Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	APC_su10/DOC_dom	MYCBP2 CUL9 HERC2	1.75e-06	7	70	3	IPR004939
Domain	DOC	MYCBP2 CUL9 HERC2	1.75e-06	7	70	3	PS51284
Domain	APC10	MYCBP2 CUL9 HERC2	1.75e-06	7	70	3	SM01337
Domain	ANAPC10	MYCBP2 CUL9 HERC2	1.75e-06	7	70	3	PF03256
Domain	WWE	DDHD2 HUWE1 PARP14	1.08e-05	12	70	3	PS50918
Domain	WWE	DDHD2 HUWE1 PARP14	1.08e-05	12	70	3	PF02825
Domain	WWE-dom	DDHD2 HUWE1 PARP14	1.08e-05	12	70	3	IPR004170
Domain	Cul7	CUL9 HERC2	4.14e-05	3	70	2	PF11515
Domain	PUA	NSUN6 DKC1	4.14e-05	3	70	2	PF01472
Domain	CPH_domain	CUL9 HERC2	4.14e-05	3	70	2	IPR021097
Domain	RCC1	MYCBP2 HERC2 HERC5	5.49e-05	20	70	3	PF00415
Domain	RCC1_1	MYCBP2 HERC2 HERC5	6.39e-05	21	70	3	PS00625
Domain	RCC1_2	MYCBP2 HERC2 HERC5	6.39e-05	21	70	3	PS00626
Domain	RCC1_3	MYCBP2 HERC2 HERC5	6.39e-05	21	70	3	PS50012
Domain	Reg_chr_condens	MYCBP2 HERC2 HERC5	7.38e-05	22	70	3	IPR000408
Domain	-	MYCBP2 HERC2 HERC5	7.38e-05	22	70	3	2.130.10.30
Domain	RCC1/BLIP-II	MYCBP2 HERC2 HERC5	8.46e-05	23	70	3	IPR009091
Domain	-	NSUN6 DKC1	1.37e-04	5	70	2	2.30.130.10
Domain	PUA	NSUN6 DKC1	1.37e-04	5	70	2	PS50890
Domain	PUA	NSUN6 DKC1	1.37e-04	5	70	2	IPR002478
Domain	HECT	HUWE1 HERC2 HERC5	1.38e-04	27	70	3	PF00632
Domain	HECTc	HUWE1 HERC2 HERC5	1.38e-04	27	70	3	SM00119
Domain	HECT_dom	HUWE1 HERC2 HERC5	1.38e-04	27	70	3	IPR000569
Domain	HECT	HUWE1 HERC2 HERC5	1.38e-04	27	70	3	PS50237
Domain	-	MYCBP2 CUL9 HERC2 EPHA10	1.62e-04	73	70	4	2.60.120.260
Domain	Ribosomal_S5_D2-typ_fold	EEF2 EXOSC6 TOP2B	2.78e-04	34	70	3	IPR020568
Domain	Galactose-bd-like	MYCBP2 CUL9 HERC2 EPHA10	4.28e-04	94	70	4	IPR008979
Domain	MFS	SLC18A1 SLC22A2 SLC49A4 SLC2A11	7.23e-04	108	70	4	PS50850
Domain	MFS_dom	SLC18A1 SLC22A2 SLC49A4 SLC2A11	1.61e-03	134	70	4	IPR020846
Domain	SUGAR_TRANSPORT_2	SLC22A2 SLC2A11	1.82e-03	17	70	2	PS00217
Domain	Rib_L2_dom2	CUL9 HERC2	2.04e-03	18	70	2	IPR014722
Domain	-	CUL9 HERC2	2.04e-03	18	70	2	2.30.30.30
Domain	PUA-like_domain	NSUN6 DKC1	2.27e-03	19	70	2	IPR015947
Domain	-	EEF2 TOP2B	2.78e-03	21	70	2	3.30.230.10
Domain	Ribosomal_S5_D2-typ_fold_subgr	EEF2 TOP2B	3.05e-03	22	70	2	IPR014721
Domain	SUGAR_TRANSPORT_1	SLC22A2 SLC2A11	3.62e-03	24	70	2	PS00216
Domain	Sugar_transporter_CS	SLC22A2 SLC2A11	6.39e-03	32	70	2	IPR005829
Pathway	REACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT	RHBG SLC18A1 SLC22A2 SLC13A5 SLC34A3 SLC1A5 SLC2A11	5.47e-05	249	56	7	M5988
Pubmed	Autoregulation of the 26S proteasome by in situ ubiquitination.	ADRM1 PSMC3 HUWE1 HERC2	6.76e-08	19	73	4	24743594
Pubmed	Multi-omics profiling identifies a deregulated FUS-MAP1B axis in ALS/FTD-associated UBQLN2 mutants.	DNAJB12 EEF2 EPPK1 PSMC3 HUWE1 CPS1 HM13 SLC1A5	6.87e-08	256	73	8	35777956
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	SYNRG EPPK1 MEGF8 MYCBP2 AHNAK EXOSC6 CUL9 TNFAIP2 HUWE1 HERC2 WNK1 SLC1A5 KIAA2013	4.62e-07	1105	73	13	35748872
Pubmed	Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.	MYCBP2 CUL9 HUWE1 HERC2 HERC5	1.77e-06	95	73	5	29643511
Pubmed	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	PRUNE2 SALL2 HUWE1 HERC2 WNK1	2.77e-06	104	73	5	9205841
Pubmed	Identification of proximal SUMO-dependent interactors using SUMO-ID.	SYNRG SALL2 PRPF3 AHNAK PSMC3 CPS1 SLC1A5 TOP2B	4.31e-06	444	73	8	34795231
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	ZHX3 SYNRG EME1 EEF2 BRD8 MYCBP2 DKC1 HUWE1 ADCY6 TOP2B	4.94e-06	774	73	10	15302935
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	EEF2 EPPK1 MYCBP2 AHNAK MOV10L1 PSMC3 ZFHX3 HUWE1 OGDH SLC1A5	7.11e-06	807	73	10	30575818
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	PRUNE2 ZHX3 SALL2 MYCBP2 WNK1 ADCY6	8.13e-06	225	73	6	12168954
Pubmed	Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.	PRUNE2 BRD8 ADRM1 COL27A1 EXOSC6 DKC1 CUL9 HUWE1	9.65e-06	496	73	8	31343991
Pubmed	Two olfactory receptors-OR2A4/7 and OR51B5-differentially affect epidermal proliferation and differentiation.	OR2A7 OR2A4	1.30e-05	3	73	2	27315375
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	BUD23 DNAJB12 EEF2 EPPK1 MYCBP2 ADRM1 NOMO2 AHNAK PSMC3 HM13 WNK1 SLC1A5	1.54e-05	1297	73	12	33545068
Pubmed	The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell proliferation and targets the transcription factor Hbp1 for degradation.	EPPK1 DKC1 HUWE1 WNK1 TOP2B HERC5	1.58e-05	253	73	6	29911972
Pubmed	Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways.	EEF2 EPPK1 AHNAK OGDH HERC5	1.76e-05	152	73	5	16009940
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	ZHX3 SYNRG PRPF3 AHNAK ATG2B DKC1 WNK1 SLC1A5 TOP2B HERC5	2.50e-05	934	73	10	33916271
Pubmed	A zonal organization of odorant receptor gene expression in the olfactory epithelium.	OR2A7 OR2A4	2.60e-05	4	73	2	7683976
Pubmed	E3 ligases Arf-bp1 and Pam mediate lithium-stimulated degradation of the circadian heme receptor Rev-erb alpha.	MYCBP2 HUWE1	2.60e-05	4	73	2	20534529
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	RNGTT MYCBP2 PRPF3 EXOSC6 DKC1 HERC2 OGDH TOP2B HERC5	2.99e-05	759	73	9	35915203
Pubmed	Defining the membrane proteome of NK cells.	DNAJB12 EEF2 MYCBP2 AHNAK PSMC3 HUWE1 HERC2 HM13 PARP14 SLC1A5 KIAA2013	3.09e-05	1168	73	11	19946888
Pubmed	DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization.	EEF2 MYCBP2 PSMC3 HUWE1 NXN	3.47e-05	175	73	5	25756610
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	DNAJB12 EEF2 EPPK1 PRPF3 AHNAK EXOSC6 PSMC3 DKC1 HUWE1 CPS1 WNK1 TOP2B	3.63e-05	1415	73	12	28515276
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	RNGTT MYCBP2 PRPF3 DKC1 HUWE1 HERC2 TOP2B	3.93e-05	440	73	7	34244565
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	DNAJB12 MYCBP2 NOMO2 ATG2B SRR HUWE1 HERC2 HM13	4.03e-05	606	73	8	36538041
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	MYCBP2 ADRM1 PRPF3 PSMC3 DKC1 HUWE1 HERC2 NXN OGDH SLC1A5	4.64e-05	1005	73	10	19615732
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	EPPK1 MYCBP2 PRPF3 AHNAK EXOSC6 DKC1 HUWE1 HERC2 SLC1A5 TOP2B	5.43e-05	1024	73	10	24711643
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	DNAJB12 PRUNE2 THRA MYCBP2 PRPF3 ZFHX3 ST3GAL3 HUWE1 HM13 NXN OGDH SLC2A11	5.93e-05	1489	73	12	28611215
Pubmed	C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.	DNAJB12 EEF2 RNGTT MYCBP2 ADRM1 NOMO2 PSMC3 DKC1 HUWE1 HM13 SLC1A5	6.00e-05	1257	73	11	37317656
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	DNAJB12 MYCBP2 GHITM ATG2B PSMC3 DKC1 ALDH4A1 DDHD2 HUWE1 HERC2 HM13 OGDH	6.20e-05	1496	73	12	32877691
Pubmed	∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.	DNAJB12 EEF2 EPPK1 ADRM1 AHNAK EXOSC6 PSMC3 HUWE1	6.38e-05	647	73	8	26618866
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	EPPK1 MYCBP2 AHNAK PSMC3 CUL9 HUWE1 HERC2 HERC5	6.80e-05	653	73	8	22586326
Pubmed	SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.	DNAJB12 EEF2 ADRM1 PSMC3 HUWE1 HERC2 HM13 SLC1A5	7.10e-05	657	73	8	36180527
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	EPPK1 AHNAK SLC49A4 EXOSC6 HUWE1 PARP14	7.19e-05	332	73	6	37433992
Pubmed	Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS.	EEF2 AHNAK EXOSC6 DKC1 PARP14 TOP2B	8.20e-05	340	73	6	29478914
Pubmed	The ancestral gene for transcribed, low-copy repeats in the Prader-Willi/Angelman region encodes a large protein implicated in protein trafficking, which is deficient in mice with neuromuscular and spermiogenic abnormalities.	HERC2 HERC2P3	9.06e-05	7	73	2	9949213
Pubmed	Regulator of G protein signaling 12 drives inflammatory arthritis by activating synovial fibroblasts through MYCBP2/KIF2A signaling.	MYCBP2 HERC2	9.06e-05	7	73	2	36700049
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	RNGTT MYCBP2 ADRM1 PRPF3 AHNAK ATG2B PSMC3 HM13 WNK1 NXN ADCY6	9.34e-05	1321	73	11	27173435
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	BUD23 EEF2 MYCBP2 PRPF3 AHNAK PSMC3 DKC1 HUWE1 HERC2 SLC1A5 TOP2B	1.15e-04	1353	73	11	29467282
Pubmed	Saturation mutagenesis defines novel mouse models of severe spine deformity.	OR2A7 OR2A4	1.21e-04	8	73	2	34142127
Pubmed	BPA modulates the WDR5/TET2 complex to regulate ERβ expression in eutopic endometrium and drives the development of endometriosis.	EEF2 EPPK1 PSMC3 DKC1 ALDH4A1 HM13 PARP14 NXN	1.22e-04	711	73	8	33022573
Pubmed	Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes.	BUD23 EPPK1 MYCBP2 PRPF3 SRR HERC2 OGDH	1.30e-04	533	73	7	25544563
Pubmed	Discovery of tissue-specific exons using comprehensive human exon microarrays.	WNK1 OGDH	1.55e-04	9	73	2	17456239
Pubmed	Platelet alpha-granules.	CD36 GP5	1.55e-04	9	73	2	8467233
Pubmed	Identification of proteins associated with ligand-activated estrogen receptor α in human breast cancer cell nuclei by tandem affinity purification and nano LC-MS/MS.	EPPK1 AHNAK DNAH2 DKC1 TOP2B	1.69e-04	245	73	5	21182205
Pubmed	Prader-Willi Syndrome	NPAP1 HERC2	1.93e-04	10	73	2	20301505
Pubmed	Diphthamide deficiency promotes association of eEF2 with p53 to induce p21 expression and neural crest defects.	EEF2 ALDH4A1	1.93e-04	10	73	2	38671004
Pubmed	In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators.	BUD23 DNAJB12 EEF2 RNGTT ADRM1 PRPF3 EXOSC6 PSMC3 HUWE1	1.95e-04	971	73	9	33306668
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	DNAJB12 EEF2 PRPF3 AHNAK PSMC3 DKC1 HUWE1 OGDH SLC1A5 TOP2B HERC5	1.98e-04	1440	73	11	30833792
Pubmed	Branched ubiquitin chain binding and deubiquitination by UCH37 facilitate proteasome clearance of stress-induced inclusions.	ADRM1 PSMC3 HUWE1	2.04e-04	54	73	3	34761751
Pubmed	Proteomic analysis of the NOS2 interactome in human airway epithelial cells.	MYCBP2 PSMC3 TNFAIP2 HUWE1	2.09e-04	138	73	4	23438482
Pubmed	Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2.	EME1 RNGTT HERC2 HM13	2.15e-04	139	73	4	25476789
Pubmed	Characterization of SARS-CoV-2 proteins reveals Orf6 pathogenicity, subcellular localization, host interactions and attenuation by Selinexor.	EEF2 ADRM1 PSMC3 HUWE1 HM13 SLC1A5	2.20e-04	408	73	6	33766124
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	BRD8 EPPK1 PRPF3 AHNAK PSMC3 TNFAIP2 HUWE1	2.22e-04	582	73	7	20467437
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	BUD23 EEF2 AHNAK EXOSC6 PSMC3 DKC1 HUWE1 SLC1A5 TOP2B	2.23e-04	989	73	9	36424410
Pubmed	Ubiquitin ligase TRIM71 suppresses ovarian tumorigenesis by degrading mutant p53.	CUL9 HUWE1	2.36e-04	11	73	2	31570706
Pubmed	Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo.	RHBG CPS1	2.36e-04	11	73	2	20084116
Pubmed	Ubiquitinated proteins promote the association of proteasomes with the deubiquitinating enzyme Usp14 and the ubiquitin ligase Ube3c.	ADRM1 PSMC3	2.36e-04	11	73	2	28396413
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	SYNRG SALL2 RNGTT NOMO2 CUL9 HUWE1 WNK1	2.37e-04	588	73	7	38580884
Pubmed	Histone methyltransferase DOT1L coordinates AR and MYC stability in prostate cancer.	EEF2 EPPK1 MYCBP2 PSMC3 HUWE1	2.39e-04	264	73	5	32814769
Pubmed	A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-κB Signaling.	EEF2 ADRM1 EXOSC6 PSMC3 DKC1 HUWE1 SLC1A5 TOP2B	2.42e-04	786	73	8	29128334
Pubmed	Identification of different proteins binding to Na, K-ATPase α1 in LPS-induced ARDS cell model by proteomic analysis.	EEF2 PSMC3 CPS1 SLC1A5	2.46e-04	144	73	4	35681168
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	SALL2 MYCBP2 AHNAK ATG2B ZFHX3 HUWE1	2.51e-04	418	73	6	34709266
Pubmed	Isolation of human proteasomes and putative proteasome-interacting proteins using a novel affinity chromatography method.	ADRM1 PSMC3 HUWE1	2.52e-04	58	73	3	19013454
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	DNAJB12 MYCBP2 NOMO2 GHITM DDHD2 HERC2 HM13 OGDH SLC1A5 TOP2B HERC5	2.62e-04	1487	73	11	33957083
Pubmed	Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics.	AHNAK PSMC3 HUWE1 CPS1 HM13 OGDH	2.64e-04	422	73	6	27342126
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	DNAJB12 ZHX3 EEF2 BRD8 ADRM1 PRPF3 AHNAK DKC1 TOP2B	2.68e-04	1014	73	9	32416067
Pubmed	Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt.	EEF2 GHITM HUWE1 OGDH TOP2B	2.70e-04	271	73	5	25737280
Pubmed	Physiological and pathophysiological characteristics of ataxin-3 isoforms.	EEF2 PSMC3 HUWE1 OGDH SLC1A5	3.19e-04	281	73	5	30455355
Pubmed	Identification of atrogin-1-targeted proteins during the myostatin-induced skeletal muscle wasting.	EEF2 ADRM1 AHNAK PSMC3	3.25e-04	155	73	4	22673621
Pubmed	Insulin receptor substrate-4 interacts with ubiquitin-specific protease 18 to activate the Jak/STAT signaling pathway.	EEF2 HUWE1	3.34e-04	13	73	2	29285303
Pubmed	Evolution of odorant receptors expressed in mammalian testes.	OR2A7 OR2A4	3.34e-04	13	73	2	11014824
Pubmed	Alternative exon skipping biases substrate preference of the deubiquitylase USP15 for mysterin/RNF213, the moyamoya disease susceptibility factor.	MYCBP2 ADRM1 PRPF3	3.53e-04	65	73	3	28276505
Pubmed	Information coding in the olfactory system: evidence for a stereotyped and highly organized epitope map in the olfactory bulb.	OR2A7 OR2A4	3.89e-04	14	73	2	7528109
Pubmed	The ubiquitin ligase TRIM25 targets ERG for degradation in prostate cancer.	HUWE1 HERC2	3.89e-04	14	73	2	27626314
Pubmed	Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.	EME1 BRD8 MYCBP2 AHNAK ATG2B HUWE1 WNK1	4.13e-04	645	73	7	25281560
Pubmed	The p300/YY1/miR-500a-5p/HDAC2 signalling axis regulates cell proliferation in human colorectal cancer.	EEF2 AHNAK CPS1 HM13 WNK1	4.17e-04	298	73	5	30737378
Pubmed	SARS-CoV-2 nucleocapsid protein binds host mRNAs and attenuates stress granules to impair host stress response.	EEF2 EPPK1 PSMC3 DKC1 HUWE1 SLC1A5	4.32e-04	463	73	6	34901782
Pubmed	The deubiquitinase USP9X regulates FBW7 stability and suppresses colorectal cancer.	MYCBP2 HUWE1 HERC2	4.58e-04	71	73	3	29346117
Pubmed	PINK1 Content in Mitochondria is Regulated by ER-Associated Degradation.	EEF2 EPPK1 ADRM1 AHNAK HUWE1 SLC1A5	5.05e-04	477	73	6	31300519
Pubmed	UBR5 Acts as an Antiviral Host Factor against MERS-CoV via Promoting Ubiquitination and Degradation of ORF4b.	PSMC3 HUWE1	5.12e-04	16	73	2	35980206
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	CUL9 HUWE1 HERC2 SLC2A11 KIAA2013	5.21e-04	313	73	5	38270169
Pubmed	STING-Mediated IFI16 Degradation Negatively Controls Type I Interferon Production.	EEF2 PRPF3 EXOSC6 PSMC3 HERC5	5.44e-04	316	73	5	31665637
Pubmed	Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents.	EEF2 PRPF3 PSMC3 DKC1 HUWE1 HERC5	5.57e-04	486	73	6	30940648
Pubmed	Destabilization of Atoh1 by E3 Ubiquitin Ligase Huwe1 and Casein Kinase 1 Is Essential for Normal Sensory Hair Cell Development.	MYCBP2 HUWE1 HERC2	5.59e-04	76	73	3	27542412
Pubmed	The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs.	EEF2 EPPK1 PSMC3 SLC1A5 KIAA2013	5.76e-04	320	73	5	28685749
Pubmed	RBM4 dictates ESCC cell fate switch from cellular senescence to glutamine-addiction survival through inhibiting LKB1-AMPK-axis.	HUWE1 HERC5	5.79e-04	17	73	2	37080995
Pubmed	Quantitative interaction proteomics of neurodegenerative disease proteins.	DNAJB12 EEF2 EPPK1 PSMC3 SLC1A5	6.00e-04	323	73	5	25959826
Pubmed	Characterization of Dynamic UbR-Proteasome Subcomplexes by In vivo Cross-linking (X) Assisted Bimolecular Tandem Affinity Purification (XBAP) and Label-free Quantitation.	EEF2 ADRM1 PSMC3	6.03e-04	78	73	3	27114451
Pubmed	Proteomic analysis identifies novel binding partners of BAP1.	EEF2 HUWE1 CPS1	6.49e-04	80	73	3	34591877
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	EEF2 EPPK1 AHNAK PSMC3 HUWE1	6.79e-04	332	73	5	32786267
Pubmed	Transferrin Receptor Protein 1 Cooperates with mGluR2 To Mediate the Internalization of Rabies Virus and SARS-CoV-2.	ADRM1 PSMC3 DKC1 HUWE1 SLC1A5	6.89e-04	333	73	5	36779763
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	BUD23 EPPK1 PSMC3 ALDH4A1 HUWE1 CPS1 TOP2B	6.93e-04	704	73	7	29955894
Pubmed	Assembly pathway of the Mammalian proteasome base subcomplex is mediated by multiple specific chaperones.	ADRM1 PSMC3	7.26e-04	19	73	2	19490896
Pubmed	MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis.	ZHX3 SALL2 NOMO2 PRPF3 DKC1	7.46e-04	339	73	5	30415952
Pubmed	Evolutionarily conserved regulators of tau identify targets for new therapies.	DNAJB12 EEF2 ADRM1 NOMO2 PSMC3 HM13	7.61e-04	516	73	6	36610398
Pubmed	Human transcription factor protein interaction networks.	BUD23 ZHX3 BRD8 SALL2 ADRM1 PSMC3 CUL9 ZFHX3 HERC2 SLC1A5	7.83e-04	1429	73	10	35140242
Pubmed	LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow.	NOMO2 HUWE1 CPS1 WNK1 OGDH	7.97e-04	344	73	5	30333137
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	DNAJB12 ADRM1 DNAH2 PSMC3 HUWE1 HM13 SLC1A5 KIAA2013	7.99e-04	942	73	8	31073040
Pubmed	TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.	BUD23 EEF2 EPPK1 PRPF3 AHNAK DKC1 CPS1 HERC5	8.38e-04	949	73	8	36574265
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	AHNAK HERC2 PARP14 TOP2B	8.79e-04	202	73	4	33005030
Pubmed	Ubiquitin-protein ligase E3C maintains non-small-cell lung cancer stemness by targeting AHNAK-p53 complex.	EEF2 AHNAK	8.89e-04	21	73	2	30503554
GeneFamily	Solute carriers	RHBG SLC18A1 SLC22A2 SLC49A4 SLC13A5 SLC34A3 SLC1A5 SLC2A11	7.21e-06	395	47	8	752
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZHX3 ZFHX3	6.80e-04	15	47	2	529
ToppCell	facs-Tongue-nan-3m-Epithelial-nan\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EEF2 EPPK1 AHNAK HUWE1 OGDH TOP2B	9.24e-07	199	73	6	8d50e1ee58710d896c0204937331d9f4dcd38de0
ToppCell	Cerebellum-Macroglia-ASTROCYTE-Gja1-Bergmann_Glia_(Slc1a3)--\|Cerebellum / BrainAtlas - Mouse McCarroll V32	EME1 PMEL CPS1 QRICH2	1.34e-05	88	73	4	2075743c7c0b6d74e80464a6bc776206d744d502
ToppCell	Cerebellum-Macroglia-ASTROCYTE-Gja1-Bergmann_Glia_(Slc1a3)\|Cerebellum / BrainAtlas - Mouse McCarroll V32	EME1 PMEL CPS1 QRICH2	1.34e-05	88	73	4	a49319bc97188550e08248973e10c626124c3917
ToppCell	Cerebellum-Macroglia-ASTROCYTE-Gja1-Bergmann_Glia_(Slc1a3)-\|Cerebellum / BrainAtlas - Mouse McCarroll V32	EME1 PMEL CPS1 QRICH2	1.34e-05	88	73	4	14b11249a2b3fa327622897fe74630c2697ea47e
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 DCDC1 COL27A1 SLC22A2 TNFAIP2	1.48e-05	189	73	5	3b48b0d220cc24d5170713d61fa91f5bb6c21841
ToppCell	CD8+_Memory_T_cell-CV-7\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	MYCBP2 NOMO2 HUWE1 PARP14 SLC1A5	1.56e-05	191	73	5	9454f642c3621370fa23640b631301346b300950
ToppCell	facs-Aorta-Heart-3m\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GHITM ZFHX3 TNFAIP2 HERC2 TOP2B	1.59e-05	192	73	5	1ccc47792edf9ee23501c8e2165d11271636b66a
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-3_mon\|organoid_Paulsen_bioRxiv / Sample Type, Dataset, Time_group, and Cell type.	EEF2 THRA EXOSC6 HM13 ENDOV	1.68e-05	194	73	5	4903a0d6e36599bcb83b179462e5b949df9eb685
ToppCell	facs-Tongue-nan-3m-Epithelial\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPPK1 AHNAK HUWE1 OGDH TOP2B	1.85e-05	198	73	5	2f03f8897dd7cce6d8296638e14e11ec16bcf624
ToppCell	facs-Tongue-nan-3m\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPPK1 AHNAK HUWE1 OGDH TOP2B	1.85e-05	198	73	5	f2a4057f038ef7225a5b98a7ab068c30dff4eadd
ToppCell	mild-HLA-DR+_CD83+_Monocyte\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	AHNAK CD36 ZFHX3 TNFAIP2 PARP14	1.94e-05	200	73	5	934c2efc780318c66d667ca75be0de350361d351
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 COL27A1 SLC22A2 ALDH4A1 TNFAIP2	1.94e-05	200	73	5	105564ee05bd11685b5747ee32d5350cf3c2e2e1
Disease	metabolite measurement, diet measurement	AHNAK SLC22A2 SLC13A5 CPS1	2.50e-05	71	70	4	EFO_0004725, EFO_0008111
Disease	Prader-Willi syndrome	NPAP1 HERC2	2.47e-04	10	70	2	cv:C0032897
Disease	PRADER-WILLI SYNDROME	NPAP1 HERC2	2.47e-04	10	70	2	176270
Disease	Royer Syndrome	NPAP1 HERC2	3.61e-04	12	70	2	C0265222
Disease	Prader-Willi Syndrome	NPAP1 HERC2	4.25e-04	13	70	2	C0032897
Disease	amyotrophic lateral sclerosis, age at onset	SLC18A1 ST3GAL3	5.71e-04	15	70	2	EFO_0004847, MONDO_0004976
Disease	waist-hip ratio	PRUNE2 ZHX3 MEGF8 MYCBP2 AHNAK SLC22A2 CUL9 FAM124B WNK1 KIAA2013	6.07e-04	1226	70	10	EFO_0004343
Disease	blood phosphate measurement	ZHX3 DCDC1 ZFHX3 SLC34A3	7.91e-04	174	70	4	EFO_0010972
Disease	Myeloid Leukemia	ATG2B TOP2B	8.28e-04	18	70	2	C0023470
Disease	Leukemia, Monocytic, Chronic	ATG2B TOP2B	8.28e-04	18	70	2	C0023466
Disease	heart failure, diabetes mellitus, stroke, atrial fibrillation, mortality, coronary artery disease, cancer	DNAH2 ZFHX3	1.03e-03	20	70	2	EFO_0000275, EFO_0000400, EFO_0000712, EFO_0001645, EFO_0003144, EFO_0004352, MONDO_0004992
Disease	platelet component distribution width	PRUNE2 BRD8 MOV10L1 CPS1 WNK1 NXN GP5	2.07e-03	755	70	7	EFO_0007984

Protein segments in the cluster

Peptide	Gene	Start	Entry
IEGDLLLGDMGQGIP	BUD23	96	O43709
PVGQEVEGMNILGLV	SLC1A5	221	Q15758
VGGVLPMIHGGEIQQ	BRD8	236	Q9H0E9
GLNMGPVVAGVIGAR	ADCY6	1086	O43306
GGNLAGAPALMGNVV	ALDH4A1	216	P30038
PGIGVQGLEGNLQMP	AHNAK	5481	Q09666
GILGGVGPMHSLVQL	ATG2B	1886	Q96BY7
ISGMGQQGLVPPGID	QRICH2	331	Q9H0J4
GMELAAVGGPLVGLV	SLC34A3	511	Q8N130
QLVLGVQGPNLRSGM	DCDC1	1181	M0R2J8
MLVGQGAGLLGPAVV	NOMO2	1	Q5JPE7
ISGQIVLAGDPMQLG	MOV10L1	906	Q9BXT6
MGGEGLLPQNVGLLY	RNGTT	476	O60942
FLNMGAPLGVGLGLV	GHITM	241	Q9H3K2
LMQEAGAVPLLGGLL	HERC2	1151	O95714
MPVLNQVAGLLGSGE	EXOSC6	216	Q5RKV6
NLGMAPLGIAGQPIL	ENOX2	46	Q16206
LPINVGMLNGGQRID	DDHD2	646	O94830
GMAGVATLLLQLPGG	MEGF8	2776	Q7Z7M0
NNFAMLGLGDVVIPG	HM13	256	Q8TCT9
QLVAGQLMGLLPGLA	EPHA10	741	Q5JZY3
NMVLAGAISGLVGPL	OR2A7	196	Q96R45
LQPQEPQIGGEGMRG	NSUN6	396	Q8TEA1
VPLQGFAALEGMNGI	HUWE1	4306	Q7Z6Z7
VLVNNAGMGLVGPLE	RDH8	86	Q9NYR8
GIIPRMLSGLAGGDQ	OR10Z1	76	Q8NGY1
NMVLAGAISGLVGPL	OR2A4	196	O95047
GQLGNGGTRDQLMPL	HERC5	326	Q9UII4
PGGLQMLLVKEGVQN	PARP14	1011	Q460N5
RQNGIVLLLPHGMEG	OGDH	771	Q02218
GQILTMANPIIGNGG	CPS1	91	P31327
PDGLILGMGGQTALN	CPS1	501	P31327
LGVKNGILGAGMLPL	FAM124B	251	Q9H5Z6
VMGQVVGLRELLGGP	SLC2A11	171	Q9BYW1
GAVLAVFGGILMPVG	CD36	16	P16671
VFGGILMPVGDLLIQ	CD36	21	P16671
RLIHGGQMLNGLAGP	SLC49A4	146	Q96SL1
DGGLGVFVQLMPILI	DNAJB12	241	Q9NXW2
EDPMVGGVGGDVQIL	HAS2	231	Q92819
LMGKEGIVGPLGILG	COL27A1	1566	Q8IZC6
LPGVLFGEMGGLQEL	GP5	281	P40197
QIQGGLIGGAPGVEM	CUL9	1556	Q8IWT3
LIGGAPGVEMLGQLQ	CUL9	1561	Q8IWT3
PGLMPQVLLVDGNGV	ENDOV	116	Q8N8Q3
GNIMIDPVLGTVGFG	EEF2	201	P13639
LDPVLLQMEGGGQLL	EME1	256	Q96AY2
LQMEGGGQLLGALQT	EME1	261	Q96AY2
VHLGLLLGVGGQMQE	DKC1	231	O60832
IGQPRGNMLLVGIGG	DNAH2	2751	Q9P225
GTGPNVVLLGQMNEL	SLC13A5	226	Q86YT5
PLMVFGVLGLVAGGL	SLC22A2	496	O15244
RMHLGGQIPNGGTAL	SALL2	711	Q9Y467
PGLIGNANMVGLANL	PRPF3	221	O43395
QLAAVRGGGGMALPQ	PHETA1	126	Q8N4B1
LGLGEGPQLQILEEM	PRUNE2	2666	Q8WUY3
IPMVLINGAEGIGTG	TOP2B	866	Q02880
VMGINLVGPVGGAAA	SYNRG	421	Q9UMZ2
GIQGIPTLIMLDPQG	NXN	271	Q6DKJ4
MEQGLLPAGLGQALL	EPPK1	61	P58107
NGLMGRGNIPTLGSV	ST3GAL3	291	Q11203
GNLFGEMAQLAVGGP	MYCBP2	3221	O75592
LVDALVVPVGGGGML	SRR	176	Q9GZT4
PEVGGLMAVLAVVGG	HERC2P3	911	Q9BVR0
MPGQEAGLGQVPLIV	PMEL	586	P40967
LLVGNTIPGPQVIMG	NPAP1	996	Q9NZP6
VMAGVIPIQGGILNL	PLA2G2D	11	Q9UNK4
SQLMQLIGPAGLGGL	ADRM1	166	Q16186
GFIKGPMLQGLQGEG	C10orf55	41	Q5SWW7
VGELQGMGLGSLLPP	TNFAIP2	296	Q03169
GMPGVLGALLGVLVA	RHBG	346	Q9H310
LAGPQLVQMFIGDGA	PSMC3	251	P17980
GSLGVHPEGQQLLGM	THRA	391	P10827
SNLLVPMGGVGGQVQ	WNK1	1001	Q9H4A3
TGGGLLVTQPLMANG	ZHX3	421	Q9H4I2
NLQEMVLHVPTGGGG	ZFHX3	3496	Q15911
GLIGPNAGLGLAIGM	SLC18A1	391	P54219
GLVKVGAPGILQGMV	KIAA2013	441	Q8IYS2