Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	tubulin binding	TPR MID2 CEP295NL TOGARAM1 STMND1 TUBGCP4 CCDC61 GLI1 MID1 KLC3	7.36e-05	428	103	10	GO:0015631
GeneOntologyMolecularFunction	coumarin 7-hydroxylase activity	CYP2A6 CYP2A13	7.88e-05	3	103	2	GO:0008389
GeneOntologyMolecularFunction	microtubule binding	MID2 CEP295NL TOGARAM1 TUBGCP4 CCDC61 GLI1 MID1 KLC3	1.96e-04	308	103	8	GO:0008017
GeneOntologyBiologicalProcess	centriole assembly	CEP295NL RTTN CCDC61 KAT2B CEP72	6.07e-06	53	101	5	GO:0098534
GeneOntologyBiologicalProcess	regulation of microtubule-based process	TPR CEP295NL LAMP1 TOGARAM1 STMND1 KAT2B MID1 PKD1 SENP6	1.39e-05	293	101	9	GO:0032886
GeneOntologyBiologicalProcess	microtubule cytoskeleton organization	TPR CEP295NL RTTN TOGARAM1 STMND1 TUBGCP4 CCDC61 CEP68 KAT2B CEP72 MID1 PKD1 SENP6	4.95e-05	720	101	13	GO:0000226
GeneOntologyBiologicalProcess	microtubule-based process	TPR CEP295NL RTTN LAMP1 TOGARAM1 STMND1 TUBGCP4 CCDC61 WDPCP CEP68 KAT2B CEP72 MID1 PKD1 SENP6 KLC3	5.38e-05	1058	101	16	GO:0007017
GeneOntologyBiologicalProcess	centriole replication	CEP295NL RTTN KAT2B CEP72	8.22e-05	47	101	4	GO:0007099
GeneOntologyCellularComponent	microtubule organizing center	CEP295NL RTTN TRIOBP MARCHF7 TOGARAM1 TUBGCP4 CCDC61 CEP68 FRY KAT2B PLEKHG6 CEP72 KIAA1217 MID1 TOP2A CPEB1	8.19e-06	919	101	16	GO:0005815
GeneOntologyCellularComponent	centrosome	CEP295NL RTTN TRIOBP MARCHF7 TUBGCP4 CCDC61 CEP68 FRY KAT2B PLEKHG6 CEP72 KIAA1217 MID1 CPEB1	1.98e-05	770	101	14	GO:0005813
Domain	TF_fork_head_CS_2	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3	1.10e-04	46	101	4	IPR030456
Domain	TF_fork_head_CS_1	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3	1.20e-04	47	101	4	IPR018122
Domain	FH	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3	1.42e-04	49	101	4	SM00339
Domain	FORK_HEAD_1	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3	1.42e-04	49	101	4	PS00657
Domain	FORK_HEAD_2	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3	1.42e-04	49	101	4	PS00658
Domain	Fork_head_dom	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3	1.42e-04	49	101	4	IPR001766
Domain	FORK_HEAD_3	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3	1.42e-04	49	101	4	PS50039
Domain	Forkhead	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3	1.42e-04	49	101	4	PF00250
Domain	CTNNB1-bd_N	TCF7L2 TCF7L1	1.73e-04	4	101	2	IPR013558
Domain	Cyt_P450_E_grp-I_CYP2A-like	CYP2A6 CYP2A13	1.73e-04	4	101	2	IPR008067
Domain	CTNNB1_binding	TCF7L2 TCF7L1	1.73e-04	4	101	2	PF08347
Domain	TCF/LEF	TCF7L2 TCF7L1	1.73e-04	4	101	2	IPR024940
Domain	COS_domain	MID2 MID1	1.84e-03	12	101	2	IPR017903
Domain	COS	MID2 MID1	1.84e-03	12	101	2	PS51262
Domain	LDLRA_2	LDLRAD2 LRP10 PKD1	2.36e-03	49	101	3	PS50068
Domain	-	LDLRAD2 NRP2 LRP10	2.80e-03	52	101	3	2.60.120.290
Domain	Bbox_C	MID2 MID1	2.90e-03	15	101	2	IPR003649
Domain	BBC	MID2 MID1	2.90e-03	15	101	2	SM00502
Domain	CUB_dom	LDLRAD2 NRP2 LRP10	3.63e-03	57	101	3	IPR000859
Domain	PH	ARHGEF19 TRIOBP PHLDA2 PLEKHG6 DGKK TECPR1	4.01e-03	278	101	6	SM00233
Domain	PH_DOMAIN	ARHGEF19 TRIOBP PHLDA2 PLEKHG6 DGKK TECPR1	4.08e-03	279	101	6	PS50003
Domain	PH_domain	ARHGEF19 TRIOBP PHLDA2 PLEKHG6 DGKK TECPR1	4.16e-03	280	101	6	IPR001849
Domain	-	SACS TOP2A	5.16e-03	20	101	2	3.30.565.10
Domain	-	ARHGEF19 TRIOBP PHLDA2 PLEKHG6 DGKK HOMER3 TECPR1	5.33e-03	391	101	7	2.30.29.30
Domain	HATPase_C	SACS TOP2A	5.69e-03	21	101	2	IPR003594
Pathway	KEGG_MEDICUS_ENV_FACTOR_NNK_TO_DNA_ADDUCTS	CYP2A6 CYP2A13	1.89e-04	5	62	2	M47808
Pathway	KEGG_THYROID_CANCER	TPR TCF7L2 TCF7L1	2.73e-04	29	62	3	M523
Pathway	REACTOME_RUNX3_REGULATES_WNT_SIGNALING	TCF7L2 TCF7L1	2.82e-04	6	62	2	MM15542
Pathway	KEGG_MEDICUS_PATHOGEN_SALMONELLA_AVRA_TO_BETA_CATENIN_SIGNALING_PATHWAY	TCF7L2 TCF7L1	2.82e-04	6	62	2	M47736
Pathway	KEGG_MEDICUS_PATHOGEN_KSHV_LANA_TO_WNT_SIGNALING_PATHWAY	TCF7L2 TCF7L1	3.94e-04	7	62	2	M47465
Pathway	REACTOME_REGULATION_OF_MITF_M_DEPENDENT_GENES_INVOLVED_IN_CELL_CYCLE_AND_PROLIFERATION	TCF7L2 TCF7L1	5.24e-04	8	62	2	MM17229
Pathway	REACTOME_BINDING_OF_TCF_LEF_CTNNB1_TO_TARGET_GENE_PROMOTERS	TCF7L2 TCF7L1	5.24e-04	8	62	2	M27359
Pathway	KEGG_MEDICUS_VARIANT_CDH1_REDUCED_EXPRESSION_TO_BETA_CATENIN_SIGNALING_PATHWAY	TCF7L2 TCF7L1	5.24e-04	8	62	2	M47413
Pathway	REACTOME_RUNX3_REGULATES_WNT_SIGNALING	TCF7L2 TCF7L1	5.24e-04	8	62	2	M27821
Pubmed	Neural transcription factors bias cleavage stage blastomeres to give rise to neural ectoderm.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3	1.26e-09	6	107	4	27092474
Pubmed	The mouse fkh-2 gene. Implications for notochord, foregut, and midbrain regionalization.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3	5.87e-09	8	107	4	8530406
Pubmed	An amphioxus winged helix/forkhead gene, AmphiFoxD: insights into vertebrate neural crest evolution.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3	1.05e-08	9	107	4	12412011
Pubmed	A genetic study of the suppressors of the Engrailed-1 cerebellar phenotype.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3	5.93e-08	13	107	4	16884697
Pubmed	Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3	5.93e-08	13	107	4	7957066
Pubmed	Six members of the mouse forkhead gene family are developmentally regulated.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3	1.13e-07	15	107	4	7689224
Pubmed	Strain-specific modifier genes of Cecr2-associated exencephaly in mice: genetic analysis and identification of differentially expressed candidate genes.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3	1.13e-07	15	107	4	22045912
Pubmed	Expression of the winged helix genes fkh-4 and fkh-5 defines domains in the central nervous system.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3	1.50e-07	16	107	4	8861101
Pubmed	Developmental competence of the gut endoderm: genetic potentiation by GATA and HNF3/fork head proteins.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3	1.50e-07	16	107	4	10208738
Pubmed	FOXD4a and FOXD4b, two new winged helix transcription factors, are expressed in human leukemia cell lines.	FOXD4L6 FOXD4L5 FOXD4L4	2.82e-07	5	107	3	12234674
Pubmed	Functional equivalency between Otx2 and Otx1 in development of the rostral head.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3	3.17e-07	19	107	4	9895322
Pubmed	Forkhead transcription factor Foxf2 (LUN)-deficient mice exhibit abnormal development of secondary palate.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3	3.95e-07	20	107	4	12812790
Pubmed	Sequential roles for Otx2 in visceral endoderm and neuroectoderm for forebrain and midbrain induction and specification.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3	4.87e-07	21	107	4	9449667
Pubmed	Crucial roles of Foxa2 in mouse anterior-posterior axis polarization via regulation of anterior visceral endoderm-specific genes.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3	5.93e-07	22	107	4	17389379
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	TPR BCLAF1 ZNF507 TATDN2 MCM4 PACS1 CTR9 RBMX2 CBFA2T2 MDC1 SENP6 RIMS1 TOP2A	7.88e-07	774	107	13	15302935
Pubmed	Otx2 is required to respond to signals from anterior neural ridge for forebrain specification.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3	8.58e-07	24	107	4	11820816
Pubmed	A Requirement for Zic2 in the Regulation of Nodal Expression Underlies the Establishment of Left-Sided Identity.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3	8.58e-07	24	107	4	29992973
Pubmed	Ssdp1 regulates head morphogenesis of mouse embryos by activating the Lim1-Ldb1 complex.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3	1.20e-06	26	107	4	15857913
Pubmed	Molecular profiling of synovial joints: use of microarray analysis to identify factors that direct the development of the knee and elbow.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3	1.90e-06	29	107	4	22972626
Pubmed	Genome-scale study of transcription factor expression in the branching mouse lung.	FOXD4L6 FOXD4L5 KAT2B FOXD4L4 FOXD4L3	2.08e-06	67	107	5	22711520
Pubmed	Hippocampus development and generation of dentate gyrus granule cells is regulated by LEF1.	TCF7L2 NRP2 TCF7L1	6.10e-06	12	107	3	10631168
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	CYP2A6 CYP2A13 CCDC185 NOC2L BCLAF1 PCLO HP1BP3 SCML4 NRXN3 SACS CTR9 RBMX2 DGKK SCN9A RIMS1 TOP2A	8.67e-06	1442	107	16	35575683
Pubmed	Histone acetyltransferase PCAF is required for Hedgehog-Gli-dependent transcription and cancer cell proliferation.	KAT2B GLI1	9.38e-06	2	107	2	23943798
Pubmed	PCAF inhibits hepatocellular carcinoma metastasis by inhibition of epithelial-mesenchymal transition by targeting Gli-1.	KAT2B GLI1	9.38e-06	2	107	2	26945969
Pubmed	Evaluation of inhibition selectivity for human cytochrome P450 2A enzymes.	CYP2A6 CYP2A13	9.38e-06	2	107	2	22696418
Pubmed	Suppressed hepatocyte proliferation via a ROS-HNE-P21 pathway is associated with nicotine- and cotinine-enhanced alcoholic fatty liver in mice.	CYP2A6 CYP2A13	9.38e-06	2	107	2	30876690
Pubmed	CYP2A5 induction and hepatocellular stress: an adaptive response to perturbations of heme homeostasis.	CYP2A6 CYP2A13	9.38e-06	2	107	2	21395539
Pubmed	Species differences in coumarin metabolism: a molecular modelling evaluation of CYP2A interactions.	CYP2A6 CYP2A13	9.38e-06	2	107	2	12162851
Pubmed	Molecular characterization of the murine Coh locus: an amino acid difference at position 117 confers high and low coumarin 7-hydroxylase activity in P450coh.	CYP2A6 CYP2A13	9.38e-06	2	107	2	1302041
Pubmed	Structural alteration of mouse P450coh by mutation of glycine-207 to proline: spin equilibrium, enzyme kinetics, and heat sensitivity.	CYP2A6 CYP2A13	9.38e-06	2	107	2	8395817
Pubmed	Mid1/Mid2 expression in craniofacial development and a literature review of X-linked opitz syndrome.	MID2 MID1	9.38e-06	2	107	2	26788540
Pubmed	Absence of cytochrome P450 2A5 enhances alcohol-induced liver injury in mice.	CYP2A6 CYP2A13	9.38e-06	2	107	2	25804444
Pubmed	Effect of pyrazole, cobalt and phenobarbital on mouse liver cytochrome P-450 2a-4/5 (Cyp2a-4/5) expression.	CYP2A6 CYP2A13	9.38e-06	2	107	2	1520280
Pubmed	Restricted high level expression of Tcf-4 protein in intestinal and mammary gland epithelium.	TCF7L2 TCF7L1	9.38e-06	2	107	2	9916915
Pubmed	Role of CYP2A13 in the bioactivation and lung tumorigenicity of the tobacco-specific lung procarcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone: in vivo studies using a CYP2A13-humanized mouse model.	CYP2A6 CYP2A13	9.38e-06	2	107	2	23917075
Pubmed	Nicotine enhances alcoholic fatty liver in mice: Role of CYP2A5.	CYP2A6 CYP2A13	9.38e-06	2	107	2	30222954
Pubmed	Up-regulation of CYP2A5 expression by porphyrinogenic agents in mouse liver.	CYP2A6 CYP2A13	9.38e-06	2	107	2	7543189
Pubmed	Genomic Landscape of Experimental Bladder Cancer in Rodents and Its Application to Human Bladder Cancer: Gene Amplification and Potential Overexpression of Cyp2a5/CYP2A6 Are Associated with the Invasive Phenotype.	CYP2A6 CYP2A13	9.38e-06	2	107	2	27902773
Pubmed	Characterization and regulation of sex-specific mouse steroid hydroxylase genes.	CYP2A6 CYP2A13	9.38e-06	2	107	2	2372744
Pubmed	Metabolic effects of CYP2A6 and CYP2A13 on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced gene mutation--a mammalian cell-based mutagenesis approach.	CYP2A6 CYP2A13	9.38e-06	2	107	2	21473878
Pubmed	The CYP2A gene subfamily: species differences, regulation, catalytic activities and role in chemical carcinogenesis.	CYP2A6 CYP2A13	9.38e-06	2	107	2	7581481
Pubmed	A gene family of HMG-box transcription factors with homology to TCF-1.	TCF7L2 TCF7L1	9.38e-06	2	107	2	1741298
Pubmed	Circadian Regulation of Hepatic Cytochrome P450 2a5 by Peroxisome Proliferator-Activated Receptor γ.	CYP2A6 CYP2A13	9.38e-06	2	107	2	30154104
Pubmed	Interstrain differences in the expression and activity of Cyp2a5 in the mouse liver.	CYP2A6 CYP2A13	9.38e-06	2	107	2	28298240
Pubmed	Genetic polymorphisms for a phenobarbital-inducible cytochrome P-450 map to the Coh locus in mice.	CYP2A6 CYP2A13	9.38e-06	2	107	2	6309775
Pubmed	Mechanism-based inhibition of cytochrome P450 (CYP)2A6 by chalepensin in recombinant systems, in human liver microsomes and in mice in vivo.	CYP2A6 CYP2A13	9.38e-06	2	107	2	21418183
Pubmed	Role of CYP2A5 in the bioactivation of the lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in mice.	CYP2A6 CYP2A13	9.38e-06	2	107	2	22262919
Pubmed	Modulation of cytochrome P450 2A5 activity by lipopolysaccharide: low-dose effects and non-monotonic dose-response relationship.	CYP2A6 CYP2A13	9.38e-06	2	107	2	25635819
Pubmed	Genetic variation between mice in their metabolism of coumarin and its derivatives.	CYP2A6 CYP2A13	9.38e-06	2	107	2	566237
Pubmed	Role of CYP2A5 in the clearance of nicotine and cotinine: insights from studies on a Cyp2a5-null mouse model.	CYP2A6 CYP2A13	9.38e-06	2	107	2	19923441
Pubmed	Effects of lipopolysaccharide-stimulated inflammation and pyrazole-mediated hepatocellular injury on mouse hepatic Cyp2a5 expression.	CYP2A6 CYP2A13	9.38e-06	2	107	2	12499123
Pubmed	Identification and characterization of a 44 kDa protein that binds specifically to the 3'-untranslated region of CYP2a5 mRNA: inducibility, subcellular distribution and possible role in mRNA stabilization.	CYP2A6 CYP2A13	9.38e-06	2	107	2	8611142
Pubmed	Function and regulation of the Cyp2a5/CYP2A6 genes in response to toxic insults in the liver.	CYP2A6 CYP2A13	9.38e-06	2	107	2	22497566
Pubmed	Coumarin toxicity in different strains of mice.	CYP2A6 CYP2A13	9.38e-06	2	107	2	665441
Pubmed	Essential role of the cytochrome P450 enzyme CYP2A5 in olfactory mucosal toxicity of naphthalene.	CYP2A6 CYP2A13	9.38e-06	2	107	2	24104196
Pubmed	The role of CYP2A5 in liver injury and fibrosis: chemical-specific difference.	CYP2A6 CYP2A13	9.38e-06	2	107	2	26363552
Pubmed	Mouse liver P450Coh: genetic regulation of the pyrazole-inducible enzyme and comparison with other P450 isoenzymes.	CYP2A6 CYP2A13	9.38e-06	2	107	2	2712571
Pubmed	hnRNPH1 recruits PTBP2 and SRSF3 to modulate alternative splicing in germ cells.	TCF7L2 TCF7L1 CPEB1	2.65e-05	19	107	3	35739118
Pubmed	Coactivator PGC-1alpha regulates the fasting inducible xenobiotic-metabolizing enzyme CYP2A5 in mouse primary hepatocytes.	CYP2A6 CYP2A13	2.81e-05	3	107	2	18602936
Pubmed	Wnt/beta-catenin signaling promotes expansion of Isl-1-positive cardiac progenitor cells through regulation of FGF signaling.	TCF7L2 TCF7L1	2.81e-05	3	107	2	17607356
Pubmed	Expression of cytochrome P450 2A5 in a glucose-6-phosphate dehydrogenase-deficient mouse model of oxidative stress.	CYP2A6 CYP2A13	2.81e-05	3	107	2	18068688
Pubmed	Regulation of bile acid metabolism in mouse models with hydrophobic bile acid composition.	CYP2A6 CYP2A13	2.81e-05	3	107	2	31645370
Pubmed	Rip locus: regulation of female-specific isozyme (I-P-450(16 alpha) of testosterone 16 alpha-hydroxylase in mouse liver, chromosome localization, and cloning of P-450 cDNA.	CYP2A6 CYP2A13	2.81e-05	3	107	2	3219345
Pubmed	Reciprocal regulation of sex-dependent expression of testosterone 15 alpha-hydroxylase (P-450(15 alpha)) in liver and kidney of male mice by androgen. Evidence for a single gene.	CYP2A6 CYP2A13	2.81e-05	3	107	2	3346244
Pubmed	Zfp30, a KRAB domain containing zinc finger protein gene, maps to mouse chromosome 7.	CYP2A6 CYP2A13	2.81e-05	3	107	2	7849402
Pubmed	Topoisomerase IIα mediates TCF-dependent epithelial-mesenchymal transition in colon cancer.	TCF7L2 TOP2A	2.81e-05	3	107	2	26947016
Pubmed	A dynamic exchange of TCF3 and TCF4 transcription factors controls MYC expression in colorectal cancer cells.	TCF7L2 TCF7L1	2.81e-05	3	107	2	25659031
Pubmed	Mechanisms of olfactory toxicity of the herbicide 2,6-dichlorobenzonitrile: essential roles of CYP2A5 and target-tissue metabolic activation.	CYP2A6 CYP2A13	2.81e-05	3	107	2	20840855
Pubmed	Alteration of mouse cytochrome P450coh substrate specificity by mutation of a single amino-acid residue.	CYP2A6 CYP2A13	2.81e-05	3	107	2	2733794
Pubmed	In vivo transcriptional governance of hair follicle stem cells by canonical Wnt regulators.	TCF7L2 TCF7L1	2.81e-05	3	107	2	24463605
Pubmed	Ethanol induction of CYP2A5: role of CYP2E1-ROS-Nrf2 pathway.	CYP2A6 CYP2A13	2.81e-05	3	107	2	22552773
Pubmed	A trans-acting locus regulates transcriptional repression of the female-specific steroid 15 alpha-hydroxylase gene in male mice.	CYP2A6 CYP2A13	2.81e-05	3	107	2	8297477
Pubmed	Lack of the steroid 15 alpha-hydroxylase gene (Cyp2a-4) in wild mouse strain Mus spretus: rapid evolution of the P450 gene superfamily.	CYP2A6 CYP2A13	2.81e-05	3	107	2	8188299
Pubmed	MID1 and MID2 homo- and heterodimerise to tether the rapamycin-sensitive PP2A regulatory subunit, alpha 4, to microtubules: implications for the clinical variability of X-linked Opitz GBBB syndrome and other developmental disorders.	MID2 MID1	2.81e-05	3	107	2	11806752
Pubmed	Site-directed mutagenesis of mouse steroid 7 alpha-hydroxylase (cytochrome P-450(7) alpha): role of residue-209 in determining steroid-cytochrome P-450 interaction.	CYP2A6 CYP2A13	2.81e-05	3	107	2	8484736
Pubmed	TCF-3, 4 protein expression correlates with beta-catenin expression in MSS and MSI-H colorectal cancer from HNPCC patients but not in sporadic colorectal cancers.	TCF7L2 TCF7L1	2.81e-05	3	107	2	20532534
Pubmed	Limited heme synthesis in porphobilinogen deaminase-deficient mice impairs transcriptional activation of specific cytochrome P450 genes by phenobarbital.	CYP2A6 CYP2A13	2.81e-05	3	107	2	11106424
Pubmed	Comparison of hamster and mouse reveals interspecies differences in the regulation of hepatic CYP2A isozymes.	CYP2A6 CYP2A13	2.81e-05	3	107	2	8250953
Pubmed	Regulation of CYP2A5 gene by the transcription factor nuclear factor (erythroid-derived 2)-like 2.	CYP2A6 CYP2A13	2.81e-05	3	107	2	17303623
Pubmed	The structure and characterization of type I P-450(15) alpha gene as major steroid 15 alpha-hydroxylase and its comparison with type II P-450(15) alpha gene.	CYP2A6 CYP2A13	2.81e-05	3	107	2	2703500
Pubmed	PCAF ubiquitin ligase activity inhibits Hedgehog/Gli1 signaling in p53-dependent response to genotoxic stress.	KAT2B GLI1	2.81e-05	3	107	2	24013724
Pubmed	Cerium-induced strain-dependent increase in Cyp2a-4/5 (cytochrome P4502a-4/5) expression in the liver and kidneys of inbred mice.	CYP2A6 CYP2A13	2.81e-05	3	107	2	1417950
Pubmed	Polycystin-1 interacts with inositol 1,4,5-trisphosphate receptor to modulate intracellular Ca2+ signaling with implications for polycystic kidney disease.	ITPR1 PKD1	2.81e-05	3	107	2	19854836
Pubmed	Impact of nicotine metabolism on nicotine's pharmacological effects and behavioral responses: insights from a Cyp2a(4/5)bgs-null mouse.	CYP2A6 CYP2A13	2.81e-05	3	107	2	24045421
Pubmed	SYMPTOM SEVERITY IN SCHIZOPHRENIA PATIENTS WITH NPAS3, DYSBINDIN-1 AND/OR TRIOBP PROTEIN PATHOLOGY IN THEIR BLOOD SERUM: A PANSS-BASED FOLLOW UP STUDY.	NPAS3 TRIOBP	2.81e-05	3	107	2	37480305
Pubmed	Highly homologous mouse Cyp2a4 and Cyp2a5 genes are differentially expressed in the liver and both express long non-coding antisense RNAs.	CYP2A6 CYP2A13	2.81e-05	3	107	2	32987105
Pubmed	TCF/LEF regulation of the topologically associated domain ADI promotes mESCs to exit the pluripotent ground state.	TCF7L2 TCF7L1	2.81e-05	3	107	2	34525377
Pubmed	NFBD1/MDC1 is phosphorylated by PLK1 and controls G2/M transition through the regulation of a TOPOIIα-mediated decatenation checkpoint.	MDC1 TOP2A	2.81e-05	3	107	2	24349352
Pubmed	Close linkage of the cytochrome P450IIA gene subfamily (Cyp2a) to Cyp2b and Coh on mouse chromosome 7.	CYP2A6 CYP2A13	2.81e-05	3	107	2	1973143
Pubmed	Alteration of the substrate specificity of mouse 2A P450s by the identity of residue-209: steroid-binding site and orientation.	CYP2A6 CYP2A13	2.81e-05	3	107	2	22217847
Pubmed	Mouse steroid 15 alpha-hydroxylase gene family: identification of type II P-450(15)alpha as coumarin 7-hydroxylase.	CYP2A6 CYP2A13	2.81e-05	3	107	2	2765478
Pubmed	A novel defensive mechanism against acetaminophen toxicity in the mouse lateral nasal gland: role of CYP2A5-mediated regulation of testosterone homeostasis and salivary androgen-binding protein expression.	CYP2A6 CYP2A13	2.81e-05	3	107	2	21252290
Pubmed	Mitochondrial targeting of bilirubin regulatory enzymes: An adaptive response to oxidative stress.	CYP2A6 CYP2A13	2.81e-05	3	107	2	25478736
Pubmed	Sexual dimorphism of testosterone 15 alpha-hydroxylase mRNA levels in mouse liver. cDNA cloning and regulation.	CYP2A6 CYP2A13	2.81e-05	3	107	2	2415518
Pubmed	Diverse LEF/TCF Expression in Human Colorectal Cancer Correlates with Altered Wnt-Regulated Transcriptome in a Meta-Analysis of Patient Biopsies.	TCF7L2 TCF7L1	2.81e-05	3	107	2	32403323
Pubmed	Aryl hydrocarbon receptor nuclear translocator and upstream stimulatory factor regulate Cytochrome P450 2a5 transcription through a common E-box site.	CYP2A6 CYP2A13	2.81e-05	3	107	2	17466327
Pubmed	Differential distribution of CYP2A6 and CYP2A13 in the human respiratory tract.	CYP2A6 CYP2A13	2.81e-05	3	107	2	22890016
Pubmed	High-fat diet induces fibrosis in mice lacking CYP2A5 and PPARα: a new model for steatohepatitis-associated fibrosis.	CYP2A6 CYP2A13	2.81e-05	3	107	2	32877213
Pubmed	Experimental nonalcoholic fatty liver disease in mice leads to cytochrome p450 2a5 upregulation through nuclear factor erythroid 2-like 2 translocation.	CYP2A6 CYP2A13	2.81e-05	3	107	2	24191237
Pubmed	Generation and characterization of a novel Cyp2a(4/5)bgs-null mouse model.	CYP2A6 CYP2A13	2.81e-05	3	107	2	23073733
Cytoband	9q21.11	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3	7.29e-07	30	107	4	9q21.11
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	VN1R4 CYP2A6 SRRM5 CYP2A13 GGN ZNF507 CCDC61 SSC5D SPINT2 KLC3	4.85e-04	1192	107	10	chr19q13
GeneFamily	Zinc fingers RANBP2-type \|RNA binding motif containing	TAB3 ZRANB1	1.97e-03	21	57	2	89
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	FKBP15 NOC2L ITPR1 SACS	2.54e-03	181	57	4	694
GeneFamily	GCN5 related N-acetyltransferases	NAT16 KAT2B	2.58e-03	24	57	2	1134
Coexpression	MANNO_MIDBRAIN_NEUROTYPES_HGABA	TANC2 FKBP15 PCLO NPAS3 TATDN2 ANO8 FOXD4L5 NRP2 PACS1 FRY NRXN3 SPINT2 SCN9A AUTS2 RIMS1 CAMTA1	8.30e-06	1106	105	16	M39071
Coexpression	GSE40274_FOXP3_VS_FOXP3_AND_LEF1_TRANSDUCED_ACTIVATED_CD4_TCELL_DN	TCF7L2 NOC2L BCLAF1 COG3 NRP2 ECHDC3 CEP72	1.64e-05	200	105	7	M9188
Coexpression	MIKKELSEN_NPC_HCP_WITH_H3K4ME3_AND_H3K27ME3	FOXD4L6 FOXD4L5 RASSF5 GJA3 FOXD4L4 FOXD4L3 CPEB1	2.77e-05	217	105	7	MM861
ToppCell	Substantia_nigra-Macroglia-POLYDENDROCYTE-P3-Tnr-Polydendrocyte.Tnr.Cspg5_(Cspg5)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	RTTN CEP72 GLI1 MID1 KLC3	2.59e-06	90	107	5	3817a5b0235e632d976ea565175bdbebbd959bf0
ToppCell	Substantia_nigra-Macroglia-POLYDENDROCYTE-P3-Tnr-Polydendrocyte.Tnr.Cspg5_(Cspg5)-\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	RTTN CEP72 GLI1 MID1 KLC3	2.59e-06	90	107	5	a528f5dcee1a356dea89ff2588d2e0f276f2d5fc
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NPAS3 PCARE GJA3 FRY TCF7L1 CPEB1	3.51e-06	170	107	6	60bbd738c12e64e483485586c30057304884f5a6
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.5\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TANC2 CCDC185 GRHL1 KIAA1217 NKTR RIMS1	4.72e-06	179	107	6	6e965e424eebef50f0202cff75f458be395cfca1
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L5-6_SST_KLHL14\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NPAS3 CRACD KIAA1217 DGKK MID1 SCN9A	5.36e-06	183	107	6	439b1d1373b7cc73d65f3b59037a6def7cf8f4ba
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2-D175\|Adult / Lineage, Cell type, age group and donor	TANC2 PCLO NRXN3 SCN9A AUTS2 TCF7L1	6.26e-06	188	107	6	ec38def1fdbb34ed9b30244806975bd5a4370164
ToppCell	mild-low-quality_cells\|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	TANC2 RTTN ZNF507 ATG2A SCML4 NKTR	8.17e-06	197	107	6	e4331969bd911d1ebb5453f40a7057297b5389b4
ToppCell	Somatosensory_Cortex_(S1)-Neuronal\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PCLO ITPR1 FRY NRXN3 PKD1 RIMS1	8.41e-06	198	107	6	c01091ef18e096d792ea2a7a715764a5b215355f
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)-B3GAT2\|Neuronal / cells hierarchy compared to all cells using T-Statistic	NPAS3 CRACD NRXN3 KIAA1217 MID1 AUTS2	8.91e-06	200	107	6	858421b91f5207b7934b5c219752cb9322a3da31
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)-B3GAT2-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	NPAS3 CRACD NRXN3 KIAA1217 MID1 AUTS2	8.91e-06	200	107	6	a7022762c1d8aedb7b3e9605873b1e68b9907b35
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-1m-Mesenchymal-Mesoderm\|1m / Sample Type, Dataset, Time_group, and Cell type.	MID2 TOGARAM1 ATG2A PHLDA2 RASSF5 CPEB1	8.91e-06	200	107	6	c0ad32e9dd7f481c2665587fd8bd9fffc2e725f9
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)-B3GAT2--L4-6\|Neuronal / cells hierarchy compared to all cells using T-Statistic	NPAS3 CRACD NRXN3 KIAA1217 MID1 AUTS2	8.91e-06	200	107	6	2131c8e7fa054b79906eaf60536da892438b09cd
ToppCell	Frontal_cortex-Neuronal-Inhibitory\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	NPAS3 CRACD NRXN3 TMEM132E SCN9A	5.50e-05	169	107	5	78eb70dd916724e476eabccf18fb7fcec4210308
ToppCell	368C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)-\|368C / Donor, Lineage, Cell class and subclass (all cells)	PCLO MCM4 STMND1 CEP72 TOP2A	6.49e-05	175	107	5	fd8b5b756f3df4a04938785f3d9edbb6f1cd20f6
ToppCell	368C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)\|368C / Donor, Lineage, Cell class and subclass (all cells)	PCLO MCM4 STMND1 CEP72 TOP2A	6.49e-05	175	107	5	36c140540497bbe1c5f08fac2d94f08cac18fabb
ToppCell	facs-Lung-18m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l49\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ARHGEF19 SMIM41 GLI1 AUTS2 CPEB1	7.03e-05	178	107	5	cb9a446c145b1435cfe12a1d4568aed0924a6a20
ToppCell	wk_20-22-Epithelial-Proximal_epithelial-basal_late\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	CYP2A13 NPAS3 PHLDA2 PLEKHG6 CEP72	7.03e-05	178	107	5	03f22485074b3cbf9a6ad4d543c5bbfa826dc741
ToppCell	wk_20-22-Hematologic-Myeloid-aDC_1\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	FOXD4L6 PHLDA2 FOXD4L4 FOXD4L3 IL6R	7.03e-05	178	107	5	fd2bdb4796e86c8cff2d25f0c730ffea21db8787
ToppCell	MatrixFB-Fibroblast-A\|MatrixFB / shred on cell class and cell subclass (v4)	TMEM119 SMIM41 NRP2 TRIL IL6R	7.41e-05	180	107	5	adc64ad6033af705dd7b9163a83e20ef5c59f6eb
ToppCell	343B-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	TUBGCP4 C17orf58 TAB3 SPINT2 IL6R	7.81e-05	182	107	5	c98da2db197b1531204e116600ff51891e5c17af
ToppCell	Children_(3_yrs)-Epithelial-lung_goblet_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CYP2A13 GRHL1 NRXN3 KIAA1217 RIMS1	7.81e-05	182	107	5	3f1a666fe27dd7529c114539ed5f6b8ca585c875
ToppCell	facs-Marrow-T_cells-18m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HOXA11 SSC5D GRHL1 TMEM132E KLC3	8.01e-05	183	107	5	bc24145855bf4d027a8058bf92bc796c10f241bb
ToppCell	facs-Marrow-T_cells-18m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HOXA11 SSC5D GRHL1 TMEM132E KLC3	8.01e-05	183	107	5	4c325ee6da070513097a11445ec95b0415ffd8a2
ToppCell	Control-Epithelial-Club\|Epithelial / Disease state, Lineage and Cell class	CYP2A6 CYP2A13 GRHL1 KIAA1217 RIMS1	8.43e-05	185	107	5	6814b3c94c7558443c038a227b5c8563d2cfeac4
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NPAS3 PCARE GJA3 FRY TCF7L1	8.65e-05	186	107	5	1094c7140131454b2583200e1c01e81ccab3db23
ToppCell	Substantia_nigra-Neuronal-Inhibitory\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	RASSF5 NRXN3 SCN9A RIMS1 CAMTA1	8.65e-05	186	107	5	9d3efe2a4feea2bc205a7e45b9b9f9ed9b3609ce
ToppCell	pdx-Tumor_cells-T5\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	RTTN NRP2 ITPR1 CRACD NRXN3	8.87e-05	187	107	5	7e376831a11ee72ed87abcdac631ca46ae29c250
ToppCell	droplet-Lung-immune-endo-depleted\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMEM119 SMIM41 C17orf58 NRP2 TRIL	9.32e-05	189	107	5	c3fb363bb0156ffb3367c200f548faebda64ab4a
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L4-6_SST_MTHFD2P6\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NPAS3 CRACD KIAA1217 MID1 AUTS2	9.32e-05	189	107	5	06c44746fa4f02e6e2b3b635cdf2d8dfef3754d3
ToppCell	droplet-Lung-immune-endo-depleted-3m\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMEM119 SMIM41 C17orf58 NRP2 TRIL	9.32e-05	189	107	5	2a2953f6b1b7d070d739dcaf7285fce6e097d9e4
ToppCell	PND07-28-samps-Mesenchymal-Matrix_fibroblast\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	TMEM119 SMIM41 C17orf58 NRP2 TRIL	9.32e-05	189	107	5	dc5164591dea45b420798b94dda211be03daa70c
ToppCell	PND07-28-samps-Mesenchymal-Matrix_fibroblast-FB-3\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	TMEM119 SMIM41 C17orf58 NRP2 TRIL	9.56e-05	190	107	5	1196b8ea2c44c7c80f5ee589dd517e6a413f2077
ToppCell	droplet-Lung-immune-endo-depleted-3m-Mesenchymal\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMEM119 SMIM41 C17orf58 NRP2 TRIL	9.56e-05	190	107	5	9cd147a174017ebda23cc47b6d4552d898acd092
ToppCell	368C-Endothelial_cells-Endothelial-F_(Lymphatics)\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	PCLO NRP2 SCN9A TCF7L1 HOMER3	1.00e-04	192	107	5	b016e229300c183e14c0e2bba494bf49c7899112
ToppCell	368C-Endothelial_cells-Endothelial-F_(Lymphatics)-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	PCLO NRP2 SCN9A TCF7L1 HOMER3	1.00e-04	192	107	5	ac96831492c62ad9e1f7d0b764fbdf7d8a189ad9
ToppCell	facs-Lung-EPCAM-18m\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMEM119 C17orf58 RASSF5 SPINT2 IL6R	1.03e-04	193	107	5	b9ac74357435f2f24aaede62b2a1d31b5d96a12c
ToppCell	Epithelial-club_cell\|World / Lineage, Cell type, age group and donor	CYP2A6 GRHL1 NRXN3 KIAA1217 RIMS1	1.03e-04	193	107	5	2bdd09004fa433550958ec42ba4b06271a4aaf7c
ToppCell	Neuron-Postmitotic-Inhibitory_Neuron-MGE2\|World / Primary Cells by Cluster	PCLO NPAS3 NRP2 NRXN3 SCN9A	1.05e-04	194	107	5	b42fd64b0fb95434a9e4e6586f31d26114a4074b
ToppCell	Neuron-Postmitotic-Inhibitory_Neuron-MGE2-10\|World / Primary Cells by Cluster	PCLO NPAS3 NRP2 NRXN3 SCN9A	1.05e-04	194	107	5	81e7bc6516ab8d02ccd1c76a56a3533b788c27c8
ToppCell	PND01-03-samps-Mesenchymal\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	TCF7L2 TMEM119 SMIM41 C17orf58 TRIL	1.05e-04	194	107	5	4f9bd0ded0dde1df885850714f29e73e992539a5
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CYP2A13 PHLDA2 NRP2 SPINT2 RIMS1	1.08e-04	195	107	5	6095bb237d7bc75cbaeaeb492f6948f3c3fa4848
ToppCell	E17.5-Mesenchymal-mesenchymal_fibroblast-alveolar_fibroblast_Wnt2-pa\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	TMEM119 SMIM41 C17orf58 TRIL IL6R	1.08e-04	195	107	5	b072fdc2131173f562e55dd78226eaf2c57d3690
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PCLO FRY NRXN3 PKD1 RIMS1	1.11e-04	196	107	5	676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCell	wk_08-11-Epithelial-Airway_epithelial_progenitor-epi-airway_progenitor_early\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	ARHGEF19 PCLO GRHL1 NRXN3 SPINT2	1.13e-04	197	107	5	4ae08ccb6f1da626c4f0fb0140a2811cb6e31ba1
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-2M-Neuronal-ventral_progenitors_and_neurons_1\|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.	PCLO NRP2 SCML4 NRXN3 SPINT2	1.13e-04	197	107	5	4961f66606f08e399508fd6cabca588e7ab406a8
ToppCell	normal_Lung-Epithelial_cells-Club\|Epithelial_cells / Location, Cell class and cell subclass	CYP2A6 CYP2A13 PHLDA2 GRHL1 RIMS1	1.16e-04	198	107	5	a9d0109ca05eb3e9c588f9677ec471dd5c092a75
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PCLO ITPR1 FRY NRXN3 RIMS1	1.16e-04	198	107	5	4ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCell	Biopsy_IPF-Epithelial-SCGB3A2+_SCGB1A1+\|Biopsy_IPF / Sample group, Lineage and Cell type	CYP2A6 CYP2A13 PHLDA2 GRHL1 RIMS1	1.19e-04	199	107	5	c6150f5fe2ce4466149a4d553acb907034a72efb
ToppCell	(09)_Interm._secr.>cil.-(2)_GFP_FOXI1\|(09)_Interm._secr.>cil. / shred by cell type by condition	TANC2 TPR BCLAF1 C17orf58 RLIM	1.19e-04	199	107	5	fc680f85ebd3bab4c72876a19a461b0afb5f51ce
ToppCell	NS-control-d_0-4-Epithelial-Secretory\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	LAMP1 HP1BP3 KIAA1217 NKTR RIMS1	1.19e-04	199	107	5	32bdfff40fd442b88489c8b0f79af3927a51a03c
ToppCell	(03)_KRT6B+-(2)_GFP_FOXI1\|(03)_KRT6B+ / shred by cell type by condition	TANC2 TPR BCLAF1 PCLO RLIM	1.19e-04	199	107	5	c425e7975f492ed5cfcca022248adb627e1d27d4
ToppCell	control-Epithelial-Secretory\|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	LAMP1 HP1BP3 KIAA1217 NKTR RIMS1	1.19e-04	199	107	5	262e5b8a52c8ddb0b47048c786e8bdb7158e1b9a
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW10-Stem_cells\|GW10 / Sample Type, Dataset, Time_group, and Cell type.	TCF7L2 MCM4 KIAA1217 TCF7L1 TOP2A	1.22e-04	200	107	5	474e6ab48f199315f3cca86b81fdf54e0461b7b8
ToppCell	Neuronal\|World / cells hierarchy compared to all cells using T-Statistic	PCLO FRY NRXN3 PKD1 RIMS1	1.22e-04	200	107	5	48d801219bc771d6c7e151dc88ca4c179988de85
ToppCell	10x5'v1-week_14-16-Endothelial-stroma-sinusoidal_EC\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	NRP2 KIAA1217 MID1 DCHS1 TCF7L1	1.22e-04	200	107	5	ae429f2de652cc1976e63644781197e9ce0e70c8
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW10-Stem_cells-Stem_cells\|GW10 / Sample Type, Dataset, Time_group, and Cell type.	TCF7L2 MCM4 KIAA1217 TCF7L1 TOP2A	1.22e-04	200	107	5	01a29651e9bb64ef7666c6a61ec396eeb88b2816
Disease	cortical surface area measurement	TANC2 TCF7L2 LINC02881 NPAS3 TRIOBP MARCHF7 ST7L C17orf58 MLF2 SPINT2 MDC1 PKD1 AUTS2 TCF7L1	1.42e-04	1345	98	14	EFO_0010736
Disease	obesity	TCF7L2 STMND1 PACS1 CRACD NRXN3 KIAA1217	1.57e-04	241	98	6	EFO_0001073
Disease	Opitz GBBB syndrome (implicated_via_orthology)	MID2 MID1	1.62e-04	6	98	2	DOID:0080697 (implicated_via_orthology)
Disease	pack-years measurement, systolic blood pressure	FRY NRXN3 DCHS1	1.97e-04	34	98	3	EFO_0006335, EFO_0006526
Disease	Neurodevelopmental Disorders	TANC2 TCF7L2 ITPR1 RIMS1	2.66e-04	93	98	4	C1535926
Disease	trauma exposure measurement	NPAS3 STMND1 NRP2 SCML4 NRXN3	2.78e-04	172	98	5	EFO_0010703
Disease	total cholesterol measurement, response to escitalopram, response to citalopram	POLR2M RIMS1	3.02e-04	8	98	2	EFO_0004574, EFO_0006329, EFO_0007871
Disease	Inherited neuropathies	ITPR1 SACS SCN9A	3.21e-04	40	98	3	C0598589
Disease	neuroticism measurement, cognitive function measurement	TCF7L2 PCLO ZNF507 STMND1 WDPCP KIAA1217 AUTS2 CPEB1	6.05e-04	566	98	8	EFO_0007660, EFO_0008354
Disease	lobe attachment	CYP2A13 POLR2M TRIL SACS KIAA1217	6.48e-04	207	98	5	EFO_0007667
Disease	tuberculin skin test reactivity measurement, decreased susceptibility to bacterial infection	LINC02881 FRY	7.05e-04	12	98	2	EFO_0008307, EFO_0008322
Disease	chronotype measurement	TANC2 CYP2A6 TCF7L2 CCDC61 HP1BP3 NRXN3 DCHS1 AUTS2 RIMS1 CAMTA1	7.07e-04	882	98	10	EFO_0008328
Disease	Intellectual Disability	TANC2 RTTN GFER PACS1 FRY SACS RLIM	7.39e-04	447	98	7	C3714756
Disease	systolic blood pressure, cigarettes per day measurement	FRY NRXN3	8.32e-04	13	98	2	EFO_0006335, EFO_0006525
Disease	COVID-19, coronary artery disease	LINC02881 IL6R	8.32e-04	13	98	2	EFO_0001645, MONDO_0100096
Disease	DEAFNESS, AUTOSOMAL RECESSIVE (disorder)	TRIOBP TMEM132E	8.32e-04	13	98	2	C1846647
Disease	aspartate aminotransferase measurement	CYP2A6 ARHGEF19 MARCHF7 POLR2M PHLDA2 ST7L ITPR1 GLI1 TCF7L1 TJP3	8.53e-04	904	98	10	EFO_0004736
Disease	autosomal dominant polycystic kidney disease (implicated_via_orthology)	GFER PKD1	9.68e-04	14	98	2	DOID:898 (implicated_via_orthology)
Disease	Schizoaffective disorder-bipolar type	PCLO NRXN3	1.27e-03	16	98	2	EFO_0009965
Disease	rosacea severity measurement	PCLO NRXN3 RIMS1 CAMTA1	1.49e-03	147	98	4	EFO_0009180
Disease	gait measurement	TCF7L2 NPAS3 NRXN3 AUTS2	1.60e-03	150	98	4	EFO_0007680
Disease	facial asymmetry measurement	NPAS3 NRXN3	1.80e-03	19	98	2	EFO_0009751
Disease	heart failure, diabetes mellitus, stroke, atrial fibrillation, mortality, coronary artery disease, cancer	TCF7L2 GRHL1	2.00e-03	20	98	2	EFO_0000275, EFO_0000400, EFO_0000712, EFO_0001645, EFO_0003144, EFO_0004352, MONDO_0004992
Disease	unipolar depression	TCF7L2 PCLO PCARE STMND1 WDPCP ANO8 TRIL PKD1 DCHS1 AUTS2 CAMTA1	2.21e-03	1206	98	11	EFO_0003761
Disease	squamous cell lung carcinoma	CYP2A6 NPAS3 FRY RIMS1	2.26e-03	165	98	4	EFO_0000708
Disease	prostate carcinoma	TANC2 TCF7L2 BCLAF1 WDPCP C17orf58 TAB3 RASSF5 GRHL1 SPINT2	2.87e-03	891	98	9	EFO_0001663
Disease	neuroimaging measurement	TCF7L2 LINC02881 ST7L C17orf58 HP1BP3 NRP2 CBFA2T2 RLIM PKD1 CAMTA1	2.93e-03	1069	98	10	EFO_0004346
Disease	body weight	IPPK TCF7L2 RTTN ITPR1 NRXN3 KIAA1217 DGKK PKD1 AUTS2 SENP6 ZRANB1	3.11e-03	1261	98	11	EFO_0004338
Disease	response to mTOR inhibitor	KAT2B RIMS1	3.12e-03	25	98	2	EFO_0005417
Disease	non-Hodgkins lymphoma	LINC02881 TCF7L1	3.12e-03	25	98	2	EFO_0005952
Disease	coffee consumption measurement	CYP2A6 NPAS3 C17orf58 AUTS2	3.22e-03	182	98	4	EFO_0006781

Protein segments in the cluster

Peptide	Gene	Start	Entry
RENEPDSQGPIQRRS	CEP295NL	146	Q96MC4
QASRREERAPPNSSL	CCDC185	591	Q8N715
PPTREDRASSSRERS	CCDC61	291	Q9Y6R9
STNPELRRPRSEPSN	CAMTA1	1216	Q9Y6Y1
PQASDANREPVAERS	CEP68	81	Q76N32
QRTLDPNSPRDFIDS	CYP2A6	256	P11509
EQRSRGVTDTREPSP	CEP72	391	Q9P209
TSAEARPETRAQPSS	ATG2A	1616	Q2TAZ0
DPEPGSNSDSTRRQR	ANO8	696	Q9HCE9
SRNRKNRSSAVDPEP	HP1BP3	241	Q5SSJ5
DREVQAEQPSSSSPR	RBMX2	176	Q9Y388
SQQEGLSRDRPSPES	RASSF5	171	Q8WWW0
ASSDQRPVVPSSRSR	IPPK	416	Q9H8X2
EEPPLGSRSTNERRQ	ARHGEF19	271	Q8IW93
AQTPRSEDARSSPSQ	MCM4	21	P33991
PRFPRASSEATIREN	DCHS1	2066	Q96JQ0
DPEDINQTSPRRRSR	DGKK	806	Q5KSL6
ERSSPAGRDPTRQDA	LDLRAD2	251	Q5SZI1
LPRTNTPARASEARS	LRP10	566	Q7Z4F1
TPEPTSQATRGRTDR	MDC1	1466	Q14676
RDQAEEEPNRIPSRS	MDC1	1866	Q14676
EAPSQRRLRSPNDDI	KAT2B	261	Q92831
PSVDPDQDASRSRLR	ITPR1	331	Q14643
RAPPRSAAASEDARQ	FOXD4L4	91	Q8WXT5
RAPPRSAAASEDARQ	FOXD4L3	91	Q6VB84
AQAENRASPRREPAS	C17orf58	106	Q2M2W7
RSQSADAPGPTERER	HOMER3	156	Q9NSC5
RESEPRPTSARQLDG	ECHDC3	41	Q96DC8
PSPERREENSFDRDT	CBFA2T2	236	O43439
SSESENSPVPQRKRR	PCLO	1516	Q9Y6V0
TARDAEPSSETRPQE	NAT16	21	Q8N8M0
RPRRPSQEQSASASS	FKBP15	951	Q5T1M5
SSSSPNDRTFPDDRN	NRP2	671	O60462
PANDRPSTRSDRLAV	NRXN3	1106	Q9Y4C0
SARPNSTSSREAEPR	AUTS2	951	Q8WXX7
TRRASDPAQAADRPA	GLI1	636	P08151
QAREGPSRETSPREA	TUBGCP4	431	Q9UGJ1
ESQQSESPPRRDSLA	KLC3	161	Q6P597
KVQPSDRAPDSRRTS	GGN	16	Q86UU5
ERRRRPESSSSPESS	HOXA11	211	P31270
PQAETREAREAARSP	NOC2L	36	Q9Y3T9
PLSERTNSSDSERSP	PACS1	521	Q6VY07
QKQASSRSRSEPPRE	RIMS1	256	Q86UR5
RDQDRESPSTRPSTP	PLEKHG6	531	Q3KR16
SRASSPLPRQDRDSF	WDPCP	16	O95876
NTSSHNRPDARDPRS	IL6R	441	P08887
APNAQRRTPDSTFSE	GRHL1	201	Q9NZI5
QRTLDPNSPRDFIDS	CYP2A13	256	Q16696
PRRKRQPSSSSEDSD	CUSTOS	141	Q96C57
ETNSSARPARRAPDE	FAM83C	611	Q9BQN1
DRRPDTTAPLTDRQT	COG3	26	Q96JB2
APQNAPRDESRGRSS	BCLAF1	306	Q9NYF8
SDPRSSERDQLRPGD	CRACD	681	Q6ZU35
PRRQRSDQDSDSDQP	CTR9	1076	Q6PD62
SRSNVPSASEVPDNR	MARCHF7	326	Q9H992
RGETRCEQDRPSPTT	LAMP1	186	P11279
SNFVRSPSQRLDPSR	CPEB1	416	Q9BZB8
IDRSSDPPRSATLDR	FRY	1991	Q5TBA9
PQDNPSSRDDRGRVR	GJA3	126	Q9Y6H8
SSNRDRVPPSSEASE	POLR2M	156	P0CAP2
AEDDIQPSPRRARSS	HPS1	251	Q92902
SRPEESSQSRDSAPS	SACS	4246	Q9NZJ4
AIQGPEDSPSRQSRR	MLF2	231	Q15773
RLRSPRDSQTEPQND	PRR23D1	6	E9PI22
NGSEPESRSPDNRTQ	PKD1	621	P98161
SSPADRESPFQARTR	PCARE	516	A6NGG8
PNTTGSSRREAPRDV	INAFM2	96	P0DMQ5
GAVSPDSRPETRRQT	NRAC	6	Q8N912
RAPSRTSQDRDPSSL	RTTN	1531	Q86VV8
DVAPSSRPAQRSASR	TATDN2	31	Q93075
RDQAEDPASSPTSKR	TMEM132E	996	Q6IEE7
RTGSTQSPRTQPRDE	TAB3	666	Q8N5C8
PRNQESSSDEQTPSR	NKTR	1291	P30414
QTPSRDDDSQSRSPS	NKTR	1301	P30414
PANDRPSTRSDRLAV	NRXN3	101	Q9HDB5
RAPPRSAAASEDARQ	FOXD4L5	91	Q5VV16
RAPPRSAAASEDARQ	FOXD4L6	91	Q3SYB3
ERRSSNISQASRSPP	SCN9A	596	Q15858
ARSQPEDTPENTVRR	KIAA1217	1626	Q5T5P2
REQRASREPEPGSAS	SMIM41	71	A0A2R8YCJ5
SEEPPDRRQSSVDSR	TANC2	26	Q9HCD6
PSFQQDPSRRERITA	NPAS3	6	Q8IXF0
PTDSNNSTPREAASR	SSC5D	416	A1L4H1
RLRSPRDSQTEPQND	PRR23D2	6	P0DMB1
RASSPSRSTQLDNPR	TRIOBP	341	Q9H2D6
DDPRASSPNRTTQRE	TRIOBP	386	Q9H2D6
DNPRASSPSRATRDN	TRIOBP	436	Q9H2D6
TSSPNRATRDNPRTS	TRIOBP	466	Q9H2D6
ASRTSSPNRATRDNP	TRIOBP	561	Q9H2D6
RASSPNRATRDNPTT	TRIOBP	586	Q9H2D6
DNPRASRTSSPNRAT	TRIOBP	606	Q9H2D6
AQRDDPRASSPNRTT	TRIOBP	701	Q9H2D6
DNPRTSSPNRATRDN	TRIOBP	776	Q9H2D6
TSDSPVAEDASRRRP	GFER	56	P55789
PRPRQDSAAGNSEER	LINC02881	31	B7Z368
ESEPTSRRQCRNSPG	ZSCAN32	456	Q9NX65
PRTSNRERSDSQPRN	SRRM5	176	B3KS81
QSSSSDSEAERRPQP	TCF7L1	76	Q9HCS4
EQQPSSASERQAPRA	TPR	2056	P12270
ADSSVPSAPRRQDSE	SPINT2	106	O43291
AADASRRPDSRPVRS	PPM1M	46	Q96MI6
VENPRSESTSARPSR	RLIM	176	Q9NVW2
TRAPRSSSQEQEPSA	TECPR1	1141	Q7Z6L1
VSGPNSPSETRRERA	MID1	91	O15344
DPSPSASLTADRRRQ	TRIL	416	Q7L0X0
QNSSSDSEAERRPPP	TCF7L2	56	Q9NQB0
NAEPADRDSPRTARQ	UAP1L1	411	Q3KQV9
DNDRTNRRESISPQP	SENP6	341	Q9GZR1
SEPGSPSRNRENETS	ST7L	131	Q8TDW4
IDRSDLSPRASPENR	VN1R4	216	Q7Z5H5
RSRQERTAPAAPAED	PHLDA2	111	Q53GA4
RSSDESNFDVPPRET	TOP2A	1301	P11388
SEPVQADESQSPRDR	TJP3	846	O95049
ENAPPGRRRTNSESL	ZNF507	476	Q8TCN5
SENSPSPSERNRRVN	STMND1	71	H3BQB6
RLQSRSRPSAPETDD	TOGARAM1	21	Q9Y4F4
VSGPNSPSESRRERT	MID2	111	Q9UJV3
RAPDSRPEEALDSSR	TMEM119	156	Q4V9L6
DNSARDSLRISDPSP	THEGL	291	P0DJG4
SSPSQDAQDARRPRS	SCML4	326	Q8N228
DAQDARRPRSRNPSA	SCML4	331	Q8N228
NSQRRSPPATKRDSE	ZRANB1	211	Q9UGI0
PRTTAVSSNRNPEDD	nan	271	Q8N7P7