Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	RFX1_trans_act	RFX1 RFX2 RFX3	9.43e-08	3	86	3	IPR007668
Domain	RFX1_trans_act	RFX1 RFX2 RFX3	9.43e-08	3	86	3	PF04589
Domain	RFX_DNA_binding	RFX1 RFX2 RFX3	7.76e-06	9	86	3	PF02257
Domain	DNA-bd_RFX	RFX1 RFX2 RFX3	7.76e-06	9	86	3	IPR003150
Domain	RFX_DBD	RFX1 RFX2 RFX3	7.76e-06	9	86	3	PS51526
Domain	-	RASA4 RASA4B	6.27e-05	3	86	2	4.10.1130.10
Domain	Adcy_conserved_dom	ADCY4 ADCY6	3.11e-04	6	86	2	IPR009398
Domain	DUF1053	ADCY4 ADCY6	3.11e-04	6	86	2	PF06327
Domain	LRRCT	TRIL LRIG3 TLR5	4.25e-04	32	86	3	PF01463
Domain	AC_N	ADCY4 ADCY6	5.76e-04	8	86	2	IPR032628
Domain	Adcy	ADCY4 ADCY6	5.76e-04	8	86	2	IPR030672
Domain	AC_N	ADCY4 ADCY6	5.76e-04	8	86	2	PF16214
Domain	BTK	RASA4 RASA4B	7.39e-04	9	86	2	SM00107
Domain	Znf_Btk_motif	RASA4 RASA4B	7.39e-04	9	86	2	IPR001562
Domain	BTK	RASA4 RASA4B	7.39e-04	9	86	2	PF00779
Domain	ZF_BTK	RASA4 RASA4B	7.39e-04	9	86	2	PS51113
Domain	Cys-rich_flank_reg_C	TRIL LRIG3 TLR5 LINGO4	7.92e-04	90	86	4	IPR000483
Domain	LRRCT	TRIL LRIG3 TLR5 LINGO4	7.92e-04	90	86	4	SM00082
Domain	RasGAP	RASA4 RASA4B	1.84e-03	14	86	2	SM00323
Domain	RasGAP_CS	RASA4 RASA4B	1.84e-03	14	86	2	IPR023152
Domain	RasGAP	RASA4 RASA4B	2.12e-03	15	86	2	PF00616
Domain	RAS_GTPASE_ACTIV_1	RASA4 RASA4B	2.12e-03	15	86	2	PS00509
Domain	RAS_GTPASE_ACTIV_2	RASA4 RASA4B	2.12e-03	15	86	2	PS50018
Domain	-	RASA4 RASA4B	2.41e-03	16	86	2	1.10.506.10
Domain	A/G_cyclase_CS	ADCY4 ADCY6	2.72e-03	17	86	2	IPR018297
Domain	RUN	RUSC1 RUNDC1	3.06e-03	18	86	2	SM00593
Domain	RasGAP_dom	RASA4 RASA4B	3.06e-03	18	86	2	IPR001936
Domain	Nucleotide_cyclase	ADCY4 ADCY6	3.06e-03	18	86	2	IPR029787
Domain	-	ADCY4 ADCY6	3.06e-03	18	86	2	3.30.70.1230
Domain	DH_1	ARHGEF10 ARHGEF7 ARHGEF10L	3.07e-03	63	86	3	PS00741
Domain	RUN	RUSC1 RUNDC1	3.41e-03	19	86	2	PS50826
Domain	GUANYLATE_CYCLASE_1	ADCY4 ADCY6	3.41e-03	19	86	2	PS00452
Domain	Guanylate_cyc	ADCY4 ADCY6	3.41e-03	19	86	2	PF00211
Domain	RUN	RUSC1 RUNDC1	3.41e-03	19	86	2	PF02759
Domain	GUANYLATE_CYCLASE_2	ADCY4 ADCY6	3.41e-03	19	86	2	PS50125
Domain	Run_dom	RUSC1 RUNDC1	3.41e-03	19	86	2	IPR004012
Domain	A/G_cyclase	ADCY4 ADCY6	3.41e-03	19	86	2	IPR001054
Domain	CYCc	ADCY4 ADCY6	3.41e-03	19	86	2	SM00044
Domain	RhoGEF	ARHGEF10 ARHGEF7 ARHGEF10L	3.81e-03	68	86	3	SM00325
Domain	RhoGEF	ARHGEF10 ARHGEF7 ARHGEF10L	4.13e-03	70	86	3	PF00621
Domain	DH_2	ARHGEF10 ARHGEF7 ARHGEF10L	4.13e-03	70	86	3	PS50010
Domain	DH-domain	ARHGEF10 ARHGEF7 ARHGEF10L	4.30e-03	71	86	3	IPR000219
Domain	-	ARHGEF10 ARHGEF7 ARHGEF10L	4.30e-03	71	86	3	1.20.900.10
Domain	TAS2R	TAS2R3 TAS2R38	6.34e-03	26	86	2	PF05296
Domain	T2R	TAS2R3 TAS2R38	6.34e-03	26	86	2	IPR007960
Domain	Rho_GTPase_activation_prot	RASA4 ARHGAP26 RASA4B	7.81e-03	88	86	3	IPR008936
Domain	LRR_8	TRIL LRIG3 TLR5 LINGO4	8.05e-03	171	86	4	PF13855
Domain	Leu-rich_rpt_typical-subtyp	TRIL LRIG3 TLR5 LINGO4	9.06e-03	177	86	4	IPR003591
Domain	LRR_TYP	TRIL LRIG3 TLR5 LINGO4	9.06e-03	177	86	4	SM00369
Pathway	KEGG_TASTE_TRANSDUCTION	TAS2R3 ADCY4 TAS2R38 ADCY6	7.35e-05	52	61	4	M5785
Pathway	REACTOME_SIGNALING_BY_GPCR	TAS2R3 ADCY4 RGS20 ARHGEF10 AVPR1B ARHGEF7 TAS2R38 PTGER2 PIK3R5 ADCY6 ARHGEF10L	8.87e-05	646	61	11	MM14962
Pathway	REACTOME_SIGNALING_BY_GPCR	TAS2R3 ADCY4 RGS20 ARHGEF10 AVPR1B ARHGEF7 TAS2R38 PTGER2 PIK3R5 ADCY6 ARHGEF10L	1.85e-04	702	61	11	M746
Pubmed	Involvement of RFX proteins in transcriptional activation from a Ras-responsive enhancer element.	RFX1 RFX2 RFX3	1.62e-08	3	89	3	15024578
Pubmed	Dimeric RFX proteins contribute to the activity and lineage specificity of the interleukin-5 receptor alpha promoter through activation and repression domains.	RFX1 RFX2 RFX3	1.62e-08	3	89	3	10330134
Pubmed	Ciliogenic RFX transcription factors regulate FGF1 gene promoter.	RFX1 RFX2 RFX3	1.62e-08	3	89	3	22415835
Pubmed	Drosophila regulatory factor X is necessary for ciliated sensory neuron differentiation.	RFX1 RFX2 RFX3	1.62e-08	3	89	3	12403718
Pubmed	RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins.	RFX1 RFX2 RFX3	1.62e-08	3	89	3	8289803
Pubmed	Interplay of RFX transcription factors 1, 2 and 3 in motile ciliogenesis.	RFX1 RFX2 RFX3	1.62e-08	3	89	3	32725242
Pubmed	Human regulatory factor X 4 (RFX4) is a testis-specific dimeric DNA-binding protein that cooperates with other human RFX members.	RFX1 RFX2 RFX3	6.47e-08	4	89	3	11682486
Pubmed	Differential expression of Rfx1-4 during mouse spermatogenesis.	RFX1 RFX2 RFX3	6.47e-08	4	89	3	19596083
Pubmed	CAPRI regulates Ca(2+)-dependent inactivation of the Ras-MAPK pathway.	RASA4 RASA4B	6.48e-06	2	89	2	11448776
Pubmed	The genes for MHC class II regulatory factors RFX1 and RFX2 are located on the short arm of chromosome 19.	RFX1 RFX2	6.48e-06	2	89	2	1505960
Pubmed	RFX1 and RFX3 Transcription Factors Interact with the D Sequence of Adeno-Associated Virus Inverted Terminal Repeat and Regulate AAV Transduction.	RFX1 RFX3	6.48e-06	2	89	2	29317724
Pubmed	An essential function for the calcium-promoted Ras inactivator in Fcgamma receptor-mediated phagocytosis.	RASA4 RASA4B	6.48e-06	2	89	2	16041389
Pubmed	Differential bitterness in capsaicin, piperine, and ethanol associates with polymorphisms in multiple bitter taste receptor genes.	TAS2R3 TAS2R38	6.48e-06	2	89	2	26785164
Pubmed	Dynamic and coordinated expression profile of dbl-family guanine nucleotide exchange factors in the developing mouse brain.	ARHGEF10 ARHGEF7 ARHGEF10L	1.29e-05	18	89	3	12799088
Pubmed	Role for RFX transcription factors in non-neuronal cell-specific inactivation of the microtubule-associated protein MAP1A promoter.	RFX1 RFX3	1.94e-05	3	89	2	12411430
Pubmed	RFX transcription factors are essential for hearing in mice.	RFX1 RFX3	1.94e-05	3	89	2	26469318
Pubmed	CD28 inhibits T cell adhesion by recruiting CAPRI to the plasma membrane.	RASA4 RASA4B	1.94e-05	3	89	2	25637021
Pubmed	Rfx6 directs islet formation and insulin production in mice and humans.	RFX1 RFX2 RFX3	2.08e-05	21	89	3	20148032
Pubmed	The Rfx4 transcription factor modulates Shh signaling by regional control of ciliogenesis.	RFX1 RFX2 RFX3	2.41e-05	22	89	3	19887680
Pubmed	Ca2+-dependent monomer and dimer formation switches CAPRI Protein between Ras GTPase-activating protein (GAP) and RapGAP activities.	RASA4 RASA4B	3.87e-05	4	89	2	21460216
Pubmed	The RFX family interacts at the collagen (COL1A2) start site and represses transcription.	RFX1 RFX2	3.87e-05	4	89	2	11986307
Pubmed	Transcriptional regulation of the Alström syndrome gene ALMS1 by members of the RFX family and Sp1.	RFX1 RFX2	3.87e-05	4	89	2	20381594
Pubmed	Role of protein kinase C-dependent A-kinase anchoring proteins in lysophosphatidic acid-induced cAMP signaling in human diploid fibroblasts.	ADCY4 ADCY6	3.87e-05	4	89	2	17081159
Pubmed	RFX1 regulates CD70 and CD11a expression in lupus T cells by recruiting the histone methyltransferase SUV39H1.	CD70 RFX1	3.87e-05	4	89	2	21192791
Pubmed	The Shank family of postsynaptic density proteins interacts with and promotes synaptic accumulation of the beta PIX guanine nucleotide exchange factor for Rac1 and Cdc42.	ARHGEF7 SHANK3	3.87e-05	4	89	2	12626503
Pubmed	Identification of an alternatively spliced variant of Ca2+-promoted Ras inactivator as a possible regulator of RANKL shedding.	RASA4 RASA4B	3.87e-05	4	89	2	16234249
Pubmed	Functional reconstitution of G-protein-coupled receptor-mediated adenylyl cyclase activation by a baculoviral co-display system.	PTGER2 ADCY6	3.87e-05	4	89	2	18403039
Pubmed	Human bronchial smooth muscle cells express adenylyl cyclase isoforms 2, 4, and 6 in distinct membrane microdomains.	ADCY4 ADCY6	6.44e-05	5	89	2	21228062
Pubmed	Mammalian adenylyl cyclase family members are randomly located on different chromosomes.	ADCY4 ADCY6	6.44e-05	5	89	2	7959689
Pubmed	RFX proteins, a novel family of DNA binding proteins conserved in the eukaryotic kingdom.	RFX1 RFX3	6.44e-05	5	89	2	8600444
Pubmed	Evolutionarily dynamic alternative splicing of GPR56 regulates regional cerebral cortical patterning.	RFX1 RFX3	6.44e-05	5	89	2	24531968
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	LRIG3 USP38 ARHGEF7 AP5Z1 ARHGAP26 HIP1R ZBTB5 ARHGEF10L	6.52e-05	529	89	8	14621295
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	TRIL LRIG3 BEND3 FAM91A1 SPATA2 CSMD3 ADCY6	8.62e-05	407	89	7	12693553
Pubmed	Dynamic changes in cis-regulatory occupancy by Six1 and its cooperative interactions with distinct cofactors drive lineage-specific gene expression programs during progressive differentiation of the auditory sensory epithelium.	RFX1 RFX2	9.65e-05	6	89	2	31956913
Pubmed	Mapping of adenylyl cyclase genes type I, II, III, IV, V, and VI in mouse.	ADCY4 ADCY6	9.65e-05	6	89	2	7766992
Pubmed	Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland.	ADCY4 ADCY6	9.65e-05	6	89	2	11549699
Pubmed	CYLD Regulates Centriolar Satellites Proteostasis by Counteracting the E3 Ligase MIB1.	CEP350 RUSC1 HUWE1 SPATA2 ANAPC7	1.08e-04	182	89	5	31067453
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PCNX3 SPHK1 ARHGAP26 TMEM132A HIP1R ABCD1 HUWE1 ZDHHC8 WDR59 PRRT4 ARHGEF10L	1.20e-04	1105	89	11	35748872
Pubmed	RFX2 is essential in the ciliated organ of asymmetry and an RFX2 transgene identifies a population of ciliated cells sufficient for fluid flow.	RFX2 RFX3	1.35e-04	7	89	2	22233545
Pubmed	Differential expression of adenylyl cyclase mRNAs in lacrimal glands of NZB/NZW and NOD pre-autoimmune mice.	ADCY4 ADCY6	1.35e-04	7	89	2	12613887
Pubmed	Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	TMEM132A BEND3 HUWE1 ARHGEF10L	1.35e-04	101	89	4	10997877
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	CEP350 LRIG3 SLC4A7 DDX50 BEND3 FAM91A1 RHBDD3 HUWE1 SPATA2	1.71e-04	777	89	9	35844135
Pubmed	Comparative genome mapping in the sequence-based era: early experience with human chromosome 7.	RASA4 RASA4B	1.79e-04	8	89	2	10810084
Pubmed	Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways.	FANCE XRCC3	1.79e-04	8	89	2	15115758
Pubmed	Migratory and adhesive cues controlling innate-like lymphocyte surveillance of the pathogen-exposed surface of the lymph node.	SPHK1 SIGLEC1	2.30e-04	9	89	2	27487469
Pubmed	Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS.	ADCY4 ADCY6	2.30e-04	9	89	2	9417641
Pubmed	Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms.	ADCY4 ADCY6	2.30e-04	9	89	2	12503609
Pubmed	Role of the calcium modulated cyclases in the development of the retinal projections.	ADCY4 ADCY6	2.30e-04	9	89	2	17229090
Pubmed	Locations of human and mouse genes encoding the RFX1 and RFX2 transcription factor proteins.	RFX1 RFX2	2.30e-04	9	89	2	8661125
Pubmed	High-throughput analyses of hnRNP H1 dissects its multi-functional aspect.	ASPHD1 ARHGEF10 ZBTB5 CD70 C1orf159 TMEM214 XRCC3 ANAPC7 ADCY6 ARHGEF10L	2.84e-04	1021	89	10	26760575
Pubmed	Purification and characterization of a soluble form of mammalian adenylyl cyclase.	ADCY4 ADCY6	2.88e-04	10	89	2	8663304
Pubmed	Comprehensive analysis of the expression patterns of the adenylate cyclase gene family in the developing and adult mouse brain.	ADCY4 ADCY6	2.88e-04	10	89	2	16615126
Pubmed	Replication study of candidate genes for cognitive abilities: the Lothian Birth Cohort 1936.	DISC1 SHANK3	2.88e-04	10	89	2	19077115
Pubmed	Mechanism of human immunodeficiency virus-induced complement expression in astrocytes and neurons.	ADCY4 ADCY6	2.88e-04	10	89	2	11884542
Pubmed	G-protein pathway suppressor 2 (GPS2) interacts with the regulatory factor X4 variant 3 (RFX4_v3) and functions as a transcriptional co-activator.	RFX2 RFX3	3.51e-04	11	89	2	18218630
Pubmed	Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures.	ADCY4 ADCY6	3.51e-04	11	89	2	11299302
Pubmed	Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1.	ADCY4 ADCY6	3.51e-04	11	89	2	10089566
Pubmed	gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression.	ADCY4 ADCY6	3.51e-04	11	89	2	10808179
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	SLC4A7 AP5Z1 BEND3 FOXO4 HUWE1 RFX1 RFX2 RFX3 ANAPC7	3.52e-04	857	89	9	25609649
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	LRIG3 FPGS CD70 C1orf159 RHBDD3 TMEM214 HUWE1 ADCY6 TBL2 PIGO	3.85e-04	1061	89	10	33845483
Pubmed	Expression of adenylyl cyclase mRNAs in the denervated and in the developing mouse skeletal muscle.	ADCY4 ADCY6	4.20e-04	12	89	2	9611134
Pubmed	HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones.	ADCY4 ADCY6	4.20e-04	12	89	2	10807185
Pubmed	Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins.	USP38 CSMD3 WDR59	5.76e-04	63	89	3	11572484
Pubmed	Isoforms of mammalian adenylyl cyclase: multiplicities of signaling.	ADCY4 ADCY6	5.78e-04	14	89	2	14993377
Pubmed	TLR3 downregulates expression of schizophrenia gene Disc1 via MYD88 to control neuronal morphology.	DISC1 SHANK3	5.78e-04	14	89	2	27979975
Pubmed	cAMP-dependent protein kinase: framework for a diverse family of regulatory enzymes.	ADCY4 ADCY6	6.65e-04	15	89	2	2165385
Pubmed	Molecular characterization of the ankle-link complex in cochlear hair cells and its role in the hair bundle functioning.	ADCY4 ADCY6	7.59e-04	16	89	2	17567809
Pubmed	Transcription factor TAp73 and microRNA-449 complement each other to support multiciliogenesis.	RFX2 RFX3	8.59e-04	17	89	2	31068677
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	DISC1 FPGS HIP1R FAM91A1 HUWE1 XRCC3 WDR59	9.46e-04	606	89	7	36538041
Pubmed	Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption.	PPM1K TBL2	9.65e-04	18	89	2	25288136
Pubmed	Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes?	SYNE2 TMEM132A HUWE1 ANAPC7	9.74e-04	170	89	4	23314748
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	CEP350 ABCA4 ARHGAP26 SYNE2 IRAK3 RFX1 TBL2	1.27e-03	638	89	7	31182584
Pubmed	Genetic variants associated with disordered eating.	CEP350 TAS2R3 TAS2R38	1.28e-03	83	89	3	23568457
Pubmed	Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair.	SYNE2 HUWE1 SLX4	1.37e-03	85	89	3	19596235
Pubmed	Evolutionary relationships of the Tas2r receptor gene families in mouse and human.	TAS2R3 TAS2R38	1.45e-03	22	89	2	12734386
Pubmed	Identification of proteins interacting with protein arginine methyltransferase 8: the Ewing sarcoma (EWS) protein binds independent of its methylation state.	RASA4 SYNE2	1.58e-03	23	89	2	18320585
Pubmed	The molecular receptive ranges of human TAS2R bitter taste receptors.	TAS2R3 TAS2R38	1.58e-03	23	89	2	20022913
Pubmed	Fanconi Anemia	FANCE SLX4	1.58e-03	23	89	2	20301575
Pubmed	Ubiquitin-conjugating enzyme UBE2O regulates cellular clock function by promoting the degradation of the transcription factor BMAL1.	USP38 HUWE1	1.72e-03	24	89	2	29871923
Pubmed	Avoiding mouse traps in schizophrenia genetics: lessons and promises from current and emerging mouse models.	DISC1 ZDHHC8	1.72e-03	24	89	2	21821099
Pubmed	Receptors for bitter and sweet taste.	TAS2R3 TAS2R38	1.87e-03	25	89	2	12139982
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	LRIG3 SLC4A7 SYNE2 RHBDD3 TMEM214 WDR59	1.89e-03	504	89	6	34432599
Pubmed	siRNA screening identifies differences in the Fanconi anemia pathway in BALB/c-Trp53+/- with susceptibility versus C57BL/6-Trp53+/- mice with resistance to mammary tumors.	FANCE XRCC3	2.02e-03	26	89	2	23435420
Pubmed	Molecular mechanisms of bitter and sweet taste transduction.	TAS2R3 TAS2R38	2.02e-03	26	89	2	11696554
Pubmed	Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways.	TAS2R3 TAS2R38	2.18e-03	27	89	2	12581520
Pubmed	Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	TRIL ARHGAP26 HIP1R	2.32e-03	102	89	3	9734811
Pubmed	A genome-wide screen for spatially restricted expression patterns identifies transcription factors that regulate glial development.	FOXO4 RFX3 TCF7L1	2.32e-03	102	89	3	19741146
Pubmed	Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates.	TAS2R3 TAS2R38	2.34e-03	28	89	2	15744053
Pubmed	N6-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation.	PCNX3 HIP1R BEND3 RFX2	2.38e-03	217	89	4	34048709
Pubmed	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	ARHGEF10 ZBTB5 HUWE1	2.45e-03	104	89	3	9205841
Pubmed	The insulin receptor substrate of 53 kDa (IRSp53) limits hippocampal synaptic plasticity.	ARHGEF7 SHANK3	2.51e-03	29	89	2	19208628
Interaction	PTH2R interactions	AP5Z1 FPGS HIP1R MTFR2 XRCC3 WDR59	1.12e-05	119	85	6	int:PTH2R
Interaction	GNAL interactions	ARHGAP26 SYNE2 SPATA2 SHANK3	1.75e-05	37	85	4	int:GNAL
GeneFamily	Regulatory factor X family	RFX1 RFX2 RFX3	1.83e-06	8	59	3	1153
GeneFamily	Adenylate cyclases\|Deafness associated genes	ADCY4 ADCY6	4.63e-04	10	59	2	53
GeneFamily	Pleckstrin homology domain containing\|SH2 domain containing\|C2 and RasGAP domain containing	RASA4 RASA4B	4.63e-04	10	59	2	830
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ARHGEF10 ARHGEF7 ARHGEF10L	1.31e-03	66	59	3	722
GeneFamily	Ring finger proteins\|Fanconi anemia complementation groups\|Protein phosphatase 1 regulatory subunits\|BRCA1 A complex\|BRCA1 B complex\|BRCA1 C complex	FANCE SLX4	1.92e-03	20	59	2	548
Coexpression	GSE13547_WT_VS_ZFX_KO_BCELL_ANTI_IGM_STIM_12H_UP	RGS20 RASA4 SPHK1 RHBDD3 SYNDIG1 RFX2 TCF7L1	6.57e-07	147	88	7	M2989
ToppCell	5'-Adult-LymphNode-Endothelial-blood_vessel_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADCY4 RASA4 CD300LG RASA4B SHANK3 HYAL2	2.28e-06	190	89	6	141266bf411ea675fbf889b20c1b08673c45ff95
ToppCell	10x5'v1-week_17-19-Endothelial-stroma-proliferating_EC\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	LRIG3 ADCY4 CD300LG TCF7L1 SHANK3 HYAL2	2.35e-06	191	89	6	dc9e5eb6aa31b8d79aeec33e59b9138dfb469a3b
ToppCell	5'-Adult-Distal_Rectal-Endothelial-blood_vessel_EC-Mature_venous_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADCY4 KLK10 RASA4 IRAK3 SHANK3 HYAL2	2.42e-06	192	89	6	eafead22bba48ac5ee568faa8946c444445c1034
ToppCell	LV-09._Endothelium_I\|World / Chamber and Cluster_Paper	ADCY4 SLC9C1 SYNE2 CD300LG SHANK3 HYAL2	2.64e-06	195	89	6	19e0a6c3eae1615aaa39767300acd937dfcb2a7f
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADCY4 ARHGAP26 IRAK3 TCF7L1 SHANK3 HYAL2	2.81e-06	197	89	6	0f467ef58f0c4dcc00b34b7b9639e03fb3ebe780
ToppCell	LV-09._Endothelium_I\|LV / Chamber and Cluster_Paper	ADCY4 SLC9C1 SYNE2 CD300LG SHANK3 HYAL2	2.81e-06	197	89	6	f9731d4d636e51b94a96805eee6afe9aedc175e3
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADCY4 ARHGAP26 IRAK3 TCF7L1 SHANK3 HYAL2	2.89e-06	198	89	6	451003a21162eeae90739fdb502bb50b362d80c8
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADCY4 ARHGAP26 IRAK3 TCF7L1 SHANK3 HYAL2	2.89e-06	198	89	6	440af8f90c7afa1c07000806bcf9110b70f489fb
ToppCell	TCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Adenocarcinoma_Mixed_Subtype-6\|TCGA-Lung / Sample_Type by Project: Shred V9	ADCY4 MS4A6E SIGLEC1 PIK3R5 SHANK3	5.47e-06	126	89	5	b49b15ba1458488f98d54e87100257a12ee34076
ToppCell	PND07-28-samps-Mesenchymal-Myofibroblast-MyoFB-3\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	FANCE HUS1B AVPR1B BEND3 TCF7L1	9.46e-06	141	89	5	7ae8ead02e5aeb4106c4a30c08a7a061da3a5d6a
ToppCell	facs-Lung-Endomucin-24m-Endothelial-Capillary_Type_1_Cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC9C1 CNTNAP5 AVPR1B CSMD3 ADGRF1	1.08e-05	145	89	5	96712c68ab759d7ade0d912581a1a7c25dc6def8
ToppCell	LPS-IL1RA+antiTNF-Unknown-Endothelial-Myofibroblast\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TTC12 TMEM132A CD300LG SYNDIG1 RUNDC1	1.45e-05	154	89	5	16fdafb5c64d2db321554f87129a962d113f1668
ToppCell	5'-GW_trimst-2-LymphNode-Endothelial-blood_vessel_EC-venous_capillary\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADCY4 LINC02908 RASA4 CD300LG SHANK3	2.40e-05	171	89	5	b3e6e31dfe3623b960ccf692fdbd236fa4039923
ToppCell	droplet-Heart-4Chambers-18m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADCY4 RUSC1 CD300LG SHANK3 HYAL2	2.54e-05	173	89	5	9a04271c51fae34f547db3206f9ff5857686e45c
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-Myeloid_Dendritic_Type_1\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASA4 CD300LG SIGLEC1 PPM1K RFX2	2.61e-05	174	89	5	ff13a5c55d18b951315908f33cb47c7f9cb901bf
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Endothelial-blood_vessel_EC-cycling_EC\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADCY4 CD70 CD300LG SHANK3 HYAL2	2.61e-05	174	89	5	42735f6a8e5ec36dd3d35aceea6d37cf3eaa1871
ToppCell	5'-GW_trimst-2-LymphNode-Endothelial-blood_vessel_EC-Mature_venous_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADCY4 RASA4 CD300LG RASA4B HYAL2	2.91e-05	178	89	5	aa44851653d276226b922ee14dd1fc8d1a844cdf
ToppCell	COVID-19-Endothelial_cells-Endothelial_cells_(other)\|COVID-19 / group, cell type (main and fine annotations)	ADCY4 ARHGEF10 SYNE2 SHANK3 HYAL2	3.15e-05	181	89	5	26eb4ee57a70dbf54e096b73129fda9dfda1f6ec
ToppCell	5'-Adult-LymphNode-Endothelial-blood_vessel_EC-Mature_venous_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADCY4 RASA4 RASA4B SHANK3 HYAL2	3.32e-05	183	89	5	a644258ba90acc62d571623e429d72ffc4b69203
ToppCell	5'-GW_trimst-2-LymphNode-Endothelial\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADCY4 RASA4 CD300LG SHANK3 HYAL2	3.40e-05	184	89	5	df2d42e1eae29fa0a1ed9e389c95b38952b46892
ToppCell	5'-GW_trimst-2-LymphNode-Endothelial-blood_vessel_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADCY4 RASA4 CD300LG SHANK3 HYAL2	3.40e-05	184	89	5	1ace70f12b417185bdd46042833f72b3b6815966
ToppCell	COVID-19-kidney-FLT1+PLVAP+EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SLC4A7 ARHGEF7 ARHGAP26 RFX2 SHANK3	3.49e-05	185	89	5	673308ca0514a4d3629d61fe91e9d8fb31b72166
ToppCell	Control-Endothelial_cells-Endothelial_cells_(other)\|Control / group, cell type (main and fine annotations)	ADCY4 ARHGEF10 ARHGAP26 SHANK3 HYAL2	3.59e-05	186	89	5	c6075fe84226b370c5139066793844ad33ae2db1
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP26 IRAK3 TCF7L1 SHANK3 HYAL2	3.68e-05	187	89	5	35c382c0aabd46906113e5db30ea24bb8e658899
ToppCell	3'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADCY4 LINC02908 CD300LG SHANK3 HYAL2	3.68e-05	187	89	5	25efb82afe863a853ecdd781ad89026c993aaa67
ToppCell	Control-Endothelial_cells\|Control / group, cell type (main and fine annotations)	ADCY4 ARHGEF10 ARHGAP26 SHANK3 HYAL2	3.77e-05	188	89	5	3953b08abfea93468fc8d177bdb16ca7c6ffa1ab
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_lymph_vessel-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ADCY4 SPHK1 SLC35E4 SHANK3 HYAL2	3.87e-05	189	89	5	0d18ea72bd58d32a8ab9a61cf97f5786642f804b
ToppCell	COVID-19-Heart-EC_1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ADCY4 SLC9C1 SYNE2 CD300LG SHANK3	3.87e-05	189	89	5	fe49852ba15f948b384d6b4c258927c70b741357
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_lymph_vessel\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ADCY4 ABCA4 SPHK1 SHANK3 HYAL2	3.87e-05	189	89	5	55a1776a4ce049959b3f13a43744c7314bc1f00a
ToppCell	3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ADCY4 SLC9C1 ARHGEF10 CD300LG HYAL2	3.97e-05	190	89	5	d0297d678498e346e56cf95fe9e3db7d3ad3b837
ToppCell	COVID-19-Heart-EC_+_Pericyte\|Heart / Disease (COVID-19 only), tissue and cell type	ADCY4 ARHGEF7 ARHGAP26 SYNE2 SHANK3	3.97e-05	190	89	5	a21653bfb7bafbc273f94fa7c13bfb48cf8fd562
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Inner_Medullary_Collecting_Duct_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC9C1 SLC4A7 HIP1R ADGRF1 TCF7L1	4.07e-05	191	89	5	3e828cffa24ded19f591a7ed6c1fe88ad57fdcac
ToppCell	Control-Myeloid\|Control / group, cell type (main and fine annotations)	DISC1 ARHGAP26 IRAK3 SIGLEC1 PIK3R5	4.07e-05	191	89	5	9c4acc5f3c2f9c0c5520863bb22f391774372347
ToppCell	COVID-19-lung-Macrophage_PPARGhi_CD5Lhi\|lung / Disease (COVID-19 only), tissue and cell type	SLC22A15 IRAK3 SIGLEC1 PIK3R5 ARHGEF10L	4.07e-05	191	89	5	dab953682b8c9ed680a799161f837f792a7e4f33
ToppCell	10x3'2.3-week_14-16-Endothelial-stroma-immature_EC\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	HUS1B CD300LG SYNDIG1 SHANK3 HYAL2	4.17e-05	192	89	5	5af3b2b38495e925497c48f605d618bbf970965d
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADCY4 ARHGAP26 TCF7L1 SHANK3 HYAL2	4.17e-05	192	89	5	1ee4783051ec94ea94600f040edcb385fc4289f1
ToppCell	Adult-Immune-alveolar_macrophage_(MARCO_positive)-D122\|Adult / Lineage, Cell type, age group and donor	SLC22A15 IRAK3 SIGLEC1 PIK3R5 ARHGEF10L	4.27e-05	193	89	5	cc1b6d3bf56e4a88f6fe23dd036a83cf5538c958
ToppCell	Control-Myeloid-Monocyte-derived_macrophages\|Control / group, cell type (main and fine annotations)	DISC1 ARHGAP26 IRAK3 SIGLEC1 PIK3R5	4.27e-05	193	89	5	a6b3bd01e585e2e3fbe9bf693a2e385773123f8e
ToppCell	Adult-Immune-interstitial_macrophage_(C1Q_positive)\|Adult / Lineage, Cell type, age group and donor	DISC1 ARHGAP26 SIGLEC1 PIK3R5 ARHGEF10L	4.27e-05	193	89	5	31c0978ba78c9516d498aec0798902e57555e557
ToppCell	RV-10._Endothelium_II\|World / Chamber and Cluster_Paper	LRIG3 ARHGAP26 SYNE2 IRAK3 SHANK3	4.27e-05	193	89	5	2531266bc57339d4e2b22a88817008e32b8c1598
ToppCell	RV-09._Endothelium_I\|World / Chamber and Cluster_Paper	ADCY4 SLC9C1 SYNE2 CD300LG SHANK3	4.27e-05	193	89	5	e3fa47e2c7cd8a5b69186711c57751f2296de8ae
ToppCell	RV-09._Endothelium_I\|RV / Chamber and Cluster_Paper	ADCY4 SYNE2 CD300LG SHANK3 HYAL2	4.38e-05	194	89	5	7b408096e717f2327c12aea35a8d5fc4621d3b06
ToppCell	10x5'v1-week_17-19-Endothelial\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	ADCY4 CD300LG TCF7L1 SHANK3 HYAL2	4.38e-05	194	89	5	e141beafc9252e5d8c949252bfab53e127c881dc
ToppCell	10x5'v1-week_17-19-Endothelial-stroma\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	ADCY4 CD300LG TCF7L1 SHANK3 HYAL2	4.38e-05	194	89	5	953578102ffc7b612ee8fce45e414750800fef5d
ToppCell	BL-critical-LOC-Epithelial-unknown_epithelial\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	TTC12 RUSC1 GRIN3B TMEM80 ARHGEF10L	4.38e-05	194	89	5	6140ff8e776429c9593607da418b2d9c4f399d41
ToppCell	LA-09._Endothelium_I\|World / Chamber and Cluster_Paper	ADCY4 SLC9C1 SYNE2 SHANK3 HYAL2	4.49e-05	195	89	5	fc95457a298b5d0dab687d9ee7e225a7f7b9a0d4
ToppCell	COVID-19-Myeloid-Monocyte-derived_macrophages\|COVID-19 / group, cell type (main and fine annotations)	DISC1 ARHGAP26 IRAK3 SIGLEC1 PIK3R5	4.49e-05	195	89	5	c172c5599379c29123340621a36bfb1fc90c2115
ToppCell	Immune-alveolar_macrophage_(MARCO_positive)\|World / Lineage, Cell type, age group and donor	SLC22A15 IRAK3 SIGLEC1 PIK3R5 ARHGEF10L	4.49e-05	195	89	5	f92114ef995e690a3bedc62c89c5fd6773d0d9f7
ToppCell	COVID-19-lung-Macrophage_CD163hi_MERTKhi\|lung / Disease (COVID-19 only), tissue and cell type	ARHGAP26 IRAK3 SIGLEC1 PIK3R5 ARHGEF10L	4.49e-05	195	89	5	148fff8c3c9ba45ec36e98dff1be57e3f8294506
ToppCell	3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-capillary_endothelial_cell-EC_general_capillary-EC_general_capillary_L.2.0.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ADCY4 ARHGEF10 SPHK1 CD300LG HYAL2	4.49e-05	195	89	5	a08a3261679f89bb63ca2589d79b6deff716ccad
ToppCell	COVID-19-Heart-EC_1\|Heart / Disease (COVID-19 only), tissue and cell type	ADCY4 SLC9C1 SYNE2 CD300LG SHANK3	4.49e-05	195	89	5	50a193475db1bb1e05b8590225a553688c372c14
ToppCell	CV-Moderate-6\|Moderate / Virus stimulation, Condition and Cluster	CEP350 CD70 HUWE1 PPM1K PIK3R5	4.49e-05	195	89	5	2b8a72d7e755b9655c7a496000d10ff06e50862b
ToppCell	3'-GW_trimst-2-LargeIntestine-Endothelial\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADCY4 SPHK1 CD300LG SHANK3 HYAL2	4.60e-05	196	89	5	9b53e3fdb23dbdfc2e7ce012c6b2ce50700c95d5
ToppCell	COVID-19-kidney-VWF+PLVAP+VCAM1+EC\|kidney / Disease (COVID-19 only), tissue and cell type	ADCY4 ARHGAP26 IRAK3 SHANK3 HYAL2	4.60e-05	196	89	5	ac2c4a325efa8497a755cd31fb6a9d94d8e3bf42
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ADCY4 IRAK3 TCF7L1 SHANK3 HYAL2	4.60e-05	196	89	5	22767bcf0095d9eb0cbed7cdc74e4d32d9357e1b
ToppCell	wk_15-18-Endothelial-Lymph_endothelial\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	ADCY4 ABCA4 SPHK1 SHANK3 HYAL2	4.60e-05	196	89	5	ff627244d7f5fd6a2ec009dae32d3509f0e2d95e
ToppCell	5'-Adult-LargeIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADCY4 KLK10 RASA4 SHANK3 HYAL2	4.71e-05	197	89	5	87eda06344498dc66cac292cf89746dc90b5cf67
ToppCell	Parenchyma_Control_(B.)-Endothelial-TX-Endothelial-1\|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type	ADCY4 RASA4 SYNE2 SHANK3 HYAL2	4.71e-05	197	89	5	f969685dee212f33a6f09e54c0cd1fd24ffef546
ToppCell	Children_(3_yrs)-Immune\|Children_(3_yrs) / Lineage, Cell type, age group and donor	DISC1 ARHGAP26 IRAK3 SIGLEC1 PIK3R5	4.71e-05	197	89	5	f18807124b91310fcd84238484a80ecdba684679
ToppCell	Lung_Parenchyma-Control-Endothelial-Endothelial-Endothelial-1\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	ADCY4 RASA4 SYNE2 SHANK3 HYAL2	4.71e-05	197	89	5	1a137af40697137bb9d2b5caf2b1ffda55f04461
ToppCell	LA-09._Endothelium_I\|LA / Chamber and Cluster_Paper	ADCY4 SLC9C1 SYNE2 SHANK3 HYAL2	4.71e-05	197	89	5	ab6d1ab586a188597a39854ef980b8955ebcc645
ToppCell	Lung_Parenchyma-Control-Endothelial-Endothelial-Endothelial-1-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ADCY4 RASA4 SYNE2 SHANK3 HYAL2	4.71e-05	197	89	5	96d63a8d00583e2aa0a38412e2ae27e23f399493
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADCY4 ARHGAP26 IRAK3 SHANK3 HYAL2	4.83e-05	198	89	5	1378c6d4ceb84b42fdd6556be3296df7a8059e6e
ToppCell	Adult-Immune\|Adult / Lineage, Cell type, age group and donor	DISC1 ARHGAP26 IRAK3 SIGLEC1 PIK3R5	4.83e-05	198	89	5	9bfd7b88aa646eaf5eddb15cf985c7ca910cb35e
ToppCell	IPF-Endothelial-VE_Peribronchial\|Endothelial / Disease state, Lineage and Cell class	SLC4A7 RASA4 SYNE2 RASA4B RFX2	4.83e-05	198	89	5	b8bd1ba268480f54451648e01631b615a3401144
ToppCell	ILEUM-non-inflamed-(7)_ACKR1+_endothelial_cells\|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	ADCY4 KLK10 RASA4 SPHK1 HYAL2	4.83e-05	198	89	5	f8a6a75c9f2fbe32a22b14b6a029411c73c09f68
ToppCell	5'-Adult-SmallIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADCY4 KLK10 RASA4 SHANK3 HYAL2	4.94e-05	199	89	5	07bda4ac8ffdce1a865ebc99e46c2a27925ff7a8
ToppCell	10x_5'_v1-Non-neoplastic-Lymphoid-CD4/CD8-Stress_sig\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ARHGEF7 SYNE2 CD70 PPM1K PTGER2	4.94e-05	199	89	5	f3cc3cda38f78d1d12d865df339d93c5fecf19f2
ToppCell	proximal-Endothelial\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ADCY4 SPHK1 CD300LG SHANK3 HYAL2	5.06e-05	200	89	5	970dac1b11ae8f4adb26634717064289967b4bde
ToppCell	proximal-3-Endothelial\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ADCY4 SPHK1 CD300LG SHANK3 HYAL2	5.06e-05	200	89	5	90c36cfb9632a3bdc9a335b2193f6b08aba35208
ToppCell	proximal-Endothelial-Bronchial_Vessel_2-3\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ADCY4 SPHK1 CD300LG SHANK3 HYAL2	5.06e-05	200	89	5	b6666ade237c39bfde13987685567bad1762baec
ToppCell	proximal-Endothelial-Bronchial_Vessel_2\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ADCY4 SPHK1 CD300LG SHANK3 HYAL2	5.06e-05	200	89	5	2ecf7a38799c151ffb09f2677e38a4ffa354c1da
ToppCell	Bronchial-NucSeq-Immune_Myeloid-Monocytic-Monocyte_CD14\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	LINC02908 DISC1 ARHGAP26 IRAK3 PIK3R5	5.06e-05	200	89	5	5432bdf495431cd26f6e4cd585100f3652588913
ToppCell	proximal-Endothelial-Bronchial_Vessel_1\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ADCY4 RASA4 SPHK1 SHANK3 HYAL2	5.06e-05	200	89	5	d034bd210c87b704acf45f50d888497c8737011b
ToppCell	5'-Adult-SmallIntestine-Endothelial-blood_vessel_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADCY4 KLK10 RASA4 SHANK3 HYAL2	5.06e-05	200	89	5	cd3c638961144a2fc91c437a173cc37c7452fa74
ToppCell	5'-Adult-SmallIntestine-Endothelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADCY4 KLK10 RASA4 SHANK3 HYAL2	5.06e-05	200	89	5	2554b77edfe3d378296b0b25625caacbfb1c0e76
ToppCell	proximal-3-Endothelial-Bronchial_Vessel_1\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ADCY4 RASA4 SPHK1 SHANK3 HYAL2	5.06e-05	200	89	5	0ff4185021ec84b57be13b28495e2f8a4d195eb6
ToppCell	proximal-Endothelial-Bronchial_Vessel_1-3\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ADCY4 RASA4 SPHK1 SHANK3 HYAL2	5.06e-05	200	89	5	e4f6e0b9502eb531f28d605f9dbda6a72a9ed320
ToppCell	proximal-3-Endothelial-Bronchial_Vessel_2\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ADCY4 SPHK1 CD300LG SHANK3 HYAL2	5.06e-05	200	89	5	038812912bb9f6c1359765614bb9fd138843a306
ToppCell	PBMC-Control-Lymphocyte-T/NK-NK_cell-NK_activated\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	ADCY4 SYNE2 CD300LG TCF7L1	9.24e-05	118	89	4	5f72022f4be3fb7ccec86dc05d37572833028886
ToppCell	PBMC-Control-Lymphocyte-T/NK-NK_cell-NK_activated-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	ADCY4 SYNE2 CD300LG TCF7L1	9.24e-05	118	89	4	053c0986051e36fdc4c48b8067c137b6299b2f1b
ToppCell	Control-Lymphoid_T/NK-NK_activated\|Control / Disease group, lineage and cell class	ADCY4 SYNE2 CD300LG TCF7L1	9.55e-05	119	89	4	a258d91ac90d4174b6f203d7f96ba6e57c6003e7
ToppCell	PBMC-Control-Lymphocyte-T/NK-NK_cell-NK_activated\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ADCY4 SYNE2 CD300LG TCF7L1	9.55e-05	119	89	4	28d6b0e9dda2fe4ca94ae9b95b7261618d0d9877
ToppCell	PBMC-Control-Lymphocyte-T/NK-NK_cell-NK_activated-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ADCY4 SYNE2 CD300LG TCF7L1	9.55e-05	119	89	4	0fdd5b093ac20a4bda0f7b623808eb3ad0bf68e2
ToppCell	facs-Lung-EPCAM-3m-Hematologic-leukocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TLR5 CD300LG FOXO4 SIGLEC1	1.79e-04	140	89	4	731b46e4b815a45af1d0ce7ab4d0d0324ac8798f
ToppCell	facs-Lung-EPCAM-3m-Hematologic-Proliferating_Immune\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TLR5 CD300LG FOXO4 SIGLEC1	1.79e-04	140	89	4	b30fc389583406ee6cb55112d0f7250d1b74c88a
ToppCell	facs-Lung-EPCAM-3m-Hematologic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TLR5 CD300LG FOXO4 SIGLEC1	1.79e-04	140	89	4	35ecd887bb7827603ef673912ba820208a6368d2
ToppCell	remission-multiplets\|World / disease stage, cell group and cell class	GRIN3B RFX3 PRRT4 SLC22A31	1.89e-04	142	89	4	286d01b4f95e9c0b38b91958f925f3797dffd596
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Macrophage-macrophage,_alveolar-Macro_c1-C1QC\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	MS4A6E RHBDD3 MTFR2 RFX2	1.99e-04	144	89	4	f769be4da268980ea7c06d7097ec39d06777e675
ToppCell	COVID-19-kidney-Mito-rich_EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ADCY4 SYNE2 TCF7L1 SHANK3	2.04e-04	145	89	4	afed661aef990edb8e7012ab67ace56443520c9f
ToppCell	remission-multiplets\|remission / disease stage, cell group and cell class	ZNF469 GRIN3B PRRT4 SLC22A31	2.27e-04	149	89	4	e9974260a5f2999b363f306cae005698c912893a
ToppCell	(08)_PNEC-(4)_1wkpi\|(08)_PNEC / shred by cell type and Timepoint	USP38 TBL2	2.52e-04	12	89	2	f1b105bcdbe03be6765c820b42c752a24d502212
ToppCell	facs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CNTNAP5 AVPR1B SIGLEC1 CSMD3	3.12e-04	162	89	4	bf886e22ff2a20353499004b53f25fb9e6574896
ToppCell	390C-Endothelial_cells-Endothelial-E\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	DNHD1 HUS1B CD300LG PIK3R5	3.12e-04	162	89	4	45be019b50e3727fc9d3fad2ff78e74e4f2d746b
ToppCell	390C-Endothelial_cells-Endothelial-E-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	DNHD1 HUS1B CD300LG PIK3R5	3.12e-04	162	89	4	fbb0cc2b1434a340dc35058b77c73ea61004c252
ToppCell	normal_Lung-Fibroblasts-Myofibroblasts\|Fibroblasts / Location, Cell class and cell subclass	ZNF469 SPHK1 CD70 SYNDIG1	3.26e-04	164	89	4	9b4a6007abae992db871d9f6f731d5af724de30d
ToppCell	E18.5-samps-Mesenchymal-Matrix_fibroblast-MatrixFB-A\|E18.5-samps / Age Group, Lineage, Cell class and subclass	RGS20 AVPR1B PPM1K PTGER2	3.26e-04	164	89	4	519ab4fe885dfe4c50846f346a062acc2cb44299
ToppCell	10x5'-lymph-node_spleen-Myeloid_Mac-Intermediate_macrophages\|lymph-node_spleen / Manually curated celltypes from each tissue	MS4A6E SPHK1 SIGLEC1 ARHGEF10L	3.34e-04	165	89	4	c3fa9225d2f9c9e821d4fbd2315fcc98ce1f1c55
ToppCell	Hippocampus-Macroglia-POLYDENDROCYTE-P3-Tnr-Polydendrocyte.Tnr.Ptprz1_(Ptprz1)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	ZNF469 DISC1 CD70	3.42e-04	68	89	3	9ce22a6dea3c17d5352572ea0dabe6c6120b9f82
ToppCell	Hippocampus-Macroglia-POLYDENDROCYTE-P3-Tnr-Polydendrocyte.Tnr.Ptprz1_(Ptprz1)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	ZNF469 DISC1 CD70	3.42e-04	68	89	3	89d337147899a978a7467db24e876a613bdd2288
Disease	MYELODYSPLASTIC SYNDROME	FANCE SPHK1 ARHGAP26 SLX4	3.54e-05	67	81	4	C3463824
Disease	melioidosis (is_marker_for)	TLR5 IRAK3	1.11e-04	6	81	2	DOID:5052 (is_marker_for)
Disease	ceramide measurement	LRIG3 SYNE2 SYNDIG1 SLC35E4 GRIN3B	4.81e-04	235	81	5	EFO_0010222
Disease	Fanconi anemia	FANCE SLX4	6.63e-04	14	81	2	cv:C0015625
Disease	Colorectal Carcinoma	ABCA4 FPGS SLC22A15 CSMD3 PIK3R5 PIGO ARHGEF10L PPOX	6.89e-04	702	81	8	C0009402
Disease	schizophrenia (implicated_via_orthology)	DISC1 CSMD3 SHANK3	8.78e-04	68	81	3	DOID:5419 (implicated_via_orthology)
Disease	Bone marrow hypocellularity	FANCE SLX4	1.11e-03	18	81	2	C1855710
Disease	Schizophrenia	DISC1 SHANK3	1.11e-03	18	81	2	cv:C0036341
Disease	Fanconi Anemia	FANCE SLX4	2.14e-03	25	81	2	C0015625
Disease	Pancytopenia	FANCE SLX4	2.32e-03	26	81	2	C0030312
Disease	Acute monocytic leukemia	FANCE SLX4	2.32e-03	26	81	2	C0023465
Disease	triglyceride measurement, response to escitalopram, response to citalopram	CNTNAP5 PIGO	2.50e-03	27	81	2	EFO_0004530, EFO_0006329, EFO_0007871

Protein segments in the cluster

Peptide	Gene	Start	Entry
FTSGSTLRLFHTETL	ARHGEF10	1126	O15013
SSRALSLQLGALVHS	ARHGEF10L	791	Q9HCE6
FSLRLTSDFAVSAHG	CSMD3	151	Q7Z407
SSSSLARIFQLLLSH	ABCA4	2211	P78363
ILSNISSLSLASHFR	ADGRF1	351	Q5T601
LLSLLASSVFLHISS	ADCY6	821	O43306
AAVAGLASSLSHLLV	ADCY4	141	Q8NFM4
SLGSQSLHTRTSKLF	ARHGEF7	156	Q14155
FSGHLSTLRLSFPNL	AP5Z1	421	O43299
AFSSSHLRLLLSRGI	DNHD1	2416	Q96M86
LTTLHRLLALATSGS	DNHD1	2951	Q96M86
SRQPALSSFLGHLAA	DISC1	396	Q9NRI5
ASRSISLLRLSFHQG	CD70	136	P32970
LRAHLGALLSALSRS	RASA4	416	O43374
FSSHARLSADATLLT	PPM1K	171	Q8N3J5
LRAHLGALLSALSRS	RASA4B	416	C9J798
SSLSIGNFASRLLVH	BEND3	566	Q5T5X7
TGLLALHSAALVSRT	ABCD1	91	P33897
AAAGLHSNVRLLSSL	ANAPC7	11	Q9UJX3
FLNASIHAAGTFRLS	OR5B21	151	A6NL26
SHLTSLLALAALAFT	HYAL2	456	Q12891
NHLSRLDDSSFLGLS	LRIG3	321	Q6UXM1
ASSALTLLFGALTSL	ASPHD1	76	Q5U4P2
SSLSLSTGHTKRIAF	FAM91A1	366	Q658Y4
SALHFASSLLLTRAG	PCNX3	631	Q9H6A9
HSLLSRSGLSGFSLQ	FOXO4	316	P98177
GLFSHSGSRQLLFSL	OR2Z1	16	Q8NG97
CSAGRRSSLSLFHVL	PTGER2	56	P43116
GARGALSAHTLLFDL	IRAK3	6	Q9Y616
RLFGHSSTSALSAIL	HUWE1	3111	Q7Z6Z7
FFLSHLALTDISLSS	OR1J4	61	Q8NGS1
SALVAALTRFSHLAA	HIP1R	686	O75146
RLAGSLATDLSRSHS	LINC02908	91	Q6ZV77
ALAAALAHISGASSF	DDX50	561	Q9BQ39
FAGTAGSLLSHLLSL	CEP350	751	Q5VT06
HSSLAGSILSALSAL	MS4A6E	51	Q96DS6
HLSRAARSAAGASSL	HUS1B	86	Q8NHY5
SHLRAALFLAAASAR	FPGS	6	Q05932
SLFLGRILSLTSSAS	FANCE	366	Q9HB96
GLRQALLSSHRFSGA	C1orf159	326	Q96HA4
HSLSLLGKLTISAAF	SLC22A15	401	Q8IZD6
GLLASRAVSALSSLF	SLC22A31	431	A6NKX4
HLNLGDSKARLSSSL	CNTNAP5	241	Q8WYK1
RLSGACLTSIAAHAF	LINGO4	306	Q6UY18
LLLSLLAHFTGSVAS	IGLV3-9	6	A0A075B6K5
LLSSLGEHAFFRLAL	GRIN3B	846	O60391
AHTGFESALNLLSRL	RUNDC1	576	Q96C34
SSRSRFHAFILGLLN	RUSC1	591	Q9BVN2
SISRLFLHGLLFLSA	TAS2R38	61	P59533
ASRHSLRTGLSASNL	SLC4A7	256	Q9Y6M7
TLSLISSIGAFLNRH	SLC9C1	21	Q4G0N8
SLASYSLLIFSLGRH	TAS2R3	196	Q9NYW6
ALTAGTALLSAHFLL	TMEM80	166	Q96HE8
FSATLLLRHNFTASL	TMEM132A	271	Q24JP5
NLFRFLTDTSHLLSA	SYNE2	5711	Q8WXH0
LHQASTSSRRALFLA	SYNDIG1	216	Q9H7V2
LRSAASFGSFHLIRL	RFX1	866	P22670
DLTLRSAASFGSFHL	RFX2	626	P48378
DLTLRSAASFGSFHL	RFX3	611	P48380
SSPLSSLARFFSHLL	RGS20	76	O76081
SLARSSLHAVFSLLV	ARHGAP26	716	Q9UNA1
LSSELSSLAHRFGVS	SLX4	766	Q8IY92
LSLLSAAGLIAFCSH	CD300LG	256	Q6UXG3
TLRFLHASALLALAS	RHBDD3	86	Q9Y3P4
HASALLALASGLLAV	RHBDD3	91	Q9Y3P4
FLTAHRLPLTLAGAS	PPOX	436	P50336
SLSSSSLRALHGAFS	SPATA2	76	Q9UM82
RLSDGSLSSRHTTLL	AVPR1B	366	P47901
FSRSGLGLHSSFSRV	ZBTB5	506	O15062
LSRHLLTSFVSGLSD	PIK3R5	371	Q8WYR1
IAAARLFSSLGELSS	SHANK3	1531	Q9BYB0
TRAQLALHSAAFLSA	TCF7L1	511	Q9HCS4
HSSVSSGLLRLSIFL	RNF148	11	Q8N7C7
HAATFAPLRSLSSLI	TRIL	221	Q7L0X0
LRSHSSFQASLTGRL	TMEM214	501	Q6NUQ4
LASRGLHAFLAAFLS	PRRT4	496	C9JH25
AQLALSHAGRLLASS	SIGLEC1	1201	Q9BZZ2
AASLSFLVATRAHAG	SIGLEC1	1306	Q9BZZ2
LASLTLHLGSRLVAS	SIGLEC1	1561	Q9BZZ2
LALASSQSHLLGRDS	USP38	881	Q8NB14
ISLGQLSSSRAAHLS	MTFR2	181	Q6P444
ESLALALTAAHSRSG	ZNF469	2036	Q96JG9
RSLSALSAYHTGLIA	WDR59	571	Q6PJI9
FALLLHLAQTESGRS	TTC12	361	Q9H892
SASDAFSGALRSLSL	ZDHHC8	421	Q9ULC8
SGFLLTRLELTNHSS	PIGO	26	Q8TEQ8
ASFSLLALTSALTVH	SLC35E4	271	Q6ICL7
NLLSLHTASGLRLFS	SPHK1	151	Q9NYA1
HTASGLRLFSVLSLA	SPHK1	156	Q9NYA1
VFSHLTALRGLSLNS	TLR5	521	O60602
SFSLTSNLSRAHLEL	VWA7	766	Q9Y334
LALASGSSIHLYNTR	TBL2	346	Q9Y4P3
RTASLHLRGSSILTA	XRCC3	51	O43542
LHLSAASGARALAKL	KLK10	6	O43240