Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionK63-linked polyubiquitin modification-dependent protein binding

IKBKG TNFAIP3 ZRANB3

1.15e-0426733GO:0070530
GeneOntologyMolecularFunctionneuregulin binding

ERBB3 ITGB3

1.96e-046732GO:0038132
GeneOntologyMolecularFunctionubiquitin-protein transferase activity

CUL5 TRIM49 TRIM51 TRIM49C TNFAIP3 RFPL1 RFPL3 RFPL2

3.26e-04473738GO:0004842
GeneOntologyMolecularFunctionubiquitin-like protein transferase activity

CUL5 TRIM49 TRIM51 TRIM49C TNFAIP3 RFPL1 RFPL3 RFPL2

5.51e-04512738GO:0019787
GeneOntologyMolecularFunctionaminoacyltransferase activity

CUL5 TRIM49 TRIM51 TRIM49C TNFAIP3 RFPL1 RFPL3 RFPL2

7.08e-04532738GO:0016755
GeneOntologyMolecularFunctionkinase binding

CDK9 TRIM49 TRIM51 EGFR POLA1 TRIM49C TNFAIP3 RFPL1 ITGB3 RFPL3 RFPL2

7.48e-049697311GO:0019900
GeneOntologyMolecularFunctioninsulin-like growth factor I binding

LRP2 ITGB3

1.00e-0313732GO:0031994
GeneOntologyMolecularFunctionprotein kinase binding

CDK9 TRIM49 TRIM51 EGFR POLA1 TRIM49C RFPL1 ITGB3 RFPL3 RFPL2

1.24e-038737310GO:0019901
GeneOntologyMolecularFunctionpolyubiquitin modification-dependent protein binding

IKBKG TNFAIP3 ZRANB3

1.32e-0359733GO:0031593
GeneOntologyMolecularFunctionzinc ion binding

PAPPA2 TRIM49 USP49 TRIM51 ADAMTS9 POLA1 ESRRB TRIM49C TNFAIP3 ZRANB3

1.44e-038917310GO:0008270
GeneOntologyMolecularFunctioninsulin-like growth factor binding

LRP2 ITGB3

2.17e-0319732GO:0005520
GeneOntologyMolecularFunctioncoreceptor activity

GPC4 GPC6 ITGB3

2.33e-0372733GO:0015026
GeneOntologyMolecularFunctionubiquitin protein ligase activity

TRIM49 TRIM51 TRIM49C RFPL1 RFPL3 RFPL2

2.39e-03372736GO:0061630
GeneOntologyMolecularFunctiongrowth factor binding

ERBB3 EGFR LRP2 ITGB3

2.57e-03156734GO:0019838
GeneOntologyCellularComponentmicrofibril

THSD4 FBN1 FBN3

1.24e-0513753GO:0001527
GeneOntologyCellularComponentfemale germ cell nucleus

RFPL1 RFPL3 RFPL2

1.85e-0431753GO:0001674
MousePhenoabnormal aortic sinus morphology

THSD4 FBN1

1.69e-052582MP:0010482
MousePhenoabnormal skin appearance

CUL5 PDS5B FBN1 PNPLA6 EGFR FSHR IKBKG GRN ITGB3 PROS1

2.17e-054735810MP:0009931
MousePhenoabsent cerebellum vermis

ERBB3 ZNF423

5.06e-053582MP:0000865
MousePhenoabnormal cerebellar plate morphology

ERBB3 ZNF423

5.06e-053582MP:0000856
MousePhenoabnormal trophoblast giant cell morphology

PNPLA6 EGFR ESRRB TRRAP ITGB3

7.59e-05106585MP:0005033
MousePhenoabnormal mural trophectoderm morphology

PNPLA6 EGFR ESRRB TRRAP ITGB3

7.94e-05107585MP:0012057
MousePhenoabnormal hindlimb morphology

PAPPA2 FLNC FBN1 HOXC10 SCUBE2 ACADM EGFR FSHR TSHR GPC6

1.14e-045765810MP:0000556
MousePhenoabnormal respiration

PDS5B FLNC TSHZ3 ERBB3 FBN1 EGFR SFTPC FAT3 ISM1 LRP2

1.55e-045985810MP:0001943
MousePhenocardiac valve regurgitation

ERBB3 FBN1 EGFR

1.65e-0426583MP:0009384
MousePhenodecreased femur size

PAPPA2 HOXC10 SCUBE2 FSHR GPC6

1.99e-04130585MP:0030825
MousePhenoabnormal skin morphology

CUL5 PDS5B ENKUR FBN1 PNPLA6 EGFR ADAMTS9 OTOGL FAT3 FSHR MAP3K9 IKBKG GRN TNFAIP3 ITGB3 PROS1

2.01e-0414555816MP:0002060
MousePhenoabnormal femur morphology

PAPPA2 HOXC10 SCUBE2 FSHR TSHR GPC6

2.50e-04214586MP:0000559
MousePhenoincreased thyrotroph cell number

FSHR TSHR

2.51e-046582MP:0008337
MousePhenouterine hemorrhage

FSHR ITGB3

2.51e-046582MP:0004898
MousePhenoabnormal heart valve physiology

ERBB3 FBN1 EGFR

2.54e-0430583MP:0011926
MousePhenoabnormal uterus physiology

FSHR TNFAIP3 ITGB3

2.54e-0430583MP:0009671
MousePhenoabnormal vagina orifice morphology

EGFR FSHR LRP2

2.54e-0430583MP:0001142
MousePhenoabnormal hindlimb stylopod morphology

PAPPA2 HOXC10 SCUBE2 FSHR TSHR GPC6

2.57e-04215586MP:0003856
MousePhenoabnormal extraembryonic tissue morphology

FLNC NANOGP8 FBN1 PNPLA6 EGFR ADAMTS9 ESRRB LRP2 TRRAP ITGB3 ZFY PROS1

2.90e-049085812MP:0002086
MousePhenoabnormal uterine environment

FSHR TSHR ITGB3

4.04e-0435583MP:0004014
MousePhenoabnormal telencephalon morphology

ZNF597 ERBB3 EGFR ZNF423 FSHR LRP2 GRN POGZ SSPOP WDR62 PROS1

4.38e-048125811MP:0000787
MousePhenoabnormal cartilage morphology

FBN1 HOXC10 SCUBE2 EGFR KIAA1217 TSHR GPC6

4.57e-04336587MP:0000163
MousePhenooverexpanded pulmonary alveolus

FBN1 SFTPC LRP2

4.76e-0437583MP:0001183
MousePhenoemphysema

FBN1 SFTPC LRP2

4.76e-0437583MP:0001958
MousePhenolimbs/digits/tail phenotype

PAPPA2 PDS5B FLNC FBN1 HOXC10 SCUBE2 ACADM EGFR ADAMTS9 KIAA1217 FSHR LRP2 TSHR GPC6

4.93e-0412585814MP:0005371
MousePhenoabnormal limb long bone morphology

PAPPA2 PDS5B FBN1 HOXC10 SCUBE2 ACADM FSHR TSHR GPC6

5.09e-04568589MP:0011504
MousePhenoabnormal trophectoderm morphology

PNPLA6 EGFR ESRRB TRRAP ITGB3

5.18e-04160585MP:0005028
MousePhenoabnormal aorta tunica media morphology

THSD4 FBN1 ACADM

5.57e-0439583MP:0009873
MousePhenoabnormal aorta bulb morphology

THSD4 FBN1

5.98e-049582MP:0011572
MousePhenoabsent nasal septum

LRP2 GPC6

5.98e-049582MP:0004872
MousePhenoshort radius

PAPPA2 PDS5B FBN1

6.01e-0440583MP:0004355
MousePhenodecreased radius size

PAPPA2 PDS5B FBN1

6.01e-0440583MP:0030886
MousePhenoabnormal limb bone morphology

PAPPA2 PDS5B FBN1 HOXC10 SCUBE2 ACADM FSHR TSHR GPC6

6.45e-04587589MP:0002115
MousePhenodecreased respiration

FLNC ERBB3 FBN1 EGFR LRP2

6.83e-04170585MP:0014274
MousePhenoabnormal blastocyst morphology

NANOGP8 PNPLA6 EGFR ESRRB TRRAP ITGB3

6.90e-04259586MP:0004957
MousePhenoabnormal epidermal pigmentation

ADAMTS9 IKBKG

7.45e-0410582MP:0009387
MousePhenoabnormal cerebral hemisphere morphology

ERBB3 EGFR ZNF423 FSHR LRP2 GRN POGZ WDR62 PROS1

7.46e-04599589MP:0008540
MousePhenoabnormal parietal yolk sac morphology

PNPLA6 EGFR ESRRB TRRAP ITGB3

8.19e-04177585MP:0011203
MousePhenoshort ulna

PAPPA2 PDS5B FBN1

9.07e-0446583MP:0004359
MousePhenodecreased ulna size

PAPPA2 PDS5B FBN1

9.07e-0446583MP:0030900
MousePhenopetechiae

EGFR ITGB3

9.08e-0411582MP:0008816
MousePhenoabnormal thrombosis

FBN1 FSHR ITGB3 PROS1

9.68e-04106584MP:0005048
MousePhenoabnormal interleukin-6 secretion

CUL5 USP49 IKBKG GRN TNFAIP3

1.02e-03186585MP:0008704
MousePhenoabnormal choroid plexus morphology

ERBB3 ZNF423 LRP2

1.03e-0348583MP:0000820
MousePhenoabnormal tela choroidea morphology

ERBB3 ZNF423 LRP2

1.03e-0348583MP:0013306
MousePhenoabnormal neocortex morphology

ERBB3 WDR62 PROS1

1.03e-0348583MP:0008547
MousePhenointernal hemorrhage

FBN1 PNPLA6 FSHR MAP3K9 IKBKG ITGB3 PROS1

1.05e-03387587MP:0001634
MousePhenoabnormal preimplantation embryo morphology

NANOGP8 PNPLA6 EGFR ESRRB TRRAP ITGB3

1.09e-03283586MP:0014137
MousePhenoabnormal circulating progesterone level

FSHR TSHR TNFAIP3

1.16e-0350583MP:0005184
MousePhenoabnormal aorta wall morphology

THSD4 FBN1 ACADM

1.16e-0350583MP:0009866
DomainGrowth_fac_rcpt_

ELAPOR2 ERBB3 FBN1 SCUBE2 EGFR LRP2 FBN3 PROS1

1.87e-07156748IPR009030
DomainConA-like_dom

PAPPA2 TRIM49 TRIM51 FAT3 TRIM49C RFPL1 RFPL3 RFPL2 PROS1

2.03e-07219749IPR013320
DomainButyrophylin

TRIM49 TRIM51 TRIM49C RFPL1 RFPL3 RFPL2

3.38e-0770746IPR003879
DomainRDM

RFPL1 RFPL3 RFPL2

5.94e-075743PF11002
DomainRDM_domain_RFPL

RFPL1 RFPL3 RFPL2

5.94e-075743IPR022723
DomainEGF_1

FBN1 SCUBE2 FAT3 LRP2 C7 SSPOP ITGB3 FBN3 PROS1

7.30e-07255749PS00022
DomainEGF_2

FBN1 SCUBE2 FAT3 LRP2 C7 SSPOP ITGB3 FBN3 PROS1

1.01e-06265749PS01186
DomainEGF_CA

FBN1 SCUBE2 FAT3 LRP2 FBN3 PROS1

1.15e-0686746PF07645
DomainSPRY

TRIM49 TRIM51 TRIM49C RFPL1 RFPL3 RFPL2

1.95e-0694746PF00622
DomainSPRY_dom

TRIM49 TRIM51 TRIM49C RFPL1 RFPL3 RFPL2

1.95e-0694746IPR003877
DomainB30.2/SPRY

TRIM49 TRIM51 TRIM49C RFPL1 RFPL3 RFPL2

2.07e-0695746IPR001870
DomainB302_SPRY

TRIM49 TRIM51 TRIM49C RFPL1 RFPL3 RFPL2

2.07e-0695746PS50188
DomainEGF_Ca-bd_CS

FBN1 SCUBE2 FAT3 LRP2 FBN3 PROS1

2.34e-0697746IPR018097
DomainEGF_CA

FBN1 SCUBE2 FAT3 LRP2 FBN3 PROS1

2.64e-0699746PS01187
DomainASX_HYDROXYL

FBN1 SCUBE2 FAT3 LRP2 FBN3 PROS1

2.79e-06100746PS00010
DomaincEGF

FBN1 SCUBE2 LRP2 FBN3

3.18e-0626744IPR026823
DomaincEGF

FBN1 SCUBE2 LRP2 FBN3

3.18e-0626744PF12662
DomainEGF-type_Asp/Asn_hydroxyl_site

FBN1 SCUBE2 FAT3 LRP2 FBN3 PROS1

3.93e-06106746IPR000152
DomainEGF_3

FBN1 SCUBE2 FAT3 LRP2 C7 SSPOP FBN3 PROS1

4.11e-06235748PS50026
DomainTSP_1

THSD4 ADAMTS9 ISM1 C7 SSPOP

5.00e-0663745PF00090
DomainTSP1

THSD4 ADAMTS9 ISM1 C7 SSPOP

5.84e-0665745SM00209
DomainTSP1_rpt

THSD4 ADAMTS9 ISM1 C7 SSPOP

5.84e-0665745IPR000884
DomainTSP1

THSD4 ADAMTS9 ISM1 C7 SSPOP

5.84e-0665745PS50092
DomainEGF_CA

FBN1 SCUBE2 FAT3 LRP2 FBN3 PROS1

8.85e-06122746SM00179
DomainEGF-like_CS

FBN1 SCUBE2 FAT3 LRP2 C7 ITGB3 FBN3 PROS1

8.88e-06261748IPR013032
DomainEGF-like_Ca-bd_dom

FBN1 SCUBE2 FAT3 LRP2 FBN3 PROS1

9.71e-06124746IPR001881
DomainSPRY

TRIM49 TRIM49C RFPL1 RFPL3 RFPL2

2.44e-0587745SM00449
DomainFBN

FBN1 FBN3

4.63e-053742IPR011398
DomainEGF-like_dom

FBN1 SCUBE2 FAT3 LRP2 C7 FBN3 PROS1

5.79e-05249747IPR000742
DomainTyr_kinase_EGF/ERB/XmrK_rcpt

ERBB3 EGFR

9.24e-054742IPR016245
DomainEGF

SCUBE2 LRP2 ITGB3 FBN3 PROS1

1.43e-04126745PF00008
DomainGLYPICAN

GPC4 GPC6

2.30e-046742PS01207
DomainGlypican

GPC4 GPC6

2.30e-046742IPR001863
DomainGF_recep_IV

ERBB3 EGFR

2.30e-046742PF14843
DomainGF_recep_IV

ERBB3 EGFR

2.30e-046742IPR032778
DomainGlypican

GPC4 GPC6

2.30e-046742PF01153
DomainGphrmn_rcpt_fam

FSHR TSHR

2.30e-046742IPR002131
DomainGlypican_CS

GPC4 GPC6

2.30e-046742IPR019803
DomainFurin-like

ERBB3 EGFR

3.21e-047742PF00757
DomainRcpt_L-dom

ERBB3 EGFR

3.21e-047742IPR000494
DomainTB

FBN1 FBN3

3.21e-047742PF00683
DomainFurin-like_Cys-rich_dom

ERBB3 EGFR

3.21e-047742IPR006211
DomainRecep_L_domain

ERBB3 EGFR

3.21e-047742PF01030
Domain-

ERBB3 EGFR

3.21e-0477423.80.20.20
DomainEGF

FBN1 SCUBE2 FAT3 LRP2 FBN3 PROS1

3.38e-04235746SM00181
Domain-

TRIM49 USP49 TRIM51 ZNF423 TRIM49C RFPL1 RFPL3 RFPL2

3.94e-044497483.30.40.10
Domain-

FBN1 FBN3

4.27e-0487423.90.290.10
DomainZnf_RING/FYVE/PHD

TRIM49 USP49 TRIM51 ZNF423 TRIM49C RFPL1 RFPL3 RFPL2

4.56e-04459748IPR013083
DomainLDLR_class-A_CS

LRP2 C7 SSPOP

5.31e-0440743IPR023415
DomainTB

FBN1 FBN3

5.48e-049742PS51364
DomainTB_dom

FBN1 FBN3

5.48e-049742IPR017878
DomainPRY

RFPL1 RFPL3 RFPL2

6.13e-0442743PF13765
DomainLRR_5

FSHR TSHR

6.83e-0410742PF13306
DomainLRR_5

FSHR TSHR

6.83e-0410742IPR026906
DomainLdl_recept_a

LRP2 C7 SSPOP

7.52e-0445743PF00057
Domain-

LRP2 C7 SSPOP

8.02e-04467434.10.400.10
DomainPRY

RFPL1 RFPL3 RFPL2

9.09e-0448743SM00589
DomainLDLRA_1

LRP2 C7 SSPOP

9.09e-0448743PS01209
DomainPRY

RFPL1 RFPL3 RFPL2

9.09e-0448743IPR006574
DomainLDLRA_2

LRP2 C7 SSPOP

9.65e-0449743PS50068
DomainLDrepeatLR_classA_rpt

LRP2 C7 SSPOP

9.65e-0449743IPR002172
DomainLDLa

LRP2 C7 SSPOP

9.65e-0449743SM00192
DomainZF_RING_1

TRIM49 TRIM51 TRIM49C RFPL1 RFPL3 RFPL2

1.04e-03291746PS00518
DomainZF_RING_2

TRIM49 TRIM51 TRIM49C RFPL1 RFPL3 RFPL2

1.17e-03298746PS50089
DomainRING

TRIM49 TRIM51 TRIM49C RFPL1 RFPL3 RFPL2

1.32e-03305746SM00184
DomainTIL_dom

LRP2 SSPOP

1.37e-0314742IPR002919
Domainzf-C2H2

ZNF597 TSHZ3 ZNF423 ZKSCAN3 POGZ ZNF30 ZFY ZNF239 ZNF71

1.62e-03693749PF00096
DomainZnf_RING

TRIM49 TRIM51 TRIM49C RFPL1 RFPL3 RFPL2

1.85e-03326746IPR001841
DomainL_dom-like

ERBB3 EGFR FBXL8 FSHR TSHR LRRC74A

1.91e-03328746IPR032675
DomainFurin_repeat

ERBB3 EGFR

2.27e-0318742IPR006212
DomainFU

ERBB3 EGFR

2.27e-0318742SM00261
DomainBBOX

TRIM49 TRIM51 TRIM49C

2.59e-0369743SM00336
Domain-

TRIM49 TRIM51 TRIM49C

2.81e-03717434.10.45.10
Domainzf-B_box

TRIM49 TRIM51 TRIM49C

2.93e-0372743PF00643
DomainZINC_FINGER_C2H2_2

ZNF597 TSHZ3 ZNF423 ZKSCAN3 POGZ ZNF30 ZFY ZNF239 ZNF71

3.45e-03775749PS50157
DomainZINC_FINGER_C2H2_1

ZNF597 TSHZ3 ZNF423 ZKSCAN3 POGZ ZNF30 ZFY ZNF239 ZNF71

3.51e-03777749PS00028
DomainADAM_spacer1

THSD4 ADAMTS9

3.71e-0323742IPR010294
DomainADAM_spacer1

THSD4 ADAMTS9

3.71e-0323742PF05986
DomainZF_BBOX

TRIM49 TRIM51 TRIM49C

3.94e-0380743PS50119
PathwayREACTOME_RESPIRATORY_SYNCYTIAL_VIRUS_RSV_ATTACHMENT_AND_ENTRY

EGFR GPC4 GPC6

8.43e-0523533M48234
PathwayPID_NFKAPPAB_CANONICAL_PATHWAY

IKBKG TNFAIP3 SSPOP

8.43e-0523533M37
PathwayBIOCARTA_ERBB3_PATHWAY

ERBB3 EGFR

1.38e-045532M22018
PathwayREACTOME_DOWNREGULATION_OF_ERBB2_SIGNALING

CUL5 ERBB3 EGFR

1.71e-0429533M27756
PathwayREACTOME_DISEASES_OF_GLYCOSYLATION

THSD4 ADAMTS9 GPC4 GPC6 SSPOP

1.94e-04143535M27275
PathwayBIOCARTA_ERBB3_PATHWAY

ERBB3 EGFR

2.06e-046532MM1543
PathwayPID_ARF6_PATHWAY

EGFR TSHR ITGB3

3.02e-0435533M86
PathwayREACTOME_DISEASES_OF_METABOLISM

THSD4 ADAMTS9 SFTPC GPC4 GPC6 SSPOP

3.35e-04250536M27554
PathwayREACTOME_MOLECULES_ASSOCIATED_WITH_ELASTIC_FIBRES

FBN1 ITGB3 FBN3

3.56e-0437533M27134
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

THSD4 ADAMTS9 SSPOP

4.17e-0439533M27417
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

THSD4 ADAMTS9 SSPOP

4.17e-0439533MM15165
PathwayWP_COMPLEMENT_SYSTEM

LRP2 C7 ITGB3 PROS1

4.58e-0496534M39581
PathwayREACTOME_ELASTIC_FIBRE_FORMATION

FBN1 ITGB3 FBN3

5.96e-0444533M26969
PathwayREACTOME_METABOLISM_OF_FAT_SOLUBLE_VITAMINS

GPC4 LRP2 GPC6

6.37e-0445533MM15344
PathwayREACTOME_ERBB2_ACTIVATES_PTK6_SIGNALING

ERBB3 EGFR

7.46e-0411532MM15478
PathwayREACTOME_METABOLISM_OF_FAT_SOLUBLE_VITAMINS

GPC4 LRP2 GPC6

7.70e-0448533M27642
PathwayREACTOME_SIGNALING_BY_ERBB2

CUL5 ERBB3 EGFR

8.68e-0450533M553
PathwayREACTOME_HORMONE_LIGAND_BINDING_RECEPTORS

FSHR TSHR

8.94e-0412532M13070
PathwayREACTOME_ERBB2_ACTIVATES_PTK6_SIGNALING

ERBB3 EGFR

1.05e-0313532M27729
PathwayREACTOME_ERBB2_REGULATES_CELL_MOTILITY

ERBB3 EGFR

1.05e-0313532MM15320
PathwayREACTOME_RESPIRATORY_SYNCYTIAL_VIRUS_INFECTION_PATHWAY

CUL5 EGFR GPC4 GPC6

1.06e-03120534M48233
PathwayBIOCARTA_CD40_PATHWAY

IKBKG TNFAIP3

1.23e-0314532MM1362
PathwayREACTOME_DEFECTIVE_EXT2_CAUSES_EXOSTOSES_2

GPC4 GPC6

1.23e-0314532M27263
PathwayKEGG_MEDICUS_REFERENCE_EGF_EGFR_PI3K_NFKB_SIGNALING_PATHWAY

EGFR IKBKG

1.23e-0314532M47536
PathwayREACTOME_PI3K_EVENTS_IN_ERBB2_SIGNALING

ERBB3 EGFR

1.23e-0314532MM14761
PathwayREACTOME_SHC1_EVENTS_IN_ERBB2_SIGNALING

ERBB3 EGFR

1.23e-0314532MM14531
PathwayPID_ERBB_NETWORK_PATHWAY

ERBB3 EGFR

1.41e-0315532M201
PathwayBIOCARTA_CD40_PATHWAY

IKBKG TNFAIP3

1.41e-0315532M16697
PathwayREACTOME_ERBB2_REGULATES_CELL_MOTILITY

ERBB3 EGFR

1.41e-0315532M27608
PathwayREACTOME_HORMONE_LIGAND_BINDING_RECEPTORS

FSHR TSHR

1.41e-0315532MM14972
PathwayWP_MODULATORS_OF_TCR_SIGNALING_AND_T_CELL_ACTIVATION

CUL5 IKBKG TNFAIP3

1.55e-0361533M42548
Pubmed

Induction of PGRN by influenza virus inhibits the antiviral immune responses through downregulation of type I interferons signaling.

IKBKG GRN TNFAIP3

9.63e-09375331585000
Pubmed

Evolutionary forces shape the human RFPL1,2,3 genes toward a role in neocortex development.

RFPL1 RFPL3 RFPL2

9.63e-09375318656177
Pubmed

Duplications on human chromosome 22 reveal a novel Ret Finger Protein-like gene family with sense and endogenous antisense transcripts.

RFPL1 RFPL3 RFPL2

9.60e-08575310508838
Pubmed

The ret finger protein-like 4 gene, Rfpl4, encodes a putative E3 ubiquitin-protein ligase expressed in adult germ cells.

RFPL1 RFPL3 RFPL2

9.60e-08575311850190
Pubmed

Stretch-induced fetal type II cell differentiation is mediated via ErbB1-ErbB4 interactions.

ERBB3 EGFR SFTPC

3.35e-07775322493501
Pubmed

RFPL4 interacts with oocyte proteins of the ubiquitin-proteasome degradation pathway.

RFPL1 RFPL3 RFPL2

5.35e-07875312525704
Pubmed

Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.

CDK9 TRIM49 ERBB3 EGFR FBXL8 MAP3K9 TNFAIP3 PRAG1

1.44e-0637275822939624
Pubmed

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.

ERBB3 EGFR LRP2 TSHR ITGB3

2.75e-0610175523382219
Pubmed

Trim43a, Trim43b, and Trim43c: Novel mouse genes expressed specifically in mouse preimplantation embryos.

TRIM49 TRIM51 TRIM49C

4.30e-061575319703589
Pubmed

EGFR Transgene Stimulates Spontaneous Formation of MCF7 Breast Cancer Cells Spheroids with Partly Loss of HER3 Receptor.

ERBB3 EGFR

4.59e-06275234884742
Pubmed

Fibroblast A20 governs fibrosis susceptibility and its repression by DREAM promotes fibrosis in multiple organs.

FBN1 TNFAIP3

4.59e-06275236289219
Pubmed

ErbB3 expression promotes tumorigenesis in pancreatic adenocarcinoma.

ERBB3 EGFR

4.59e-06275220647770
Pubmed

Pathogenic HER3 dimerization domain mutations create a structural bias towards un-conventional EGFR-HER3 signalling axis in breast cancer.

ERBB3 EGFR

4.59e-06275237156315
Pubmed

Thyrostimulin-TSHR signaling promotes the proliferation of NIH:OVCAR-3 ovarian cancer cells via trans-regulation of the EGFR pathway.

EGFR TSHR

4.59e-06275227273257
Pubmed

Safety and Pharmacokinetics/Pharmacodynamics of the First-in-Class Dual Action HER3/EGFR Antibody MEHD7945A in Locally Advanced or Metastatic Epithelial Tumors.

ERBB3 EGFR

4.59e-06275226034219
Pubmed

EGFR transactivation contributes to neuroinflammation in Streptococcus suis meningitis.

ERBB3 EGFR

4.59e-06275227756321
Pubmed

Expression and Prognostic Significance of Human Epidermal Growth Factor Receptors 1 and 3 in Gastric and Esophageal Adenocarcinoma.

ERBB3 EGFR

4.59e-06275226844548
Pubmed

Influence of the hinge region and its adjacent domains on binding and signaling patterns of the thyrotropin and follitropin receptor.

FSHR TSHR

4.59e-06275225340405
Pubmed

ADAMTSL6β protein rescues fibrillin-1 microfibril disorder in a Marfan syndrome mouse model through the promotion of fibrillin-1 assembly.

THSD4 FBN1

4.59e-06275221880733
Pubmed

Combined HER3-EGFR score in triple-negative breast cancer provides prognostic and predictive significance superior to individual biomarkers.

ERBB3 EGFR

4.59e-06275232080212
Pubmed

EGFR and HER3 expression in circulating tumor cells and tumor tissue from non-small cell lung cancer patients.

ERBB3 EGFR

4.59e-06275231092882
Pubmed

Epigallocatechin gallate has pleiotropic effects on transmembrane signaling by altering the embedding of transmembrane domains.

EGFR ITGB3

4.59e-06275228487468
Pubmed

Biophysical Evidence for Intrinsic Disorder in the C-terminal Tails of the Epidermal Growth Factor Receptor (EGFR) and HER3 Receptor Tyrosine Kinases.

ERBB3 EGFR

4.59e-06275227872189
Pubmed

An HER3-targeting antibody-drug conjugate incorporating a DNA topoisomerase I inhibitor U3-1402 conquers EGFR tyrosine kinase inhibitor-resistant NSCLC.

ERBB3 EGFR

4.59e-06275230302022
Pubmed

Three novel mutations of the fibrillin-1 gene and ten single nucleotide polymorphisms of the fibrillin-3 gene in Marfan syndrome patients.

FBN1 FBN3

4.59e-06275215221638
Pubmed

Asymmetric kinase dimer formation is crucial for the activation of oncogenic EGFRvIII but not for ERBB3 phosphorylation.

ERBB3 EGFR

4.59e-06275223758840
Pubmed

Structure of the integrin binding fragment from fibrillin-1 gives new insights into microfibril organization.

FBN1 ITGB3

4.59e-06275215062093
Pubmed

ErbB3 mRNA expression correlated with specific clinicopathologic features of Japanese lung cancers.

ERBB3 EGFR

4.59e-06275217631905
Pubmed

EGFR and HER3 mRNA expression levels predict distant metastases in locally advanced rectal cancer.

ERBB3 EGFR

4.59e-06275220824716
Pubmed

Dual Targeting of Epidermal Growth Factor Receptor and HER3 by MEHD7945A as Monotherapy or in Combination with Cisplatin Partially Overcomes Cetuximab Resistance in Head and Neck Squamous Cell Carcinoma Cell Lines.

ERBB3 EGFR

4.59e-06275228910149
Pubmed

EGFR family-mediated signal transduction in the human keratinocyte cell line HaCaT.

ERBB3 EGFR

4.59e-06275210527633
Pubmed

Contribution of EGFR and ErbB-3 Heterodimerization to the EGFR Mutation-Induced Gefitinib- and Erlotinib-Resistance in Non-Small-Cell Lung Carcinoma Treatments.

ERBB3 EGFR

4.59e-06275225993617
Pubmed

Hepatocyte ERBB3 and EGFR are required for maximal CCl4-induced liver fibrosis.

ERBB3 EGFR

4.59e-06275227586651
Pubmed

Antagonism of EGFR and HER3 enhances the response to inhibitors of the PI3K-Akt pathway in triple-negative breast cancer.

ERBB3 EGFR

4.59e-06275224667376
Pubmed

Loss of hepatocyte ERBB3 but not EGFR impairs hepatocarcinogenesis.

ERBB3 EGFR

4.59e-06275226492920
Pubmed

Integrin-modulating therapy prevents fibrosis and autoimmunity in mouse models of scleroderma.

FBN1 ITGB3

4.59e-06275224107997
Pubmed

ADAMTSL-6 is a novel extracellular matrix protein that binds to fibrillin-1 and promotes fibrillin-1 fibril formation.

THSD4 FBN1

4.59e-06275219940141
Pubmed

Hydrogen bond analysis of the EGFR-ErbB3 heterodimer related to non-small cell lung cancer and drug resistance.

ERBB3 EGFR

4.59e-06275230593826
Pubmed

Lineage-specific biology revealed by a finished genome assembly of the mouse.

TRIM49 TRIM51 TRIM49C FER1L5

6.26e-065575419468303
Pubmed

Fibulin-1 is required during cardiac ventricular morphogenesis for versican cleavage, suppression of ErbB2 and Erk1/2 activation, and to attenuate trabecular cardiomyocyte proliferation.

ERBB3 EGFR ADAMTS9

6.41e-061775322183742
Pubmed

Identification of a genomic reservoir for new TRIM genes in primate genomes.

TRIM49 TRIM51 TRIM49C

9.10e-061975322144910
Pubmed

Betacellulin (BTC) Biases the EGFR To Dimerize with ErbB3.

ERBB3 EGFR

1.37e-05375230249613
Pubmed

Growth stimulation of non-small cell lung cancer cell lines by antibody against epidermal growth factor receptor promoting formation of ErbB2/ErbB3 heterodimers.

ERBB3 EGFR

1.37e-05375217426253
Pubmed

Expression and Prognostic Significance of Human Epidermal Growth Factor Receptors 1, 2 and 3 in Periampullary Adenocarcinoma.

ERBB3 EGFR

1.37e-05375227070783
Pubmed

Profiling epidermal growth factor receptor and heregulin receptor 3 heteromerization using receptor tyrosine kinase heteromer investigation technology.

ERBB3 EGFR

1.37e-05375223700486
Pubmed

A central role for HER3 in HER2-amplified breast cancer: implications for targeted therapy.

ERBB3 EGFR

1.37e-05375218632642
Pubmed

ErbB receptor signaling directly controls oligodendrocyte progenitor cell transformation and spontaneous remyelination after spinal cord injury.

ERBB3 EGFR

1.37e-05375230637799
Pubmed

Tyrosine sulfation is required for agonist recognition by glycoprotein hormone receptors.

FSHR TSHR

1.37e-05375211847099
Pubmed

Expression and prognostic significance of human epidermal growth factor receptors 1, 2 and 3 in oesophageal and gastric adenocarcinomas preneoadjuvant and postneoadjuvant treatment.

ERBB3 EGFR

1.37e-05375229138285
Pubmed

Protein secretion in human mammary epithelial cells following HER1 receptor activation: influence of HER2 and HER3 expression.

ERBB3 EGFR

1.37e-05375221320340
Pubmed

Glycoprotein hormone receptors: link between receptor homodimerization and negative cooperativity.

FSHR TSHR

1.37e-05375215889138
Pubmed

A new model system identifies epidermal growth factor receptor-human epidermal growth factor receptor 2 (HER2) and HER2-human epidermal growth factor receptor 3 heterodimers as potent inducers of oesophageal epithelial cell invasion.

ERBB3 EGFR

1.37e-05375228940194
Pubmed

Astrocyte glypicans 4 and 6 promote formation of excitatory synapses via GluA1 AMPA receptors.

GPC4 GPC6

1.37e-05375222722203
Pubmed

Parallel visualization of multiple protein complexes in individual cells in tumor tissue.

ERBB3 EGFR

1.37e-05375223436906
Pubmed

Expression of the BRK tyrosine kinase in mammary epithelial cells enhances the coupling of EGF signalling to PI 3-kinase and Akt, via erbB3 phosphorylation.

ERBB3 EGFR

1.37e-05375211114724
Pubmed

LACTB promotes metastasis of nasopharyngeal carcinoma via activation of ERBB3/EGFR-ERK signaling resulting in unfavorable patient survival.

ERBB3 EGFR

1.37e-05375233152401
Pubmed

Ligand-induced structural transitions in ErbB receptor extracellular domains.

ERBB3 EGFR

1.37e-05375217697999
Pubmed

Neu differentiation factor/neuregulin isoforms activate distinct receptor combinations.

ERBB3 EGFR

1.37e-0537528702572
Pubmed

Type 1 receptor tyrosine kinase profiles identify patients with enhanced benefit from anthracyclines in the BR9601 adjuvant breast cancer chemotherapy trial.

ERBB3 EGFR

1.37e-05375218768436
Pubmed

Differential erbB signaling in astrocytes from the cerebral cortex and the hypothalamus of the human brain.

ERBB3 EGFR

1.37e-05375218803307
Pubmed

HER3 expression is enhanced during progression of lung adenocarcinoma without EGFR mutation from stage 0 to IA1.

ERBB3 EGFR

1.37e-05375229473311
Pubmed

Activation of nonreceptor tyrosine kinase Bmx/Etk mediated by phosphoinositide 3-kinase, epidermal growth factor receptor, and ErbB3 in prostate cancer cells.

ERBB3 EGFR

1.37e-05375217823122
Pubmed

Model-based analysis of HER activation in cells co-expressing EGFR, HER2 and HER3.

ERBB3 EGFR

1.37e-05375223990774
Pubmed

β3 integrin-EGF receptor cross-talk activates p190RhoGAP in mouse mammary gland epithelial cells.

EGFR ITGB3

1.37e-05375221937717
Pubmed

Dynamic analysis of the epidermal growth factor (EGF) receptor-ErbB2-ErbB3 protein network by luciferase fragment complementation imaging.

ERBB3 EGFR

1.37e-05375224014028
Pubmed

Neuropeptide bombesin receptor activation stimulates growth of lung cancer cells through HER3 with a MAPK-dependent mechanism.

ERBB3 EGFR

1.37e-05375231862538
Pubmed

EGF and NRG induce phosphorylation of HER3/ERBB3 by EGFR using distinct oligomeric mechanisms.

ERBB3 EGFR

1.37e-05375228320942
Pubmed

The ErbB family and androgen receptor signaling are targets of Celecoxib in prostate cancer.

ERBB3 EGFR

1.37e-05375228450158
Pubmed

EGFR, HER2, and HER3 protein expression in paired primary tumor and lymph node metastasis of colorectal cancer.

ERBB3 EGFR

1.37e-05375235902718
Pubmed

[Correlation of epidermal growth factor receptor mutations and HER2/3 protein expression with clinical outcome in advanced non-small cell lung cancer patients treated with gefitinib].

ERBB3 EGFR

1.37e-05375220038315
Pubmed

A20 negatively regulates T cell receptor signaling to NF-kappaB by cleaving Malt1 ubiquitin chains.

IKBKG TNFAIP3

1.37e-05375219494296
Pubmed

EGFR/ERBB receptors differentially modulate sebaceous lipogenesis.

ERBB3 EGFR

1.37e-05375225889637
Pubmed

The immunoexpression of EGFR, HER2 and HER3 in malignant serous ovarian tumors.

ERBB3 EGFR

1.37e-05375229556616
Pubmed

Mechanotransduction in lymphatic endothelial cells.

FBN1 ITGB3

1.37e-05375218062611
Pubmed

Structural predictions for the ligand-binding region of glycoprotein hormone receptors and the nature of hormone-receptor interactions.

FSHR TSHR

1.37e-0537528747461
Pubmed

Human CMV infection of endothelial cells induces an angiogenic response through viral binding to EGF receptor and beta1 and beta3 integrins.

EGFR ITGB3

1.37e-05375218375753
Pubmed

Expression of activated type I receptor tyrosine kinases in early breast cancer.

ERBB3 EGFR

1.37e-05375222562124
Pubmed

EGFR, HER2 and HER3 expression in primary colorectal carcinomas and corresponding metastases: Implications for targeted radionuclide therapy.

ERBB3 EGFR

1.37e-05375221109951
Pubmed

Progranulin expression in breast cancer with different intrinsic subtypes.

EGFR GRN

1.37e-05375222397762
Pubmed

HER/ErbB receptor interactions and signaling patterns in human mammary epithelial cells.

ERBB3 EGFR

1.37e-05375219878579
Pubmed

Chronic β-adrenergic stimulation increases ErbB receptors and cell proliferation in mouse kidney.

ERBB3 EGFR

1.37e-05375221554097
Pubmed

Lapatinib, a HER2 tyrosine kinase inhibitor, induces stabilization and accumulation of HER2 and potentiates trastuzumab-dependent cell cytotoxicity.

ERBB3 EGFR

1.37e-05375219060928
Pubmed

m6A‑modified HOXC10 promotes HNSCC progression via co‑activation of ADAM17/EGFR and Wnt/β‑catenin signaling.

HOXC10 EGFR

1.37e-05375238063205
Pubmed

Heregulin-induced activation of ErbB3 by EGFR tyrosine kinase activity promotes tumor growth and metastasis in melanoma cells.

ERBB3 EGFR

1.37e-05375218398842
Pubmed

The involvement of EGFR, HER2 and HER3 in the basal cell carcinomas aggressiveness.

ERBB3 EGFR

1.37e-05375230173251
Pubmed

Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice.

IKBKG TNFAIP3

1.37e-05375211009421
Pubmed

Prostatic intraepithelial neoplasia and adenocarcinoma in mice expressing a probasin-Neu oncogenic transgene.

ERBB3 EGFR

1.37e-05375216401639
Pubmed

ERBB3-independent activation of the PI3K pathway in EGFR-mutant lung adenocarcinomas.

ERBB3 EGFR

1.37e-05375225596284
Pubmed

Acquired resistance to anti-EGFR mAb ICR62 in cancer cells is accompanied by an increased EGFR expression, HER-2/HER-3 signalling and sensitivity to pan HER blockers.

ERBB3 EGFR

1.37e-05375226372697
Pubmed

Epithelial-specific ERBB3 deletion results in a genetic background-dependent increase in intestinal and colon polyps that is mediated by EGFR.

ERBB3 EGFR

1.37e-05375234843459
Pubmed

Dimerization drives EGFR endocytosis through two sets of compatible endocytic codes.

ERBB3 EGFR

1.37e-05375225588832
Pubmed

A novel kinase inhibitor, INCB28060, blocks c-MET-dependent signaling, neoplastic activities, and cross-talk with EGFR and HER-3.

ERBB3 EGFR

1.37e-05375221918175
Pubmed

DARPP-32 increases interactions between epidermal growth factor receptor and ERBB3 to promote tumor resistance to gefitinib.

ERBB3 EGFR

1.37e-05375221741919
Pubmed

Mapping ErbB receptors on breast cancer cell membranes during signal transduction.

ERBB3 EGFR

1.37e-05375217652160
Pubmed

A20/TNFAIP3 inhibits NF-κB activation induced by the Kaposi's sarcoma-associated herpesvirus vFLIP oncoprotein.

IKBKG TNFAIP3

1.37e-05375222525270
Pubmed

Progranulin (granulin/epithelin precursor) and its constituent granulin repeats repress transcription from cellular promoters.

CDK9 GRN

1.37e-05375220054825
Pubmed

Evaluation of type 1 growth factor receptor family expression in benign and malignant thyroid lesions.

ERBB3 EGFR

1.37e-05375218424286
Pubmed

Bimolecular complementation affinity purification (BiCAP) reveals dimer-specific protein interactions for ERBB2 dimers.

ERBB3 EGFR

1.37e-05375227405979
Pubmed

YAC clone contigs surrounding the Zfx and Pola loci on the mouse X chromosome.

POLA1 ZFY

1.37e-0537528406471
Pubmed

EGFR, HER2, and HER3 expression in laryngeal primary tumors and corresponding metastases.

ERBB3 EGFR

1.37e-05375218172732
InteractionDAB1 interactions

CUL5 ERBB3 EGFR LRP2 POGZ ITGB3

2.69e-06107746int:DAB1
InteractionSLC39A7 interactions

CUL5 USP49 FBN1 EGFR ESRRB GRN TRRAP

5.64e-06187747int:SLC39A7
Cytoband1p31

ACADM AK5

5.56e-04217621p31
Cytoband10p12.31

ARMC3 KIAA1217

6.11e-042276210p12.31
Cytoband11q14.3

FAT3 TRIM49C

1.30e-033276211q14.3
Cytoband22q12.3

RFPL3 RFPL2

1.38e-033376222q12.3
CytobandEnsembl 112 genes in cytogenetic band chr10p12

ENKUR ARMC3 KIAA1217

1.66e-03140763chr10p12
CytobandEnsembl 112 genes in cytogenetic band chr11q14

TRIM49 FAT3 TRIM49C

2.26e-03156763chr11q14
Cytoband17q21.32

GRN ITGB3

3.02e-034976217q21.32
CytobandEnsembl 112 genes in cytogenetic band chr14q24

ESRRB MAP3K9 LRRC74A

4.53e-03200763chr14q24
CytobandEnsembl 112 genes in cytogenetic band chr22q12

RFPL1 RFPL3 RFPL2

7.07e-03235763chr22q12
GeneFamilyGlycoprotein hormone receptors

FSHR TSHR

2.92e-053572199
GeneFamilyErb-b2 receptor tyrosine kinases

ERBB3 EGFR

5.84e-0545721096
GeneFamilyGlypicans

GPC4 GPC6

1.45e-046572572
GeneFamilyRing finger proteins

TRIM49 TRIM51 TRIM49C RFPL1 RFPL2

1.72e-0327557558
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF597 TSHZ3 ZNF423 ZKSCAN3 ZNF30 ZFY ZNF239 ZNF71

1.76e-0371857828
GeneFamilyRing finger proteins|Tripartite motif containing|ARF GTPase family

TRIM49 TRIM51 TRIM49C

3.35e-039557359
CoexpressionHAY_BONE_MARROW_STROMAL

THSD4 FBN1 HOXC10 EGFR ADAMTS9 OTOGL ZNF423 FAT3 KIAA1217 GPC4 C7

9.79e-067677411M39209
CoexpressionAtlasdev gonad_e13.5_M_InterstitFLeydig_MafB_top-relative-expression-ranked_1000

PAPPA2 FLNC FBN1 EGFR ADAMTS9 POLA1 ZNF423 FAT3 KIAA1217 GPC4 C7 ALDH3B2 GPC6 PROS1

1.86e-077737014gudmap_dev gonad_e13.5_M_InterstitFLeydig_MafB_1000
CoexpressionAtlasthyroid gland

ISM1 LRP2 TSHR PRAG1 ITGB3 FBN3 SORCS1

1.41e-05240707thyroid gland
CoexpressionAtlaskidney_P0_JuxtaGlom_Ren1_top-relative-expression-ranked_1000

THSD4 PAPPA2 FBN1 HOXC10 ACADM EGFR ADAMTS9 FAT3 GPC4 LRP2 GPC6 ITGB3

3.63e-059057012gudmap_kidney_P0_JuxtaGlom_Ren1_1000
CoexpressionAtlasdev gonad_e12.5_M_InterstitLeydig_MafB_top-relative-expression-ranked_1000

PAPPA2 FLNC FBN1 EGFR ADAMTS9 POLA1 FAT3 KIAA1217 GPC4 C7 GPC6

3.98e-057687011gudmap_dev gonad_e12.5_M_InterstitLeydig_MafB_1000
CoexpressionAtlasdev gonad_e13.5_M_InterstitFLeydig_MafB_k-means-cluster#3_top-relative-expression-ranked_1000

PAPPA2 FLNC FBN1 EGFR ZNF423 FAT3 GPC6

1.19e-04336707gudmap_dev gonad_e13.5_M_InterstitFLeydig_MafB_k3_1000
CoexpressionAtlasdev gonad_e13.5_M_InterstitTestis_Sma_top-relative-expression-ranked_200

FLNC FBN1 EGFR FAT3 KIAA1217

1.25e-04147705gudmap_dev gonad_e13.5_M_InterstitTestis_Sma_200
CoexpressionAtlasdev gonad_e13.5_M_InterstitFLeydig_MafB_top-relative-expression-ranked_500

FLNC FBN1 EGFR ADAMTS9 FAT3 KIAA1217 C7

1.70e-04356707gudmap_dev gonad_e13.5_M_InterstitFLeydig_MafB_500
CoexpressionAtlasdev gonad_e12.5_M_InterstitLeydig_MafB_top-relative-expression-ranked_500

PAPPA2 FLNC FBN1 EGFR ADAMTS9 FAT3 KIAA1217

1.95e-04364707gudmap_dev gonad_e12.5_M_InterstitLeydig_MafB_500
CoexpressionAtlasDevelopingKidney_e15.5_Peripheral blastema_emap-27731_k-means-cluster#1_top-relative-expression-ranked_500

CUL5 HOXC10 POLA1 GPC6

2.14e-0489704gudmap_developingKidney_e15.5_Peripheral blastema_500_k1
CoexpressionAtlaskidney_P4_CapMesRenVes_Crym_top-relative-expression-ranked_1000

THSD4 PAPPA2 FBN1 HOXC10 ADAMTS9 FAT3 KIAA1217 ISM1 LRP2 GPC6

2.35e-047837010gudmap_kidney_P4_CapMesRenVes_Crym_1000
CoexpressionAtlasdev gonad_e12.5_M_InterstitTestis_Sma_top-relative-expression-ranked_1000

FLNC FBN1 EGFR ADAMTS9 ZNF423 FAT3 KIAA1217 GPC4 C7 ZRANB3

2.60e-047937010gudmap_dev gonad_e12.5_M_InterstitTestis_Sma_1000
CoexpressionAtlasAravindRamakr_EmbryoidBody-LF_top-relative-expression-ranked_2500_k-means-cluster#2

PAPPA2 ENKUR FBN1 HOXC10 ARMC3 FSHR ISM1 LRP2 MINAR1 GPC6 FBN3

2.64e-049517011Arv_EB-LF_2500_K2
CoexpressionAtlaskidney_P4_CapMesRenVes_Crym_top-relative-expression-ranked_500

THSD4 PAPPA2 HOXC10 ADAMTS9 KIAA1217 ISM1 LRP2

3.35e-04398707gudmap_kidney_P4_CapMesRenVes_Crym_500
CoexpressionAtlasDevelopingKidney_e15.5_Peripheral blastema_emap-27731_top-relative-expression-ranked_1000

ZNF597 CUL5 PDS5B HOXC10 EGFR POLA1 AK5 KIAA1217 GPC6 SORCS1

3.36e-048197010gudmap_developingKidney_e15.5_Peripheral blastema_1000
CoexpressionAtlasratio_EmbryoidBody_vs_StemCell_top-relative-expression-ranked_1000

PAPPA2 FLNC ENKUR FBN1 HOXC10 ARMC3 ADAMTS9 FBXL8 ISM1 C7 ITGB3

3.84e-049947011PCBC_ratio_EB_vs_SC_1000
CoexpressionAtlaskidney_P1_CapMes_Crym_k-means-cluster#4_top-relative-expression-ranked_100

HOXC10 FAT3 ISM1

3.85e-0443703gudmap_kidney_P1_CapMes_Crym_k4_100
CoexpressionAtlaskidney_P0_JuxtaGlom_Ren1_k-means-cluster#3_top-relative-expression-ranked_1000

THSD4 PAPPA2 HOXC10 ADAMTS9 FAT3 ITGB3

4.10e-04293706gudmap_kidney_P0_JuxtaGlom_Ren1_k3_1000
CoexpressionAtlasdev gonad_e12.5_M_InterstitTestis_Sma_k-means-cluster#4_top-relative-expression-ranked_1000

FBN1 EGFR ZNF423 FAT3 C7

4.21e-04191705gudmap_dev gonad_e12.5_M_InterstitTestis_Sma_k4_1000
CoexpressionAtlasdev gonad_e11.5_M_GonadVasMes_Flk_top-relative-expression-ranked_500

PAPPA2 FLNC FBN1 POLA1 FAT3 KIAA1217 GPC6

4.49e-04418707gudmap_dev gonad_e11.5_M_GonadVasMes_Flk_500
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L5_PT-L5_PT_ALM_Hpgd|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PAPPA2 SFTPC GPC4 TEKT4 C7 SORCS1

7.97e-081267669b04ca8a46cc30119baf6ef27711a0b2a6b4a0c9
ToppCellPND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TSHZ3 FBN1 EGFR GPC6 ZRANB3 WDR62

3.16e-071597667ed659163f45e0c4df4782997c0786900c8186c8
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PIK3AP1 EGFR ADAMTS9 GPC4 LRP2 PRAG1

3.79e-07164766382e42701779d12a7948690b3be72d06dd75c8b4
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PIK3AP1 ARMC3 EGFR FAT3 GPC4 LRP2

6.75e-071817666956ecd6264f7469a25e555673bce4eb97d28f7a
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

TSHZ3 EGFR ZNF423 FAT3 C7 PRAG1

1.04e-061957660e55fa5b3cbeb7baee3d4ac272a3bf80381ec937
ToppCellfacs-Thymus-Thymus_Epithelium|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN1 EGFR GPC4 LRP2 C7 GPC6

1.07e-061967666bc1187dfc4860a4e09032d7ea87ba3d9fe9f363
ToppCellfacs-Thymus-Thymus_Epithelium-18m|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN1 EGFR GPC4 LRP2 C7 GPC6

1.07e-06196766c8c89e469402e11aa2a9561e859b6fd1fb66c39b
ToppCellPND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PAPPA2 FBN1 ISM1 GPC4 PRAG1 PROS1

1.11e-0619776626475b9e4d6bfc0ae818dea13d139888ed7e92f1
ToppCellPND14-Mesenchymal-Mesenchymal_myocytic|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

THSD4 FBN1 ISM1 GPC4 GPC6 PRAG1

1.11e-061977668c728cd3c0382c4f3e4b78647b6e1447bb40ace1
ToppCellPND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PAPPA2 FBN1 ISM1 GPC4 PRAG1 PROS1

1.11e-06197766155e63b33302a87393ace699b2f6d73abe9c5763
ToppCellPND14-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PAPPA2 FBN1 ISM1 GPC4 PRAG1 PROS1

1.14e-06198766b2d295e330772bd8e24da356c75564b4297ea9c5
ToppCellPND14-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PAPPA2 FBN1 ISM1 GPC4 PRAG1 PROS1

1.14e-06198766ce59ee3d970397eb62d6387699c6c6cd65457898
ToppCellPND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PAPPA2 FBN1 ISM1 GPC4 PRAG1 PROS1

1.14e-06198766a4005a49cf6709b543994ceb51ecd5dc46197fa9
ToppCellPND03-Mesenchymal-Mesenchymal_myocytic|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

THSD4 PAPPA2 FBN1 ISM1 GPC4 GPC6

1.14e-06198766b258f672529fb2c03e62e2696d335043c4963280
ToppCellPND10-Mesenchymal-Mesenchymal_myocytic|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PAPPA2 FBN1 ISM1 GPC4 GPC6 PRAG1

1.14e-06198766a699b365d3b6149f13f02b2e2ae9b6fdce761848
ToppCellPND14-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PAPPA2 FBN1 ISM1 GPC4 PRAG1 PROS1

1.14e-061987663ffaea4b44067d69f954b2bd3119c88a55ab232a
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW13-Mesenchymal-Mesoderm|GW13 / Sample Type, Dataset, Time_group, and Cell type.

TSHZ3 ENKUR GPR156 MINAR1 ZRANB3 ZNF71

1.21e-062007660f4b8b0868bda406fe6bf01d1b722510fdfd0168
ToppCellLPS-antiTNF-Myeloid-Monocytes,_Macrophages-Erythroid|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SFTPC KIAA1217 LRP2 GPR156 C7

4.82e-061447651b9e95e4f6e40042d3cf2f94c067f3a6b19428ea
ToppCellTCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Adenocarcinoma_Mixed_Subtype-4|TCGA-Lung / Sample_Type by Project: Shred V9

FBN1 ISM1 GPC6 ITGB3 MILR1

1.28e-051767650923b01137d6f9956ca815b41102c81e82624065
ToppCell10x3'2.3-week_12-13-Mesenchymal_myocytic-stroma-muscle_stem_cell|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

HOXC10 ADAMTS9 FAT3 ISM1 GPC4

1.35e-051787658f31b3fac51591f7f2bcb898c07708b3e9f93a16
ToppCellE18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FBN1 GPC4 GPC6 ITGB3 ZRANB3

1.39e-05179765ce3ca7f3a5864e62307aa744a3173f350a90df28
ToppCellLA-01._Fibroblast_I|LA / Chamber and Cluster_Paper

FBN1 EGFR C7 GPC6 SORCS1

1.39e-05179765dcb6ec9ae72b13fe388b72dace2815293fafe8ee
ToppCell5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FBN1 SCUBE2 C7 GPC6 SORCS1

1.50e-051827653dfa9187e9d2bab1d199079d29209c4648220ada
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

THSD4 FAT3 ISM1 GPC6 SORCS1

1.54e-051837657eae9b3b4d1c9b135fa7cff348393d4adec474b4
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

OTOGL FAT3 LRP2 SSPOP SORCS1

1.58e-051847652cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

OTOGL FAT3 LRP2 SSPOP SORCS1

1.58e-05184765ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

OTOGL FAT3 LRP2 SSPOP SORCS1

1.58e-051847652b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PIK3AP1 ARMC3 EGFR ADAMTS9 GPC4

1.67e-051867655c4ffe4e4d5536ae9f8794277fe032c693e7dd56
ToppCellCOVID-19-Epithelial_cells|COVID-19 / group, cell type (main and fine annotations)

THSD4 ERBB3 EGFR SFTPC KIAA1217

1.75e-05188765c9cdee6f8d42ee69f5fb335f25084603c511bd29
ToppCell10x3'2.3-week_14-16-Mesenchymal_myocytic-stroma-muscle_stem_cell|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

FAT3 ISM1 GPC4 C7 GPC6

1.75e-05188765de6f4889e0c5f39fbbaefd85526f645c6afa09d5
ToppCellfacs-Lung-nan-3m-Mesenchymal-pulmonary_interstitial_fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PAPPA2 ISM1 GPC4 PRAG1 SORCS1

1.85e-05190765c7bd087f36321cec61b98657433b4d19d135791f
ToppCellfacs-Lung-nan-3m-Mesenchymal-Myofibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PAPPA2 ISM1 GPC4 PRAG1 SORCS1

1.85e-05190765834218fcc59df5e7e52de154272f3d55d81d0dac
ToppCell10x3'2.3-week_12-13-Mesenchymal_osteo-stroma-osteoblast_precursor|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

HOXC10 ADAMTS9 FAT3 GPC4 GPC6

1.89e-0519176598b907f8fa024cf32e462323b782c5a371327bbd
ToppCellfacs-Lung-3m-Mesenchymal-fibroblast|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FBN1 SCUBE2 EGFR ISM1 C7

1.89e-05191765997abf0cc5873bed0372c4a333ed307fa72774d2
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

THSD4 TSHZ3 FBN1 KIAA1217 C7

1.94e-051927659093a9e94a25682d109a7f6edc256a25a61103a0
ToppCellfacs-Lung-nan-3m-Mesenchymal-Adventitial_Fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN1 EGFR ISM1 C7 GPC6

1.94e-05192765a2c31390da4962bda9a936470b0b68fa1f5d47d1
ToppCellPND14-Mesenchymal-Mesenchymal_structural|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FBN1 SCUBE2 FAT3 ISM1 C7

1.94e-0519276525492568f9cbe097b7bb1db50d8b817c80ea87d7
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

THSD4 TSHZ3 FBN1 KIAA1217 C7

1.94e-051927659ed5d49621ec1aa01716dc369bba1450b5f015f5
ToppCellfacs-Lung-nan-3m-Mesenchymal-adventitial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN1 EGFR ISM1 C7 GPC6

1.94e-05192765eeab1cef7c36ae824381952c5b2c982368c379fd
ToppCellCOVID-19-Heart-Fib_+_EC_+_Pericyte|Heart / Disease (COVID-19 only), tissue and cell type

TSHZ3 FBN1 EGFR C7 GPC6

1.94e-0519276560b1312e84f6d6448365a952469c506c00b5fe93
ToppCellPND14-Mesenchymal-Mesenchymal_structural-Fibroblastic|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FBN1 SCUBE2 FAT3 ISM1 C7

1.94e-05192765de9c1536d5aee86f9c62acbc54ca8fa581c00f17
ToppCelldroplet-Lung-30m-Mesenchymal-fibroblast-alveolar_fibroblast-alveolar_fibroblast_l49|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FBN1 SCUBE2 FAT3 ISM1 C7

1.94e-05192765ff4b728a55c2550c806c47e9ae3d057c35df8464
ToppCelldroplet-Lung-30m-Mesenchymal-fibroblast-alveolar_fibroblast|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FBN1 SCUBE2 FAT3 ISM1 C7

1.94e-051927652d3790bd80a7f214b37094121a2a86ff16362569
ToppCellAdult-Mesenchymal-matrix_fibroblast_2_cell|Adult / Lineage, Cell type, age group and donor

FBN1 ZNF423 ISM1 C7 GPC6

1.94e-05192765d21f0f577156f17c899b08871046a26b88aea011
ToppCellPND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FBN1 SCUBE2 FAT3 ISM1 C7

1.99e-051937654c74a3f69b2cbdf139e7e66b44bd86869ac34dc0
ToppCellPND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FBN1 SCUBE2 FAT3 ISM1 C7

1.99e-05193765ff8ceeb3cfd1bef7239df490c19d181091750833
ToppCellfacs-Lung-nan-3m-Mesenchymal|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN1 EGFR ISM1 C7 GPC6

1.99e-05193765d9c20a092b507c43fcf7ccb04073fecd27d1749c
ToppCellMesenchymal-matrix_fibroblast_1_cell|World / Lineage, Cell type, age group and donor

TSHZ3 FBN1 FAT3 C7 GPC6

1.99e-05193765acad568621ed677031797b8c2e34dafea798d681
ToppCell10x3'2.3-week_17-19-Mesenchymal_myocytic-stroma-myofibroblast|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

THSD4 FLNC HOXC10 EGFR FBN3

1.99e-0519376502dfd1df1e7fc84bfca2b0c95138b5b4408bb5d1
ToppCelldroplet-Lung-18m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l1|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FLNC FBN1 EGFR ISM1 GPC6

2.04e-051947655594f7437448cb4b37d2d100f44d30c4a367df26
ToppCellFetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

TSHZ3 FBN1 FAT3 C7 GPC6

2.04e-05194765011e14d9ed1393275f892060e7708ffadcd0767f
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

TSHZ3 EGFR ZNF423 FAT3 C7

2.04e-05194765b1bb0f846d2865efdd9bc8842b16b9d069785882
ToppCellLA-02._Fibroblast_II|LA / Chamber and Cluster_Paper

FBN1 EGFR C7 GPC6 SORCS1

2.04e-05194765234d1494c114cce77c619708bbcd8d5ce805f19b
ToppCelldroplet-Bladder-Unstain-18m-Epithelial-bladder_mesenchymal_cell_(Car3+)|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THSD4 ADAMTS9 ISM1 TNFAIP3 GPC6

2.09e-05195765841fde528ecb293e07b5e00e499d1e9f0b0dce14
ToppCellPND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PAPPA2 FBN1 GPC4 PRAG1 PROS1

2.09e-051957652514c1f23424b5fc664d326d31ffd22bafe74ef8
ToppCell10x3'2.3-week_17-19-Mesenchymal_osteo-stroma-osteoblast_precursor|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

HOXC10 EGFR ADAMTS9 FAT3 GPC4

2.09e-05195765ec12cfb2fce44cc2de4e198ef5af075e626f0329
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

THSD4 TSHZ3 FBN1 KIAA1217 C7

2.09e-05195765803f714d91f2d97ecbee8c15a5139fd9310f66c7
ToppCellPND14-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FBN1 SCUBE2 FAT3 ISM1 C7

2.09e-051957653a0cad69cfc150a27a0666f612f5294c817197d7
ToppCellIPF-Stromal-Fibroblast|World / Disease state, Lineage and Cell class

FLNC FBN1 EGFR C7 GPC6

2.09e-051957659c32756edb54f0c211185d9a98073fe01fd1526a
ToppCellPND14-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FBN1 SCUBE2 FAT3 ISM1 C7

2.09e-051957652b8ee7990267bb52b7e6ae03f509ffebf8908122
ToppCellfacs-Lung-3m-Mesenchymal-myofibroblast-myofibroblast_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PAPPA2 ISM1 GPC4 PRAG1 SORCS1

2.09e-05195765c6bb16c0076639c6ddef1a15d8cba44bc29c077d
ToppCellfacs-Lung-3m-Mesenchymal-myofibroblast-myofibroblast_cell-pulmonary_interstitial_myofibroblast|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PAPPA2 ISM1 GPC4 PRAG1 SORCS1

2.09e-05195765ea89f80d3d7e9f737442f7c1aa1791d277ffc90c
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

THSD4 TSHZ3 FBN1 KIAA1217 C7

2.09e-051957654f70157d42a16ff0259bc24a62803c4df4285c44
ToppCellPND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PAPPA2 FBN1 GPC4 PRAG1 PROS1

2.14e-05196765e4d04e1f82779e8afd4e32bbe38d1d3f6f64ab50
ToppCellPND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PAPPA2 FBN1 GPC4 PRAG1 PROS1

2.14e-05196765f0fd7db22985d2bc84dc8bcbdb2d552e280121dd
ToppCellfacs-Lung-nan|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN1 EGFR ISM1 GPC6 PROS1

2.14e-05196765b05f77f3990b662682ffeaf0e4c2fb190e0a6e65
ToppCellfacs-Lung-nan-3m|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN1 EGFR ISM1 GPC6 PROS1

2.14e-05196765787c6cd92035e0b1108c2c086c42a229016e476b
ToppCellPCW_13-14-Mesenchymal|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

TSHZ3 FBN1 FAT3 C7 GPC6

2.20e-0519776573a2085d2682d636726a5432d572ae2a3fbe1c3f
ToppCell10x5'v1-week_12-13-Mesenchymal_osteo-stroma-osteoblast_precursor|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

HOXC10 ADAMTS9 FAT3 GPC4 GPC6

2.20e-051977652f72fd9a5b6d62c24a95ed2246194ea7458c0f12
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

THSD4 TSHZ3 FBN1 KIAA1217 C7

2.20e-05197765b349f8e96d61a4c296af64711e11fc44459a9413
ToppCellPND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PAPPA2 FBN1 ISM1 GPC4 PROS1

2.20e-051977659d7a1c7dc70ba5e35645f19f9e056e4fa2494aa0
ToppCellPND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PAPPA2 FBN1 ISM1 GPC4 PROS1

2.20e-05197765090a251194da3e2806989d9a522588f83f52da7f
ToppCellPND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PAPPA2 FBN1 ISM1 GPC4 PROS1

2.20e-0519776543b5f8e917506c1717f9311584901b506ffd2c79
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

THSD4 TSHZ3 FBN1 KIAA1217 C7

2.20e-05197765c2e390653d5dee7e731c1840cfdab41987dede9b
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ERBB3 GPC4 LRP2 GPC6 PROS1

2.25e-05198765be305d89d48c67ce922fa71aaf15e24d00c89ff6
ToppCell10x5'v1-week_14-16-Mesenchymal_osteo-stroma-osteoblast_precursor|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

ADAMTS9 FAT3 ISM1 GPC4 GPC6

2.25e-05198765bc9c9f2c87282b5ef8514773e065d2a6b5dde338
ToppCellFetal_29-31_weeks-Mesenchymal|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

TSHZ3 FBN1 FAT3 C7 GPC6

2.25e-0519876521cf4d81386761d09d0f6829c01c198e5524176d
ToppCellPCW_10-12-Mesenchymal|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

TSHZ3 FBN1 FAT3 C7 GPC6

2.30e-05199765a09292de4c4447b8eee55d401808e43b817321cc
ToppCell5'-GW_trimst-1.5-SmallIntestine-Mesenchymal-immature_mesenchymal_cell|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

THSD4 TSHZ3 FBN1 GPC4 GPC6

2.30e-051997653cf62666ffd000427fdbb7cf940793f98c3ed29c
ToppCellfacs-Trachea-nan-3m-Mesenchymal|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN1 ISM1 GPC4 GPC6 PROS1

2.30e-0519976567f78c070c56e44fba36542041bf7fa1c291807c
ToppCellfacs-Trachea-nan-3m-Mesenchymal-nan|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN1 ISM1 GPC4 GPC6 PROS1

2.30e-051997651ae244b563f85c1ee8d22698f478c842a4d9c7f5
ToppCellBronchus_Control_(B.)-Stromal-TX-Fibroblasts-2,_SCARA5|Bronchus_Control_(B.) / Sample group, Lineage and Cell type

FBN1 ZNF423 ISM1 C7 GPC6

2.36e-052007652022df85df94ab8cbb4e80e3fe9894c01051c5e0
ToppCellBronchus_Control_(B.)-Stromal-TX|Bronchus_Control_(B.) / Sample group, Lineage and Cell type

FBN1 ZNF423 ISM1 C7 GPC6

2.36e-0520076569b41f5fb370aa8840a9ad7919d03ef1e57d1b5b
ToppCellLPS_IL1RA_TNF-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

THSD4 FBN1 GPC4 MINAR1 SORCS1

2.36e-0520076509537dc25f8b8b4654a7c183827ee1522a41a4e0
ToppCell3'-GW_trimst-1-SmallIntestine-Mesenchymal-immature_mesenchymal_cell|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

THSD4 TSHZ3 FBN1 GPC4 GPC6

2.36e-052007653dacd0afe69bc16bb33336ea9ea99a9cd47731d9
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L5_PT|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PAPPA2 SFTPC GPC4 C7

8.17e-05134764cb676d5bbc468bd3ce1b6712d41c986ee9221ac5
ToppCellfrontal_cortex|World / Per Region, Lineage, Cell class, Cell type, Cell subtype

PAPPA2 FAT3 ALDH3B2 GPC6

1.33e-04152764f9c29d4568402ca07a717dbffb3ccc7f35c5fe56
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4/8-lo-Tgd_CRTAM|GI_small-bowel / Manually curated celltypes from each tissue

PIK3AP1 ENKUR LRP2 RFPL2

1.43e-041557641c67f58ed79331addbc012dab0cb09a7f350aedb
ToppCellPND07-28-samps-Mesenchymal-Mesothelial|PND07-28-samps / Age Group, Lineage, Cell class and subclass

ELAPOR2 LRP2 TSHR ALDH3B2

1.47e-04156764574f761962a7dd3308bd41fc529dd3ea1b8625f8
ToppCellPND07-28-samps-Mesenchymal-Mesothelial-Mesothelial|PND07-28-samps / Age Group, Lineage, Cell class and subclass

ELAPOR2 LRP2 TSHR ALDH3B2

1.47e-04156764605d95a900e1443d3f6aae163ef2e893d3293203
ToppCellwk_15-18-Mesenchymal-Myofibro_&_SMC-Myofibro_2|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

THSD4 FAT3 ISM1 PRAG1

1.51e-04157764b9d04ee417c0d8ea0801d10f1c54e138587009fd
ToppCellChildren_(3_yrs)-Mesenchymal-chondrocyte-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

FBN1 SFTPC FAT3 C7

1.54e-04158764e5636c0b608d68bd426a2b446ac508e4512e86a4
ToppCell356C-Myeloid-Macrophage-FABP4+_Macrophage|356C / Donor, Lineage, Cell class and subclass (all cells)

THSD4 GPC6 MILR1 WDR62

1.58e-0415976424f87c666eff10c1844c900ffd7ad49fa9f80481
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAT3 FSHR LRP2 SORCS1

1.62e-04160764c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAT3 FSHR LRP2 SORCS1

1.62e-0416076425c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCellsaliva-Severe-critical_progression_d12-22_with-steroid|saliva / Compartment, severity and other cell annotations on 10x 3' data (130k)

PIK3AP1 GRN ARHGAP25 MILR1

1.66e-041617641b5ebc82ee6166ecc2984648565f334cd69b636b
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Lymphocytic-CD8-positive,_alpha-beta_T_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PIK3AP1 ARHGAP4 ARMC3 TNFAIP3

1.70e-0416276458fe827198c172eeaa26273b0fad7991a718b0bf
ToppCell356C-Myeloid-Macrophage-FABP4+_Macrophage|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

THSD4 ERBB3 GPC6 WDR62

1.70e-041627642259e9536147e9cdee772e3a30ba7d104573262c
ToppCell343B-Epithelial_cells-Epithelial-A_(AT2)-|343B / Donor, Lineage, Cell class and subclass (all cells)

ELAPOR2 SFTPC OTOGL LRP2

1.78e-04164764beaa13a75c3bb72446c85084d75e9fe3f15fd3d4
ToppCell343B-Epithelial_cells-Epithelial-A_(AT2)|343B / Donor, Lineage, Cell class and subclass (all cells)

ELAPOR2 SFTPC OTOGL LRP2

1.78e-04164764d005cfd821b87548b075120bffe65a0be9860463
ComputationalPlacenta genes.

ARHGAP4 ERBB3 EGFR SFTPC IKBKG GRN TNFAIP3 ALDH3B2

7.52e-05463348MODULE_38
Diseaseconnective tissue disease (implicated_via_orthology)

FBN1 FBN3

1.66e-053702DOID:65 (implicated_via_orthology)
Diseasescoliosis (implicated_via_orthology)

ADAMTS9 SSPOP

5.52e-055702DOID:0060249 (implicated_via_orthology)
DiseaseGastric Adenocarcinoma

ERBB3 MAP3K9 TRRAP

1.69e-0445703C0278701
Diseasemitral valve prolapse (is_implicated_in)

FBN1 TSHR

1.98e-049702DOID:988 (is_implicated_in)
DiseaseHead and Neck Carcinoma

ERBB3 EGFR

2.47e-0410702C3887461
Diseasegallbladder neoplasm

ERBB3 EGFR

3.01e-0411702C0016978
DiseaseMalignant neoplasm of gallbladder

ERBB3 EGFR

3.01e-0411702C0153452
Diseaseserum dimethylarginine measurement

THSD4 ARHGAP25 GPC6

4.58e-0463703EFO_0005418
Diseasemembranous glomerulonephritis (biomarker_via_orthology)

LRP2 C7

4.96e-0414702DOID:10976 (biomarker_via_orthology)
Diseasemedian neuropathy (biomarker_via_orthology)

ERBB3 EGFR

4.96e-0414702DOID:571 (biomarker_via_orthology)
Diseasebacterial pneumonia (biomarker_via_orthology)

SFTPC ITGB3

4.96e-0414702DOID:874 (biomarker_via_orthology)
DiseaseCraniofacial Abnormalities

EGFR GPC4 LRP2 GPC6

5.25e-04156704C0376634
Diseasecutaneous psoriasis measurement, psoriasis

USP49 TNFAIP3

6.52e-0416702EFO_0000676, EFO_0007773
Diseaseautoimmune disease

ERBB3 TSHR TNFAIP3 ITGB3

7.74e-04173704EFO_0005140
Diseaseattempted suicide

ELAPOR2 FBN1 SCUBE2 LRP2

8.61e-04178704EFO_0004321
Diseasedilated cardiomyopathy (implicated_via_orthology)

FLNC EGFR ESRRB

9.22e-0480703DOID:12930 (implicated_via_orthology)
Diseaselaryngeal squamous cell carcinoma (is_marker_for)

ERBB3 EGFR

9.24e-0419702DOID:2876 (is_marker_for)
Diseaseresponse to methotrexate, neurotoxicity

PNPLA6 GPC6

9.24e-0419702EFO_0011057, GO_0031427
Diseaseglomerulonephritis (biomarker_via_orthology)

FBN1 ITGB3

1.03e-0320702DOID:2921 (biomarker_via_orthology)
Diseasecortical thickness

THSD4 PDS5B ERBB3 FBN1 EGFR ADAMTS9 ZNF423 FAT3 FSHR

1.23e-031113709EFO_0004840
Diseasestomach carcinoma (is_marker_for)

ERBB3 TNFAIP3

1.48e-0324702DOID:5517 (is_marker_for)
Diseasemaximal oxygen uptake measurement

ESRRB TSHR

1.74e-0326702EFO_0004887
Diseasechronic obstructive pulmonary disease (biomarker_via_orthology)

ERBB3 EGFR

2.02e-0328702DOID:3083 (biomarker_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
VDQTSCVRACPPDKM

ERBB3

296

P21860
ESKCPELLANYCDML

CUL5

401

Q93034
DVKCDMEVSCPDGYT

GRN

281

P28799
SPDPDVKKNSMECIY

ARMC3

161

Q5W041
EEPLMCAYCVTEPGA

ACADM

151

P11310
QTCVAPDYVLCSPEM

ALDH3B2

161

P48448
TTCLDMDECSQVPKP

FBN3

2401

Q75N90
MKCSLNPGCDEDLYE

PIK3AP1

431

Q6ZUJ8
YCMAKEDVPNDRCSA

C17orf113

136

A0A1B0GUU1
PLEYMAICALCAKDP

PDS5B

936

Q9NTI5
CEYLRPPIDCFKTMD

PNPLA6

1221

Q8IY17
LMCSKPEDPVEYLES

AK5

26

Q9Y6K8
PQGSTCCSQEMEEKY

GPC4

61

O75487
MEDGTCKVTYCPTEP

FLNC

2091

Q14315
SDKMLYCEAESPPTV

LRRC74A

41

Q0VAA2
CCPKCQYQAPDMDTL

IKBKG

396

Q9Y6K9
CGDMSDEKDCPTQPF

LRP2

1296

P98164
YCADPPLIKMACAGT

OR5M3

176

Q8NGP4
CPACMKATLQPEYSD

POLA1

1371

P09884
YIEKETNQCKECPPD

ELAPOR2

626

A8MWY0
CEAMKTNEFPSPCLD

MILR1

26

Q7Z6M3
RESCNDPCKETVPSM

PAPPA2

751

Q9BXP8
DEATCKDTCPPLMLY

EGFR

256

P00533
DYIPETDQDCSMSPC

ADAMTS9

1281

Q9P2N4
PQEYTCCTTEMEDKL

GPC6

61

Q9Y625
SCECELEGMLPPYLS

FBXL8

51

Q96CD0
MCPAVNTSEYKILCP

FBN1

1576

P35555
KMPYECGPSLDVCAQ

C7

716

P10643
EKPCPGDMQCVSYEA

FAT3

3801

Q8TDW7
MDPTCSSECIYNLIP

ENKUR

1

Q8TC29
YPPSVKEENVCCMYS

HOXC10

101

Q9NYD6
PEALENPCYDMKTTC

ITGB3

196

P05106
EPDDNSLQSPEMKCY

FOXR2

161

Q6PJQ5
MEPEINCSELCDSFP

GPR156

1

Q8NFN8
PCRKSYEDCASGIME

ESRRB

71

O95718
CSPKPDAFNPCEDIM

FSHR

346

P23945
MAKQYDSVECPFCDE

CDK9

1

P50750
TADGPECSCHPQYKM

SCUBE2

231

Q9NQ36
MNDLPSCPCSYPTEV

ISM1

316

B1AKI9
PSTCPEPFAKLMEDC

MAP3K9

371

P80192
LECEPQKFDPVYDCS

OTOGL

1471

Q3ZCN5
APGTCCYIMKIAPES

SFTPC

116

P11686
MDCKDCPQFVPASEP

MINAR1

161

Q9UPX6
EASSCPVCSDYLEKP

RFPL1

36

O75677
PVCSDYLEKPMSLEC

RFPL1

41

O75677
PLCMNYFIDPVTIDC

TRIM49

16

P0CI25
MPEEPYLQSQCDCCS

SSPOP

5091

A2VEC9
ELAEDCKRPLPCMTY

FER1L5

626

A0AVI2
LPCFEESDCKESSPM

NANOGP8

11

Q6NSW7
DTHKPGEMPYVCQVC

POGZ

581

Q7Z3K3
PKNCSVELTPDYSME

SGSM3

451

Q96HU1
MEENESQKCEPCLPY

KIAA1217

1

Q5T5P2
MAQTVPPCELPCKEY

TEKT4

1

Q8WW24
CSPLPCNEDGYMSCK

PROS1

121

P07225
YEKCMAPPSASCLGD

ARHGAP4

706

P98171
CKEMPTSENCPSFAL

ZNF30

96

P17039
SLMDVKCETPNCPFF

TNFAIP3

381

P21580
PICMNYFLDPVTIDC

TRIM51

16

Q9BSJ1
EEDTKPQGCMYLPGC

ARHGAP25

81

P42331
PLCMNYFIDPVTIDC

TRIM49C

16

P0CI26
PYCCRDMLSSLDKET

USP49

581

Q70CQ1
CPVCSDYLEKPMSLE

RFPL2

101

O75678
DYLEKPMSLECGCAV

RFPL2

106

O75678
EASSCPVCSDYLEKP

RFPL3

36

O75679
PVCSDYLEKPMSLEC

RFPL3

41

O75679
LESDYCSLMKEPAPE

PRAG1

361

Q86YV5
MCPEKELARACPSYQ

TSHZ3

46

Q63HK5
DLDCYFTPMKPESLE

WDR62

881

O43379
LENVETPMSYKCNEC

ZKSCAN3

471

Q9BRR0
SKFKPLQCPDCDMTF

ZNF597

336

Q96LX8
PMCPEQFSSVEGVYC

ZNF423

326

Q2M1K9
EKPYECEECGMSFSQ

ZNF239

316

Q16600
EEAPESYCDSSMKPT

THSD4

651

Q6ZMP0
KYAGAMESEPCVCTE

SORCS1

711

Q8WY21
PMPCEEKKTYDCSEC

ZNF71

121

Q9NQZ8
PLSPFCQFEEMKICS

TRRAP

1501

Q9Y4A5
ESEMDPCKVDSTCPE

ZFY

231

P08048
SELPYCEMCETPQGS

ZRANB3

636

Q5FWF4
MVCTPKSDEFNPCED

TSHR

396

P16473