Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionH3K27me3 modified histone binding

TAF1 HDGFL2

4.10e-055412GO:0061628
GeneOntologyMolecularFunctionchromatin binding

TPR GTF2F1 URI1 TAF1 SETSIP HNRNPC CHAF1A TSPYL2

1.10e-04739418GO:0003682
GeneOntologyMolecularFunctionrDNA binding

BNC2 TSPYL2

1.83e-0410412GO:0000182
GeneOntologyMolecularFunctiongeneral transcription initiation factor binding

GTF2F1 TAF1 CAND1

3.07e-0464413GO:0140296
GeneOntologyMolecularFunctionbasal RNA polymerase II transcription machinery binding

GTF2F1 URI1 TAF1

3.36e-0466413GO:0001099
GeneOntologyMolecularFunctionbasal transcription machinery binding

GTF2F1 URI1 TAF1

3.36e-0466413GO:0001098
GeneOntologyMolecularFunctionRNA polymerase II general transcription initiation factor binding

GTF2F1 TAF1

1.40e-0327412GO:0001091
GeneOntologyBiologicalProcessprotein-DNA complex organization

TPR TAF1 CAND1 UTP3 HUWE1 UBR5 SETSIP BAZ2B HDGFL2 HNRNPC CHAF1A TSPYL2

3.35e-079994112GO:0071824
GeneOntologyBiologicalProcesschromatin organization

TPR TAF1 UTP3 HUWE1 UBR5 SETSIP BAZ2B HDGFL2 HNRNPC CHAF1A TSPYL2

9.33e-078964111GO:0006325
GeneOntologyBiologicalProcesschromatin remodeling

TPR TAF1 HUWE1 UBR5 SETSIP BAZ2B HDGFL2 HNRNPC CHAF1A TSPYL2

1.38e-067414110GO:0006338
GeneOntologyBiologicalProcessprotein-DNA complex assembly

TAF1 CAND1 SETSIP CHAF1A TSPYL2

1.29e-04249415GO:0065004
GeneOntologyBiologicalProcessregulation of enamel mineralization

DMP1 DSPP

1.72e-0410412GO:0070173
GeneOntologyBiologicalProcessmitotic spindle midzone assembly

KIF4A KIF4B

2.10e-0411412GO:0051256
GeneOntologyBiologicalProcessmitotic spindle elongation

KIF4A KIF4B

2.51e-0412412GO:0000022
GeneOntologyBiologicalProcessspindle midzone assembly

KIF4A KIF4B

3.46e-0414412GO:0051255
GeneOntologyBiologicalProcessspindle elongation

KIF4A KIF4B

3.46e-0414412GO:0051231
GeneOntologyBiologicalProcessregulation of tooth mineralization

DMP1 DSPP

3.98e-0415412GO:0070170
MousePhenoincreased dendritic spine number

KIF4A KIF4B

1.93e-053362MP:0021019
MousePhenoabnormal osteocyte canaliculus morphology

DMP1 DSPP

1.93e-053362MP:0030486
MousePhenoabnormal predentin morphology

DMP1 DSPP

6.42e-055362MP:0030543
MousePhenoabnormal osteocyte lacuna morphology

DMP1 DSPP

9.61e-056362MP:0030484
MousePhenoabnormal cementum morphology

DMP1 DSPP

9.61e-056362MP:0003933
MousePhenobehavioral developmental delay

KIF4A KIF4B

1.79e-048362MP:0021165
MousePhenoabnormal dentin mineralization

DMP1 DSPP

2.30e-049362MP:0030451
MousePhenoabnormal dendritic spine number

KIF4A KIF4B

2.86e-0410362MP:0021017
MousePhenoabnormal oligodendrocyte morphology

HIVEP2 PTPRZ1 EIF2B5

3.00e-0451363MP:0000953
MousePhenoalveolar process atrophy

DMP1 DSPP

3.50e-0411362MP:0030466
MousePhenoabnormal periodontal ligament morphology

DMP1 DSPP

4.94e-0413362MP:0003668
DomainPrefoldin

TPR KIF4A URI1

4.90e-0472403IPR009053
DomainNAP

SETSIP TSPYL2

5.96e-0417402PF00956
DomainNAP_family

SETSIP TSPYL2

5.96e-0417402IPR002164
DomainBromodomain_CS

TAF1 BAZ2B

1.41e-0326402IPR018359
DomainHECT

HUWE1 UBR5

1.52e-0327402PF00632
DomainHECTc

HUWE1 UBR5

1.52e-0327402SM00119
DomainHECT_dom

HUWE1 UBR5

1.52e-0327402IPR000569
DomainHECT

HUWE1 UBR5

1.52e-0327402PS50237
DomainBROMODOMAIN_1

TAF1 BAZ2B

2.84e-0337402PS00633
DomainBromodomain

TAF1 BAZ2B

2.99e-0338402PF00439
DomainBROMODOMAIN_2

TAF1 BAZ2B

3.48e-0341402PS50014
DomainKinesin_motor_CS

KIF4A KIF4B

3.48e-0341402IPR019821
DomainBROMO

TAF1 BAZ2B

3.65e-0342402SM00297
DomainBromodomain

TAF1 BAZ2B

3.65e-0342402IPR001487
Domain-

TAF1 BAZ2B

3.65e-03424021.20.920.10
DomainKinesin-like_fam

KIF4A KIF4B

3.82e-0343402IPR027640
DomainKINESIN_MOTOR_1

KIF4A KIF4B

4.00e-0344402PS00411
Domain-

KIF4A KIF4B

4.00e-03444023.40.850.10
DomainKinesin_motor_dom

KIF4A KIF4B

4.00e-0344402IPR001752
DomainKinesin

KIF4A KIF4B

4.00e-0344402PF00225
DomainKISc

KIF4A KIF4B

4.00e-0344402SM00129
DomainKINESIN_MOTOR_2

KIF4A KIF4B

4.00e-0344402PS50067
DomainARM-type_fold

CAND1 HUWE1 ZBTB7C EIF2B5

5.82e-03339404IPR016024
Pubmed

Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.

TPR KIF4A GTF2F1 URI1 CAND1 HUWE1 NRDC UBR5 P4HB HDGFL2 METAP2 HNRNPC EFTUD2

4.82e-091415411328515276
Pubmed

Defining the human deubiquitinating enzyme interaction landscape.

WRNIP1 BOP1 STRN EIF2AK4 CAND1 HIVEP2 HUWE1 NRDC UBR5 DDX10 EFTUD2

1.59e-081005411119615732
Pubmed

Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme.

TPR GTF2F1 URI1 TAF1 CAND1 UBR5 HNRNPC EFTUD2

1.61e-0839041817643375
Pubmed

Systematic identification of factors for provirus silencing in embryonic stem cells.

CAND1 HUWE1 NRDC UBR5 CHAF1A EFTUD2

2.60e-0815341626365490
Pubmed

The in vivo Interaction Landscape of Histones H3.1 and H3.3.

ERICH1 KIF4A BOP1 TAF1 BAZ2B HDGFL2 METAP2 CHAF1A DDX10

3.06e-0860841936089195
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

TPR KIF4A BOP1 CAND1 HUWE1 UBR5 P4HB METAP2 HNRNPC EIF2B5 DDX10 EFTUD2

3.17e-081353411229467282
Pubmed

Unusual chromatin status and organization of the inactive X chromosome in murine trophoblast giant cells.

KIF4A KIF4B HUWE1

5.30e-08741323362347
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

TPR BOP1 CAND1 UTP3 HUWE1 NRDC P4HB HNRNPC CHAF1A EIF2B5 DDX10 EFTUD2

5.60e-081425411230948266
Pubmed

Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.

TPR KIF4A TAF1 HUWE1 P4HB CHAF1A EFTUD2

1.15e-0733241732786267
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

TPR KIF4A TAF1 UTP3 BAZ2B HDGFL2 HNRNPC CHAF1A DDX10 EFTUD2

1.19e-07954411036373674
Pubmed

MYC multimers shield stalled replication forks from RNA polymerase.

WRNIP1 KIF4A BOP1 UTP3 HUWE1 P4HB HNRNPC CHAF1A DDX10 EFTUD2

1.66e-07989411036424410
Pubmed

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.

WRNIP1 TPR KIF4A BOP1 GTF2F1 TAF1 CAND1 UBR5 HDGFL2 CHAF1A

2.09e-071014411032416067
Pubmed

Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.

WRNIP1 TPR KIF4A CAND1 HUWE1 ZBTB7C HNRNPC EFTUD2

3.44e-0758241820467437
Pubmed

Nuclear lamina genetic variants, including a truncated LAP2, in twins and siblings with nonalcoholic fatty liver disease.

EIF2AK4 CAND1 HUWE1 P4HB HNRNPC EFTUD2

4.10e-0724441628902428
Pubmed

Nucleolar proteome dynamics.

TPR BOP1 GTF2F1 UTP3 HNRNPC DDX10 EFTUD2

5.53e-0741941715635413
Pubmed

A high-throughput approach for measuring temporal changes in the interactome.

WRNIP1 BOP1 GTF2F1 CAND1 HUWE1 NRDC SETSIP P4HB HDGFL2 METAP2 EFTUD2

6.56e-071455411122863883
Pubmed

Targeted and Interactome Proteomics Revealed the Role of PHD2 in Regulating BRD4 Proline Hydroxylation.

KIF4A BOP1 GTF2F1 HDGFL2 HNRNPC DDX10 EFTUD2

7.79e-0744141731239290
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

KIF4A BOP1 STRN GTF2F1 CAND1 UTP3 AFTPH P4HB HDGFL2 CHAF1A DDX10

8.68e-071497411131527615
Pubmed

Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells.

WRNIP1 TPR BOP1 CAND1 HUWE1 HDGFL2 HNRNPC EFTUD2

9.38e-0766541830457570
Pubmed

Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.

TPR KIF4A TAF1 UTP3 HDGFL2 DDX10

9.74e-0728341630585729
Pubmed

TAFII250 is a bipartite protein kinase that phosphorylates the base transcription factor RAP74.

GTF2F1 TAF1

1.36e-0624128625415
Pubmed

KIF4 regulates neuronal morphology and seizure susceptibility via the PARP1 signaling pathway.

KIF4A KIF4B

1.36e-06241236482480
Pubmed

Transgenic expression of Dspp partially rescued the long bone defects of Dmp1-null mice.

DMP1 DSPP

1.36e-06241226686820
Pubmed

KIF4 regulates midzone length during cytokinesis.

KIF4A KIF4B

1.36e-06241221565503
Pubmed

DMP1 mutations in autosomal recessive hypophosphatemia implicate a bone matrix protein in the regulation of phosphate homeostasis.

DMP1 DSPP

1.36e-06241217033625
Pubmed

Whole genome expression microarray reveals novel roles for Kif4 in monocyte/macrophage cells.

KIF4A KIF4B

1.36e-06241231486502
Pubmed

Assignment of the kinesin family member 4 genes (KIF4A and KIF4B) to human chromosome bands Xq13.1 and 5q33.1 by in situ hybridization.

KIF4A KIF4B

1.36e-06241210773663
Pubmed

A novel microtubule-based motor protein (KIF4) for organelle transports, whose expression is regulated developmentally.

KIF4A KIF4B

1.36e-0624127929562
Pubmed

Dentin matrix protein 1 regulates dentin sialophosphoprotein gene transcription during early odontoblast differentiation.

DMP1 DSPP

1.36e-06241216679514
Pubmed

The multiple functions of kinesin-4 family motor protein KIF4 and its clinical potential.

KIF4A KIF4B

1.36e-06241230081192
Pubmed

Missense Pathogenic variants in KIF4A Affect Dental Morphogenesis Resulting in X-linked Taurodontism, Microdontia and Dens-Invaginatus.

KIF4A KIF4B

1.36e-06241231616463
Pubmed

Kinase activity and phosphorylation of the largest subunit of TFIIF transcription factor.

GTF2F1 TAF1

1.36e-06241210428810
Pubmed

The rescue of dentin matrix protein 1 (DMP1)-deficient tooth defects by the transgenic expression of dentin sialophosphoprotein (DSPP) indicates that DSPP is a downstream effector molecule of DMP1 in dentinogenesis.

DMP1 DSPP

1.36e-06241223349460
Pubmed

Structural basis for the ATP-induced isomerization of kinesin.

KIF4A KIF4B

1.36e-06241223500491
Pubmed

Chromokinesin Kif4 promotes proper anaphase in mouse oocyte meiosis.

KIF4A KIF4B

1.36e-06241231067151
Pubmed

Dentin matrix protein 1 and dentin sialophosphoprotein in human sound and carious teeth: an immunohistochemical and colorimetric assay.

DMP1 DSPP

1.36e-06241224441185
Pubmed

Kif4 regulates the expression of VEGFR1 through the PI3K/Akt signaling pathway in RAW264.7 monocytes/macrophages.

KIF4A KIF4B

1.36e-06241228350061
Pubmed

Dentin sialoprotein and dentin phosphoprotein overexpression during amelogenesis.

DMP1 DSPP

1.36e-06241216014627
Pubmed

Binding of murine leukemia virus Gag polyproteins to KIF4, a microtubule-based motor protein.

KIF4A KIF4B

1.36e-0624129658142
Pubmed

Cellular motor protein KIF-4 associates with retroviral Gag.

KIF4A KIF4B

1.36e-06241210559369
Pubmed

Gene expression patterns of murine dentin matrix protein 1 (Dmp1) and dentin sialophosphoprotein (DSPP) suggest distinct developmental functions in vivo.

DMP1 DSPP

1.36e-0624129421236
Pubmed

Kif4 interacts with EB1 and stabilizes microtubules downstream of Rho-mDia in migrating fibroblasts.

KIF4A KIF4B

1.36e-06241224658398
Pubmed

BPA modulates the WDR5/TET2 complex to regulate ERβ expression in eutopic endometrium and drives the development of endometriosis.

TPR BOP1 GTF2F1 P4HB HDGFL2 METAP2 HNRNPC EIF2B5

1.54e-0671141833022573
Pubmed

Large-scale mapping of human protein-protein interactions by mass spectrometry.

KIF4A BOP1 STRN UBR5 P4HB HDGFL2 HNRNPC CHAF1A EIF2B5 EFTUD2

1.79e-061284411017353931
Pubmed

A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

TPR KIF4A BOP1 GTF2F1 HUWE1 AFTPH CHAF1A

1.87e-0650341716964243
Pubmed

Functional specialization of beta-arrestin interactions revealed by proteomic analysis.

EIF2AK4 UBR5 P4HB HDGFL2 HNRNPC EFTUD2

1.88e-0631741617620599
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

TPR BOP1 CAND1 HUWE1 UBR5 P4HB HNRNPC DDX10 EFTUD2

2.41e-06102441924711643
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

WRNIP1 TPR HUWE1 AFTPH HNRNPC CHAF1A EIF2B5 EFTUD2

2.90e-0677441815302935
Pubmed

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.

ERICH1 ANKRD26 KIF4A CAND1 HUWE1 UBR5 DMXL1 EFTUD2

2.98e-0677741835844135
Pubmed

The Deubiquitinase USP37 Regulates Chromosome Cohesion and Mitotic Progression.

WRNIP1 TAF1 HNRNPC EFTUD2

2.99e-068441426299517
Pubmed

Identification of the human homologue of mouse KIF4, a kinesin superfamily motor protein.

KIF4A KIF4B

4.06e-06341210978527
Pubmed

EFTUD2 Is a Novel Innate Immune Regulator Restricting Hepatitis C Virus Infection through the RIG-I/MDA5 Pathway.

IFIH1 EFTUD2

4.06e-06341225878102
Pubmed

Renal expression of SIBLING proteins and their partner matrix metalloproteinases (MMPs).

DMP1 DSPP

4.06e-06341215954904
Pubmed

KIF4 motor regulates activity-dependent neuronal survival by suppressing PARP-1 enzymatic activity.

KIF4A KIF4B

4.06e-06341216630823
Pubmed

Expression of SIBLINGs and their partner MMPs in salivary glands.

DMP1 DSPP

4.06e-06341215329369
Pubmed

TGF beta-1 downregulates DMP-1 and DSPP in odontoblasts.

DMP1 DSPP

4.06e-06341212489180
Pubmed

Deletion of dentin matrix protein-1 leads to a partial failure of maturation of predentin into dentin, hypomineralization, and expanded cavities of pulp and root canal during postnatal tooth development.

DMP1 DSPP

4.06e-06341214966118
Pubmed

CircKIF4A enhances osteosarcoma proliferation and metastasis by sponging MiR-515-5p and upregulating SLC7A11.

KIF4A KIF4B

4.06e-06341235579738
Pubmed

Temporal and spatial localization of the dentin matrix proteins during dentin biomineralization.

DMP1 DSPP

4.06e-06341219001636
Pubmed

Human TAFII250 interacts with RAP74: implications for RNA polymerase II initiation.

GTF2F1 TAF1

4.06e-0634127590250
Pubmed

Tumor formation via loss of a molecular motor protein.

KIF4A KIF4B

4.06e-06341216890532
Pubmed

KIF4 mediates anterograde translocation and positioning of ribosomal constituents to axons.

KIF4A KIF4B

4.06e-06341219158085
Pubmed

Directed proteomic analysis of the human nucleolus.

BOP1 UTP3 P4HB HNRNPC DDX10

4.59e-0620841511790298
Pubmed

Proteomic and yeast 2-hybrid screens to identify PTEN binding partners.

TPR CAND1 NRDC HNRNPC EFTUD2

6.86e-0622641537839992
Pubmed

Investigation of osteocalcin, osteonectin, and dentin sialophosphoprotein in developing human teeth.

DMP1 DSPP

8.12e-06441211856645
Pubmed

Kinesin KIF4 regulates intracellular trafficking and stability of the human immunodeficiency virus type 1 Gag polyprotein.

KIF4A KIF4B

8.12e-06441218684836
Pubmed

Kif4 Is Essential for Mouse Oocyte Meiosis.

KIF4A KIF4B

8.12e-06441228125646
Pubmed

Functional analysis of the human TAFII250 N-terminal kinase domain.

GTF2F1 TAF1

8.12e-0644129660973
Pubmed

Rb inhibits the intrinsic kinase activity of TATA-binding protein-associated factor TAFII250.

GTF2F1 TAF1

8.12e-0644129858607
Pubmed

Interaction with general transcription factor IIF (TFIIF) is required for the suppression of activated transcription by RPB5-mediating protein (RMP).

GTF2F1 URI1

8.12e-06441212737519
Pubmed

Klf10 regulates odontoblast differentiation and mineralization via promoting expression of dentin matrix protein 1 and dentin sialophosphoprotein genes.

DMP1 DSPP

8.12e-06441226310138
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

TPR KIF4A BOP1 HUWE1 UBR5 P4HB DDX10

1.03e-0565341722586326
Pubmed

SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.

WRNIP1 CAND1 HUWE1 UBR5 P4HB EIF2B5 EFTUD2

1.07e-0565741736180527
Pubmed

Human Antiviral Protein IFIX Suppresses Viral Gene Expression during Herpes Simplex Virus 1 (HSV-1) Infection and Is Counteracted by Virus-induced Proteasomal Degradation.

WRNIP1 BOP1 HUWE1 UBR5 HDGFL2

1.14e-0525141528077445
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

ANKRD26 TPR KIF4A CAND1 AFTPH HDGFL2 DDX10 EFTUD2

1.14e-0593441833916271
Pubmed

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.

WRNIP1 BOP1 UTP3 HUWE1 UBR5 TSPYL2

1.22e-0544041634244565
Pubmed

Phenotypic changes in dentition of Runx2 homozygote-null mutant mice.

DMP1 DSPP

1.35e-05541214688224
Pubmed

The role of the SIBLING, Bone Sialoprotein in skeletal biology - Contribution of mouse experimental genetics.

DMP1 DSPP

1.35e-05541226763578
Pubmed

Activity-Based Probes for HECT E3 Ubiquitin Ligases.

HUWE1 UBR5

1.35e-05541228425671
Pubmed

A dynamic model for PC4 coactivator function in RNA polymerase II transcription.

GTF2F1 TAF1

1.35e-0554129482861
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

TPR KIF4A KIF4B STRN CAND1 HUWE1 UBR5 EFTUD2

1.43e-0596341828671696
Pubmed

Quantitative interactome proteomics identifies a proteostasis network for GABAA receptors.

CAND1 HUWE1 UBR5 P4HB

1.45e-0512541436030824
Pubmed

The MYO6 interactome reveals adaptor complexes coordinating early endosome and cytoskeletal dynamics.

WRNIP1 STRN P4HB HNRNPC

1.45e-0512541429467281
Pubmed

A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.

WRNIP1 BOP1 URI1 CAND1 HUWE1 NRDC UBR5 P4HB

1.55e-0597441828675297
Pubmed

BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.

BOP1 CAND1 HUWE1 SETSIP METAP2 HNRNPC CHAF1A DDX10 EFTUD2

1.84e-05131841930463901
Pubmed

Chromosomal domains and escape from X inactivation: comparative X inactivation analysis in mouse and human.

HUWE1 TSPYL2

2.03e-05641211003698
Pubmed

CHIP inhibits odontoblast differentiation through promoting DLX3 polyubiquitylation and degradation.

DMP1 DSPP

2.03e-05641237213079
Pubmed

Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.

URI1 CAND1 HUWE1 NRDC UBR5 SETSIP P4HB HNRNPC EFTUD2

2.03e-05133541929229926
Pubmed

A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.

WRNIP1 GTF2F1 URI1 AFTPH UBR5 METAP2 HNRNPC EIF2B5

2.44e-05103841826673895
Pubmed

Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.

WRNIP1 TPR KIF4A GTF2F1 HDGFL2 DDX10

2.69e-0550641630890647
Pubmed

HIV-1 Vpr induces cell cycle arrest and enhances viral gene expression by depleting CCDC137.

UTP3 HDGFL2 HNRNPC DDX10

2.82e-0514841432538781
Pubmed

MEPE Localization in the Craniofacial Complex and Function in Tooth Dentin Formation.

DMP1 DSPP

2.84e-05741226927967
Pubmed

Evolutionary conservation of human TATA-binding-polypeptide-associated factors TAFII31 and TAFII80 and interactions of TAFII80 with other TAFs and with general transcription factors.

GTF2F1 TAF1

2.84e-0574127667268
Pubmed

Kinesin family in murine central nervous system.

KIF4A KIF4B

2.84e-0574121447303
Pubmed

Identification of novel ERK2 substrates through use of an engineered kinase and ATP analogs.

TPR UBR5

2.84e-05741212594221
Pubmed

Genetic mapping in the mouse of Kif4, a gene encoding a kinesin-like motor protein.

KIF4A KIF4B

2.84e-0574129196009
Pubmed

FCP1, the RAP74-interacting subunit of a human protein phosphatase that dephosphorylates the carboxyl-terminal domain of RNA polymerase IIO.

GTF2F1 TAF1

3.78e-0584129765293
Pubmed

Mutation in SSUH2 Causes Autosomal-Dominant Dentin Dysplasia Type I.

DMP1 DSPP

3.78e-05841227680507
Pubmed

Expression, functional, and structural analysis of proteins critical for otoconia development.

DMP1 DSPP

3.78e-05841220803598
Pubmed

Optimized fragmentation schemes and data analysis strategies for proteome-wide cross-link identification.

KIF4B CAND1 UBR5 HDGFL2 HNRNPC CHAF1A

3.78e-0553841628524877
InteractionWDR5 interactions

TPR BOP1 GTF2F1 TAF1 CAND1 UBR5 P4HB HDGFL2 METAP2 HNRNPC CHAF1A EIF2B5 EFTUD2

1.51e-0711014113int:WDR5
InteractionRPS19 interactions

TPR BOP1 GTF2F1 CAND1 UTP3 HUWE1 METAP2 HNRNPC DDX10 EFTUD2

4.42e-076394110int:RPS19
InteractionPOLR1G interactions

BOP1 GTF2F1 URI1 TAF1 UTP3 HUWE1 BAZ2B CHAF1A DDX10

4.76e-07489419int:POLR1G
InteractionGNL1 interactions

GTF2F1 HUWE1 NRDC HNRNPC EFTUD2

1.17e-0692415int:GNL1
InteractionXRCC6 interactions

TPR KIF4A GTF2F1 TAF1 CAND1 UTP3 HUWE1 HDGFL2 CHAF1A DDX10 EFTUD2

1.65e-069284111int:XRCC6
InteractionACTL6A interactions

CAND1 HUWE1 UBR5 HDGFL2 METAP2 HNRNPC CHAF1A

1.72e-06289417int:ACTL6A
InteractionGTF2E2 interactions

TPR GTF2F1 UBR5 HDGFL2 CHAF1A EFTUD2

1.90e-06185416int:GTF2E2
InteractionZNF330 interactions

KIF4A GTF2F1 TAF1 CAND1 UTP3 HNRNPC CHAF1A DDX10

2.72e-06446418int:ZNF330
InteractionSNRNP40 interactions

WRNIP1 BOP1 GTF2F1 UTP3 UBR5 BAZ2B HDGFL2 HNRNPC EFTUD2

4.22e-06637419int:SNRNP40
InteractionRPL30 interactions

BOP1 CAND1 HUWE1 UBR5 METAP2 HNRNPC DDX10 EFTUD2

4.26e-06474418int:RPL30
InteractionBRCA1 interactions

WRNIP1 ANKRD26 TPR STRN GTF2F1 CAND1 HUWE1 UBR5 P4HB HNRNPC CHAF1A EFTUD2

4.48e-0612494112int:BRCA1
InteractionDDX23 interactions

BOP1 GTF2F1 TAF1 UTP3 UBR5 HDGFL2 DDX10 EFTUD2

4.68e-06480418int:DDX23
InteractionRPL31 interactions

BOP1 GTF2F1 TAF1 CAND1 UTP3 METAP2 HNRNPC DDX10 EFTUD2

7.15e-06680419int:RPL31
InteractionRPL13 interactions

BOP1 CAND1 UTP3 HUWE1 HDGFL2 METAP2 TSPYL2 DDX10 EFTUD2

9.03e-06700419int:RPL13
InteractionRPS24 interactions

BOP1 GTF2F1 CAND1 UTP3 HUWE1 METAP2 DDX10 EFTUD2

9.52e-06529418int:RPS24
InteractionH3C1 interactions

TPR KIF4A GTF2F1 TAF1 UTP3 HDGFL2 CHAF1A TSPYL2 DDX10 EFTUD2

9.61e-069014110int:H3C1
InteractionCTPS1 interactions

CAND1 HUWE1 UBR5 METAP2 CHAF1A EFTUD2

1.12e-05252416int:CTPS1
InteractionEIF3I interactions

HUWE1 UBR5 METAP2 CHAF1A EIF2B5 EFTUD2

1.28e-05258416int:EIF3I
InteractionRPL14 interactions

BOP1 GTF2F1 CAND1 UTP3 UBR5 METAP2 DDX10 EFTUD2

1.33e-05554418int:RPL14
InteractionPRKRA interactions

IFIH1 BOP1 CAND1 UTP3 HNRNPC TSPYL2 DDX10

1.45e-05400417int:PRKRA
InteractionCSNK2A1 interactions

BOP1 STRN GTF2F1 TAF1 SETSIP HDGFL2 HNRNPC EIF2B5 TSPYL2 EFTUD2

1.61e-059564110int:CSNK2A1
InteractionEIF2S1 interactions

STRN CAND1 HUWE1 P4HB METAP2 EFTUD2

1.88e-05276416int:EIF2S1
InteractionCIRBP interactions

TPR GTF2F1 CAND1 HUWE1 EFTUD2

1.99e-05164415int:CIRBP
InteractionEFTUD2 interactions

TPR KIF4A GTF2F1 CAND1 HUWE1 UBR5 P4HB HDGFL2 METAP2 HNRNPC CHAF1A EFTUD2

2.03e-0514494112int:EFTUD2
InteractionITGB3 interactions

TPR CAND1 HUWE1 P4HB PTPRZ1

2.36e-05170415int:ITGB3
InteractionSMC5 interactions

TPR KIF4A TAF1 UTP3 BAZ2B HDGFL2 HNRNPC CHAF1A DDX10 EFTUD2

2.38e-0510004110int:SMC5
InteractionEIF3K interactions

HUWE1 METAP2 CHAF1A EIF2B5 EFTUD2

2.43e-05171415int:EIF3K
InteractionRFC2 interactions

GTF2F1 CAND1 HUWE1 CHAF1A EFTUD2

2.64e-05174415int:RFC2
InteractionRPL22 interactions

BOP1 GTF2F1 CAND1 HUWE1 HDGFL2 METAP2 EFTUD2

2.67e-05440417int:RPL22
InteractionSRSF4 interactions

WRNIP1 CAND1 HUWE1 UBR5 HNRNPC DDX10

3.00e-05300416int:SRSF4
InteractionARRB2 interactions

BOP1 EIF2AK4 UBR5 P4HB HDGFL2 HNRNPC EFTUD2

3.26e-05454417int:ARRB2
InteractionSIRT6 interactions

WRNIP1 KIF4A BOP1 UTP3 HUWE1 UBR5 TSPYL2 EFTUD2

3.27e-05628418int:SIRT6
InteractionSAP18 interactions

TPR TAF1 HUWE1 UBR5 HNRNPC EFTUD2

3.29e-05305416int:SAP18
InteractionSET interactions

HUWE1 UBR5 SETSIP CHAF1A TSPYL2 EFTUD2

3.67e-05311416int:SET
InteractionSRSF5 interactions

TPR BOP1 CAND1 HUWE1 HNRNPC DDX10 EFTUD2

4.28e-05474417int:SRSF5
InteractionCDC5L interactions

WRNIP1 TPR KIF4A CAND1 HUWE1 ZBTB7C UBR5 HNRNPC EFTUD2

4.40e-05855419int:CDC5L
InteractionCHAF1A interactions

CAND1 HUWE1 NRDC UBR5 CHAF1A EFTUD2

4.46e-05322416int:CHAF1A
InteractionTSR1 interactions

CAND1 HDGFL2 HNRNPC CHAF1A DDX10 EFTUD2

4.46e-05322416int:TSR1
InteractionRPLP0 interactions

BOP1 CAND1 UTP3 HUWE1 METAP2 TSPYL2 DDX10 EFTUD2

4.66e-05660418int:RPLP0
InteractionPDIA6 interactions

CAND1 HUWE1 NRDC P4HB DMXL1 EFTUD2

4.86e-05327416int:PDIA6
InteractionRPS6 interactions

ERICH1 BOP1 CAND1 UTP3 P4HB METAP2 CHAF1A DDX10 EFTUD2

5.22e-05874419int:RPS6
InteractionH3C3 interactions

KIF4A BOP1 TAF1 BAZ2B HDGFL2 METAP2 CHAF1A

5.64e-05495417int:H3C3
InteractionGTF2A1 interactions

BOP1 GTF2F1 TAF1 HUWE1

5.85e-05104414int:GTF2A1
InteractionSF3A3 interactions

GTF2F1 CAND1 HUWE1 HNRNPC CHAF1A EFTUD2

6.03e-05340416int:SF3A3
InteractionRPL36 interactions

BOP1 CAND1 METAP2 HNRNPC TSPYL2 DDX10 EFTUD2

6.31e-05504417int:RPL36
InteractionPPP1CA interactions

EIF2AK4 URI1 HUWE1 UBR5 P4HB HNRNPC CHAF1A EFTUD2

6.77e-05696418int:PPP1CA
InteractionSRRM1 interactions

GTF2F1 EIF2AK4 CAND1 HUWE1 UBR5 EFTUD2

6.86e-05348416int:SRRM1
InteractionPOLR1E interactions

BOP1 GTF2F1 URI1 TAF1 UTP3 BAZ2B

7.08e-05350416int:POLR1E
InteractionPTN interactions

GTF2F1 UTP3 P4HB PTPRZ1

7.54e-05111414int:PTN
InteractionRANBP2 interactions

TPR TAF1 HUWE1 HNRNPC CHAF1A EFTUD2

8.39e-05361416int:RANBP2
InteractionCSNK2A2 interactions

BOP1 HUWE1 P4HB HDGFL2 HNRNPC EIF2B5 TSPYL2 EFTUD2

8.41e-05718418int:CSNK2A2
InteractionRPL15 interactions

GTF2F1 CAND1 HUWE1 METAP2 TSPYL2 DDX10 EFTUD2

8.65e-05530417int:RPL15
InteractionUSP37 interactions

WRNIP1 TAF1 HNRNPC EFTUD2

8.66e-05115414int:USP37
InteractionSMARCB1 interactions

GTF2F1 CAND1 UBR5 HNRNPC CHAF1A EFTUD2

8.78e-05364416int:SMARCB1
InteractionRPS16 interactions

CAND1 UTP3 HUWE1 METAP2 EIF2B5 TSPYL2 DDX10 EFTUD2

8.91e-05724418int:RPS16
InteractionDDA1 interactions

TAF1 CAND1 UTP3 HNRNPC CHAF1A EFTUD2

9.33e-05368416int:DDA1
InteractionSMU1 interactions

CAND1 HUWE1 UBR5 HNRNPC EFTUD2

9.34e-05227415int:SMU1
InteractionPIH1D1 interactions

URI1 CAND1 HUWE1 NRDC UBR5 METAP2 HNRNPC EFTUD2

9.53e-05731418int:PIH1D1
InteractionRPL8 interactions

CAND1 UTP3 HUWE1 UBR5 METAP2 DDX10 EFTUD2

9.61e-05539417int:RPL8
InteractionEED interactions

TPR KIF4A BOP1 CAND1 HUWE1 BAZ2B METAP2 HNRNPC DMXL1 DDX10 EFTUD2

1.05e-0414454111int:EED
InteractionCENPA interactions

KIF4A GTF2F1 TAF1 UTP3 HDGFL2 CHAF1A

1.06e-04377416int:CENPA
InteractionCOIL interactions

WRNIP1 ERICH1 GTF2F1 TAF1 CAND1 BAZ2B TSPYL2

1.12e-04552417int:COIL
InteractionTERF2IP interactions

WRNIP1 ERICH1 KIF4A GTF2F1 TAF1 CHAF1A DDX10

1.12e-04552417int:TERF2IP
InteractionNPM1 interactions

TPR BOP1 CAND1 HIVEP2 UTP3 HUWE1 HNRNPC CHAF1A DDX10 EFTUD2

1.12e-0412014110int:NPM1
InteractionH3-3A interactions

ERICH1 KIF4A TAF1 HDGFL2 METAP2 HNRNPC CHAF1A DDX10

1.13e-04749418int:H3-3A
InteractionSMARCC1 interactions

GTF2F1 CAND1 HDGFL2 HNRNPC CHAF1A EFTUD2

1.18e-04384416int:SMARCC1
InteractionHNRNPA2B1 interactions

TPR KIF4A CAND1 HUWE1 HDGFL2 HNRNPC TSPYL2 EFTUD2

1.18e-04754418int:HNRNPA2B1
InteractionPRC1 interactions

TPR KIF4A BOP1 KIF4B UTP3 P4HB BAZ2B HNRNPC EFTUD2

1.19e-04973419int:PRC1
InteractionTUBB4B interactions

TPR KIF4A CAND1 HUWE1 AFTPH HNRNPC EFTUD2

1.22e-04560417int:TUBB4B
InteractionRPL4 interactions

BOP1 CAND1 HUWE1 HDGFL2 METAP2 TSPYL2 DDX10 EFTUD2

1.29e-04764418int:RPL4
InteractionHECTD1 interactions

KIF4A BOP1 TAF1 CAND1 UTP3 HUWE1 EIF2B5 DDX10 EFTUD2

1.30e-04984419int:HECTD1
InteractionEIF3D interactions

CAND1 METAP2 CHAF1A EIF2B5 EFTUD2

1.31e-04244415int:EIF3D
InteractionEIF3L interactions

HUWE1 METAP2 CHAF1A EIF2B5 EFTUD2

1.31e-04244415int:EIF3L
InteractionSRSF1 interactions

CAND1 UTP3 HUWE1 UBR5 HNRNPC DDX10 EFTUD2

1.36e-04570417int:SRSF1
InteractionNOP56 interactions

BOP1 GTF2F1 CAND1 UTP3 P4HB DDX10 EFTUD2

1.36e-04570417int:NOP56
InteractionAR interactions

WRNIP1 TPR KIF4A GTF2F1 TAF1 CAND1 HUWE1 UBR5 EFTUD2

1.38e-04992419int:AR
InteractionSLX4 interactions

WRNIP1 KIF4A GTF2F1 CAND1 UBR5 BAZ2B EFTUD2

1.39e-04572417int:SLX4
InteractionZBTB7A interactions

TAF1 HUWE1 ZBTB7C UBR5

1.43e-04131414int:ZBTB7A
InteractionNHP2 interactions

CAND1 HUWE1 UBR5 EFTUD2

1.43e-04131414int:NHP2
InteractionDHX40 interactions

TAF1 UTP3 UBR5 HNRNPC DDX10

1.44e-04249415int:DHX40
InteractionH2BC8 interactions

KIF4A BOP1 GTF2F1 UTP3 HDGFL2 CHAF1A DDX10

1.45e-04576417int:H2BC8
InteractionPRPS2 interactions

GTF2F1 EIF2AK4 URI1 HUWE1 EFTUD2

1.55e-04253415int:PRPS2
InteractionRPL13A interactions

BOP1 GTF2F1 CAND1 HUWE1 METAP2 DDX10 EFTUD2

1.70e-04591417int:RPL13A
InteractionSUMO2 interactions

TPR KIF4A TAF1 HUWE1 P4HB CHAF1A EFTUD2

1.70e-04591417int:SUMO2
InteractionNCL interactions

GTF2F1 EIF2AK4 CAND1 HUWE1 PTPRZ1 HDGFL2 METAP2 EFTUD2

1.75e-04798418int:NCL
InteractionAPEX1 interactions

GTF2F1 UTP3 P4HB HDGFL2 METAP2 HNRNPC CHAF1A EIF2B5 DDX10 EFTUD2

1.78e-0412714110int:APEX1
InteractionSMARCA5 interactions

TPR KIF4A HUWE1 HNRNPC CHAF1A EFTUD2

1.80e-04415416int:SMARCA5
InteractionGTF2F2 interactions

GTF2F1 URI1 UBR5 EFTUD2

2.01e-04143414int:GTF2F2
InteractionEEF1B2 interactions

TPR GTF2F1 CAND1 HUWE1 EFTUD2

2.03e-04268415int:EEF1B2
InteractionGTF2E1 interactions

KIF4A GTF2F1 TAF1 EFTUD2

2.06e-04144414int:GTF2E1
InteractionRPL7P32 interactions

CAND1 HUWE1

2.20e-0411412int:RPL7P32
InteractionCHAMP1 interactions

BOP1 HDGFL2 CHAF1A EFTUD2

2.29e-04148414int:CHAMP1
InteractionNUP43 interactions

WRNIP1 BOP1 UTP3 UBR5 BAZ2B EIF2B5 TSPYL2

2.40e-04625417int:NUP43
InteractionCSNK2B interactions

ERICH1 UTP3 BAZ2B HDGFL2 TSPYL2 DDX10 EFTUD2

2.40e-04625417int:CSNK2B
InteractionGABRA1 interactions

CAND1 HUWE1 UBR5 P4HB

2.54e-04152414int:GABRA1
InteractionRPL6 interactions

TPR GTF2F1 CAND1 HUWE1 METAP2 HNRNPC EFTUD2

2.69e-04637417int:RPL6
InteractionSNU13 interactions

TPR BOP1 CAND1 HNRNPC EFTUD2

2.70e-04285415int:SNU13
InteractionSMARCE1 interactions

CAND1 HDGFL2 HNRNPC CHAF1A EFTUD2

2.79e-04287415int:SMARCE1
InteractionYAP1 interactions

TPR KIF4A TAF1 CAND1 HUWE1 P4HB HNRNPC TMEM151B TSPYL2

2.89e-041095419int:YAP1
InteractionSRSF2 interactions

TPR CAND1 HUWE1 UBR5 EFTUD2

2.92e-04290415int:SRSF2
Cytoband19q12

URI1 PLEKHF1

1.46e-042041219q12
CytobandEnsembl 112 genes in cytogenetic band chr19q12

URI1 PLEKHF1

3.33e-0430412chr19q12
CytobandXq13.1

KIF4A TAF1

8.55e-0448412Xq13.1
Cytoband19p13.3

GTF2F1 HDGFL2 CHAF1A

1.25e-0323741319p13.3
CytobandEnsembl 112 genes in cytogenetic band chr4q22

DMP1 DSPP

2.02e-0374412chr4q22
CytobandEnsembl 112 genes in cytogenetic band chr2q24

IFIH1 BAZ2B

5.80e-03127412chr2q24
CytobandEnsembl 112 genes in cytogenetic band chrXq13

KIF4A TAF1

9.60e-03165412chrXq13
GeneFamilySIBLING family

DMP1 DSPP

2.14e-0552721279
GeneFamilyKinesins|Pleckstrin homology domain containing

KIF4A KIF4B

2.13e-0346272622
CoexpressionCAIRO_HEPATOBLASTOMA_CLASSES_UP

KIF4A BOP1 GTF2F1 HUWE1 P4HB HNRNPC CHAF1A DDX10

3.36e-06612408M4772
CoexpressionGSE6674_CPG_VS_PL2_3_STIM_BCELL_DN

WRNIP1 TPR CAND1 NRDC UBR5

1.30e-05200405M6938
CoexpressionPUJANA_ATM_PCC_NETWORK

ERICH1 ANKRD26 STRN TAF1 UTP3 METAP2 HNRNPC CHAF1A EIF2B5 DDX10

3.43e-0513944010M9585
ComputationalNeighborhood of XPC

TPR URI1 HUWE1 UBR5

2.30e-0561304MORF_XPC
Diseaseatrophic macular degeneration

ERICH1 HNRNPC

5.01e-0425392EFO_1001492
Diseaseovarian neoplasm

BNC2 URI1 PLEKHF1

7.43e-04134393C0919267
DiseaseMalignant neoplasm of ovary

BNC2 URI1 PLEKHF1

7.92e-04137393C1140680
Diseasemajor depressive disorder

BNC2 HIVEP2 NRDC

1.13e-03155393MONDO_0002009
Diseaseurate measurement, bone density

STRN EIF2AK4 BAZ2B HNRNPC DDX10

1.28e-03619395EFO_0003923, EFO_0004531
Diseaseosteoarthritis, knee, body mass index

BNC2 HNRNPC

1.35e-0341392EFO_0004340, EFO_0004616

Protein segments in the cluster

PeptideGeneStartEntry
SEDDDEGDEEGEDGA

BOP1

71

Q14137
DSGEEDGADASEEDD

ERICH1

316

Q86X53
SDDEDDDEDEHGGVF

EIF2AK4

731

Q9P2K8
DEFDDEDDDPNDGGA

BNC2

651

Q6ZN30
LDNGAEDDDDDEFGE

AFTPH

16

Q6ULP2
DDDDDDSDDQGDEDD

BAZ2B

1301

Q9UIF8
ADEDEDEGSGDDEDE

DSPP

251

Q9NZW4
DGATDDAEDDDDDDG

ANKRD26

566

Q9UPS8
SEGDDDDDMGEDEDE

CHAF1A

616

Q13111
LGSDDDDNDDDDDVL

DMXL1

2456

Q9Y485
EEGEDDRDSANGEDD

HNRNPC

291

P07910
RDEDDEDGDGDGDGA

METAP2

81

P50579
EDEDENAMDADGGDD

CAND1

316

Q86VP6
DGGDDDDQGSDDEYS

CAND1

326

Q86VP6
AEEDEDDGEFSDDSG

EIF2B5

456

Q13144
DEDDDDDSDEPGSRG

NANOS1

106

Q8WY41
DGAGDDDDLEDLEEA

P4HB

476

P07237
GEDGDTDDDGDDDDD

PTPRZ1

1416

P23471
TDDDGDDDDDDRGSD

PTPRZ1

1421

P23471
DKDDDEDDSGDDTFG

DMP1

101

Q13316
GEEGDEDDDDDGSEM

HUWE1

2451

Q7Z6Z7
ADGSDADEDDEDRGV

HDGFL2

111

Q7Z4V5
DEGGDDEYCDGDEDE

IFIH1

646

Q9BYX4
EDGDGDDDEGDDEEW

KIF4A

1056

O95239
EDGDGDGDSDEGDDE

KIF4B

1056

Q2VIQ3
DDDDDDDDGFDPSTL

DDX10

781

Q13206
DMDDEDDEDGGNAGE

UTP3

86

Q9NQZ2
DDDSDEDKEGSRDGD

PLEKHF1

246

Q96S99
KGSDDEAFEDSDDGD

GTF2F1

251

P35269
AADFSDEDEDDDVDG

STRN

241

O43815
DDDDDDNIDDDDGDN

URI1

306

O94763
ASMGDDEDDDEEEAG

TMEM151B

511

Q8IW70
GEDDEEDAGSDEEGD

TAF1

1721

P21675
EEGGEDDDDDDDDGD

SETSIP

251

P0DME0
DEASDDEDNDGNEGD

TSPYL2

566

Q9H2G4
DDDDDEDDTGMGDEG

TPR

1971

P12270
GFDDEDEFDDEHDDD

NRDC

171

O43847
DGEGDVAGDDDDDDD

SMAP

111

O00193
EDDDEDEGDDDDGGD

SPOCK3

416

Q9BQ16
DEGDDDDGGDDHDVY

SPOCK3

421

Q9BQ16
DGDGDGDADADGEDD

WRNIP1

171

Q96S55
GDGGEEDDKEDDDDD

ZBTB7C

131

A1YPR0
MDDDDDDDDVGDHDD

EFTUD2

36

Q15029
EESDGEDGDDNDDDD

HIVEP2

1901

P31629
NDDDDEDEDDFDDQG

HIVEP2

1911

P31629
RDDEDGDDGDDTASE

UBR5

226

O95071