Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionextracellular matrix structural constituent

TNC MFAP4 MFGE8

1.11e-03188223GO:0005201
GeneOntologyMolecularFunctionsulfotransferase activity

SULT6B1 DSEL

1.66e-0355222GO:0008146
GeneOntologyMolecularFunctiontransferase activity, transferring sulphur-containing groups

SULT6B1 DSEL

2.98e-0374222GO:0016782
GeneOntologyBiologicalProcesscellular response to abiotic stimulus

MFAP4 YBX3 GOT1 ATM MMP1

3.75e-05371225GO:0071214
GeneOntologyBiologicalProcesscellular response to environmental stimulus

MFAP4 YBX3 GOT1 ATM MMP1

3.75e-05371225GO:0104004
GeneOntologyBiologicalProcessresponse to abiotic stimulus

ECE1 TNC MFAP4 ACAA2 YBX3 GOT1 ATM MMP1

4.88e-051361228GO:0009628
GeneOntologyCellularComponentextracellular matrix

TNC ANGPTL1 MFAP4 MFGE8 ANGPT4 MMP1

4.53e-05656226GO:0031012
GeneOntologyCellularComponentexternal encapsulating structure

TNC ANGPTL1 MFAP4 MFGE8 ANGPT4 MMP1

4.61e-05658226GO:0030312
GeneOntologyCellularComponentcollagen-containing extracellular matrix

TNC ANGPTL1 MFAP4 MFGE8 ANGPT4

1.89e-04530225GO:0062023
Domain-

TNC ANGPTL1 MFAP4 ANGPT4

1.51e-08242244.10.530.10
DomainFibrinogen_a/b/g_C_2

TNC ANGPTL1 MFAP4 ANGPT4

1.51e-0824224IPR014715
DomainFibrinogen_C

TNC ANGPTL1 MFAP4 ANGPT4

2.49e-0827224PF00147
DomainFBG

TNC ANGPTL1 MFAP4 ANGPT4

3.36e-0829224SM00186
Domain-

TNC ANGPTL1 MFAP4 ANGPT4

3.88e-08302243.90.215.10
DomainFibrinogen_a/b/g_C_1

TNC ANGPTL1 MFAP4 ANGPT4

3.88e-0830224IPR014716
DomainFIBRINOGEN_C_2

TNC ANGPTL1 MFAP4 ANGPT4

5.08e-0832224PS51406
DomainFibrinogen_a/b/g_C_dom

TNC ANGPTL1 MFAP4 ANGPT4

5.08e-0832224IPR002181
DomainFIBRINOGEN_C_1

TNC ANGPTL1 MFAP4 ANGPT4

5.08e-0832224PS00514
DomainFibrinogen_CS

ANGPTL1 ANGPT4

2.24e-0419222IPR020837
DomainSulfotransferase_dom

SULT6B1 DSEL

8.14e-0436222IPR000863
DomainSulfotransfer_1

SULT6B1 DSEL

8.14e-0436222PF00685
Domain-

ECE1 MMP1

4.06e-03812223.40.390.10
DomainMetalloPept_cat_dom

ECE1 MMP1

4.06e-0381222IPR024079
DomainZINC_PROTEASE

ECE1 MMP1

5.88e-0398222PS00142
DomainEGF

TNC MFGE8

9.55e-03126222PF00008
Pubmed

Molecular cloning and characterization of a novel angiopoietin family protein, angiopoietin-3.

ANGPTL1 ANGPT4

3.82e-07222210025962
Pubmed

Angiopoietin-3 is tethered on the cell surface via heparan sulfate proteoglycans.

ANGPTL1 ANGPT4

1.15e-06322215280392
Pubmed

Biological characterization of angiopoietin-3 and angiopoietin-4.

ANGPTL1 ANGPT4

5.72e-06622215284220
Pubmed

Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2.

ANGPTL1 ANGPT4

8.01e-06722215542434
Pubmed

Identification of a novel human angiopoietin-like gene expressed mainly in heart.

ANGPTL1 ANGPT4

1.71e-051022212624729
Pubmed

Proteomics characterization of extracellular space components in the human aorta.

TNC MFAP4 MFGE8

3.52e-0510122320551380
Pubmed

Angiopoietins 3 and 4: diverging gene counterparts in mice and humans.

ANGPTL1 ANGPT4

3.99e-051522210051567
Pubmed

Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins.

TNC MFAP4 MFGE8

1.05e-0414622327068509
Pubmed

The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices.

TNC MFAP4 MFGE8

1.57e-0416722322159717
Pubmed

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.

TNC MFAP4 MFGE8

4.99e-0424822324006456
CytobandEnsembl 112 genes in cytogenetic band chr11q22

ATM MMP1

1.21e-03107222chr11q22
GeneFamilyFibrinogen C domain containing

TNC ANGPTL1 MFAP4 ANGPT4

1.40e-0925124554
GeneFamilyEndogenous ligands

KISS1 MMP1

1.04e-02237122542
CoexpressionDELYS_THYROID_CANCER_UP

ECE1 TNC MFGE8 ACAA2 MMP1

2.86e-05445225M3645
CoexpressionVERRECCHIA_RESPONSE_TO_TGFB1_C4

TNC MMP1

3.68e-0511222M566
CoexpressionLEE_LIVER_CANCER_HEPATOBLAST

TNC MMP1

8.01e-0516222M13123
CoexpressionTAVAZOIE_METASTASIS

KISS1 TNC MMP1

9.90e-05108223M2778
CoexpressionSMID_BREAST_CANCER_LUMINAL_B_DN

TNC MFAP4 MFGE8 YBX3 MMP1

1.06e-04587225M17572
CoexpressionNABA_MATRISOME_BLEO_FIBROTIC_LUNG

TNC MFAP4

1.27e-0420222MM17053
CoexpressionNABA_MATRISOME

TNC ANGPTL1 MFAP4 MFGE8 ANGPT4 MMP1

1.40e-041008226MM17056
CoexpressionNABA_MATRISOME

TNC ANGPTL1 MFAP4 MFGE8 ANGPT4 MMP1

1.54e-041026226M5889
CoexpressionAtlasdev gonad_e12.5_M_InterstitLeydig_MafB_top-relative-expression-ranked_1000

TNC ANGPTL1 MFAP4 MFGE8 ASXL3 ACAA2 TSPAN5

8.35e-06768227gudmap_dev gonad_e12.5_M_InterstitLeydig_MafB_1000
CoexpressionAtlasdev gonad_e11.5_M_GonadVasMes_Flk_k-means-cluster#1_top-relative-expression-ranked_1000

TNC MFAP4 MFGE8 ASXL3 TSPAN5

2.06e-05337225gudmap_dev gonad_e11.5_M_GonadVasMes_Flk_k1_1000
CoexpressionAtlasdev gonad_e13.5_F_VascAssocMesenchStromOvary_Sma_k-means-cluster#1_top-relative-expression-ranked_1000

MFGE8 ASXL3 TSPAN5 DSEL

9.92e-05240224gudmap_dev gonad_e13.5_F_VascAssocMesenchStromOvary_Sma_k1_1000
CoexpressionAtlasdev gonad_e13.5_F_VascAssocMesenchStromOvary_Sma_top-relative-expression-ranked_1000

MFAP4 MFGE8 ASXL3 ACAA2 TSPAN5 DSEL

1.22e-04797226gudmap_dev gonad_e13.5_F_VascAssocMesenchStromOvary_Sma_1000
CoexpressionAtlasdev gonad_e11.5_M_GonadVasMes_Flk_top-relative-expression-ranked_1000

TNC MFAP4 MFGE8 ASXL3 ACAA2 TSPAN5

1.50e-04827226gudmap_dev gonad_e11.5_M_GonadVasMes_Flk_1000
CoexpressionAtlasdev gonad_e12.5_M_InterstitLeydig_MafB_k-means-cluster#1_top-relative-expression-ranked_1000

TNC MFAP4 MFGE8 ASXL3

2.65e-04310224gudmap_dev gonad_e12.5_M_InterstitLeydig_MafB_k1_1000
ToppCell3'-Child09-12-SmallIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TNC ANGPTL1 MFAP4 MFGE8 DSEL

3.99e-08199225a272c54baf8de59c0f259e6498d144a0de8d8924
ToppCell5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TNC ANGPTL1 MFAP4 MFGE8

1.75e-06181224eea943fdcbef0bbaa8578f3296923e874893b405
ToppCell5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TNC ANGPTL1 MFAP4 MFGE8

1.75e-061812249c157de9d3403e092c907599f2a2c16db5b21131
ToppCelldroplet-Kidney-KIDNEY-30m-Epithelial-Epcam_____kidney_distal_convoluted_tubule_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRPM7 MFGE8 GOT1 UROC1

2.04e-06188224ab6fa1beff91584d9303c2a33735de89aae8d5cd
ToppCelldroplet-Kidney-nan-3m-Epithelial-Epcam_____kidney_distal_convoluted_tubule_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRPM7 MFGE8 GOT1 UROC1

2.08e-06189224ff637ae0afdb1fdc67451be7e1e4fe575fbcfff4
ToppCelldroplet-Kidney-nan-3m-Epithelial-kidney_distal_convoluted_tubule_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRPM7 MFGE8 GOT1 UROC1

2.08e-06189224e127e3be626bc513e151d41812f0b7adb89d5da6
ToppCell5'-Adult-Appendix-Mesenchymal-Pericytes-Contractile_pericyte_(PLN+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TNC ANGPTL1 MFAP4 MFGE8

2.08e-06189224b6bb4327b4560d07d2b728abcc5f144f428948a5
ToppCell5'-Adult-Appendix-Mesenchymal-Pericytes|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TNC ANGPTL1 MFAP4 MFGE8

2.08e-061892240daa8efac08dca9525d2b8d421952068cab4eb50
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TNC ANGPTL1 MFAP4 ANGPT4

2.08e-0618922445e588b2a4ad9e3ff74e22d9d627ed3571f3b8b8
ToppCellE18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TNC ANGPTL1 MFAP4 ANGPT4

2.17e-0619122475d2197076a9dfc868e8baf95bd4c5e44f438e3e
ToppCellE18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TNC ANGPTL1 MFAP4 ANGPT4

2.17e-061912244b50fdd310701251e64e16cd2d07ce03dbfd3e3e
ToppCellE15.5-Mesenchymal-mesenchymal_fibroblast-mesenchymal_alveolar_niche_cell|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

TNC ANGPTL1 MFAP4 ANGPT4

2.17e-06191224053b3664f509baa107feaf90730f80ebf9ac8f14
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TNC ANGPTL1 MFAP4 ANGPT4

2.17e-06191224b133ee1c0e58d00ddd2e4e05b01fd04947524c18
ToppCelldroplet-Kidney-nan-21m-Epithelial-Epcam_____kidney_distal_convoluted_tubule_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRPM7 MFGE8 GOT1 UROC1

2.26e-06193224b397c14ac1e34c6be3f25d4417d200bc518d3048
ToppCelldroplet-Kidney-nan-21m-Epithelial-kidney_distal_convoluted_tubule_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRPM7 MFGE8 GOT1 UROC1

2.26e-06193224241a60d1f0d5832638fb3e1e4b7afa7387ea3c75
ToppCelldroplet-Kidney-nan-18m-Epithelial-kidney_distal_convoluted_tubule_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRPM7 MFGE8 GOT1 UROC1

2.26e-06193224fa8bcf2a5ab7b08fae98a1466a936995142b4309
ToppCell3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TNC ANGPTL1 MFAP4 MFGE8

2.45e-0619722416758f181ef07c60aee63072e1da9572c5c85414
ToppCell10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-SMC_COL-F|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ECE1 TNC MFAP4 MFGE8

2.50e-06198224eb78b2ae6a787dbc75947e8dd5a03693285bc8be
ToppCellILEUM-inflamed-(8)_Fibroblast|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

TNC ANGPTL1 MFAP4 MFGE8

2.55e-06199224cb3c04b91c8e8080137823b11c76ca0a2adda52d
ToppCellmedial-mesenchymal-Myofibroblast|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

TNC ANGPTL1 MFAP4 ASXL3

2.55e-06199224e25acdb5809aaff631cb06dbe4c7e59549a0bdb9
ToppCellmedial-2-mesenchymal-Myofibroblast|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

TNC ANGPTL1 MFAP4 ASXL3

2.55e-0619922495aae608fa35a9c82b12c6f18937ce636750ca44
ToppCellmedial-mesenchymal-Myofibroblast-2|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

TNC ANGPTL1 MFAP4 ASXL3

2.55e-061992249ebf4822ff9fa08574edec5dbf4f2a1488f34b1d
ToppCell3'-Child04-06-SmallIntestine-Mesenchymal|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TNC ANGPTL1 MFAP4 MFGE8

2.55e-06199224a843bdfcb58bec5e2a94a5ec9d5b8c5e4aef15d2
ToppCellControl_saline-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast|Control_saline / Treatment groups by lineage, cell group, cell type

TNC ANGPTL1 MFAP4 ANGPT4

2.60e-06200224c5e051f1aac8dda376c342a9932785a23450e073
ToppCellMS-CD8-CD8_2|MS / Condition, Cell_class and T cell subcluster

ANGPTL1 ATM DSEL

5.34e-0515022301c20d787ce269db0d153e63a600a8d9ead61856
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TNC MFAP4 MFGE8

6.96e-0516422301a7c335897128d3478b8b9b44fb461cab493084
ToppCellPND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ANGPTL1 MFAP4 ANGPT4

7.61e-05169223031465190cd3623a25ef2b868daab8d932c8ff08
ToppCelldroplet-Skin-nan-18m-Epithelial-keratinocyte_stem_cell|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TNC MFAP4 MFGE8

7.74e-0517022310e0912dd0beab5d0bbe2bd49e477b5962687925
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_3-Exc_L3_THEMIS_PLA2G7|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TNC MFGE8 SLC5A8

8.01e-051722231d086e00cd549459d70e1d3b468d5ab6379f3bee
ToppCell367C-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-1|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

YBX3 ATM DSEL

8.15e-051732235d3c917e4d0de3158550a8ab2006ddfa87159ffa
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Degenerative_Vascular_Smooth_Muscle_Cell-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MFAP4 MFGE8 ANGPT4

8.72e-0517722388403b055eb9fdf96e4695fb6e0d78179e30a1e3
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Degenerative_Vascular_Smooth_Muscle_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MFAP4 MFGE8 ANGPT4

8.72e-051772238903aeaab61abd81a148ea623038c5114b8a183b
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ASXL3 GOT1 SLC5A8

8.87e-05178223dfed0fbf7a73b8a9e00178ec58dc4592b271c344
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ASXL3 GOT1 SLC5A8

9.02e-05179223d0fa700648db8ce76a8aa689879a25048299fa40
ToppCellILEUM-non-inflamed-(8)_Fibroblast-(8)_Activated_fibroblasts|(8)_Fibroblast / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

TSPAN5 GOT1 MMP1

9.02e-051792235787ffba96918db80256ced076a455a84ba01384
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ASXL3 GOT1 SLC5A8

9.02e-051792232e49b215b71438400aebb483f2c2c08d5e956961
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_119|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TNC MFAP4 MFGE8

9.17e-05180223ea7a1ccf0dd3bb5af5df87501f873e7339a824b3
ToppCell5'-Airway_Nasal-Mesenchymal-Fibroblastic|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TNC MFAP4 MMP1

9.17e-05180223935c091bbcd6d10b81dc4731779e5bd98205c99f
ToppCell5'-Airway_Nasal-Mesenchymal|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TNC MFAP4 MMP1

9.17e-051802233dd384b7f3d9582b8fec9fe05100e466e6218b76
ToppCellBronchial_Biopsy-Mesenchymal-Smooth_muscle|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X

MFAP4 MFGE8 ANGPT4

9.17e-051802237085a851807e6a833965e1366946db0bbc5174e2
ToppCell5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TNC ANGPTL1 MFAP4

9.32e-05181223b116c68393d8836bac080f81a8fcbeb52e0403e7
ToppCellcellseq-Mesenchymal-Chondrocytic-Mesenchymal_Airway/Vascular|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ANGPTL1 MFAP4 MFGE8

9.47e-05182223bb7de0c93d8f59f13c990e425139b9348ca8027e
ToppCell3'-Broncho-tracheal-Mesenchymal-Mesenchymal_Myocytic-tracheobronchial_smooth_muscle_cell-SM_activated_stress_response|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ANGPTL1 MFAP4 MFGE8

9.47e-051822231c1a687f728341c209b048b6715bcddd0ac20069
ToppCellcellseq-Mesenchymal-Chondrocytic-Mesenchymal_Airway/Vascular-Chondrocyte|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ANGPTL1 MFAP4 MFGE8

9.47e-05182223507f095af4dff60f2c2b64d750477154084c3595
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TNC MFAP4 MFGE8

9.47e-05182223af65f0fc3f9e5d9ce69ee5faaf5b6cb7f8412e0c
ToppCellcellseq-Mesenchymal-Chondrocytic|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ANGPTL1 MFAP4 MFGE8

9.47e-0518222388bd17c07bd8443a0ede4e9dc7bc9d1230b42211
ToppCell3'-Broncho-tracheal-Mesenchymal-Mesenchymal_Myocytic-tracheobronchial_smooth_muscle_cell-SM_activated_stress_response-SM_activated_stress_response_L.2.3.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ANGPTL1 MFAP4 MFGE8

9.47e-0518222397bb07478f56a937b490fba121ee603db64134a1
ToppCellNS-moderate-d_16-33-Lymphoid-NK|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

TNC MFAP4 MMP1

9.47e-05182223fb503f8ecd013f1f2161a5841572b57cfcddb6fa
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TNC MFAP4 MFGE8

9.47e-05182223b7d532feb73167e05475855061b35a209583f44c
ToppCell5'-Airway_Nasal-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TNC MFAP4 MMP1

9.63e-051832236d98973098c6d20c5305bce6a83a549a7d8dbfba
ToppCell5'-Airway_Nasal-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TNC MFAP4 MMP1

9.63e-05183223cc7f5a17b40e8d901885174922e5fa8877643071
ToppCell5'-Airway_Nasal-Mesenchymal-Fibroblastic-fibroblastic_type_2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TNC MFAP4 MMP1

9.63e-05183223803376f5260de83c48d4f7301278d078a32b3e6e
ToppCelldroplet-Kidney-KIDNEY-1m-Epithelial-Epcam_____kidney_distal_convoluted_tubule_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRPM7 MFGE8 UROC1

9.63e-05183223f3728b1a51951c7349f77a3e4d2671ca3a8d2a44
ToppCell5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ANGPTL1 MFAP4 MFGE8

9.63e-05183223bc7dd6a40ec9c773d005c1a46f305d40cdd0a326
ToppCell5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-tracheobronchial_smooth_muscle_cell-Fibromyocytes-Fibromyocytes_L.2.3.2.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TNC ANGPTL1 MFGE8

9.79e-051842237b5678718719020b52e7c2a7bd9797987defd7ff
ToppCell5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-tracheobronchial_smooth_muscle_cell-Fibromyocytes|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TNC ANGPTL1 MFGE8

9.79e-0518422354e5b63f55b8d6eccad53d389ea9c78f991e1414
ToppCelldroplet-Kidney-KIDNEY-1m-Epithelial-kidney_distal_convoluted_tubule_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRPM7 MFGE8 UROC1

9.79e-051842238939b6d795992775df0ff58ed1ec9d421a00bcc4
ToppCell3'-Distal_airway-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TNC ANGPTL1 MFAP4

9.94e-051852237b1c5d99bd7a6e148524029758cee244a17f5d09
ToppCellmoderate-Lymphoid-NK|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

TNC MFAP4 MMP1

9.94e-051852234979a787acbc9b4ca8defe91cc79b674e51af1bf
ToppCellLPS_only-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TNC MFAP4 ANGPT4

9.94e-05185223e64e8c98dd88d91f6501d3fb10b60fd2f3c90af3
ToppCell3'-Distal_airway-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TNC ANGPTL1 MFAP4

9.94e-05185223e9033a03d574956cf3ae228740b3166e40a6397f
ToppCellE17.5-Mesenchymal-mesenchymal_fibroblast-mesenchymal_alveolar_niche_cell|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

MFAP4 ANGPT4 TSPAN5

9.94e-05185223c85bba1210f1d389add3e40be9b96abac40cf8c1
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM7 GOT1 PKP4

9.94e-0518522303f64a7132b13a01ba47187e0e15c13ac88f7cb2
ToppCellControl-Epithelial-Basal|Epithelial / Disease state, Lineage and Cell class

ECE1 ASXL3 MMP1

9.94e-05185223d5d6d13e2f20b54ca55645b9a757b8599f4fd897
ToppCell3'-Distal_airway-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TNC ANGPTL1 MFAP4

9.94e-05185223578f12c6b2e33d09598dc8e022a20c8555d1325c
ToppCellP03|World / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

TNC MFAP4 ACAA2

9.94e-05185223a07dbe1f76e40734a28826423a5cc64b8e56af5e
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TNC MFAP4 ANGPT4

1.01e-041862236add08d4ca019ff2864acdd5ec2c66a59a574591
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro2_(5)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

TNC ANGPTL1 MFAP4

1.01e-041862237def03dd856b765bd3f493288641981c4f7fd26e
ToppCell3'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TNC MFAP4 MFGE8

1.01e-04186223d3509a579871ba6a8c4edd6137b28f271c9dbe70
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

TBC1D30 GOT1 PKP4

1.03e-04187223b93cf4dfe8ffb89348ee7bccc9f284189f7240a2
ToppCell3'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ANGPTL1 MFAP4 MFGE8

1.03e-041872236f47a80e612b320f571210483e62ff5db2a8ea43
ToppCell3'-Adult-LargeIntestine-Mesenchymal-stromal_related-T_reticular|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ANGPTL1 MFAP4 MFGE8

1.03e-04187223f0c4d93f75615e570e4465fd622e3124189618a1
ToppCell3'-Adult-LargeIntestine-Mesenchymal-stromal_related|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ANGPTL1 MFAP4 MFGE8

1.03e-041872233ff57da09ed8394913fb683669d7bff84a936623
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ANGPTL1 MFAP4 MFGE8

1.04e-04188223e18065bbc26d6f3774fd1f478fb41d8fb555fa26
ToppCelldroplet-Kidney-KIDNEY-30m-Epithelial-kidney_distal_convoluted_tubule_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRPM7 GOT1 UROC1

1.04e-04188223d2d2b6c49448da24f457cedcd213f68841834a99
ToppCellnormal_Lung-Fibroblasts-Smooth_muscle_cells|normal_Lung / Location, Cell class and cell subclass

TNC MFAP4 MFGE8

1.04e-04188223fd70fb89570f014d1299c60fe017dc09f24e57c6
ToppCellLPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TNC MFAP4 ANGPT4

1.04e-04188223293f2fa99f5f96aa7fd2b2a5cc94ff60eeaabe11
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Degenerative_Fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TNC MFAP4 MFGE8

1.06e-041892239e1a51997ef9b6999d9b40cf0a55e561e3b4a84c
ToppCellmoderate-Lymphoid-NK|Lymphoid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

TNC MFAP4 MMP1

1.06e-0418922322a19365782003c18ec8dddcdbfdaa82c4e330f6
ToppCellLPS_only-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TNC MFAP4 TSPAN5

1.06e-041892232a22b9fae70afb3dab8476f9c00e48a4df756410
ToppCellnormal_Lung-Fibroblasts-Undetermined|normal_Lung / Location, Cell class and cell subclass

ANGPTL1 MFAP4 MFGE8

1.08e-0419022330d4658bcc6796f0cdf54cc029f4bb904b13ef66
ToppCellIPF-Epithelial-Basal|Epithelial / Disease state, Lineage and Cell class

ECE1 TNC MMP1

1.08e-041902234f15842b424eefadbfe451875e517cf70e29607f
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_119|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TNC MFAP4 MFGE8

1.08e-041902237f6dafd5418764d67f6d5ec2153233b791910e81
ToppCellBasal_cells-IPF_02|World / lung cells shred on cell class, cell subclass, sample id

ECE1 TNC MMP1

1.09e-04191223a98915bad9a4a61dd4cbca798914849b805f4a19
ToppCell3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-tracheobronchial_smooth_muscle_cell-Fibromyocytes|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TNC MFAP4 MFGE8

1.09e-041912232a107e9096eb58b81b3da61547904d85754f6b2f
ToppCellASK440-Mesenchymal-Fibroblast|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq

TNC ANGPTL1 MFAP4

1.09e-04191223387296b5377ef6839f0812e5b3529a10b5f7d530
ToppCellASK440-Mesenchymal|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq

TNC ANGPTL1 MFAP4

1.09e-04191223f12959eebb4167e1aa03de05d7711a702c58b3c9
ToppCell3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-tracheobronchial_smooth_muscle_cell-Fibromyocytes-Fibromyocytes_L.2.3.2.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TNC MFAP4 MFGE8

1.09e-04191223d35692c652977500a3c36aa26c347a072b71e441
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ANGPTL1 MFAP4 MFGE8

1.11e-04192223b9e4585bea280ca0ae159f0c6a2bf7b88a15a6e6
ToppCelldroplet-Kidney-nan-18m-Epithelial-Epcam_____kidney_distal_convoluted_tubule_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRPM7 MFGE8 UROC1

1.11e-041922236fb56d062c35617b18b927704bf5fba894faed81
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ANGPTL1 MFAP4 MFGE8

1.11e-04192223c5f8e766453f87847b740d6988c524b3d0ef3765
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM7 GOT1 PKP4

1.11e-0419222332e4a180037e516c5cc798cd9dada9385e0f43ae
ToppCell3'_v3-lymph-node_spleen-Lymphocytic_T_CD8|lymph-node_spleen / Manually curated celltypes from each tissue

YBX3 ATM DSEL

1.11e-04192223ab88ea7723f0fa3b39611981c043445f27425404
ToppCell3'-Adult-LargeIntestine-Mesenchymal-fibroblastic-mLN_Stroma_(FMO2+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ANGPTL1 MFAP4 MFGE8

1.11e-0419222311867f30f0b420c18cb0b34d3990237aa737a0e8
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TNC MFAP4 ASXL3

1.13e-04193223fb28717fadd06c3840636d25409ce80c9254bd34
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TNC MFAP4 MFGE8

1.13e-04193223dc8e62df6121ee99b156aca6b1b3ae555739b6f2
ToppCellControl-CD8+_T_naive|Control / Disease condition and Cell class

YBX3 ATM DSEL

1.13e-04193223627d345baf1940218c61907305705298e473dbab
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.4.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TNC ANGPTL1 MFAP4

1.13e-041932235bee7abc550ddaa28cbb3b9ecaf6b924ab175de0
ToppCellCOVID-19_Severe-CD8+_T_naive|COVID-19_Severe / Disease condition and Cell class

YBX3 ATM DSEL

1.13e-041932238ece109352d67b6a76bc87a2579e299c77c63137
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_119|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TNC MFAP4 MFGE8

1.13e-04193223e2ee077fd381bd906e6b4329f22e7d106e422a7f
Drug2-methyl-5-nitroimidazole

ECE1 TNC

5.34e-064222CID000012760
Drug1,2-DAA

ATM MMP1

8.90e-065222CID000015652
DrugNSC755840

MFGE8 GOT1 DSEL

1.88e-0554223CID000002117
DrugA-432411

ECE1 MMP1

2.49e-058222CID010125830
DrugPimozide [2062-78-4]; Down 200; 8.6uM; HL60; HG-U133A

TBC1D30 ACAA2 PKP4 ATM

3.12e-051912241562_DN
DrugNialamide [51-12-7]; Down 200; 13.4uM; MCF7; HT_HG-U133A

TBC1D30 ECE1 MFGE8 ACAA2

3.38e-051952243871_DN
DrugDextromethorphan hydrobromide monohydrate [6700-34-1]; Up 200; 10.8uM; PC3; HT_HG-U133A

TBC1D30 KISS1 ANGPT4 PKP4

3.59e-051982246300_UP
DrugMinoxidil [38304-91-5]; Up 200; 19.2uM; PC3; HG-U133A

ECE1 MFGE8 ACAA2 PKP4

3.73e-052002241914_UP
Drugcarvacrol

TRPM7 SLC5A8

5.85e-0512222CID000010364
DrugRgd Peptide

TNC MFAP4 MFGE8 MMP1

7.46e-05239224CID000104802
Diseasepulmonary hypertension (implicated_via_orthology)

ECE1 TNC MMP1

8.70e-0654223DOID:6432 (implicated_via_orthology)
Diseasedilated cardiomyopathy (is_marker_for)

ECE1 MMP1

3.87e-0439222DOID:12930 (is_marker_for)
Diseasecongestive heart failure (implicated_via_orthology)

ECE1 MMP1

4.28e-0441222DOID:6000 (implicated_via_orthology)
DiseaseGastric Adenocarcinoma

TRPM7 ATM

5.15e-0445222C0278701
DiseaseAsthma

TNC MMP1

1.62e-0380222C0004096
Diseasecoronary artery disease (is_implicated_in)

ECE1 MMP1

2.51e-03100222DOID:3393 (is_implicated_in)
Diseaseurinary bladder cancer (is_marker_for)

KISS1 MMP1

2.87e-03107222DOID:11054 (is_marker_for)
Diseasememory performance

TBC1D30 SLC5A8 DSEL

3.35e-03409223EFO_0004874
Diseasehypertension (is_implicated_in)

ECE1 MMP1

3.65e-03121222DOID:10763 (is_implicated_in)

Protein segments in the cluster

PeptideGeneStartEntry
QNLSAGNWKFAAYIR

PKP4

851

Q99569
FFRNWENYKKGFGNI

ANGPTL1

331

O95841
ALNNEFFAYAAQGWK

ASXL3

306

Q9C0F0
FFAYAAQGWKQRLAE

ASXL3

311

Q9C0F0
YARLDKQGNFNAWVA

MFGE8

266

Q08431
NYNWNSFGLRFGKRE

KISS1

111

Q15726
NNFFQDLAWRDLFNK

PACS2

606

Q86VP3
QGKYLNWDAVFRFLQ

ATM

51

Q13315
FAFYNGEWDLAQKAL

FAM126A

246

Q9BYI3
GADFLARWYNGTNNK

GOT1

116

P17174
NFQRNWKDYKQGFGD

ANGPT4

341

Q9Y264
DNGGLKAAYRAYQNW

ECE1

671

P42892
ADFAAKWNEIYGNNL

DSEL

111

Q8IZU8
RYFDFAINWNKHLDG

SULT6B1

181

Q6IMI4
RFFKGNKYWAVQGQN

MMP1

341

P03956
FNGSVSFFRGWNDYK

MFAP4

86

P55083
AYDGGRLNFWNFNPN

SLC5A8

221

Q8N695
SQQRWKAANDAGYFN

ACAA2

186

P42765
KWFNVRNGYGFINRN

YBX3

96

P16989
NRLAEEKFFFWDYGN

UROC1

391

Q96N76
FLRRKNGRENFYQNW

TNC

2026

P24821
NGRENFYQNWKAYAA

TNC

2031

P24821
FYQNWKAYAAGFGDR

TNC

2036

P24821
NGFQQWYDALKAVAR

TBC1D30

231

Q9Y2I9
AFGADDWNLNIYFNC

TSPAN5

156

P62079
LRFGAKWNFANAYDN

TRPM7

941

Q96QT4