int:KRTAP5-11
InteractionOTX1 interactions

KRTAP13-2 KRTAP13-3 KRTAP1-5 KRTAP1-1 KRTAP1-3 KRTAP13-1 LCE1F KRTAP10-8

5.98e-07155938int:OTX1
InteractionCHIC2 interactions

MYF5 KRT40 KRTAP1-1 KRTAP1-3 LCE1F KRTAP10-8

1.09e-0673936int:CHIC2
InteractionMAPKBP1 interactions

KRT40 KRTAP1-1 KRTAP1-3 KRTAP13-1 WDR62 KRTAP10-8

1.18e-0674936int:MAPKBP1
InteractionDYRK1A interactions

VLDLR ABCA2 TRIM67 MYCBP2 LRP2 CDK5RAP2 HUWE1 MDM2 ANKHD1 PABIR2 SIRT1 NOTCH2 WDR62

1.49e-065529313int:DYRK1A
InteractionTAPBPL interactions

TRIM67 KRT40 KRTAP1-1 KRTAP10-8

1.56e-0619934int:TAPBPL
InteractionKRTAP4-4 interactions

KRTAP13-2 KRTAP1-5 KRTAP1-1 KRTAP1-3 LCE1F KRTAP10-8

2.02e-0681936int:KRTAP4-4
InteractionCRH interactions

KRTAP1-5 KRTAP1-1 KRTAP1-3 KRTAP10-8

2.92e-0622934int:CRH
InteractionDMRT3 interactions

KRTAP1-5 KRT40 KRTAP1-1 KRTAP1-3 RUSC1 KRTAP10-8

3.07e-0687936int:DMRT3
InteractionCHRD interactions

KRTAP1-1 KRTAP1-3 KRTAP13-1 F2R LCE1F KRTAP10-8

4.82e-0694936int:CHRD
InteractionKRTAP5-6 interactions

KRTAP13-3 KRTAP1-5 KRTAP1-1 KRTAP1-3 LCE1F KRTAP10-8

4.82e-0694936int:KRTAP5-6
InteractionMXI1 interactions

KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-8 PEAR1

5.44e-0655935int:MXI1
InteractionSHFL interactions

KRTAP1-5 KRT40 KRTAP1-1 KRTAP1-3 SSX2IP KRTAP10-8

5.78e-0697936int:SHFL
InteractionSLC23A1 interactions

KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-8

5.88e-0626934int:SLC23A1
InteractionKLHL38 interactions

KRTAP13-2 KRT40 KRTAP1-1 KRTAP1-3 KRTAP13-1 KRTAP10-8

6.51e-0699936int:KLHL38
InteractionLCE3E interactions

KRTAP1-5 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-8

8.39e-0660935int:LCE3E
InteractionKRTAP10-5 interactions

KRTAP13-2 KRTAP1-5 KRTAP1-1 KRTAP1-3 KRTAP13-1 LCE1F KRTAP10-8

9.32e-06160937int:KRTAP10-5
InteractionKRTAP5-4 interactions

KRTAP1-5 KRTAP1-1 KRTAP1-3 LCE1F KRTAP10-8

1.07e-0563935int:KRTAP5-4
InteractionCREB5 interactions

KRTAP1-5 KRT40 KRTAP1-1 KRTAP1-3 BACH1 LCE1F KRTAP10-8

1.09e-05164937int:CREB5
InteractionKRTAP10-11 interactions

KRTAP13-3 KRTAP1-1 KRTAP1-3 LCE1F KRTAP10-8

1.15e-0564935int:KRTAP10-11
InteractionKRTAP5-3 interactions

KRTAP1-5 KRTAP1-1 KRTAP1-3 LCE1F KRTAP10-8

1.34e-0566935int:KRTAP5-3
InteractionGLYAT interactions

KRTAP1-1 KRTAP1-3 KRTAP10-8

1.53e-0511933int:GLYAT
InteractionZNF696 interactions

KRT40 KRTAP1-1 KRTAP1-3 NOTCH2 KRTAP10-8

1.56e-0568935int:ZNF696
InteractionLCE1E interactions

KRTAP1-5 KRTAP1-1 KRTAP1-3 LCE1F KRTAP10-8

1.56e-0568935int:LCE1E
InteractionLCE2A interactions

KRTAP1-5 KRTAP1-1 KRTAP1-3 LCE1F KRTAP10-8

1.67e-0569935int:LCE2A
InteractionHS6ST1 interactions

HS6ST3 KRTAP10-8 OPRM1 TMEM106A

1.77e-0534934int:HS6ST1
InteractionLCE1D interactions

KRTAP1-5 KRTAP1-1 KRTAP1-3 LCE1F KRTAP10-8

1.79e-0570935int:LCE1D
InteractionZNF417 interactions

MYF5 KRT40 KRTAP1-1 KRTAP1-3 SSX2IP NOTCH2 KRTAP10-8

1.86e-05178937int:ZNF417
InteractionWNT11 interactions

KRTAP1-5 KRTAP1-1 KRTAP1-3 KRTAP10-8

1.99e-0535934int:WNT11
InteractionHERC2 interactions

TRIM67 TRMT2A MYCBP2 PDGFD SSX2IP ARHGEF12 KIF5B MDM2 SIRT1 WDR62 FBXL5

2.02e-055039311int:HERC2
InteractionLCE2D interactions

KRTAP1-5 KRTAP1-1 KRTAP1-3 LCE1F KRTAP10-8

2.35e-0574935int:LCE2D
InteractionHOXB9 interactions

KRTAP1-5 KRT40 KRTAP1-1 KRTAP1-3 SIRT1 KRTAP10-8

2.37e-05124936int:HOXB9
InteractionIGFL3 interactions

VLDLR FRAS1 MYCBP2 LRP2 NOTCH2

2.51e-0575935int:IGFL3
InteractionSMCP interactions

KRTAP1-5 KRTAP1-1 KRTAP1-3 LCE1F KRTAP10-8

3.23e-0579935int:SMCP
InteractionLCE4A interactions

KRTAP1-5 KRTAP1-1 KRTAP1-3 LCE1F KRTAP10-8

3.43e-0580935int:LCE4A
InteractionAGPS interactions

TRIM67 CDK5RAP2 MPHOSPH9 HUWE1 SNAPC4 MDM2 SIRT1

3.46e-05196937int:AGPS
InteractionLCE2B interactions

KRTAP1-5 KRTAP1-1 KRTAP1-3 LCE1F KRTAP10-8

3.65e-0581935int:LCE2B
InteractionZNF587 interactions

MYF5 KRT40 KRTAP1-1 KRTAP1-3 SSX2IP KRTAP10-8

3.82e-05135936int:ZNF587
InteractionHOXA1 interactions

KRTAP13-4 KRTAP13-2 KRTAP13-3 KRTAP1-5 KRT40 KRTAP1-1 KRTAP1-3 LCE1F KRTAP10-8

3.95e-05356939int:HOXA1
InteractionPOU4F2 interactions

KRTAP13-3 KRTAP1-1 KRTAP13-1 LCE1F KRTAP10-8

4.10e-0583935int:POU4F2
InteractionC10orf62 interactions

KRT40 KRTAP1-1 KRTAP10-8

4.16e-0515933int:C10orf62
InteractionADAMTSL3 interactions

KRT40 KRTAP1-1 KRTAP10-8

4.16e-0515933int:ADAMTSL3
InteractionLCE1A interactions

KRTAP1-5 KRTAP1-1 KRTAP1-3 LCE1F KRTAP10-8

4.35e-0584935int:LCE1A
InteractionLCE1B interactions

KRTAP1-5 KRTAP1-1 KRTAP1-3 LCE1F KRTAP10-8

4.60e-0585935int:LCE1B
InteractionKRTAP9-3 interactions

KRTAP13-3 KRTAP1-1 KRTAP1-3 KRTAP13-1 LCE1F KRTAP10-8

4.69e-05140936int:KRTAP9-3
InteractionZNF497 interactions

KRTAP1-1 KRTAP1-3 NOTCH2 KRTAP10-8

5.01e-0544934int:ZNF497
InteractionTUBB4B interactions

TRIM67 TRMT2A MYCBP2 TCP11L1 SSX2IP FGD5 MPHOSPH9 HUWE1 ANKHD1 VCAM1 WDR62

5.37e-055609311int:TUBB4B
InteractionLCE2C interactions

KRTAP1-5 KRTAP1-1 KRTAP1-3 LCE1F KRTAP10-8

5.44e-0588935int:LCE2C
InteractionGUCD1 interactions

KRTAP13-3 KRTAP1-5 KRT40 KRTAP1-1 KRTAP10-8

5.44e-0588935int:GUCD1
InteractionINHBE interactions

FRAS1 MYCBP2 NOTCH2 PCSK9

5.48e-0545934int:INHBE
InteractionASAH1 interactions

TRIM67 TRMT2A CAMK1D KIF5B AAGAB

5.74e-0589935int:ASAH1
InteractionKRTAP12-3 interactions

KRTAP13-2 KRTAP13-3 KRTAP1-1 KRTAP13-1 LCE1F KRTAP10-8

5.92e-05146936int:KRTAP12-3
InteractionLCE3B interactions

KRTAP1-1 KRTAP1-3 LCE1F KRTAP10-8

5.98e-0546934int:LCE3B
InteractionLCE5A interactions

KRTAP1-5 KRTAP1-1 KRTAP1-3 LCE1F KRTAP10-8

6.06e-0590935int:LCE5A
InteractionITGB5 interactions

TRIM67 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-8 TMEM106A

6.15e-05147936int:ITGB5
InteractionLCE1F interactions

KRTAP1-5 KRTAP1-1 KRTAP1-3 LCE1F KRTAP10-8

6.73e-0592935int:LCE1F
InteractionKRTAP4-11 interactions

KRTAP1-5 KRTAP1-1 KRTAP1-3 LCE1F KRTAP10-8

6.73e-0592935int:KRTAP4-11
InteractionKRTAP10-1 interactions

KRTAP13-3 KRTAP1-5 KRTAP1-1 KRTAP1-3 LCE1F KRTAP10-8

7.68e-05153936int:KRTAP10-1
InteractionARHGEF18 interactions

TRIM67 ARHGEF12 AKAP13 HUWE1

7.68e-0549934int:ARHGEF18
InteractionSTK16 interactions

RPIA KRTAP13-2 KRTAP1-1 KRTAP1-3 KRTAP13-1 KRTAP10-8

8.25e-05155936int:STK16
InteractionPRF1 interactions

KRTAP1-1 KRTAP1-3 KRTAP10-8 TMEM106A

9.00e-0551934int:PRF1
InteractionNECTIN2 interactions

TRIM67 KRTAP1-1 KRTAP1-3 LCE1F KRTAP10-8 TMEM106A

9.50e-05159936int:NECTIN2
InteractionUBR3 interactions

AMHR2 TRIM67 CAMK1D DUSP1 PLA2G1B

9.54e-0599935int:UBR3
InteractionKRTAP9-8 interactions

KRTAP1-1 KRTAP1-3 KRTAP13-1 LCE1F KRTAP10-8

1.00e-04100935int:KRTAP9-8
InteractionZNF786 interactions

KRTAP1-1 KRTAP1-3 KRTAP10-8

1.19e-0421933int:ZNF786
InteractionGARIN6 interactions

KRT40 KRTAP1-1 KRTAP10-8

1.19e-0421933int:GARIN6
InteractionJOSD1 interactions

KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-8

1.30e-0456934int:JOSD1
InteractionFAH interactions

TRIM67 KRTAP13-3 KRTAP10-8

1.58e-0423933int:FAH
InteractionCHRNG interactions

KRTAP1-1 KRTAP1-3 KRTAP10-8

1.58e-0423933int:CHRNG
InteractionIL10 interactions

KRTAP1-3 LRP2 KRTAP10-8

1.58e-0423933int:IL10
InteractionZNF124 interactions

KRT40 KRTAP1-1 SSX2IP KRTAP10-8

1.59e-0459934int:ZNF124
InteractionTBP interactions

GLI2 SSX2IP HUWE1 SNAPC4 MDM2 AAGAB WDR62

1.71e-04253937int:TBP
InteractionNTN5 interactions

FRAS1 LRP2 NOTCH2

1.79e-0424933int:NTN5
InteractionZNF414 interactions

KRTAP13-3 KRTAP1-1 KRTAP1-3 ANKHD1 KRTAP10-8

1.85e-04114935int:ZNF414
InteractionVWC2 interactions

KRTAP13-2 KRTAP13-3 LCE1F KRTAP10-8

1.93e-0462934int:VWC2
InteractionKRT8 interactions

KRT40 SSX2IP PKD1 ARHGEF12 CDK5RAP2 FGD5 MPHOSPH9 VCAM1 WDR62

2.01e-04441939int:KRT8
InteractionZDHHC1 interactions

KRTAP1-1 KRTAP1-3 KRTAP10-8

2.03e-0425933int:ZDHHC1
InteractionNR1D1 interactions

MYCBP2 BACH1 HUWE1

2.03e-0425933int:NR1D1
InteractionKRTAP12-1 interactions

KRTAP1-1 KRTAP1-3 LCE1F KRTAP10-8

2.06e-0463934int:KRTAP12-1
InteractionPCDH11Y interactions

PCDH11Y PCDH11X

2.09e-045932int:PCDH11Y
InteractionTCAF1 interactions

TRIM67 KRTAP13-2 KRTAP1-3 HUWE1 KRTAP10-8

2.09e-04117935int:TCAF1
InteractionOIT3 interactions

TRMT2A MYCBP2 TNFRSF6B LCE1F

2.32e-0465934int:OIT3
InteractionPHLDA1 interactions

KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-8

2.46e-0466934int:PHLDA1
InteractionDOCK2 interactions

KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-8

2.46e-0466934int:DOCK2
InteractionZNF319 interactions

KRTAP13-3 KRT40 KRTAP10-8

2.57e-0427933int:ZNF319
InteractionZNF439 interactions

KRT40 KRTAP1-1 KRTAP10-8

2.57e-0427933int:ZNF439
InteractionZNF575 interactions

MYF5 KRT40 KRTAP10-8

2.57e-0427933int:ZNF575
InteractionLRFN4 interactions

KRTAP1-1 KRTAP1-3 KRTAP10-8 TMEM106A

2.61e-0467934int:LRFN4
InteractionHSPA12B interactions

KRT40 KRTAP1-1 WDR62 KRTAP10-8

2.61e-0467934int:HSPA12B
InteractionLCE3C interactions

KRTAP1-1 KRTAP1-3 LCE1F KRTAP10-8

2.61e-0467934int:LCE3C
InteractionNR1D2 interactions

KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-8

2.61e-0467934int:NR1D2
InteractionALPP interactions

KRTAP1-1 KRTAP1-3 LCE1F PCSK9 KRTAP10-8

2.64e-04123935int:ALPP
InteractionCRY2 interactions

MYCBP2 KRT40 KRTAP1-1 KRTAP1-3 HUWE1 KRTAP10-8

2.80e-04194936int:CRY2
InteractionHOXC8 interactions

KRTAP13-3 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-8

2.85e-04125935int:HOXC8
Cytoband21q22.1

KRTAP13-4 KRTAP13-2 KRTAP13-3 KRTAP13-1

1.40e-063996421q22.1
CytobandEnsembl 112 genes in cytogenetic band chr17q21

KRTAP1-5 KRT40 KRTAP1-1 KRTAP1-3 KRTAP16-1 TMEM106A

4.91e-04473966chr17q21
CytobandEnsembl 112 genes in cytogenetic band chr21q22

KRTAP13-4 KRTAP13-2 KRTAP13-3 KRTAP13-1 KRTAP10-8

1.21e-03377965chr21q22
Cytoband17q12-q21

KRTAP1-5 KRTAP1-3

2.06e-033296217q12-q21
GeneFamilyKeratin associated proteins

KRTAP13-4 KRTAP13-2 KRTAP13-3 KRTAP1-5 KRTAP1-1 KRTAP1-3 KRTAP13-1 KRTAP16-1 KRTAP10-8

1.81e-10109659619
GeneFamilyNon-clustered protocadherins

PCDH11Y PCDH11X

8.21e-041265221
GeneFamilyLow density lipoprotein receptors

VLDLR LRP2

9.68e-0413652634
GeneFamilyATP binding cassette subfamily A

ABCA2 ABCA4

1.13e-0314652805
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

ARHGEF12 AKAP13 FGD5

1.73e-0366653722
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ Genital tubercle F_emap-6706_k-means-cluster#1_top-relative-expression-ranked_1000

PPARGC1A SLITRK2 CAMK4 GLI2 HUWE1 PTGER3 PLEKHA8

1.25e-05193857gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle F_1000_k1
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PPARGC1A FRAS1 SLITRK2 ABCA4 PCDH11X LRP2 MUC5B USH2A

6.55e-091849682cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PPARGC1A FRAS1 SLITRK2 ABCA4 PCDH11X LRP2 MUC5B USH2A

6.55e-09184968ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PPARGC1A FRAS1 SLITRK2 ABCA4 PCDH11X LRP2 MUC5B USH2A

6.55e-091849682b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellBiopsy_IPF-Mesenchymal-Mesothelial_cells|Biopsy_IPF / Sample group, Lineage and Cell type

FRAS1 SLITRK2 PDGFD LRP2 PTGER3 SVEP1 VCAM1 PHLDB2

1.26e-08200968553386523fd8f8f36617a0d81032224b7ddce442
ToppCellTCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma-6|TCGA-Skin / Sample_Type by Project: Shred V9

KRTAP1-5 KRT40 KRTAP1-1 KRTAP1-3 KRTAP13-1 KRTAP16-1 KRTAP10-8

3.07e-08146967522c32103c24fc26836bb5b642083904682d9292
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KRT40 KRTAP1-1 PCDH11Y KRTAP1-3 PCDH11X F2R VWA2

9.45e-08172967cecfe5cf20f317ea01b4604789e07a14481c4cd6
ToppCellTCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Papillary_Muscle_Invasive_Urothelial_Carcinoma-10|TCGA-Bladder / Sample_Type by Project: Shred V9

KRTAP13-4 KRTAP13-3 KRTAP1-5 KRTAP1-3 CCL13 KRTAP13-1

3.71e-071299666a201c6344a015e5cf2f79ccf397fd7ad66b6768
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2-Exc_L6_FEZF2_KRT17|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KRT40 KRTAP1-1 PCDH11Y KRTAP1-3 PCDH11X F2R

1.86e-0617096684d49a1f2989d98bd0acf9ec2d59f1042fc0f55b
ToppCellCOVID-19-kidney-Distal_Epi_Doublet_(PCT)|COVID-19 / Disease (COVID-19 only), tissue and cell type

PPARGC1A FRAS1 KCTD8 LRP2 UMOD PTGER3

2.77e-061829669d67717a6e13bcb54c1297a3e4e3abf4e51628a3
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYCBP2 KIF5B HUWE1 REV3L PHLDB2 PCSK9

4.11e-061959663e519cffa6144a62b06124642a14c9ff39b76554
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYCBP2 KIF5B HUWE1 REV3L PHLDB2 PCSK9

4.11e-061959667796ea9247f4c63762f0de8490fed08b9717fa23
ToppCellMacroglial-Polydendrocytes-PDGFRA-|Macroglial / cells hierarchy compared to all cells using T-Statistic

PPARGC1A KCND2 KCTD16 PCDH11Y PCDH11X HS6ST3

4.76e-06200966f17b5a54e8f9eba9dcd0808ba4e8d275ac41bce2
ToppCellMacroglial-Polydendrocytes-PDGFRA--|Macroglial / cells hierarchy compared to all cells using T-Statistic

PPARGC1A KCND2 KCTD16 PCDH11Y PCDH11X HS6ST3

4.76e-06200966cc3409518f8b436ea92deb955e81114b3f410ff7
ToppCellMacroglial-Polydendrocytes-PDGFRA|Macroglial / cells hierarchy compared to all cells using T-Statistic

PPARGC1A KCND2 KCTD16 PCDH11Y PCDH11X HS6ST3

4.76e-06200966c24a3099e3d96d8b72f6d05286bb355d661a0377
ToppCellMacroglial-Polydendrocytes-PDGFRA---|Macroglial / cells hierarchy compared to all cells using T-Statistic

PPARGC1A KCND2 KCTD16 PCDH11Y PCDH11X HS6ST3

4.76e-062009664fc3de4bff7ed2bf40b38462c4b4e9b87af6a4ca
ToppCellMacroglial-Polydendrocytes-PDGFRA----L1-6|Macroglial / cells hierarchy compared to all cells using T-Statistic

PPARGC1A KCND2 KCTD16 PCDH11Y PCDH11X HS6ST3

4.76e-06200966310cd53db1c137f6af74e6ae682221d7ac27310c
ToppCellMacroglial-Polydendrocytes|Macroglial / cells hierarchy compared to all cells using T-Statistic

PPARGC1A KCND2 KCTD16 PCDH11Y PCDH11X HS6ST3

4.76e-06200966961858738ce35db8760c8c2e136f8369bc444ccf
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FRAS1 LRP2 MUC5B USH2A SVEP1

2.52e-05160965c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FRAS1 LRP2 MUC5B USH2A SVEP1

2.52e-0516096525c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell343B-Epithelial_cells-Epithelial-A_(AT2)-|343B / Donor, Lineage, Cell class and subclass (all cells)

WWC3 LRP2 PLA2G1B AKAP13 PCSK9

2.83e-05164965beaa13a75c3bb72446c85084d75e9fe3f15fd3d4
ToppCell343B-Epithelial_cells-Epithelial-A_(AT2)|343B / Donor, Lineage, Cell class and subclass (all cells)

WWC3 LRP2 PLA2G1B AKAP13 PCSK9

2.83e-05164965d005cfd821b87548b075120bffe65a0be9860463
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2-Exc_L6_FEZF2_KRT17|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KRT40 KRTAP1-1 KRTAP1-3 SHB F2R

3.00e-05166965739dfbe927f409821ff23aca6e47ebe78f57e859
ToppCellEndothelial-B-Donor_04|World / lung cells shred on cell class, cell subclass, sample id

ROBO4 ABCA4 PCDH11X KBTBD11 PEAR1

3.09e-051679656a03d16165e0b003092c39972928981abd4a75aa
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KRT40 KRTAP1-1 KRTAP1-3 PCDH11X F2R

3.09e-05167965a6ff7a3d9b80839c0efa91658836812e868561fa
ToppCellP15-Epithelial-airway_epithelial_cell-ciliated_cell_of_airway|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PRKAG3 AMHR2 FRAS1 TTLL4 TMEM106A

3.09e-051679655c3d0763f73628c71c71f9883556bb4f1639f3cc
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2-Exc_L6_FEZF2_KRT17|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KRTAP1-1 PCDH11Y KRTAP1-3 PCDH11X F2R

3.55e-05172965adc09c4d1b63fe84150516beb692db1e7f7ac980
ToppCellTCGA-Bone_and_Soft_Tissue-Primary_Tumor-Sarcoma-Dedifferentiated_Liposarcoma|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9

PDGFD KBTBD11 FGD5 MDM2 SVEP1

3.86e-051759652eca4c168dea2017ea0e383006e28abed22f32ec
ToppCellTCGA-Bone_and_Soft_Tissue-Primary_Tumor-Sarcoma-Dedifferentiated_Liposarcoma-4|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9

PDGFD KBTBD11 FGD5 MDM2 SVEP1

3.86e-0517596516849ea8f0985108baa2085f34c3de14a4f9f28b
ToppCell3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ABCA2 CAMK1D TTLL4 MUC5B PLEKHA8

4.07e-05177965a235ff4f37a7622216526191efc4832fb8ed6957
ToppCellLPS-antiTNF-Epithelial_alveolar-Mes-like-AT1_Progenitor|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

VLDLR SLITRK2 SHB F2R SVEP1

4.07e-05177965164ffbbf798defa3728197deb1a14b661490e525
ToppCell390C-Fibroblasts-Fibroblast-G|390C / Donor, Lineage, Cell class and subclass (all cells)

FRAS1 SLITRK2 GLI2 KCTD16 SVEP1

4.41e-05180965137fc14859c89e1ecd98bee388bb58c04b835847
ToppCellfacs-Lung-24m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l49|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

VLDLR AMHR2 GGNBP2 F2R HS6ST3

4.41e-05180965e9785ac2806103f725f5a5208495826354ec6e22
ToppCell390C-Fibroblasts-Fibroblast-G-|390C / Donor, Lineage, Cell class and subclass (all cells)

FRAS1 SLITRK2 GLI2 KCTD16 SVEP1

4.41e-05180965cd6790de050151fedfa2c5ea6ad58b72665414b2
ToppCell5'-Adult-LargeIntestine-Mesenchymal-mesothelial_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FRAS1 LRP2 PTGER3 VCAM1 PHLDB2

4.53e-0518196565eaa9bc1022bcf0c5f0f92c07a2cbbf11f9b59c
ToppCell5'-Adult-LargeIntestine-Mesenchymal-mesothelial_cell-Mesothelium_(PRG4+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FRAS1 LRP2 PTGER3 VCAM1 PHLDB2

4.53e-05181965eaac7d58117eddfff06b25521efc431c1351d592
ToppCelldroplet-Liver-Npc-21m-Endothelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ROBO4 PDGFD FGD5 F2R PEAR1

4.65e-05182965dc55de945c6f78f32eb3a1b3520835eb8417e068
ToppCelldroplet-Marrow-nan-3m-Hematologic-nan|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYCBP2 CAMK4 DUSP1 KBTBD11 F2R

4.65e-05182965e78ba2c5cae480c16a596ce7c3bf2d480becacf4
ToppCelldroplet-Marrow-nan-3m-Hematologic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYCBP2 CAMK4 DUSP1 KBTBD11 F2R

4.65e-051829651710eab3037a87609d21838be2d2d29c3bc36651
ToppCelldroplet-Liver-Npc-21m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ROBO4 PDGFD FGD5 F2R PEAR1

4.65e-05182965010a7364da46101cb5068891fd7bc712ea8f13bd
ToppCelldroplet-Liver-Npc-21m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ROBO4 PDGFD FGD5 F2R PEAR1

4.65e-05182965b1ec2015aad1181eac1bbf8d48ad6f2f7ed24a01
ToppCelldroplet-Lung-nan-18m-Mesenchymal-pulmonary_interstitial_fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYF5 TRIM67 KCTD16 PCDH11X SYBU

5.16e-05186965b58db5abdd3e9f0214b198c3cbd09b0b3c321eab
ToppCelldroplet-Liver-Hepatocytes-24m-Endothelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ROBO4 PDGFD FGD5 PHLDB2 PEAR1

5.16e-051869652cae34336f184f971f7c8684cc27c23a4e7369ed
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PPARGC1A MTSS1 PTGER3 HS6ST3 PLEKHA8

5.16e-05186965a6ef5d5944af5689b5f27bef89cd05645eedbe50
ToppCelldroplet-Lung-nan-18m-Mesenchymal-Myofibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYF5 TRIM67 KCTD16 PCDH11X SYBU

5.16e-05186965cd6502bbf9dce318fdbb4965d49df8951e5f795c
ToppCelldroplet-Liver-Hepatocytes-24m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ROBO4 PDGFD FGD5 PHLDB2 PEAR1

5.16e-0518696590d53c2597a9f3a2b39afba75adfc54f1ca0a4db
ToppCelldroplet-Lung-18m-Mesenchymal-myofibroblast-myofibroblast_cell-pulmonary_interstitial_myofibroblast|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MYF5 TRIM67 KCTD16 PCDH11X SYBU

5.29e-051879658bd635abdee5d5a12a3f7bf74eab4282e8e40741
ToppCelldroplet-Lung-18m-Mesenchymal-myofibroblast-myofibroblast_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MYF5 TRIM67 KCTD16 PCDH11X SYBU

5.29e-051879653cb8cd7f7a4306ff74d1f7f9964014008ec1c6a0
ToppCell(2)_5-FU-(1)_VE-Cad+_vascular_cells|(2)_5-FU / Stress and Cell class

ROBO4 DUSP1 FGD5 PEAR1 TMEM106A

5.56e-051899650f169b17bb26a812a5b0dcd6e29a3ca8415fd197
ToppCelldroplet-Liver-Hepatocytes-24m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ROBO4 PDGFD FGD5 PHLDB2 PEAR1

5.56e-05189965ce5b3d53c9a5457a5a02b221dee18334b5eaf8b7
ToppCellLPS-IL1RA-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

GLI2 PDGFD REV3L SVEP1 VCAM1

5.70e-0519096545df8fee00f8949937863159d7aa042e72748d9b
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PPARGC1A KCND2 TRPC5 BACH1 KCTD8

5.70e-051909658c9c230a509afaeee50644153974a5642b01a2b8
ToppCellCV-Moderate-0|Moderate / Virus stimulation, Condition and Cluster

DUSP1 MTSS1 AKAP13 F2R VCAM1

5.85e-051919656776bcc4c1915f0c1062002ff7746f20ceb725f4
ToppCell3'-GW_trimst-1.5-SmallIntestine-Mesenchymal-myocytic-myofibroblast_(RSPO2+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CAMK4 REV3L F2R SVEP1 VCAM1

5.85e-0519196589d03c4133dda852a3713c0902a7d67941cf5b21
ToppCellLPS-antiTNF-Endothelial-Endothelial-Activated_Alv_Cap|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FRAS1 MTSS1 ARHGEF12 FGD5 SYBU

5.99e-05192965c618ede75dce3988c87a5b8f98d8e94e1dd66efd
ToppCellLPS_only-Endothelial-Endothelial-Vein|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SHB TNFRSF6B FGD5 F2R VCAM1

5.99e-0519296552acaecd3703166f5ce3b328aff7c82bd142fee4
ToppCellLPS-antiTNF-Endothelial-Endothelial-Vein|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TNFRSF6B FGD5 F2R VWA2 VCAM1

5.99e-0519296581baf1c4063469bb0c03a8602b40e387ba7b0dfb
ToppCell(1)_Control_(PBS)-(1)_VE-Cad+_vascular_cells|(1)_Control_(PBS) / Stress and Cell class

ROBO4 FGD5 F2R PEAR1 TMEM106A

5.99e-05192965e16e49b302019474232ef4cc0ff217d33afe34cf
ToppCellCD8+_Memory_T_cell-CV-0|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster

DUSP1 MTSS1 AKAP13 F2R VCAM1

6.14e-05193965995781d87a919c0380750878bafe584342bb83ad
ToppCellfacs-Lung-EPCAM-3m-Mesenchymal-fibroblast_of_lung|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VLDLR F2R HS6ST3 SVEP1 VCAM1

6.14e-05193965027e098ad018e782287f84eee0f77551018f2196
ToppCellfacs-Lung-EPCAM-3m-Mesenchymal-Alveolar_Fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VLDLR F2R HS6ST3 SVEP1 VCAM1

6.14e-05193965c5463a87f20b3a7f7ffda677b2f5a0e9e49d6685
ToppCellLA|World / Chamber and Cluster_Paper

KCND2 GLI2 KCTD8 LRP2 SVEP1

6.14e-05193965d4bf89437216baf489ea0239136dcedf3b6714af
ToppCellLPS-IL1RA-Endothelial-Endothelial-Activated_Alv_Cap|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ROBO4 MTSS1 ARHGEF12 FGD5 SYBU

6.14e-05193965a3636c35ed25aabe2f1aba016c9fe125327bbfaf
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ROBO4 MTSS1 FGD5 F2R VCAM1

6.14e-051939651f978e102a029a6beb10913052cd0a20c7253e8e
ToppCellLPS-IL1RA+antiTNF-Endothelial-Endothelial-Vein|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TNFRSF6B FGD5 F2R VWA2 VCAM1

6.14e-051939657261c1ce30c796b61c6ec58e64a051baa24732ff
ToppCellfacs-Lung-nan-3m-Endothelial-endothelial_cell_of_lung|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ROBO4 PDGFD ARHGEF12 FGD5 PHLDB2

6.30e-05194965f159ef8541d75a4e98468947f231bb463bec922c
ToppCellIPF-Epithelial-Mesothelial|Epithelial / Disease state, Lineage and Cell class

PDGFD KCTD8 PTGER3 VCAM1 PHLDB2

6.30e-05194965d8a26da856a85e3d001d406e992cb18fdd58baef
ToppCell368C-Fibroblasts-Fibroblast-G-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

FRAS1 DUSP1 KCTD16 F2R SVEP1

6.30e-05194965d9eec28fa7b255c0ec023276dd955f1e276e7159
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibro-meso-mesothelial_cell-Mesothelium-Mesothelium_L.2.6.0.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PDGFD KCTD8 PTGER3 SVEP1 VCAM1

6.30e-05194965421344cc4b601d9745fa72d0af3124dab11d1d27
ToppCell368C-Fibroblasts-Fibroblast-G|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

FRAS1 DUSP1 KCTD16 F2R SVEP1

6.30e-05194965e4d7e9709ce42d4610e44d3445927eefbcbb9eff
ToppCellCV-Moderate-0|CV / Virus stimulation, Condition and Cluster

DUSP1 MTSS1 AKAP13 F2R VCAM1

6.30e-051949659ff69139dae007fcc349daefcb5021defb0e0d2a
ToppCell3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

WWC3 LRP2 PLA2G1B AKAP13 PCSK9

6.45e-051959656617abca0009ad3d8731f515f91ab275f9ea4c40
ToppCell3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

WWC3 LRP2 PLA2G1B AKAP13 PCSK9

6.45e-05195965fc0ae145a2118df7cbbc9ac4ca9dc12d26c087c4
ToppCellTracheal-NucSeq-Endothelial-Endothelia_lymphatic-Endothelia_Lymphatic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ROBO4 ABCA4 KBTBD11 FGD5 PEAR1

6.61e-0519696509a7edf4a7defb7fe70d9777dd9500ee8421ff31
ToppCellTracheal-NucSeq-Endothelial-Endothelia_lymphatic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ROBO4 ABCA4 KBTBD11 FGD5 PEAR1

6.61e-05196965e50d2c66d5c5cd25fdfecdcc4c8506a1d0a85755
ToppCellfacs-Diaphragm-Limb_Muscle-3m-Mesenchymal-skeletal_muscle_satellite_cell|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYF5 BACH1 F2R VCAM1 NOTCH2

6.61e-0519696597ac47daf5bb07fa5dda3976e1ae402750f959b5
ToppCellfacs-Liver-Non-hepatocytes-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ROBO4 FGD5 F2R PHLDB2 TMEM106A

6.77e-05197965deefb492b5f0e6014144bd465c4a6ae4206e8739
ToppCell10x3'2.3-week_17-19-Endothelial-stroma-sinusoidal_EC|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

ROBO4 FGD5 F2R PHLDB2 PEAR1

6.77e-051979654e58bbf3ecb30b4c8199adcc04d2eb134d90de56
ToppCellfacs-Liver-Non-hepatocytes-3m-Endothelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ROBO4 FGD5 F2R PHLDB2 TMEM106A

6.77e-05197965a6aaa6faea348291023f0bc4b0f83fbc67d91da6
ToppCellBronchial-10x5prime-Stromal-Mesofibroblastic-Mesothelia|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

VLDLR FRAS1 SLITRK2 PTGER3 VCAM1

6.77e-0519796526888af95a7cc082a1f1218af35b1f07cb9436ed
ToppCellBronchial-10x5prime-Stromal-Mesofibroblastic|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

VLDLR FRAS1 SLITRK2 PTGER3 VCAM1

6.77e-05197965438de7f0d35d81d5f5e41dcef7b2c54b6da03df4
ToppCellTracheal-NucSeq-Endothelial-Endothelia_vascular-VE_pulmonary_arterial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ROBO4 PDGFD PCDH11X FGD5 KIF25

6.93e-05198965f88198e11e835ad53d339c312f8f7b7b0b5c02d3
ToppCellfacs-Liver-Non-hepatocytes-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ROBO4 FGD5 F2R PHLDB2 TMEM106A

6.93e-05198965f0f1816a0ed3ae8207442602f5cbe4de0382e4b3
ToppCelldistal-1-mesenchymal-Mesothelial|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

FRAS1 SLITRK2 KCTD8 PTGER3 VCAM1

7.10e-051999658dd5b411d2f1626830b77a1616cc3fb67dc59338
ToppCellLPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

MYCBP2 PDGFD REV3L SVEP1 VCAM1

7.10e-05199965a7dd94b172c973a131a6792f8ccd9bfe44d984ac
ToppCellTracheal-NucSeq-Stromal-Peri/Epineurial_|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PDGFD MTSS1 SVEP1 PHLDB2 PEAR1

7.10e-051999653835452e4848d7f7dd8651c17b746b271ef39688
ToppCellBiopsy_Control_(H.)-Mesenchymal-Mesothelial_cells|Biopsy_Control_(H.) / Sample group, Lineage and Cell type

PDGFD KCTD8 PTGER3 SVEP1 VCAM1

7.10e-05199965ca970114b5aef4518ce580897a62ac88688b2671
ToppCellLPS_IL1RA-Epithelial_alveolar-AT_1|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

FRAS1 ABCA4 PCDH11X PLA2G1B PHLDB2

7.10e-05199965a270630626df614f8605abddb7dee7c4d74f6149
ToppCellNeuronal-Excitatory-eE(FEZF2_SLC17A7)|Neuronal / cells hierarchy compared to all cells using T-Statistic

KRT40 KRTAP1-3 SHB PCDH11X F2R

7.27e-05200965501cd2b4e55444fc5fdd93ebbcfc0616442b110b
ToppCellLPS_only-Endothelial-Endothelial-Activated_Gen_Cap|LPS_only / Treatment groups by lineage, cell group, cell type

ROBO4 SHB TNFRSF6B ARHGEF12 VCAM1

7.27e-052009656f531a418ff25b59a543800cf4bce7b72404ce08
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-Alv_Cap|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

ROBO4 MTSS1 ARHGEF12 FGD5 SYBU

7.27e-05200965b7533c571eeea0cb3678e1a57d3dc036fa8d0f49
ToppCellBronchial-NucSeq-Stromal-Fibroblastic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

KCND2 GLI2 KCTD16 SVEP1 PHLDB2

7.27e-05200965cae972324d1dfea6efeaf6013f265c7c6bb48db4
ToppCellNeuronal-Excitatory-eE(FEZF2_SLC17A7)-eE_1(EFTUD1P1)---L5-6|Neuronal / cells hierarchy compared to all cells using T-Statistic

KRT40 KRTAP1-1 KRTAP1-3 SHB F2R

7.27e-05200965046a3a4d7e4d84ee4252a695ffd4a6aee8b77070
ToppCellNeuronal-Excitatory-eE(FEZF2_SLC17A7)-eE_1(EFTUD1P1)-|Neuronal / cells hierarchy compared to all cells using T-Statistic

KRT40 KRTAP1-1 KRTAP1-3 SHB F2R

7.27e-05200965893cc7f6b9794da90aa0c9d721b8647dc97201cd
ToppCellNeuronal-Excitatory-eE(FEZF2_SLC17A7)-eE_1(EFTUD1P1)|Neuronal / cells hierarchy compared to all cells using T-Statistic

KRT40 KRTAP1-1 KRTAP1-3 SHB F2R

7.27e-052009653d677f13e429abc805a52ec2b8f36c703f511569
ToppCellKidney|World / Skin and Kidney Cells in Lupus Nephritis Patients.

PPARGC1A KBTBD11 LRP2 UMOD VCAM1

7.27e-052009651f99afa1f3c32a2a9cfb4ad33ff4d404e34fac63
ToppCellNeuronal-Excitatory-eE(FEZF2_SLC17A7)-eE_1(EFTUD1P1)--|Neuronal / cells hierarchy compared to all cells using T-Statistic

KRT40 KRTAP1-1 KRTAP1-3 SHB F2R

7.27e-0520096512518f4a8d01fc66b72878cdf0ba124b37cff3d8
ToppCelldroplet-Tongue-Unstain-18m-Epithelial-nan|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRTAP1-5 KRTAP1-3 KRTAP13-1 NOTCH2

1.96e-04133964f7d0763b5eec2db33044d6850fd57462494038c1
ToppCellControl-Fibroblasts-Mesothelial_FB|Control / group, cell type (main and fine annotations)

WDR87 KCTD8 PCDH11X VCAM1

2.33e-04139964e769beb031b262dd92c9605b07dbf3c29fb82520
ToppCellCOVID-19-Fibroblasts-Mesothelial_FB|COVID-19 / group, cell type (main and fine annotations)

FRAS1 KCTD8 PTGER3 USH2A

2.46e-041419647e6dcccb74e7ee90b69dc91b59491b84f3a713c9
ToppCellfacs-Large_Intestine-Proximal-3m-Epithelial-Goblet_cell,_top_of_crypt_(Distal)|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ROBO4 GLI2 UMOD KRTAP16-1

2.95e-04148964dfd3f2c4b884ea9e23831a242a89ac985b409640
DrugCinchonine [118-10-5]; Up 200; 13.6uM; MCF7; HT_HG-U133A

ABCA2 CAMK1D CAMK4 TCP11L1 LRP2 SYBU MDM2 SVEP1

1.55e-061949582789_UP
DrugDiflunisal [22494-42-4]; Up 200; 16uM; MCF7; HT_HG-U133A

CAMK4 TCP11L1 SSX2IP BACH1 ARHGEF12 MDM2 NOTCH2 WDR62

1.61e-061959584794_UP
Drugpenasterol

PLA2G1B F2R

1.72e-052952CID000164003
DrugAmikacin hydrate [37517-28-5]; Up 200; 6.6uM; PC3; HT_HG-U133A

ROBO4 VLDLR TCP11L1 LRP2 MPHOSPH9 SNAPC4 NOTCH2

1.83e-051969576715_UP
Druglysoplasmalogens

PLA2G1B F2R VCAM1

1.95e-0513953CID009546720
DrugIsoflupredone acetate [338-98-7]; Down 200; 9.6uM; MCF7; HT_HG-U133A

ZNF141 TNFRSF6B LRP2 AKAP13 F2R NOTCH2 WDR62

1.96e-051989575545_DN
DrugHarmane hydrochloride [21655-84-5]; Down 200; 18.2uM; PC3; HT_HG-U133A

ABCA2 GLI2 TCP11L1 DUSP1 ARHGEF12 CDK5RAP2 NOTCH2

1.96e-051989574584_DN
DrugBrompheniramine maleate [980-71-2]; Up 200; 9.2uM; MCF7; HT_HG-U133A

VLDLR CAMK1D LRP2 MDM2 F2R AAGAB SVEP1

2.02e-051999573271_UP
Drugbenzyloxycarbonylleucyl-leucyl-leucine aldehyde

ROBO4 PPARGC1A SWT1 BACH1 PKD1 KBTBD11 LRP2 SYBU MDM2 SIRT1 VCAM1

2.11e-055589511ctd:C072553
DiseaseSushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 measurement

SVEP1 PEAR1

5.26e-054882EFO_0803113
Diseaseage related macular degeneration (implicated_via_orthology)

PPARGC1A CCL13

1.31e-046882DOID:10871 (implicated_via_orthology)
Diseaseasparagine measurement

FRAS1 KCTD8 PTGER3

2.52e-0441883EFO_0009766
DiseaseCeroid lipofuscinosis, neuronal 1, infantile

PPARGC1A SIRT1

3.90e-0410882C2931673
Diseasemembranous glomerulonephritis (biomarker_via_orthology)

LRP2 PTGER3

7.82e-0414882DOID:10976 (biomarker_via_orthology)
DiseaseAutosomal recessive primary microcephaly

CDK5RAP2 WDR62

9.00e-0415882cv:C3711387
Diseaseatopic eczema

KCND2 DUSP1 KCTD8 TNFRSF6B LCE1F

9.61e-04252885EFO_0000274
Diseasebipolar disorder

CAMK1D PPDPF SYBU KIF5B HUWE1 ANKHD1 SVEP1

1.71e-03577887MONDO_0004985
Diseasetreatment resistant depression, response to antidepressant

KRTAP13-3 KRTAP13-1

1.78e-0321882EFO_0009854, GO_0036276
DiseaseLung Injury

PDGFD SIRT1

1.78e-0321882C0273115
DiseaseChronic Lung Injury

PDGFD SIRT1

1.78e-0321882C2350344
DiseaseAutosomal Recessive Primary Microcephaly

CDK5RAP2 WDR62

1.95e-0322882C3711387
DiseasePrimary microcephaly

CDK5RAP2 WDR62

1.95e-0322882C0431350
DiseaseHuntington's disease (is_implicated_in)

PPARGC1A SIRT1

2.14e-0323882DOID:12858 (is_implicated_in)
Diseasenephrotic syndrome (biomarker_via_orthology)

PPARGC1A VLDLR

2.33e-0324882DOID:1184 (biomarker_via_orthology)
Diseasemethionine measurement

SYBU ANKHD1

2.73e-0326882EFO_0009771
Diseasemacular degeneration (is_implicated_in)

PPARGC1A ABCA4

2.94e-0327882DOID:4448 (is_implicated_in)

Protein segments in the cluster

PeptideGeneStartEntry
CPFISTLSTEGCSSN

BACH1

461

O14867
TCSCSSKGFSTTCPA

ABCA4

1176

P78363
CLPSDCTASAAGSST

PRKAG3

116

Q9UGI9
PSTSDFCQTRSCISE

SSX2IP

541

Q9Y2D8
DALNVPSTCCFTFSS

CCL13

26

Q99616
SSSEETESTQCCPGS

AKAP13

331

Q12802
SPGSTLFTCSCGTDF

AMHR2

101

Q16671
SCFEIQSPSSCADSQ

ARHGEF12

1486

Q9NZN5
SCDSGSSATSTPCVS

CDK5RAP2

1696

Q96SN8
PGTSFNTTCSSCTCS

MUC5B

396

Q9HC84
SNSSCSSTECPGEAI

PPDPF

26

Q9H3Y8
CCSPSSYNESETKST

KIF5B

301

P33176
SCTPGSTCIDRVASF

NOTCH2

346

Q04721
SNCTDALAYSSCSPA

OPRM1

11

P35372
SESGTSCNELSTSSC

KCTD8

346

Q6ZWB6
GTCATSRCQTPSFLS

KRT40

36

Q6A162
STTCTSSNTCEPCSA

KRT40

406

Q6A162
QSCSEPTSPTSNCSD

MYF5

151

P13349
GPFSCSSCDTNLVLS

FRAS1

871

Q86XX4
GESGTSCNDLSTSSC

KCTD16

301

Q68DU8
IVTNENTSCTCPSSG

GGNBP2

431

Q9H3C7
VPSCSASSCSSVTAS

CAMK4

6

Q16566
TSPASSSDSSGSCPC

MESP2

31

Q0VG99
CSCRDTSATPQSASI

PDGFD

16

Q9GZP0
ASSDCSTCFVSQSGT

PCSK9

371

Q8NBP7
CSSGYSTQTTTPCCS

MTSS1

501

O43312
NYASSSTSLPCQCSS

PTGER3

366

P43115
RTGPSCDVSCSQGTS

PEAR1

211

Q5VY43
PTESTSFCSESCSPL

FGD5

351

Q6ZNL6
SFCSESCSPLSESAK

FGD5

356

Q6ZNL6
TSQPDCNVDSCSVSS

MPHOSPH9

31

Q99550
SPSLSSQQGVTSTCC

KCND2

516

Q9NZV8
TSFCGFPSCSTSGTC

KRTAP1-1

6

Q07627
TSFCGYPSCSTSGTC

KRTAP1-3

6

Q8IUG1
GFPSFSTSGTCSSSC

KRTAP1-3

46

Q8IUG1
GFPSFSTSGTCSSSC

KRTAP1-5

46

Q9BYS1
SGLCQSSPGAQSSCS

GLI2

651

P10070
GTLNNTCSSSAFTCG

LRP2

1061

P98164
LTQSGSDSSCSPECL

PLEKHA8

286

Q96JA3
CSSSSSDPYSVSDCG

PCDH11X

981

Q9BZA7
TTPSCGSCSRVSFAL

POM121L12

271

Q8N7R1
ACSPCSSQSSSSGIC

HUWE1

3371

Q7Z6Z7
VSPSCTSSCTNFGEQ

HS6ST3

26

Q8IZP7
GSATAESPVACSNSC

PABIR2

221

Q7Z309
ESPVACSNSCSSFIL

PABIR2

226

Q7Z309
LCCKESSDPSSYNSS

F2R

386

P25116
VSPSCSSFNSPCRDS

PPARGC1A

536

Q9UBK2
TSVPDSAESGCSSCS

DUSP1

151

P28562
SAESGCSSCSTPLYD

DUSP1

156

P28562
TCSAQGTGFSCPSSV

ABCA2

1641

Q9BZC7
SICSGASSPCCQQSS

KRTAP10-8

136

P60410
QSSDCCSQPSAGSSC

LCE1F

91

Q5T754
YSTDLCSPSTCQLGS

KRTAP13-1

36

Q8IUC0
YSTDLCSPSTCQLGS

KRTAP13-2

36

Q52LG2
YSTDLCSPSTCQLGS

KRTAP13-3

36

Q3SY46
PCQTTCSGSLGFRSS

KRTAP13-4

76

Q3LI77
FSVPATSLCSTEVSC

KRTAP16-1

11

A8MUX0
SNFSCSTSGCFSKDI

FBXL5

511

Q9UKA1
QPSSASFACLSLCSG

PKD1

236

P98161
ACDSISNCSSSSSDP

PCDH11Y

1006

Q9BZA8
CSGDSSISFSACFTQ

OR52I2

116

Q8NH67
GNTSTSCGDSNSICP

RPIA

56

P49247
GCSSSLSSCSDLSPD

RUSC1

101

Q9BVN2
TADASFVTCPTCQGS

TMEM106A

51

Q96A25
SCLSLCGSSPFTTDK

TCP11L1

406

Q9NUJ3
FTLTACTSAGCTSSE

USH2A

3656

O75445
CGQESSSALSCPTVS

TRMT2A

16

Q8IZ69
DSVSLTCSTTGCESP

VCAM1

41

P19320
ASASCGPATASCFSA

SHB

51

Q15464
CSDCQSPLSTSGFTS

TMCO2

166

Q7Z6W1
ASPGASASLTCTLCS

IGLV5-45

31

A0A087WSX0
CCERSSSSESTGTPS

MDM2

206

Q00987
PLCSQGSSCLSCSSS

SGSM2

451

O43147
PSSCVCTSQSSDNGL

SLITRK2

341

Q9H156
LSSSSCGSNSDSGTC

SIRT1

666

Q96EB6
CGSNSDSGTCQSPSL

SIRT1

671

Q96EB6
QCPDGVTFTFSTCSL

MYCBP2

1851

O75592
SYSCSGSAITCSSKN

PLA2G1B

96

P04054
CSDSTADQACSATLP

KIF25

211

Q9UIL4
TQSFEAPCCSVSSES

SWT1

321

Q5T5J6
SCGSLSQSSASFFTP

PHLDB2

521

Q86SQ0
FGSRSCLSCPENTST

SVEP1

1081

Q4LDE5
DCLAPSTLCSFISSS

CAMK1D

346

Q8IU85
AQTPCSLGASLCFSS

KBTBD11

31

O94819
LAQLSSPCSSSDSLC

ROBO4

611

Q8WZ75
PCALVTSCSSVFSGD

AAGAB

6

Q6PD74
LCTPSSTANSCSSSA

ANKHD1

2041

Q8IWZ3
ACSSLSSSSSSITCP

TRIM67

146

Q6ZTA4
NCSANSSCVNTPGSF

UMOD

76

P07911
FPSSFTENCELLSCS

REV3L

736

O60673
SNSFCSDDTGCPSSQ

SYBU

71

Q9NX95
TLSSSAICSSATPDC

VWA2

221

Q5GFL6
PFTCEECGSIFTTSS

ZNF141

226

Q15928
ACLPSGSFLTCSSDN

WDR62

421

O43379
PDSGKCSASSCLDTS

SNAPC4

1431

Q5SXM2
GAAQSSECPLACSSS

TRPC5

911

Q9UL62
FFCPSTLCSSGTTAV

TTLL4

81

Q14679
FTSTSSGSSITCCFT

WDR87

196

Q6ZQQ6
GRPLTASSEQTCCSS

WBP1

146

Q96G27
ASSEQTCCSSSSSCP

WBP1

151

Q96G27
DSVDSGCSNCTQTSP

WWC3

816

Q9ULE0
SSSHDTLCTSCTGFP

TNFRSF6B

186

O95407
NITCSPDEFTCSSGR

VLDLR

151

P98155