Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	SH3 domain binding	ZNF106 WIPF1 ARHGAP31 ADAM15	2.74e-04	143	44	4	GO:0017124
Domain	DUF4599	SPATA31D4 SPATA31D3	3.53e-04	12	44	2	PF15371
Domain	DUF4599	SPATA31D4 SPATA31D3	3.53e-04	12	44	2	IPR027970
Domain	PAS-assoc_C	PER3 KCNH2	1.45e-03	24	44	2	IPR000700
Domain	PAC	PER3 KCNH2	1.70e-03	26	44	2	SM00086
Domain	PAC	PER3 KCNH2	1.70e-03	26	44	2	PS50113
Domain	PAC	PER3 KCNH2	1.70e-03	26	44	2	IPR001610
Domain	PAS	PER3 KCNH2	2.57e-03	32	44	2	SM00091
Domain	PAS	PER3 KCNH2	2.90e-03	34	44	2	IPR000014
Domain	PAS	PER3 KCNH2	2.90e-03	34	44	2	PS50112
Pathway	WP_PHOTODYNAMIC_THERAPYINDUCED_AP1_SURVIVAL_SIGNALING	BCL3 BCL2L11 RB1	1.09e-04	51	26	3	M39438
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	SPATA31D4 WHRN SPATA31D3 LMTK3 IQCE PDE4DIP	6.35e-07	233	46	6	37704626
Pubmed	Suppression of tumorigenicity of rat liver tumor cells by human chromosome 13: evidence against the involvement of pRb and BRCA2.	BRCA2 RB1	1.71e-06	2	46	2	11788883
Pubmed	RB1 loss overrides PARP inhibitor sensitivity driven by RNASEH2B loss in prostate cancer.	BRCA2 RB1	5.13e-06	3	46	2	35179959
Pubmed	The NF-kappaB regulator Bcl-3 and the BH3-only proteins Bim and Puma control the death of activated T cells.	BCL3 BCL2L11	1.03e-05	4	46	2	16832056
Pubmed	A highly efficient ligand-regulated Cre recombinase mouse line shows that LoxP recombination is position dependent.	BRCA2 RB1	1.03e-05	4	46	2	11306549
Pubmed	Murine Oviductal High-Grade Serous Carcinomas Mirror the Genomic Alterations, Gene Expression Profiles, and Immune Microenvironment of Their Human Counterparts.	BRCA2 RB1	1.03e-05	4	46	2	31806642
Pubmed	Isolation of novel heart-specific genes using the BodyMap database.	KCNH2 PDE4DIP	1.71e-05	5	46	2	11374908
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	ZNF469 USF3 ATF5 LMTK3 ARHGAP31 IQCE	2.13e-05	430	46	6	35044719
Pubmed	Suppression of polyploidy by the BRCA2 protein.	BRCA2 RB1	2.56e-05	6	46	2	17686574
Pubmed	High-grade serous carcinomas arise in the mouse oviduct via defects linked to the human disease.	BRCA2 RB1	2.56e-05	6	46	2	28608929
Pubmed	Consortium analysis of 7 candidate SNPs for ovarian cancer.	BRCA2 RB1	3.58e-05	7	46	2	18431743
Pubmed	The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.	PRR12 GSE1 BRCA2 ZC3H3	4.96e-05	152	46	4	38360978
Pubmed	ACMG recommendations for reporting of incidental findings in clinical exome and genome sequencing.	BRCA2 RB1 KCNH2	6.03e-05	57	46	3	23788249
Pubmed	Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins.	RIPOR1 LMTK3 MBD6	8.13e-05	63	46	3	11572484
Pubmed	Identification and comparative analysis of hepatitis C virus-host cell protein interactions.	GORASP2 ADAR	9.34e-05	11	46	2	24136289
Pubmed	Genetically engineered mouse models of brain cancer and the promise of preclinical testing.	BRCA2 RB1	1.12e-04	12	46	2	19076778
Pubmed	Mouse models in tumor suppression.	BRCA2 RB1	1.12e-04	12	46	2	9917000
Pubmed	Trp53 and Rb1 regulate autophagy and ligand-dependent Hedgehog signaling.	NKX6-1 RB1	1.32e-04	13	46	2	32568216
Pubmed	Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.	USF3 WWC3 ADAR ADAM15	1.46e-04	201	46	4	23535732
Pubmed	Evaluating Effects of Hypomorphic Thoc1 Alleles on Embryonic Development in Rb1 Null Mice.	BCL2L11 RB1	1.54e-04	14	46	2	27001308
Pubmed	Retinoblastoma tumor suppressor protein in pancreatic progenitors controls α- and β-cell fate.	NKX6-1 RB1	2.03e-04	16	46	2	23946427
Pubmed	Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	PRR12 WWC3 ARHGAP31	3.49e-04	103	46	3	10574462
Pubmed	Use of expression data and the CGEMS genome-wide breast cancer association study to identify genes that may modify risk in BRCA1/2 mutation carriers.	HNRNPDL BRCA2	3.89e-04	22	46	2	18095154
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PRR12 RIPOR1 LRFN1 MBD6 BCL2L11 KCNH2 IQCE	5.81e-04	1105	46	7	35748872
Pubmed	A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers.	ZNF106 BRCA2 RB1	6.15e-04	125	46	3	21654808
Pubmed	Rewiring of RSK-PDZ Interactome by Linear Motif Phosphorylation.	WHRN GORASP2	9.35e-04	34	46	2	30726710
Pubmed	A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.	GORASP2 DRAP1 MBD6 PCBP4 PDE4DIP	1.22e-03	608	46	5	16713569
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	NUDT19 MAMSTR PRR12 LRFN1 ATF5 BCL3 LMTK3 GGN	2.19e-05	1192	46	8	chr19q13
Cytoband	9q21.32	SPATA31D4 SPATA31D3	1.66e-04	19	46	2	9q21.32
Cytoband	19q13.33	MAMSTR PRR12 LMTK3	1.69e-04	106	46	3	19q13.33
Cytoband	2q31.1	GORASP2 WIPF1	3.25e-03	84	46	2	2q31.1
Coexpression	TABULA_MURIS_SENIS_PANCREAS_PANCREATIC_BETA_CELL_AGEING	ATF5 NKX6-1 MBD6 ZC3H3 KCNH2	2.77e-05	212	44	5	MM3816
Coexpression	ZHU_CMV_ALL_UP	GORASP2 ATF5 BRCA2 RB1	3.14e-05	107	44	4	M19630
Drug	17-AAG; Down 200; 1uM; MCF7; HT_HG-U133A	RIPOR1 BCL3 KCNH2 ADAM15 IQCE	3.58e-05	190	45	5	5223_DN
Drug	LY 294002; Down 200; 10uM; MCF7; HT_HG-U133A	HNRNPDL RIPOR1 BCL3 PER3 KCNH2	3.95e-05	194	45	5	5599_DN
Drug	radicicol, diheterospora chlamydosporia; Down 200; 0.1uM; MCF7; HT_HG-U133A	RIPOR1 BCL2L11 ZC3H3 CAPN15 PDE4DIP	3.95e-05	194	45	5	5216_DN
Drug	Talampicillin hydrochloride [39878-70-1]; Up 200; 7.8uM; PC3; HT_HG-U133A	C7 BCL3 WIPF1 BCL2L11 BRCA2	4.05e-05	195	45	5	7254_UP
Drug	Hemicholinium bromide [312-45-8]; Down 200; 7uM; PC3; HT_HG-U133A	WHRN RIPOR1 WIPF1 BCL2L11 CAPN15	4.05e-05	195	45	5	6739_DN
Drug	Luteolin [491-70-3]; Down 200; 14uM; MCF7; HT_HG-U133A	HNRNPDL RIPOR1 WWC3 IQCE PDE4DIP	4.05e-05	195	45	5	5004_DN
Drug	rapamycin; Down 200; 0.1uM; MCF7; HT_HG-U133A_EA	ATF5 BRCA2 PCBP4 ADAM15 PDE4DIP	4.15e-05	196	45	5	921_DN
Drug	PHA-00846566E [724718-26-7]; Down 200; 10uM; PC3; HT_HG-U133A	WHRN PER3 BCL2L11 CAPN15 PDE4DIP	4.57e-05	200	45	5	7046_DN
Drug	Iohexol [66108-95-0]; Up 200; 4.8uM; MCF7; HT_HG-U133A	WHRN RIPOR1 ATF5 PER3 CAPN15	4.57e-05	200	45	5	3322_UP
Disease	Neoplasm of the genitourinary tract	BRCA2 RB1	5.10e-04	24	41	2	cv:C0042065
Disease	Neoplasm of uncertain or unknown behavior of breast	BRCA2 RB1	1.49e-03	41	41	2	C0496956
Disease	Breast adenocarcinoma	BRCA2 RB1	1.49e-03	41	41	2	C0858252
Disease	keratoconus	ZNF106 ZNF469	3.82e-03	66	41	2	MONDO_0015486

Protein segments in the cluster

Peptide	Gene	Start	Entry
ASALSFPAPPSRPLP	ADAM15	761	Q13444
LRSPFYPIPTPGSLP	GSE1	276	Q14687
PPASPGPFATRSPLF	BCL2L11	66	O43521
PPAPSLPLSLPSFDL	ATF5	136	Q9Y2D1
SPPTPFLPFASTLPL	DRAP1	171	Q14919
PRSPYKFPSSPLRIP	RB1	786	P06400
ASSPPFLAALPDPSP	IQCE	646	Q6IPM2
PPPLFPSAPATLASR	HNRNPDL	11	O14979
PPRVPPFSPFSSTLQ	CAPN15	226	O75808
SSAPADLPAPFSPPL	PCBP4	321	P57723
LPPPSAPPSNLLASF	MBD6	611	Q96DN6
APLPLPSEFLPSFPL	GORASP2	356	Q9H8Y8
LGPAPFSRTAFPSLP	NUDT19	91	A8MXV4
FSSALLSPPPAALPF	LRFN1	6	Q9P244
FLPFGIPLPFRSPSP	HPS5	521	Q9UPZ3
SPLRLVPFSSPRPPG	KCNH2	951	Q12809
SPLFPAPRPFPAQSS	LMTK3	586	Q96Q04
FLPDPPVCPLLSPSF	PER3	851	P56645
SPPLPSPTYRPLLGF	PCED1B	291	Q96HM7
PPVPLPFFLSLALPS	KRTAP4-16	171	G5E9R7
PFFLSLALPSPPRPS	KRTAP4-16	176	G5E9R7
IFPFSPRSPFQPLIP	PCOTH	36	Q58A44
PAPALLAPPTFIFPA	GGN	406	Q86UU5
TPSLPPSLPGLRPRF	ADAR	61	P55265
PDPRPFPLPLSSLFS	BRCA2	2796	P51587
PEPTVFAFSPLRTPP	FUT10	421	Q6P4F1
FPLSLVPTEFCPSPP	C7	561	P10643
PLAPALPSGTAPFLF	MAMSTR	46	Q6ZN01
FFLPSPSPPAFLPFA	BCL3	421	P20749
LLAGLPRFSSLSPPP	NKX6-1	156	P78426
ADLFSPSPLRDPLPP	SPATA31D4	206	Q6ZUB0
CFIPPRPPIFNPFLT	PRR32	246	B1ATL7
LSSFKPLPRPPPLAQ	WHRN	576	Q9P202
PFPVPSSLSLQDPPF	PRR12	161	Q9ULL5
FSVLPLFLPPKPSTP	ADGRD2	941	Q7Z7M1
ADLFSPSPLRDPLPP	SPATA31D3	206	P0C874
APGLPFPLLEPFTTP	ZNF414	231	Q96IQ9
FPLLEPFTTPAPAPT	ZNF414	236	Q96IQ9
TPASPLSAPPFPLSL	ZC3H3	546	Q8IXZ2
FSNRPPLPPTPSRAL	WIPF1	246	O43516
LSPPRPVGFAQPSFP	USF3	2156	Q68DE3
PGRPQSLILFSPPFP	ARHGAP31	1341	Q2M1Z3
FLPSLAATPFPLPAS	ZNF469	816	Q96JG9
LSFRSFPVFSPPGPP	RIPOR1	36	Q6ZS17
LPTPFFPLFLEPPSS	ZNF106	1151	Q9H2Y7
LSPPSSPLDTPFLPA	WWC3	461	Q9ULE0
CLFPVPFPLTPSLRP	UNC79	71	Q9P2D8
LPQAPLPSAPSSFLP	PDE4DIP	1706	Q5VU43