Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	indanol dehydrogenase activity	AKR1C1 AKR1C2	9.46e-05	4	80	2	GO:0047718
GeneOntologyMolecularFunction	androsterone dehydrogenase (B-specific) activity	AKR1C1 AKR1C2	9.46e-05	4	80	2	GO:0047042
GeneOntologyMolecularFunction	ketoreductase activity	AKR1C1 AKR1C2	9.46e-05	4	80	2	GO:0045703
GeneOntologyMolecularFunction	chlordecone reductase activity	AKR1C1 AKR1C2	9.46e-05	4	80	2	GO:0047743
GeneOntologyMolecularFunction	NADP binding	MTRR NOS2 AKR1C1 AKR1C2	1.12e-04	62	80	4	GO:0050661
GeneOntologyMolecularFunction	NADPH binding	MTRR AKR1C1 AKR1C2	1.51e-04	26	80	3	GO:0070402
GeneOntologyMolecularFunction	trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity	AKR1C1 AKR1C2	1.57e-04	5	80	2	GO:0047115
GeneOntologyMolecularFunction	15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity	AKR1C1 AKR1C2	1.57e-04	5	80	2	GO:0047020
GeneOntologyMolecularFunction	17-beta-ketosteroid reductase (NADPH) activity	AKR1C1 AKR1C2	1.57e-04	5	80	2	GO:0072555
GeneOntologyMolecularFunction	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity	AKR1C1 AKR1C2	1.57e-04	5	80	2	GO:0047006
GeneOntologyMolecularFunction	Delta4-3-oxosteroid 5beta-reductase activity	AKR1C1 AKR1C2	1.57e-04	5	80	2	GO:0047787
GeneOntologyMolecularFunction	lithocholic acid binding	AKR1C1 AKR1C2	1.57e-04	5	80	2	GO:1902121
GeneOntologyMolecularFunction	ketosteroid monooxygenase activity	AKR1C1 AKR1C2	1.57e-04	5	80	2	GO:0047086
GeneOntologyMolecularFunction	geranylgeranyl reductase activity	AKR1C1 AKR1C2	2.35e-04	6	80	2	GO:0045550
GeneOntologyMolecularFunction	17-beta-hydroxysteroid dehydrogenase (NADP+) activity	AKR1C1 AKR1C2	3.29e-04	7	80	2	GO:0072582
GeneOntologyMolecularFunction	5alpha-androstane-3beta,17beta-diol dehydrogenase activity	AKR1C1 AKR1C2	4.37e-04	8	80	2	GO:0047024
GeneOntologyMolecularFunction	androsterone dehydrogenase activity	AKR1C1 AKR1C2	4.37e-04	8	80	2	GO:0047023
GeneOntologyMolecularFunction	enone reductase activity	AKR1C1 AKR1C2	4.37e-04	8	80	2	GO:0035671
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	NOS2 AKR1C1 AKR1C2	5.50e-04	40	80	3	GO:0016709
GeneOntologyMolecularFunction	androstan-3-alpha,17-beta-diol dehydrogenase activity	AKR1C1 AKR1C2	5.60e-04	9	80	2	GO:0047044
GeneOntologyMolecularFunction	NADP+ binding	AKR1C1 AKR1C2	5.60e-04	9	80	2	GO:0070401
GeneOntologyMolecularFunction	testosterone 17-beta-dehydrogenase (NADP+) activity	AKR1C1 AKR1C2	6.99e-04	10	80	2	GO:0047045
GeneOntologyMolecularFunction	bile acid binding	AKR1C1 AKR1C2	6.99e-04	10	80	2	GO:0032052
GeneOntologyMolecularFunction	retinal dehydrogenase activity	AKR1C1 AKR1C2	1.40e-03	14	80	2	GO:0001758
GeneOntologyMolecularFunction	aldose reductase (NADPH) activity	AKR1C1 AKR1C2	1.40e-03	14	80	2	GO:0004032
GeneOntologyMolecularFunction	FMN binding	MTRR NOS2	1.83e-03	16	80	2	GO:0010181
GeneOntologyMolecularFunction	estradiol 17-beta-dehydrogenase [NAD(P)+] activity	AKR1C1 AKR1C2	2.87e-03	20	80	2	GO:0004303
GeneOntologyMolecularFunction	all-trans-retinol dehydrogenase (NAD+) activity	AKR1C1 AKR1C2	4.13e-03	24	80	2	GO:0004745
GeneOntologyBiologicalProcess	response to jasmonic acid	AKR1C1 AKR1C2	8.43e-05	4	78	2	GO:0009753
GeneOntologyBiologicalProcess	progesterone catabolic process	AKR1C1 AKR1C2	8.43e-05	4	78	2	GO:0006709
GeneOntologyBiologicalProcess	cellular response to jasmonic acid stimulus	AKR1C1 AKR1C2	8.43e-05	4	78	2	GO:0071395
GeneOntologyBiologicalProcess	C21-steroid hormone catabolic process	AKR1C1 AKR1C2	8.43e-05	4	78	2	GO:0008208
GeneOntologyBiologicalProcess	farnesol metabolic process	AKR1C1 AKR1C2	1.40e-04	5	78	2	GO:0016487
GeneOntologyBiologicalProcess	farnesol catabolic process	AKR1C1 AKR1C2	1.40e-04	5	78	2	GO:0016488
GeneOntologyBiologicalProcess	negative regulation of isoprenoid metabolic process	AKR1C1 AKR1C2	1.40e-04	5	78	2	GO:0045827
GeneOntologyBiologicalProcess	sesquiterpenoid catabolic process	AKR1C1 AKR1C2	1.40e-04	5	78	2	GO:0016107
GeneOntologyBiologicalProcess	olefinic compound catabolic process	AKR1C1 AKR1C2	1.40e-04	5	78	2	GO:0120256
GeneOntologyBiologicalProcess	negative regulation of retinoic acid biosynthetic process	AKR1C1 AKR1C2	1.40e-04	5	78	2	GO:1900053
GeneOntologyBiologicalProcess	sesquiterpenoid metabolic process	AKR1C1 AKR1C2	2.10e-04	6	78	2	GO:0006714
GeneOntologyBiologicalProcess	polyprenol catabolic process	AKR1C1 AKR1C2	2.10e-04	6	78	2	GO:0016095
GeneOntologyBiologicalProcess	response to prostaglandin D	AKR1C1 AKR1C2	2.93e-04	7	78	2	GO:0071798
GeneOntologyBiologicalProcess	cellular response to prostaglandin D stimulus	AKR1C1 AKR1C2	2.93e-04	7	78	2	GO:0071799
GeneOntologyBiologicalProcess	regulation of retinoic acid biosynthetic process	AKR1C1 AKR1C2	2.93e-04	7	78	2	GO:1900052
GeneOntologyBiologicalProcess	isoprenoid biosynthetic process	PDSS2 AKR1C1 AKR1C2	3.40e-04	36	78	3	GO:0008299
GeneOntologyBiologicalProcess	Rho protein signal transduction	HEG1 SRGAP1 ARHGEF18 GPR55 COL1A2	3.95e-04	164	78	5	GO:0007266
Domain	TRPM_tetra	TRPM6 TRPM7	9.75e-05	4	76	2	IPR032415
Domain	TRPM_tetra	TRPM6 TRPM7	9.75e-05	4	76	2	PF16519
Domain	Alpha_kinase	TRPM6 TRPM7	2.43e-04	6	76	2	PF02816
Domain	FAD_binding_1	MTRR NOS2	2.43e-04	6	76	2	PF00667
Domain	ALPHA_KINASE	TRPM6 TRPM7	2.43e-04	6	76	2	PS51158
Domain	FAD-binding_1	MTRR NOS2	2.43e-04	6	76	2	IPR003097
Domain	Alpha_kinase	TRPM6 TRPM7	2.43e-04	6	76	2	SM00811
Domain	MHCK_EF2_kinase	TRPM6 TRPM7	2.43e-04	6	76	2	IPR004166
Domain	-	MTRR NOS2	2.43e-04	6	76	2	1.20.990.10
Domain	NADPH_Cyt_P450_Rdtase_dom3	MTRR NOS2	2.43e-04	6	76	2	IPR023173
Domain	FLAVODOXIN_LIKE	MTRR NOS2	4.50e-04	8	76	2	PS50902
Domain	Flavodoxin/NO_synth	MTRR NOS2	4.50e-04	8	76	2	IPR008254
Domain	Flavdoxin-like	MTRR NOS2	4.50e-04	8	76	2	IPR001094
Domain	Flavodoxin_1	MTRR NOS2	4.50e-04	8	76	2	PF00258
Domain	zf-C2H2	ZNF729 ZNF559 ZNF451 RBAK ZNF420 ZNF317 ZNF844 ZFX NUFIP1 ZNF114	4.85e-04	693	76	10	PF00096
Domain	KRAB	ZNF729 ZNF559 RBAK ZNF420 ZNF317 ZNF844 ZNF114	6.30e-04	358	76	7	PS50805
Domain	KRAB	ZNF729 ZNF559 RBAK ZNF420 ZNF317 ZNF844 ZNF114	6.30e-04	358	76	7	PF01352
Domain	ALDOKETO_REDUCTASE_1	AKR1C1 AKR1C2	7.20e-04	10	76	2	PS00798
Domain	Aldo/ket_reductase_CS	AKR1C1 AKR1C2	7.20e-04	10	76	2	IPR018170
Domain	Aldo/keto_reductase	AKR1C1 AKR1C2	7.20e-04	10	76	2	IPR020471
Domain	Flavoprotein-like_dom	MTRR NOS2	7.20e-04	10	76	2	IPR029039
Domain	Flavoprot_Pyr_Nucl_cyt_Rdtase	MTRR NOS2	7.20e-04	10	76	2	IPR001709
Domain	ALDOKETO_REDUCTASE_2	AKR1C1 AKR1C2	7.20e-04	10	76	2	PS00062
Domain	ALDOKETO_REDUCTASE_3	AKR1C1 AKR1C2	7.20e-04	10	76	2	PS00063
Domain	-	MTRR NOS2	7.20e-04	10	76	2	3.40.50.360
Domain	KRAB	ZNF729 ZNF559 RBAK ZNF420 ZNF317 ZNF844 ZNF114	7.53e-04	369	76	7	SM00349
Domain	KRAB	ZNF729 ZNF559 RBAK ZNF420 ZNF317 ZNF844 ZNF114	7.65e-04	370	76	7	IPR001909
Domain	OxRdtase_FAD/NAD-bd	MTRR NOS2	1.05e-03	12	76	2	IPR001433
Domain	COS_domain	FSD1L TRIM55	1.05e-03	12	76	2	IPR017903
Domain	COS	FSD1L TRIM55	1.05e-03	12	76	2	PS51262
Domain	NAD_binding_1	MTRR NOS2	1.05e-03	12	76	2	PF00175
Domain	ZINC_FINGER_C2H2_2	ZNF729 ZNF559 ZNF451 RBAK ZNF420 ZNF317 ZNF844 ZFX NUFIP1 ZNF114	1.14e-03	775	76	10	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF729 ZNF559 ZNF451 RBAK ZNF420 ZNF317 ZNF844 ZFX NUFIP1 ZNF114	1.17e-03	777	76	10	PS00028
Domain	Znf_C2H2-like	ZNF729 ZNF559 ZNF451 RBAK ZNF420 ZNF317 ZNF844 ZFX NUFIP1 ZNF114	1.40e-03	796	76	10	IPR015880
Domain	Znf_C2H2	ZNF729 ZNF559 ZNF451 RBAK ZNF420 ZNF317 ZNF844 ZFX NUFIP1 ZNF114	1.52e-03	805	76	10	IPR007087
Domain	SUSHI	HPR C1S C4BPB	1.54e-03	56	76	3	PS50923
Domain	ZnF_C2H2	ZNF729 ZNF559 ZNF451 RBAK ZNF420 ZNF317 ZNF844 ZFX NUFIP1 ZNF114	1.56e-03	808	76	10	SM00355
Domain	Sushi_SCR_CCP_dom	HPR C1S C4BPB	1.62e-03	57	76	3	IPR000436
Domain	-	AKR1C1 AKR1C2	1.89e-03	16	76	2	3.20.20.100
Domain	NADP_OxRdtase_dom	AKR1C1 AKR1C2	2.14e-03	17	76	2	IPR023210
Domain	Aldo_ket_red	AKR1C1 AKR1C2	2.14e-03	17	76	2	PF00248
Domain	Aldo/ket_red/Kv-b	AKR1C1 AKR1C2	2.14e-03	17	76	2	IPR001395
Domain	Fd_Rdtase_FAD-bd	MTRR NOS2	2.67e-03	19	76	2	IPR017927
Domain	FAD_FR	MTRR NOS2	2.67e-03	19	76	2	PS51384
Domain	Riboflavin_synthase-like_b-brl	MTRR NOS2	2.67e-03	19	76	2	IPR017938
Domain	-	ZNF729 ZNF559 RBAK ZNF420 ZNF317 ZNF844 ZFX ZNF114	6.27e-03	679	76	8	3.30.160.60
Domain	Znf_C2H2/integrase_DNA-bd	ZNF729 ZNF559 RBAK ZNF420 ZNF317 ZNF844 ZFX ZNF114	7.12e-03	694	76	8	IPR013087
Pubmed	Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR.	ZNF729 ZNF355P ZNF420 ZNF317 ZNF844	1.06e-07	49	81	5	9630514
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	ZMYND11 KIF23 STUB1 ACAT1 ESD ZNF451 PRIM2 SMC6 USP7 METTL16 NT5DC1 AKR1C1 AKR1C2	6.11e-07	1014	81	13	32416067
Pubmed	The channel kinases TRPM6 and TRPM7 are functionally nonredundant.	TRPM6 TRPM7	5.36e-06	2	81	2	16150690
Pubmed	TRPM6 and TRPM7 differentially contribute to the relief of heteromeric TRPM6/7 channels from inhibition by cytosolic Mg2+ and Mg·ATP.	TRPM6 TRPM7	5.36e-06	2	81	2	28821869
Pubmed	Functional characterization of homo- and heteromeric channel kinases TRPM6 and TRPM7.	TRPM6 TRPM7	5.36e-06	2	81	2	16636202
Pubmed	Relationship of human liver dihydrodiol dehydrogenases to hepatic bile-acid-binding protein and an oxidoreductase of human colon cells.	AKR1C1 AKR1C2	5.36e-06	2	81	2	8573067
Pubmed	Recent developments in intestinal magnesium absorption.	TRPM6 TRPM7	5.36e-06	2	81	2	18301276
Pubmed	Structure of the human 3alpha-hydroxysteroid dehydrogenase type 3 in complex with testosterone and NADP at 1.25-A resolution.	AKR1C1 AKR1C2	5.36e-06	2	81	2	11514561
Pubmed	The alpha-kinases TRPM6 and TRPM7, but not eEF-2 kinase, phosphorylate the assembly domain of myosin IIA, IIB and IIC.	TRPM6 TRPM7	5.36e-06	2	81	2	18675813
Pubmed	Selective loss of AKR1C1 and AKR1C2 in breast cancer and their potential effect on progesterone signaling.	AKR1C1 AKR1C2	5.36e-06	2	81	2	15492289
Pubmed	TRPM6 kinase activity regulates TRPM7 trafficking and inhibits cellular growth under hypomagnesic conditions.	TRPM6 TRPM7	5.36e-06	2	81	2	24858416
Pubmed	CHIP facilitates ubiquitination of inducible nitric oxide synthase and promotes its proteasomal degradation.	STUB1 NOS2	5.36e-06	2	81	2	19362296
Pubmed	Mass Spectrometric Analysis of TRPM6 and TRPM7 Phosphorylation Reveals Regulatory Mechanisms of the Channel-Kinases.	TRPM6 TRPM7	5.36e-06	2	81	2	28220887
Pubmed	Common genetic variants of the ion channel transient receptor potential membrane melastatin 6 and 7 (TRPM6 and TRPM7), magnesium intake, and risk of type 2 diabetes in women.	TRPM6 TRPM7	5.36e-06	2	81	2	19149903
Pubmed	Massive autophosphorylation of the Ser/Thr-rich domain controls protein kinase activity of TRPM6 and TRPM7.	TRPM6 TRPM7	5.36e-06	2	81	2	18365021
Pubmed	Disruption of TRPM6/TRPM7 complex formation by a mutation in the TRPM6 gene causes hypomagnesemia with secondary hypocalcemia.	TRPM6 TRPM7	5.36e-06	2	81	2	14976260
Pubmed	Transient receptor potential melastatin 6 and 7 channels, magnesium transport, and vascular biology: implications in hypertension.	TRPM6 TRPM7	5.36e-06	2	81	2	18192217
Pubmed	cDNA and deduced amino acid sequences of a human colon dihydrodiol dehydrogenase.	AKR1C1 AKR1C2	5.36e-06	2	81	2	8011662
Pubmed	Dysregulation of renal transient receptor potential melastatin 6/7 but not paracellin-1 in aldosterone-induced hypertension and kidney damage in a model of hereditary hypomagnesemia.	TRPM6 TRPM7	5.36e-06	2	81	2	21602712
Pubmed	Magnesium homeostasis in colon carcinoma LoVo cells sensitive or resistant to doxorubicin.	TRPM6 TRPM7	5.36e-06	2	81	2	26563869
Pubmed	Cadmium, cobalt and lead cause stress response, cell cycle deregulation and increased steroid as well as xenobiotic metabolism in primary normal human bronchial epithelial cells which is coordinated by at least nine transcription factors.	AKR1C1 AKR1C2	5.36e-06	2	81	2	18654764
Pubmed	The Different Roles of The Channel-Kinases TRPM6 and TRPM7.	TRPM6 TRPM7	5.36e-06	2	81	2	26179995
Pubmed	Essential role for TRPM6 in epithelial magnesium transport and body magnesium homeostasis.	TRPM6 TRPM7	5.36e-06	2	81	2	16075242
Pubmed	Modeling single nucleotide polymorphisms in the human AKR1C1 and AKR1C2 genes: implications for functional and genotyping analyses.	AKR1C1 AKR1C2	5.36e-06	2	81	2	21217827
Pubmed	Evidence for the expression of TRPM6 and TRPM7 in cardiomyocytes from all four chamber walls of the human heart.	TRPM6 TRPM7	5.36e-06	2	81	2	34326388
Pubmed	Differential mRNA expression and glucocorticoid-mediated regulation of TRPM6 and TRPM7 in the heart and kidney throughout murine pregnancy and development.	TRPM6 TRPM7	5.36e-06	2	81	2	25692682
Pubmed	TRPM6 is Essential for Magnesium Uptake and Epithelial Cell Function in the Colon.	TRPM6 TRPM7	5.36e-06	2	81	2	29912157
Pubmed	Magnesium and its transporters in cancer: a novel paradigm in tumour development.	TRPM6 TRPM7	5.36e-06	2	81	2	22671428
Pubmed	The TRPM6 kinase domain determines the Mg·ATP sensitivity of TRPM7/M6 heteromeric ion channels.	TRPM6 TRPM7	5.36e-06	2	81	2	24385424
Pubmed	The roles of AKR1C1 and AKR1C2 in ethyl-3,4-dihydroxybenzoate induced esophageal squamous cell carcinoma cell death.	AKR1C1 AKR1C2	5.36e-06	2	81	2	26934124
Pubmed	cDNA cloning and expression of the human hepatic bile acid-binding protein. A member of the monomeric reductase gene family.	AKR1C1 AKR1C2	5.36e-06	2	81	2	8486699
Pubmed	Gene variation of the transient receptor potential cation channel, subfamily M, members 6 (TRPM6) and 7 (TRPM7), and type 2 diabetes mellitus: a case-control study.	TRPM6 TRPM7	5.36e-06	2	81	2	20875900
Pubmed	A critical role for CHIP in the aggresome pathway.	STUB1 NOS2	5.36e-06	2	81	2	18955503
Pubmed	Aldo-keto reductase 1C subfamily genes in skin are UV-inducible: possible role in keratinocytes survival.	AKR1C1 AKR1C2	1.60e-05	3	81	2	19320734
Pubmed	Aldo-keto reductases protect metastatic melanoma from ER stress-independent ferroptosis.	AKR1C1 AKR1C2	1.60e-05	3	81	2	31780644
Pubmed	Cyclin-dependent kinase 5, Munc18a and Munc18-interacting protein 1/X11alpha protein up-regulation in Alzheimer's disease.	STXBP1 APBA1	1.60e-05	3	81	2	16413130
Pubmed	Aldo-keto reductases AKR1C1, AKR1C2 and AKR1C3 may enhance progesterone metabolism in ovarian endometriosis.	AKR1C1 AKR1C2	1.60e-05	3	81	2	21232532
Pubmed	Altered expression of 3 alpha-hydroxysteroid dehydrogenases in human glaucomatous optic nerve head astrocytes.	AKR1C1 AKR1C2	1.60e-05	3	81	2	13678667
Pubmed	Interleukin 1β regulates progesterone metabolism in human cervical fibroblasts.	AKR1C1 AKR1C2	1.60e-05	3	81	2	22064385
Pubmed	N-Myc-induced up-regulation of TRPM6/TRPM7 channels promotes neuroblastoma cell proliferation.	TRPM6 TRPM7	1.60e-05	3	81	2	25277194
Pubmed	TRPV6, TRPM6 and TRPM7 Do Not Contribute to Hair-Cell Mechanotransduction.	TRPM6 TRPM7	1.60e-05	3	81	2	29515374
Pubmed	Synergistic effects of Munc18a and X11 proteins on amyloid precursor protein metabolism.	STXBP1 APBA1	1.60e-05	3	81	2	12016213
Pubmed	Phosphorylation of Munc18-1 by Dyrk1A regulates its interaction with Syntaxin 1 and X11α.	STXBP1 APBA1	1.60e-05	3	81	2	22765017
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	PMS1 FRAS1 PKP4 GNAT3 LANCL1 GALNT6 METTL16 DDX55 PLCE1	2.07e-05	650	81	9	38777146
Pubmed	Histone H3 lysine 9 methyltransferases, G9a and GLP are essential for cardiac morphogenesis.	ADAMDEC1 AKR1C1 AKR1C2	3.04e-05	26	81	3	23892084
Pubmed	Studies on a Tyr residue critical for the binding of coenzyme and substrate in mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21): structure of the Y224D mutant enzyme.	AKR1C1 AKR1C2	3.20e-05	4	81	2	20124700
Pubmed	Genetic analysis of Mint/X11 proteins: essential presynaptic functions of a neuronal adaptor protein family.	STXBP1 APBA1	3.20e-05	4	81	2	17167098
Pubmed	Structure and activity of the murine type 5 17beta-hydroxysteroid dehydrogenase gene(1).	AKR1C1 AKR1C2	3.20e-05	4	81	2	10500239
Pubmed	Enzymatic properties of a member (AKR1C20) of the aldo-keto reductase family.	AKR1C1 AKR1C2	3.20e-05	4	81	2	16508162
Pubmed	AKR1C isoforms represent a novel cellular target for jasmonates alongside their mitochondrial-mediated effects.	AKR1C1 AKR1C2	3.20e-05	4	81	2	19487289
Pubmed	Cloning and chromosomal localization of mouse 20alpha-hydroxysteroid dehydrogenase gene.	AKR1C1 AKR1C2	3.20e-05	4	81	2	14967952
Pubmed	Assignment of HSD17B5 encoding type 5 17 beta-hydroxysteroid dehydrogenase to human chromosome bands 10p15-->p14 and mouse chromosome 13 region A2 by in situ hybridization: identification of a new syntenic relationship.	AKR1C1 AKR1C2	3.20e-05	4	81	2	10393440
Pubmed	Localization of 20alpha-hydroxysteroid dehydrogenase mRNA in mouse brain by in situ hybridization.	AKR1C1 AKR1C2	3.20e-05	4	81	2	15193432
Pubmed	Mouse Akr1cl gene product is a prostaglandin D2 11-ketoreductase with strict substrate specificity.	AKR1C1 AKR1C2	3.20e-05	4	81	2	31479646
Pubmed	Characterization and functional analysis of the 5'-flanking region of the mouse 20alpha-hydroxysteroid dehydrogenase gene.	AKR1C1 AKR1C2	3.20e-05	4	81	2	15222881
Pubmed	Isolation and characterization of a cDNA encoding mouse 3alpha-hydroxysteroid dehydrogenase: an androgen-inactivating enzyme selectively expressed in female tissues.	AKR1C1 AKR1C2	3.20e-05	4	81	2	16191478
Pubmed	Characterization of two isoforms of mouse 3(17)alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase family.	AKR1C1 AKR1C2	3.20e-05	4	81	2	15577209
Pubmed	Identification of an interleukin-3-regulated aldoketo reductase gene in myeloid cells which may function in autocrine regulation of myelopoiesis.	AKR1C1 AKR1C2	3.20e-05	4	81	2	10702227
Pubmed	Crystal structures of mouse 17alpha-hydroxysteroid dehydrogenase (apoenzyme and enzyme-NADP(H) binary complex): identification of molecular determinants responsible for the unique 17alpha-reductive activity of this enzyme.	AKR1C1 AKR1C2	3.20e-05	4	81	2	17034817
Pubmed	Several distinct enzymes catalyze 20alpha-hydroxysteroid dehydrogenase activity in mouse liver and kidney.	AKR1C1 AKR1C2	3.20e-05	4	81	2	17629694
Pubmed	RECON-Dependent Inflammation in Hepatocytes Enhances Listeria monocytogenes Cell-to-Cell Spread.	AKR1C1 AKR1C2	3.20e-05	4	81	2	29764944
Pubmed	Cloning and characterization of two novel aldo-keto reductases (AKR1C12 and AKR1C13) from mouse stomach.	AKR1C1 AKR1C2	3.20e-05	4	81	2	10526179
Pubmed	Characterization of rat and mouse NAD+-dependent 3alpha/17beta/20alpha-hydroxysteroid dehydrogenases and identification of substrate specificity determinants by site-directed mutagenesis.	AKR1C1 AKR1C2	3.20e-05	4	81	2	17888864
Pubmed	Proteomic identification of binding partners for the brain metabolite lanthionine ketimine (LK) and documentation of LK effects on microglia and motoneuron cell cultures.	STXBP1 LANCL1	3.20e-05	4	81	2	20181595
Pubmed	Mouse 17alpha-hydroxysteroid dehydrogenase (AKR1C21) binds steroids differently from other aldo-keto reductases: identification and characterization of amino acid residues critical for substrate binding.	AKR1C1 AKR1C2	3.20e-05	4	81	2	17442338
Pubmed	Sensing of Bacterial Cyclic Dinucleotides by the Oxidoreductase RECON Promotes NF-κB Activation and Shapes a Proinflammatory Antibacterial State.	AKR1C1 AKR1C2	3.20e-05	4	81	2	28329705
Pubmed	Characterization of 17alpha-hydroxysteroid dehydrogenase activity (17alpha-HSD) and its involvement in the biosynthesis of epitestosterone.	AKR1C1 AKR1C2	3.20e-05	4	81	2	16018803
Pubmed	Reproductive phenotypes in mice with targeted disruption of the 20alpha-hydroxysteroid dehydrogenase gene.	AKR1C1 AKR1C2	3.20e-05	4	81	2	17272929
Pubmed	Rare functional genetic variants in COL7A1, COL6A5, COL1A2 and COL5A2 frequently occur in Chiari Malformation Type 1.	COL6A5 COL1A2	3.20e-05	4	81	2	33974636
Pubmed	Structure of the G225P/G226P mutant of mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) ternary complex: implications for the binding of inhibitor and substrate.	AKR1C1 AKR1C2	3.20e-05	4	81	2	19237748
Pubmed	Involvement of 20alpha-hydroxysteroid dehydrogenase in the maintenance of pregnancy in mice.	AKR1C1 AKR1C2	3.20e-05	4	81	2	18667791
Pubmed	Mefenamic acid enhances anticancer drug sensitivity via inhibition of aldo-keto reductase 1C enzyme activity.	AKR1C1 AKR1C2	3.20e-05	4	81	2	28259989
Pubmed	Stereospecific reduction of 5β-reduced steroids by human ketosteroid reductases of the AKR (aldo-keto reductase) superfamily: role of AKR1C1-AKR1C4 in the metabolism of testosterone and progesterone via the 5β-reductase pathway.	AKR1C1 AKR1C2	3.20e-05	4	81	2	21521174
Pubmed	Molecular cloning of multiple cDNAs encoding human enzymes structurally related to 3 alpha-hydroxysteroid dehydrogenase.	AKR1C1 AKR1C2	3.20e-05	4	81	2	8274401
Pubmed	Crystallization and preliminary X-ray diffraction analysis of mouse 3(17)alpha-hydroxysteroid dehydrogenase.	AKR1C1 AKR1C2	3.20e-05	4	81	2	16511129
Pubmed	Identification of the oxidative 3alpha-hydroxysteroid dehydrogenase activity of rat Leydig cells as type II retinol dehydrogenase.	AKR1C1 AKR1C2	3.20e-05	4	81	2	10803568
Pubmed	AKR1C1 alleviates LPS‑induced ALI in mice by activating the JAK2/STAT3 signaling pathway.	AKR1C1 AKR1C2	3.20e-05	4	81	2	34590152
Pubmed	Localization of multiple human dihydrodiol dehydrogenase (DDH1 and DDH2) and chlordecone reductase (CHDR) genes in chromosome 10 by the polymerase chain reaction and fluorescence in situ hybridization.	AKR1C1 AKR1C2	3.20e-05	4	81	2	7789999
Pubmed	Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts.	PDSS2 MTRR ARMC2 NT5DC1	3.59e-05	79	81	4	18978678
Pubmed	Molecular cloning and characterization of mouse estradiol 17 beta-dehydrogenase (A-specific), a member of the aldoketoreductase family.	AKR1C1 AKR1C2	5.33e-05	5	81	2	7737980
Pubmed	Retinaldehyde is a substrate for human aldo-keto reductases of the 1C subfamily.	AKR1C1 AKR1C2	5.33e-05	5	81	2	21851338
Pubmed	The ECS(SPSB) E3 ubiquitin ligase is the master regulator of the lifetime of inducible nitric-oxide synthase.	STUB1 NOS2	5.33e-05	5	81	2	21549100
Pubmed	Gp130-mediated signaling is necessary for normal osteoblastic function in vivo and in vitro.	IL6ST COL1A2	5.33e-05	5	81	2	14617570
Pubmed	Preterm birth without progesterone withdrawal in 15-hydroxyprostaglandin dehydrogenase hypomorphic mice.	AKR1C1 AKR1C2	5.33e-05	5	81	2	17872381
Pubmed	Mouse 3alpha-hydroxysteroid dehydrogenase mRNA: a marker of lung maturity.	AKR1C1 AKR1C2	5.33e-05	5	81	2	17064890
Pubmed	Close kinship of human 20alpha-hydroxysteroid dehydrogenase gene with three aldo-keto reductase genes.	AKR1C1 AKR1C2	5.33e-05	5	81	2	10672042
Pubmed	Pregnane X receptor (PXR) deficiency promotes hepatocarcinogenesis via induction of Akr1c18 expression and prostaglandin F2α (PGF2α) levels.	AKR1C1 AKR1C2	5.33e-05	5	81	2	38788959
Pubmed	Expression of progesterone metabolizing enzyme genes (AKR1C1, AKR1C2, AKR1C3, SRD5A1, SRD5A2) is altered in human breast carcinoma.	AKR1C1 AKR1C2	5.33e-05	5	81	2	15212687
Pubmed	Munc18-1 regulates early and late stages of exocytosis via syntaxin-independent protein interactions.	STXBP1 APBA1	5.33e-05	5	81	2	15563604
Pubmed	Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis.	AKR1C1 AKR1C2	5.33e-05	5	81	2	16984997
Pubmed	Mints, Munc18-interacting proteins in synaptic vesicle exocytosis.	STXBP1 APBA1	5.33e-05	5	81	2	9395480
Pubmed	Down-regulation of neurosteroid biosynthesis in corticolimbic circuits mediates social isolation-induced behavior in mice.	AKR1C1 AKR1C2	5.33e-05	5	81	2	18003893
Pubmed	Network organization of the human autophagy system.	TBC1D15 KIF23 WIPI1 MAP1A XIRP2 ESD USP7	7.36e-05	437	81	7	20562859
Pubmed	The Gαq/11-provoked induction of Akr1c18 in murine luteal cells is mediated by phospholipase C.	AKR1C1 AKR1C2	7.99e-05	6	81	2	29107092
Pubmed	Expression analysis of the aldo-keto reductases involved in the novel biosynthetic pathway of tetrahydrobiopterin in human and mouse tissues.	AKR1C1 AKR1C2	7.99e-05	6	81	2	19273550
Pubmed	Quantitative appreciation of steroidogenic gene expression in mouse tissues: new roles for type 2 5alpha-reductase, 20alpha-hydroxysteroid dehydrogenase and estrogen sulfotransferase.	AKR1C1 AKR1C2	7.99e-05	6	81	2	15860270
Pubmed	Regulation of progesterone levels during pregnancy and parturition by signal transducer and activator of transcription 5 and 20alpha-hydroxysteroid dehydrogenase.	AKR1C1 AKR1C2	7.99e-05	6	81	2	15471942
Pubmed	MEF2 and NR2F2 cooperate to regulate Akr1c14 gene expression in mouse MA-10 Leydig cells.	AKR1C1 AKR1C2	7.99e-05	6	81	2	26748576
Pubmed	Adrenal 20alpha-hydroxysteroid dehydrogenase in the mouse catabolizes progesterone and 11-deoxycorticosterone and is restricted to the X-zone.	AKR1C1 AKR1C2	7.99e-05	6	81	2	17122075
Pubmed	Decidual prolactin silences the expression of genes detrimental to pregnancy.	AKR1C1 AKR1C2	7.99e-05	6	81	2	17255200
Cytoband	10p15-p14	AKR1C1 AKR1C2	4.59e-05	6	81	2	10p15-p14
Cytoband	Ensembl 112 genes in cytogenetic band chr7q21	SEMA3D SAMD9L GNAT3 COL1A2	2.88e-04	178	81	4	chr7q21
Cytoband	7q21.11	SEMA3D GNAT3	3.18e-04	15	81	2	7q21.11
Cytoband	Ensembl 112 genes in cytogenetic band chr10p15	ZMYND11 AKR1C1 AKR1C2	5.56e-04	90	81	3	chr10p15
Cytoband	3q22.1	NPHP3 COL6A5	2.53e-03	42	81	2	3q22.1
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF729 ZNF559 ZNF451 RBAK ZNF420 ZNF317 ZNF844 ZFX ZNF114	3.81e-04	718	57	9	28
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	HPR C1S C4BPB	7.70e-04	57	57	3	1179
GeneFamily	Aldo-keto reductases	AKR1C1 AKR1C2	9.99e-04	15	57	2	399
GeneFamily	Transient receptor potential cation channels	TRPM6 TRPM7	3.50e-03	28	57	2	249
Coexpression	GSE21927_SPLEEN_MONOCYTE_VS_GMCSF_GCSF_BONE_MARROW_DN	S100A10 ACAT1 INPP5A ZNF844 NT5DC1 MSTO1	3.30e-05	196	81	6	M7565
Coexpression	GSE14000_UNSTIM_VS_4H_LPS_DC_UP	CPSF4 MAP1A LANCL1 ZNF420 MSTO1 TBC1D24	3.39e-05	197	81	6	M3345
Coexpression	GSE11057_NAIVE_CD4_VS_PBMC_CD4_TCELL_UP	CPSF4 ARHGEF18 ZNF420 METTL16 IL6ST AMIGO1	3.49e-05	198	81	6	M3108
Coexpression	GSE40274_LEF1_VS_FOXP3_AND_LEF1_TRANSDUCED_ACTIVATED_CD4_TCELL_DN	KLHL25 ACAT1 ARHGEF18 GALNT6 ACVR1B NUFIP1	3.59e-05	199	81	6	M9159
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_adventitial_fibro_(9)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	SEMA3D FRAS1 APBA1 CCDC178 AKR1C1 AKR1C2 COL1A2	4.95e-08	186	81	7	8915436d09775f2828a7678af203b1082b36e21c
ToppCell	E16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	S100A10 SEMA3D XIRP2 C1S LOXL3 COL1A2	8.65e-07	177	81	6	30f82b04e48940bfcaf2c22677efe6d57ae3f1a7
ToppCell	ASK454-Mesenchymal\|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq	FRAS1 HEG1 SRGAP1 C1S COL6A5 COL1A2	1.35e-06	191	81	6	e30ae7a12439f8a79820b13f03e822c1223fd0cb
ToppCell	ASK454-Mesenchymal-Fibroblast\|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq	FRAS1 HEG1 SRGAP1 C1S COL6A5 COL1A2	1.35e-06	191	81	6	1726add3f392a061536b7aff72ba84303f4a0b1f
ToppCell	LPS_IL1RA_TNF-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	SEMA3D SRGAP1 C1S COL6A5 IL6ST COL1A2	1.71e-06	199	81	6	30d3e8c0681ec11f86dd38c5f48d21187a1b4f90
ToppCell	LPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	SEMA3D SRGAP1 C1S COL6A5 IL6ST COL1A2	1.76e-06	200	81	6	9b0916d8d07ac2bf1739f7be5296bf77ffee6094
ToppCell	LPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	SEMA3D SRGAP1 C1S COL6A5 IL6ST COL1A2	1.76e-06	200	81	6	b79628fd1386aa9a3b0e9fa81def0bc100c3c073
ToppCell	LPS_anti-TNF-Mesenchymal_fibroblastic\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	SEMA3D SRGAP1 C1S COL6A5 IL6ST COL1A2	1.76e-06	200	81	6	50ca6550998e461ef26dd670351060bd940765a8
ToppCell	LPS_only-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|LPS_only / Treatment groups by lineage, cell group, cell type	SEMA3D SRGAP1 C1S COL6A5 IL6ST COL1A2	1.76e-06	200	81	6	a7ef7022b8efcaedb7319b0b43d8c4e99d788fe2
ToppCell	droplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Mesenchymal-fibroblast\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA3D ARHGEF18 C1S PLCE1 COL1A2	5.36e-06	138	81	5	e2659949944bdf39b23c7275e380a7a937e2726c
ToppCell	droplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA3D ARHGEF18 C1S PLCE1 COL1A2	5.36e-06	138	81	5	d5342383c5e52b92c39d7afe76560501be3ea5cd
ToppCell	E16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	S100A10 SEMA3D XIRP2 C1S COL1A2	1.35e-05	167	81	5	fe3338f99f94c0dac37e3d649dfdce82e4a56022
ToppCell	PND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SEMA3D FRAS1 C1S PLCE1 COL1A2	1.60e-05	173	81	5	30d67738633493d47f06ae452424382f069b6c0a
ToppCell	PND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SEMA3D FRAS1 C1S PLCE1 COL1A2	1.65e-05	174	81	5	a9c6edf5c3fc119c24425f921c5566a8356c30fe
ToppCell	E18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SEMA3D FRAS1 C1S PLCE1 COL1A2	1.84e-05	178	81	5	bcbdd45a2307f8aea14122fa0144b96b1f6eec48
ToppCell	E18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SEMA3D FRAS1 C1S PLCE1 COL1A2	1.84e-05	178	81	5	c413861148129be1ee94f2ceb5999840217eebe5
ToppCell	droplet-Heart-4Chambers-21m-Mesenchymal-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PMS1 MAP1A C1S ARMC2 DNAH1	1.89e-05	179	81	5	b44e2d53b82c3c141bfc6539054b19708200a0d9
ToppCell	PND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SEMA3D FRAS1 C1S PLCE1 COL1A2	1.99e-05	181	81	5	330d4322f4c4373f706273c1f4e218b59051b7fd
ToppCell	PND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SEMA3D FRAS1 C1S PLCE1 COL1A2	1.99e-05	181	81	5	3f4d5d79c1286614514b0e8134079d6128a2a23e
ToppCell	COPD-Epithelial-Mesothelial\|Epithelial / Disease state, Lineage and Cell class	HEG1 HPR SRGAP1 C1S COL1A2	2.39e-05	188	81	5	159d63ecc3653a7449fc6acefd6ef0464845260e
ToppCell	LPS_only-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SEMA3D SRGAP1 C1S COL6A5 COL1A2	2.45e-05	189	81	5	2a22b9fae70afb3dab8476f9c00e48a4df756410
ToppCell	MatrixFB-Fibroblast-C\|MatrixFB / shred on cell class and cell subclass (v4)	S100A10 SEMA3D C1S IL6ST COL1A2	2.52e-05	190	81	5	d0106f7a21292f0b96ce4337ec3efbb1bd78dd0a
ToppCell	ILEUM-non-inflamed-(8)_Activated_fibroblasts\|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	KIF23 STXBP1 MAP1A C1S COL1A2	2.52e-05	190	81	5	39fa110d19c97c7cac99f5fb91b26bc08e2f3b42
ToppCell	facs-Aorta-Heart-3m-Mesenchymal-fibroblast\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 HEG1 C1S LOXL3 COL1A2	2.58e-05	191	81	5	9214655dca96d766737c9f30b624d7fe7050342e
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SEMA3D SRGAP1 C1S COL6A5 COL1A2	2.71e-05	193	81	5	fb28717fadd06c3840636d25409ce80c9254bd34
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic-lymphocyte-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	TBC1D15 ZNF420 ZNF844 MSTO1 CDC7	2.78e-05	194	81	5	8f4b63b0b9a40765205e4ca6bd94a675a83dbe3d
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SEMA3D SRGAP1 C1S COL6A5 COL1A2	2.78e-05	194	81	5	60622bd2f75bfe4c37f721cb12f03dab33f2f58d
ToppCell	RA\|World / Chamber and Cluster_Paper	FRAS1 TRIM55 AKR1C1 AKR1C2 PLCE1	2.78e-05	194	81	5	08f0afbb68a63150fbe107a5337299081c3f69e4
ToppCell	5'-Adult-Appendix-Mesenchymal-fibroblastic-Transitional_Stromal_3_(C3+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	C1S AKR1C1 IL6ST PNLIPRP3 COL1A2	2.85e-05	195	81	5	fc43cd295f2cc3f6e9442232e028944f011c82cc
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(CCL11+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADAMDEC1 C1S COL6A5 IL6ST COL1A2	2.92e-05	196	81	5	2ab9735aa7a7e95dcf6b0bdf0427f7b57f6349ee
ToppCell	COPD-Stromal-Fibroblast\|Stromal / Disease state, Lineage and Cell class	S100A10 C1S AKR1C1 AKR1C2 COL1A2	2.92e-05	196	81	5	4930eeb303d174c28fd91021723e26fdf1af9170
ToppCell	LPS_IL1RA_TNF\|World / Treatment groups by lineage, cell group, cell type	SEMA3D SAMD9L C1S COL6A5 COL1A2	2.99e-05	197	81	5	0a6550dce156fc81f15b1e7830d331ca50d87d06
ToppCell	LPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	SRGAP1 C1S COL6A5 IL6ST COL1A2	2.99e-05	197	81	5	fdb92985f7df0c280b87d3e43c2394e70786a2c7
ToppCell	368C-Fibroblasts-Fibroblast-G\|368C / Donor, Lineage, Cell class and subclass (all cells)	FRAS1 C1S COL6A5 IL6ST COL1A2	2.99e-05	197	81	5	156155c2f0c1a2461e45803da578af18ee221660
ToppCell	368C-Fibroblasts-Fibroblast-G-\|368C / Donor, Lineage, Cell class and subclass (all cells)	FRAS1 C1S COL6A5 IL6ST COL1A2	2.99e-05	197	81	5	d5d9263451f6c10cb3b9c17740183ca334e24851
ToppCell	LPS_IL1RA_TNF-Mesenchymal_fibroblastic-Fibroblasts-Diff_MatrixFB\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	SEMA3D C1S COL6A5 IL6ST COL1A2	3.07e-05	198	81	5	0a4b19c3d5e65ecd24fc2ce80ac5276c813282c7
ToppCell	LPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-Diff_MatrixFB\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	SRGAP1 C1S COL6A5 IL6ST COL1A2	3.14e-05	199	81	5	38ed3bc7daa993d9edcf3e7834597ebb06dd24f8
ToppCell	3'-Child09-12-SmallIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADAMDEC1 C1S COL6A5 IL6ST COL1A2	3.14e-05	199	81	5	a272c54baf8de59c0f259e6498d144a0de8d8924
ToppCell	(02)_MMP9/10+-(2)_GFP_FOXI1\|(02)_MMP9/10+ / shred by cell type by condition	SEMA3D ZMYND11 SMC6 ACVR1B USP16	3.14e-05	199	81	5	18a7f9ced4364f45b184bd529f32ef02c27779d3
ToppCell	LPS_anti-TNF-Epithelial_airway-airway_epithelial\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	HPR GALNT6 AKR1C1 DNAH1 SPINK5	3.14e-05	199	81	5	60919c2af31d39a2d36d7bc432e43dab2a4e05fb
ToppCell	(5)_Fibroblast-G\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	FRAS1 C1S COL6A5 IL6ST COL1A2	3.14e-05	199	81	5	b4a737575be9f8c65771832dd8cd25328d5dae0d
ToppCell	LPS_only-Mesenchymal_fibroblastic\|LPS_only / Treatment groups by lineage, cell group, cell type	SRGAP1 C1S COL6A5 IL6ST COL1A2	3.14e-05	199	81	5	211c3a08f2d484ab7a3368006767289088f0d957
ToppCell	3'-Pediatric_IBD-SmallIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADAMDEC1 C1S COL6A5 IL6ST COL1A2	3.14e-05	199	81	5	6139687a3a5025cb98da4dba0183f95fcae3dc61
ToppCell	LPS_IL1RA_TNF-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	SRGAP1 C1S COL6A5 IL6ST COL1A2	3.14e-05	199	81	5	e1849505b92820a219c5a2c35492bdd55579fb48
ToppCell	Transplant_Alveoli_and_parenchyma-Mesenchymal-Fibroblasts\|Mesenchymal / Tissue, Lineage and Cell class of Lung Cells from 10X	S100A10 MAP1A C1S AKR1C1 COL1A2	3.14e-05	199	81	5	f19c683f38bca3bfee40396f27423441051dec67
ToppCell	LPS_anti-TNF-Epithelial_airway\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	HPR GALNT6 AKR1C1 DNAH1 SPINK5	3.14e-05	199	81	5	6aca164bbbb961f34b1e6f1857f91ade5c059405
ToppCell	LPS_only-Mesenchymal_fibroblastic-Fibroblasts\|LPS_only / Treatment groups by lineage, cell group, cell type	SRGAP1 C1S COL6A5 IL6ST COL1A2	3.14e-05	199	81	5	1a0add79f4e34078b3475eb11c85a4234bda197c
ToppCell	ILEUM-non-inflamed-(8)_Fibroblast-(8)_Fibroblasts\|(8)_Fibroblast / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	ADAMDEC1 C1S COL6A5 IL6ST COL1A2	3.14e-05	199	81	5	56d72da6a5fab9cbb2975fe6f87a631debaba6a8
ToppCell	Parenchymal-10x5prime-Stromal-Fibroblastic-Fibro_alveolar\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	FRAS1 SRGAP1 C1S COL6A5 COL1A2	3.22e-05	200	81	5	8c62f05c6042f24287a73fbdf80ff4a56f7ff403
ToppCell	3'-Child04-06-SmallIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADAMDEC1 C1S COL6A5 IL6ST COL1A2	3.22e-05	200	81	5	c5d818203bef80ff97c2e0158cf61970673dd258
ToppCell	LPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts-Diff_MatrixFB\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	SEMA3D C1S COL6A5 IL6ST COL1A2	3.22e-05	200	81	5	3bdba9612cd7c612b76aa9abecc4a6529aabfc1c
ToppCell	LPS_IL1RA_TNF-Mesenchymal_fibroblastic-Fibroblasts\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	SEMA3D C1S COL6A5 IL6ST COL1A2	3.22e-05	200	81	5	44a68bacdb3d5bf563bd35952176995850933a81
ToppCell	LPS_IL1RA_TNF-Mesenchymal_fibroblastic\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	SEMA3D C1S COL6A5 IL6ST COL1A2	3.22e-05	200	81	5	dc61016c61729f69649cfb21f6264e685ce83dea
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c08-GZMK-FOS_h\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TRPM6 ZNF559 ZNF420 COL1A2	1.88e-04	156	81	4	14e2f693a75f1075f40cc7b16ee430262a5de016
ToppCell	PND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SEMA3D HEG1 APBA1 COL1A2	2.02e-04	159	81	4	7ed659163f45e0c4df4782997c0786900c8186c8
ToppCell	E16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	S100A10 SEMA3D C1S COL1A2	2.33e-04	165	81	4	4e13fccd32029e2879e85f8966e582a46c09e4aa
ToppCell	LPS-antiTNF-Epithelial_airway-Club_cells\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GALNT6 AKR1C1 AKR1C2 SPINK5	2.38e-04	166	81	4	1df4bdf7c773cbfa6c93d7a901f9cd3f3fe07a3d
ToppCell	LPS-antiTNF-Epithelial_airway-Club_cells-Airway\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GALNT6 AKR1C1 AKR1C2 SPINK5	2.38e-04	166	81	4	9628522e7af8f8edca733588a364ab2454ac5ca5
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell_prolif\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SEMA3D HEG1 SAMD9L CDC7	2.38e-04	166	81	4	9d4b44eb56ad38c26aed73444edf389abca6bdf6
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FRAS1 C1S PLCE1 COL1A2	2.44e-04	167	81	4	7abc785e688a384672d7fb5a62d32538fe7e5a51
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FRAS1 C1S PLCE1 COL1A2	2.44e-04	167	81	4	d50311b1f66f143bae4c4cf50e2e9b13c85d6920
ToppCell	facs-Lung-EPCAM-18m-Lymphocytic-plasma_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WIPI1 GNAT3 GPR55 C4BPB	2.55e-04	169	81	4	e348d9877a1bcad4f33dd7b2ce6cb0049583c4d2
ToppCell	367C-Fibroblasts-Fibroblast-A_(Fibroblast_progenitors)\|367C / Donor, Lineage, Cell class and subclass (all cells)	ARHGEF18 C1S AKR1C1 COL1A2	2.55e-04	169	81	4	47fd4adfe54777e69a0fabf8bd34f26223f63275
ToppCell	367C-Fibroblasts-Fibroblast-A_(Fibroblast_progenitors)-\|367C / Donor, Lineage, Cell class and subclass (all cells)	ARHGEF18 C1S AKR1C1 COL1A2	2.55e-04	169	81	4	e09259d62cd3e42f0919f231ed1164db59b0b6c3
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADAMDEC1 C1S IL6ST COL1A2	2.55e-04	169	81	4	c0824a93674e2bff0f09b2d2fab5bab016a2e379
ToppCell	facs-Lung-EPCAM-18m-Lymphocytic-Plasma_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WIPI1 GNAT3 GPR55 C4BPB	2.55e-04	169	81	4	3167ca0c826244280e0e07d1e02656cf5e4e75a5
ToppCell	cellseq2-Epithelial-Epithelial_Glandular-Goblet-Goblet\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	COL6A5 NOS2 AKR1C1 AKR1C2	2.67e-04	171	81	4	25c1979e972c959e1ce4c57804f976f53a247ad7
ToppCell	cellseq2-Epithelial-Epithelial_Glandular-Goblet\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	COL6A5 NOS2 AKR1C1 AKR1C2	2.67e-04	171	81	4	fe27bf581c75ef33c2848878e51ed16b275a4c8e
ToppCell	P07-Mesenchymal-mesenchymal_fibroblast-mesothelial_cell_of_visceral_pleura\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	SEMA3D FRAS1 C1S PLCE1	2.73e-04	172	81	4	9a256db817c1af1802203cc88a55d608fb328c63
ToppCell	PND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SEMA3D FRAS1 C1S PLCE1	2.79e-04	173	81	4	ee7d1429f23f1b89a9a9f7bc07a84a44cf7acd1c
ToppCell	PND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SEMA3D FRAS1 C1S PLCE1	2.79e-04	173	81	4	3725525b99a6011eda2ff5459b4fd2e1eab1f090
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS-Exc_L5-6_THEMIS_GPR21\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	S100A10 FRAS1 AKR1C1 AKR1C2	2.85e-04	174	81	4	0df738309b7b6e77675ea74e7a87e66601b0073d
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Degenerative_Distal_Convoluted_Tubule_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TRPM6 FRAS1 TRPM7 CCDC178	2.91e-04	175	81	4	787ac1a12cda10af5c8830471702a4cbaf43e79e
ToppCell	3'-Adult-Distal_Rectal-Epithelial-Tuft-related-Microfold_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	S100A10 C4BPB AKR1C2 SPINK5	2.91e-04	175	81	4	8a37b2811f39bb9baa537e8755a29d559eb8185a
ToppCell	COVID-19_Mild-Neu_3\|COVID-19_Mild / 5 Neutrophil clusters in COVID-19 patients	S100A10 NPHP3 MAP1A DDX55	2.98e-04	176	81	4	2049767fd591045cfcf5b1071d80798e52843f27
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS-Exc_L5-6_THEMIS_GPR21\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	S100A10 FRAS1 AKR1C1 AKR1C2	2.98e-04	176	81	4	03d194c9814e12802cd932afade69e868814cb78
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	S100A10 FRAS1 AKR1C1 AKR1C2	3.04e-04	177	81	4	64fbf799e7b0c4003b2f486cc41b0f7e7c11ea0c
ToppCell	356C-Fibroblasts-Fibroblast-G\|356C / Donor, Lineage, Cell class and subclass (all cells)	FRAS1 C1S COL6A5 COL1A2	3.04e-04	177	81	4	8220cc2fc0ee8764a67a3be51d75248be2453040
ToppCell	356C-Fibroblasts-Fibroblast-G-\|356C / Donor, Lineage, Cell class and subclass (all cells)	FRAS1 C1S COL6A5 COL1A2	3.04e-04	177	81	4	7617270f49cd6b7ba66db72d20560cee985012b2
ToppCell	3'-Adult-Distal_Rectal-Epithelial-Tuft-related\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	S100A10 C4BPB AKR1C2 SPINK5	3.11e-04	178	81	4	a95bb77a2c2ce7c38989e6f971812f7ee9f5bd4b
ToppCell	PND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_G2M\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KIF23 C1S GALNT6 PLCE1	3.11e-04	178	81	4	c77a1d1a9aef0ab51b4408b9e84f201219788ca2
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	S100A10 FRAS1 AKR1C1 AKR1C2	3.11e-04	178	81	4	a62137d7f5fac16619f8a02844cdb0be7a794bf2
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	S100A10 FRAS1 AKR1C1 AKR1C2	3.17e-04	179	81	4	820289f14ecf165758529c236bb220bb1a744f02
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS-Exc_L5-6_THEMIS_GPR21\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	S100A10 FRAS1 AKR1C1 AKR1C2	3.17e-04	179	81	4	e5f781d35449628a7f356d71e26231dd63482eec
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TRPM6 FRAS1 TRPM7 CCDC178	3.17e-04	179	81	4	666072c0e8448dbaec1683d18368ec2502453f90
ToppCell	5'-Adult-SmallIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADAMDEC1 C1S COL6A5 COL1A2	3.24e-04	180	81	4	f2f6e83127a4a415e65c76a35efa8175fbd5b5d9
ToppCell	P03-Mesenchymal-mesenchymal_fibroblast-mesothelial_cell_of_visceral_pleura\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	FRAS1 C1S GALNT6 PLCE1	3.24e-04	180	81	4	2ccc77d769d3ffd77ab3af45e4f192785b6db79c
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MAP1A C1S COL6A5 COL1A2	3.31e-04	181	81	4	c6d2a13df3b74fade3b0c71e285b4c14c8e52413
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	XIRP2 SRGAP1 APBA1 PLCE1	3.31e-04	181	81	4	5bf7aa43f6e6ecce15c95928b91195544d6928c4
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS-Exc_L5-6_THEMIS_IL7R\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	S100A10 FRAS1 AKR1C1 AKR1C2	3.31e-04	181	81	4	b9fe3833a6a56b9fbe5c257393fdbea5bf8ac4a3
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	FRAS1 SRGAP1 COL6A5 COL1A2	3.31e-04	181	81	4	9ede19228ba5c0668a9c06c915510b95585216ef
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MAP1A C1S COL6A5 COL1A2	3.31e-04	181	81	4	c62b0a2422377ffadaab63edd538e87a06fa5017
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	XIRP2 SRGAP1 APBA1 PLCE1	3.31e-04	181	81	4	8e751f5d7cd2d328ec0196d874e8a507e8c4e1a9
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS-Exc_L5-6_THEMIS_GPR21\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	S100A10 FRAS1 AKR1C1 AKR1C2	3.38e-04	182	81	4	1647367b75b4b107af06bb934394168230cfd7c2
ToppCell	droplet-Marrow-nan-3m-Myeloid-promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	S100A10 ACER3 SMC6 APBA1	3.38e-04	182	81	4	bc8d621be57f76d718d9b0f11e023b0f4dcb668d
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-myocytic-myofibroblast\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SEMA3D ADAMDEC1 C1S COL1A2	3.45e-04	183	81	4	af8d86f15a549064530d94bd47081daf59d58ecd
ToppCell	368C-Lymphocytic-CD4_T-cell-Treg_cell_2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	SEMA3D FSD1L AKR1C1 IL6ST	3.45e-04	183	81	4	fef51dcf180e6d4e136362c7e140ec5ef372e6d0
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TRPM6 FRAS1 TRPM7 CCDC178	3.45e-04	183	81	4	2e831a4d99c6f983793df71c0994124c943c6da9
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 XIRP2 PLCE1 DNAH1	3.52e-04	184	81	4	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 XIRP2 PLCE1 DNAH1	3.52e-04	184	81	4	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
Computational	Neighborhood of EIF4E	PMS1 CPSF4 LANCL1 NUFIP1 CDC7	3.98e-05	85	49	5	MORF_EIF4E
Drug	geldanamycin	SEMA3D ZMYND11 STUB1 INPP5A RBAK METTL16 NOS2 IL6ST ZFX	6.15e-06	371	80	9	ctd:C001277
Drug	(10ALPHA,13ALPHA,14BETA,17ALPHA)-17-HYDROXYANDROST-4-EN-3-ONE	AKR1C1 AKR1C2	1.22e-05	2	80	2	DB07768
Drug	phenylethylamine	KIF23 ACER3 MTRR LOXL3 NOS2	1.55e-05	89	80	5	CID000001001
Drug	drospirenone	NOS2 AKR1C1 AKR1C2	1.84e-05	15	80	3	ctd:C035144
Drug	cyclopentanone	AKR1C1 AKR1C2	3.65e-05	3	80	2	ctd:C007201
Drug	5-dihydrodeoxycorticosterone	AKR1C1 AKR1C2	3.65e-05	3	80	2	ctd:C454687
Drug	4-benzoylbenzoic acid	AKR1C1 AKR1C2	3.65e-05	3	80	2	ctd:C058818
Drug	cyclopentanol	AKR1C1 AKR1C2	3.65e-05	3	80	2	ctd:C016327
Drug	dichloro(4-cymene)ruthenium(II)	AKR1C1 AKR1C2	3.65e-05	3	80	2	ctd:C530610
Drug	oxcarbazepine	NOS2 AKR1C1 AKR1C2	3.89e-05	19	80	3	ctd:C036006
Drug	coniferaldehyde	NOS2 AKR1C1 AKR1C2	5.31e-05	21	80	3	ctd:C075384
Drug	Diphenylpyraline hydrochloride [132-18-3]; Up 200; 12.6uM; PC3; HT_HG-U133A	PKP4 USP7 ACVR1B IL6ST SPINK5 COL1A2	6.86e-05	197	80	6	4299_UP
Drug	tetrahydrodeoxycorticosterone	AKR1C1 AKR1C2	7.28e-05	4	80	2	ctd:C009413
Drug	Pregnanes	AKR1C1 AKR1C2	7.28e-05	4	80	2	ctd:D011278
Drug	tetralol	AKR1C1 AKR1C2	7.28e-05	4	80	2	ctd:C019106
Drug	gliquidone	AKR1C1 AKR1C2	7.28e-05	4	80	2	ctd:C010969
Drug	3',3'',5',5''-tetrabromophenolphthalein	AKR1C1 AKR1C2	7.28e-05	4	80	2	ctd:C018156
Drug	cloxazolam	AKR1C1 AKR1C2	7.28e-05	4	80	2	ctd:C005522
Disease	Neoplasms, Hormone-Dependent	AKR1C1 AKR1C2	2.07e-05	3	78	2	C0027661
Disease	Ambiguous Genitalia	AKR1C1 AKR1C2	6.86e-05	5	78	2	C0266362
Disease	Pseudohermaphroditism	AKR1C1 AKR1C2	6.86e-05	5	78	2	C0033804
Disease	Hermaphroditism	AKR1C1 AKR1C2	6.86e-05	5	78	2	C0019269
Disease	Intersex Conditions	AKR1C1 AKR1C2	6.86e-05	5	78	2	C2930618
Disease	Sex Differentiation Disorders	AKR1C1 AKR1C2	6.86e-05	5	78	2	C2930619
Disease	Degenerative polyarthritis	ESD AKR1C1 AKR1C2 COL1A2	1.10e-04	93	78	4	C0029408
Disease	Osteoarthrosis Deformans	ESD AKR1C1 AKR1C2 COL1A2	1.10e-04	93	78	4	C0086743
Disease	Disorders of Sex Development	AKR1C1 AKR1C2	1.44e-04	7	78	2	C0036875
Disease	Epilepsy, Myoclonic, Infantile	STXBP1 TBC1D24	3.06e-04	10	78	2	C0917800
Disease	diabetic maculopathy	DLEU1 USP7	4.48e-04	12	78	2	EFO_0010133
Disease	response to methotrexate	AKR1C1 AKR1C2	8.08e-04	16	78	2	GO_0031427
Disease	inferior parietal cortex volume measurement	TBC1D15 NT5DC1	1.15e-03	19	78	2	EFO_0010307
Disease	hypothyroidism (biomarker_via_orthology)	MAP1A NOS2 COL1A2	1.26e-03	80	78	3	DOID:1459 (biomarker_via_orthology)
Disease	Renal glomerular disease	NPHP3 PLCE1	1.68e-03	23	78	2	C0268731
Disease	Glomerulopathy Assessment	NPHP3 PLCE1	1.68e-03	23	78	2	C4521256
Disease	low density lipoprotein cholesterol measurement, alcohol consumption measurement	HPR SMC6 NT5DC1	2.32e-03	99	78	3	EFO_0004611, EFO_0007878
Disease	obesity (is_marker_for)	NOS2 AKR1C1 AKR1C2	2.46e-03	101	78	3	DOID:9970 (is_marker_for)
Disease	low density lipoprotein cholesterol measurement, alcohol drinking	HPR SMC6 NT5DC1	2.53e-03	102	78	3	EFO_0004329, EFO_0004611

Protein segments in the cluster

Peptide	Gene	Start	Entry
YLQHLCFGDNKVKME	PKP4	551	Q99569
HDSVELNCKMKFAVY	ESD	21	P10768
CMFECFKIKNSVNYH	ACER3	106	Q9NUN7
DFQEDLYCMNSKKLH	AMIGO1	246	Q86WK6
MKEKYGVFCSGHNEA	ARHGEF18	546	Q6ZSZ5
NMKHFDSFKCADIYA	ACVR1B	391	P36896
MEQYKGDKDVCTNIA	ARMC2	481	Q8NEN0
KHDAEVQNMAFQYGK	PDSS2	271	Q86YH6
TKFHQYAMNGEKDIN	NOS2	11	P35228
FTNNAMKCNCKYDGH	LOXL3	706	P58215
AYKKEMASFFDCNHA	PNLIPRP3	266	Q17RR3
IQHNYKMSAFKENCG	NT5DC1	166	Q5TFE4
DKVKNCTVYIHDDSM	FRAS1	2981	Q86XX4
IHKNGYSEQECMEFK	GNAT3	56	A8MTJ3
EEDATKAEGFYQKHM	MAP1A	671	P78559
YHKMNNEKQAEDCIT	LANCL1	121	O43813
SMCQAYFQAENEEKK	SPINK5	331	Q9NQ38
MDSQKYCFKENENVT	FSD1L	1	Q9BXM9
LNEHTFCVGMSKYQE	HPR	276	P00739
HIYVCGDAKNMAKDV	MTRR	646	Q9UBK8
SHNADKYQMGDCCKE	DLEU1	56	O43261
YMVCKADEKFNQLVH	DDX55	246	Q8NHQ9
AQTVFDHYMQEKKDC	CCDC178	706	Q5BJE1
YDEFLVHMKQGQKDA	GPATCH1	516	Q9BRR8
LHCQEFGGKNYEASM	INPP5A	51	Q14642
SICMIQKYNHDGEAG	MSTO1	176	Q9BUK6
ATEVDDMCFNYAKKN	METTL16	131	Q86W50
AQHDQLMQKCFGDEY	KRI1	391	Q8N9T8
QCKSGYFQFNKMDHS	HEG1	1201	Q9ULI3
GKVEKYMCFHNMSDD	GPR55	161	Q9Y2T6
KGTHYQVACQKYFEM	PRIM2	416	P49643
GEDFLNSCHKVMEFK	DNAH1	3801	Q9P2D7
HCKNSIAYMDEETGN	COL1A2	1271	P08123
CHMFSDQYLDKEENS	IFT52	216	Q9Y366
KEKCMDYFHVNANYI	IL6ST	51	P40189
GGQTFMCDKIYQVDH	KLHL25	301	Q9H0H3
NVMGVKYCFRKNDHV	CDC7	116	O00311
QQACIEAKHDKYMAD	STUB1	196	Q9UNE7
QEKEEGYKKHCFNAF	GALNT6	131	Q8NCL4
KYKEGAVDADMQVHF	COL6A5	211	A8TX70
EYFLHDDMKNCGVNC	C1S	161	P09871
DKITFMCNDHYILKG	C4BPB	101	P20851
GKRQYKMICHVFESE	APBA1	581	Q02410
CKKGDQCEFLHEYDM	CPSF4	76	O95639
IYRMKHQFGNEIKEC	PMS1	901	P54277
KNHNMYVAGCTEVEV	KIF23	256	Q02241
KFEFQSHMGDEVCQV	SRGAP1	331	Q7Z6B7
LKQYEKNCEGEDNMS	NPHP3	926	Q7Z494
DNSACNKGKVYDMEL	PLCE1	1631	Q9P212
IEKQHKNCENFYSFM	SAMD9L	876	Q8IVG5
DVYNKIHMGSCAENT	ACAT1	186	P24752
AEDCMKHYQGTVDKL	STXBP1	351	P61764
IACNDYFVVHMKQKG	S100A10	81	P60903
QKKDSGMYYCKAQEH	SEMA3D	656	O95025
FMVDNKAIYDICHCN	TUBA4B	141	Q9H853
MEHCYYKGNILNEKN	ADAMDEC1	121	O15204
MDSKYQCVKLNDGHF	AKR1C1	1	Q04828
MDSKYQCVKLNDGHF	AKR1C2	1	P52895
YNCFVDKDKMDAAIQ	TBC1D24	6	Q9ULP9
EKHSGDFMQQYSQKE	XIRP2	2211	A4UGR9
VEKHVFSANTMGYKC	ZNF451	486	Q9Y4E5
CEDMFDSQEYVKQHC	ZNF451	611	Q9Y4E5
ASKAFQMEKIEHGYE	TRIM55	291	Q9BYV6
KYFHEKMEDVNCSCE	TRPM6	1156	Q9BX84
EGVMHKEYCVNQKDL	USP16	501	Q9Y5T5
RGFKNQEKYDKHMSE	NUFIP1	181	Q9UHK0
NECGKTYHGEKMCEF	RBAK	166	Q9NYW8
TYHGEKMCEFNQNGD	RBAK	171	Q9NYW8
FYHEEFTEKCKQMCV	TTC41P	271	Q6P2S7
QRAYCGKMNFDHKNE	SMC6	951	Q96SB8
ESEKQQIMEKHYGFN	TBC1D15	571	Q8TC07
FQMQEKAHTGEKLYD	ZNF844	156	Q08AG5
MCHDKYTKIFNDFKD	ZMYND11	466	Q15326
NKMHKCKFCEYETAE	ZFX	516	P17010
YECKECGKMFSHGSQ	ZNF420	391	Q8TAQ5
NEHMRAHTGEKFYKC	ZNF355P	116	Q9NSJ1
RQMNVYHFKKGTEIC	WIPI1	81	Q5MNZ9
HMQTQDGEKFYECKA	ZNF559	231	Q9BR84
CGHQGNDMYDEEKVK	USP7	576	Q93009
YDGRKMHECHQCQKA	ZNF317	216	Q96PQ6
QCVEMYFNEKDDKFH	TRPM7	1176	Q96QT4
CKSANEGKMHKEGYN	ZNF729	126	A6NN14
EGKMHKEGYNKLNQC	ZNF729	131	A6NN14
THGREKMYDFTQCEN	ZNF114	241	Q8NC26