Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR2C1 ADGRG7 OR52B4 OR1M1 OR8H3 OR2F2 GPR26 GPR32 OR51M1 OR6C1 AGTR1 OR4K1 MRGPRX3 MRGPRX4 OR52M1 OR2F1 OR2B6 OR2AJ1 OR11H6 OR2AG1	4.10e-09	884	94	20	GO:0004930
GeneOntologyMolecularFunction	olfactory receptor activity	OR2C1 OR52B4 OR1M1 OR8H3 OR2F2 OR51M1 OR6C1 OR4K1 OR52M1 OR2F1 OR2B6 OR2AJ1 OR11H6 OR2AG1	1.40e-08	431	94	14	GO:0004984
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	OR2C1 ADGRG7 OR52B4 OR1M1 OR8H3 OR2F2 GPR26 GPR32 OR51M1 OR6C1 AGTR1 OR4K1 MRGPRX3 MRGPRX4 OR52M1 OR2F1 OR2B6 OR2AJ1 OR11H6 OR2AG1	3.89e-06	1353	94	20	GO:0004888
GeneOntologyMolecularFunction	N-acylphosphatidylethanolamine-specific phospholipase D activity	PLD1 PLD2	6.56e-05	3	94	2	GO:0070290
GeneOntologyMolecularFunction	cytoskeletal motor activity	KIF26A MYO1H DNAH2 DNAH9 KIF20B	2.39e-04	118	94	5	GO:0003774
GeneOntologyMolecularFunction	microtubule motor activity	KIF26A DNAH2 DNAH9 KIF20B	3.33e-04	70	94	4	GO:0003777
GeneOntologyMolecularFunction	phospholipase D activity	PLD1 PLD2	6.03e-04	8	94	2	GO:0004630
GeneOntologyBiologicalProcess	sensory perception of smell	OR2C1 OR52B4 OR1M1 OR8H3 OR2F2 OR51M1 OR6C1 OR4K1 UBR3 OR52M1 OR2F1 OR2B6 OR2AJ1 OR11H6 OR2AG1	2.11e-09	465	92	15	GO:0007608
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of smell	OR2C1 OR52B4 OR1M1 OR8H3 OR2F2 OR51M1 OR6C1 OR4K1 OR52M1 OR2F1 OR2B6 OR2AJ1 OR11H6 OR2AG1	7.22e-09	432	92	14	GO:0050911
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	OR2C1 OR52B4 OR1M1 OR8H3 OR2F2 OR51M1 OR6C1 OR4K1 UBR3 OR52M1 OR2F1 OR2B6 OR2AJ1 OR11H6 OR2AG1	1.87e-08	547	92	15	GO:0007606
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception	OR2C1 OR52B4 OR1M1 OR8H3 OR2F2 OR51M1 OR6C1 OR4K1 OR52M1 OR2F1 OR2B6 OR2AJ1 OR11H6 OR2AG1	3.09e-08	485	92	14	GO:0050907
GeneOntologyBiologicalProcess	detection of chemical stimulus	OR2C1 OR52B4 OR1M1 OR8H3 OR2F2 OR51M1 OR6C1 OR4K1 OR52M1 OR2F1 OR2B6 OR2AJ1 OR11H6 OR2AG1	8.05e-08	524	92	14	GO:0009593
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	OR2C1 ADGRG7 OR52B4 OR1M1 OR8H3 OR2F2 ADCY4 GPR26 GPR32 OR51M1 OR6C1 AGTR1 OR4K1 MRGPRX3 MRGPRX4 PLD2 OR52M1 OR2F1 OR2B6 OR2AJ1 OR11H6 OR2AG1	1.47e-07	1395	92	22	GO:0007186
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	OR2C1 OR52B4 OR1M1 OR8H3 OR2F2 OR51M1 OR6C1 OR4K1 OR52M1 OR2F1 OR2B6 OR2AJ1 OR11H6 OR2AG1	2.89e-07	582	92	14	GO:0050906
GeneOntologyBiologicalProcess	detection of stimulus	OR2C1 OR52B4 OR1M1 OR8H3 OR2F2 OR51M1 OR6C1 OR4K1 OR52M1 OR2F1 OR2B6 OR2AJ1 OR11H6 OR2AG1	3.68e-06	722	92	14	GO:0051606
GeneOntologyBiologicalProcess	sensory perception	OR2C1 OR52B4 OR1M1 OR8H3 OR2F2 OR51M1 OR6C1 OR4K1 UBR3 OR52M1 OR2F1 OR2B6 OR2AJ1 OR11H6 OR2AG1	7.53e-05	1072	92	15	GO:0007600
GeneOntologyBiologicalProcess	response to chloroquine	MRGPRX3 MRGPRX4	1.95e-04	5	92	2	GO:1902349
GeneOntologyBiologicalProcess	regulation of anion channel activity	TCAF2 TCAF1	2.92e-04	6	92	2	GO:0010359
GeneOntologyBiologicalProcess	chemosensory behavior	UBR3 MRGPRX3 MRGPRX4	3.53e-04	31	92	3	GO:0007635
Domain	7tm_1	OR2C1 OR52B4 OR1M1 OR8H3 OR2F2 GPR26 GPR32 OR51M1 OR6C1 AGTR1 OR4K1 MRGPRX3 MRGPRX4 OR52M1 OR2F1 OR2B6 OR2AJ1 OR11H6 OR2AG1	6.31e-10	677	92	19	PF00001
Domain	G_PROTEIN_RECEP_F1_1	OR2C1 OR52B4 OR1M1 OR8H3 OR2F2 GPR26 GPR32 OR51M1 OR6C1 AGTR1 OR4K1 MRGPRX3 MRGPRX4 OR52M1 OR2F1 OR2B6 OR2AJ1 OR11H6 OR2AG1	7.68e-10	685	92	19	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR2C1 OR52B4 OR1M1 OR8H3 OR2F2 GPR26 GPR32 OR51M1 OR6C1 AGTR1 OR4K1 MRGPRX3 MRGPRX4 OR52M1 OR2F1 OR2B6 OR2AJ1 OR11H6 OR2AG1	8.88e-10	691	92	19	PS50262
Domain	GPCR_Rhodpsn	OR2C1 OR52B4 OR1M1 OR8H3 OR2F2 GPR26 GPR32 OR51M1 OR6C1 AGTR1 OR4K1 MRGPRX3 MRGPRX4 OR52M1 OR2F1 OR2B6 OR2AJ1 OR11H6 OR2AG1	9.09e-10	692	92	19	IPR000276
Domain	GPCR_Rhodpsn_7TM	OR2C1 OR52B4 OR1M1 OR8H3 OR2F2 GPR26 GPR32 OR51M1 OR6C1 AGTR1 OR4K1 MRGPRX3 MRGPRX4 OR52M1 OR2F1 OR2B6 OR11H6 OR2AG1	3.79e-09	670	92	18	IPR017452
Domain	Olfact_rcpt	OR2C1 OR52B4 OR1M1 OR8H3 OR2F2 OR51M1 OR6C1 OR4K1 OR52M1 OR2F1 OR2B6 OR2AJ1 OR11H6 OR2AG1	7.53e-09	393	92	14	IPR000725
Domain	Gal_Oxidase_b-propeller	KLHL11 KLHL3 KLHL2 KLHL1	2.28e-05	34	92	4	IPR015916
Domain	Peptidase_M60_dom	TCAF2 TCAF1	2.40e-05	2	92	2	IPR031161
Domain	Peptidase_M60	TCAF2 TCAF1	2.40e-05	2	92	2	PF13402
Domain	M60-like	TCAF2 TCAF1	2.40e-05	2	92	2	SM01276
Domain	PLipase_D1/D2	PLD1 PLD2	2.40e-05	2	92	2	IPR016555
Domain	PLipase_D_fam	PLD1 PLD2	2.40e-05	2	92	2	IPR015679
Domain	PEPTIDASE_M60	TCAF2 TCAF1	2.40e-05	2	92	2	PS51723
Domain	PLDc_2	PLD1 PLD2	7.18e-05	3	92	2	PF13091
Domain	PLD-like_dom	PLD1 PLD2	7.18e-05	3	92	2	IPR025202
Domain	PLDc	PLD1 PLD2	1.43e-04	4	92	2	PF00614
Domain	Kelch	KLHL11 KLHL3 KLHL2 KLHL1	1.91e-04	58	92	4	SM00612
Domain	Gal_Oxase/kelch_b-propeller	KLHL11 KLHL3 KLHL2 KLHL1	2.04e-04	59	92	4	IPR011043
Domain	BACK	KLHL11 KLHL3 KLHL2 KLHL1	2.18e-04	60	92	4	SM00875
Domain	BACK	KLHL11 KLHL3 KLHL2 KLHL1	2.32e-04	61	92	4	PF07707
Domain	BACK	KLHL11 KLHL3 KLHL2 KLHL1	2.32e-04	61	92	4	IPR011705
Domain	BTB	KLHL11 KLHL3 KLHL2 KLHL1 KCNG4 ZBTB4	2.65e-04	180	92	6	SM00225
Domain	BTB/POZ_dom	KLHL11 KLHL3 KLHL2 KLHL1 KCNG4 ZBTB4	3.07e-04	185	92	6	IPR000210
Domain	-	KLHL3 KLHL2 KLHL1	3.11e-04	27	92	3	2.130.10.80
Domain	SKP1/BTB/POZ	KLHL11 KLHL3 KLHL2 KLHL1 KCNG4 ZBTB4	3.44e-04	189	92	6	IPR011333
Domain	PLDc	PLD1 PLD2	3.55e-04	6	92	2	SM00155
Domain	Kelch_1	KLHL11 KLHL3 KLHL2 KLHL1	3.94e-04	70	92	4	PF01344
Domain	Kelch_1	KLHL11 KLHL3 KLHL2 KLHL1	3.94e-04	70	92	4	IPR006652
Domain	BTB	KLHL11 KLHL3 KLHL2 KLHL1 ZBTB4	4.75e-04	131	92	5	PF00651
Domain	PLipase_D/transphosphatidylase	PLD1 PLD2	4.96e-04	7	92	2	IPR001736
Domain	PLD	PLD1 PLD2	4.96e-04	7	92	2	PS50035
Domain	DHC_N1	DNAH2 DNAH9	6.59e-04	8	92	2	PF08385
Domain	Dynein_heavy_dom-1	DNAH2 DNAH9	6.59e-04	8	92	2	IPR013594
Domain	BTB	KLHL11 KLHL3 KLHL2 KLHL1 ZBTB4	1.17e-03	160	92	5	PS50097
Domain	MRGPCRFAMILY	MRGPRX3 MRGPRX4	1.28e-03	11	92	2	IPR026234
Domain	ARM-type_fold	PDS5B NCAPD3 URB1 THADA TRPC4AP APC2 USP24	1.43e-03	339	92	7	IPR016024
Domain	Class_I_gatase-like	TCAF2 TCAF1	1.53e-03	12	92	2	IPR029062
Domain	Dynein_heavy_chain_D4_dom	DNAH2 DNAH9	2.10e-03	14	92	2	IPR024317
Domain	Dynein_HC_stalk	DNAH2 DNAH9	2.10e-03	14	92	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH2 DNAH9	2.10e-03	14	92	2	IPR013602
Domain	DHC_N2	DNAH2 DNAH9	2.10e-03	14	92	2	PF08393
Domain	MT	DNAH2 DNAH9	2.10e-03	14	92	2	PF12777
Domain	AAA_8	DNAH2 DNAH9	2.10e-03	14	92	2	PF12780
Domain	ATPase_dyneun-rel_AAA	DNAH2 DNAH9	2.10e-03	14	92	2	IPR011704
Domain	AAA_5	DNAH2 DNAH9	2.10e-03	14	92	2	PF07728
Domain	DHC_fam	DNAH2 DNAH9	2.42e-03	15	92	2	IPR026983
Domain	Dynein_heavy_dom	DNAH2 DNAH9	2.42e-03	15	92	2	IPR004273
Domain	Dynein_heavy	DNAH2 DNAH9	2.42e-03	15	92	2	PF03028
Pathway	KEGG_OLFACTORY_TRANSDUCTION	OR2C1 OR52B4 OR1M1 OR8H3 OR2F2 OR51M1 OR6C1 OR4K1 OR52M1 OR2F1 OR2B6 OR11H6 OR2AG1	4.20e-08	389	69	13	M14091
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR2C1 OR1M1 OR8H3 OR2F2 OR51M1 OR6C1 OR4K1 OR52M1 OR2F1 OR2B6 OR2AJ1 OR11H6 OR2AG1	9.45e-08	417	69	13	M4072
Pathway	REACTOME_SENSORY_PERCEPTION	OR2C1 OR1M1 OR8H3 OR2F2 OR51M1 OR6C1 OR4K1 OR52M1 OR2F1 OR2B6 OR2AJ1 OR11H6 OR2AG1	1.06e-05	636	69	13	M41834
Pathway	WP_GPCRS_ODORANT	OR2C1 ADGRG7 OR1M1 GPR26 MRGPRX3 MRGPRX4 OR2B6	1.12e-05	157	69	7	MM15872
Pathway	WP_GPCRS_CLASS_A_RHODOPSINLIKE	OR2C1 OR2F2 GPR32 AGTR1 OR2F1 OR2B6 OR2AG1	2.73e-04	260	69	7	M39397
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR2C1 OR2F2 OR2F1 OR11H6	3.78e-04	70	69	4	MM14984
Pathway	BIOCARTA_CB1R_PATHWAY	PLD1 PLD2	4.88e-04	7	69	2	MM1569
Pathway	BIOCARTA_CB1R_PATHWAY	PLD1 PLD2	4.88e-04	7	69	2	M22054
Pathway	REACTOME_SYNTHESIS_OF_PG	PLD1 PLD2	6.49e-04	8	69	2	M26961
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR2C1 OR52B4 OR1M1 OR8H3 OR2F2 OR51M1 OR6C1 OR4K1 OR52M1 OR2F1 OR2B6 OR2AJ1 OR11H6 OR2AG1	5.58e-13	340	95	14	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR2C1 OR52B4 OR1M1 OR8H3 OR2F2 OR51M1 OR6C1 OR4K1 OR52M1 OR2F1 OR2B6 OR2AJ1 OR11H6 OR2AG1	5.58e-13	340	95	14	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR2C1 OR52B4 OR1M1 OR8H3 OR2F2 OR51M1 OR6C1 OR4K1 OR52M1 OR2F1 OR2B6 OR2AJ1 OR11H6 OR2AG1	6.29e-13	343	95	14	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR2C1 OR52B4 OR1M1 OR8H3 OR2F2 OR51M1 OR6C1 OR4K1 OR52M1 OR2F1 OR2B6 OR2AJ1 OR11H6 OR2AG1	7.08e-13	346	95	14	14611657
Pubmed	The human olfactory receptor gene family.	OR2C1 OR52B4 OR1M1 OR8H3 OR2F2 OR51M1 OR4K1 OR52M1 OR2F1 OR2B6 OR2AJ1 OR11H6 OR2AG1	2.95e-09	541	95	13	14983052
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	CYC1 PDS5B NCAPD3 TMEM201 URB1 TCAF1 NAA25 THADA IARS1 USP24 DNAH2 SCAMP3 TMEM214 FANCA	2.78e-07	942	95	14	31073040
Pubmed	Update on the Kelch-like (KLHL) gene family.	KLHL11 KLHL3 KLHL2 KLHL1	4.90e-06	41	95	4	23676014
Pubmed	β-1,3-Glucan-induced host phospholipase D activation is involved in Aspergillus fumigatus internalization into type II human pneumocyte A549 cells.	PLD1 PLD2	7.38e-06	2	95	2	21760893
Pubmed	Pharmacological inhibition of phospholipase D protects mice from occlusive thrombus formation and ischemic stroke--brief report.	PLD1 PLD2	7.38e-06	2	95	2	23868933
Pubmed	Genomic analysis of murine phospholipase D1 and comparison to phospholipase D2 reveals an unusual difference in gene size.	PLD1 PLD2	7.38e-06	2	95	2	9813240
Pubmed	Transcriptional repression of cyclin-dependent kinase inhibitor p21 gene by phospholipase D1 and D2.	PLD1 PLD2	7.38e-06	2	95	2	12782287
Pubmed	Mono- and Poly-unsaturated Phosphatidic Acid Regulate Distinct Steps of Regulated Exocytosis in Neuroendocrine Cells.	PLD1 PLD2	7.38e-06	2	95	2	32814056
Pubmed	Elevated FBXW10 drives hepatocellular carcinoma tumorigenesis via AR-VRK2 phosphorylation-dependent GAPDH ubiquitination in male transgenic mice.	FBXW10B FBXW10	7.38e-06	2	95	2	37450367
Pubmed	Phospholipase D isoforms differentially regulate leukocyte responses to acute lung injury.	PLD1 PLD2	7.38e-06	2	95	2	29437245
Pubmed	Cloning and initial characterization of a human phospholipase D2 (hPLD2). ADP-ribosylation factor regulates hPLD2.	PLD1 PLD2	7.38e-06	2	95	2	9582313
Pubmed	Functional analysis of mammalian phospholipase D enzymes.	PLD1 PLD2	7.38e-06	2	95	2	30369483
Pubmed	Phagocyte cell migration is mediated by phospholipases PLD1 and PLD2.	PLD1 PLD2	7.38e-06	2	95	2	16873675
Pubmed	PLD1 promotes reactive oxygen species production in vascular smooth muscle cells and injury-induced neointima formation.	PLD1 PLD2	7.38e-06	2	95	2	34610470
Pubmed	Differential regulation of apoptosis by caspase-mediated cleavage of phospholipase D isozymes.	PLD1 PLD2	7.38e-06	2	95	2	18694819
Pubmed	Structure and regulation of human phospholipase D.	PLD1 PLD2	7.38e-06	2	95	2	33495125
Pubmed	Generation of choline for acetylcholine synthesis by phospholipase D isoforms.	PLD1 PLD2	7.38e-06	2	95	2	11734063
Pubmed	PLD1 and PLD2 differentially regulate the balance of macrophage polarization in inflammation and tissue injury.	PLD1 PLD2	7.38e-06	2	95	2	33368247
Pubmed	Phospholipases D1 and D2 Suppress Appetite and Protect against Overweight.	PLD1 PLD2	7.38e-06	2	95	2	27299737
Pubmed	The phospholipase D pathway mediates the inflammatory response of the retinal pigment epithelium.	PLD1 PLD2	7.38e-06	2	95	2	25172550
Pubmed	Deficiencies of the lipid-signaling enzymes phospholipase D1 and D2 alter cytoskeletal organization, macrophage phagocytosis, and cytokine-stimulated neutrophil recruitment.	PLD1 PLD2	7.38e-06	2	95	2	23383154
Pubmed	Characterization of human PLD2 and the analysis of PLD isoform splice variants.	PLD1 PLD2	7.38e-06	2	95	2	9761774
Pubmed	The molecular basis of leukocyte adhesion involving phosphatidic acid and phospholipase D.	PLD1 PLD2	7.38e-06	2	95	2	25187519
Pubmed	Phospholipase D in TCR-Mediated Signaling and T Cell Activation.	PLD1 PLD2	7.38e-06	2	95	2	29386256
Pubmed	Phospholipase D1 is a regulator of platelet-mediated inflammation.	PLD1 PLD2	7.38e-06	2	95	2	28711718
Pubmed	Expression of MARCKS effector domain mutants alters phospholipase D activity and cytoskeletal morphology of SK-N-MC neuroblastoma cells.	PLD1 PLD2	7.38e-06	2	95	2	16341931
Pubmed	Increased phospholipase D activity contributes to tumorigenesis in prostate cancer cell models.	PLD1 PLD2	7.38e-06	2	95	2	32661773
Pubmed	Phospholipase D is involved in the formation of Golgi associated clathrin coated vesicles in human parotid duct cells.	PLD1 PLD2	7.38e-06	2	95	2	24618697
Pubmed	Phospholipase D in cell proliferation and cancer.	PLD1 PLD2	7.38e-06	2	95	2	14517341
Pubmed	Phospholipase D is essential for keratocyte-like migration of NBT-II cells.	PLD1 PLD2	7.38e-06	2	95	2	18344600
Pubmed	Positive feedback regulation between phospholipase D and Wnt signaling promotes Wnt-driven anchorage-independent growth of colorectal cancer cells.	PLD1 PLD2	7.38e-06	2	95	2	20711340
Pubmed	Importance of PLD2 in an IL-23 driven psoriasiform dermatitis model and potential link to human psoriasis.	PLD1 PLD2	7.38e-06	2	95	2	37455419
Pubmed	Phospholipase D1 and D2 Synergistically Regulate Thrombus Formation.	PLD1 PLD2	7.38e-06	2	95	2	32971863
Pubmed	Role of phospholipases D1 and 2 in astroglial proliferation: effects of specific inhibitors and genetic deletion.	PLD1 PLD2	7.38e-06	2	95	2	25967349
Pubmed	Involvement of Phospholipase D 1 and 2 in the subcellular localization and activity of formyl-peptide-receptors in the human colonic cell line HT29.	PLD1 PLD2	7.38e-06	2	95	2	19707939
Pubmed	Key roles for the lipid signaling enzyme phospholipase d1 in the tumor microenvironment during tumor angiogenesis and metastasis.	PLD1 PLD2	7.38e-06	2	95	2	23131846
Pubmed	Phospholipase D: A new mediator during high phosphate-induced vascular calcification associated with chronic kidney disease.	PLD1 PLD2	7.38e-06	2	95	2	30207376
Pubmed	Redundant functions of phospholipases D1 and D2 in platelet α-granule release.	PLD1 PLD2	7.38e-06	2	95	2	22974101
Pubmed	Evidence for opposing selective forces operating on human-specific duplicated TCAF genes in Neanderthals and humans.	TCAF2 TCAF1	7.38e-06	2	95	2	34433829
Pubmed	Increased expression of two phospholipase D isoforms during experimentally induced hippocampal mossy fiber outgrowth.	PLD1 PLD2	7.38e-06	2	95	2	14999815
Pubmed	Phospholipase D is a target for inhibition of astroglial proliferation by ethanol.	PLD1 PLD2	7.38e-06	2	95	2	24262632
Pubmed	Enzymatic Activity Is Not Required for Phospholipase D Mediated TNF-α Regulation and Myocardial Healing.	PLD1 PLD2	7.38e-06	2	95	2	30555342
Pubmed	FBXW10 promotes hepatocarcinogenesis in male patients and mice.	FBXW10B FBXW10	7.38e-06	2	95	2	31400758
Pubmed	Role of phospholipase D in bleomycin-induced mitochondrial reactive oxygen species generation, mitochondrial DNA damage, and pulmonary fibrosis.	PLD1 PLD2	7.38e-06	2	95	2	31090437
Pubmed	The influence of polyunsaturated fatty acids on the phospholipase D isoforms trafficking and activity in mast cells.	PLD1 PLD2	7.38e-06	2	95	2	23698760
Pubmed	Phosphatidic acid, phospholipase D and tumorigenesis.	PLD1 PLD2	7.38e-06	2	95	2	24103483
Pubmed	Phospholipase D prevents apoptosis in v-Src-transformed rat fibroblasts and MDA-MB-231 breast cancer cells.	PLD1 PLD2	7.38e-06	2	95	2	12615079
Pubmed	Phospholipase D activates HIF-1-VEGF pathway via phosphatidic acid.	PLD1 PLD2	7.38e-06	2	95	2	25523098
Pubmed	Exosome Secretion and Epithelial-Mesenchymal Transition in Ovarian Cancer Are Regulated by Phospholipase D.	PLD1 PLD2	7.38e-06	2	95	2	36362078
Pubmed	Phospholipase D messenger RNA expression and clinical role in high-grade serous carcinoma.	PLD1 PLD2	7.38e-06	2	95	2	28087476
Pubmed	Impaired brain development and reduced cognitive function in phospholipase D-deficient mice.	PLD1 PLD2	7.38e-06	2	95	2	24813107
Pubmed	Expression of phospholipase D isozymes in mouse lungs during postnatal development.	PLD1 PLD2	7.38e-06	2	95	2	19652486
Pubmed	Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization.	PLD1 PLD2	7.38e-06	2	95	2	9395408
Pubmed	Platelet derived growth factor increases phospholipase D1 but not phospholipase D2 expression via NFkappaB signaling pathway and enhances invasion of breast cancer cells.	PLD1 PLD2	7.38e-06	2	95	2	20188462
Pubmed	Differential expression of phospholipases D1 and D2 in mouse tissues.	PLD1 PLD2	7.38e-06	2	95	2	17085061
Pubmed	Organization and alternative splicing of the murine phospholipase D2 gene.	PLD1 PLD2	7.38e-06	2	95	2	9560313
Pubmed	Phospholipase D in human platelets: presence of isoenzymes and participation of autocrine stimulation during thrombin activation.	PLD1 PLD2	7.38e-06	2	95	2	18432522
Pubmed	Phospholipase D1 Ablation Disrupts Mouse Longitudinal Hippocampal Axis Organization and Functioning.	PLD1 PLD2	7.38e-06	2	95	2	32209478
Pubmed	Phospholipase D and cancer metastasis: A focus on exosomes.	PLD1 PLD2	7.38e-06	2	95	2	36272918
Pubmed	Cross-talk between phospholipase D and MAP kinases activities.	PLD1 PLD2	7.38e-06	2	95	2	19896495
Pubmed	Phospholipase D2 localizes to the plasma membrane and regulates angiotensin II receptor endocytosis.	AGTR1 PLD1 PLD2	1.31e-05	17	95	3	14718562
Pubmed	Up-regulation of cyclooxygenase-2 by cobalt chloride-induced hypoxia is mediated by phospholipase D isozymes in human astroglioma cells.	PLD1 PLD2	2.21e-05	3	95	2	17640750
Pubmed	Involvement of phospholipase D in regulating expression of anti-microbial peptide human beta-defensin-2.	PLD1 PLD2	2.21e-05	3	95	2	17986621
Pubmed	Molecular mechanisms of N-formyl-methionyl-leucyl-phenylalanine-induced superoxide generation and degranulation in mouse neutrophils: phospholipase D is dispensable.	PLD1 PLD2	2.21e-05	3	95	2	23109426
Pubmed	Differential Roles of Phospholipase D Proteins in FcεRI-Mediated Signaling and Mast Cell Function.	PLD1 PLD2	2.21e-05	3	95	2	26392467
Pubmed	bcl-2 transgene expression inhibits apoptosis in the germinal center and reveals differences in the selection of memory B cells and bone marrow antibody-forming cells.	MRGPRX3 MRGPRX4	2.21e-05	3	95	2	10662793
Pubmed	Involvement of phospholipases D1 and D2 in sphingosine 1-phosphate-induced ERK (extracellular-signal-regulated kinase) activation and interleukin-8 secretion in human bronchial epithelial cells.	PLD1 PLD2	2.21e-05	3	95	2	12149127
Pubmed	Activation of mas-related G-protein-coupled receptors by the house dust mite cysteine protease Der p1 provides a new mechanism linking allergy and inflammation.	MRGPRX3 MRGPRX4	2.21e-05	3	95	2	28768771
Pubmed	The inhibition of high-voltage-activated calcium current by activation of MrgC11 involves phospholipase C-dependent mechanisms.	MRGPRX3 MRGPRX4	2.21e-05	3	95	2	26022362
Pubmed	Investigating the role of MRGPRC11 and capsaicin-sensitive afferent nerves in the anti-influenza effects exerted by SLIGRL-amide in murine airways.	MRGPRX3 MRGPRX4	2.21e-05	3	95	2	27215903
Pubmed	Phospholipase D confers rapamycin resistance in human breast cancer cells.	PLD1 PLD2	2.21e-05	3	95	2	12813467
Pubmed	Phospholipase D isozymes mediate epigallocatechin gallate-induced cyclooxygenase-2 expression in astrocyte cells.	PLD1 PLD2	2.21e-05	3	95	2	15210717
Pubmed	Interaction of the type Ialpha PIPkinase with phospholipase D: a role for the local generation of phosphatidylinositol 4, 5-bisphosphate in the regulation of PLD2 activity.	PLD1 PLD2	2.21e-05	3	95	2	11032811
Pubmed	Agonists of the MAS-related gene (Mrgs) orphan receptors as novel mediators of mast cell-sensory nerve interactions.	MRGPRX3 MRGPRX4	2.21e-05	3	95	2	18250432
Pubmed	Mas-related G protein-coupled receptor C11 (Mrgprc11) induces visceral hypersensitivity in the mouse colon: A novel target in gut nociception?	MRGPRX3 MRGPRX4	2.21e-05	3	95	2	31119828
Pubmed	Targeting phospholipase D1 attenuates intestinal tumorigenesis by controlling β-catenin signaling in cancer-initiating cells.	PLD1 PLD2	2.21e-05	3	95	2	26122663
Pubmed	Proenkephalin A gene products activate a new family of sensory neuron--specific GPCRs.	MRGPRX3 MRGPRX4	2.21e-05	3	95	2	11850634
Pubmed	Regulation of Phospholipase D by Arf6 during FcγR-Mediated Phagocytosis.	PLD1 PLD2	2.21e-05	3	95	2	30944160
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	KLHL3 FBXW10B SEMA4B FBXW10 KLHL1 APC2 USP24 DNAH2 SCAMP3 B3GNT3	3.17e-05	730	95	10	34857952
Pubmed	Munc-18-1 inhibits phospholipase D activity by direct interaction in an epidermal growth factor-reversible manner.	PLD1 PLD2	4.41e-05	4	95	2	14744865
Pubmed	Oxidized LDL phagocytosis during foam cell formation in atherosclerotic plaques relies on a PLD2-CD36 functional interdependence.	PLD1 PLD2	4.41e-05	4	95	2	29656494
Pubmed	The phox homology domain of phospholipase D activates dynamin GTPase activity and accelerates EGFR endocytosis.	PLD1 PLD2	4.41e-05	4	95	2	16622417
Pubmed	Overlap of direct and indirect alloreactive T-cell repertoires when MHC polymorphism is limited to the peptide binding groove.	MRGPRX3 MRGPRX4	4.41e-05	4	95	2	11821156
Pubmed	Cloning and functional expression of a novel Gi protein-coupled receptor for adenine from mouse brain.	MRGPRX3 MRGPRX4	4.41e-05	4	95	2	17975009
Pubmed	Actin directly interacts with phospholipase D, inhibiting its activity.	PLD1 PLD2	4.41e-05	4	95	2	11373276
Pubmed	Regulation of phospholipase D activity and phosphatidic acid production after purinergic (P2Y6) receptor stimulation.	PLD1 PLD2	4.41e-05	4	95	2	23723068
Pubmed	Human sensory neuron-specific Mas-related G protein-coupled receptors-X1 sensitize and directly activate transient receptor potential cation channel V1 via distinct signaling pathways.	MRGPRX3 MRGPRX4	4.41e-05	4	95	2	23074220
Pubmed	Phosphatidic acid-dependent recruitment and function of the Rac activator DOCK1 during dorsal ruffle formation.	PLD1 PLD2	4.41e-05	4	95	2	23362269
Pubmed	Characterization of new G protein-coupled adenine receptors in mouse and hamster.	MRGPRX3 MRGPRX4	4.41e-05	4	95	2	23608776
Pubmed	The distinct roles of two GPCRs, MrgprC11 and PAR2, in itch and hyperalgesia.	MRGPRX3 MRGPRX4	4.41e-05	4	95	2	21775281
Pubmed	Inhibition of phospholipase D by amphiphysins.	PLD1 PLD2	4.41e-05	4	95	2	10764771
Pubmed	Voltage-gated potassium channels involved in regulation of physiological function in MrgprA3-specific itch neurons.	MRGPRX3 MRGPRX4	4.41e-05	4	95	2	26874069
Pubmed	Tick peptides evoke itch by activating MrgprC11/MRGPRX1 to sensitize TRPV1 in pruriceptors.	MRGPRX3 MRGPRX4	4.41e-05	4	95	2	33358893
Pubmed	MrgprA3 shows sensitization to chloroquine in an acetone-ether-water mice model.	MRGPRX3 MRGPRX4	4.41e-05	4	95	2	29064954
Pubmed	USP48 alleviates bone cancer pain and regulates MrgC stabilization in spinal cord neurons of male mice.	MRGPRX3 MRGPRX4	4.41e-05	4	95	2	36864656
Pubmed	Class III PI-3-kinase activates phospholipase D in an amino acid-sensing mTORC1 pathway.	PLD1 PLD2	4.41e-05	4	95	2	22024166
Interaction	CXCR4 interactions	PDS5B NCAPD3 TMEM201 NAA25 WDR11 USP24 PLD1 PLD2 FANCA	1.42e-06	255	86	9	int:CXCR4
Interaction	GPR182 interactions	PDS5B NCAPD3 TMEM201 URB1 TCAF1 THADA USP24 SCAMP3 PLD2 UBE3C FANCA	3.67e-06	455	86	11	int:GPR182
Interaction	HCST interactions	PDS5B TCAF2 THADA RETREG2 USP24 UBE3C FANCA	2.77e-05	205	86	7	int:HCST
Interaction	GPR17 interactions	PDS5B URB1 NAA25 THADA RETREG2 USP24 UBR3 FANCA	2.82e-05	283	86	8	int:GPR17
Interaction	LYPD3 interactions	PDS5B THADA USP24 SCAMP3 TMEM214 TEX14	3.13e-05	141	86	6	int:LYPD3
Interaction	C19orf38 interactions	PDS5B NCAPD3 THADA USP24 UBE3C	3.34e-05	86	86	5	int:C19orf38
Interaction	LMBR1L interactions	CYC1 PDS5B NCAPD3 TMEM201 URB1 TCAF1 NAA25 THADA IARS1 USP24 DNAH2 SCAMP3 TMEM214 FANCA	4.44e-05	946	86	14	int:LMBR1L
Interaction	FBXW10B interactions	FBXW10B FBXW10	5.38e-05	3	86	2	int:FBXW10B
Cytoband	7q35	TCAF2 OR2F2 TCAF1 OR2F1	5.41e-06	55	95	4	7q35
Cytoband	Ensembl 112 genes in cytogenetic band chr7q35	TCAF2 OR2F2 TCAF1 OR2F1	1.12e-05	66	95	4	chr7q35
Cytoband	17p12	FBXW10B FBXW10 DNAH9	1.48e-04	49	95	3	17p12
Cytoband	Ensembl 112 genes in cytogenetic band chr11p15	OR52B4 PNPLA2 OR51M1 MRGPRX3 MRGPRX4 OR52M1 OR2AG1	1.77e-04	564	95	7	chr11p15
Cytoband	11p15.4	OR52B4 OR51M1 OR52M1 OR2AG1	8.16e-04	200	95	4	11p15.4
Cytoband	17p13.1	ZBTB4 DNAH2 PLD2	1.93e-03	118	95	3	17p13.1
GeneFamily	Olfactory receptors, family 2	OR2C1 OR2F2 OR2F1 OR2B6 OR2AJ1 OR2AG1	5.82e-06	113	72	6	149
GeneFamily	Kelch like\|BTB domain containing	KLHL11 KLHL3 KLHL2 KLHL1	2.31e-05	42	72	4	617
GeneFamily	Basic leucine zipper proteins\|BTB domain containing	KLHL11 KLHL3 KLHL2 KLHL1 ZBTB4	1.95e-04	134	72	5	861
GeneFamily	G protein-coupled receptors, Class A orphans	GPR26 GPR32 MRGPRX3 MRGPRX4	2.64e-04	78	72	4	262
GeneFamily	WD repeat domain containing\|F-box and WD repeat domain containing	FBXW10B FBXW10	8.40e-04	11	72	2	559
GeneFamily	Dyneins, axonemal	DNAH2 DNAH9	2.05e-03	17	72	2	536
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NLRP12 KLHL1 DNAH2 KCNN1 SLC13A3 CSMD3 DNAH9	7.18e-08	167	95	7	3edb0570e583bb527165bcd8a4c25a042054043b
ToppCell	facs-Heart-Unknown-3m-Endothelial-endothelial_cell_of_coronary_artery\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KLHL3 NLRP12 GPR26 C8B DNAH9	1.30e-05	141	95	5	4aa4b3476dc5abefbd348353cfe711cd5fe3d52f
ToppCell	facs-Heart-Unknown-3m-Endothelial-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KLHL3 NLRP12 GPR26 C8B DNAH9	1.30e-05	141	95	5	e40c6f1b7fbaa46b3eaa55f1b37ef360b04370a8
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_bronchial_vessel-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	KLHL3 ADCY4 MXRA5 CDH20 SPDYE6	1.44e-05	144	95	5	748f4efc59f7afbce6c497524f36d852b8b1d637
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_bronchial_vessel\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	KLHL3 ADCY4 CDH20 KIF26A SPDYE6	1.54e-05	146	95	5	df865558d1843f3857ebd1529cebc540d3554c59
ToppCell	E18.5-Immune-Immune_Myeloid-DC-cDC1-cDC1_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	USP49 ADCY4 NAA25 THADA CYB561D1	2.54e-05	162	95	5	388670cf3acef17df971c0d8ae3ce14398945192
ToppCell	E18.5-Immune-Immune_Myeloid-DC-cDC1\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	USP49 ADCY4 NAA25 THADA CYB561D1	2.54e-05	162	95	5	9333d923225df7bfdf6b3a4c32816751315aec50
Disease	developmental cardiac valvular defect (implicated_via_orthology)	PLD1 PLD2	8.79e-06	2	88	2	DOID:0080633 (implicated_via_orthology)
Disease	complex cortical dysplasia with other brain malformations (is_implicated_in)	KIF26A APC2	5.26e-05	4	88	2	DOID:0090131 (is_implicated_in)
Disease	AP-4 complex subunit mu-1 measurement	NLRP12 C8B	8.74e-05	5	88	2	EFO_0801385
Disease	testis-expressed sequence 29 protein measurement	NLRP12 C8B	2.43e-04	8	88	2	EFO_0802125
Disease	stromal cell-derived factor 1 alpha measurement	THADA CDH20 MRPL13	2.90e-04	43	88	3	EFO_0008293
Disease	WNT1-inducible-signaling pathway protein 1 measurement	SEPSECS C8B	3.90e-04	10	88	2	EFO_0008321
Disease	hair colour measurement, hair morphology measurement	MRPL13 FANCA	5.69e-04	12	88	2	EFO_0007821, EFO_0007822
Disease	copine-1 measurement	NLRP12 TRPC4AP	1.16e-03	17	88	2	EFO_0008102
Disease	response to TNF antagonist, joint damage measurement	MRPL36 CSMD3	2.52e-03	25	88	2	EFO_0004653, EFO_0005413

Protein segments in the cluster

Peptide	Gene	Start	Entry
LVIMHQISRSYLPRK	CYB561D1	211	Q8N8Q1
RLMLRIYLIKVPAHA	CSMD3	3551	Q7Z407
LHRTLKEILRYLMDP	APOBEC3B	181	Q9UH17
RYLAIVHPMKSRLRR	AGTR1	126	P30556
LPIHLSKYILRMLDR	FBXW10	281	Q5XX13
LKEIYHPRMLLILQA	GPR32	286	O75388
LLLSILPAYLAREMK	ADCY4	226	Q8NFM4
MALLVPLVYTIKRHK	CYC1	296	P08574
LYYLLIRTMKPLPRH	ADGRG7	551	Q96K78
RVKMYNFLRSLPTLH	ADGRG7	756	Q96K78
ELLLRLLEHRYPVVM	ABHD16B	346	Q9H3Z7
LHKGLSRLRLPLEYM	PDS5B	926	Q9NTI5
PALMLLLKLHYCRSN	OR6C1	156	Q96RD1
MIPARLHRDYKGLVL	PCDHGA12	1	O60330
ATYHRLLDKVELMLP	MPC2	11	O95563
LPIHLSKYILRMLDR	FBXW10B	281	O95170
LLEINRMTHKLLSRY	CYFIP1	801	Q7L576
YLVMRAKRKLGRHLP	PNPLA2	376	Q96AD5
AVKLDRRLHTPMYIL	OR11H6	66	Q8NGC7
ILVSRLDTKLHTPMY	OR2B6	46	P58173
RYHLTPVRMAIIKKS	nan	1111	O00370
LRLYLLGRVMLLHSK	KCNN1	236	Q92952
ALRILYVMRLARHSL	KCNG4	341	Q8TDN1
YAIPMLQLLLHRKAT	DDX56	61	Q9NY93
PLSYRAKMRLRDAAL	GPR26	111	Q8NDV2
RLHTPMYYLLSLLAL	OR51M1	66	Q9H341
ILTKRSLHEPMYLFL	OR52B4	51	Q8NGK2
ICKPLHYSTIMNRRL	OR4K1	126	Q8NGD4
MNLKPHRSREYLRLS	KIF20B	191	Q96Q89
AKHVPYRDHRLTMLL	KIF26A	671	Q9ULI4
SRKMPLTRLYVTILL	MRGPRX3	206	Q96LB0
LRRVLGKYMLPAHST	OR2AG1	301	Q9H205
VLLIRLDSRLHTPMY	OR2F1	46	Q13607
VLLIRLDSRLHTPMY	OR2F2	46	O95006
ILLSRLEARLHTPMY	OR2C1	46	O95371
HYTVIMPKRLCLALI	OR8H3	131	Q8N146
HKMTRDPLNLALRRY	APC2	451	O95996
LLRLSQMKPTYLTRH	KLHL11	291	Q9NVR0
VLLILSMRRHRKQPY	CDH20	636	Q9HBT6
THPLLTSLYRRLFVM	FANCA	351	O15360
LMYKRILLRLPSSVL	FANCA	1076	O15360
MALVHKLLRGTYFLR	NDUFAF1	1	Q9Y375
PKRLLLQRLYSMDLR	CBX7	76	O95931
HMLSLPHLRSRQLLY	AGBL2	136	Q5U5Z8
MKYLRHRRPNATLIL	B3GNT3	1	Q9Y2A9
MYLRRAVSKTLALPL	MGARP	1	Q8TDB4
EAMKYHLLPLDQRLL	KLHL3	271	Q9UH77
LRSLHKTYQIMKRRP	DNAH9	2161	Q9NYC9
KMLLELRRHNYVTPT	DNAH2	2966	Q9P225
AELAIRLRVHPLYLM	SLC13A3	496	Q8WWT9
VLGIVMLKRIHSLYR	SCAMP3	291	O14828
LKPRSLMLHYEFLQR	C8B	306	P07358
TSLYLRKMPRLTTLE	LRRN4	231	Q8WUT4
ILLIRSDSRLHTPMY	OR2AJ1	46	Q8NGZ0
HYAKIMSLRLCRLLV	OR1M1	131	Q8NGA1
LPLMIRLRLPLYKTH	OR52M1	161	Q8NGK5
IRKMVNPLLYLSRHT	MRPL36	6	Q9P0J6
MAGLKRRVPLHSLRY	TRMT2B	1	Q96GJ1
RPVVEKLLLMSYRLS	THADA	946	Q6YHU6
KLRHPYLLQLMAVCL	TEX14	301	Q8IWB6
PLYLRLLQRMEHSKK	TRPC4AP	706	Q8TEL6
PAYMSVHRLLRKLLS	TCAF1	456	Q9Y4C2
PAYISLHRLLRKMLR	TCAF2	456	A6NFQ2
SEYTKRTLMRLHPNI	PLD1	431	Q13393
HELIQRMYTRLEPLL	RETREG2	226	Q8NC44
LPVLFLLYRHRNSMK	SEMA4B	731	Q9NPR2
KDTLSIHYLMLPRVR	IARS1	796	P41252
SRKMPLTRLYVTILL	MRGPRX4	206	Q96LA9
YVLIVLMKHLRPTLA	URB1	1921	O60287
KIPALRELMHYLREV	NCAPD3	1216	P42695
RLKLLPYVGLLQHMD	SLITRK5	211	O94991
NLMLVTFKSPHIRRL	TMPRSS7	336	Q7RTY8
LAPMRLYTLSKRHFV	TMEM181	141	Q9P2C4
IPLLRKHRFQLYRSM	SPDYE6	331	P0CI01
SLDLDLRALKMIHPY	REXO5	311	Q96IC2
TYLDRLLLMHPNLTK	TMEM214	296	Q6NUQ4
SMFEKLLPRHLEIIY	PYGB	391	P11216
MIYRLPQVLRLHLKR	USP49	541	Q70CQ1
TLKLYRLLPMRAAKR	ZBTB4	411	Q9P1Z0
LLYRIARRMKPTHTM	TMEM201	31	Q5SNT2
RRLRKGYTPLMETHL	DCT	496	P40126
LAIYGMLPKNLHRRT	MRPL13	106	Q9BYD1
LRLDILLRMLKSPHF	USP24	386	Q9UPU5
RTSLHPSYKGLMRLL	UBR3	906	Q6ZT12
MSLTLCFLTLRHKRP	SEPSECS	146	Q9HD40
KRNHMLLLYPREILI	WDR11	256	Q9BZH6
RHKVLMSLLPLARFA	PLD2	116	O14939
ILPRMISHSELRKLF	PSPHP1	21	O15172
AIPAYHLRDLIKSML	UHMK1	271	Q8TAS1
KRYILRFPALETLML	XRRA1	221	Q6P2D8
KMRGSHLRLLPYLVA	TSR3	136	Q9UJK0
HRMMVPKVRLLYSLA	UBE3C	436	Q15386
LEAMKYHLLPERRTL	KLHL1	431	Q9NR64
LMEHVRLPLLPREYL	KLHL2	241	O95198
RYTRLLLVKEHSNPM	NLRP12	156	P59046
IKYLGLMEHLRVRRA	MYO1H	616	Q8N1T3
LHRELMLSKDPRVSY	MXRA5	391	Q9NR99
TILYREMHRPELVTK	NAA25	86	Q14CX7