Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	epoxide hydrolase activity	AKR7L AKR7A3 ALOX12	1.95e-05	11	100	3	GO:0004301
GeneOntologyMolecularFunction	glucan 1,4-alpha-glucosidase activity	MGAM MGAM2	2.48e-05	2	100	2	GO:0004339
GeneOntologyMolecularFunction	palmitoyl-CoA 9-desaturase activity	SCD5 SCD	2.48e-05	2	100	2	GO:0032896
GeneOntologyMolecularFunction	hydrolase activity, acting on ether bonds	AKR7L AKR7A3 ALOX12	3.36e-05	13	100	3	GO:0016801
GeneOntologyMolecularFunction	ether hydrolase activity	AKR7L AKR7A3 ALOX12	3.36e-05	13	100	3	GO:0016803
GeneOntologyMolecularFunction	phenanthrene-9,10-epoxide hydrolase activity	AKR7L AKR7A3	7.42e-05	3	100	2	GO:0019119
GeneOntologyMolecularFunction	phenanthrene-epoxide hydrolase activity	AKR7L AKR7A3	7.42e-05	3	100	2	GO:0019118
GeneOntologyMolecularFunction	threonine-tRNA ligase activity	TARS3 TARS1	7.42e-05	3	100	2	GO:0004829
GeneOntologyMolecularFunction	stearoyl-CoA 9-desaturase activity	SCD5 SCD	1.48e-04	4	100	2	GO:0004768
GeneOntologyMolecularFunction	acyl-CoA desaturase activity	SCD5 SCD	2.46e-04	5	100	2	GO:0016215
GeneOntologyMolecularFunction	alpha-1,4-glucosidase activity	MGAM MGAM2	2.46e-04	5	100	2	GO:0004558
GeneOntologyMolecularFunction	transition metal ion binding	TRIM72 SEMG2 FNTA CYP11B1 CA13 TRIM65 SCD5 MOXD1 USP51 SUOX LNPEP SCD KDM1B AGBL1 ALOX12 TARS1	2.67e-04	1189	100	16	GO:0046914
GeneOntologyMolecularFunction	alpha-glucosidase activity	MGAM MGAM2	5.13e-04	7	100	2	GO:0090599
GeneOntologyMolecularFunction	glucuronosyltransferase activity	UGT2A2 UGT2A3 UGT2A1	7.10e-04	35	100	3	GO:0015020
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	SCD5 SCD	1.87e-03	13	100	2	GO:0016717
GeneOntologyBiologicalProcess	monounsaturated fatty acid biosynthetic process	SCD5 SCD	2.33e-05	2	100	2	GO:1903966
GeneOntologyBiologicalProcess	threonyl-tRNA aminoacylation	TARS3 TARS1	6.96e-05	3	100	2	GO:0006435
GeneOntologyBiologicalProcess	tarsal gland development	SCD5 SCD	6.96e-05	3	100	2	GO:1903699
GeneOntologyBiologicalProcess	monounsaturated fatty acid metabolic process	SCD5 SCD	6.96e-05	3	100	2	GO:1903964
MousePheno	progressive hair loss	SCD5 GK5 SCD	1.42e-05	9	79	3	MP:0009004
MousePheno	abnormal sebaceous lipid secretion	SCD5 GK5 SCD	2.77e-05	11	79	3	MP:0002992
MousePheno	small perianal sebaceous gland	SCD5 SCD	9.43e-05	3	79	2	MP:0013382
MousePheno	abnormal perianal sebaceous gland morphology	SCD5 SCD	9.43e-05	3	79	2	MP:0013381
MousePheno	abnormal sebaceous gland physiology	SCD5 GK5 SCD	1.85e-04	20	79	3	MP:0002991
MousePheno	abnormal holocrine gland physiology	SCD5 GK5 SCD	1.85e-04	20	79	3	MP:0013556
MousePheno	sebaceous gland atrophy	SCD5 SCD	1.88e-04	4	79	2	MP:0000649
Domain	FATTY_ACID_DESATUR_1	SCD5 SCD	2.73e-05	2	98	2	PS00476
Domain	FADS-1_CS	SCD5 SCD	2.73e-05	2	98	2	IPR001522
Domain	Acyl-CoA_DS	SCD5 SCD	2.73e-05	2	98	2	IPR015876
Domain	ThrRS_core	TARS3 TARS1	8.15e-05	3	98	2	IPR033728
Domain	Thr-tRNA-ligase_IIa	TARS3 TARS1	8.15e-05	3	98	2	IPR002320
Domain	Apc4_WD40_dom	NWD1 EML5 WDHD1	1.50e-04	20	98	3	IPR024977
Domain	ANAPC4_WD40	NWD1 EML5 WDHD1	1.50e-04	20	98	3	PF12894
Domain	NtCtMGAM_N	MGAM MGAM2	1.62e-04	4	98	2	PF16863
Domain	Gal_mutarotase_N	MGAM MGAM2	1.62e-04	4	98	2	IPR031727
Domain	TGS	TARS3 TARS1	4.03e-04	6	98	2	IPR004095
Domain	TGS	TARS3 TARS1	4.03e-04	6	98	2	PF02824
Domain	Glyco_hydro_31_AS	MGAM MGAM2	4.03e-04	6	98	2	IPR030458
Domain	Butyrophylin	TRIM72 FSD2 TRIM65 BTNL3	5.01e-04	70	98	4	IPR003879
Domain	Glyco_hydro_31	MGAM MGAM2	5.63e-04	7	98	2	IPR000322
Domain	TGS-like	TARS3 TARS1	5.63e-04	7	98	2	IPR012676
Domain	tRNA_SAD	TARS3 TARS1	5.63e-04	7	98	2	SM00863
Domain	tRNA_SAD	TARS3 TARS1	5.63e-04	7	98	2	IPR012947
Domain	Glyco_hydro_31	MGAM MGAM2	5.63e-04	7	98	2	PF01055
Domain	GLYCOSYL_HYDROL_F31_1	MGAM MGAM2	5.63e-04	7	98	2	PS00129
Domain	tRNA_SAD	TARS3 TARS1	5.63e-04	7	98	2	PF07973
Domain	FA_desaturase_dom	SCD5 SCD	7.48e-04	8	98	2	IPR005804
Domain	Thr/Ala-tRNA-synth_IIc_edit	TARS3 TARS1	7.48e-04	8	98	2	IPR018163
Domain	FA_desaturase	SCD5 SCD	7.48e-04	8	98	2	PF00487
Domain	Trefoil	MGAM MGAM2	7.48e-04	8	98	2	PF00088
Domain	Ptc/Disp	PTCHD4 DISP1	9.58e-04	9	98	2	IPR003392
Domain	Patched	PTCHD4 DISP1	9.58e-04	9	98	2	PF02460
Domain	P_TREFOIL_2	MGAM MGAM2	9.58e-04	9	98	2	PS51448
Domain	HGTP_anticodon	TARS3 TARS1	9.58e-04	9	98	2	PF03129
Domain	PD	MGAM MGAM2	9.58e-04	9	98	2	SM00018
Domain	ConA-like_dom	TRIM72 CLSTN3 FSD2 TRIM65 COL24A1 BTNL3	1.04e-03	219	98	6	IPR013320
Domain	SPRY	TRIM72 FSD2 TRIM65 BTNL3	1.14e-03	87	98	4	SM00449
Domain	-	MGAM MGAM2	1.45e-03	11	98	2	4.10.110.10
Domain	aa-tRNA-synt_IIb	TARS3 TARS1	1.45e-03	11	98	2	IPR002314
Domain	tRNA-synt_2b	TARS3 TARS1	1.45e-03	11	98	2	PF00587
Domain	-	TARS3 TARS1	1.45e-03	11	98	2	3.40.50.800
Domain	SPRY	TRIM72 FSD2 TRIM65 BTNL3	1.51e-03	94	98	4	PF00622
Domain	SPRY_dom	TRIM72 FSD2 TRIM65 BTNL3	1.51e-03	94	98	4	IPR003877
Domain	B30.2/SPRY	TRIM72 FSD2 TRIM65 BTNL3	1.57e-03	95	98	4	IPR001870
Domain	B302_SPRY	TRIM72 FSD2 TRIM65 BTNL3	1.57e-03	95	98	4	PS50188
Domain	P_trefoil_dom	MGAM MGAM2	1.74e-03	12	98	2	IPR000519
Domain	PH_dom-like	RASA3 TNS2 ELMO1 PRKD3 PLCD3 SPTBN5 PREX1 NSMAF	1.80e-03	426	98	8	IPR011993
Domain	SSD	PTCHD4 DISP1	2.05e-03	13	98	2	IPR000731
Domain	SSD	PTCHD4 DISP1	2.05e-03	13	98	2	PS50156
Domain	Beta-grasp_dom	TARS3 TARS1	2.38e-03	14	98	2	IPR012675
Domain	-	TARS3 TARS1	2.38e-03	14	98	2	3.10.20.30
Domain	Anticodon-bd	TARS3 TARS1	2.38e-03	14	98	2	IPR004154
Domain	PH	RASA3 ELMO1 PRKD3 PLCD3 SPTBN5 PREX1	3.46e-03	278	98	6	SM00233
Domain	PH_DOMAIN	RASA3 ELMO1 PRKD3 PLCD3 SPTBN5 PREX1	3.52e-03	279	98	6	PS50003
Domain	Gal_mutarotase_SF_dom	MGAM MGAM2	3.52e-03	17	98	2	IPR011013
Domain	NADP_OxRdtase_dom	AKR7L AKR7A3	3.52e-03	17	98	2	IPR023210
Domain	Aldo_ket_red	AKR7L AKR7A3	3.52e-03	17	98	2	PF00248
Domain	Aldo/ket_red/Kv-b	AKR7L AKR7A3	3.52e-03	17	98	2	IPR001395
Domain	PH_domain	RASA3 ELMO1 PRKD3 PLCD3 SPTBN5 PREX1	3.58e-03	280	98	6	IPR001849
Domain	aa-tRNA-synth_II	TARS3 TARS1	3.95e-03	18	98	2	IPR006195
Domain	AA_TRNA_LIGASE_II	TARS3 TARS1	3.95e-03	18	98	2	PS50862
Domain	-	RASA3 TNS2 ELMO1 PRKD3 PLCD3 SPTBN5 PREX1	4.52e-03	391	98	7	2.30.29.30
Domain	UDPGT	UGT2A3 UGT2A1	5.36e-03	21	98	2	PF00201
Domain	UDPGT	UGT2A3 UGT2A1	5.36e-03	21	98	2	PS00375
Domain	UDP_glucos_trans	UGT2A3 UGT2A1	5.36e-03	21	98	2	IPR002213
Pathway	KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS	ACOT4 SCD5 SCD	1.99e-04	22	74	3	M11673
Pathway	REACTOME_GLUCURONIDATION	UGT2A2 UGT2A3 UGT2A1	2.60e-04	24	74	3	MM14599
Pathway	REACTOME_GLUCURONIDATION	UGT2A2 UGT2A3 UGT2A1	2.94e-04	25	74	3	M17787
Pathway	WP_GLUCURONIDATION	UGT2A2 UGT2A3 UGT2A1	2.94e-04	25	74	3	MM15820
Pathway	WP_GLUCURONIDATION	UGT2A2 UGT2A3 UGT2A1	3.31e-04	26	74	3	M39404
Pathway	WP_AFLATOXIN_B1_METABOLISM	AKR7L AKR7A3	4.02e-04	6	74	2	MM15846
Pubmed	Human UDP-glucuronosyltransferase UGT2A2: cDNA construction, expression, and functional characterization in comparison with UGT2A1 and UGT2A3.	UGT2A2 UGT2A3 UGT2A1	2.45e-08	3	102	3	19858781
Pubmed	Analysis of mouse embryonic patterning and morphogenesis by forward genetics.	DYNC2H1 IFT172 HECTD1 DISP1	2.67e-06	33	102	4	15755804
Pubmed	The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells.	RASA3 TBX21 TNS2 FANCA PRKD3 PRRT1 PREX1	5.02e-06	227	102	7	26410627
Pubmed	Mouse models of psoriasis.	SCD5 ITGAE SCD	6.86e-06	13	102	3	17429444
Pubmed	Obesity resistance of the stearoyl-CoA desaturase-deficient (scd1-/-) mouse results from disruption of the epidermal lipid barrier and adaptive thermoregulation.	SCD5 SCD	8.52e-06	2	102	2	17391062
Pubmed	Increased hydrophilic plasma bile acids are correlated with protection from adiposity in skin-specific stearoyl-CoA desaturase-1 deficient mice.	SCD5 SCD	8.52e-06	2	102	2	29965978
Pubmed	Effects of CRISPR/Cas9-mediated stearoyl-Coenzyme A desaturase 1 knockout on mouse embryo development and lipid synthesis.	SCD5 SCD	8.52e-06	2	102	2	36124130
Pubmed	[Role of stearoyl-CoA desaturase in regulation of energy metabolism].	SCD5 SCD	8.52e-06	2	102	2	18788462
Pubmed	beta-Adrenergic control of stearoyl-CoA desaturase 1 repression in relation to sympathoadrenal regulation of thermogenesis.	SCD5 SCD	8.52e-06	2	102	2	16801925
Pubmed	Scd1 is expressed in sebaceous glands and is disrupted in the asebia mouse.	SCD5 SCD	8.52e-06	2	102	2	10545940
Pubmed	Metabolic changes in skin caused by Scd1 deficiency: a focus on retinol metabolism.	SCD5 SCD	8.52e-06	2	102	2	21573029
Pubmed	Characterization of human SCD2, an oligomeric desaturase with improved stability and enzyme activity by cross-linking in intact cells.	SCD5 SCD	8.52e-06	2	102	2	15610069
Pubmed	Characterization of HSCD5, a novel human stearoyl-CoA desaturase unique to primates.	SCD5 SCD	8.52e-06	2	102	2	15907797
Pubmed	Nuclear factor 1 is essential for the expression of stearoyl-CoA desaturase 1 gene during preadipocyte differentiation.	SCD5 SCD	8.52e-06	2	102	2	9689914
Pubmed	Loss of threonyl-tRNA synthetase-like protein Tarsl2 has little impact on protein synthesis but affects mouse development.	TARS3 TARS1	8.52e-06	2	102	2	37059185
Pubmed	Dietary fat is a lipid source in 2,3,7,8-tetrachlorodibenzo-ρ-dioxin (TCDD)-elicited hepatic steatosis in C57BL/6 mice.	SCD5 SCD	8.52e-06	2	102	2	22539624
Pubmed	Loss of Stearoyl-CoA desaturase-1 attenuates adipocyte inflammation: effects of adipocyte-derived oleate.	SCD5 SCD	8.52e-06	2	102	2	19910642
Pubmed	The expression of the gene asebia in the laboratory mouse. I. Epidermis and dermis.	SCD5 SCD	8.52e-06	2	102	2	631559
Pubmed	SCD1 is nutritionally and spatially regulated in the intestine and influences systemic postprandial lipid homeostasis and gut-liver crosstalk.	SCD5 SCD	8.52e-06	2	102	2	35718096
Pubmed	Skin lipids of a normal and mutant (asebic) mouse strain.	SCD5 SCD	8.52e-06	2	102	2	5924301
Pubmed	SCD1 promotes lipid mobilization in subcutaneous white adipose tissue.	SCD5 SCD	8.52e-06	2	102	2	32978274
Pubmed	Stearoyl-CoA desaturase 1 deficiency elevates insulin-signaling components and down-regulates protein-tyrosine phosphatase 1B in muscle.	SCD5 SCD	8.52e-06	2	102	2	12960377
Pubmed	Mice fed a lipogenic methionine-choline-deficient diet develop hypermetabolism coincident with hepatic suppression of SCD-1.	SCD5 SCD	8.52e-06	2	102	2	16829692
Pubmed	Dietary cholesterol opposes PUFA-mediated repression of the stearoyl-CoA desaturase-1 gene by SREBP-1 independent mechanism.	SCD5 SCD	8.52e-06	2	102	2	12364560
Pubmed	A threonyl-tRNA synthetase-like protein has tRNA aminoacylation and editing activities.	TARS3 TARS1	8.52e-06	2	102	2	29579307
Pubmed	Stearoyl-CoA desaturase-1 mediates the pro-lipogenic effects of dietary saturated fat.	SCD5 SCD	8.52e-06	2	102	2	17127673
Pubmed	A lipogenic diet in mice with a disruption of the stearoyl-CoA desaturase 1 gene reveals a stringent requirement of endogenous monounsaturated fatty acids for triglyceride synthesis.	SCD5 SCD	8.52e-06	2	102	2	11441127
Pubmed	Loss of stearoyl-CoA desaturase activity leads to free cholesterol synthesis through increased Xbp-1 splicing.	SCD5 SCD	8.52e-06	2	102	2	20923962
Pubmed	SCD1 inhibition during 3T3-L1 adipocyte differentiation remodels triacylglycerol, diacylglycerol and phospholipid fatty acid composition.	SCD5 SCD	8.52e-06	2	102	2	25959085
Pubmed	Metabolic rerouting via SCD1 induction impacts X-linked adrenoleukodystrophy.	SCD5 SCD	8.52e-06	2	102	2	33690217
Pubmed	Human stearoyl-CoA desaturase 1 (SCD-1) gene expression is negatively regulated by thyroid hormone without direct binding of thyroid hormone receptor to the gene promoter.	SCD5 SCD	8.52e-06	2	102	2	23221600
Pubmed	Lung fibroblasts promote metastatic colonization through upregulation of stearoyl-CoA desaturase 1 in tumor cells.	SCD5 SCD	8.52e-06	2	102	2	29326439
Pubmed	Regulation of stearoyl-CoA desaturase by polyunsaturated fatty acids and cholesterol.	SCD5 SCD	8.52e-06	2	102	2	10484602
Pubmed	Scd1 plays a tumor-suppressive role in survival of leukemia stem cells and the development of chronic myeloid leukemia.	SCD5 SCD	8.52e-06	2	102	2	22431519
Pubmed	Relationship between stearoyl-CoA desaturase activity and plasma triglycerides in human and mouse hypertriglyceridemia.	SCD5 SCD	8.52e-06	2	102	2	12401889
Pubmed	Scd3--a novel gene of the stearoyl-CoA desaturase family with restricted expression in skin.	SCD5 SCD	8.52e-06	2	102	2	11161812
Pubmed	Peroxisome proliferators induce mouse liver stearoyl-CoA desaturase 1 gene expression.	SCD5 SCD	8.52e-06	2	102	2	8790349
Pubmed	Early-life exposure to bisphenol A induces dysregulation of lipid homeostasis by the upregulation of SCD1 in male mice.	SCD5 SCD	8.52e-06	2	102	2	35341816
Pubmed	Lack of stearoyl-CoA desaturase-1 function induces a palmitoyl-CoA Delta6 desaturase and represses the stearoyl-CoA desaturase-3 gene in the preputial glands of the mouse.	SCD5 SCD	8.52e-06	2	102	2	12454277
Pubmed	Stearoyl-CoA desaturase 1 activity is required for autophagosome formation.	SCD5 SCD	8.52e-06	2	102	2	25023287
Pubmed	Combined deletion of SCD1 from adipose tissue and liver does not protect mice from obesity.	SCD5 SCD	8.52e-06	2	102	2	22669918
Pubmed	Stearoyl-CoA desaturase 1 deficiency increases insulin signaling and glycogen accumulation in brown adipose tissue.	SCD5 SCD	8.52e-06	2	102	2	15494611
Pubmed	Elevated stearoyl-CoA desaturase in brains of patients with Alzheimer's disease.	SCD5 SCD	8.52e-06	2	102	2	22046234
Pubmed	Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity.	SCD5 SCD	8.52e-06	2	102	2	12177411
Pubmed	Dyslipidemia and atherosclerosis induced by chronic intermittent hypoxia are attenuated by deficiency of stearoyl coenzyme A desaturase.	SCD5 SCD	8.52e-06	2	102	2	18832746
Pubmed	Stearoyl-CoA desaturase 1 deficiency protects mice from immune-mediated liver injury.	SCD5 SCD	8.52e-06	2	102	2	19002112
Pubmed	Aberrant lipid metabolism in anaplastic thyroid carcinoma reveals stearoyl CoA desaturase 1 as a novel therapeutic target.	SCD5 SCD	8.52e-06	2	102	2	25675381
Pubmed	Targeted disruption of stearoyl-CoA desaturase1 gene in mice causes atrophy of sebaceous and meibomian glands and depletion of wax esters in the eyelid.	SCD5 SCD	8.52e-06	2	102	2	11533264
Pubmed	Glycerol regulates stratum corneum hydration in sebaceous gland deficient (asebia) mice.	SCD5 SCD	8.52e-06	2	102	2	12713573
Pubmed	Hepatic stearoyl-CoA desaturase-1 deficiency protects mice from carbohydrate-induced adiposity and hepatic steatosis.	SCD5 SCD	8.52e-06	2	102	2	18054317
Pubmed	Membrane topology of mouse stearoyl-CoA desaturase 1.	SCD5 SCD	8.52e-06	2	102	2	16275639
Pubmed	Stearoyl-CoA desaturase 1 (Scd1) gene overexpression is associated with genetic predisposition to hepatocarcinogenesis in mice and rats.	SCD5 SCD	8.52e-06	2	102	2	12419843
Pubmed	Lack of stearoyl-CoA desaturase 1 upregulates basal thermogenesis but causes hypothermia in a cold environment.	SCD5 SCD	8.52e-06	2	102	2	15210843
Pubmed	Liver gene expression analysis reveals endoplasmic reticulum stress and metabolic dysfunction in SCD1-deficient mice fed a very low-fat diet.	SCD5 SCD	8.52e-06	2	102	2	18381840
Pubmed	Identification of a novel SCD gene and expression of the SCD gene family in mouse skin.	SCD5 SCD	8.52e-06	2	102	2	10674390
Pubmed	Stearoly-CoA desaturase 1 differentiates early and advanced dengue virus infections and determines virus particle infectivity.	SCD5 SCD	8.52e-06	2	102	2	30118512
Pubmed	Asebia-2J (Scd1(ab2J)): a new allele and a model for scarring alopecia.	SCD5 SCD	8.52e-06	2	102	2	10854228
Pubmed	Diet-induced changes in stearoyl-CoA desaturase 1 expression in obesity-prone and -resistant mice.	SCD5 SCD	8.52e-06	2	102	2	15340109
Pubmed	Loss of stearoyl-CoA desaturase 1 inhibits fatty acid oxidation and increases glucose utilization in the heart.	SCD5 SCD	8.52e-06	2	102	2	18042664
Pubmed	Alpha-linolenic acid increases cholesterol efflux in macrophage-derived foam cells by decreasing stearoyl CoA desaturase 1 expression: evidence for a farnesoid-X-receptor mechanism of action.	SCD5 SCD	8.52e-06	2	102	2	21658928
Pubmed	Stearoyl CoA desaturase 1 is elevated in obesity but protects against fatty acid-induced skeletal muscle insulin resistance in vitro.	SCD5 SCD	8.52e-06	2	102	2	17033839
Pubmed	Clofibrate treatment increases stearoyl-CoA desaturase mRNA level and enzyme activity in mouse liver.	SCD5 SCD	8.52e-06	2	102	2	8541340
Pubmed	Polyunsaturated fatty acids do not activate AMP-activated protein kinase in mouse tissues.	SCD5 SCD	8.52e-06	2	102	2	15916750
Pubmed	Overexpression of stearoyl-coenzyme A desaturase 1 in macrophages promotes reverse cholesterol transport.	SCD5 SCD	8.52e-06	2	102	2	23747827
Pubmed	Interplay between Thyroid Hormones and Stearoyl-CoA Desaturase 1 in the Regulation of Lipid Metabolism in the Heart.	SCD5 SCD	8.52e-06	2	102	2	33374300
Pubmed	Reduced SCD1 activity alters markers of fatty acid reesterification, glyceroneogenesis, and lipolysis in murine white adipose tissue and 3T3-L1 adipocytes.	SCD5 SCD	8.52e-06	2	102	2	28659287
Pubmed	Polyunsaturated fatty acids inhibit hepatic stearoyl-CoA desaturase-1 gene in diabetic mice.	SCD5 SCD	8.52e-06	2	102	2	8729090
Pubmed	Stearoyl-CoA desaturase regulates inflammatory gene expression by changing DNA methylation level in 3T3 adipocytes.	SCD5 SCD	8.52e-06	2	102	2	25130896
Pubmed	Discovery of potent and liver-selective stearoyl-CoA desaturase (SCD) inhibitors in an acyclic linker series.	SCD5 SCD	8.52e-06	2	102	2	22101133
Pubmed	Compartmentalization of stearoyl-coenzyme A desaturase 1 activity in HepG2 cells.	SCD5 SCD	8.52e-06	2	102	2	18599738
Pubmed	Structure and Mechanism of a Unique Diiron Center in Mammalian Stearoyl-CoA Desaturase.	SCD5 SCD	8.52e-06	2	102	2	32470559
Pubmed	Role of stearoyl-CoA desaturase-1 in skeletal muscle function and metabolism.	SCD5 SCD	8.52e-06	2	102	2	23941875
Pubmed	Stearoyl CoA Desaturase Is Essential for Regulation of Endoplasmic Reticulum Homeostasis and Tumor Growth in Glioblastoma Cancer Stem Cells.	SCD5 SCD	8.52e-06	2	102	2	30930246
Pubmed	Dietary regulation of stearoyl-CoA desaturase 1 gene expression in mouse liver.	SCD5 SCD	8.52e-06	2	102	2	1350282
Pubmed	Stearoyl-CoA Desaturase Promotes Liver Fibrosis and Tumor Development in Mice via a Wnt Positive-Signaling Loop by Stabilization of Low-Density Lipoprotein-Receptor-Related Proteins 5 and 6.	SCD5 SCD	8.52e-06	2	102	2	28143772
Pubmed	cDNA nucleotide sequence coding for stearoyl-CoA desaturase and its expression in the zebrafish (Danio rerio) embryo.	SCD5 SCD	8.52e-06	2	102	2	14579408
Pubmed	The biosynthesis of hepatic cholesterol esters and triglycerides is impaired in mice with a disruption of the gene for stearoyl-CoA desaturase 1.	SCD5 SCD	8.52e-06	2	102	2	10899171
Pubmed	Susceptibility of podocytes to palmitic acid is regulated by stearoyl-CoA desaturases 1 and 2.	SCD5 SCD	8.52e-06	2	102	2	23867797
Pubmed	Metabolomics reveals that hepatic stearoyl-CoA desaturase 1 downregulation exacerbates inflammation and acute colitis.	SCD5 SCD	8.52e-06	2	102	2	18249173
Pubmed	Differential expression of hepatic stearoyl-CoA desaturase gene 1 in male and female mice.	SCD5 SCD	8.52e-06	2	102	2	8954132
Pubmed	Overexpression of stearoyl-CoA desaturase 1 in bone-marrow mesenchymal stem cells increases osteogenesis.	SCD5 SCD	8.52e-06	2	102	2	24088802
Pubmed	Hepatic oleate regulates adipose tissue lipogenesis and fatty acid oxidation.	SCD5 SCD	8.52e-06	2	102	2	25555387
Pubmed	Stearoyl CoA desaturase is required to produce active, lipid-modified Wnt proteins.	SCD5 SCD	8.52e-06	2	102	2	24055053
Pubmed	Stearoyl-CoA Desaturase-1 Protects Cells against Lipotoxicity-Mediated Apoptosis in Proximal Tubular Cells.	SCD5 SCD	8.52e-06	2	102	2	27834856
Pubmed	Hepatic oleate regulates liver stress response partially through PGC-1α during high-carbohydrate feeding.	SCD5 SCD	8.52e-06	2	102	2	26976120
Pubmed	Stearoyl-CoA desaturase 1 deficiency exacerbates palmitate-induced lipotoxicity by the formation of small lipid droplets in pancreatic β-cells.	SCD5 SCD	8.52e-06	2	102	2	37054998
Pubmed	The UGT2A1/UGT2A2 locus is associated with COVID-19-related loss of smell or taste.	UGT2A2 UGT2A1	8.52e-06	2	102	2	35039640
Pubmed	A CD10-OGP Membrane Peptolytic Signaling Axis in Fibroblasts Regulates Lipid Metabolism of Cancer Stem Cells via SCD1.	SCD5 SCD	8.52e-06	2	102	2	34363355
Pubmed	SCD1 deficiency protects mice against ethanol-induced liver injury.	SCD5 SCD	8.52e-06	2	102	2	27477676
Pubmed	Skin-specific deletion of stearoyl-CoA desaturase-1 alters skin lipid composition and protects mice from high fat diet-induced obesity.	SCD5 SCD	8.52e-06	2	102	2	19429677
Pubmed	Diet-dependent alterations of hepatic Scd1 expression are accompanied by differences in promoter methylation.	SCD5 SCD	8.52e-06	2	102	2	23803969
Pubmed	Stearoyl-CoA Desaturase 1 Is a Key Determinant of Membrane Lipid Composition in 3T3-L1 Adipocytes.	SCD5 SCD	8.52e-06	2	102	2	27632198
Pubmed	Reduced levels of SCD1 accentuate palmitate-induced stress in insulin-producing β-cells.	SCD5 SCD	8.52e-06	2	102	2	20920255
Pubmed	Compensatory increases in tear volume and mucin levels associated with meibomian gland dysfunction caused by stearoyl-CoA desaturase-1 deficiency.	SCD5 SCD	8.52e-06	2	102	2	29463801
Pubmed	Hereditary Absence of Sebaceous Glands in the Mouse.	SCD5 SCD	8.52e-06	2	102	2	17738154
Pubmed	Stearoyl-CoA Desaturase Regulates Angiogenesis and Energy Metabolism in Ischemic Cardiomyocytes.	SCD5 SCD	8.52e-06	2	102	2	36142371
Pubmed	Hepatic lipid partitioning and liver damage in nonalcoholic fatty liver disease: role of stearoyl-CoA desaturase.	SCD5 SCD	8.52e-06	2	102	2	19119140
Pubmed	Sebaceous Gland Atrophy in Psoriasis: An Explanation for Psoriatic Alopecia?	SCD5 SCD	8.52e-06	2	102	2	27312025
Pubmed	Absence of stearoyl-CoA desaturase-1 does not promote DSS-induced acute colitis.	SCD5 SCD	8.52e-06	2	102	2	19695343
Pubmed	Scd1ab-Xyk: a new asebia allele characterized by a CCC trinucleotide insertion in exon 5 of the stearoyl-CoA desaturase 1 gene in mouse.	SCD5 SCD	8.52e-06	2	102	2	15278437
GeneFamily	UDP glucuronosyltransferases	UGT2A2 UGT2A3 UGT2A1	2.76e-04	32	72	3	363
GeneFamily	Fatty acid desaturases	SCD5 SCD	4.31e-04	8	72	2	553
ToppCell	TCGA-Bone_and_Soft_Tissue-Solid_Tissue_Normal\|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9	MGAM DAO DDC UGT2A3 UGT2A1 PKHD1	1.50e-06	154	102	6	89a60a79d07466d7ad05888d10a72d3b1ab384af
ToppCell	TCGA-Bone_and_Soft_Tissue-Solid_Tissue_Normal-Connective_tissue_normal\|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9	MGAM DAO DDC UGT2A3 UGT2A1 PKHD1	1.50e-06	154	102	6	f1fea1a87e977221fa125b62287368be9af4987d
ToppCell	TCGA-Bone_and_Soft_Tissue-Solid_Tissue_Normal-Connective_tissue_normal-Connective_tissue_normal\|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9	MGAM DAO DDC UGT2A3 UGT2A1 PKHD1	1.50e-06	154	102	6	b5604c0b0b9b283352a3f612f40883b9123475d1
ToppCell	TCGA-Bone_and_Soft_Tissue-Solid_Tissue_Normal-Connective_tissue_normal-Connective_tissue_normal-1\|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9	MGAM DAO DDC UGT2A3 UGT2A1 PKHD1	1.50e-06	154	102	6	160b170a3ade8b246843c9854af332475c047ba0
ToppCell	facs-Lung-Endomucin-24m-Myeloid-Myeloid_Dendritic_Type_2\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MED31 CA13 WDHD1 MAPKAPK3 SLC9A7	1.90e-05	142	102	5	0a87c0d74e281da5dc4f59e09a5e99c62b1ea801
ToppCell	TCGA-Head_and_Esophagus-Primary_Tumor-Esophageal_Carcinoma-Adenocarcinoma-3\|TCGA-Head_and_Esophagus / Sample_Type by Project: Shred V9	DIP2C-AS1 DDC AKR7L AKR7A3 MGAM2	2.17e-05	146	102	5	e55b4acecf4e363b5afa287c747c2e58c4597f3a
ToppCell	E18.5-samps-Mesenchymal-Myofibroblast-myofibroblast_-_mature_-_A\|E18.5-samps / Age Group, Lineage, Cell class and subclass	UGT2A2 COL24A1 UGT2A1 HEATR9 TARS1	2.32e-05	148	102	5	5729826e8d45bf995e2efa6707c49e264d12d112
ToppCell	TCGA-Head_and_Esophagus-Primary_Tumor-Esophageal_Carcinoma-Adenocarcinoma\|TCGA-Head_and_Esophagus / Sample_Type by Project: Shred V9	DIP2C-AS1 DDC AKR7L AKR7A3 MGAM2	2.40e-05	149	102	5	92a8931a51db619fb5f0638d319c02e7838f6559
ToppCell	343B-Myeloid-Macrophage-SPP1+_Macrophage_3\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	TRIM72 MGAM KBTBD8 PLCD3 PLXDC2	2.89e-05	155	102	5	c4dc0fa1d0e657753a56939eb4829fb60382c17f
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW19-Mesenchymal\|GW19 / Sample Type, Dataset, Time_group, and Cell type.	TRIM72 FSD2 TRIM65 LNPEP KDM1B	3.27e-05	159	102	5	f34f2729a3872fbb2939e76ad35d7e25f71b8f57
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW19-Mesenchymal-Unfolded_protein_responsible_cell\|GW19 / Sample Type, Dataset, Time_group, and Cell type.	TRIM72 FSD2 TRIM65 LNPEP KDM1B	3.27e-05	159	102	5	929ed98f6c2ad14e8d5af5c6f11a5a3d4b388cf7
ToppCell	droplet-Lung-nan-3m-Myeloid-basophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HVCN1 EML5 SUOX MAPKAPK3 EEF2K	4.37e-05	169	102	5	da607c1d068038d5a3d1117f6aa6e4c6f3552e97
ToppCell	droplet-Lung-nan-3m-Myeloid-Basophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HVCN1 EML5 SUOX MAPKAPK3 EEF2K	4.37e-05	169	102	5	a14b46231e079a0fd9f3ca13d5d48113be76fd0f
ToppCell	390C-Lymphocytic-ILC\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	LRRC66 TNS2 CDAN1 COL24A1 TMEM41B	4.63e-05	171	102	5	70963f79711fe6088d6d01b29206b17ab89e5e73
ToppCell	390C-Lymphocytic-ILC-ILC-2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	LRRC66 TNS2 CDAN1 COL24A1 TMEM41B	4.76e-05	172	102	5	84d16cd7f618c94888920680bdc9e7130d73fd75
ToppCell	facs-SCAT-Fat-24m-Lymphocytic-B_cell\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASA3 HVCN1 SCD SLC9A7 AGBL1	6.06e-05	181	102	5	14faef1dde781d501834379f2a6413e8d6a80b72
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MGAM DDC UGT2A3 UGT2A1 AKR7A3	6.38e-05	183	102	5	d73cac83cde82665f110baad7cf28db75f9ffe52
ToppCell	Control-APC-like-Dendritic_cells\|Control / group, cell type (main and fine annotations)	MGAM ELMO1 PLXDC2 SLC9A7 PREX1	6.38e-05	183	102	5	8f9c8e2436f18ea7c265b08e4e149e19cb513a16
ToppCell	Control-APC-like\|Control / group, cell type (main and fine annotations)	MGAM ELMO1 PLXDC2 SLC9A7 PREX1	6.38e-05	183	102	5	c313ac72cc9fa1583456d452393f61f0a4ca33a8
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Endothelial-blood_vessel_EC\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	A2M CLSTN3 TEK ELMO1 PREX1	7.07e-05	187	102	5	0ef82111b9049cc7ee78d64d240e1f10ab14d6b6
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	A2M ETS2 TEK ELMO1 PREX1	8.40e-05	194	102	5	f76808666fb875fc787751cbfd924d9be20a8192
ToppCell	saliva-Severe-critical_progression_d28-40-Myeloid-Monocytic-Classical_Monocyte-Mono_c3-CD14-VCAN\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	MGAM FNTA ETS2 PREX1 NSMAF	8.40e-05	194	102	5	4eef50c38e6edb2ef2cdcd14eb50805f6cd65bc8
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.2.4\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SCD MAPKAPK3 FHDC1 TMEM41B PRDM6	8.40e-05	194	102	5	54975e663ed4414b99b3c9a1aa6335613946470f
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	ELMO1 COL24A1 MOXD1 PLXDC2 PRDM6	8.40e-05	194	102	5	a3e5a15cf6c1361207f661ee15eb634f77daf1cb
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	A2M ETS2 TEK ELMO1 PREX1	8.40e-05	194	102	5	f5706ab6bc803606c4640ddd606617e4e797ccc9
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	A2M ETS2 TEK ELMO1 PREX1	8.40e-05	194	102	5	a52c5906fce43c2f72cf7e463a3d15cde06431f6
ToppCell	saliva-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TBX21 KBTBD8 RBM26 HVCN1 PRKD3	8.61e-05	195	102	5	a4d36654b968acb1aea252ac203683939461f1d1
ToppCell	saliva-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TBX21 KBTBD8 RBM26 HVCN1 PRKD3	8.61e-05	195	102	5	cd811abd949ef201aef1c8515da5575ab1b1cfea
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ETS2 TEK ELMO1 SSH1 PREX1	8.82e-05	196	102	5	7cbb19108b4553ef60ef5c230a29de1662c02efe
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ETS2 TEK ELMO1 SSH1 PREX1	8.82e-05	196	102	5	4cd1e6b7a791e11a40b19f971b7011bd11fe6273
ToppCell	saliva-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell-B_c02-MS4A1-CD27\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TBX21 KBTBD8 RBM26 ELMO1 PRKD3	8.82e-05	196	102	5	0175b097ad1338a07afebe3b5c7fd0bb0bb950f7
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MGAM DDC UGT2A3 UGT2A1 AKR7A3	8.82e-05	196	102	5	4ebcaac758ed01d918de9c1cd383a84457b615f3
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	ELMO1 COL24A1 MOXD1 PLXDC2 PRDM6	8.82e-05	196	102	5	1450cb69c5bf469e97c03bf1890f6f7c54165b8a
ToppCell	Parenchymal-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	A2M COL24A1 MOXD1 PLXDC2 PRDM6	9.03e-05	197	102	5	44673c38384453207871d3fd8e8ba9093cc06bc5
ToppCell	IPF-Stromal-Myofibroblast\|Stromal / Disease state, Lineage and Cell class	A2M COL24A1 MOXD1 PLXDC2 PRDM6	9.03e-05	197	102	5	f304d42fc4936fe20996e07c8dccc698a6e5e5ef
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	A2M ETS2 TEK ELMO1 PREX1	9.25e-05	198	102	5	07701c73137947ed4a27e225975329235bbb8734
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	A2M ETS2 TEK ELMO1 PREX1	9.25e-05	198	102	5	fa84bf8533d1b91d2c2bcf06b710670605072b89
ToppCell	5'-Adult-SmallIntestine-Epithelial-mature_enterocytic-Enterocyte\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MGAM DDC BTNL3 UGT2A3 AKR7A3	9.25e-05	198	102	5	6e6af8fad09f8e48b3f2ce463d5773b6a69864d1
ToppCell	COVID-19-kidney-Glomerular_EC\|kidney / Disease (COVID-19 only), tissue and cell type	A2M ETS2 TEK ELMO1 PREX1	9.47e-05	199	102	5	fffd2f9042b55531dac4e5b463b5cee80402e7bb
ToppCell	Tracheal-NucSeq-Immune_Lymphocytic-T-T_CD8-CD8\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	RASA3 TBX21 ITGAE HEATR9 PREX1	9.69e-05	200	102	5	5f41906cf1585e09b150a84364d47c3e466dc5b7
ToppCell	Parenchymal-NucSeq-Stromal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	A2M ELMO1 MOXD1 PLXDC2 PRDM6	9.69e-05	200	102	5	cf433f9b43d7db07acaf70e060f8f77c974e72f3
ToppCell	Parenchymal-NucSeq-Stromal-Fibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	A2M ELMO1 MOXD1 PLXDC2 PRDM6	9.69e-05	200	102	5	311fab076f2ceb258e3970eb21e39344b894042a
ToppCell	Parenchymal-NucSeq-Stromal-Fibroblastic-Fibro_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	A2M ELMO1 MOXD1 PLXDC2 PRDM6	9.69e-05	200	102	5	34f52003988ce6329d8deeee1ab875fa77e01e9d
ToppCell	Bronchus_Control_(B.)-Immune-TX-DCs\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	A2M KBTBD8 ELMO1 PLXDC2 PREX1	9.69e-05	200	102	5	e0beacb88bbdc353a3e883171613027feafcf1ef
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MGAM DAO DDC UGT2A3 AKR7A3	9.69e-05	200	102	5	825aad08431dd6b54aa636ace6efc821dfaf8014
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-Mes-Like-Differentiating_AT1\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CCDC57 UGT2A1 PKHD1 AGBL1	1.11e-04	108	102	4	d620f07243c2628494e689bbfabc14c453f4b1f4
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-Mes-Like\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CCDC57 PLCD3 UGT2A1 PKHD1	1.20e-04	110	102	4	c80d1c3df75648e2c8f6832279c2acca63d76681
Disease	Abnormality of the sense of smell, COVID-19 symptoms measurement, ageusia	UGT2A2 UGT2A1	1.16e-05	2	101	2	EFO_0600019, EFO_1001758, HP_0004408
Disease	amino acid metabolic disorder (implicated_via_orthology)	TARS3 TARS1	6.93e-05	4	101	2	DOID:9252 (implicated_via_orthology)
Disease	VACTERL association (implicated_via_orthology)	DYNC2H1 IFT172	1.72e-04	6	101	2	DOID:14679 (implicated_via_orthology)
Disease	skeletal age	CYP11B1 FANCA	2.41e-04	7	101	2	EFO_0020898
Disease	androstenedione measurement	CYP11B1 ELMO1	5.13e-04	10	101	2	EFO_0007972
Disease	Jeune thoracic dystrophy	DYNC2H1 IFT172	6.25e-04	11	101	2	C0265275
Disease	cell growth regulator with EF hand domain protein 1 measurement	CYP11B1 PLXDC2	6.25e-04	11	101	2	EFO_0801461
Disease	restrictive cardiomyopathy (implicated_via_orthology)	SCD5 SCD	8.83e-04	13	101	2	DOID:397 (implicated_via_orthology)
Disease	Short Rib-Polydactyly Syndrome	DYNC2H1 IFT172	8.83e-04	13	101	2	C0036996
Disease	Saldino-Noonan Syndrome	DYNC2H1 IFT172	1.03e-03	14	101	2	C0036069
Disease	Majewski Syndrome	DYNC2H1 IFT172	1.03e-03	14	101	2	C0024507
Disease	inherited metabolic disorder (is_implicated_in)	DDC SUOX	1.18e-03	15	101	2	DOID:655 (is_implicated_in)
Disease	preeclampsia, hypertension, pregnancy-induced	TNS2 PREX1	1.35e-03	16	101	2	EFO_0000668, MONDO_0024664
Disease	MAJOR AFFECTIVE DISORDER 2	DAO DDC	1.53e-03	17	101	2	C1839839
Disease	intraocular pressure measurement	DYNC2H1 KBTBD8 ETS2 FANCA COL24A1 PKHD1 PRRT1	1.86e-03	509	101	7	EFO_0004695
Disease	p-tau:beta-amyloid 1-42 ratio measurement	DDX49 PRDM6	1.91e-03	19	101	2	EFO_0007709
Disease	nicotine dependence symptom count, depressive symptom measurement	DAO PLXDC2 PREX1	2.20e-03	75	101	3	EFO_0007006, EFO_0009262
Disease	progression free survival, ovarian serous carcinoma	MGAM PTCHD4	2.56e-03	22	101	2	EFO_0004920, EFO_1001516
Disease	partial thromboplastin time	PLXDC2 AGBL1	3.05e-03	24	101	2	EFO_0004310
Disease	nephrotic syndrome (biomarker_via_orthology)	A2M DDC	3.05e-03	24	101	2	DOID:1184 (biomarker_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
NSLSEETDHKHDVYW	ZNF286A	181	Q9HBT8
HAVVHLYRDGEDWES	BTNL3	61	Q6UXE8
WSLANHEYFALQHAD	ELMO1	41	Q92556
VVDAFNQAWHLFAHE	AKR7L	311	Q8NHP1
VVDAFNQAWHLVTHE	AKR7A3	311	O95154
QVCDDEWHHYALNLE	CLSTN3	441	Q9BQT9
WLDQVTVNHYHALEN	BTBD16	351	Q32M84
YVANAEAHKRHEWQD	FBXO4	291	Q9UKT5
DGVSYAAELHVVHWN	CA13	111	Q8N1Q1
SHQDSGLITDYRHWQ	DDC	336	P20711
QAKSHRDDRWSDDHY	DISP1	261	Q96F81
RDVFYEVLREWEDHH	CDAN1	456	Q8IWY9
WVSEEHEEAHHTAYL	A2M	436	P01023
ATHDLLYHWQDLEQY	ALG12	41	Q9BV10
QDWHSHDTANAYVQI	AGBL1	196	Q96MI9
QEQWQHYHRSVIEWE	NWD1	156	Q149M9
QAWLTEIHEYAQHDV	RAB26	156	Q9ULW5
WSEFHEDQVDHNSYV	RBM26	271	Q5T8P6
HNRDTWFQLQHVDAD	RASA3	106	Q14644
DWSQQTFDYLLSHVH	DAO	66	P14920
IWTLAARQEHHYQID	FHDC1	116	Q9C0D6
YDSPKARQEVDHHWQ	MAPKAPK3	76	Q16644
VHEFYQDSATWDVHE	MGAM2	691	Q2M2H8
SAHRGLYHDFWEEQV	MSS51	326	Q4VC12
RHFTVVGDDYHAWNI	HVCN1	26	Q96D96
LLHEFYEDNSTWDVH	MGAM	741	O43451
KNDHLQEEDHSGWYH	MFI	116	Q8NCR3
QEEDHSGWYHRIENN	MFI	121	Q8NCR3
FIDEQQILHWQHYSR	MED31	96	Q9Y3C7
CAYSSVQHVEEWHSV	ITGAE	1041	P38570
YWRHQAQQRHKEEEQ	OPA3	101	Q9H6K4
DQYEENSHLTSVPHW	ETS2	176	P15036
ESDDARWEIHAYTHN	PRKD3	856	O94806
LHNHSYASIQSDDLW	LNPEP	576	Q9UIQ6
IVHYADDDWEALIHQ	LNPEP	701	Q9UIQ6
WVRNSDFQLHEIQYH	ALOX12	346	P18054
HDRSDYKHGWQIERE	RNF113A	221	O15541
YELVHTLVAHQGNWE	DSTYK	171	Q6XUX3
DHIHRNDILGEWTYE	LRRC66	526	Q68CR7
EQARHWEQAGEYSRA	IFT172	1281	Q9UG01
EHVYESIIRWFEHEQ	KBTBD8	211	Q8NFY9
QHLWEIYDQDGTLQH	PRDM6	296	Q9NQX0
EGDHLQLSEEWFYAH	PPT1	286	P50897
HLHIWDTAGQDDYDR	RHOD	66	O00212
VDDVWRQTEHDHYPE	DYNC2H1	231	Q8NCM8
RHQHDFDENGIIYWI	HECTD1	1066	Q9ULT8
LHQVSARSWDHNEFF	KDM1B	551	Q8NB78
LSDTERQDFHQWAIH	FANCA	946	O15360
WREQGYEDLHLEVHQ	CYP11B1	56	P15538
EALAESVAQLHSWHY	A3GALT2	211	U3KPV4
EIDHHREQYENLKWT	CCDC57	141	Q2TAC2
VDFLNWEVTDHNLHE	IMP3	16	Q9NV31
ALESNYVSEHLHEWI	NSMAF	496	Q92636
HFHNFISWQDLRAVE	GK5	111	Q6ZS86
HHNSVERYEPERDEW	KEAP1	436	Q14145
VHLIQRFQDEHEDWS	DDX49	236	Q9Y6V7
WDQESAVFHLEHAAN	EEF2K	546	O00418
AHSTHVTNVRWTYDD	EML5	1236	Q05BV3
RNHVDWHSVDEVYLY	DDHD1	346	Q8NEL9
IYAWHFHEQRDCDEH	CST9L	26	Q9H4G1
VVIIIAAQHHENYWD	PRRT1	291	Q99946
WEDHHLQDLQDSYGQ	ATP4A	901	P20648
EEAQAVYWHSSAHIL	TARS3	226	A2RTX5
DEEAQAVYWHSSAHI	TARS1	146	P26639
NHDDWSHDYDNRRDS	RBM7	241	Q9Y580
WDYHAEIQAFGHRLQ	MRPL44	66	Q9H9J2
EHQGRVHYKSWNEDF	TMC3	986	Q7Z5M5
RDAIELNAANYTVWH	FNTA	121	P49354
HHYWEVEVDEHLDYR	FSD2	621	A1L4K1
IQHFLREHYNEWITN	PTCHD4	446	Q6ZW05
QWIYHTHEDAQEARA	PREX1	786	Q8TCU6
EEEVEVDSHAYSHRW	PLXDC2	51	Q6UX71
VVQWDHVHLQDNYNL	PLXDC2	226	Q6UX71
DSRHFNQSEWDRLEH	ST6GALNAC1	306	Q9NSC7
QNDIFEWSRDHRAHH	SCD5	121	Q86SK9
QHTYHVDINDHDWTR	SEMG2	66	Q02383
QADNIFIYESWLIHH	DIP2C-AS1	66	Q8N8Z3
RYSHNFTENWVAGEH	PKHD1	2111	P08F94
DILRQEQYHSWADVA	SPTBN5	491	Q9NRC6
EQYHSWADVARRQEE	SPTBN5	496	Q9NRC6
HEEIESQHSEWFAVY	SESTD1	316	Q86VW0
TDLLAHWNEAYHFIN	SSH1	366	Q8WYL5
IVGQDDHNWRSELYA	ACOT4	321	Q8N9L9
YSVHDEQWHSFAITI	COL24A1	156	Q17RW2
QVWYHGAISRTDAEN	SHF	321	Q7M4L6
WIHAEHLAGYRQQDA	USP51	436	Q70EK9
DGIYWQANLDRFHQH	POLR3C	231	Q9BUI4
VRVIWAYHHEDAGEA	MOXD1	141	Q6UVY6
WIHSYLHRADSNQDS	PLCD3	186	Q8N3E9
EEQFWRSVIFHNHLD	WDHD1	726	O75717
THWHDLYDQREEREA	HEATR9	81	A2RTY3
FQNDVYEWARDHRAH	SCD	146	O00767
AHQQLSEGEHYWEVD	TRIM72	336	Q6ZMU5
VNHYEAWQHIQVTNE	TEK	486	Q02763
SAAHDLTWFQHYSID	UGT2A3	476	Q6UWM9
FWALYAVHNQSHVRE	SUOX	136	P51687
SDQVADLRAEVTHWY	USP34	1231	Q70CQ2
WSQQVERHREHLINY	TMEM41B	186	Q5BJD5
EEDQNEHHWQYFRVG	SLC9A7	546	Q96T83
VRQHEEFIWLHDAYV	SNX32	61	Q86XE0
AQSFQAGHHYWEVRA	TRIM65	376	Q6PJ69
VAAHDLTWFQYHSLD	UGT2A1	476	P0DTE4
FVDVVLVDQHHWRYQ	TBX21	186	Q9UL17
VRWDSYENFNQHHED	TNS2	451	Q63HR2
AAHDLTWFQYHSLDV	UGT2A2	486	P0DTE5
FQTYEHNDWIIHLAG	LMF1	471	Q96S06
TSHEEWSHYNENIRE	LRRIQ3	11	A6PVS8