Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainNPIP

NPIPA1 NPIPA3 NPIPA7 NPIPA2 NPIPB2

5.57e-1214255IPR009443
DomainPRKG1_interact

PPP1R12A PPP1R12B

5.16e-063252IPR031775
DomainMYPT1/MYPT2_chordates

PPP1R12A PPP1R12B

5.16e-063252IPR017401
DomainPRKG1_interact

PPP1R12A PPP1R12B

5.16e-063252PF15898
DomainRRM

ACIN1 SRSF4 SPEN

2.95e-03217253SM00360
DomainRRM_dom

ACIN1 SRSF4 SPEN

3.34e-03227253IPR000504
Domain-

ACIN1 SRSF4 SPEN

4.10e-032442533.30.70.330
DomainNucleotide-bd_a/b_plait

ACIN1 SRSF4 SPEN

4.79e-03258253IPR012677
PathwayREACTOME_RHO_GTPASES_ACTIVATE_ROCKS

PPP1R12A PPP1R12B

1.13e-0419122M27493
PathwayREACTOME_RHO_GTPASES_ACTIVATE_CIT

PPP1R12A PPP1R12B

1.13e-0419122M27489
PathwayREACTOME_RHO_GTPASES_ACTIVATE_PAKS

PPP1R12A PPP1R12B

1.38e-0421122M27494
PathwayREACTOME_RHO_GTPASES_ACTIVATE_PKNS

PPP1R12A PPP1R12B

1.66e-0423122MM15216
PathwayREACTOME_RHO_GTPASES_ACTIVATE_PAKS

PPP1R12A PPP1R12B

1.66e-0423122MM15222
PathwayWP_ENDOPLASMIC_RETICULUM_STRESS_RESPONSE_IN_CORONAVIRUS_INFECTION

PPP1R12A PPP1R12B

6.73e-0446122M39901
PathwayREACTOME_REGULATION_OF_PLK1_ACTIVITY_AT_G2_M_TRANSITION

PPP1R12A PPP1R12B

2.28e-0385122MM14906
PathwayREACTOME_REGULATION_OF_PLK1_ACTIVITY_AT_G2_M_TRANSITION

PPP1R12A PPP1R12B

2.39e-0387122M27194
PathwayREACTOME_RHO_GTPASES_ACTIVATE_PKNS

PPP1R12A PPP1R12B

2.72e-0393122M27487
PathwayKEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION

PPP1R12A PPP1R12B

4.13e-03115122M9387
PathwayKEGG_SPLICEOSOME

ACIN1 SRSF4

5.01e-03127122M2044
PathwayWP_MRNA_PROCESSING

ACIN1 SRSF4 SPEN

5.77e-03451123MM15946
Pubmed

Novel retinal and cone photoreceptor transcripts revealed by human macular expression profiling.

NPIPA1 NPIPA3 NPIPA2

2.08e-09429318055785
Pubmed

Positive selection of a gene family during the emergence of humans and African apes.

NPIPA1 NPIPA8

6.71e-07229211586358
Pubmed

Pharmacomechanical coupling: the role of calcium, G-proteins, kinases and phosphatases.

PPP1R12A PPP1R12B

6.71e-07229210087910
Pubmed

Kinases, myosin phosphatase and Rho proteins: curiouser and curiouser.

PPP1R12A PPP1R12B

6.71e-07229210200412
Pubmed

Heart-specific small subunit of myosin light chain phosphatase activates rho-associated kinase and regulates phosphorylation of myosin phosphatase target subunit 1.

PPP1R12A PPP1R12B

2.01e-06329220801872
Pubmed

Regulation of myosin phosphatase by a specific interaction with cGMP- dependent protein kinase Ialpha.

PPP1R12A PPP1R12B

2.01e-06329210567269
Pubmed

Identification, characterization, and functional analysis of heart-specific myosin light chain phosphatase small subunit.

PPP1R12A PPP1R12B

4.02e-06429211067852
Pubmed

PDZ Domain-mediated interaction of interleukin-16 precursor proteins with myosin phosphatase targeting subunits.

PPP1R12A PPP1R12B

6.70e-06529212923170
Pubmed

Loss-of-Function Variants in PPP1R12A: From Isolated Sex Reversal to Holoprosencephaly Spectrum and Urogenital Malformations.

PPP1R12A PPP1R12B

6.70e-06529231883643
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

GON4L NEPRO PPAN SPEN ARGLU1 PPP1R12A PPP1R12B RSRC1

2.21e-05149729831527615
Pubmed

RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.

ACIN1 PPAN SRSF4 TARS2 ARGLU1 RSRC1

2.31e-0571329629802200
Pubmed

Characterizing ZC3H18, a Multi-domain Protein at the Interface of RNA Production and Destruction Decisions.

ACIN1 PPAN SRSF4 SPEN ARGLU1 RSRC1

2.66e-0573129629298432
Pubmed

Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.

KANSL1L PPAN MAGEE1 TP53INP2

4.09e-0523329437704626
Pubmed

Interplay between Polo kinase, LKB1-activated NUAK1 kinase, PP1βMYPT1 phosphatase complex and the SCFβTrCP E3 ubiquitin ligase.

PPP1R12A PPP1R12B

4.41e-051229224785407
Pubmed

SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.

ACIN1 SRSF4 SPEN ARGLU1

5.46e-0525129431076518
Pubmed

Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.

ACIN1 NEPRO PPAN SRSF4 PPP1R12A RSRC1

6.03e-0584729635850772
Pubmed

SNIP1 Recruits TET2 to Regulate c-MYC Target Genes and Cellular DNA Damage Response.

ACIN1 PPAN SRSF4 ARGLU1

6.16e-0525929430404004
Pubmed

TRIM21-mediated proteasomal degradation of SAMHD1 regulates its antiviral activity.

GON4L DNPEP

1.14e-041929231797533
Pubmed

Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexes.

ACIN1 SRSF4 ARGLU1

1.21e-0411529317332742
Pubmed

Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation.

ACIN1 SRSF4 PPP1R12A PPP1R12B

2.21e-0436129430344098
Pubmed

Secretory pathway calcium ATPase 1 (SPCA1) controls mouse neural tube closure by regulating cytoskeletal dynamics.

BMP6 PPP1R12A

2.69e-042929230228103
Pubmed

The cell proliferation antigen Ki-67 organises heterochromatin.

ACIN1 PPAN SRSF4 SPEN

3.58e-0441029426949251
Pubmed

Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.

ACIN1 PPAN SRSF4 ARGLU1 PPP1R12A PPP1R12B

4.91e-04124729627684187
Pubmed

A comprehensive resource of interacting protein regions for refining human transcription factor networks.

ACIN1 NEPRO PPP1R12A

5.36e-0419129320195357
Pubmed

In vitro nuclear interactome of the HIV-1 Tat protein.

ACIN1 NCAPG SPEN

5.70e-0419529319454010
Pubmed

Large-scale mapping of human protein-protein interactions by mass spectrometry.

ACIN1 PPAN NCAPG SRSF4 PPP1R12A DNPEP

5.73e-04128429617353931
Pubmed

Dynamic protein-protein interaction wiring of the human spliceosome.

ACIN1 SRSF4 ARGLU1

5.87e-0419729322365833
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

EI24 ACIN1 SRSF4 SPEN ARGLU1 RSRC1

5.97e-04129429630804502
Pubmed

PINK1 Content in Mitochondria is Regulated by ER-Associated Degradation.

ACIN1 MAGEE1 SRSF4 PPP1R12A

6.32e-0447729431300519
Pubmed

BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.

ACIN1 PPAN NCAPG SRSF4 ARGLU1 RSRC1

6.57e-04131829630463901
Pubmed

Phosphoproteome analysis of the human mitotic spindle.

NEPRO PPAN NCAPG

7.06e-0421029316565220
Pubmed

SIK2 orchestrates actin-dependent host response upon Salmonella infection.

PPP1R12A PPP1R12B

8.02e-045029233947818
Cytoband16p13.11

NPIPA1 NPIPA3 NPIPA2

3.98e-072329316p13.11
CytobandEnsembl 112 genes in cytogenetic band chr16p13

NPIPA1 NPIPA3 NPIPA7 NPIPA2 NPIPB2

6.64e-06426295chr16p13
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

PPP1R12A PPP1R12B

5.17e-03181112694
GeneFamilyRNA binding motif containing

SRSF4 SPEN

7.08e-03213112725
GeneFamilyAnkyrin repeat domain containing

PPP1R12A PPP1R12B

9.06e-03242112403
CoexpressionGSE17721_POLYIC_VS_CPG_6H_BMDC_UP

EI24 ACIN1 RNF128 SPEN ARGLU1

1.73e-06200275M3943
CoexpressionGSE29617_DAY3_VS_DAY7_TIV_FLU_VACCINE_PBMC_2008_DN

NPIPA1 GON4L SRSF4 ARGLU1

4.21e-05191274M4935
Diseasephosphatidylcholine 40:7 measurement

NPIPA1 NPIPA2

5.34e-0513252EFO_0021477
Diseaselysophosphatidylcholine 20:3 measurement

NPIPA1 NPIPA2

5.27e-0440252EFO_0010362
Diseaseretinal nerve fibre layer thickness measurement

NPIPA1 NPIPA2

6.09e-0443252EFO_0600004
Diseasecholesteryl ester 20:3 measurement

NPIPA1 NPIPA2

7.91e-0449252EFO_0010347
Diseasetriglycerides to total lipids in medium LDL percentage

NPIPA1 NPIPA2

8.23e-0450252EFO_0022334
Diseasetriglycerides to total lipids in large LDL percentage

NPIPA1 NPIPA2

8.57e-0451252EFO_0022331
Diseasetriglycerides to total lipids in small VLDL percentage

NPIPA1 NPIPA2

1.11e-0358252EFO_0022338
Diseaseretinal layer thickness measurement

NPIPA1 NPIPA2

1.18e-0360252EFO_0600002
Diseasegastric carcinoma

GON4L NPIPB2

2.58e-0389252EFO_0000178
Diseasecholesteryl ester measurement, intermediate density lipoprotein measurement

NPIPA1 NPIPA2

2.87e-0394252EFO_0008595, EFO_0010351
Diseaselipid measurement, intermediate density lipoprotein measurement

NPIPA1 NPIPA2

2.99e-0396252EFO_0004529, EFO_0008595
Diseasephospholipid measurement, intermediate density lipoprotein measurement

NPIPA1 NPIPA2

3.18e-0399252EFO_0004639, EFO_0008595
Diseasetotal cholesterol measurement, intermediate density lipoprotein measurement

NPIPA1 NPIPA2

3.18e-0399252EFO_0004574, EFO_0008595
Diseasefree cholesterol measurement, intermediate density lipoprotein measurement

NPIPA1 NPIPA2

3.50e-03104252EFO_0008591, EFO_0008595
Diseaseneuroblastoma

KANSL1L RSRC1

4.33e-03116252EFO_0000621
Diseaselymphocyte measurement

PPAN DNPEP

4.41e-03117252EFO_0803546
DiseaseIntellectual Disability

GON4L ACIN1 PPP1R12A

6.20e-03447253C3714756

Protein segments in the cluster

PeptideGeneStartEntry
RRSSRVRQARAAKLS

ACIN1

226

Q9UKV3
RVKRRSRRSQVGFQQ

DNPEP

111

Q9ULA0
SKRNRRRESRSRSRS

ARGLU1

46

Q9NWB6
STDVQQRARRSNRRR

NPIPA1

81

Q9UND3
SKRKFSGQQRRRRNS

DEPDC5

1516

O75140
RIQNSSRNTARRRLR

KANSL1L

751

A0AUZ9
QNSRRRRRRVAKATA

MAGEE1

6

Q9HCI5
RRVQQKSGDRTSRAR

FAM205C

51

A6NFA0
STDVQQRARRSNRRR

NPIPA3

81

F8WFD2
TDVQQRARRSNRRRQ

NPIPA2

101

E9PIF3
RQALSSSRRQRARNM

GASK1A

61

Q9UFP1
RRRRASSVLAQRRAQ

EI24

41

O14681
RNNHRARNKRGSRAR

GON4L

1586

Q3T8J9
RTTRSASSRRRQQSR

BMP6

371

P22004
ASSRRRQQSRNRSTQ

BMP6

376

P22004
RRNRERNSRSGKTRC

KHDC1

51

Q4VXA5
STDVQQRARRSNRRR

NPIPA7

81

E9PJI5
STDVQQRARRSNRRR

NPIPA8

81

P0DM63
QSKRTVNIRTRDNRR

TARS2

676

Q9BW92
RSQEKSLRQSRSRSR

SRSF4

321

Q08170
LRQRRSQNKFLRRQR

NEPRO

441

Q6NW34
ARRLRNARAQSRKQR

RNF128

231

Q8TEB7
RGQRKVTVSARTNRR

NCAPG

951

Q9BPX3
GRQKTTRSRRKRNTN

SPEN

2331

Q96T58
RQNRARESRPRRSKN

TP53INP2

191

Q8IXH6
RQRRQSRSPNKERDR

SRRM5

531

B3KS81
RSRHQKRARAQAQLR

PPAN

6

Q9NQ55
STDVQQRARRSNRRR

NPIPB2

81

A6NJ64
VQRSRSKSRTRRSRS

RSRC1

96

Q96IZ7
QRKARSRQARQSRRS

PPP1R12A

681

O14974
LRKARSRQARQTRRS

PPP1R12B

631

O60237