Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	histone deacetylase activity	MIER2 HDAC5 HDAC4	1.41e-04	24	85	3	GO:0004407
GeneOntologyMolecularFunction	protein lysine deacetylase activity	MIER2 HDAC5 HDAC4	1.60e-04	25	85	3	GO:0033558
GeneOntologyBiologicalProcess	positive regulation of transcription by RNA polymerase II	SETX HDAC5 HDAC4 INHBA GLI2 ASXL3 AKNA ZFHX3 POU5F1 CHD6 GRIN1 SPAG8 SIX3 ZBED3 OLIG2 TOX2 POU2F3 HOXA1	1.38e-05	1390	86	18	GO:0045944
GeneOntologyCellularComponent	chromatin	KDM4D HDAC5 HDAC4 MNX1 ZFHX3 POU5F1 CHD6 BCL7A SIX3 ZBED3 OLIG2 POU2F3 RHNO1 CIC SLX4 FOXK1 HOXA1	8.15e-05	1480	85	17	GO:0000785
Domain	Hist_deacetylase_Gln_rich_N	HDAC5 HDAC4	6.12e-05	3	85	2	IPR024643
Domain	HDAC4_Gln	HDAC5 HDAC4	6.12e-05	3	85	2	PF12203
Domain	Histone_deAcase_II_euk	HDAC5 HDAC4	1.22e-04	4	85	2	IPR017320
Domain	Homeobox	MNX1 ZFHX3 POU5F1 SIX3 POU2F3 HOXA1	6.95e-04	234	85	6	PF00046
Domain	PH_dom-like	PHLDB1 ARHGAP23 FRMPD1 OSBPL5 OBSCN ANKS1B TRIOBP PLCB3	7.12e-04	426	85	8	IPR011993
Domain	HOMEOBOX_1	MNX1 ZFHX3 POU5F1 SIX3 POU2F3 HOXA1	7.27e-04	236	85	6	PS00027
Domain	HOX	MNX1 ZFHX3 POU5F1 SIX3 POU2F3 HOXA1	7.43e-04	237	85	6	SM00389
Domain	HOMEOBOX_2	MNX1 ZFHX3 POU5F1 SIX3 POU2F3 HOXA1	7.76e-04	239	85	6	PS50071
Domain	Homeobox_dom	MNX1 ZFHX3 POU5F1 SIX3 POU2F3 HOXA1	7.76e-04	239	85	6	IPR001356
Domain	Homeodomain-like	MIER2 MNX1 ZFHX3 POU5F1 SIX3 POU2F3 HOXA1	7.93e-04	332	85	7	IPR009057
Domain	Hist_deacetyl	HDAC5 HDAC4	1.10e-03	11	85	2	PF00850
Domain	His_deacetylse_dom	HDAC5 HDAC4	1.10e-03	11	85	2	IPR023801
Domain	-	HDAC5 HDAC4	1.10e-03	11	85	2	3.40.800.20
Domain	His_deacetylse	HDAC5 HDAC4	1.10e-03	11	85	2	IPR000286
Domain	Ldl_recept_a	LDLRAD2 CD320 SSPOP	1.12e-03	45	85	3	PF00057
Domain	-	LDLRAD2 CD320 SSPOP	1.20e-03	46	85	3	4.10.400.10
Domain	LDLRA_2	LDLRAD2 CD320 SSPOP	1.44e-03	49	85	3	PS50068
Domain	LDrepeatLR_classA_rpt	LDLRAD2 CD320 SSPOP	1.44e-03	49	85	3	IPR002172
Domain	LDLa	LDLRAD2 CD320 SSPOP	1.44e-03	49	85	3	SM00192
Domain	Homeobox_CS	MNX1 ZFHX3 POU5F1 POU2F3 HOXA1	1.60e-03	186	85	5	IPR017970
Domain	-	MNX1 ZFHX3 POU5F1 SIX3 POU2F3 HOXA1	1.84e-03	283	85	6	1.10.10.60
Domain	-	PHLDB1 ARHGAP23 OSBPL5 OBSCN ANKS1B TRIOBP PLCB3	2.03e-03	391	85	7	2.30.29.30
Domain	POU	POU5F1 POU2F3	2.36e-03	16	85	2	SM00352
Domain	POU_2	POU5F1 POU2F3	2.36e-03	16	85	2	PS00465
Domain	POU_dom	POU5F1 POU2F3	2.36e-03	16	85	2	IPR000327
Domain	POU_3	POU5F1 POU2F3	2.36e-03	16	85	2	PS51179
Domain	Pou	POU5F1 POU2F3	2.36e-03	16	85	2	PF00157
Domain	POU_1	POU5F1 POU2F3	2.36e-03	16	85	2	PS00035
Domain	POU	POU5F1 POU2F3	2.66e-03	17	85	2	IPR013847
Domain	WAP_dom	WFIKKN1 CD320	4.46e-03	22	85	2	IPR008197
Domain	PAS_fold_3	PER3 KCNH3	4.87e-03	23	85	2	IPR013655
Domain	PAS_3	PER3 KCNH3	4.87e-03	23	85	2	PF08447
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PRR12 NHSL1 GAS2L1 SCAF1 KIAA0930 PHLDB1 AATK INF2 ZNF516 OSBPL5 OBSCN AKNA BCL7A ZBED3 CIC FOXK1 KCNH3	1.85e-09	1105	87	17	35748872
Pubmed	Interaction network of human early embryonic transcription factors.	PRR12 HDAC5 HDAC4 MNX1 ASXL3 ZNF516 ZFHX3 BCL7A SLX4 FOXK1	1.94e-08	351	87	10	38297188
Pubmed	Small ubiquitin-like Modifier (SUMO) modification inhibits GLI2 protein transcriptional activity in vitro and in vivo.	HDAC5 HDAC4 MNX1 GLI2	3.59e-08	14	87	4	22549777
Pubmed	A census of human transcription factors: function, expression and evolution.	MNX1 GLI2 AKNA ZFHX3 POU5F1 SIX3 ZBED3 OLIG2 TOX2 POU2F3 CIC FOXK1 HOXA1	4.14e-07	908	87	13	19274049
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	MIER2 PRR12 KIAA0930 PER3 ARHGAP23 IP6K1 MON1B NEURL4 SLX4 MAST3	4.51e-07	493	87	10	15368895
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	KLHL29 PHLDB1 HDAC5 DLGAP4 FRMPD1 CHD6 CROCC SRRM2 SLC12A5	8.64e-07	407	87	9	12693553
Pubmed	Transcriptional Networks Controlled by NKX2-1 in the Development of Forebrain GABAergic Neurons.	GLI2 ZNF516 SIX3 OLIG2	3.12e-06	40	87	4	27657450
Pubmed	Centrosomal protein CP110 controls maturation of the mother centriole during cilia biogenesis.	MNX1 CROCC OLIG2	4.25e-06	13	87	3	26965371
Pubmed	Suppressor of fused and Spop regulate the stability, processing and function of Gli2 and Gli3 full-length activators but not their repressors.	MNX1 GLI2 OLIG2	5.39e-06	14	87	3	20463034
Pubmed	Complex interactions between genes controlling trafficking in primary cilia.	MNX1 GLI2 OLIG2	5.39e-06	14	87	3	21552265
Pubmed	Class IIa histone deacetylases link cAMP signaling to the myelin transcriptional program of Schwann cells.	HDAC5 HDAC4	6.19e-06	2	87	2	29472387
Pubmed	Disruption of the Class IIa HDAC Corepressor Complex Increases Energy Expenditure and Lipid Oxidation.	HDAC5 HDAC4	6.19e-06	2	87	2	27626651
Pubmed	Nitric oxide modulates chromatin folding in human endothelial cells via protein phosphatase 2A activation and class II histone deacetylases nuclear shuttling.	HDAC5 HDAC4	6.19e-06	2	87	2	17975112
Pubmed	Nuclear calcium signaling regulates nuclear export of a subset of class IIa histone deacetylases following synaptic activity.	HDAC5 HDAC4	6.19e-06	2	87	2	23364788
Pubmed	Class IIa HDACs regulate learning and memory through dynamic experience-dependent repression of transcription.	HDAC5 HDAC4	6.19e-06	2	87	2	31375688
Pubmed	Class II histone deacetylases downregulate GLUT4 transcription in response to increased cAMP signaling in cultured adipocytes and fasting mice.	HDAC5 HDAC4	6.19e-06	2	87	2	22403301
Pubmed	Control of cardiac growth by histone acetylation/deacetylation.	HDAC5 HDAC4	6.19e-06	2	87	2	16397154
Pubmed	A direct HDAC4-MAP kinase crosstalk activates muscle atrophy program.	HDAC4 MAP3K2	6.19e-06	2	87	2	22658415
Pubmed	The ciliary phosphatidylinositol phosphatase Inpp5e plays positive and negative regulatory roles in Shh signaling.	MNX1 GLI2 OLIG2	8.27e-06	16	87	3	31964774
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	NHSL1 STOX2 KIAA0930 PHLDB1 SETX HDAC4 TESK2 SRRM2 CIC FOXK1 MAP3K2	1.02e-05	861	87	11	36931259
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	PRR12 HDAC5 ZNF516 RUSC1 ZFHX3 POU5F1 CHD6 CIC	1.04e-05	418	87	8	34709266
Pubmed	All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3.	MNX1 GLI2 OLIG2	1.20e-05	18	87	3	14723851
Pubmed	Cell Cycle-Related Kinase (CCRK) regulates ciliogenesis and Hedgehog signaling in mice.	MNX1 GLI2 OLIG2	1.42e-05	19	87	3	28817564
Pubmed	The histone demethylase Kdm6b regulates subtype diversification of mouse spinal motor neurons during development.	MNX1 ZFHX3 OLIG2	1.67e-05	20	87	3	35177643
Pubmed	OCT3/4 regulates transcription of histone deacetylase 4 (Hdac4) in mouse embryonic stem cells.	HDAC4 POU5F1	1.85e-05	3	87	2	20506506
Pubmed	NOX2-dependent ROS is required for HDAC5 nuclear efflux and contributes to HDAC4 nuclear efflux during intense repetitive activity of fast skeletal muscle fibers.	HDAC5 HDAC4	1.85e-05	3	87	2	22648949
Pubmed	Identification of a signal-responsive nuclear export sequence in class II histone deacetylases.	HDAC5 HDAC4	1.85e-05	3	87	2	11509672
Pubmed	G betagamma binds histone deacetylase 5 (HDAC5) and inhibits its transcriptional co-repression activity.	HDAC5 HDAC4	1.85e-05	3	87	2	16221676
Pubmed	Neddylation Regulates Class IIa and III Histone Deacetylases to Mediate Myoblast Differentiation.	HDAC5 HDAC4	1.85e-05	3	87	2	34502418
Pubmed	Histone deacetylase 5 is a phosphorylation substrate of protein kinase D in osteoclasts.	HDAC5 HDAC4	1.85e-05	3	87	2	35318161
Pubmed	Dephosphorylation at a conserved SP motif governs cAMP sensitivity and nuclear localization of class IIa histone deacetylases.	HDAC5 HDAC4	1.85e-05	3	87	2	23297420
Pubmed	A FAK/HDAC5 signaling axis controls osteocyte mechanotransduction.	HDAC5 HDAC4	1.85e-05	3	87	2	32612176
Pubmed	Gene expression profiling reveals the heterogeneous transcriptional activity of Oct3/4 and its possible interaction with Gli2 in mouse embryonic stem cells.	GLI2 POU5F1	1.85e-05	3	87	2	24121003
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	KLHL29 PHLDB1 HDAC4 TECPR2 INF2 GLI2 FRMPD1 OSBPL5 OBSCN TRIOBP ZFHX3 CHD6 CROCC SSPOP	1.89e-05	1489	87	14	28611215
Pubmed	Protein kinase A acts at the basal body of the primary cilium to prevent Gli2 activation and ventralization of the mouse neural tube.	MNX1 GLI2 OLIG2	1.95e-05	21	87	3	22007132
Pubmed	Transduction of graded Hedgehog signaling by a combination of Gli2 and Gli3 activator functions in the developing spinal cord.	MNX1 GLI2 OLIG2	2.25e-05	22	87	3	15215207
Pubmed	Mouse hitchhiker mutants have spina bifida, dorso-ventral patterning defects and polydactyly: identification of Tulp3 as a novel negative regulator of the Sonic hedgehog pathway.	MNX1 GLI2 OLIG2	2.25e-05	22	87	3	19223390
Pubmed	Broad-minded links cell cycle-related kinase to cilia assembly and hedgehog signal transduction.	MNX1 GLI2 OLIG2	2.25e-05	22	87	3	20159594
Pubmed	Genome-scale study of transcription factor expression in the branching mouse lung.	MNX1 GLI2 ZFHX3 HOXA1	2.48e-05	67	87	4	22711520
Pubmed	Molecular mechanism of transcriptional repression of AhR repressor involving ANKRA2, HDAC4, and HDAC5.	HDAC5 HDAC4	3.70e-05	4	87	2	17949687
Pubmed	Exercise-induced GLUT4 transcription via inactivation of HDAC4/5 in mouse skeletal muscle in an AMPKα2-dependent manner.	HDAC5 HDAC4	3.70e-05	4	87	2	28688716
Pubmed	Olig2 and Ngn2 function in opposition to modulate gene expression in motor neuron progenitor cells.	MNX1 OLIG2	3.70e-05	4	87	2	15655114
Pubmed	Up-regulation of HO-1 promotes resistance of B-cell acute lymphocytic leukemia cells to HDAC4/5 inhibitor LMK-235 via the Smad7 pathway.	HDAC5 HDAC4	3.70e-05	4	87	2	29886060
Pubmed	Changes in Hox1.6, c-jun, and Oct-3 gene expressions are associated with teratocarcinoma F9 cell differentiation in three different ways of induction.	POU5F1 HOXA1	3.70e-05	4	87	2	8453995
Pubmed	SIK1 is a class II HDAC kinase that promotes survival of skeletal myocytes.	HDAC5 HDAC4	3.70e-05	4	87	2	17468767
Pubmed	PTHrP targets HDAC4 and HDAC5 to repress chondrocyte hypertrophy.	HDAC5 HDAC4	3.70e-05	4	87	2	30843886
Pubmed	SIKs control osteocyte responses to parathyroid hormone.	HDAC5 HDAC4	3.70e-05	4	87	2	27759007
Pubmed	Class IIa histone deacetylases: conducting development and differentiation.	HDAC5 HDAC4	3.70e-05	4	87	2	19412888
Pubmed	mHDA1/HDAC5 histone deacetylase interacts with and represses MEF2A transcriptional activity.	HDAC5 HDAC4	3.70e-05	4	87	2	10748098
Pubmed	Class II HDACs mediate CaMK-dependent signaling to NRSF in ventricular myocytes.	HDAC5 HDAC4	3.70e-05	4	87	2	17011572
Pubmed	HDAC4 and 5 repression of TBX5 is relieved by protein kinase D1.	HDAC5 HDAC4	3.70e-05	4	87	2	31784580
Pubmed	GLI2-specific transcriptional activation of the bone morphogenetic protein/activin antagonist follistatin in human epidermal cells.	INHBA GLI2	3.70e-05	4	87	2	18319260
Pubmed	Autism candidate gene DIP2A regulates spine morphogenesis via acetylation of cortactin.	HDAC5 HDAC4 GRIN1	4.73e-05	28	87	3	31600191
Pubmed	Distinct effects of Hedgehog signaling on neuronal fate specification and cell cycle progression in the embryonic mouse retina.	GLI2 SIX3 OLIG2	5.27e-05	29	87	3	19474320
Pubmed	Single cell transcriptomics reveals spatial and temporal dynamics of gene expression in the developing mouse spinal cord.	MNX1 ZFHX3 OLIG2	5.27e-05	29	87	3	30846445
Pubmed	Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components.	MNX1 GLI2 OLIG2	5.27e-05	29	87	3	21209331
Pubmed	Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus.	MNX1 ZFHX3 SIX3 CIC FOXK1 HOXA1	5.34e-05	263	87	6	20932939
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	STOX2 SETX TECPR2 ZNF516 PHRF1 OSBPL5 AKNA TRIOBP	5.54e-05	529	87	8	14621295
Pubmed	Floor plate-derived sonic hedgehog regulates glial and ependymal cell fates in the developing spinal cord.	MNX1 GLI2 OLIG2	5.85e-05	30	87	3	23482494
Pubmed	Regulation of skeletal myogenesis by association of the MEF2 transcription factor with class II histone deacetylases.	HDAC5 HDAC4	6.16e-05	5	87	2	10983972
Pubmed	Functional interaction between class II histone deacetylases and ICP0 of herpes simplex virus type 1.	HDAC5 HDAC4	6.16e-05	5	87	2	15194749
Pubmed	A novel corepressor, BCoR-L1, represses transcription through an interaction with CtBP.	HDAC5 HDAC4	6.16e-05	5	87	2	17379597
Pubmed	Regulation of MEF2 by histone deacetylase 4- and SIRT1 deacetylase-mediated lysine modifications.	HDAC5 HDAC4	6.16e-05	5	87	2	16166628
Pubmed	Immediate effects of a single exercise bout on protein O-GlcNAcylation and chromatin regulation of cardiac hypertrophy.	HDAC5 HDAC4	6.16e-05	5	87	2	23624624
Pubmed	HDAC4 integrates PTH and sympathetic signaling in osteoblasts.	HDAC5 HDAC4	6.16e-05	5	87	2	24934156
Pubmed	CaM kinase II selectively signals to histone deacetylase 4 during cardiomyocyte hypertrophy.	HDAC5 HDAC4	6.16e-05	5	87	2	16767219
Pubmed	Transcriptional activation of hypoxia-inducible factor-1alpha by HDAC4 and HDAC5 involves differential recruitment of p300 and FIH-1.	HDAC5 HDAC4	6.16e-05	5	87	2	19071119
Pubmed	Myocyte enhancer factor 2 and class II histone deacetylases control a gender-specific pathway of cardioprotection mediated by the estrogen receptor.	HDAC5 HDAC4	6.16e-05	5	87	2	19893013
Pubmed	Membralin deficiency dysregulates astrocytic glutamate homeostasis leading to ALS-like impairment.	MNX1 OLIG2	6.16e-05	5	87	2	31112137
Pubmed	Activation of the myocyte enhancer factor-2 transcription factor by calcium/calmodulin-dependent protein kinase-stimulated binding of 14-3-3 to histone deacetylase 5.	HDAC5 HDAC4	6.16e-05	5	87	2	11114197
Pubmed	Nε-lysine acetylation determines dissociation from GAP junctions and lateralization of connexin 43 in normal and dystrophic heart.	HDAC5 HDAC4	6.16e-05	5	87	2	21282606
Pubmed	The histone deacetylase-3 complex contains nuclear receptor corepressors.	HDAC5 HDAC4	6.16e-05	5	87	2	10860984
Pubmed	The zinc finger SET domain gene Prdm14 is overexpressed in lymphoblastic lymphomas with retroviral insertions at Evi32.	SLCO5A1 POU5F1	6.16e-05	5	87	2	19043588
Pubmed	Histone deacetylase 5 acquires calcium/calmodulin-dependent kinase II responsiveness by oligomerization with histone deacetylase 4.	HDAC5 HDAC4	6.16e-05	5	87	2	18332106
Pubmed	Epigenetic silencing of CD8 genes by ThPOK-mediated deacetylation during CD4 T cell differentiation.	HDAC5 HDAC4	6.16e-05	5	87	2	22730529
Pubmed	Altered interaction of HDAC5 with GATA-1 during MEL cell differentiation.	HDAC5 HDAC4	6.16e-05	5	87	2	14668799
Pubmed	Impact of cytosine methylation on DNA binding specificities of human transcription factors.	MNX1 GLI2 POU5F1 SIX3 OLIG2 POU2F3 FOXK1 HOXA1	6.74e-05	544	87	8	28473536
Pubmed	NLRP14 deficiency causes female infertility with oocyte maturation defects and early embryonic arrest by impairing cytoplasmic UHRF1 abundance.	ZSCAN5C TLE6 ZBED3	7.12e-05	32	87	3	38060382
Pubmed	Tubby-like protein 3 (TULP3) regulates patterning in the mouse embryo through inhibition of Hedgehog signaling.	MNX1 GLI2 OLIG2	7.12e-05	32	87	3	19286674
Pubmed	FKBP8 cell-autonomously controls neural tube patterning through a Gli2- and Kif3a-dependent mechanism.	MNX1 GLI2 OLIG2	8.55e-05	34	87	3	18590716
Pubmed	The functional interactome landscape of the human histone deacetylase family.	MIER2 HDAC5 HDAC4 ZNF516 CROCC SRRM2	8.98e-05	289	87	6	23752268
Pubmed	HDAC5-mTORC1 Interaction in Differential Regulation of Ghrelin and Nucleobindin 2 (NUCB2)/Nesfatin-1.	HDAC5 HDAC4	9.22e-05	6	87	2	26357899
Pubmed	A dynamic role for HDAC7 in MEF2-mediated muscle differentiation.	HDAC5 HDAC4	9.22e-05	6	87	2	11279209
Pubmed	Signal-dependent activation of the MEF2 transcription factor by dissociation from histone deacetylases.	HDAC5 HDAC4	9.22e-05	6	87	2	10737771
Pubmed	Protein phosphatase 2A controls the activity of histone deacetylase 7 during T cell apoptosis and angiogenesis.	HDAC5 HDAC4	9.22e-05	6	87	2	18339811
Pubmed	Class II histone deacetylases are directly recruited by BCL6 transcriptional repressor.	HDAC5 HDAC4	9.22e-05	6	87	2	11929873
Pubmed	Control of MEF2 transcriptional activity by coordinated phosphorylation and sumoylation.	HDAC5 HDAC4	9.22e-05	6	87	2	16356933
Pubmed	Olig2-positive progenitors in the embryonic spinal cord give rise not only to motoneurons and oligodendrocytes, but also to a subset of astrocytes and ependymal cells.	MNX1 OLIG2	9.22e-05	6	87	2	16581057
Pubmed	AATYK is a Novel Regulator of Oligodendrocyte Differentiation and Myelination.	AATK OLIG2	9.22e-05	6	87	2	29556912
Pubmed	New role for hPar-1 kinases EMK and C-TAK1 in regulating localization and activity of class IIa histone deacetylases.	HDAC5 HDAC4	9.22e-05	6	87	2	16980613
Pubmed	SUMO modification regulates the transcriptional repressor function of aryl hydrocarbon receptor repressor.	HDAC5 HDAC4	9.22e-05	6	87	2	19251700
Pubmed	Sexually dimorphic expression of protease nexin-1 and vanin-1 in the developing mouse gonad prior to overt differentiation suggests a role in mammalian sexual development.	GLI2 POU5F1	9.22e-05	6	87	2	10888606
Pubmed	The tumor suppressor kinase LKB1 activates the downstream kinases SIK2 and SIK3 to stimulate nuclear export of class IIa histone deacetylases.	HDAC5 HDAC4	9.22e-05	6	87	2	23393134
Pubmed	BRCT domains of the DNA damage checkpoint proteins TOPBP1/Rad4 display distinct specificities for phosphopeptide ligands.	BRIP1 RHNO1	9.22e-05	6	87	2	30295604
Pubmed	A genetic compensatory mechanism regulated by Jun and Mef2d modulates the expression of distinct class IIa Hdacs to ensure peripheral nerve myelination and repair.	HDAC5 HDAC4	9.22e-05	6	87	2	35076395
Pubmed	PI(3,5)P2 biosynthesis regulates oligodendrocyte differentiation by intrinsic and extrinsic mechanisms.	MNX1 OLIG2	9.22e-05	6	87	2	27008179
Pubmed	Histone deacetylase 3 binds to and regulates the GCMa transcription factor.	HDAC5 HDAC4	9.22e-05	6	87	2	16528103
Pubmed	Myogenin and class II HDACs control neurogenic muscle atrophy by inducing E3 ubiquitin ligases.	HDAC5 HDAC4	9.22e-05	6	87	2	20887891
Pubmed	Class II histone deacetylases confer signal responsiveness to the ankyrin-repeat proteins ANKRA2 and RFXANK.	HDAC5 HDAC4	9.22e-05	6	87	2	16236793
Pubmed	Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway.	HDAC5 HDAC4	9.22e-05	6	87	2	10640275
Interaction	SOX15 interactions	PRR12 MNX1 PLCB3 POU5F1 BCL7A SRRM2 CIC FOXK1	1.08e-07	141	82	8	int:SOX15
Interaction	TBR1 interactions	PRR12 MNX1 ZFHX3 BCL7A CIC FOXK1 HOXA1	3.88e-07	113	82	7	int:TBR1
Interaction	PAX9 interactions	PRR12 MNX1 ZFHX3 BCL7A CIC FOXK1 HOXA1	1.00e-06	130	82	7	int:PAX9
Interaction	PAX6 interactions	PRR12 MNX1 ZNF516 ZFHX3 CHD6 BCL7A SIX3 CIC FOXK1 HOXA1	2.31e-06	366	82	10	int:PAX6
Interaction	TLX3 interactions	PRR12 BRIP1 MNX1 TLE6 ZFHX3 CHD6 TOX2 CIC FOXK1	2.81e-06	291	82	9	int:TLX3
Interaction	ZBTB21 interactions	KLHL29 HDAC5 HDAC4 TESK2 CIC SLX4 MAST3	4.19e-06	161	82	7	int:ZBTB21
Interaction	TLX1 interactions	PRR12 MNX1 ZNF516 ZFHX3 BCL7A CIC FOXK1	7.26e-06	175	82	7	int:TLX1
Interaction	PAX7 interactions	PRR12 MNX1 ZFHX3 CHD6 BCL7A CIC	1.15e-05	124	82	6	int:PAX7
Interaction	GATA2 interactions	PRR12 HDAC5 ZNF516 ZFHX3 CHD6 BCL7A CIC	1.67e-05	199	82	7	int:GATA2
Interaction	FEV interactions	PRR12 MNX1 ZFHX3 CHD6 BCL7A CIC FOXK1	1.90e-05	203	82	7	int:FEV
Interaction	TOP3B interactions	PRR12 NHSL1 GAS2L1 SCAF1 KIAA0930 PHLDB1 AATK HDAC4 INF2 ZNF516 OSBPL5 OBSCN AKNA BCL7A ZBED3 CIC FOXK1 KCNH3	2.01e-05	1470	82	18	int:TOP3B
Interaction	TLX2 interactions	PRR12 MNX1 ZFHX3 CHD6 BCL7A CIC	2.48e-05	142	82	6	int:TLX2
Interaction	DYRK1B interactions	HDAC5 ZNF516 CCDC187 CIC FOXK1	3.49e-05	91	82	5	int:DYRK1B
Interaction	CTBP1 interactions	PRR12 HDAC5 HDAC4 ZNF516 POU5F1 GRIN1 SRRM2 CIC FOXK1	4.00e-05	406	82	9	int:CTBP1
Interaction	BRMS1 interactions	SAP25 HDAC5 HDAC4 CIC FOXK1	4.51e-05	96	82	5	int:BRMS1
Interaction	SOX5 interactions	ZFHX3 POU5F1 CHD6 BCL7A CIC FOXK1	5.20e-05	162	82	6	int:SOX5
Interaction	TEKT5 interactions	CABP2 SPAG8 TOX2 HOXA1	5.50e-05	51	82	4	int:TEKT5
Interaction	CBY1 interactions	KIAA0930 HDAC5 HDAC4 TESK2 MAST3 MAP3K2	9.91e-05	182	82	6	int:CBY1
Interaction	YWHAH interactions	NHSL1 STOX2 KIAA0930 PHLDB1 SETX HDAC5 HDAC4 TESK2 OSBPL5 SRRM2 CIC FOXK1 MAST3 MAP3K2	1.32e-04	1102	82	14	int:YWHAH
Interaction	TLE3 interactions	PRR12 BRIP1 GLI2 ZFHX3 CHD6 SIX3 SRRM2 CIC	1.46e-04	376	82	8	int:TLE3
Interaction	VSX1 interactions	ZNF516 ZFHX3 CHD6 CIC	1.51e-04	66	82	4	int:VSX1
Interaction	FAM110B interactions	STOX2 HDAC4 TESK2 MAST3	1.61e-04	67	82	4	int:FAM110B
Interaction	ZIC5 interactions	POU5F1 CIC	1.62e-04	5	82	2	int:ZIC5
Interaction	GCM1 interactions	PRR12 HDAC5 HDAC4 CIC	1.70e-04	68	82	4	int:GCM1
Interaction	PPP1CC interactions	PRR12 KDM4D AATK INF2 TRIOBP POU5F1 GRIN1 SRRM2 CIC SLX4 MAST3	1.93e-04	738	82	11	int:PPP1CC
Interaction	YWHAB interactions	NHSL1 STOX2 KIAA0930 PHLDB1 HDAC5 HDAC4 ARHGAP23 TESK2 SRRM2 CIC FOXK1 MAST3 MAP3K2	2.17e-04	1014	82	13	int:YWHAB
GeneFamily	Histone deacetylases, class IIA	HDAC5 HDAC4	5.04e-05	4	53	2	992
GeneFamily	Ring finger proteins\|Fanconi anemia complementation groups\|Protein phosphatase 1 regulatory subunits\|BRCA1 A complex\|BRCA1 B complex\|BRCA1 C complex	BRIP1 SLX4	1.55e-03	20	53	2	548
GeneFamily	POU class homeoboxes and pseudogenes	POU5F1 POU2F3	2.05e-03	23	53	2	523
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	PHLDB1 ARHGAP23 OSBPL5 TRIOBP	3.10e-03	206	53	4	682
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Macroglial-oligodendrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIAA0930 PHLDB1 AATK ARHGAP23 NKAIN2 OLIG2 MAST3	1.29e-07	199	87	7	67d8c7e5356f5d409d4f98e8338cf6c499fd7aee
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Macroglial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIAA0930 PHLDB1 AATK ANKS1B NKAIN2 OLIG2 MAST3	1.34e-07	200	87	7	56f1f007ba8c9188a4b10e52744f1e50dc0f155a
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Macroglial-oligodendrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIAA0930 PHLDB1 AATK ARHGAP23 NKAIN2 OLIG2 MAST3	1.34e-07	200	87	7	e5b4821fff40566c4a7dc3f74a14e27eb06b165d
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Macroglial-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIAA0930 PHLDB1 AATK ARHGAP23 NKAIN2 MAST3	2.68e-06	200	87	6	0e85c90719d9ec51a566e230c9dd2909d8df1f52
ToppCell	367C-Myeloid-Macrophage-FABP4+_Macrophage_2\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	KLHL29 BRIP1 INHBA SERPING1 SPAG8	1.30e-05	154	87	5	6c1e7682c43c40b58b371c58deb10b839700ebcc
ToppCell	facs-Marrow-Granulocytes-18m-Lymphocytic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SAP25 ZNF516 TNFRSF10B BCL7A SLC12A5	1.71e-05	163	87	5	7a04192710f55acf5a4681d5f09942358fdb02ff
ToppCell	facs-Aorta-Heart-3m-Mesenchymal-fibrocyte\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLCO5A1 AKNA SEMA4A SSPOP MAST3	1.81e-05	165	87	5	8a52f2dbcbd2bc1662b5e3fac381463fdcc3bf14
ToppCell	tumor_Lymph_Node_/_Brain-Myeloid_cells-Activated_DCs\|Myeloid_cells / Location, Cell class and cell subclass	SLCO5A1 NHSL1 DLGAP4 GCDH CST7	2.67e-05	179	87	5	5f7e6670a0e906a0a5bc75735408361d88e78fa2
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MGAM ASXL3 OBSCN NKAIN2 SSPOP	3.05e-05	184	87	5	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MGAM ASXL3 OBSCN NKAIN2 SSPOP	3.05e-05	184	87	5	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MGAM ASXL3 OBSCN NKAIN2 SSPOP	3.05e-05	184	87	5	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	CF\|World / Disease state, Lineage and Cell class	MGAM AATK TECPR2 CST7 NKAIN2	3.30e-05	187	87	5	eec4d4e4a658e3a61c05745167a1a5e3d39bb43e
ToppCell	(011)_pDC\|World / immune cells in Peripheral Blood (logTPM normalization)	LRRC26 SERPING1 GRIN1 BCL7A PCSK4	3.65e-05	191	87	5	d82ac4f6d9863734e09bf3cb71c1354a49b66b4f
ToppCell	facs-Brain_Non-Myeloid-Striatum\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	INF2 ANKS1B SIX3 NKAIN2 MAST3	3.83e-05	193	87	5	d8ccfb780a75bdf9141f41fb29a076958601ebb4
ToppCell	COVID-19-Heart-Fib_2\|Heart / Disease (COVID-19 only), tissue and cell type	KLHL29 PHLDB1 GLI2 ANKS1B SERPING1	3.93e-05	194	87	5	d91c9f2ec47319051fc398320693fddbe8bbd4d6
ToppCell	LA-02._Fibroblast_II\|World / Chamber and Cluster_Paper	KLHL29 PHLDB1 ANKS1B SERPING1 ZFHX3	4.02e-05	195	87	5	a78b605b49acd8c9d68716266ca269dafcd910b9
ToppCell	facs-Brain_Non-Myeloid-Cortex\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIAA0930 AATK NKAIN2 OLIG2 MAST3	4.12e-05	196	87	5	256fe9bc0815f66a9afe11ba3507ef1372b52fd3
ToppCell	facs-Brain_Non-Myeloid-Striatum-3m-Macroglial-oligodendrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIAA0930 PHLDB1 AATK ARHGAP23 NKAIN2	4.33e-05	198	87	5	a183afe4c2034323f77abfa080f359d67da35e8f
ToppCell	Neuronal-Excitatory\|Neuronal / cells hierarchy compared to all cells using T-Statistic	KIAA0930 ANKS1B NKAIN2 MAST3 KCNH3	4.54e-05	200	87	5	4409065bc7aa995354c71e0f9d6f3726cf393d6b
Drug	Disopyramide [3737-09-5]; Up 200; 11.8uM; MCF7; HT_HG-U133A	INF2 ZFHX3 BCL7A CROCC SRRM2 CIC MAST3 SLC12A5	9.58e-07	199	87	8	7439_UP
Disease	Alcoholic Intoxication, Chronic	PER3 GLI2 TESK2 OSBPL5 GRIN1 NKAIN2	9.74e-05	268	81	6	C0001973
Disease	lateral ventricle volume measurement	SLCO5A1 TRIOBP OLIG2	1.02e-04	33	81	3	EFO_0008487
Disease	PULMONARY HYPERTENSION, PRIMARY, DEXFENFLURAMINE-ASSOCIATED	HDAC5 HDAC4	1.55e-04	7	81	2	C1969342
Disease	Pulmonary Hypertension, Primary, Fenfluramine-Associated	HDAC5 HDAC4	1.55e-04	7	81	2	C1969343
Disease	Pulmonary Hypertension, Primary, 1, With Hereditary Hemorrhagic Telangiectasia	HDAC5 HDAC4	1.55e-04	7	81	2	C3714844
Disease	Pulmonary Hypertension, Primary, 1	HDAC5 HDAC4	1.55e-04	7	81	2	C4552070
Disease	neuroticism measurement, cognitive function measurement	KLHL29 SCAF1 AATK ASXL3 ANKS1B ZFHX3 SNTN MAST3	1.64e-04	566	81	8	EFO_0007660, EFO_0008354
Disease	Arhinencephaly	GLI2 SIX3	2.06e-04	8	81	2	C0078982
Disease	Holoprosencephaly sequence	GLI2 SIX3	3.30e-04	10	81	2	cv:C0079541
Disease	Fanconi anemia	BRIP1 SLX4	6.63e-04	14	81	2	cv:C0015625
Disease	Alobar Holoprosencephaly	GLI2 SIX3	7.64e-04	15	81	2	C0431363
Disease	Lobar Holoprosencephaly	GLI2 SIX3	8.71e-04	16	81	2	C0431362
Disease	Semilobar Holoprosencephaly	GLI2 SIX3	8.71e-04	16	81	2	C0751617
Disease	Idiopathic pulmonary arterial hypertension	HDAC5 HDAC4	8.71e-04	16	81	2	C3203102
Disease	Holoprosencephaly	GLI2 SIX3	9.85e-04	17	81	2	C0079541
Disease	Familial primary pulmonary hypertension	HDAC5 HDAC4	9.85e-04	17	81	2	C0340543
Disease	Bone marrow hypocellularity	BRIP1 SLX4	1.11e-03	18	81	2	C1855710
Disease	nevus count, cutaneous melanoma	KIAA0930 HDAC4 POU2F3	2.03e-03	91	81	3	EFO_0000389, EFO_0004632
Disease	Fanconi Anemia	BRIP1 SLX4	2.14e-03	25	81	2	C0015625
Disease	middle cerebral artery infarction (biomarker_via_orthology)	HDAC5 HDAC4 GRIN1	2.16e-03	93	81	3	DOID:3525 (biomarker_via_orthology)
Disease	Pancytopenia	BRIP1 SLX4	2.32e-03	26	81	2	C0030312
Disease	Acute monocytic leukemia	BRIP1 SLX4	2.32e-03	26	81	2	C0023465
Disease	neurotic disorder	AATK ASXL3 NKAIN2	2.74e-03	101	81	3	EFO_0004257

Protein segments in the cluster

Peptide	Gene	Start	Entry
TPSVGGADSVAPCTP	CCDC187	996	A0A096LP49
STCSSKPGPVEPASS	RTL10	276	Q7L3V2
GASCENPESSFSPVP	CD5L	121	O43866
TSSSSPAEPAQPGAC	DLGAP4	786	Q9Y2H0
PSPGGETQSTSEESC	ASXL3	626	Q9C0F0
SPTPGSEGHSAAPDC	INHBA	21	P08476
APQPCGTTEPTTSSS	RBFA	221	Q8N0V3
SGPECSSSPSPGPES	KCNH3	846	Q9ULD8
PENSPTCSPESSSGG	MON1B	81	Q7L1V2
RNSSTGPTPDCSPPS	ANKS1B	496	Q7Z6G8
STTGGPSPDTCSQDL	CST7	16	O76096
ADCRGPSPVPSQTGS	LDLRAD2	211	Q5SZI1
ACSSAPGSGPSSPNN	HDAC4	291	P56524
SGGTSGSCSPASSEP	MNX1	51	P50219
PTSAQAAGPSSGSCP	CD320	41	Q9NPF0
PDPGTTGTTPVSAEC	MGAM	76	O43451
TSPCGTEEDSSPASP	KIAA0930	266	Q6ICG6
GSSPSQSPCSDLEEP	NHSL1	721	Q5SYE7
EPPDSSSSNTGSGPR	PER3	746	P56645
GGSPRDCTSCPPSST	PCSK4	661	Q6UW60
CSSDAGVSPGPPVQS	OR3A4P	306	P47883
NSGSGSCPSLDSPLD	MAP3K2	211	Q9Y2U5
NGPGCTVTSVTPAPD	NKAIN2	111	Q5VXU1
DPSDPTGSDSSAPGS	PHRF1	831	Q9P1Y6
LAGTTCTASGPEPEP	KDM4D	476	Q6B0I6
SSPGAQSSCSSEPSP	GLI2	656	P10070
QSSCSSEPSPLGSAP	GLI2	661	P10070
SEKSSSSPCVPSPGS	HOXA1	311	P49639
SSCSPGNNSRPSSPG	POU2F3	381	Q9UKI9
TSNPAGDPVGSTRCP	INF2	1016	Q27J81
SGSDVDSDTPPCTTP	TENT4A	596	Q5XG87
NSDGASPEPCTVTPG	POU5F1	106	Q01860
PSTPPSERNGTSSTC	BRIP1	111	Q9BX63
PGPCSSPGSASQASS	OBSCN	7111	Q5VST9
PQLGSPSSDSCPGLS	PLCB3	506	Q01970
SPNPGSPGESSACSP	CEFIP	1056	Q711Q0
SPSTLECSPGSQPPS	CROCC	1476	Q5TZA2
CFGLTEPNSGSDPSS	GCDH	176	Q92947
CSSEGSPGATSPFPV	CHD6	2221	Q8TD26
QALSSSSDEGSPCPG	GAS2L1	596	Q99501
ASTPHCSNPGSSGPD	FRMPD1	966	Q5SYB0
PNSCPASPRGAGSSS	FOXK1	251	P85037
CPEPATTTAAASTGP	AKNA	706	Q7Z591
TDSPTQPTTGSFCPG	SERPING1	111	P05155
SCQSSSSQPERGPSP	MAST3	761	O60307
PEVASSCGPSTSPSN	IP6K1	366	Q92551
SCGPSTSPSNTSPEA	IP6K1	371	Q92551
CNSAPGSGPSSPNSS	HDAC5	311	Q9UQL6
CGSEVTTPENSSSPG	BCL7A	71	Q4VC05
SVSPCEPGTSGFNSS	POLI	596	Q9UNA4
GSCPSPSSSPKEQGD	CABP2	26	Q9NPB3
ESEGTQPPSPSSDTG	NEURL4	1091	Q96JN8
VASDGLPSSEPGPCS	MIER2	416	Q8N344
SAPSCPSSSPSPGEE	SLC12A5	1001	Q9H2X9
PGTSPDASPSSLCGL	OSBPL5	261	Q9H0X9
GLSSSCSDPSPPGES	MINDY2	156	Q8NBR6
SCSGASSSPDPGLDS	RUSC1	166	Q9BVN2
SDPPSPCGSPSSSQG	SAP25	171	Q8TEE9
SCTLHTGTPNSPEPG	RHNO1	181	Q9BSD3
CTTTDHSSNPGPVPG	SPAG8	126	Q99932
GPSPEGSSSTESSPE	SRRM2	1646	Q9UQ35
PSPGDSSCPGDATQE	SSPOP	2806	A2VEC9
QLEGSSPEPSTCPSG	AATK	1061	Q6ZMQ8
EGDPNPSAAPTSTCA	SNTN	16	A6NMZ2
ETNPRPGSCSVGPSS	SEMA4A	371	Q9H3S1
PSPSAPSTSAGLGDC	SLCO5A1	81	Q9H2Y9
PGCPTHGSAESPSTA	SIX3	286	O95343
GEPPAASPEASTCQS	SETX	2606	Q7Z333
GGTVSSSTPSDCPPE	OLIG2	36	Q13516
PGSSSDSESSPGAPS	PRR12	1816	Q9ULL5
CNEDPGSDPTSSPDS	TRIOBP	126	Q9H2D6
PSSCLTPVSPGTSDG	SLX4	1321	Q8IY92
GPDPTSPSSDSGTAQ	CIC	1556	Q96RK0
LESSGAGSSPPAAPC	ZBED3	101	Q96IU2
EGDSASQPSSPGSAC	ZNF516	561	Q92618
APPPSGSTSCGDRDS	SCAF1	666	Q9H7N4
TSPQPGTITPSASGC	STOX2	171	Q9P2F5
VPPGDPGSDSTTCSS	ARHGAP23	1131	Q9P227
STPCSEFPGDSPQSL	TECPR2	486	O15040
ETVTSSPGTPASPCS	TNFRSF10B	196	O14763
SCASHSPSGQEPGPS	PHLDB1	266	Q86UU1
PGSPAAPTTAASCEG	WFIKKN1	81	Q96NZ8
EFPSSSGSCSPGPSN	TOX2	441	Q96NM4
SRPQGTSPCPAGASE	TESK2	526	Q96S53
LGESCNSPGSEPPQS	ZSCAN5C	11	A6NGD5
TSPCPGISNSESSPT	TLE6	16	Q9H808
ETSSLADPCSPSPGA	ZFHX3	2916	Q15911
PATAPAPCTTGSSEA	KLHL29	66	Q96CT2
TASPSGSLGAPDCPE	LRRC26	31	Q2I0M4
CTGPNDTSPGSPRHT	GRIN1	436	Q05586