Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionextracellular matrix structural constituent

THBS1 FRAS1 FBN1 FBN2 VWF MATN2 EFEMP2 LAMA2 DMBT1 EDIL3

5.12e-091888210GO:0005201
GeneOntologyMolecularFunctioncalcium ion binding

BMP1 THBS1 EYS SCUBE1 FBN1 FBN2 SCUBE2 MATN2 EFEMP2 LRP2 SCUBE3 DLL1 EDIL3 NOTCH2 NOTCH4 ITPR1

5.42e-087498216GO:0005509
GeneOntologyMolecularFunctionextracellular matrix constituent conferring elasticity

FBN1 FBN2 EFEMP2

1.43e-0512823GO:0030023
GeneOntologyMolecularFunctionstructural molecule activity conferring elasticity

FBN1 FBN2 EFEMP2

2.35e-0514823GO:0097493
GeneOntologyMolecularFunctionlow-density lipoprotein particle binding

THBS1 PCSK9 SORL1

5.21e-0518823GO:0030169
GeneOntologyMolecularFunctionstructural molecule activity

THBS1 FRAS1 FBN1 FBN2 VWF LLGL1 MATN2 EFEMP2 COPB2 LAMA2 CTBP2 DMBT1 EDIL3

6.54e-058918213GO:0005198
GeneOntologyMolecularFunctionlow-density lipoprotein particle receptor binding

LDLRAP1 LRP2 PCSK9

3.64e-0434823GO:0050750
GeneOntologyMolecularFunctionlipoprotein particle binding

THBS1 PCSK9 SORL1

3.97e-0435823GO:0071813
GeneOntologyMolecularFunctionprotein-lipid complex binding

THBS1 PCSK9 SORL1

3.97e-0435823GO:0071814
GeneOntologyMolecularFunctionlipoprotein particle receptor binding

LDLRAP1 LRP2 PCSK9

5.48e-0439823GO:0070325
GeneOntologyMolecularFunctionprotease binding

THBS1 VWF TIMP4 TNFAIP3 FAS

8.99e-04181825GO:0002020
GeneOntologyMolecularFunctionmyosin II binding

LLGL1 TRIOBP

1.26e-0313822GO:0045159
GeneOntologyMolecularFunctionpeptidase activity

PCSK5 USP26 BMP1 ATXN3L ADAM7 ADAM5 TNFAIP3 AGBL5 PCSK9

1.43e-03654829GO:0008233
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

ZNF502 ZNF569 ZNF558 ZNF398 ZBTB41 ZNF772 ZNF619 ZBTB1 CASZ1 ZNF879 NOTCH2 NOTCH4 ZNF518A ZNF646

1.72e-0314128214GO:0000981
GeneOntologyMolecularFunctionK63-linked deubiquitinase activity

ATXN3L TNFAIP3

1.93e-0316822GO:0061578
GeneOntologyMolecularFunctionmetalloendopeptidase inhibitor activity

TIMP4 WFIKKN2

1.93e-0316822GO:0008191
GeneOntologyMolecularFunctionlow-density lipoprotein particle receptor activity

LRP2 SORL1

1.93e-0316822GO:0005041
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

ZNF502 ATXN3L ZNF569 ZNF558 ZNF398 ZBTB41 ZNF772 ZNF619 BCOR ZBTB1 CASZ1 ZNF879 ZNF518A ZNF646

2.33e-0314598214GO:0000977
GeneOntologyBiologicalProcessregulation of cellular response to growth factor stimulus

THBS1 FBN1 FBN2 WFIKKN2 LRP2 SCUBE3 DLL1 NOTCH2 PPM1A SORL1

3.83e-064127910GO:0090287
GeneOntologyBiologicalProcessmarginal zone B cell differentiation

TNFAIP3 DLL1 NOTCH2

6.37e-0610793GO:0002315
GeneOntologyBiologicalProcessregulation of transmembrane receptor protein serine/threonine kinase signaling pathway

THBS1 FBN1 FBN2 WFIKKN2 LRP2 SCUBE3 NOTCH2 PPM1A SORL1

7.11e-06347799GO:0090092
GeneOntologyBiologicalProcessregulation of BMP signaling pathway

FBN1 LRP2 SCUBE3 NOTCH2 PPM1A SORL1

1.11e-05131796GO:0030510
GeneOntologyBiologicalProcesspositive regulation of smooth muscle cell-matrix adhesion

PCSK5 EFEMP2

1.45e-052792GO:1905609
GeneOntologyBiologicalProcessanimal organ morphogenesis

BMP1 THBS1 FRAS1 FBN2 SCUBE2 EFEMP2 LRP2 LAMA2 TRIOBP NTNG1 TNFAIP3 BCOR DLL1 CASZ1 NOTCH2 ITPR1

2.08e-0512697916GO:0009887
GeneOntologyBiologicalProcessgliogenesis

MATN2 SYNE2 LRP2 LAMA2 DLL1 FAS CASZ1 CNTN2 NOTCH2

4.24e-05435799GO:0042063
GeneOntologyBiologicalProcessdendrite regeneration

MATN2 FAS

4.33e-053792GO:0031104
GeneOntologyBiologicalProcessreceptor-mediated endocytosis

LDLRAP1 LRP2 LRRTM1 DMBT1 DLL1 CNTN2 PCSK9 SORL1

4.45e-05337798GO:0006898
GeneOntologyBiologicalProcesstransforming growth factor beta receptor superfamily signaling pathway

THBS1 FBN1 FBN2 WFIKKN2 LRP2 SCUBE3 NOTCH2 PPM1A SORL1

5.05e-05445799GO:0141091
GeneOntologyBiologicalProcesssequestering of TGFbeta in extracellular matrix

FBN1 FBN2

8.65e-054792GO:0035583
GeneOntologyBiologicalProcesscell surface receptor protein serine/threonine kinase signaling pathway

THBS1 FBN1 FBN2 WFIKKN2 LRP2 SCUBE3 NOTCH2 PPM1A SORL1

9.31e-05482799GO:0007178
GeneOntologyBiologicalProcessBMP signaling pathway

FBN1 LRP2 SCUBE3 NOTCH2 PPM1A SORL1

1.10e-04197796GO:0030509
GeneOntologyBiologicalProcessB cell differentiation

POLM TNFAIP3 DLL1 FAS ZBTB1 NOTCH2

1.22e-04201796GO:0030183
GeneOntologyBiologicalProcessliver development

PTPN3 VWF TNFAIP3 NOTCH2 PCSK9 ITPR1

1.26e-04202796GO:0001889
GeneOntologyBiologicalProcesshepaticobiliary system development

PTPN3 VWF TNFAIP3 NOTCH2 PCSK9 ITPR1

1.36e-04205796GO:0061008
GeneOntologyBiologicalProcessregulation of smooth muscle cell-matrix adhesion

PCSK5 EFEMP2

1.44e-045792GO:2000097
GeneOntologyBiologicalProcessregulation of protein catabolic process

USP26 ATXN3L PTPN3 TIMP4 LRP2 TNFAIP3 PCSK9 SORL1

1.65e-04407798GO:0042176
GeneOntologyBiologicalProcesspositive regulation of smooth muscle cell differentiation

EFEMP2 NOTCH2 NOTCH4

1.65e-0428793GO:0051152
GeneOntologyBiologicalProcesscell-substrate adhesion

PCSK5 ATXN3L THBS1 VWF EFEMP2 TRIOBP EDIL3 CNTN2

1.73e-04410798GO:0031589
GeneOntologyBiologicalProcessresponse to BMP

FBN1 LRP2 SCUBE3 NOTCH2 PPM1A SORL1

1.76e-04215796GO:0071772
GeneOntologyBiologicalProcesscellular response to BMP stimulus

FBN1 LRP2 SCUBE3 NOTCH2 PPM1A SORL1

1.76e-04215796GO:0071773
GeneOntologyBiologicalProcessnegative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway

FBN1 FBN2 WFIKKN2 LRP2 PPM1A SORL1

1.90e-04218796GO:0090101
GeneOntologyBiologicalProcessnegative regulation of cGMP-mediated signaling

THBS1 PDE11A

2.15e-046792GO:0010754
GeneOntologyBiologicalProcessnegative regulation of BMP signaling pathway

FBN1 LRP2 PPM1A SORL1

2.53e-0480794GO:0030514
GeneOntologyBiologicalProcesspositive regulation of cell-substrate adhesion

PCSK5 THBS1 EFEMP2 TRIOBP EDIL3

2.70e-04149795GO:0010811
GeneOntologyBiologicalProcessnegative regulation of cellular response to growth factor stimulus

THBS1 FBN1 LRP2 PPM1A SORL1

2.78e-04150795GO:0090288
GeneOntologyBiologicalProcesssmooth muscle cell-matrix adhesion

PCSK5 EFEMP2

3.00e-047792GO:0061302
GeneOntologyBiologicalProcessendocytosis

LDLRAP1 THBS1 XKR9 LRP2 DGKQ LRRTM1 DMBT1 DLL1 CNTN2 PCSK9 SORL1

3.02e-048277911GO:0006897
GeneOntologyBiologicalProcessaxonogenesis

LLGL1 MATN2 TTL LRP2 LAMA2 NTNG1 CNTN2 NOTCH2 TIAM2

3.09e-04566799GO:0007409
GeneOntologyBiologicalProcessregulation of receptor-mediated endocytosis involved in cholesterol transport

LDLRAP1 PCSK9

4.00e-048792GO:1905600
GeneOntologyBiologicalProcessmaintenance of protein location in extracellular region

FBN1 FBN2

4.00e-048792GO:0071694
GeneOntologyBiologicalProcessnegative regulation of membrane protein ectodomain proteolysis

PTPN3 TIMP4

4.00e-048792GO:0051045
GeneOntologyBiologicalProcessmature B cell differentiation involved in immune response

TNFAIP3 DLL1 NOTCH2

4.14e-0438793GO:0002313
GeneOntologyBiologicalProcessregulation of cell-substrate adhesion

PCSK5 ATXN3L THBS1 EFEMP2 TRIOBP EDIL3

4.31e-04254796GO:0010810
GeneOntologyBiologicalProcesspositive regulation of endocytic recycling

EIPR1 SORL1

5.12e-049792GO:2001137
GeneOntologyBiologicalProcesscell morphogenesis involved in neuron differentiation

LLGL1 MATN2 TTL LRP2 LAMA2 TRIOBP NTNG1 CNTN2 NOTCH2 TIAM2

5.57e-047487910GO:0048667
GeneOntologyBiologicalProcessregulation of proteolysis

USP26 ATXN3L MICAL1 PTPN3 THBS1 TIMP4 WFIKKN2 FAS CNTN2 NOTCH4

5.57e-047487910GO:0030162
GeneOntologyBiologicalProcesskidney development

PCSK5 FRAS1 FBN1 LRP2 DLL1 NOTCH2 PCSK9

5.58e-04372797GO:0001822
GeneOntologyBiologicalProcesscell morphogenesis

LLGL1 MATN2 ADAM7 TTL LRP2 LAMA2 TRIOBP NTNG1 CNTN2 NOTCH2 TIAM2 NOTCH4 ITPR1

5.71e-0411947913GO:0000902
GeneOntologyBiologicalProcessproximal tubule development

DLL1 NOTCH2

6.39e-0410792GO:0072014
GeneOntologyBiologicalProcesspositive regulation of smoothened signaling pathway

SCUBE1 SCUBE2 SCUBE3

6.83e-0445793GO:0045880
GeneOntologyBiologicalProcessrenal system development

PCSK5 FRAS1 FBN1 LRP2 DLL1 NOTCH2 PCSK9

6.94e-04386797GO:0072001
GeneOntologyBiologicalProcessepithelial cell proliferation involved in liver morphogenesis

TNFAIP3 NOTCH2 ITPR1

7.29e-0446793GO:0072575
GeneOntologyBiologicalProcesshepatocyte proliferation

TNFAIP3 NOTCH2 ITPR1

7.29e-0446793GO:0072574
GeneOntologyBiologicalProcesspositive regulation of muscle cell differentiation

EFEMP2 LAMA2 NOTCH2 NOTCH4

7.36e-04106794GO:0051149
GeneOntologyBiologicalProcessaxon development

LLGL1 MATN2 TTL LRP2 LAMA2 NTNG1 CNTN2 NOTCH2 TIAM2

7.66e-04642799GO:0061564
GeneOntologyBiologicalProcessmature B cell differentiation

TNFAIP3 DLL1 NOTCH2

7.77e-0447793GO:0002335
GeneOntologyBiologicalProcesssequestering of extracellular ligand from receptor

FBN1 FBN2

7.79e-0411792GO:0035581
GeneOntologyBiologicalProcessreceptor-mediated endocytosis involved in cholesterol transport

LDLRAP1 PCSK9

7.79e-0411792GO:0090118
GeneOntologyBiologicalProcessregulation of cell adhesion

PCSK5 ATXN3L THBS1 EFEMP2 LAMA2 TRIOBP TNFAIP3 DLL1 EDIL3 ZBTB1 NOTCH4

7.85e-049277911GO:0030155
GeneOntologyBiologicalProcessprotein processing

PCSK5 BMP1 THBS1 CNTN2 NOTCH4 PCSK9

7.89e-04285796GO:0016485
GeneOntologyBiologicalProcessregulation of transforming growth factor beta receptor signaling pathway

THBS1 FBN1 FBN2 WFIKKN2 PPM1A

8.56e-04192795GO:0017015
GeneOntologyBiologicalProcessliver morphogenesis

TNFAIP3 NOTCH2 ITPR1

8.78e-0449793GO:0072576
GeneOntologyBiologicalProcessregulation of cellular response to transforming growth factor beta stimulus

THBS1 FBN1 FBN2 WFIKKN2 PPM1A

9.18e-04195795GO:1903844
GeneOntologyBiologicalProcesscell fate determination

DLL1 NOTCH2 NOTCH4

9.31e-0450793GO:0001709
GeneOntologyBiologicalProcessregulation of intracellular sterol transport

LDLRAP1 PCSK9

9.32e-0412792GO:0032380
GeneOntologyBiologicalProcessregulation of intracellular cholesterol transport

LDLRAP1 PCSK9

9.32e-0412792GO:0032383
GeneOntologyBiologicalProcessregulation of vesicle-mediated transport

LDLRAP1 MICAL1 LRP2 DGKQ LRRTM1 EIPR1 DLL1 PCSK9 SORL1

1.00e-03667799GO:0060627
GeneOntologyBiologicalProcessregulation of muscle cell differentiation

EFEMP2 LAMA2 DLL1 NOTCH2 NOTCH4

1.01e-03199795GO:0051147
GeneOntologyBiologicalProcessregulation of osteoclast development

FBN1 NOTCH2

1.10e-0313792GO:2001204
GeneOntologyBiologicalProcessextracellular regulation of signal transduction

FBN1 FBN2

1.10e-0313792GO:1900115
GeneOntologyBiologicalProcessextracellular negative regulation of signal transduction

FBN1 FBN2

1.10e-0313792GO:1900116
GeneOntologyBiologicalProcessregulation of intracellular lipid transport

LDLRAP1 PCSK9

1.10e-0313792GO:0032377
GeneOntologyBiologicalProcessregulation of smooth muscle cell differentiation

EFEMP2 NOTCH2 NOTCH4

1.17e-0354793GO:0051150
GeneOntologyBiologicalProcessNotch signaling pathway

LLGL1 TIMP4 DLL1 NOTCH2 NOTCH4

1.28e-03210795GO:0007219
GeneOntologyBiologicalProcesspositive regulation of integrin-mediated signaling pathway

PCSK5 LAMA2

1.28e-0314792GO:2001046
GeneOntologyBiologicalProcessleft/right axis specification

DLL1 NOTCH2

1.28e-0314792GO:0070986
GeneOntologyBiologicalProcesspositive regulation of hepatocyte proliferation

TNFAIP3 ITPR1

1.28e-0314792GO:2000347
GeneOntologyBiologicalProcesspositive regulation of cell differentiation

FBN2 SCUBE2 ADAM7 EFEMP2 LRP2 SCUBE3 LAMA2 DMBT1 ZBTB1 NOTCH2 TIAM2 NOTCH4

1.28e-0311417912GO:0045597
GeneOntologyBiologicalProcessgland development

PTPN3 VWF TNFAIP3 ZBTB1 NOTCH2 NOTCH4 PCSK9 ITPR1

1.32e-03558798GO:0048732
GeneOntologyBiologicalProcesscellular response to growth factor stimulus

THBS1 FBN1 FBN2 WFIKKN2 LRP2 SCUBE3 DLL1 NOTCH2 PPM1A SORL1

1.47e-038507910GO:0071363
GeneOntologyBiologicalProcessengulfment of apoptotic cell

THBS1 XKR9

1.47e-0315792GO:0043652
GeneOntologyBiologicalProcessregulation of cGMP-mediated signaling

THBS1 PDE11A

1.47e-0315792GO:0010752
GeneOntologyCellularComponentextracellular matrix

BMP1 THBS1 FRAS1 EYS FBN1 FBN2 VWF TIMP4 MATN2 EFEMP2 LAMA2 LRRTM1 DMBT1 EDIL3 ANGPTL5

3.42e-086568215GO:0031012
GeneOntologyCellularComponentexternal encapsulating structure

BMP1 THBS1 FRAS1 EYS FBN1 FBN2 VWF TIMP4 MATN2 EFEMP2 LAMA2 LRRTM1 DMBT1 EDIL3 ANGPTL5

3.56e-086588215GO:0030312
GeneOntologyCellularComponentcollagen-containing extracellular matrix

BMP1 THBS1 FRAS1 EYS FBN1 FBN2 VWF MATN2 EFEMP2 LAMA2 DMBT1 EDIL3 ANGPTL5

1.40e-075308213GO:0062023
GeneOntologyCellularComponentmicrofibril

FBN1 FBN2 EFEMP2

1.62e-0513823GO:0001527
GeneOntologyCellularComponentcell surface

THBS1 SCUBE1 VWF SCUBE2 CD163L1 LRP2 SCUBE3 LRRTM1 FAS CNTN2 NOTCH2 NOTCH4 PCSK9 SORL1

9.82e-0511118214GO:0009986
GeneOntologyCellularComponentbasement membrane

FRAS1 FBN1 MATN2 EFEMP2 LAMA2

1.19e-04122825GO:0005604
GeneOntologyCellularComponentside of membrane

LDLRAP1 PTPN3 THBS1 SCUBE1 VWF CD163L1 LRP2 NTNG1 FAS CNTN2 PCSK9

6.02e-048758211GO:0098552
HumanPhenoAortic valve stenosis

LDLRAP1 FBN1 VWF EFEMP2 BCOR NOTCH2 PCSK9

4.67e-06113327HP:0001650
HumanPhenoAbnormal aortic valve morphology

LDLRAP1 FBN1 FBN2 VWF POLR1A EFEMP2 BCOR FAS NOTCH2 PCSK9

6.25e-062893210HP:0001646
HumanPhenoAbnormal aortic valve physiology

LDLRAP1 FBN1 VWF EFEMP2 BCOR FAS NOTCH2 PCSK9

1.70e-05192328HP:0031652
HumanPhenoAbnormal mitral valve morphology

LDLRAP1 FBN1 FBN2 VWF POLR1A BCOR FAS NOTCH2 PCSK9

1.86e-05257329HP:0001633
HumanPhenoAbnormal heart valve physiology

LDLRAP1 FBN1 FBN2 VWF POLR1A EFEMP2 BCOR FAS NOTCH2 PCSK9 ITPR1

1.86e-054033211HP:0031653
HumanPhenoAbnormal atrioventricular valve morphology

LDLRAP1 FBN1 FBN2 VWF POLR1A EFEMP2 BCOR FAS NOTCH2 PCSK9

3.39e-053503210HP:0006705
HumanPhenoAbnormal atrioventricular valve physiology

LDLRAP1 FBN1 FBN2 POLR1A EFEMP2 FAS NOTCH2 PCSK9

3.87e-05215328HP:0031650
HumanPhenoPulmonary artery dilatation

FBN1 POLR1A EFEMP2

7.82e-0514323HP:0004927
HumanPhenoAbnormal mitral valve physiology

LDLRAP1 FBN1 FBN2 POLR1A FAS NOTCH2 PCSK9

9.74e-05180327HP:0031481
HumanPhenoAbnormal upper to lower segment ratio

FBN1 FBN2

1.14e-043322HP:0012772
HumanPhenoAbnormal heart valve morphology

LDLRAP1 FBN1 FBN2 VWF POLR1A EFEMP2 BCOR FAS CASZ1 NOTCH2 PCSK9 ITPR1

1.27e-045883212HP:0001654
HumanPhenoKyphosis

BMP1 FBN1 FBN2 SYNE2 LAMA2 NTNG1 BCOR CASZ1 NOTCH2 ITPR1 PDE11A

1.66e-045103211HP:0002808
HumanPhenoAtrioventricular valve regurgitation

LDLRAP1 FBN1 FBN2 POLR1A EFEMP2 FAS PCSK9

1.66e-04196327HP:0034376
DomainEGF

PCSK5 BMP1 THBS1 FRAS1 EYS SCUBE1 FBN1 FBN2 SCUBE2 MATN2 EFEMP2 LRP2 SCUBE3 LAMA2 NTNG1 DLL1 EDIL3 NOTCH2 NOTCH4 SORL1

1.36e-202358220SM00181
DomainEGF-like_dom

PCSK5 BMP1 THBS1 FRAS1 EYS SCUBE1 FBN1 FBN2 SCUBE2 MATN2 EFEMP2 LRP2 SCUBE3 LAMA2 NTNG1 DLL1 EDIL3 NOTCH2 NOTCH4 SORL1

4.35e-202498220IPR000742
DomainEGF_CA

BMP1 THBS1 EYS SCUBE1 FBN1 FBN2 SCUBE2 MATN2 EFEMP2 LRP2 SCUBE3 DLL1 EDIL3 NOTCH2 NOTCH4

4.79e-181228215SM00179
DomainEGF-like_Ca-bd_dom

BMP1 THBS1 EYS SCUBE1 FBN1 FBN2 SCUBE2 MATN2 EFEMP2 LRP2 SCUBE3 DLL1 EDIL3 NOTCH2 NOTCH4

6.16e-181248215IPR001881
DomainASX_HYDROXYL

BMP1 EYS SCUBE1 FBN1 FBN2 SCUBE2 MATN2 EFEMP2 LRP2 SCUBE3 DLL1 EDIL3 NOTCH2 NOTCH4

1.01e-171008214PS00010
DomainEGF-type_Asp/Asn_hydroxyl_site

BMP1 EYS SCUBE1 FBN1 FBN2 SCUBE2 MATN2 EFEMP2 LRP2 SCUBE3 DLL1 EDIL3 NOTCH2 NOTCH4

2.37e-171068214IPR000152
DomainEGF-like_CS

BMP1 THBS1 EYS SCUBE1 FBN1 FBN2 SCUBE2 MATN2 EFEMP2 LRP2 SCUBE3 LAMA2 NTNG1 DLL1 EDIL3 NOTCH2 NOTCH4 SORL1

6.04e-172618218IPR013032
DomainEGF_2

BMP1 THBS1 EYS SCUBE1 FBN1 FBN2 SCUBE2 MATN2 EFEMP2 LRP2 SCUBE3 LAMA2 NTNG1 DLL1 EDIL3 NOTCH2 NOTCH4 SORL1

7.91e-172658218PS01186
DomainGrowth_fac_rcpt_

PCSK5 BMP1 FRAS1 EYS SCUBE1 FBN1 FBN2 SCUBE2 MATN2 EFEMP2 LRP2 SCUBE3 DLL1 NOTCH2 NOTCH4

2.09e-161568215IPR009030
DomainEGF_3

BMP1 THBS1 EYS SCUBE1 FBN1 FBN2 SCUBE2 MATN2 EFEMP2 LRP2 SCUBE3 NTNG1 DLL1 EDIL3 NOTCH2 NOTCH4 SORL1

2.18e-162358217PS50026
DomainEGF_Ca-bd_CS

BMP1 EYS SCUBE1 FBN1 FBN2 SCUBE2 EFEMP2 LRP2 SCUBE3 DLL1 EDIL3 NOTCH2 NOTCH4

2.89e-16978213IPR018097
DomainEGF_CA

BMP1 EYS SCUBE1 FBN1 FBN2 SCUBE2 EFEMP2 LRP2 SCUBE3 DLL1 EDIL3 NOTCH2 NOTCH4

3.81e-16998213PS01187
DomainEGF_CA

BMP1 THBS1 SCUBE1 FBN1 FBN2 SCUBE2 MATN2 EFEMP2 LRP2 SCUBE3 NOTCH2 NOTCH4

2.61e-15868212PF07645
DomainEGF_1

BMP1 THBS1 EYS SCUBE1 FBN1 FBN2 SCUBE2 EFEMP2 LRP2 SCUBE3 LAMA2 NTNG1 DLL1 EDIL3 NOTCH2 NOTCH4

1.70e-142558216PS00022
DomaincEGF

SCUBE1 FBN1 FBN2 SCUBE2 MATN2 EFEMP2 LRP2 SCUBE3

1.43e-1326828IPR026823
DomaincEGF

SCUBE1 FBN1 FBN2 SCUBE2 MATN2 EFEMP2 LRP2 SCUBE3

1.43e-1326828PF12662
DomainEGF

BMP1 EYS SCUBE2 MATN2 LRP2 SCUBE3 DLL1 EDIL3 NOTCH2 NOTCH4

1.93e-101268210PF00008
DomainhEGF

EYS FBN2 DLL1 EDIL3 NOTCH2 NOTCH4

2.07e-0928826PF12661
DomainCUB

BMP1 SCUBE1 SCUBE2 SCUBE3 DMBT1

2.36e-0649825PF00431
DomainCUB

BMP1 SCUBE1 SCUBE2 SCUBE3 DMBT1

2.62e-0650825SM00042
Domain-

BMP1 SCUBE1 SCUBE2 SCUBE3 DMBT1

3.19e-06528252.60.120.290
DomainCUB

BMP1 SCUBE1 SCUBE2 SCUBE3 DMBT1

3.51e-0653825PS01180
DomainEphrin_rec_like

PCSK5 SCUBE1 SCUBE2 SCUBE3

4.07e-0625824SM01411
DomainTyr-kin_ephrin_A/B_rcpt-like

PCSK5 SCUBE1 SCUBE2 SCUBE3

4.07e-0625824IPR011641
DomainCUB_dom

BMP1 SCUBE1 SCUBE2 SCUBE3 DMBT1

5.05e-0657825IPR000859
DomainEphrin_rec_like

SCUBE1 SCUBE2 SCUBE3

1.31e-0511823PF07699
DomainEGF_3

SCUBE1 SCUBE2 SCUBE3

1.74e-0512823PF12947
DomainEGF_dom

SCUBE1 SCUBE2 SCUBE3

1.74e-0512823IPR024731
Domainzf-C2H2

ZNF502 ZNF569 ZNF558 ZNF398 ZBTB41 ZNF772 ZNF619 ZBTB1 CASZ1 ZNF879 ZNF518A ZNF646

4.75e-056938212PF00096
DomainFBN

FBN1 FBN2

5.70e-053822IPR011398
DomainSRCR

CD163L1 HHIPL1 DMBT1

1.02e-0421823PF00530
DomainNotch

NOTCH2 NOTCH4

1.14e-044822IPR008297
DomainNODP

NOTCH2 NOTCH4

1.14e-044822PF07684
DomainNotch_NODP_dom

NOTCH2 NOTCH4

1.14e-044822IPR011656
DomainNotch_NOD_dom

NOTCH2 NOTCH4

1.14e-044822IPR010660
DomainNOD

NOTCH2 NOTCH4

1.14e-044822PF06816
DomainNOD

NOTCH2 NOTCH4

1.14e-044822SM01338
DomainNODP

NOTCH2 NOTCH4

1.14e-044822SM01339
DomainZINC_FINGER_C2H2_2

ZNF502 ZNF569 ZNF558 ZNF398 ZBTB41 ZNF772 ZNF619 ZBTB1 CASZ1 ZNF879 ZNF518A ZNF646

1.37e-047758212PS50157
DomainZINC_FINGER_C2H2_1

ZNF502 ZNF569 ZNF558 ZNF398 ZBTB41 ZNF772 ZNF619 ZBTB1 CASZ1 ZNF879 ZNF518A ZNF646

1.41e-047778212PS00028
DomainSR

CD163L1 HHIPL1 DMBT1

1.75e-0425823SM00202
Domain-

CD163L1 HHIPL1 DMBT1

1.75e-04258233.10.250.10
DomainZnf_C2H2-like

ZNF502 ZNF569 ZNF558 ZNF398 ZBTB41 ZNF772 ZNF619 ZBTB1 CASZ1 ZNF879 ZNF518A ZNF646

1.76e-047968212IPR015880
DomainLNR

NOTCH2 NOTCH4

1.89e-045822PS50258
DomainZnf_C2H2

ZNF502 ZNF569 ZNF558 ZNF398 ZBTB41 ZNF772 ZNF619 ZBTB1 CASZ1 ZNF879 ZNF518A ZNF646

1.96e-048058212IPR007087
DomainSRCR_1

CD163L1 HHIPL1 DMBT1

1.97e-0426823PS00420
DomainSRCR_2

CD163L1 HHIPL1 DMBT1

1.97e-0426823PS50287
DomainSRCR-like_dom

CD163L1 HHIPL1 DMBT1

1.97e-0426823IPR017448
DomainZnF_C2H2

ZNF502 ZNF569 ZNF558 ZNF398 ZBTB41 ZNF772 ZNF619 ZBTB1 CASZ1 ZNF879 ZNF518A ZNF646

2.02e-048088212SM00355
DomainZnf_C2H2/integrase_DNA-bd

ZNF502 ZNF569 ZNF558 ZNF398 ZBTB41 ZNF772 ZNF619 ZBTB1 ZNF879 ZNF518A ZNF646

2.19e-046948211IPR013087
DomainSRCR

CD163L1 HHIPL1 DMBT1

2.21e-0427823IPR001190
DomainVWC

THBS1 FRAS1 VWF

2.47e-0428823PF00093
Domain-

PCSK5 LAMA2 NTNG1 EDIL3

2.98e-04738242.60.120.260
DomainTB

FBN1 FBN2

3.94e-047822PF00683
DomainNotch_dom

NOTCH2 NOTCH4

3.94e-047822IPR000800
DomainNotch

NOTCH2 NOTCH4

3.94e-047822PF00066
DomainNL

NOTCH2 NOTCH4

3.94e-047822SM00004
Domainzf-C2H2_6

ZNF502 ZNF569 ZNF558 ZBTB41 ZNF619 ZNF879 ZNF646

4.59e-04314827PF13912
Domain-

FBN1 FBN2

5.24e-0488223.90.290.10
DomainVWFC_1

THBS1 FRAS1 VWF

5.25e-0436823PS01208
DomainVWC

THBS1 FRAS1 VWF

6.16e-0438823SM00214
DomainVWFC_2

THBS1 FRAS1 VWF

6.16e-0438823PS50184
Domain-

LRP2 HHIPL1 SORL1

6.65e-04398232.120.10.30
DomainTB

FBN1 FBN2

6.72e-049822PS51364
DomainTB_dom

FBN1 FBN2

6.72e-049822IPR017878
Domain-

ZNF502 ZNF569 ZNF558 ZNF398 ZBTB41 ZNF772 ZNF619 ZBTB1 ZNF879 ZNF646

7.63e-0467982103.30.160.60
DomainGalactose-bd-like

PCSK5 LAMA2 NTNG1 EDIL3

7.80e-0494824IPR008979
DomainVWF_dom

THBS1 FRAS1 VWF

8.28e-0442823IPR001007
DomainPeptidase_S8_subtilisin-rel

PCSK5 PCSK9

8.38e-0410822IPR015500
DomainSUBTILASE_ASP

PCSK5 PCSK9

8.38e-0410822PS00136
DomainSUBTILASE_HIS

PCSK5 PCSK9

8.38e-0410822PS00137
DomainSUBTILASE_SER

PCSK5 PCSK9

8.38e-0410822PS00138
Domain-

PCSK5 PCSK9

1.02e-03118223.40.50.200
DomainPeptidase_S8/S53_dom

PCSK5 PCSK9

1.02e-0311822IPR000209
DomainPeptidase_S8

PCSK5 PCSK9

1.02e-0311822PF00082
DomainLaminin_G_1

EYS LAMA2

1.02e-0311822PF00054
Domain6-blade_b-propeller_TolB-like

LRP2 HHIPL1 SORL1

1.08e-0346823IPR011042
DomainTIL_dom

VWF LRP2

1.67e-0314822IPR002919
DomainLdl_recept_b

LRP2 SORL1

1.67e-0314822PF00058
DomainLDLRB

LRP2 SORL1

1.67e-0314822PS51120
DomainLY

LRP2 SORL1

1.93e-0315822SM00135
DomainLDLR_classB_rpt

LRP2 SORL1

1.93e-0315822IPR000033
DomainLaminin_G

THBS1 EYS LAMA2

2.12e-0358823IPR001791
DomainLaminin_N

LAMA2 NTNG1

2.20e-0316822IPR008211
DomainLAMININ_NTER

LAMA2 NTNG1

2.20e-0316822PS51117
DomainLaminin_N

LAMA2 NTNG1

2.20e-0316822PF00055
DomainLamNT

LAMA2 NTNG1

2.20e-0316822SM00136
DomainPropept_inh

PCSK5 PCSK9

2.48e-0317822IPR009020
DomainFurin_repeat

PCSK5 FRAS1

2.78e-0318822IPR006212
DomainFU

PCSK5 FRAS1

2.78e-0318822SM00261
DomainVWC_out

FRAS1 VWF

3.10e-0319822SM00215
DomainTPR-like_helical_dom

POLR1A CNOT10 COPB2 TTC34 ANAPC5

3.62e-03233825IPR011990
PathwayREACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

BMP1 THBS1 SCUBE1 FBN1 FBN2 VWF EFEMP2 SCUBE3 LAMA2

8.92e-06300659M610
PathwayREACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

BMP1 THBS1 SCUBE1 FBN1 FBN2 VWF EFEMP2 SCUBE3

2.31e-05258658MM14572
PathwayKEGG_MEDICUS_REFERENCE_NOTCH_SIGNALING_PATHWAY

DLL1 NOTCH2 NOTCH4

2.59e-0513653M47423
PathwayWP_NOTCH_SIGNALING_WP268

CTBP2 DLL1 NOTCH2 NOTCH4

5.32e-0545654M39571
PathwayWP_NOTCH_SIGNALING_PATHWAY

CTBP2 DLL1 NOTCH2 NOTCH4

5.81e-0546654MM15971
PathwayKEGG_NOTCH_SIGNALING_PATHWAY

CTBP2 DLL1 NOTCH2 NOTCH4

6.33e-0547654M7946
PathwayREACTOME_PLASMA_LIPOPROTEIN_ASSEMBLY_REMODELING_AND_CLEARANCE

PCSK5 LDLRAP1 BMP1 PCSK9

1.88e-0462654MM14686
PathwayREACTOME_DEFECTIVE_LFNG_CAUSES_SCDO3

NOTCH2 NOTCH4

2.07e-045652M27411
PathwayWP_CANONICAL_AND_NONCANONICAL_NOTCH_SIGNALING

DLL1 NOTCH2 NOTCH4

2.53e-0427653M39545
PathwayREACTOME_PRE_NOTCH_PROCESSING_IN_THE_ENDOPLASMIC_RETICULUM

NOTCH2 NOTCH4

3.10e-046652M27068
PathwayREACTOME_PLASMA_LIPOPROTEIN_ASSEMBLY_REMODELING_AND_CLEARANCE

PCSK5 LDLRAP1 BMP1 PCSK9

3.91e-0475654M27032
PathwayREACTOME_MOLECULES_ASSOCIATED_WITH_ELASTIC_FIBRES

FBN1 FBN2 EFEMP2

4.22e-0432653MM14854
PathwayREACTOME_TRANSPORT_OF_RCBL_WITHIN_THE_BODY

LDLRAP1 LRP2

4.33e-047652MM15703
PathwayREACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX

BMP1 SCUBE1 FBN1 FBN2 SCUBE3

4.60e-04140655M587
PathwayREACTOME_TRANSPORT_OF_RCBL_WITHIN_THE_BODY

LDLRAP1 LRP2

5.76e-048652M45025
PathwayREACTOME_MOLECULES_ASSOCIATED_WITH_ELASTIC_FIBRES

FBN1 FBN2 EFEMP2

6.50e-0437653M27134
PathwayREACTOME_ELASTIC_FIBRE_FORMATION

FBN1 FBN2 EFEMP2

7.59e-0439653MM14601
PathwayREACTOME_CGMP_EFFECTS

ITPR1 PDE11A

9.20e-0410652MM15054
PathwayPID_INTEGRIN3_PATHWAY

THBS1 FBN1 EDIL3

1.01e-0343653M53
PathwayWP_NEURAL_CREST_DIFFERENTIATION

CTBP2 DLL1 NOTCH2 NOTCH4

1.03e-0397654MM15926
PathwayREACTOME_ELASTIC_FIBRE_FORMATION

FBN1 FBN2 EFEMP2

1.08e-0344653M26969
PathwayKEGG_MEDICUS_REFERENCE_NOTCH_PROTEOLYTIC_ACTIVATION

NOTCH2 NOTCH4

1.12e-0311652M47865
PathwayWP_NEURAL_CREST_DIFFERENTIATION

CTBP2 DLL1 NOTCH2 NOTCH4

1.20e-03101654M39448
PathwayBIOCARTA_HES_PATHWAY

DLL1 NOTCH2

1.34e-0312652MM1562
PathwayBIOCARTA_HES_PATHWAY

DLL1 NOTCH2

1.34e-0312652M22042
PathwayKEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00380

NOTCH2 NOTCH4

1.34e-0312652M47532
PathwayKEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00381

NOTCH2 NOTCH4

1.34e-0312652M47533
PathwayREACTOME_VITAMIN_D_CALCIFEROL_METABOLISM

LDLRAP1 LRP2

1.34e-0312652M27088
PathwayREACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE

ITPR1 PDE11A

1.58e-0313652MM15015
PathwayKEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00382

NOTCH2 NOTCH4

1.58e-0313652M47534
PathwayWP_FATTY_ACIDS_AND_LIPOPROTEINS_TRANSPORT_IN_HEPATOCYTES

LDLRAP1 CD163L1 LRP2 HHIPL1 DMBT1 PCSK9 SORL1

1.80e-03381657M48063
PathwayREACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX

SCUBE1 FBN1 FBN2 SCUBE3

1.88e-03114654MM14571
Pubmed

The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices.

THBS1 FRAS1 FBN1 VWF MATN2 EFEMP2 LAMA2 DMBT1

6.94e-0916783822159717
Pubmed

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.

PCSK5 BMP1 THBS1 FBN1 VWF MATN2 EFEMP2 LAMA2 PCSK9

8.56e-0924883924006456
Pubmed

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.

BMP1 THBS1 FBN1 FBN2 VWF MATN2 LAMA2 DMBT1

1.00e-0817583828071719
Pubmed

Identification of a novel family of cell-surface proteins expressed in human vascular endothelium.

SCUBE1 SCUBE2 SCUBE3

1.31e-08383312270931
Pubmed

Integrity of intracellular domain of Notch ligand is indispensable for cleavage required for release of the Notch2 intracellular domain.

DLL1 NOTCH2 NOTCH4

1.31e-08383311823422
Pubmed

The relationship of serum SCUBE-1, -2 and -3 levels with clinical findings and ultrasonographic skin thickness in systemic sclerosis patients.

SCUBE1 SCUBE2 SCUBE3

1.31e-08383331991528
Pubmed

Expression patterns of Notch receptors and their ligands Jagged and Delta in human placenta.

DLL1 NOTCH2 NOTCH4

1.31e-07583321726900
Pubmed

Scube3 is expressed in multiple tissues during development but is dispensable for embryonic survival in the mouse.

SCUBE1 SCUBE2 SCUBE3

1.31e-07583323383134
Pubmed

Fibrillin-1 interactions with fibulins depend on the first hybrid domain and provide an adaptor function to tropoelastin.

FBN1 FBN2 EFEMP2

1.31e-07583317255108
Pubmed

Notch controls the magnitude of T helper cell responses by promoting cellular longevity.

FAS NOTCH2 NOTCH4

2.61e-07683322615412
Pubmed

Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia.

PCSK5 FBN1 VWF LLGL1 MATN2 EFEMP2

4.09e-0711883621078624
Pubmed

Notch signaling controls liver development by regulating biliary differentiation.

DLL1 EDIL3 NOTCH2 NOTCH4

4.33e-072683419369401
Pubmed

Human ligands of the Notch receptor.

DLL1 NOTCH2 NOTCH4

4.56e-07783310079256
Pubmed

The distribution of Notch receptors and their ligands during articular cartilage development.

DLL1 NOTCH2 NOTCH4

4.56e-07783312846471
Pubmed

Disruption of Scube2 Impairs Endochondral Bone Formation.

SCUBE1 SCUBE2 SCUBE3

4.56e-07783325639508
Pubmed

Distinct expression patterns of notch family receptors and ligands during development of the mammalian inner ear.

DLL1 NOTCH2 NOTCH4

7.28e-0788339858718
Pubmed

Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.

THBS1 FBN1 FBN2 LRP2 LAMA2

7.88e-077183533541421
Pubmed

Microfibril-associated glycoprotein-2 interacts with fibrillin-1 and fibrillin-2 suggesting a role for MAGP-2 in elastic fiber assembly.

FBN1 FBN2 VWF

1.09e-06983312122015
Pubmed

Dynamic expression patterns of the pudgy/spondylocostal dysostosis gene Dll3 in the developing nervous system.

DLL1 NOTCH2 NOTCH4

1.09e-06983311118901
Pubmed

Notch1 signals through Jagged2 to regulate apoptosis in the apical ectodermal ridge of the developing limb bud.

DLL1 NOTCH2 NOTCH4

1.09e-06983316245338
Pubmed

Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins.

THBS1 FBN1 VWF MATN2 LAMA2 EDIL3

1.43e-0614683627068509
Pubmed

Spatiotemporal expression of Notch receptors and ligands in developing mouse placenta.

DLL1 NOTCH2 NOTCH4

1.55e-061083323665443
Pubmed

Comprehensive proteomic characterization of stem cell-derived extracellular matrices.

THBS1 FBN1 FBN2 EFEMP2 EDIL3

2.05e-068683528327460
Pubmed

A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway.

DLL1 NOTCH2 NOTCH4

2.13e-06118339187150
Pubmed

Coexpression of Cux-1 and Notch signaling pathway components during kidney development.

DLL1 NOTCH2 NOTCH4

2.13e-061183315499562
Pubmed

Localisation of members of the notch system and the differentiation of vibrissa hair follicles: receptors, ligands, and fringe modulators.

DLL1 NOTCH2 NOTCH4

2.13e-061183310878608
Pubmed

Notch-associated gene expression in embryonic and adult taste papillae and taste buds suggests a role in taste cell lineage decisions.

DLL1 NOTCH2 NOTCH4

2.13e-061183312866128
Pubmed

HNF1B controls proximal-intermediate nephron segment identity in vertebrates by regulating Notch signalling components and Irx1/2.

LRP2 DLL1 NOTCH2 PCSK9

2.58e-064083423362348
Pubmed

Developmental expression of the Notch signaling pathway genes during mouse preimplantation development.

DLL1 NOTCH2 NOTCH4

2.84e-061283315465494
Pubmed

Basic helix-loop-helix transcription factors regulate the neuroendocrine differentiation of fetal mouse pulmonary epithelium.

DLL1 NOTCH2 NOTCH4

2.84e-061283310952889
Pubmed

Vascular expression of Notch pathway receptors and ligands is restricted to arterial vessels.

DLL1 NOTCH2 NOTCH4

3.68e-061383311578869
Pubmed

Inhibition of notch1-dependent cardiomyogenesis leads to a dilated myopathy in the neonatal heart.

VWF NOTCH2 NOTCH4

3.68e-061383320558824
Pubmed

Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway.

DLL1 NOTCH2 NOTCH4

4.68e-061483314757642
Pubmed

Homo- and heterotypic fibrillin-1 and -2 interactions constitute the basis for the assembly of microfibrils.

FBN1 FBN2

5.63e-06283212399449
Pubmed

Fibrillin-1 and fibrillin-2 are essential for formation of thick oxytalan fibers in human nonpigmented ciliary epithelial cells in vitro.

FBN1 FBN2

5.63e-06283221851253
Pubmed

New Evidence Supporting the Role of FBN1 in the Development of Adolescent Idiopathic Scoliosis.

FBN1 FBN2

5.63e-06283230044367
Pubmed

Material and mechanical properties of bones deficient for fibrillin-1 or fibrillin-2 microfibrils.

FBN1 FBN2

5.63e-06283221440062
Pubmed

MAGP-2 has multiple binding regions on fibrillins and has covalent periodic association with fibrillin-containing microfibrils.

FBN1 FBN2

5.63e-06283215131124
Pubmed

Notch receptors and hematopoiesis.

NOTCH2 NOTCH4

5.63e-06283211532344
Pubmed

Activated Notch2 signaling inhibits differentiation of cerebellar granule neuron precursors by maintaining proliferation.

CNTN2 NOTCH2

5.63e-06283211545715
Pubmed

Microfibril structure masks fibrillin-2 in postnatal tissues.

FBN1 FBN2

5.63e-06283220404337
Pubmed

Fibroblast A20 governs fibrosis susceptibility and its repression by DREAM promotes fibrosis in multiple organs.

FBN1 TNFAIP3

5.63e-06283236289219
Pubmed

Fibrillln mutations in Marfan syndrome and related phenotypes.

FBN1 FBN2

5.63e-0628328791520
Pubmed

Fibrillin genes map to regions of conserved mouse/human synteny on mouse chromosomes 2 and 18.

FBN1 FBN2

5.63e-0628328307578
Pubmed

Developmental expression of fibrillin genes suggests heterogeneity of extracellular microfibrils.

FBN1 FBN2

5.63e-0628327744963
Pubmed

Fibrillin microfibrils in bone physiology.

FBN1 FBN2

5.63e-06283226408953
Pubmed

Arg-Gly-Asp-containing domains of fibrillins-1 and -2 distinctly regulate lung fibroblast migration.

FBN1 FBN2

5.63e-06283218006876
Pubmed

Rare variants in FBN1 and FBN2 are associated with severe adolescent idiopathic scoliosis.

FBN1 FBN2

5.63e-06283224833718
Pubmed

Role of thrombospondin-1 in control of von Willebrand factor multimer size in mice.

THBS1 VWF

5.63e-06283214981081
Pubmed

A20 protects endothelial cells from TNF-, Fas-, and NK-mediated cell death by inhibiting caspase 8 activation.

TNFAIP3 FAS

5.63e-06283215251990
Pubmed

Nonselective assembly of fibrillin 1 and fibrillin 2 in the rodent ocular zonule and in cultured cells: implications for Marfan syndrome.

FBN1 FBN2

5.63e-06283224265020
Pubmed

In vivo studies of mutant fibrillin-1 microfibrils.

FBN1 FBN2

5.63e-06283220529844
Pubmed

Fibrillin-1 mutations causing Weill-Marchesani syndrome and acromicric and geleophysic dysplasias disrupt heparan sulfate interactions.

FBN1 FBN2

5.63e-06283223133647
Pubmed

Proprotein convertase subtilisin/kexin type 9 targets megalin in the kidney proximal tubule and aggravates proteinuria in nephrotic syndrome.

LRP2 PCSK9

5.63e-06283237406929
Pubmed

Thrombospondin 1 requires von Willebrand factor to modulate arterial thrombosis in mice.

THBS1 VWF

5.63e-06283225343959
Pubmed

Linkage of Marfan syndrome and a phenotypically related disorder to two different fibrillin genes.

FBN1 FBN2

5.63e-0628321852206
Pubmed

Fibrillins can co-assemble in fibrils, but fibrillin fibril composition displays cell-specific differences.

FBN1 FBN2

5.63e-06283212429739
Pubmed

Relationship between thrombospondin gene variations, von Willebrand factor levels and the risk of coronary heart disease in an older population.

THBS1 VWF

5.63e-06283221518247
Pubmed

Notch ligation by Delta1 inhibits peripheral immune responses to transplantation antigens by a CD8+ cell-dependent mechanism.

DLL1 NOTCH2

5.63e-06283214660750
Pubmed

Thrombospondin-1 in von Willebrand factor function.

THBS1 VWF

5.63e-06283218855616
Pubmed

Fibrillin-1 and fibrillin-2 in human embryonic and early fetal development.

FBN1 FBN2

5.63e-06283212524050
Pubmed

Structure and expression of fibrillin-2, a novel microfibrillar component preferentially located in elastic matrices.

FBN1 FBN2

5.63e-0628328120105
Pubmed

The fibrillinopathies: New insights with focus on the paradigm of opposing phenotypes for both FBN1 and FBN2.

FBN1 FBN2

5.63e-06283235419902
Pubmed

Fibrillin assembly: dimer formation mediated by amino-terminal sequences.

FBN1 FBN2

5.63e-06283210504303
Pubmed

A novel secreted, cell-surface glycoprotein containing multiple epidermal growth factor-like repeats and one CUB domain is highly expressed in primary osteoblasts and bones.

SCUBE1 SCUBE3

5.63e-06283215234972
Pubmed

The anaphase-promoting complex protein 5 (AnapC5) associates with A20 and inhibits IL-17-mediated signal transduction.

TNFAIP3 ANAPC5

5.63e-06283223922952
Pubmed

Immunohistochemical expression of fibrillin-1 and fibrillin-2 during tooth development.

FBN1 FBN2

5.63e-06283225524144
Pubmed

The adaptor protein ARH escorts megalin to and through endosomes.

LDLRAP1 LRP2

5.63e-06283214528014
Pubmed

Can signal peptide-CUB-EGF domain-containing protein (SCUBE) levels be a marker of angiogenesis in patients with psoriasis?

SCUBE1 SCUBE3

5.63e-06283228238185
Pubmed

Scube regulates synovial angiogenesis-related signaling.

SCUBE2 SCUBE3

5.63e-06283224084593
Pubmed

notch2, notch4 gene polymorphisms in psoriasis vulgaris.

NOTCH2 NOTCH4

5.63e-06283223587900
Pubmed

Fibrillins 1 and 2 perform partially overlapping functions during aortic development.

FBN1 FBN2

5.63e-06283216407178
Pubmed

N-terminal domains of fibrillin 1 and fibrillin 2 direct the formation of homodimers: a possible first step in microfibril assembly.

FBN1 FBN2

5.63e-06283210359653
Pubmed

Inflammation dysregulates Notch signaling in endothelial cells: implication of Notch2 and Notch4 to endothelial dysfunction.

NOTCH2 NOTCH4

5.63e-06283220643108
Pubmed

Expression of Notch pathway genes in the embryonic mouse metanephros suggests a role in proximal tubule development.

DLL1 NOTCH2 NOTCH4

5.84e-061583312971992
Pubmed

Expression of Notch pathway components in fetal and adult mouse small intestine.

DLL1 NOTCH2 NOTCH4

7.18e-061683312617809
Pubmed

An essential role for Notch in neural crest during cardiovascular development and smooth muscle differentiation.

DLL1 NOTCH2 NOTCH4

7.18e-061683317273555
Pubmed

Requirement of Math1 for secretory cell lineage commitment in the mouse intestine.

DLL1 NOTCH2 NOTCH4

7.18e-061683311739954
Pubmed

Notch gene expression during pancreatic organogenesis.

DLL1 NOTCH2 NOTCH4

7.18e-061683310842072
Pubmed

Myh10 deficiency leads to defective extracellular matrix remodeling and pulmonary disease.

THBS1 FBN1 FBN2 EFEMP2

7.48e-065283430389913
Pubmed

Gamma-secretase activation of notch signaling regulates the balance of proximal and distal fates in progenitor cells of the developing lung.

DLL1 NOTCH2 NOTCH4

8.70e-061783318694942
Pubmed

Segmental expression of Notch and Hairy genes in nephrogenesis.

DLL1 NOTCH2 NOTCH4

8.70e-061783315821257
Pubmed

Unravelling differential Hes1 dynamics during axis elongation of mouse embryos through single-cell tracking.

DLL1 NOTCH2 NOTCH4

8.70e-061783339315665
Pubmed

Developmental coronary maturation is disturbed by aberrant cardiac vascular endothelial growth factor expression and Notch signalling.

DLL1 NOTCH2 NOTCH4

1.04e-051883318093989
Pubmed

SCUBE3 loss-of-function causes a recognizable recessive developmental disorder due to defective bone morphogenetic protein signaling.

SCUBE1 SCUBE2 SCUBE3

1.04e-051883333308444
Pubmed

PCSK9 reduces the protein levels of the LDL receptor in mouse brain during development and after ischemic stroke.

PCSK5 CNTN2 PCSK9

1.04e-051883321518694
Pubmed

RBPjkappa-dependent Notch function regulates Gata2 and is essential for the formation of intra-embryonic hematopoietic cells.

DLL1 NOTCH2 NOTCH4

1.04e-051883315689374
Pubmed

Notch 2 and Notch 1/3 segregate to neuronal and glial lineages of the developing olfactory epithelium.

DLL1 NOTCH2 NOTCH4

1.24e-051983316518823
Pubmed

HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.

TRPC4AP SYNE2 COPB2 GLYCTK MED14 DMBT1 FAS TIAM2 NOTCH4 ITPR1

1.26e-05754831035906200
Pubmed

Interaction of tropoelastin with the amino-terminal domains of fibrillin-1 and fibrillin-2 suggests a role for the fibrillins in elastic fiber assembly.

FBN1 FBN2

1.69e-05383210825173
Pubmed

The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: functional consequences of natural mutations and post-translational modifications.

PCSK5 PCSK9

1.69e-05383216912035
Pubmed

Association between variations in coagulation system genes and carotid plaque.

THBS1 VWF

1.69e-05383222982001
Pubmed

Adamts10 inactivation in mice leads to persistence of ocular microfibrils subsequent to reduced fibrillin-2 cleavage.

FBN1 FBN2

1.69e-05383230201140
Pubmed

ARH directs megalin to the endocytic recycling compartment to regulate its proteolysis and gene expression.

LDLRAP1 LRP2

1.69e-05383223836931
Pubmed

Thrombospondin-1 and ADAMTS13 competitively bind to VWF A2 and A3 domains in vitro.

THBS1 VWF

1.69e-05383220705333
Pubmed

Differential expression of Notch genes in human osteoblastic cells.

NOTCH2 NOTCH4

1.69e-05383211836628
Pubmed

Inhibition of the chondrocyte phenotype by retinoic acid involves upregulation of metalloprotease genes independent of TGF-beta.

ADAM7 ADAM5

1.69e-0538328163572
Pubmed

Notch signaling: cell fate control and signal integration in development.

NOTCH2 NOTCH4

1.69e-05383210221902
Pubmed

Requirement of biphasic calcium release from the endoplasmic reticulum for Fas-mediated apoptosis.

FAS ITPR1

1.69e-05383217130290
Pubmed

Fibrillin-1 and -2 differentially modulate endogenous TGF-β and BMP bioavailability during bone formation.

FBN1 FBN2

1.69e-05383220855508
InteractionNTN5 interactions

FRAS1 FBN1 FBN2 LRP2 NOTCH2 SORL1

4.11e-1024806int:NTN5
InteractionZFP41 interactions

FRAS1 FBN1 FBN2 LRP2 NOTCH2 SORL1

9.99e-0857806int:ZFP41
InteractionGREM2 interactions

BMP1 FBN2 LRP2 NOTCH2 SORL1

3.43e-0737805int:GREM2
InteractionIGFL3 interactions

PCSK5 FRAS1 FBN2 LRP2 NOTCH2 SORL1

5.24e-0775806int:IGFL3
InteractionSCUBE1 interactions

SCUBE1 SCUBE2 SCUBE3

5.99e-075803int:SCUBE1
InteractionPRG3 interactions

PCSK5 FRAS1 FBN2 NOTCH2 PCSK9

1.44e-0649805int:PRG3
InteractionPRG2 interactions

PCSK5 BMP1 THBS1 FRAS1 TRPC4AP FBN2 NOTCH2 PCSK9 SORL1

1.92e-06285809int:PRG2
InteractionMFAP5 interactions

TRPC4AP FBN1 FBN2 VWF DLL1

1.95e-0652805int:MFAP5
InteractionSCUBE3 interactions

SCUBE1 MATN2 SCUBE3

3.33e-068803int:SCUBE3
InteractionFBXO2 interactions

PCSK5 BMP1 FRAS1 FBN1 FBN2 SYNE2 LRP2 EDIL3 NOTCH2 SORL1

5.15e-064118010int:FBXO2
InteractionFBN2 interactions

THBS1 FBN1 FBN2 MATN2 NOTCH2

5.95e-0665805int:FBN2
InteractionCACNA1A interactions

PCSK5 VWF LLGL1 MATN2 EFEMP2 PPM1A

9.50e-06123806int:CACNA1A
InteractionNPNT interactions

MATN2 SCUBE3 NOTCH2

9.71e-0611803int:NPNT
InteractionCFC1 interactions

PCSK5 BMP1 THBS1 FRAS1 NOTCH2 SORL1

1.09e-05126806int:CFC1
InteractionPI15 interactions

PCSK5 BMP1 THBS1 PCSK9 SORL1

1.98e-0583805int:PI15
InteractionZNF408 interactions

FRAS1 FBN1 FBN2 LRP2 NOTCH2 SORL1

2.43e-05145806int:ZNF408
InteractionTIMP3 interactions

FRAS1 LRP2 NOTCH2 PPM1A SORL1

2.93e-0590805int:TIMP3
InteractionCCN6 interactions

FRAS1 NOTCH2 SORL1

5.58e-0519803int:CCN6
InteractionZNF224 interactions

FBN2 LRP2 SORL1

6.54e-0520803int:ZNF224
InteractionMAML3 interactions

ZBTB1 NOTCH2 NOTCH4

6.54e-0520803int:MAML3
InteractionTRADD interactions

PCSK5 TRPC4AP POLR1A TNFAIP3 FAS

8.72e-05113805int:TRADD
InteractionSCUBE2 interactions

SCUBE1 SCUBE2

9.29e-054802int:SCUBE2
InteractionLYZL1 interactions

BMP1 THBS1 FRAS1 PCSK9 SORL1

1.07e-04118805int:LYZL1
InteractionLYPD4 interactions

PCSK5 BMP1 THBS1 FBN2 PCSK9

1.30e-04123805int:LYPD4
InteractionZDHHC15 interactions

THBS1 FBN1 FBN2 LRP2 LAMA2

1.40e-04125805int:ZDHHC15
InteractionMKRN2 interactions

CNOT10 SYNE2 CTBP2 BCOR DLL1 FAS CASZ1 NOTCH2

1.44e-04385808int:MKRN2
InteractionCOL1A1 interactions

BMP1 THBS1 VWF MATN2 TNFAIP3

1.57e-04128805int:COL1A1
InteractionZNF517 interactions

MICAL1 LRP2 SORL1

2.04e-0429803int:ZNF517
InteractionMSTN interactions

BMP1 WFIKKN2 PCSK9

3.02e-0433803int:MSTN
InteractionNOTO interactions

LDLRAP1 GLYCTK EIPR1

3.02e-0433803int:NOTO
Cytoband10q24.1

FAS ZNF518A

7.29e-042283210q24.1
CytobandXq26.2

USP26 OR13H1

1.18e-0328832Xq26.2
Cytoband12p13.3

VWF CD163L1

1.36e-033083212p13.3
CytobandEnsembl 112 genes in cytogenetic band chr14q23

SYNE2 ZBTB1 PPM1A

1.73e-03130833chr14q23
CytobandXp11.4

MED14 BCOR

1.74e-0334832Xp11.4
Cytoband10q26.13

CTBP2 DMBT1

2.18e-033883210q26.13
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF502 ZNF569 ZNF558 ZNF398 ZBTB41 ZNF772 ZNF619 ZBTB1 CASZ1 ZNF879 ZNF518A ZNF646

6.91e-06718641228
GeneFamilyProprotein convertase subtilisin/kexin family

PCSK5 PCSK9

4.37e-049642973
CoexpressionNABA_ECM_GLYCOPROTEINS

THBS1 FRAS1 EYS FBN1 FBN2 VWF MATN2 EFEMP2 LAMA2 NTNG1 DMBT1 EDIL3

1.14e-121968212M3008
CoexpressionNABA_MATRISOME

PCSK5 BMP1 THBS1 FRAS1 EYS SCUBE1 FBN1 FBN2 VWF SCUBE2 TIMP4 MATN2 ADAM7 WFIKKN2 EFEMP2 SCUBE3 LAMA2 NTNG1 DMBT1 EDIL3 ANGPTL5

4.32e-1210268221M5889
CoexpressionNABA_ECM_GLYCOPROTEINS

THBS1 FRAS1 FBN1 FBN2 VWF MATN2 EFEMP2 LAMA2 NTNG1 DMBT1 EDIL3

2.06e-111918211MM17059
CoexpressionNABA_MATRISOME

PCSK5 BMP1 THBS1 FRAS1 SCUBE1 FBN1 FBN2 VWF SCUBE2 TIMP4 MATN2 ADAM7 ADAM5 WFIKKN2 EFEMP2 SCUBE3 LAMA2 NTNG1 DMBT1 EDIL3

2.69e-1110088220MM17056
CoexpressionHALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION

BMP1 THBS1 FBN1 FBN2 MATN2 EFEMP2 LAMA2 TNFAIP3 FAS EDIL3 NOTCH2

3.38e-112008211M5930
CoexpressionNABA_CORE_MATRISOME

THBS1 FRAS1 EYS FBN1 FBN2 VWF MATN2 EFEMP2 LAMA2 NTNG1 DMBT1 EDIL3

6.04e-112758212M5884
CoexpressionNABA_CORE_MATRISOME

THBS1 FRAS1 FBN1 FBN2 VWF MATN2 EFEMP2 LAMA2 NTNG1 DMBT1 EDIL3

8.29e-102708211MM17057
CoexpressionFUKUSHIMA_TNFSF11_TARGETS

DLL1 NOTCH2 NOTCH4

1.60e-0516823MM1296
CoexpressionFUKUSHIMA_TNFSF11_TARGETS

DLL1 NOTCH2 NOTCH4

1.60e-0516823M2207
CoexpressionWATANABE_ULCERATIVE_COLITIS_WITH_CANCER_UP

PCSK5 FBN1 EDIL3

2.76e-0519823M12084
CoexpressionGSE32423_CTRL_VS_IL7_IL4_MEMORY_CD8_TCELL_UP

LDLRAP1 MATN2 CTBP2 DLL1 ZBTB1 SORL1

3.96e-05200826M5087
CoexpressionSCHAEFFER_PROSTATE_DEVELOPMENT_48HR_DN

THBS1 MATN2 WFIKKN2 NTNG1 BCOR EDIL3 TIAM2 PPM1A

4.42e-05411828M1351
CoexpressionSCHAEFFER_PROSTATE_DEVELOPMENT_48HR_DN

THBS1 MATN2 WFIKKN2 NTNG1 BCOR EDIL3 TIAM2 PPM1A

4.81e-05416828MM1002
CoexpressionJEON_SMAD6_TARGETS_UP

THBS1 FBN1 FAS

5.70e-0524823M4592
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HNBML1

MICAL1 PTPN3 SCUBE1 EDIL3 PLPPR1 PHF21B CNTN2

7.67e-05328827M39064
CoexpressionGAUSSMANN_MLL_AF4_FUSION_TARGETS_G_UP

PTPN3 THBS1 FBN2 SCUBE2 TTC34 ZBTB1

1.21e-04245826M18095
CoexpressionSMID_BREAST_CANCER_LUMINAL_A_UP

PCSK5 SCUBE2 TIMP4 LAMA2

1.49e-0485824M7517
CoexpressionAtlasdev gonad_e13.5_M_InterstitTestis_Sma_top-relative-expression-ranked_1000

PCSK5 THBS1 FRAS1 SCUBE1 FBN1 FBN2 MATN2 EFEMP2 ZNF558 LAMA2 NTNG1 NOTCH2

3.25e-057778012gudmap_dev gonad_e13.5_M_InterstitTestis_Sma_1000
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_1000

LDLRAP1 SCUBE1 SCUBE2 SYNE2 GLYCTK MED14 LRP2 SCUBE3 LRRTM1 DLL1 ANAPC5 PHF21B ZNF518A

7.78e-059898013Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_1000
CoexpressionAtlasfacebase_RNAseq_e14.5_palate_poster_oral_Tgfbr2_WT_2500_K4

PCSK5 BMP1 MICAL1 THBS1 FBN1 FBN2 VWF MATN2 EFEMP2 LAMA2 TRIOBP NTNG1 PHF21B SORL1

8.93e-0511488014facebase_RNAseq_e14.5_palate_poster_oral_Tgfbr2_WT_2500_K4
CoexpressionAtlasdev gonad_e13.5_M_InterstitTestis_Sma_k-means-cluster#1_top-relative-expression-ranked_1000

THBS1 FRAS1 SCUBE1 FBN2 MATN2 ZNF558

1.06e-04199806gudmap_dev gonad_e13.5_M_InterstitTestis_Sma_k1_1000
CoexpressionAtlasdev gonad_e13.5_M_InterstitFLeydig_MafB_k-means-cluster#1_top-relative-expression-ranked_1000

SCUBE1 FBN2 MATN2 SYNE2 ZNF558

1.10e-04125805gudmap_dev gonad_e13.5_M_InterstitFLeydig_MafB_k1_1000
CoexpressionAtlasFacebaseRNAseq_e8.5_Hind Brain Neural Epithelium_top-relative-expression-ranked_2500_k-means-cluster#5

SCUBE1 GLYCTK LRP2 BCOR DLL1 PHF21B

1.25e-04205806Facebase_RNAseq_e8.5_Hind Brain Neural Epithelium_2500_K5
CoexpressionAtlasdev gonad_e13.5_M_InterstitFLeydig_MafB_top-relative-expression-ranked_1000

SCUBE1 FBN1 FBN2 MATN2 SYNE2 EFEMP2 ZNF558 LAMA2 NTNG1 ZBTB41 NOTCH2

1.47e-047738011gudmap_dev gonad_e13.5_M_InterstitFLeydig_MafB_1000
CoexpressionAtlasdev gonad_e12.5_M_InterstitLeydig_MafB_k-means-cluster#1_top-relative-expression-ranked_1000

PCSK5 FBN1 FBN2 SYNE2 EFEMP2 ZNF558 LAMA2

1.69e-04310807gudmap_dev gonad_e12.5_M_InterstitLeydig_MafB_k1_1000
CoexpressionAtlasgudmap_RNAseq_e15.5_Podocytes_2500_K3

SCUBE2 SCUBE3 NTNG1 DLL1

1.95e-0476804gudmap_RNAseq_e15.5_Podocytes_2500_K3
ToppCelldroplet-Limb_Muscle-MUSCLE-1m-Mesenchymal|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 BMP1 FBN1 SCUBE2 MATN2 EFEMP2 LAMA2

8.99e-08198837b086af292a508a156266c2d899ba1caf820bf61c
ToppCelldroplet-Limb_Muscle-MUSCLE-1m-Mesenchymal-mesenchymal_stem_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 BMP1 FBN1 SCUBE2 MATN2 EFEMP2 LAMA2

8.99e-081988371b90d632e59c3c47b936e829cceeb0334f05f34f
ToppCelldroplet-Kidney-KIDNEY-1m-Mesenchymal-Stroma____fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN1 FBN2 MATN2 ADAM5 EFEMP2 LAMA2

1.29e-06185836785c55d39909fac74415f24427979691e7e694e6
ToppCelldroplet-Kidney-KIDNEY-1m-Mesenchymal|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN1 FBN2 MATN2 ADAM5 EFEMP2 LAMA2

1.29e-0618583697a1dcacbc48dc3f41c26fbb59af35c935f894d4
ToppCelldroplet-Kidney-KIDNEY-1m-Mesenchymal-fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN1 FBN2 MATN2 ADAM5 EFEMP2 LAMA2

1.33e-0618683694d577dbb6bfacf50632e1fe8af041b35a1e6b23
ToppCellfacs-GAT-Fat-3m-Mesenchymal-mesenchymal_progenitor|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 BMP1 FBN1 MATN2 EFEMP2 LAMA2

1.76e-0619583669a29d03e664b72f32d41876510c62345c3aed31
ToppCellfacs-GAT-Fat-3m-Mesenchymal|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 BMP1 FBN1 MATN2 EFEMP2 LAMA2

1.76e-061958361cffae2b08dbfa1c633ce24023e89b66d28b5431
ToppCellfacs-GAT-Fat-3m-Mesenchymal-mesenchymal_stem_cell_of_adipose|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 BMP1 FBN1 MATN2 EFEMP2 LAMA2

1.76e-061958369cef6f18664518060af7c192310dddce6d70345a
ToppCellTracheal-10x5prime-Stromal-Peri/Epineurial_|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

SCUBE1 FBN1 FBN2 MATN2 SCUBE3 LAMA2

1.86e-061978362cb1f557ce1400398975de94638126b4522567f3
ToppCell(2)_Fibroblasts-(22)_Fibro-3|(2)_Fibroblasts / Cell class and subclass of bone marrow stroma cells in homeostatis

PCSK5 FBN2 SCUBE2 LAMA2 NTNG1 EDIL3

1.86e-06197836d9021bab82403e566ec10f78acb227c0f80b88fe
ToppCell3'-GW_trimst-1-SmallIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FBN2 EFEMP2 SCUBE3 LRRTM1 DLL1 EDIL3

1.92e-061988364a4566f86c9365a41b4cfd1609eac09bd73b3f34
ToppCell3'-GW_trimst-1-SmallIntestine-Mesenchymal-fibroblastic|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FBN1 FBN2 MATN2 EFEMP2 DLL1 EDIL3

1.97e-0619983630ab0750d51f168b18c434c974d24a4e70f29cc7
ToppCell5'-GW_trimst-2-SmallIntestine-Mesenchymal-fibroblastic|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FBN1 FBN2 SCUBE2 EFEMP2 DLL1 EDIL3

1.97e-06199836e78f661b40da34768469549b6e755d330be6bbd8
ToppCellfacs-Trachea-nan-3m-Mesenchymal|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BMP1 FBN1 MATN2 EFEMP2 COPB2 LAMA2

1.97e-0619983667f78c070c56e44fba36542041bf7fa1c291807c
ToppCellfacs-Trachea-nan-3m-Mesenchymal-nan|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BMP1 FBN1 MATN2 EFEMP2 COPB2 LAMA2

1.97e-061998361ae244b563f85c1ee8d22698f478c842a4d9c7f5
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L5_PT|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PCSK5 NTNG1 CTBP2 CASZ1 TIAM2

6.49e-061408357cc891d676555609add6fc7880735d948a2ad801
ToppCellfacs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

USP26 FRAS1 ADAM7 DMBT1 PDE11A

1.32e-05162835bf886e22ff2a20353499004b53f25fb9e6574896
ToppCell15-Airway-Mesenchymal-Airway_Smooth_Muscle|Airway / Age, Tissue, Lineage and Cell class

USP26 SCUBE1 WFIKKN2 LRRTM1 CASZ1

1.44e-05165835531804467601e1ee1f771cffa21501f6d464ae10
ToppCell5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FBN1 FBN2 MATN2 LAMA2 EDIL3

1.61e-05169835c0824a93674e2bff0f09b2d2fab5bab016a2e379
ToppCellLymphoid-Lymphoid-T_cells_(Cd8+_T_cell)|Lymphoid / shred on cell class and cell subclass (v4)

IBTK CD163L1 MATN2 CTBP2 TNFAIP3

1.66e-0517083520fd1a312c81c1bf3c5d2d6caf9b578e6b7a4171
ToppCellILEUM-inflamed-(9)_Enteric_neurons|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

TIMP4 MATN2 WFIKKN2 LRRTM1 PLPPR1

2.07e-05178835d9142151819afb0dc22bfb32a9c9dba5f553067d
ToppCellILEUM-inflamed-(9)_Neuro_cell|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

TIMP4 MATN2 WFIKKN2 LRRTM1 PLPPR1

2.07e-05178835611504b0a9e6318b18fba83787b03f9245c82252
ToppCellP03-Mesenchymal-mesenchymal_fibroblast-mesenchymal_alveolar_niche_cell|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

FBN1 FBN2 RTL3 MATN2 LAMA2

2.56e-05186835c0a036096c2cb23305605b8aaf18869d6e0fb512
ToppCell10x5'v1-week_14-16-Mesenchymal_osteo-stroma-chondrocyte|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

MATN2 SCUBE3 LRRTM1 EDIL3 ANGPTL5

2.56e-0518683580a0a42ca8585cdb1dda57a18c254316a126ee64
ToppCelldroplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN1 FBN2 RTL3 LRP2 LAMA2

2.62e-051878354e553721fa5598cb211f44e3226280b7e6885484
ToppCelldroplet-Pancreas-Exocrine-18m-Mesenchymal|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN1 FBN2 RTL3 LRP2 LAMA2

2.62e-05187835d36e7fc6125e7a4310499365022d38f34b757a73
ToppCelldroplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN1 FBN2 RTL3 LRP2 LAMA2

2.62e-05187835827eae63fabf6892a82ce7779b5f395958d3d628
ToppCelldroplet-Kidney-nan-18m-Epithelial-Pecam____Kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 FBN1 VWF TIMP4 NOTCH4

2.62e-05187835e93cad16a087d1443cbf4e1690dc1b35d7a84c41
ToppCelldroplet-Lung-LUNG-1m-Mesenchymal-adventitial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BMP1 FBN1 RTL3 MATN2 LAMA2

2.76e-05189835f0a2d4ef9896d764971ebbc6952510c128bb76e8
ToppCellLPS-IL1RA+antiTNF-Endothelial-Endothelial-Artery|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FBN1 VWF TTC34 TIAM2 NOTCH4

2.76e-05189835c45734970036e6d28d5e3fe7c9458fae38a3f624
ToppCell10x5'v1-week_14-16-Mesenchymal_fibro-stroma|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

FBN1 RTL3 MATN2 LAMA2 CNTN2

2.76e-05189835eccf3d49354a67c94f1ed7c15a98a48a5e8e2ed0
ToppCelldroplet-Lung-LUNG-1m-Mesenchymal-Adventitial_Fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BMP1 FBN1 RTL3 MATN2 LAMA2

2.76e-05189835378f26f751ab4b470948c35dd8347de72dd12ff7
ToppCellLPS_only-Endothelial-Endothelial-Artery|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PCSK5 FBN1 VWF TTC34 NOTCH4

2.76e-05189835b028466fcd36fdeceec752e55a24286a1cd62ae4
ToppCell10x5'v1-week_14-16-Mesenchymal_fibro|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

FBN1 RTL3 MATN2 LAMA2 CNTN2

2.76e-0518983540764f461b8aa1d3a2c5a30590b7fb9307d47d09
ToppCellE18.5-samps-Mesenchymal|E18.5-samps / Age Group, Lineage, Cell class and subclass

THBS1 FBN1 EFEMP2 LAMA2 NOTCH2

2.76e-051898350c18d3de4720759cf802eefb4d0ddde2a9246a1a
ToppCellPND01-Endothelial-Endothelial_blood-vessel-Macrovascular_EC|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

VWF DLL1 FAS CASZ1 NOTCH4

2.76e-051898351e1afa66b32ae752c0a42b02b80f10205464569c
ToppCell(2)_Fibroblasts-(22)_Fibro-3|World / Cell class and subclass of bone marrow stroma cells in homeostatis

PCSK5 FBN2 SCUBE2 LAMA2 NTNG1

2.83e-051908353aed03b87ba2c8d479048c3ceef3ff5e38746c28
ToppCellPND07-28-samps-Mesenchymal-Myofibroblast|PND07-28-samps / Age Group, Lineage, Cell class and subclass

BMP1 THBS1 FBN1 EFEMP2 LAMA2

2.90e-051918359bbafdf316c1fa3a9f1ee30d41dd7158b5c97279
ToppCell10x5'v1-week_14-16-Mesenchymal_fibro-stroma-arteriolar_fibroblast|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

FBN1 RTL3 MATN2 LAMA2 CNTN2

2.90e-051918355271198116343c07202649889057e5774d7fdde3
ToppCellE18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FBN1 FBN2 RTL3 MATN2 LAMA2

2.90e-051918354b50fdd310701251e64e16cd2d07ce03dbfd3e3e
ToppCellE18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FBN1 FBN2 RTL3 MATN2 LAMA2

2.90e-0519183575d2197076a9dfc868e8baf95bd4c5e44f438e3e
ToppCellLPS-antiTNF-Endothelial-Endothelial-Artery|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PCSK5 FBN1 VWF TIAM2 NOTCH4

2.90e-051918354b3d5157344dbfbf4fab518611cd9fa37fac7bd9
ToppCellfacs-Heart-LV-3m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BMP1 THBS1 FBN1 MATN2 LAMA2

2.98e-05192835671d4e1eee5aba03c43dbc98f4b51ce42b3df5d5
ToppCellPND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FBN1 FBN2 RTL3 MATN2 LAMA2

2.98e-05192835ad48c941a3ddfd9a5146bafc2209da577bb50531
ToppCellCOVID-19-Heart-Fib_+_EC_+_Pericyte|Heart / Disease (COVID-19 only), tissue and cell type

PCSK5 FBN1 VWF LAMA2 ITPR1

2.98e-0519283560b1312e84f6d6448365a952469c506c00b5fe93
ToppCellfacs-Heart-LV-3m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BMP1 THBS1 FBN1 MATN2 LAMA2

2.98e-05192835840a34c1b82d218be999ab5e1bcafd6370d7a4b1
ToppCellPND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FBN1 FBN2 RTL3 MATN2 LAMA2

2.98e-0519283519b94f254d51b9bda3d9b7c6f85e27ecb58409c8
ToppCellfacs-Large_Intestine-Distal-3m-Epithelial-Reg4/cKit+_deep_crypt_secretory_cells_(Distal)|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MICAL1 THBS1 DLL1 PCSK9 ITPR1

3.05e-051938354aee372ba2c0351b0221d0d468707d1ad21526d6
ToppCelldroplet-Limb_Muscle-nan-18m-Mesenchymal|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BMP1 THBS1 FBN1 EFEMP2 LAMA2

3.05e-0519383549600db68ed65cafc67bd45a285b364e4f5f88af
ToppCellfacs-MAT-Fat-3m-Mesenchymal-mesenchymal_stem_cell_of_adipose|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 BMP1 FBN1 MATN2 LAMA2

3.05e-05193835f95b95c58a6edb8a03dd15ae166f47f9f33d8bd6
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PTPN3 FRAS1 LRP2 PLPPR1 CASZ1

3.05e-0519383582e8a4c40299ffcdfd5a0da711bb9de6fb8a2eaa
ToppCelldroplet-Lung-nan-18m-Endothelial|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF DLL1 FAS CASZ1 NOTCH4

3.05e-051938352f387fb763448b7c351da19a55765375e782c790
ToppCellfacs-Large_Intestine-Distal-3m-Epithelial-secretory_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MICAL1 THBS1 DLL1 PCSK9 ITPR1

3.05e-05193835aaa5042388dc451bff384c6bb237348f08280a08
ToppCellfacs-MAT-Fat-3m-Mesenchymal-mesenchymal_progenitor|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 BMP1 FBN1 MATN2 LAMA2

3.05e-0519383585faf6c5ce4769615a4eca036e2ba307e176bb52
ToppCelldroplet-Limb_Muscle-nan-18m-Mesenchymal-mesenchymal_stem_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BMP1 THBS1 FBN1 EFEMP2 LAMA2

3.05e-0519383545b5cab4dfeb0ed3b13631db5963740a792b810f
ToppCellfacs-MAT-Fat-3m-Mesenchymal|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 BMP1 FBN1 MATN2 LAMA2

3.05e-05193835110a7d2ba7d066c2be38be98b643b76c520dd980
ToppCellfacs-BAT-Fat-3m-Mesenchymal-mesenchymal_progenitor|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 BMP1 FBN1 EFEMP2 LAMA2

3.13e-05194835da45811ba07d746e7cba7ed78882b5d98ac7397d
ToppCellfacs-BAT-Fat-3m-Mesenchymal|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 BMP1 FBN1 EFEMP2 LAMA2

3.13e-0519483576b8512fd92014b3ecc42b0a20d6d1df074cba2c
ToppCelldroplet-Lung-nan-18m-Endothelial-Capillary_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF DLL1 FAS CASZ1 NOTCH4

3.13e-05194835faaa7f18667e8943528fd0e92b7988e5b0607b54
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

THBS1 FBN2 SYNE2 LRP2 EDIL3

3.13e-051948358ddcaaf24cee6e30d5be52c0cbf778cfba309c53
ToppCellfacs-BAT-Fat-3m-Mesenchymal-mesenchymal_stem_cell_of_adipose|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 BMP1 FBN1 EFEMP2 LAMA2

3.13e-05194835ef0fa9daecd3bf43c6cf56345928cacdbee19779
ToppCellfacs-Lung-3m|Lung / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

BMP1 THBS1 FBN1 LAMA2 NOTCH2

3.21e-05195835c4648c0332c3826776f9ad3f5f803dbac2b4c0c0
ToppCell15-Trachea-Mesenchymal|Trachea / Age, Tissue, Lineage and Cell class

BMP1 FBN1 MATN2 WFIKKN2 EFEMP2

3.29e-051968357e178c76285e61c721c38d7a995ebf89dc428f9f
ToppCellfacs-Bladder-nan-3m|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BMP1 IBTK TRPC4AP COPB2 NOTCH2

3.29e-0519683544f5b1b474399c9316729155f2ea95a82ca66e30
ToppCelldroplet-Heart-HEART-1m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BMP1 FBN1 MATN2 EFEMP2 LAMA2

3.29e-0519683559b5b5a0c123d0423abd19c312514849004b903b
ToppCellfacs-Lung-nan|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BMP1 THBS1 FBN1 MATN2 LAMA2

3.29e-05196835b05f77f3990b662682ffeaf0e4c2fb190e0a6e65
ToppCellfacs-Lung-nan-3m|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BMP1 THBS1 FBN1 MATN2 LAMA2

3.29e-05196835787c6cd92035e0b1108c2c086c42a229016e476b
ToppCellfacs-Bladder-nan-3m-Epithelial|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BMP1 IBTK TRPC4AP COPB2 NOTCH2

3.29e-05196835c0e90d964baa2eb4fbd18a52379ccec5d3bf59a8
ToppCelldroplet-Heart-HEART-1m-Mesenchymal-fibroblast|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BMP1 FBN1 MATN2 EFEMP2 LAMA2

3.37e-05197835b16add329bb35a558287ede51353010dde5bc029
ToppCell5'-GW_trimst-1.5-SmallIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FBN2 SCUBE3 LRRTM1 DLL1 EDIL3

3.37e-051978352e3d64648a1e4f01b9256a96b94b8a640ee1824c
ToppCell5'-GW_trimst-2-SmallIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FBN2 SCUBE3 LRRTM1 DLL1 EDIL3

3.37e-051978351da8ba5bbab232add6e43ad78b15c2339d0c2bc3
ToppCell10x3'2.3-week_17-19-Mesenchymal_adipo|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

PCSK5 SCUBE1 FBN1 TIMP4 EFEMP2

3.37e-051978355afddde4e2b5cd55abe11e9b9efae02dbdc3da3a
ToppCell10x3'2.3-week_17-19-Mesenchymal_adipo-stroma-adipo-CAR|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

PCSK5 SCUBE1 FBN1 TIMP4 EFEMP2

3.37e-051978351baffd087ca194a7355fefbb3bf67befb14fe2de
ToppCell10x3'2.3-week_17-19-Mesenchymal_adipo-stroma|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

PCSK5 SCUBE1 FBN1 TIMP4 EFEMP2

3.37e-05197835b9745e382baa2725dfcae060701fb53f6c8a31fa
ToppCellFibroblasts-DKK3+_Fibroblasts|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

FBN1 MATN2 LAMA2 EDIL3 ANGPTL5

3.45e-051988354f4632f26a2043c5e4ab89031b4229b5dca1bd48
ToppCellfacs-Trachea-nan-3m-Mesenchymal-fibroblast|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 BMP1 FBN1 MATN2 LAMA2

3.45e-051988350dc7d59a07428a7b7e8bdc81f0e2417dd4ce3cf2
ToppCellCOVID-19-lung-Fibroblast|lung / Disease (COVID-19 only), tissue and cell type

THBS1 FRAS1 FBN1 LAMA2 NTNG1

3.45e-05198835df3de77216f5c5d6141ec44d01c56b942f611838
ToppCelldroplet-Limb_Muscle-MUSCLE-1m-Mesenchymal-chondrocyte-like|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 FBN2 SCUBE2 MATN2 EFEMP2

3.45e-05198835524305c5d7b1d53e86ec0af775efefa3e0955e47
ToppCellTracheal-10x5prime-Stromal-Peri/Epineurial_-NAF_endoneurial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

FBN1 FBN2 MATN2 SCUBE3 LAMA2

3.45e-051988357a0c4dbc8c99968d42af00a718f4fedc544599ec
ToppCellTracheal-10x5prime-Stromal-Peri/Epineurial_-NAF_epineurial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

SCUBE1 MATN2 SCUBE3 HHIPL1 PCSK9

3.53e-05199835fbec5c034576cb1adaf05f6f97cc5525d19e0c1b
ToppCellwk_15-18-Mesenchymal-Fibroblast-Adventitial_fibro|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

THBS1 FBN1 FBN2 MATN2 EFEMP2

3.53e-051998358de6d7b2067b22cb9b5f01aa56a3803aebc4406d
ToppCelldistal-3-mesenchymal-Myofibroblast|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

FBN1 RTL3 MATN2 EFEMP2 LAMA2

3.53e-051998351f20addc0d138fec02ed6ca4c518169c568de263
ToppCell3'-GW_trimst-1.5-SmallIntestine-Mesenchymal-fibroblastic|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FBN2 EFEMP2 SCUBE3 DLL1 EDIL3

3.53e-05199835137ff58897e6ada8a5a70205f66fe9110795506b
ToppCellwk_20-22-Mesenchymal-Fibroblast-Adventitial_fibro|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

BMP1 FBN1 RTL3 MATN2 EFEMP2

3.53e-05199835ab0589c068c24aa989bdca083504fbad0c15221d
ToppCellLPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

THBS1 FBN1 SCUBE2 EFEMP2 NTNG1

3.62e-052008359b0916d8d07ac2bf1739f7be5296bf77ffee6094
ToppCellBronchial-NucSeq-Stromal-Fibroblastic-Fibro_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

THBS1 FRAS1 FBN1 LAMA2 NTNG1

3.62e-05200835e8462395fee0a532d1e7ec7f1795f28c42af6541
ToppCell367C-Fibroblasts-Fibroblast-B_(Myofibroblast)-|367C / Donor, Lineage, Cell class and subclass (all cells)

BMP1 FBN1 EFEMP2 LAMA2 EDIL3

3.62e-05200835082e718c1da3f4fdd33a001d15ad3ddb2be985c7
ToppCellControl_saline-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast|Control_saline / Treatment groups by lineage, cell group, cell type

PCSK5 THBS1 FBN1 MATN2 EFEMP2

3.62e-05200835a799fc7bb83ad0524362cb5010df949741fb7bf3
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-Artery|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

PCSK5 FBN1 VWF SYNE2 TIAM2

3.62e-0520083577ae679c35d3b9e2b620f34129f3a8d47e922c65
ToppCelldistal-1-mesenchymal-Adventitial_Fibroblast|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

FBN1 MATN2 EFEMP2 LAMA2 ANGPTL5

3.62e-05200835738060ed65fa5473fdb39e686f7cdecc059ed92c
ToppCellControl_saline-Endothelial-Endothelial-Artery|Control_saline / Treatment groups by lineage, cell group, cell type

PCSK5 FBN1 VWF SYNE2 TIAM2

3.62e-0520083565b71f1e8da5c3750fcd0a2e66d9ef3125a3f78a
ToppCell367C-Fibroblasts-Fibroblast-B_(Myofibroblast)|367C / Donor, Lineage, Cell class and subclass (all cells)

BMP1 FBN1 EFEMP2 LAMA2 EDIL3

3.62e-05200835731e55070a7ff315091855bd88cda30e5a7e1a98
ToppCell3'-GW_trimst-1-SmallIntestine-Mesenchymal-immature_mesenchymal_cell|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FBN1 FBN2 SYNE2 EFEMP2 PDE11A

3.62e-052008353dacd0afe69bc16bb33336ea9ea99a9cd47731d9
ToppCellTracheal-10x5prime-Stromal-Fibroblastic-Fibro_adventitial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

PCSK5 BMP1 FBN1 EFEMP2 LAMA2

3.62e-0520083574ad0ae592252060ee294d7483327d765a6ba1dd
ToppCell(5)_Fibroblast-E|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

FBN1 MATN2 EFEMP2 LAMA2 ANGPTL5

3.62e-0520083575e5ecb05e965e24d569aa2ef5cdf740b1528c06
ToppCellParenchymal-NucSeq-Stromal-Fibroblastic-Fibro_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

THBS1 FRAS1 FBN1 LAMA2 NTNG1

3.62e-0520083534f52003988ce6329d8deeee1ab875fa77e01e9d
ToppCellTracheal-10x5prime-Stromal-Fibroblastic|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

PCSK5 BMP1 FBN1 EFEMP2 LAMA2

3.62e-052008357ba292c30d915e66ebc8026fa76492cedf64700e
ToppCellLPS_anti-TNF-Endothelial-Endothelial-Artery|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

PCSK5 FBN1 VWF SYNE2 TIAM2

3.62e-05200835b1ff8d61b567f85006d6d20093f9c803b6d34674
ToppCell3'-GW_trimst-1-SmallIntestine-Mesenchymal-immature_mesenchymal_cell-Mesoderm_2_(ZEB2+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FBN1 FBN2 SYNE2 EFEMP2 PDE11A

3.62e-05200835ac8a5d71acd4d401995babd233f0d3738e8ad2a5
ToppCellControl_saline-Mesenchymal_myocytic-Pericyte-Pericyte_2|Control_saline / Treatment groups by lineage, cell group, cell type

FBN2 MATN2 LAMA2 EDIL3 NOTCH2

3.62e-05200835bc8949eb34482aca166c4602ff6ab876cb4c2c3c
ComputationalMetal / Ca ion binding.

BMP1 FBN1 FBN2 EFEMP2 TNFAIP3

1.10e-04133395MODULE_324
ComputationalAdhesion molecules.

FBN1 FBN2 VWF EFEMP2 LAMA2

1.45e-04141395MODULE_122
DrugEtofylline [519-37-9]; Up 200; 17.8uM; MCF7; HT_HG-U133A

BMP1 FRAS1 EFEMP2 LRP2 TNFAIP3 PLPPR1 ITPR1

8.03e-061988372256_UP
DrugSulfamerazine [127-79-7]; Up 200; 15.2uM; MCF7; HT_HG-U133A

MICAL1 FRAS1 EFEMP2 LAMA2 DGKQ PDE11A ZNF646

8.03e-061988376036_UP
DiseaseMalignant neoplasm of breast

BMP1 MICAL1 THBS1 VWF LLGL1 ZNF569 SYNE2 MCF2L2 MED14 OSBPL11 LAMA2 DLL1 ANAPC5 NOTCH2 NOTCH4 SORL1 ZNF646

4.36e-0910748117C0006142
Diseaseaortic aneurysm (is_implicated_in)

FBN1 EFEMP2

2.23e-053812DOID:3627 (is_implicated_in)
Diseaseconnective tissue disease (implicated_via_orthology)

FBN1 FBN2

2.23e-053812DOID:65 (implicated_via_orthology)
Diseasescoliosis (is_implicated_in)

FBN1 FBN2

4.45e-054812DOID:0060249 (is_implicated_in)
Diseaseresponse to platinum based chemotherapy, cytotoxicity measurement

FRAS1 EYS

7.40e-055812EFO_0004647, EFO_0006952
DiseaseCongenital muscular dystrophy (disorder)

SYNE2 LAMA2

1.11e-046812C0699743
Diseaseretinal detachment, retinal break

FRAS1 EFEMP2 LAMA2

1.22e-0435813EFO_0005773, EFO_0010698
Diseaseendometrial cancer (is_marker_for)

TIMP4 EFEMP2 NOTCH4

1.22e-0435813DOID:1380 (is_marker_for)
Diseaseglycosyl ceramide (d18:1/20:0, d16:1/22:0) measurement

SYNE2 PCSK9

1.55e-047812EFO_0800551
Diseasepalmitoyl dihydrosphingomyelin (d18:0/16:0) measurement

SYNE2 PCSK9

1.55e-047812EFO_0800400
DiseaseLymphoma

TNFAIP3 FAS NOTCH2

1.83e-0440813C0024299
DiseaseAutoimmune Lymphoproliferative Syndrome

TNFAIP3 FAS

2.06e-048812C1328840
Diseasemesangial proliferative glomerulonephritis (biomarker_via_orthology)

FBN1 VWF

2.06e-048812DOID:4783 (biomarker_via_orthology)
DiseaseFamilial hypercholesterolemia

LDLRAP1 PCSK9

2.06e-048812cv:C0020445
Diseasecomplement factor H-related protein 5 measurement

ADAM5 ZBTB41 SORL1

2.12e-0442813EFO_0008098
Diseaseneuropathic pain

BMP1 EYS TTC34

2.96e-0447813EFO_0005762
DiseaseFamilial thoracic aortic aneurysm and aortic dissection

FBN1 FBN2 EFEMP2

4.23e-0453813C4707243
DiseaseFEV/FEC ratio

PCSK5 FRAS1 FBN1 XKR9 SYNE2 SCUBE3 HHIPL1 DMBT1 CNTN2 ITPR1 SORL1

5.20e-0412288111EFO_0004713
DiseaseSjogren's Syndrome

DGKQ TNFAIP3

5.69e-0413812C1527336
DiseaseSicca Syndrome

DGKQ TNFAIP3

5.69e-0413812C0086981
DiseaseProteinuria

VWF LRP2

7.64e-0415812HP_0000093
DiseaseParoxysmal atrial fibrillation

VWF SYNE2 CASZ1 SORL1

9.12e-04156814C0235480
Diseasefamilial atrial fibrillation

VWF SYNE2 CASZ1 SORL1

9.12e-04156814C3468561
DiseasePersistent atrial fibrillation

VWF SYNE2 CASZ1 SORL1

9.12e-04156814C2585653
DiseaseSjogren's syndrome (implicated_via_orthology)

THBS1 FAS

9.85e-0417812DOID:12894 (implicated_via_orthology)
DiseaseAtrial Fibrillation

VWF SYNE2 CASZ1 SORL1

1.00e-03160814C0004238
Diseasepentachlorophenol measurement

EYS NTNG1 PLPPR1

1.08e-0373813EFO_0022071
Diseaseparathion measurement

EYS NTNG1 PLPPR1

1.08e-0373813EFO_0022070
Diseasepotassium chromate measurement

EYS NTNG1 PLPPR1

1.08e-0373813EFO_0022072
Diseasemercuric chloride measurement

EYS NTNG1 PLPPR1

1.08e-0373813EFO_0022068
Diseaseheptachlor epoxide measurement

EYS NTNG1 PLPPR1

1.08e-0373813EFO_0022067
Diseasemethoxychlor measurement

EYS NTNG1 PLPPR1

1.08e-0373813EFO_0022069
Disease4,6-dinitro-o-cresol measurement

EYS NTNG1 PLPPR1

1.08e-0373813EFO_0022053
Disease2,4,5-trichlorophenol measurement

EYS NTNG1 PLPPR1

1.08e-0373813EFO_0022052
Diseaseazinphos methyl measurement

EYS NTNG1 PLPPR1

1.08e-0373813EFO_0022055
Diseasealdrin measurement

EYS NTNG1 PLPPR1

1.08e-0373813EFO_0022054
Diseasedicofol measurement

EYS NTNG1 PLPPR1

1.08e-0373813EFO_0022060
Diseasedisulfoton measurement

EYS NTNG1 PLPPR1

1.08e-0373813EFO_0022062
Diseasedieldrin measurement

EYS NTNG1 PLPPR1

1.08e-0373813EFO_0022061
Diseaseendrin measurement

EYS NTNG1 PLPPR1

1.08e-0373813EFO_0022064
Diseaseendosulfan measurement

EYS NTNG1 PLPPR1

1.08e-0373813EFO_0022063
Diseaseheptachlor measurement

EYS NTNG1 PLPPR1

1.08e-0373813EFO_0022066
Diseaseethion measurement

EYS NTNG1 PLPPR1

1.08e-0373813EFO_0022065
Diseasechlorpyrifos measurement

EYS NTNG1 PLPPR1

1.08e-0373813EFO_0022057
Diseasecadmium chloride measurement

EYS NTNG1 PLPPR1

1.08e-0373813EFO_0022056
Diseasediazinon measurement

EYS NTNG1 PLPPR1

1.08e-0373813EFO_0022059
Diseasedibutyl phthalate measurement

EYS NTNG1 PLPPR1

1.08e-0373813EFO_0022058
Diseaseenvironmental exposure measurement

EYS NTNG1 PLPPR1

1.08e-0373813EFO_0008360
DiseaseHypercholesterolemia, Familial

LDLRAP1 PCSK9

1.11e-0318812C0020445
DiseaseDDT metabolite measurement

EYS NTNG1 PLPPR1

1.12e-0374813EFO_0007886
Diseasecoagulation factor measurement

VWF ZBTB41

1.37e-0320812EFO_0004634
Diseaseattempted suicide

PCSK5 FBN1 SCUBE2 LRP2

1.48e-03178814EFO_0004321
Diseaseurate measurement, bone density

FRAS1 EYS DMBT1 CASZ1 TIAM2 NOTCH4 ITPR1

1.57e-03619817EFO_0003923, EFO_0004531
DiseaseGranulomatous Slack Skin

TNFAIP3 FAS

1.66e-0322812C0376407
Diseasesystemic scleroderma

DGKQ TNFAIP3 NOTCH4

1.67e-0385813EFO_0000717
DiseaseLymphoma, T-Cell, Cutaneous

TNFAIP3 FAS

1.81e-0323812C0079773
Diseaselevel of Sphingomyelin (d40:2) in blood serum

SYNE2 PCSK9

1.81e-0323812OBA_2045181
DiseaseHypermetropia, Myopia

MCF2L2 LAMA2 CTBP2 PDE11A

1.85e-03189814HP_0000540, HP_0000545
Diseasesystemic scleroderma (is_implicated_in)

FBN1 NOTCH4

1.98e-0324812DOID:418 (is_implicated_in)
Diseasevital capacity

PCSK5 MICAL1 THBS1 XKR9 LRP2 LAMA2 CASZ1 TIAM2 ITPR1 PDE11A

2.02e-0312368110EFO_0004312
Diseaseankylosing spondylitis

PCSK5 FAS EDIL3

2.03e-0391813EFO_0003898
Diseasebrain cancer (implicated_via_orthology)

LLGL1 NOTCH2

2.32e-0326812DOID:1319 (implicated_via_orthology)
Diseasecerebrospinal fluid biomarker measurement

WFIKKN2 EDIL3 CNTN2

2.37e-0396813EFO_0006794
Diseaseblood cobalt measurement

EYS NTNG1 PLPPR1

2.74e-03101813EFO_0007577

Protein segments in the cluster

PeptideGeneStartEntry
HGNAQNDAHEFLAHC

USP26

376

Q9BXU7
LQNEAQCGHSADRHN

AGBL5

371

Q8NDL9
DNFGNCGTAHCLFQH

ADAM5

246

Q6NVV9
DASNHCDRHGVCNNF

ADAM5

356

Q6NVV9
SDCVSLHCNLNEHNH

CTBP2

236

P56545
VNSHFHCIREGCQFS

CASZ1

1296

Q86V15
QCNENPVDGHGLQCH

ADAM7

636

Q9H2U9
CQFGLAQECLHHAQD

COPB2

681

P35606
SDCRQCHQDGHQDHD

DGKQ

166

P52824
NECGLANLNGIHHFS

ANGPTL5

336

Q86XS5
CRHSGTVNFDCLHQN

CD163L1

341

Q9NR16
ECQCRSGFVLHDNKH

BMP1

726

P13497
NHRDNAGYCALHEAC

BCOR

1491

Q6W2J9
DQGLILYHQHQHSCC

POLM

356

Q9NP87
NHGGFHIQCQSEDCT

PTPN3

766

P26045
HHNGCAHLEEALSFQ

LLGL1

106

Q15334
QHNQSLECHAFLCTK

LDLRAP1

136

Q5SW96
CHLAELHAEQGCFAA

ANAPC5

471

Q9UJX4
DHFKDNHCDQGCNSE

NOTCH2

1511

Q04721
HLCQHCAADLHNTGS

FRAS1

811

Q86XX4
ASSNHGCQHECVNTD

MATN2

366

O00339
HCAQQDHGCEQLCLN

MATN2

446

O00339
HHLCRNNGTCISDNE

EYS

2341

Q5T1H1
CHENQNCIATHESNG

ITPR1

2056

Q14643
NLLECQHNGVGTHNC

HHIPL1

751

Q96JK4
LDHNHICSVQGDAFQ

LRRTM1

96

Q86UE6
LNGHNCSQVAAAKDH

IBTK

226

Q9P2D0
HEKQEGFLCAQHCLN

ATXN3L

6

Q9H3M9
LNQCLQLQHFEHDFC

MCF2L2

316

Q86YR7
FEFENQCHPCHHTCQ

PCSK5

926

Q92824
NQCVGHREASIHASC

PCSK9

586

Q8NBP7
CHGNALSHAFCLHQD

OR51L1

171

Q8NGJ5
CLCHDLDHRGTNNAF

PDE11A

701

Q9HCR9
HAHFESFLQAQLCQD

MICAL1

11

Q8TDZ2
CQNCQHHTAGDFCER

LAMA2

1436

P24043
CHDNSDEQLCGTLNN

LRP2

1051

P98164
HFCGANVINHFACEI

OR13H1

166

Q8NG92
LCHLDNTAHGNMACV

EIPR1

126

Q53HC9
NSGCSNCHNTILHQL

MED14

841

O60244
SNHCDNQCPHIFSKA

OCR1

6

Q9BZK8
QHSGDQQDCLQHGAD

DYRK4

461

Q9NR20
FNGIHCQHNINECEV

EDIL3

111

O43854
HNDSHTFFCCLQGGA

GLYCTK

486

Q8IVS8
GGLFCNQDLNYCTHH

DLL1

281

O00548
SFNCRCNHGFILSHN

FBN1

1911

P35555
CNHGFILSHNNDCID

FBN1

1916

P35555
NLGDNLTLQCHASHD

CNTN2

521

Q02246
GFTQHHTACIDNNEC

FBN2

2561

P35556
DECDGNHRCQHGCQN

FBN2

2616

P35556
AHQCSEAQTCVNFHG

EFEMP2

291

O95967
FSHNCNHREDAGVIC

DMBT1

1971

Q9UGM3
CQCHSGFFLSDNQHT

SCUBE1

141

Q8IWY4
QGLDDCHADALCQNT

SCUBE2

51

Q9NQ36
CHCREGFFLSDNQHT

SCUBE3

136

Q8IX30
NCLNDCFHILQLQHA

OSBPL11

266

Q9BXB4
LLHCQNGGTCHNNVR

NTNG1

471

Q9Y2I2
NQCIHQLCQGEGHVA

RTL3

326

Q8N8U3
YHTCEASNFQCRNGH

SORL1

1196

Q92673
TCVQDFSNCSGHLGH

POLR1A

66

O95602
ALVLHGHNQNCDCSP

TRPC4AP

436

Q8TEL6
ACFSEEGCLYQLNHH

SYNE2

981

Q8WXH0
SADCQAHHQFINNGN

PLPPR1

166

Q8TBJ4
PCLNHADCHDLLNGF

NOTCH4

521

Q99466
NRCQNCFHPEEAHGA

TRIOBP

21

Q9H2D6
GNYDACLQHLACLQD

CNOT10

41

Q9H9A5
PDACFNHNGEHRCEN

THBS1

596

P07996
HGDCQDLQKQHSDPC

VWF

556

P04275
NHITSRDCNGHLLNC

TIAM2

126

Q8IVF5
HDEHCAACKRGANLQ

PHF21B

351

Q96EK2
TLNVQHNGFCERCHN

TNFAIP3

486

P21580
TQNLEGLHHDGQFCH

FAS

46

P25445
CCEHLLDHITNNQDF

PPM1A

71

P35813
ENHHECNQCGKAFST

ZNF558

261

Q96NG5
QVFSCHHCGKNLSQD

ZNF398

341

Q8TD17
VIHSDARPFNCQHCN

ZBTB41

716

Q5SVQ8
HACPQLSCLHQNQDE

nan

181

Q6ZSR6
SHNHIDAQTFACPDC

ZNF646

1576

O15015
ESLNHHYHLNCGCQI

TIMP4

146

Q99727
HFTSTHCVNGNFQCE

ZNF518A

196

Q6AHZ1
CSICDQGNFRKHDHV

ZBTB1

636

Q9Y2K1
LFGKCLEHNFDCHNN

ZNF569

141

Q5MCW4
CGRAFSQCSSLIQHH

ZNF879

321

B4DU55
CNECGNSFRNHSHLT

ZNF502

241

Q8TBZ5
DNFQDKTCHLTNHCI

TTL

231

Q8NG68
FCHEDRQLLQGHCHA

TTC34

126

A8MYJ7
CEECGQAFSQNSHLL

ZNF619

246

Q8N2I2
LCGKQFCFSANLHQH

ZNF772

176

Q68DY9
GQESQHCFLLLHCLQ

XKR9

71

Q5GH70
NNCLTFTFGHCHRNL

WFIKKN2

351

Q8TEU8