Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	HSA	SMARCA2 SRCAP	2.41e-05	4	38	2	SM00573
Domain	HSA	SMARCA2 SRCAP	2.41e-05	4	38	2	PS51204
Domain	HSA_dom	SMARCA2 SRCAP	2.41e-05	4	38	2	IPR014012
Domain	HSA	SMARCA2 SRCAP	2.41e-05	4	38	2	PF07529
Domain	SNF2_N	SMARCA2 SRCAP	1.92e-03	32	38	2	PF00176
Domain	SNF2_N	SMARCA2 SRCAP	1.92e-03	32	38	2	IPR000330
Domain	UBA-like	NT5C2 NSFL1C	7.51e-03	64	38	2	IPR009060
Domain	-	NT5C2 CTDP1	7.51e-03	64	38	2	3.40.50.1000
Domain	HAD-like_dom	NT5C2 CTDP1	1.13e-02	79	38	2	IPR023214
Pubmed	ASK1 associates with troponin T and induces troponin T phosphorylation and contractile dysfunction in cardiomyocytes.	TNNT2 MAP3K5	1.16e-06	2	38	2	12819028
Pubmed	BioID-based Identification of Skp Cullin F-box (SCF)β-TrCP1/2 E3 Ligase Substrates.	STK3 CREBRF ZC3H18 NSFL1C NRDC	4.67e-06	226	38	5	25900982
Pubmed	Brahma safeguards canalization of cardiac mesoderm differentiation.	SMARCA2 TNNT2	6.96e-06	4	38	2	35082446
Pubmed	Threonine 74 of MOB1 is a putative key phosphorylation site by MST2 to form the scaffold to activate nuclear Dbf2-related kinase 1.	STK3 NRDC	1.16e-05	5	38	2	18362890
Pubmed	Confirmation of top polymorphisms in hypertension genome wide association study among Han Chinese.	NT5C2 ZNF652	1.74e-05	6	38	2	20542020
Pubmed	Hippo pathway-dependent and -independent roles of RASSF6.	STK3 NRDC	3.24e-05	8	38	2	19797269
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	ZC3H18 SRCAP NSFL1C KAT6B NOC2L	3.39e-05	341	38	5	32971831
Pubmed	Nebulette knockout mice have normal cardiac function, but show Z-line widening and up-regulation of cardiac stress markers.	WASL TNNT2	1.38e-04	16	38	2	25987543
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	SRCAP CELSR2 IFNLR1 MAP3K5 KSR2 ZNF316 CTDP1	1.71e-04	1105	38	7	35748872
Pubmed	Discovery and replication of novel blood pressure genetic loci in the Women's Genome Health Study.	NT5C2 ZNF652	1.76e-04	18	38	2	21045733
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	SMARCA2 ZC3H18 DCAF8 SRCAP KAT6B DNTTIP2 ZNF316	1.82e-04	1116	38	7	31753913
Pubmed	Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry.	HRC MAP3K5	1.96e-04	19	38	2	12543931
Pubmed	Single-cell transcriptomic analysis identifies murine heart molecular features at embryonic and neonatal stages.	ADAMTS8 TNNT2	2.65e-04	22	38	2	36575170
Pubmed	Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.	SMARCA2 ZC3H18 NOC2L DNTTIP2 MAP3K5	2.74e-04	533	38	5	30554943
Pubmed	Genome-wide association study identifies eight loci associated with blood pressure.	NT5C2 ZNF652	5.65e-04	32	38	2	19430483
Pubmed	HIV-1 Vpr induces cell cycle arrest and enhances viral gene expression by depleting CCDC137.	ZC3H18 NSFL1C DNTTIP2	5.71e-04	148	38	3	32538781
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	NT5C2 CACNA1A CELSR2 KIF21A MAP3K5 KSR2	5.74e-04	963	38	6	28671696
Pubmed	Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder.	NT5C2 ZDBF2	6.76e-04	35	38	2	22688191
Pubmed	The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.	SMARCA2 SRCAP KAT6B	6.78e-04	157	38	3	30186101
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	SMARCA2 TSR2 ZC3H18 NSFL1C NRDC GPN1	7.18e-04	1005	38	6	19615732
Pubmed	Analysis of the SWI/SNF chromatin-remodeling complex during early heart development and BAF250a repression cardiac gene transcription during P19 cell differentiation.	SMARCA2 TNNT2	7.56e-04	37	38	2	24335282
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	CREBRF SRCAP SPOCK1 NOC2L DNTTIP2 KIF21A DDX11	8.47e-04	1442	38	7	35575683
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	SECISBP2L STK3 DCAF8 NOC2L MEX3C GPN1	8.50e-04	1038	38	6	26673895
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	NT5C2 DCAF8 NSFL1C NRDC ACBD3 KIF21A GPN1	8.93e-04	1455	38	7	22863883
Pubmed	Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.	NT5C2 ZNF652	9.74e-04	42	38	2	21909110
Cytoband	1p36.22	PEX14 CLSTN1	4.36e-04	37	38	2	1p36.22
Cytoband	Ensembl 112 genes in cytogenetic band chr1p36	PEX14 CLSTN1 NOC2L IFNLR1	2.37e-03	681	38	4	chr1p36
Coexpression	GSE20727_H2O2_VS_ROS_INHIBITOR_TREATED_DC_UP	CREBRF TSR2 WASL ACBD3 ZNF652	9.82e-06	199	38	5	M9255
Coexpression	BAELDE_DIABETIC_NEPHROPATHY_DN	SMARCA2 PEX14 DCAF8 TNNT2 SPOCK1 ACBD3	3.65e-05	437	38	6	M4665
Coexpression	ENK_UV_RESPONSE_KERATINOCYTE_DN	SMARCA2 STK3 DCAF8 CELSR2 ACBD3 MAP3K5	6.21e-05	481	38	6	M3898
Coexpression	HEVNER_CORTEX_APICAL_AND_BASAL_INTERMEDIATE_PROGENITOR_CELLS	KAT6B NEUROD4 KIF21A	7.00e-05	55	38	3	MM397
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_top-relative-expression-ranked_1000_k-means-cluster#2	CACNA1A ZDBF2 CELSR2 KAT6B DNTTIP2 KIF21A	2.36e-05	328	38	6	Facebase_RNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_1000_K2
CoexpressionAtlas	FacebaseRNAseq_ratio_e10.5_MaxillaryArch_vs_Mandibular_top-relative-expression-ranked_1000_k-means-cluster#1	NT5C2 CREBRF CACNA1A CELSR2 RSPH4A	8.72e-05	255	38	5	Facebase_RNAseq_ratio_e10.5_MaxillaryArch_vs_Mandibular_1000_K1
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_top-relative-expression-ranked_2500_k-means-cluster#5	NT5C2 CACNA1A ZDBF2 CELSR2 KAT6B DNTTIP2 KIF21A	1.40e-04	654	38	7	Facebase_RNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_2500_K5
CoexpressionAtlas	FacebaseRNAseq_ratio_e10.5_MaxillaryArch_vs_Mandibular_top-relative-expression-ranked_500	NT5C2 SMARCA2 CREBRF CACNA1A ZBTB47 CELSR2	2.16e-04	490	38	6	Facebase_RNAseq_ratio_e10.5_MaxillaryArch_vs_Mandibular_500
CoexpressionAtlas	FacebaseRNAseq_ratio_e10.5_MaxillaryArch_vs_Mandibular_top-relative-expression-ranked_1000	NT5C2 SMARCA2 CREBRF CACNA1A ZBTB47 CELSR2 RSPH4A MAP3K5	2.71e-04	973	38	8	Facebase_RNAseq_ratio_e10.5_MaxillaryArch_vs_Mandibular_1000
CoexpressionAtlas	FacebaseRNAseq_e8.5_Non-Floor Plate Neural Epithelium_top-relative-expression-ranked_2500_k-means-cluster#5	NT5C2 CREBRF CACNA1A CELSR2 RSPH4A KIF21A ZNF316	2.79e-04	732	38	7	Facebase_RNAseq_e8.5_Non-Floor Plate Neural Epithelium_2500_K5
ToppCell	Control_saline-Epithelial_alveolar-AT_1-Differentiating_AT2\|Control_saline / Treatment groups by lineage, cell group, cell type	SECISBP2L RSPH4A IFNLR1 KIF21A GPN1	7.36e-07	200	38	5	eac33be484dc443794e66e473f03e98406c2983e
Drug	Kanamycin A sulfate [25389-94-0]; Down 200; 6.8uM; HL60; HG-U133A	SECISBP2L PEX14 DCAF8 KAT6B MAP3K5 CTDP1	8.78e-07	198	38	6	1609_DN
Drug	Verapamyl hydrochloride [152-11-4]; Down 200; 8.2uM; HL60; HG-U133A	SMARCA2 STK3 PEX14 ZNF652 CTDP1	1.70e-05	194	38	5	2009_DN
Drug	Phenformin hydrochloride [834-28-6]; Down 200; 16.6uM; MCF7; HT_HG-U133A	SECISBP2L NSFL1C NEUROD4 MAP3K5 CTDP1	1.79e-05	196	38	5	4747_DN
Drug	Ramipril [87333-19-5]; Down 200; 9.6uM; MCF7; HT_HG-U133A	STK3 SRCAP KAT6B ZNF652 MAP3K5	1.83e-05	197	38	5	6792_DN
Disease	angina pectoris	NT5C2 CELSR2 ZNF652	5.62e-04	125	38	3	EFO_0003913
Disease	migraine disorder	NT5C2 CACNA1A WASL KSR2	1.12e-03	357	38	4	MONDO_0005277
Disease	Small cell carcinoma of lung	ZDBF2 KIF21A	2.22e-03	54	38	2	C0149925

Protein segments in the cluster

Peptide	Gene	Start	Entry
EDEDSDEDEFQITEH	CACNA1A	1721	O00555
MEEEEEEDTDEDDHL	CTDP1	576	Q9Y5B0
HCHDEDDDEEEEEEE	NT5C2	546	P49902
EHELSENEEEEEEEE	CREBRF	376	Q8IUR6
DHQEDSEEESQEEEA	ADAMTS8	181	Q9UP79
STHSSDSEEEEEEEE	CELSR2	2736	Q9HCU4
QHSSEEEEEEEEEEE	CLSTN1	921	O94985
DSARLDDHEEEEEED	KAT6B	1401	Q8WYB5
DDHEEEEEEDEEPSH	KAT6B	1406	Q8WYB5
EEEEDEEPSHNEDHD	KAT6B	1411	Q8WYB5
EEEEEARESEIEDSD	IFNLR1	481	Q8IU57
SENEEVHDEAEESED	KSR2	616	Q6VAB6
DENRVHDRSEEEEEE	DCAF8	91	Q5TAQ9
HDRSEEEEEEEEEEE	DCAF8	96	Q5TAQ9
HVSESSDDDEEEEEN	ACBD3	446	Q9H3P7
ASRVDEDEDDLEEEH	DDX11	211	Q96FC9
RDLIHDQDEDEEEEE	NSFL1C	76	Q9UNZ2
STRHGVEDDEEDEEE	NOC2L	691	Q9Y3T9
EEDEEADSDTDDIDH	GPN1	331	Q9HCN4
TADQEDLDVEDDHEE	MAP3K5	1186	Q99683
RDNGESEAHEDEEDE	RSPH4A	391	Q5TD94
SNEEEEEEDEEESES	SMARCA2	1516	P51531
EEEELEEAEEEDRSS	MEX3C	126	Q5U5Q3
EEDEDEEEEEDYTHE	SECISBP2L	991	Q93073
HSEEEEEEEEGLEED	HRC	566	P23327
EDRSEDEEDEHSEEE	SRCAP	501	Q6ZRS2
EEDEEDDDVSHVDEE	PEX14	326	O75381
EEEEDEKSEEDSSDH	DNTTIP2	521	Q5QJE6
EEEENSDEDELDSHT	STK3	311	Q13188
RETDEDEDDVDSVEE	TSR2	131	Q969E8
VEESQEVSDHEDEEE	KIF21A	601	Q7Z4S6
EVSDHEDEEEEEEEE	KIF21A	606	Q7Z4S6
AETEETRAEEDEEEE	TNNT2	46	P45379
HTRAVTEDDEDEDDD	SPOCK1	416	Q08629
HLDDAFSEEEEEDED	ZDBF2	81	Q9HCK1
EHDDDLDTEDNELEE	NRDC	181	O43847
EEEEDGHSEQEEEEE	ZBTB47	316	Q9UFB7
GHSEQEEEEEEEEEE	ZBTB47	321	Q9UFB7
TDDIEDHEEEDDEDF	ZNF316	241	A6NFI3
AIHSSDEDEDEDDEE	WASL	481	O00401
DRENSDDTEEEEEEV	ZNF652	96	Q9Y2D9
SEEEEEESEEEATDD	ZNF652	151	Q9Y2D9
EEEDNHSDEEDRASE	ZC3H18	61	Q86VM9
HDSIEEEEEEEEDGE	NEUROD4	51	Q9HD90