Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	poly-N-acetyllactosamine biosynthetic process	B3GNT9 B4GALT5	8.87e-05	9	33	2	GO:0030311
GeneOntologyBiologicalProcess	regulation of collagen fibril organization	COLGALT1 AEBP1	8.87e-05	9	33	2	GO:1904026
GeneOntologyBiologicalProcess	poly-N-acetyllactosamine metabolic process	B3GNT9 B4GALT5	1.11e-04	10	33	2	GO:0030309
Domain	PBC	PBX4 PBX3	1.81e-05	4	33	2	PF03792
Domain	PBX	PBX4 PBX3	1.81e-05	4	33	2	IPR005542
Domain	-	COLGALT1 B4GALT5	8.99e-03	81	33	2	3.90.550.10
Domain	Nucleotide-diphossugar_trans	COLGALT1 B4GALT5	1.05e-02	88	33	2	IPR029044
Pubmed	hnRNP L regulates the tumorigenic capacity of lung cancer xenografts in mice via caspase-9 pre-mRNA processing.	CASP9 HNRNPL	9.84e-07	2	35	2	20972334
Pubmed	hnRNP U enhances caspase-9 splicing and is modulated by AKT-dependent phosphorylation of hnRNP L.	CASP9 HNRNPL	2.95e-06	3	35	2	23396972
Pubmed	New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.	ASPM PEX16 EGFR R3HDM4 EIF4A3 HNRNPL	6.23e-06	462	35	6	31138677
Pubmed	Pbx4, a new Pbx family member on mouse chromosome 8, is expressed during spermatogenesis.	PBX4 PBX3	9.82e-06	5	35	2	11335119
Pubmed	Transcription factor PBX4 regulates limb development and haematopoiesis in mice.	PBX4 PBX3	9.82e-06	5	35	2	38230761
Pubmed	Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck.	PKN2 EGFR	2.74e-05	8	35	2	10026169
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	ASPM SLTM TOR4A PKN2 COLGALT1 EIF4A3 HNRNPL RPL19	4.73e-05	1353	35	8	29467282
Pubmed	Hypomorphic mutation of the TALE gene Prep1 (pKnox1) causes a major reduction of Pbx and Meis proteins and a pleiotropic embryonic phenotype.	PBX4 PBX3	7.62e-05	13	35	2	16847320
Pubmed	Proteomic analysis identifies transcriptional cofactors and homeobox transcription factors as TBX18 binding proteins.	PBX4 PBX3	1.02e-04	15	35	2	30071041
Pubmed	Interactome analysis of the human Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 (hMTr1) protein.	EIF4A3 HNRNPL RPL19	3.65e-04	138	35	3	30320910
Pubmed	Methylation of the DNA/RNA-binding protein Kin17 by METTL22 affects its association with chromatin.	HNRNPL RPL19	4.20e-04	30	35	2	24140279
Pubmed	Targeted ubiquitination and degradation of G-protein-coupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex.	TOR4A FRYL EIF4A3	5.21e-04	156	35	3	22952844
Pubmed	The cellular EJC interactome reveals higher-order mRNP structure and an EJC-SR protein nexus.	EIF4A3 HNRNPL RPL19	6.58e-04	169	35	3	23084401
Pubmed	Beads-free protein immunoprecipitation for a mass spectrometry-based interactome and posttranslational modifications analysis.	EIF4A3 HNRNPL RPL19	6.92e-04	172	35	3	26336360
Pubmed	A genome-scale protein interaction profile of Drosophila p53 uncovers additional nodes of the human p53 network.	ASPM TTLL5	7.49e-04	40	35	2	20308539
Pubmed	Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma.	PBX4 TOR4A EIF4A3 HNRNPL RPL19	7.84e-04	732	35	5	34732716
Pubmed	Delineating the HMGB1 and HMGB2 interactome in prostate and ovary epithelial cells and its relationship with cancer.	SLTM EIF4A3 RPL19	8.96e-04	188	35	3	29721183
Pubmed	Hepatitis C virus enters liver cells using the CD81 receptor complex proteins calpain-5 and CBLB.	EGFR C2orf72	9.06e-04	44	35	2	30024968
Pubmed	Targeted and Interactome Proteomics Revealed the Role of PHD2 in Regulating BRD4 Proline Hydroxylation.	AARS2 EIF4A3 HNRNPL RPL19	9.78e-04	441	35	4	31239290
Pubmed	Defining the membrane proteome of NK cells.	PEX16 COLGALT1 LRP10 EIF4A3 HNRNPL RPL19	9.98e-04	1168	35	6	19946888
Interaction	ZNHIT3 interactions	COLGALT1 PBX3 EGFR FCMR	1.47e-06	50	34	4	int:ZNHIT3
GeneFamily	TALE class homeoboxes and pseudogenes	PBX4 PBX3	4.94e-04	26	23	2	526
Drug	carboplatin	IL11 HMGN2P46 CASP9 TOP1MT EGFR TTLL5	4.58e-08	131	35	6	CID000038904
Drug	Flurandrenolide [1524-88-5]; Down 200; 9.2uM; MCF7; HT_HG-U133A	PEX16 CASP9 DOCK6 TTLL5 FCMR	1.13e-05	194	35	5	6039_DN
Drug	Acetopromazine maleate salt [3598-37-6]; Up 200; 9uM; MCF7; HT_HG-U133A	PEX16 IL11 CACNA1G AEBP1 FCMR	1.18e-05	196	35	5	6832_UP
Drug	Stachydrine hydrochloride; Up 200; 22.2uM; MCF7; HT_HG-U133A	IL11 EGFR TTLL5 CHST8 FCMR	1.21e-05	197	35	5	2743_UP
Drug	LY 294002; Up 200; 0.1uM; MCF7; HT_HG-U133A	IL11 DOCK6 TTLL5 CHST8 FCMR	1.21e-05	197	35	5	1641_UP
Drug	Kanamycin A sulfate [25389-94-0]; Up 200; 6.8uM; MCF7; HT_HG-U133A	CACNA1G PKN2 EGFR AEBP1 FCMR	1.27e-05	199	35	5	5686_UP
Drug	Papaverine hydrochloride [61-25-6]; Up 200; 10.6uM; MCF7; HT_HG-U133A	IL11 CACNA1G EGFR TTLL5 CHST8	1.27e-05	199	35	5	2747_UP
Drug	Ytterbium	CASP9 CACNA1G	2.29e-05	5	35	2	ctd:D015018
Drug	Gold Compounds	CASP9 EGFR	4.80e-05	7	35	2	ctd:D017612
Disease	corpus collosum mid-posterior volume measurement	IL11 EGFR	3.80e-04	25	34	2	EFO_0010300
Disease	Anasarca	IL11 CASP9	4.12e-04	26	34	2	C0151603
Disease	Edema	IL11 CASP9	4.12e-04	26	34	2	C0013604
Disease	Polyarthritis, Juvenile, Rheumatoid Factor Positive	TTLL5 B4GALT5 GP1BB	4.63e-04	131	34	3	C4704862
Disease	Polyarthritis, Juvenile, Rheumatoid Factor Negative	TTLL5 B4GALT5 GP1BB	4.63e-04	131	34	3	C4552091
Disease	Juvenile arthritis	TTLL5 B4GALT5 GP1BB	4.63e-04	131	34	3	C3495559
Disease	Juvenile psoriatic arthritis	TTLL5 B4GALT5 GP1BB	4.63e-04	131	34	3	C3714758
Disease	Juvenile-Onset Still Disease	TTLL5 B4GALT5 GP1BB	5.05e-04	135	34	3	C0087031
Disease	stomach cancer (is_marker_for)	ASPM CASP9 DOCK6	5.85e-04	142	34	3	DOID:10534 (is_marker_for)
Disease	microcephaly (implicated_via_orthology)	ASPM AARS2	6.25e-04	32	34	2	DOID:10907 (implicated_via_orthology)
Disease	Parkinsonism (biomarker_via_orthology)	CASP9 EGFR	7.06e-04	34	34	2	DOID:0080855 (biomarker_via_orthology)
Disease	Craniofacial Abnormalities	PBX4 EGFR GP1BB	7.69e-04	156	34	3	C0376634
Disease	white matter microstructure measurement	IL11 PKN2 PBX3 EGFR	1.02e-03	390	34	4	EFO_0005674
Disease	high grade glioma (is_marker_for)	ASPM EGFR	1.08e-03	42	34	2	DOID:3070 (is_marker_for)
Disease	diabetic retinopathy (is_marker_for)	CASP9 EGFR	1.78e-03	54	34	2	DOID:8947 (is_marker_for)
Disease	oral squamous cell carcinoma (is_marker_for)	EGFR DOCK6	2.41e-03	63	34	2	DOID:0050866 (is_marker_for)
Disease	esophagus squamous cell carcinoma (is_marker_for)	PBX3 EGFR	3.30e-03	74	34	2	DOID:3748 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
LAAREPRRRLREMLR	C2orf72	116	A6NCS6
RRLQHRLRLRAQMRL	AEBP1	1021	Q8IUX7
RLRLRAQMRLRRLNA	AEBP1	1026	Q8IUX7
MRARRGLLRLPRRSL	B4GALT5	1	O43286
RRFRTLMMRRRFLSL	ASPM	2271	Q8IZT6
RLTELSLRRRQMLLL	ASTE1	431	Q2TB18
RISRRLRAVLKRSRI	R3HDM4	171	Q96D70
MILRSRFLDARRKRR	PBX3	226	P40426
HLRRSLVRRRMLEAL	C19orf81	176	C9J6K1
RRQRGRLMRRLVRRL	LRP10	546	Q7Z4F1
RLMRRLVRRLRRWGL	LRP10	551	Q7Z4F1
IRRRSLRTRAIKMLV	EIF4A3	171	P38919
LLCRLRRLRARARAR	GP1BB	171	P13224
RYLQRRREKLMLARR	HMGN2P46	121	Q86SG4
ARLDRLLRRLQLLMS	IL11	131	P20809
RFKRRRVRRRRMETI	PCMTD2	276	Q9NV79
RPENMKRRRRRDILR	FRYL	966	O94915
MARRSRHRLLLLLLR	JAM2	1	P57087
MTLRSRLLDARRKRR	PBX4	201	Q9BYU1
LFMRRRHIVRKRTLR	EGFR	666	P00533
LADMRRPSSLLRRLR	DOCK6	476	Q96HP0
MLRVLRLLRTLRPLR	CACNA1G	1376	O43497
MDEADRRLLRRCRLR	CASP9	1	P55211
MSRRLLPRAEKRRRR	HNRNPL	1	P14866
INLRRRQDRRERMLR	COLGALT1	346	Q8NBJ5
LLRMGMRLQLLRDRR	FAM27D1	6	Q5T7N8
LTRRERRELRRRTIL	PEX16	266	Q9Y5Y5
MRRMRILRRLLRRYR	RPL19	96	P84098
RFERLRRAMELRRRR	SLTM	621	Q9NWH9
SIMRRLLRRNPERRL	PKN2	886	Q16513
RRILRRAVRFSMEIL	AARS2	351	Q5JTZ9
MRRRLRLRRDALLTL	B3GNT9	1	Q6UX72
RGTRLRLRQRRRRLL	CHST8	101	Q9H2A9
LLARLLKRRRRSTLM	NDUFV1-DT	26	Q8NBR9
ALSRRARRLAVRMRA	FCMR	281	O60667
MRVVRLLRLRAALTL	TOP1MT	1	Q969P6
RLRRRVCVLRKRRLL	TOR4A	31	Q9NXH8
VRKRRRRSSRLRAMR	TTLL5	551	Q6EMB2
RMVLPSRRLALLERR	TTLL5	731	Q6EMB2