Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	MAP-kinase scaffold activity	SPAG9 MAPK8IP3	1.80e-04	13	31	2	GO:0005078
GeneOntologyMolecularFunction	JUN kinase binding	SPAG9 MAPK8IP3	3.13e-04	17	31	2	GO:0008432
GeneOntologyMolecularFunction	phospholipase binding	PLA2R1 BTK	1.12e-03	32	31	2	GO:0043274
GeneOntologyMolecularFunction	phosphatidylinositol-3,4,5-trisphosphate binding	IQGAP2 BTK	2.62e-03	49	31	2	GO:0005547
GeneOntologyMolecularFunction	signaling receptor complex adaptor activity	SPAG9 MAPK8IP3	3.17e-03	54	31	2	GO:0030159
GeneOntologyMolecularFunction	kinesin binding	SPAG9 MAPK8IP3	3.29e-03	55	31	2	GO:0019894
GeneOntologyMolecularFunction	phosphatidylinositol phosphate binding	OSBP IQGAP2 BTK	3.57e-03	199	31	3	GO:1901981
Domain	JIP_LZII	SPAG9 MAPK8IP3	2.67e-06	2	31	2	IPR032486
Domain	JIP_LZII	SPAG9 MAPK8IP3	2.67e-06	2	31	2	PF16471
Domain	Jnk-SapK_ap_N	SPAG9 MAPK8IP3	1.60e-05	4	31	2	PF09744
Domain	JNK/Rab-associated_protein-1_N	SPAG9 MAPK8IP3	1.60e-05	4	31	2	IPR019143
Domain	RH2	SPAG9 MAPK8IP3	2.66e-05	5	31	2	PS51777
Domain	RH1	SPAG9 MAPK8IP3	2.66e-05	5	31	2	PS51776
Domain	-	PKHD1 SHCBP1L	3.98e-05	6	31	2	2.160.20.10
Domain	Pectin_lyas_fold	PKHD1 SHCBP1L	3.98e-05	6	31	2	IPR012334
Domain	PbH1	PKHD1 SHCBP1L	3.98e-05	6	31	2	IPR006626
Domain	PbH1	PKHD1 SHCBP1L	3.98e-05	6	31	2	SM00710
Domain	Pectin_lyase_fold/virulence	PKHD1 SHCBP1L	7.42e-05	8	31	2	IPR011050
Domain	WD40_repeat_dom	SPAG9 WDR62 UBR4 MAPK8IP3	1.41e-03	297	31	4	IPR017986
Domain	-	SPAG9 WDR62 MAPK8IP3 SEMA4C	2.14e-03	333	31	4	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	SPAG9 WDR62 MAPK8IP3 SEMA4C	2.18e-03	335	31	4	IPR015943
Domain	CUB	CUZD1 CSMD1	2.99e-03	49	31	2	PF00431
Domain	CUB	CUZD1 CSMD1	3.11e-03	50	31	2	SM00042
Domain	-	CUZD1 CSMD1	3.36e-03	52	31	2	2.60.120.290
Domain	CUB	CUZD1 CSMD1	3.49e-03	53	31	2	PS01180
Domain	Quinoprotein_ADH-like_supfam	AASDH WDR62	3.49e-03	53	31	2	IPR011047
Domain	CUB_dom	CUZD1 CSMD1	4.02e-03	57	31	2	IPR000859
Pubmed	Structural characterization of the RH1-LZI tandem of JIP3/4 highlights RH1 domains as a cytoskeletal motor-binding motif.	SPAG9 MAPK8IP3	8.20e-07	2	32	2	31690808
Pubmed	Overlapping roles of JIP3 and JIP4 in promoting axonal transport of lysosomes in human iPSC-derived neurons.	SPAG9 MAPK8IP3	8.20e-07	2	32	2	33788575
Pubmed	JSAP1/JIP3 and JLP regulate kinesin-1-dependent axonal transport to prevent neuronal degeneration.	SPAG9 MAPK8IP3	2.46e-06	3	32	2	25571974
Pubmed	Bruton's tyrosine kinase regulates TLR9 but not TLR7 signaling in human plasmacytoid dendritic cells.	TLR7 BTK	2.46e-06	3	32	2	24375473
Pubmed	JSAP1 and JLP are required for ARF6 localization to the midbody in cytokinesis.	SPAG9 MAPK8IP3	2.46e-06	3	32	2	25130574
Pubmed	The scaffold protein JIP3 functions as a downstream effector of the small GTPase ARF6 to regulate neurite morphogenesis of cortical neurons.	SPAG9 MAPK8IP3	2.46e-06	3	32	2	20493856
Pubmed	Critical role of JSAP1 and JLP in axonal transport in the cerebellar Purkinje cells of mice.	SPAG9 MAPK8IP3	2.46e-06	3	32	2	26320416
Pubmed	Bruton's tyrosine kinase regulates TLR7/8-induced TNF transcription via nuclear factor-κB recruitment.	TLR7 BTK	4.92e-06	4	32	2	29567473
Pubmed	Kinesin-dependent axonal transport is mediated by the sunday driver (SYD) protein.	SPAG9 MAPK8IP3	4.92e-06	4	32	2	11106729
Pubmed	Autoreactive B cell responses to RNA-related antigens due to TLR7 gene duplication.	TLR7 BTK	8.19e-06	5	32	2	16709748
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	UTP20 SPAG9 IFRD1 ADGRL2 IQGAP2 UBR4 HELLS	1.06e-05	857	32	7	25609649
Pubmed	LRRK2 and the stress response: interaction with MKKs and JNK-interacting proteins.	SPAG9 MAPK8IP3	1.23e-05	6	32	2	20173330
Pubmed	Bruton's tyrosine kinase and protein kinase C µ are required for TLR7/9-induced IKKα and IRF-1 activation and interferon-β production in conventional dendritic cells.	TLR7 BTK	1.72e-05	7	32	2	25170774
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	UTP20 IFRD1 LBR ADGRL2 UBR4 SEMA4C HELLS	1.95e-05	942	32	7	31073040
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	SPAG9 LBR ADGRL2 IQGAP2 SEMA4C HELLS	6.73e-05	777	32	6	35844135
Pubmed	Morphogenesis of the telencephalic commissure requires scaffold protein JNK-interacting protein 3 (JIP3).	SPAG9 MAPK8IP3	1.54e-04	20	32	2	12897243
Pubmed	Nucleome Dynamics during Retinal Development.	LBR HELLS	1.87e-04	22	32	2	31493975
Pubmed	Role of the JIP4 scaffold protein in the regulation of mitogen-activated protein kinase signaling pathways.	SPAG9 MAPK8IP3	1.87e-04	22	32	2	15767678
Pubmed	Proteomic analysis of the epidermal growth factor receptor (EGFR) interactome and post-translational modifications associated with receptor endocytosis in response to EGF and stress.	OSBP NGLY1 UBR4 HELLS	2.14e-04	323	32	4	24797263
Pubmed	LZTR1 is a regulator of RAS ubiquitination and signaling.	TAOK3 BTK SEMA4C	2.18e-04	127	32	3	30442766
Pubmed	Genome-wide CRISPR screens using isogenic cells reveal vulnerabilities conferred by loss of tumor suppressors.	NGLY1 ACTR5 BTK MAPK8IP3	3.19e-04	359	32	4	35559673
Pubmed	A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.	PDCD2 SPAG9 IQGAP2	4.46e-04	162	32	3	14743216
Pubmed	The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin.	IFRD1 TFB2M IQGAP2 HELLS	4.80e-04	400	32	4	35013556
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	PKHD1 UTP20 APPBP2 SPAG9 UBR4	5.25e-04	736	32	5	29676528
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	UTP20 OSBP SPAG9 WDR62 MAPK8IP3	6.59e-04	774	32	5	15302935
Pubmed	FAM105A/OTULINL Is a Pseudodeubiquitinase of the OTU-Class that Localizes to the ER Membrane.	OSBP LBR ADGRL2 SEMA4C	8.64e-04	468	32	4	31056421
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	OSBP BTK	2.15e-02	206	20	2	682
Coexpression	GSE25146_UNSTIM_VS_HELIOBACTER_PYLORI_LPS_STIM_AGS_CELL_UP	UTP20 PTPN7 BTK WDR62 MAPK8IP3 HELLS	7.54e-08	180	32	6	M8127
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Granulocytic\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PTPN7 ADGRL2 IQGAP2 BTK	6.82e-06	172	32	4	3a37569a5902f3c65ff8d3912421309a8c82ee9b
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Granulocytic-Mast_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PTPN7 ADGRL2 IQGAP2 BTK	6.82e-06	172	32	4	cc9d9dae290f11f8c348c78228af4e49469dc93b
ToppCell	PND07-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-Treg-Treg_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PTPN7 LBR WDR62 HELLS	7.64e-06	177	32	4	f10f77130dbb2c0ad1b436ceb4fb1deac2b0267c
ToppCell	LPS_IL1RA_TNF-Hematopoietic_Myeloid-Dendritic_cells-pDC\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	PTPN7 TLR7 NGLY1 IQGAP2	1.16e-05	197	32	4	8fa38fb95e285f9cc756ec4f32009be4ede09d3c
ToppCell	Control_saline-Hematopoietic_Myeloid-Dendritic_cells-pDC\|Control_saline / Treatment groups by lineage, cell group, cell type	TLR7 NGLY1 IQGAP2 BTK	1.21e-05	199	32	4	34b95e27581bb127e0b921e9c068dc094cb86b37
Disease	squamous cell carcinoma, multiple keratinocyte carcinoma susceptibility measurement, basal cell carcinoma	PKHD1 CSMD1	7.23e-05	13	29	2	EFO_0000707, EFO_0004193, EFO_0007932
Disease	physical activity	PKHD1 ABCC9 CSMD1	8.85e-05	88	29	3	EFO_0003940
Disease	triacylglycerol 48:1 measurement	SPAG9 CSMD1	1.26e-04	17	29	2	EFO_0010404
Disease	triacylglycerol 50:2 measurement	SPAG9 CSMD1	4.26e-04	31	29	2	EFO_0010409
Disease	progression free survival, response to carboplatin, methylcobalamin deficiency type cblE, ovarian carcinoma	ADGRL2 IQGAP2	6.76e-04	39	29	2	EFO_0001075, EFO_0004920, GO_0097328, MONDO_0009354
Disease	systemic lupus erythematosus (implicated_via_orthology)	TLR7 LBR	8.21e-04	43	29	2	DOID:9074 (implicated_via_orthology)
Disease	cannabis dependence measurement	PKHD1 CSMD1	1.02e-03	48	29	2	EFO_0008457
Disease	health literacy measurement	UTP20 CSMD1	1.25e-03	53	29	2	EFO_0010104
Disease	serum selenium measurement	PKHD1 CSMD1	1.25e-03	53	29	2	EFO_0005266

Protein segments in the cluster

Peptide	Gene	Start	Entry
GYYKDSLHCEWIIEA	CSMD1	776	Q96PZ7
VYTIMYSCWHEKADE	BTK	626	Q06187
IDYKSYGTEKACWLH	ADGRL2	971	O95490
KLYAWEHIFCKSVEE	ABCC9	506	O60706
QHAYALDIYRKKCVW	AASDH	876	Q4L235
LFAKSHYDEAYKWCI	APPBP2	216	Q92624
HYDEAYKWCIEAMKE	APPBP2	221	Q92624
YIAEDYVEELHKWRC	ACTR5	251	Q9H9F9
KEKCVHYWPTEEETY	PTPN7	201	P35236
RDEYHCKKKYGVAWE	LBR	586	Q14739
VHDKVWCGYRNKIYV	SPAG9	1056	O60271
CYWKYLIVDEGHRIK	HELLS	346	Q9NRZ9
YDRVWCGYKNKVHVI	MAPK8IP3	1056	Q9UPT6
KDEVVDVTWRYSCKH	NGLY1	381	Q96IV0
TWQCELEVYKATYHF	KIAA1109	476	Q2LD37
KAYYCSKEHQTLDWR	PDCD2	151	Q16342
KELTHIYRGEYWECK	OSBP	781	P22059
HLYCIWCGTAYEDKE	GPATCH11	256	Q8N954
IKKWQCVYKQYDRDH	CAPNS2	151	Q96L46
ERMYIDCWVKKHTYD	IFRD1	361	O00458
DCWVKKHTYDTFKEV	IFRD1	366	O00458
ELAYCVWHIQVEKDY	CUZD1	176	Q86UP6
WKVYYEHLEKAATHA	UTP20	756	O75691
IAYEYLCHLEEAKRW	IQGAP2	36	Q13576
YNYVEDSCWTKHCKE	SHOC1	816	Q5VXU9
AEAVECWKKYYEIVM	SHCBP1L	331	Q9BZQ2
EYKGCYLKEHTAWLV	TAOK3	86	Q9H2K8
TIERSKDCAYKWLYD	TFB2M	376	Q9H5Q4
VKEDLYTCYEHVWTL	PKHD1	836	P08F94
KEYHEEAQKWDRYTD	SEMA4C	346	Q9C0C4
IDHEIVEKDAWKYYA	PLA2R1	361	Q13018
VEKDAWKYYATHCEP	PLA2R1	366	Q13018
GTICYDSTHYKETWK	AKR1A1	131	P14550
DVWYIYHFCKAKIKG	TLR7	866	Q9NYK1
CVYKDHSIYIWDVKD	WDR62	376	O43379
DYCLHVLKSLLEYWK	UBR4	3096	Q5T4S7