Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionalpha-tocopherol omega-hydroxylase activity

CYP4F2 CYP4F8

3.15e-055362GO:0052871
GeneOntologyMolecularFunctionleukotriene-B4 20-monooxygenase activity

CYP4F2 CYP4F8

6.60e-057362GO:0050051
GeneOntologyMolecularFunctionalkane 1-monooxygenase activity

CYP4F2 CYP4F8

6.60e-057362GO:0018685
GeneOntologyMolecularFunctionarachidonate omega-hydroxylase activity

CYP4F2 CYP4F8

1.41e-0410362GO:0052869
GeneOntologyMolecularFunctionfatty acid omega-hydroxylase activity

CYP4F2 CYP4F8

1.41e-0410362GO:0120250
GeneOntologyMolecularFunctionlong-chain fatty acid omega-hydroxylase activity

CYP4F2 CYP4F8

1.41e-0410362GO:0102033
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen

CYP4F2 CYP4F8

2.43e-0413362GO:0016713
GeneOntologyMolecularFunctionarachidonate binding

CYP4F2 CYP4F8

3.27e-0415362GO:0050544
GeneOntologyMolecularFunctionicosanoid binding

CYP4F2 CYP4F8

3.73e-0416362GO:0050542
GeneOntologyMolecularFunctionicosatetraenoic acid binding

CYP4F2 CYP4F8

3.73e-0416362GO:0050543
GeneOntologyMolecularFunctionexonuclease activity

PNLDC1 REXO1L1P REXO1

6.05e-0492363GO:0004527
GeneOntologyMolecularFunctionarachidonate epoxygenase activity

CYP4F2 CYP4F8

8.51e-0424362GO:0008392
GeneOntologyMolecularFunctionmonocarboxylic acid binding

CYP4F2 CYP4F8 IGF2R

9.39e-04107363GO:0033293
GeneOntologyMolecularFunctionarachidonate monooxygenase activity

CYP4F2 CYP4F8

1.08e-0327362GO:0008391
GeneOntologyMolecularFunctionlong-chain fatty acid binding

CYP4F2 CYP4F8

1.16e-0328362GO:0036041
GeneOntologyMolecularFunctionaromatase activity

CYP4F2 CYP4F8

1.81e-0335362GO:0070330
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

CYP4F2 CYP4F8

2.36e-0340362GO:0016709
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

CYP4F2 CYP4F8

3.52e-0349362GO:0016712
GeneOntologyBiologicalProcessleukotriene B4 catabolic process

CYP4F2 CYP4F8

3.94e-056342GO:0036101
GeneOntologyBiologicalProcessleukotriene B4 metabolic process

CYP4F2 CYP4F8

5.51e-057342GO:0036102
GeneOntologyBiologicalProcessleukotriene catabolic process

CYP4F2 CYP4F8

7.34e-058342GO:0036100
GeneOntologyBiologicalProcessicosanoid catabolic process

CYP4F2 CYP4F8

1.44e-0411342GO:1901523
GeneOntologyBiologicalProcessneuronal action potential

MTNR1B CACNA1H P2RX7

1.52e-0463343GO:0019228
GeneOntologyBiologicalProcesslong-chain fatty acid catabolic process

CYP4F2 CYP4F8

1.72e-0412342GO:0042758
GeneOntologyBiologicalProcessomega-hydroxylase P450 pathway

CYP4F2 CYP4F8

2.37e-0414342GO:0097267
DomainDUF4704

NBEA NBEAL1

3.21e-055342PF15787
DomainDUF4704

NBEA NBEAL1

3.21e-055342IPR031570
DomainPH_BEACH

NBEA NBEAL1

4.80e-056342PF14844
DomainSET

KMT2C SMYD5 PRDM1

5.60e-0541343PF00856
DomainSET

KMT2C SMYD5 PRDM1

7.93e-0546343SM00317
DomainPH-BEACH_dom

NBEA NBEAL1

8.95e-058342IPR023362
DomainPH_BEACH

NBEA NBEAL1

8.95e-058342PS51783
Domain-

NBEA NBEAL1

8.95e-0583422.30.29.40
DomainSET_dom

KMT2C SMYD5 PRDM1

1.02e-0450343IPR001214
DomainSET

KMT2C SMYD5 PRDM1

1.02e-0450343PS50280
DomainBeach

NBEA NBEAL1

1.15e-049342PF02138
Domain-

NBEA NBEAL1

1.15e-0493421.10.1540.10
DomainBEACH_dom

NBEA NBEAL1

1.15e-049342IPR000409
DomainBeach

NBEA NBEAL1

1.15e-049342SM01026
DomainBEACH

NBEA NBEAL1

1.15e-049342PS50197
DomainRNaseH-like_dom

PNLDC1 REXO1L1P REXO1

2.66e-0469343IPR012337
DomainEXOIII

REXO1L1P REXO1

2.89e-0414342SM00479
DomainExonuclease_RNaseT/DNA_pol3

REXO1L1P REXO1

2.89e-0414342IPR013520
DomainRNase_T

REXO1L1P REXO1

2.89e-0414342PF00929
DomainCyt_P450_E_grp-I

CYP4F2 CYP4F8

3.03e-0345342IPR002401
Domain-

PNLDC1 REXO1

3.30e-03473423.30.420.10
DomainCyt_P450_CS

CYP4F2 CYP4F8

4.18e-0353342IPR017972
DomainCYTOCHROME_P450

CYP4F2 CYP4F8

4.82e-0357342PS00086
Domain-

CYP4F2 CYP4F8

4.99e-03583421.10.630.10
Domainp450

CYP4F2 CYP4F8

4.99e-0358342PF00067
DomainCyt_P450

CYP4F2 CYP4F8

5.33e-0360342IPR001128
DomainPH_dom-like

NBEA NBEAL1 PLCH2 ADAP2

7.20e-03426344IPR011993
DomainConA-like_dom

NBEA RNF123 NBEAL1

7.28e-03219343IPR013320
Domain-

NBEA NBEAL1

1.29e-02953422.60.120.200
DomainWD_REPEATS_1

NBAS NBEA NBEAL1

1.39e-02278343PS00678
DomainWD_REPEATS_2

NBAS NBEA NBEAL1

1.40e-02279343PS50082
DomainWD_REPEATS_REGION

NBAS NBEA NBEAL1

1.40e-02279343PS50294
PathwayREACTOME_EICOSANOIDS

CYP4F2 CYP4F8

1.97e-0412252MM14845
PathwayREACTOME_EICOSANOIDS

CYP4F2 CYP4F8

1.97e-0412252M27129
PathwayWP_EICOSANOID_METABOLISM_VIA_CYTOCHROME_P450_MONOOXYGENASES

CYP4F2 CYP4F8

2.71e-0414252MM15842
PathwayREACTOME_FATTY_ACIDS

CYP4F2 CYP4F8

3.13e-0415252M27126
PathwayREACTOME_MISCELLANEOUS_SUBSTRATES

CYP4F2 CYP4F8

4.54e-0418252MM14843
PathwayREACTOME_FATTY_ACIDS

CYP4F2 CYP4F8

4.54e-0418252MM14841
PathwayREACTOME_SYNTHESIS_OF_LEUKOTRIENES_LT_AND_EOXINS_EX

CYP4F2 CYP4F8

6.21e-0421252M27137
PathwayREACTOME_SYNTHESIS_OF_LEUKOTRIENES_LT_AND_EOXINS_EX

CYP4F2 CYP4F8

8.83e-0425252MM14858
PathwayWP_SPHINGOLIPID_METABOLISM_OVERVIEW

GBA2 SPTLC2

1.03e-0327252M39863
PathwayWP_SPHINGOLIPID_PATHWAY

GBA2 SPTLC2

1.27e-0330252M39501
PathwayWP_EICOSANOID_METABOLISM_VIA_LIPOXYGENASES_LOX

CYP4F2 CYP4F8

1.54e-0333252MM15963
PathwayWP_EICOSANOID_METABOLISM_VIA_CYCLOOXYGENASES_COX

CYP4F2 CYP4F8

1.54e-0333252MM15918
PathwayREACTOME_NCAM1_INTERACTIONS

CACNA1H NCAN

2.49e-0342252M7169
Pubmed

Disruption of mouse cytochrome p450 4f14 (Cyp4f14 gene) causes severe perturbations in vitamin E metabolism.

CYP4F2 CYP4F8

6.60e-06437222665481
Pubmed

Expression and catalytic activity of mouse leukotriene B4 omega-hydroxylase, CYP4F14.

CYP4F2 CYP4F8

6.60e-06437211185557
Pubmed

Disruption of P450-mediated vitamin E hydroxylase activities alters vitamin E status in tocopherol supplemented mice and reveals extra-hepatic vitamin E metabolism.

CYP4F2 CYP4F8

1.10e-05537222969154
Pubmed

Cytochrome P4504f, a potential therapeutic target limiting neuroinflammation.

CYP4F2 CYP4F8

1.10e-05537221466787
Pubmed

The cytochrome P450 4 (CYP4) family.

CYP4F2 CYP4F8

1.65e-0563729068972
Pubmed

Role of ω-hydroxylase in adenosine-mediated aortic response through MAP kinase using A2A-receptor knockout mice.

CYP4F2 CYP4F8

2.30e-05737222160543
Pubmed

Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16.

RHBDL1 HS3ST6 CACNA1H

6.82e-057437311157797
Pubmed

AMPK Interactome Reveals New Function in Non-homologous End Joining DNA Repair.

SPTLC2 AJM1 PRDM1

2.93e-0412137331900314
Pubmed

Transcription factor Ctip2 controls epidermal lipid metabolism and regulates expression of genes involved in sphingolipid biosynthesis during skin development.

GBA2 SPTLC2

3.80e-042737223096701
Pubmed

A Single Adaptable Cochaperone-Scaffold Complex Delivers Nascent Iron-Sulfur Clusters to Mammalian Respiratory Chain Complexes I-III.

NBAS IGF2R SPTLC2 OGFR COQ8B

7.61e-0468637528380382
Pubmed

The interactome of metabolic enzyme carbonic anhydrase IX reveals novel roles in tumor cell migration and invadopodia/MMP14-mediated invasion.

NBAS IGF2R SPTLC2

8.72e-0417637328692057
Pubmed

Rab11-FIP1 and Rab11-FIP5 Regulate pIgR/pIgA Transcytosis through TRIM21-Mediated Polyubiquitination.

KMT2C NBEA

8.80e-044137234638806
Pubmed

Comparative expression profiling of 40 mouse cytochrome P450 genes in embryonic and adult tissues.

CYP4F2 CYP4F8

1.01e-034437212745259
CytobandEnsembl 112 genes in cytogenetic band chr19p13

CYP4F2 CYP4F8 REXO1 NCAN KLHL26

4.28e-04797375chr19p13
Cytoband16p13.3

RHBDL1 HS3ST6 CACNA1H

1.01e-0324437316p13.3
GeneFamilyWD repeat domain containing|BEACH domain containing

NBEA NBEAL1

6.57e-0592521230
GeneFamilyCytochrome P450 family 4

CYP4F2 CYP4F8

1.12e-03362521003
ToppCell18-Distal-Epithelial-Basal_cell|Distal / Age, Tissue, Lineage and Cell class

RHBDL1 SMYD5 DNAJC13 PLCH2

8.83e-06158374183f445967e09e871c93d8e94781ed9fec894169
ToppCelldroplet-Marrow-BM-30m-Lymphocytic-nan|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NBEA CACNA1H NCAN PRDM1

1.51e-05181374cd46eba2e03fd15d8de8e875793ae2f51fa98b3b
ToppCelldroplet-Marrow-BM-30m-Lymphocytic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NBEA CACNA1H NCAN PRDM1

1.51e-05181374c7d12c7de227c9433ec2303b8929e957b833f59b
ToppCelldroplet-Marrow-BM-30m-Lymphocytic-late_pro-B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NBEA CACNA1H NCAN PRDM1

1.61e-051843741e54fd372c6e6a298f427b807c14cc49aaaffe80
Diseasevery low density lipoprotein cholesterol measurement, lipid measurement

CD300LG IGF2R FGFBP3 NCAN

8.08e-05220314EFO_0004529, EFO_0008317
Diseasetriglyceride measurement, very low density lipoprotein cholesterol measurement

CD300LG IGF2R FGFBP3 NCAN

8.66e-05224314EFO_0004530, EFO_0008317
Diseasevery low density lipoprotein cholesterol measurement, phospholipid measurement

CD300LG IGF2R FGFBP3 NCAN

9.43e-05229314EFO_0004639, EFO_0008317
Diseasevery low density lipoprotein cholesterol measurement

CD300LG IGF2R FGFBP3 NCAN

1.54e-04260314EFO_0008317
Diseaseobsolete_red blood cell distribution width

CD300LG RNF123 DNAJC13 GBA2 SPTLC2 REXO1 HCAR1

4.07e-041347317EFO_0005192
Diseaselow density lipoprotein cholesterol measurement, cholesteryl esters:total lipids ratio

CD300LG IGF2R NCAN

5.52e-04153313EFO_0004611, EFO_0020944
Diseasecholesteryl esters to total lipids in medium LDL percentage

CD300LG IGF2R

6.95e-0437312EFO_0022252
Diseasetriglyceride measurement, low density lipoprotein cholesterol measurement

CD300LG IGF2R FGFBP3

7.00e-04166313EFO_0004530, EFO_0004611
Diseasefatty acid measurement

CD300LG PNLDC1 IGF2R NCAN

1.08e-03436314EFO_0005110
Diseaselung adenocarcinoma (is_implicated_in)

KMT2C PRDM1

1.22e-0349312DOID:3910 (is_implicated_in)
Diseasefree cholesterol measurement, very low density lipoprotein cholesterol measurement

CD300LG IGF2R NCAN

1.48e-03215313EFO_0008317, EFO_0008591
Diseasevery low density lipoprotein cholesterol measurement, cholesterol:total lipids ratio

CD300LG IGF2R HCAR1

1.62e-03222313EFO_0008317, EFO_0020943
Diseasetotal cholesterol measurement, very low density lipoprotein cholesterol measurement

CD300LG IGF2R NCAN

1.66e-03224313EFO_0004574, EFO_0008317
Diseasecholesteryl ester measurement, very low density lipoprotein cholesterol measurement

CD300LG IGF2R NCAN

1.68e-03225313EFO_0008317, EFO_0010351
Diseasetriglycerides:total lipids ratio, very low density lipoprotein cholesterol measurement

CD300LG IGF2R HCAR1

1.68e-03225313EFO_0008317, EFO_0020947
Diseasetriglycerides in IDL measurement

IGF2R FGFBP3

1.70e-0358312EFO_0022149
Diseasephospholipids:total lipids ratio

CD300LG IGF2R NCAN

1.72e-03227313EFO_0020946
Diseasevery low density lipoprotein cholesterol measurement, free cholesterol:total lipids ratio

CD300LG IGF2R HCAR1

1.99e-03239313EFO_0008317, EFO_0020945
Diseasecholesteryl esters:total lipids ratio, high density lipoprotein cholesterol measurement

CD300LG IGF2R HCAR1

2.09e-03243313EFO_0004612, EFO_0020944
Diseasecholesterol in large VLDL measurement

CD300LG IGF2R

2.13e-0365312EFO_0021902
Diseasevery low density lipoprotein cholesterol measurement, cholesteryl esters:total lipids ratio

CD300LG IGF2R HCAR1

2.64e-03264313EFO_0008317, EFO_0020944
Diseasemetabolite measurement

MTNR1B NBAS CYP4F2 IGF2R

2.69e-03560314EFO_0004725
Diseasemonounsaturated fatty acids; 16:1, 18:1 measurement

CD300LG IGF2R

3.05e-0378312EFO_0022187
Diseasevery low density lipoprotein cholesterol measurement, phospholipids:total lipids ratio

CD300LG IGF2R HCAR1

3.48e-03291313EFO_0008317, EFO_0020946
Diseaselipoprotein measurement, phospholipid measurement

CD300LG NCAN

3.61e-0385312EFO_0004639, EFO_0004732
Diseasecholesteryl ester measurement, high density lipoprotein cholesterol measurement

CD300LG NCAN HCAR1

4.23e-03312313EFO_0004612, EFO_0010351
Diseasetotal cholesterol measurement, high density lipoprotein cholesterol measurement

CD300LG NCAN HCAR1

4.34e-03315313EFO_0004574, EFO_0004612
Diseasecholesteryl ester measurement, intermediate density lipoprotein measurement

CD300LG IGF2R

4.40e-0394312EFO_0008595, EFO_0010351
Diseasephospholipid measurement, high density lipoprotein cholesterol measurement

CD300LG NCAN HCAR1

4.58e-03321313EFO_0004612, EFO_0004639

Protein segments in the cluster

PeptideGeneStartEntry
TYYCSRLCRREDWDA

AJM1

691

C9J069
RWFALDCHERRLLYY

ADAP2

276

Q9NPF8
CESLYDPYRNWRHRI

NBEAL1

156

Q6ZS30
PERCAAYAARRAHFW

FGFBP3

96

Q8TAT2
DECLSYLCRWIHYRR

PRAMEF17

161

Q5VTA0
YWSTRYANRRCRYLC

KMT2C

4586

Q8NEZ4
YICHSMAYHRIYRRW

MTNR1B

141

P49286
RSHAYYVCAWDRRLA

MYADM

281

Q96S97
RRVAWSYDCTLLAYA

NBAS

136

A2RRP1
RHCAYRCYATWRFGS

P2RX7

546

Q99572
DACYRYDPHLNRWLR

KLHL26

381

Q53HC5
HYALCRYAEWEERIS

GBA2

446

Q9HCG7
AWTYAFYHNGRRLRC

CYP4F8

36

P98187
RDQLCYYHWGRVRSS

REXO1L1P

431

Q8IX06
IACRDLFQDTYHRYW

COQ8B

506

Q96D53
AWTYAFYDNCRRLRC

CYP4F2

36

P78329
GRRYNCYKHHWSDSR

DNAJC13

111

O75165
TVDYCHSYELFNRRW

HEPN1

56

Q6WQI6
LVSFRYHCRLYNEWR

MARCHF3

201

Q86UD3
RTDYYLRRRHWAFGD

HCAR1

71

Q9BXC0
AQCRAAHYRWVRRKY

CACNA1H

1471

O95180
FDRCYERGLAWYRSL

HS3ST6

126

Q96QI5
WRATRDMCRYRHNYP

OGFR

66

Q9NZT2
CRYEIEWITEYACHR

IGF2R

306

P11717
DEECYYHWGRLRRNR

REXO1

991

Q8N1G1
WSCHWDRDHRRYFYV

FNBP4

601

Q8N3X1
VHIYNRWRNSEIRCY

NBEA

331

Q8NFP9
RDHPTLCISLYRYWR

PNLDC1

476

Q8NA58
QGHCYRYFAHRRAWE

NCAN

1096

O14594
LLVWYCRDFAERLHY

PRDM1

196

O75626
EVDRRWYFYRHRSCP

RHBDL1

181

O75783
QCTYREELRDHRKYW

CD300LG

36

Q6UXG3
YLRDFLRYWRIEKCH

SPTLC2

86

O15270
VRFYYLDEHRSCIRW

PLCH2

66

O75038
CFLHRLISALRYYWD

RNF123

556

Q5XPI4
RCDPISEHNRLYWYR

TRBV7-9

41

P04435
WNALYRYRACDHCLR

SMYD5

61

Q6GMV2