Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainNUT

NUTM2F NUTM2G

8.16e-055542IPR024310
DomainNUT_N

NUTM2F NUTM2G

8.16e-055542IPR024309
DomainNUT

NUTM2F NUTM2G

8.16e-055542PF12881
DomainIGv

PDCD1 OBSCN DSCAML1

1.33e-0375543SM00406
DomainPH

FGD2 OBSCN GAB1 OPHN1

4.31e-03229544PF00169
DomainPH

FGD2 OBSCN GAB1 OPHN1

8.48e-03278544SM00233
DomainPH_DOMAIN

FGD2 OBSCN GAB1 OPHN1

8.58e-03279544PS50003
DomainPH_domain

FGD2 OBSCN GAB1 OPHN1

8.69e-03280544IPR001849
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

SETX VPS72 INPPL1 BACH2 KDM2B C15orf39 CUL7 LZTS2 GAB1

4.64e-0758857938580884
Pubmed

Gab1 and Mapk Signaling Are Essential in the Hair Cycle and Hair Follicle Stem Cell Quiescence.

EGR2 GAB1

1.58e-05457226456821
Pubmed

Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.

PPP1R26 CTU2 COL12A1 VPS72 INPPL1 LZTS2 DSCAML1 MMACHC

1.60e-0568957836543142
Pubmed

Interactomes of Glycogen Synthase Kinase-3 Isoforms.

MIA3 PTPN12 INPPL1 LZTS2 GAB1

2.43e-0520957536779422
Pubmed

Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians.

BACH2 TNFAIP3 SEZ6L2

3.38e-053857323273568
Pubmed

TGF-β3-expressing CD4+CD25(-)LAG3+ regulatory T cells control humoral immune responses.

PDCD1 EGR2

5.51e-05757225695838
Pubmed

Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.

PPP1R26 THSD7B CUL7 DSCAML1

6.31e-0513057412421765
Pubmed

Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses.

INPPL1 GAB1

9.43e-05957210871282
Pubmed

Common variants near TARDBP and EGR2 are associated with susceptibility to Ewing sarcoma.

EGR2 EIF2AK4

9.43e-05957222327514
Pubmed

EGR1 and EGR2 involvement in vertebrate tendon differentiation.

COL12A1 EGR2

2.03e-041357221173153
Pubmed

Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.

MRPL44 OBSCN CUL7 SEZ6L2

4.26e-0421457422199357
Pubmed

Identification of early-responsive genes correlated to valproic acid-induced neural tube defects in mice.

EGR2 IER5

4.43e-041957215799026
Pubmed

Hereditary Ataxia Overview

FAT2 SETX OPHN1

4.73e-049257320301317
Pubmed

Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor.

PTPN12 INPPL1 GAB1

6.57e-0410357321706016
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

PRR14 SPATA31E1 EGR2 INPPL1 GAB1

6.97e-0443057535044719
Pubmed

Loss of Krox20 results in aortic valve regurgitation and impaired transcriptional activation of fibrillar collagen genes.

COL12A1 EGR2

7.12e-042457225344368
Pubmed

Large-scale cDNA transfection screening for genes related to cancer development and progression.

C15orf39 IER5 NSMCE4A

8.82e-0411457315498874
Pubmed

Mutations in Hcfc1 and Ronin result in an inborn error of cobalamin metabolism and ribosomopathy.

EGR2 MMACHC

1.04e-032957235013307
Pubmed

Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry.

INPPL1 GAB1

1.11e-033057212522270
Pubmed

Characterization of long cDNA clones from human adult spleen.

FGD2 SUDS3

1.35e-033357211214971
Pubmed

Proteotyping of knockout mouse strains reveals sex- and strain-specific signatures in blood plasma.

PTPN12 MMACHC

1.43e-033457234050187
CytobandEnsembl 112 genes in cytogenetic band chr9q22

SPATA31E1 NUTM2F ZNF367 NUTM2G

1.15e-04200574chr9q22
Cytoband9q22.32

NUTM2F ZNF367

5.21e-04275729q22.32
Cytoband15q15.1

EIF2AK4 ITPKA

1.58e-034757215q15.1
ToppCellsevere_COVID-19-NK_CD56bright|World / disease group, cell group and cell class (v2)

LDOC1 GAPDHS MMACHC NUTM2G

4.30e-05152574ab5a4e47b23d16018642d4c9c7f41b30205edf73
ToppCellLPS-IL1RA+antiTNF-Myeloid-Dendritic_cells|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PDCD1 FAT2 FGD2 PCSK1N

4.41e-05153574c81a88d3f707487c511020d3960a1c41e706c6a0
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L6_CT|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

COL12A1 OBSCN IER5 THSD7B

4.76e-05156574fe383ce3a0c37f7343d7026cb51260a04d4c2829
ToppCellsevere_COVID-19-NK_CD56bright|severe_COVID-19 / disease group, cell group and cell class (v2)

KDM2B LDOC1 GAPDHS NUTM2G

5.00e-05158574c2e8d96fc29aa2388b92b4fd81d2726e1f7a053f
ToppCelldroplet-Marrow-BM-30m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TICRR INPPL1 TIGD5 ENOX2

5.78e-05164574b77995958c938e10a526118f75d78cee72e0b207
ToppCellnormal_Lung-Fibroblasts-Myofibroblasts|Fibroblasts / Location, Cell class and cell subclass

COL12A1 EGR2 SEZ6L2 ITPKA

5.78e-051645749b4a6007abae992db871d9f6f731d5af724de30d
ToppCelldroplet-Lung-30m-Hematologic-myeloid-myeloid_dendritic_cell-proliferating_dendritic|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FGD2 ROR1 EIF2AK4 ITPKA

6.96e-05172574b043d4f81dced7fb3326043f68474123be47cc5d
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L6_IT-L6_IT_VISp_Penk_Fst|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

EGR2 ROR1 IER5 ITPKA

7.60e-05176574a1b9f8f199a028b3fa85de43fe96bc29f387bfd8
ToppCell3'-Distal_airway-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.3.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PPP1R26 SSC5D FGD2 TIGD5

7.60e-0517657476fdf211bce101e83a27d822cb399487bd107027
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_VIP_PRSS8|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

COL12A1 ROR1 PCSK1N THSD7B

9.22e-051855744c42bd3cd72f91f4d4ebb849069a03761a2cd662
ToppCellBAL-Control-Myeloid-MoAM-MoAM5|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CTU2 TNFAIP3 MMACHC OPHN1

9.61e-0518757459d28f4ee1d463ae20abb8d7e7399b504d80698a
ToppCellControl-Myeloid-MoAM5|Control / Disease group,lineage and cell class (2021.01.30)

CTU2 TNFAIP3 MMACHC OPHN1

9.61e-051875748769341be67382cea2a590d962f4def7c39de883
ToppCellBAL-Control-Myeloid-MoAM-MoAM5-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CTU2 TNFAIP3 MMACHC OPHN1

9.61e-0518757425adf648c05c21534b4913254e73d43fc5f64e06
ToppCellBAL-Control-Myeloid-MoAM-MoAM5|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

CTU2 TNFAIP3 MMACHC OPHN1

9.61e-051875743b0cfa9e5ea5e7d6dda689c328b9b5110b43ee1d
ToppCellBAL-Control-Myeloid-MoAM-MoAM5-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

CTU2 TNFAIP3 MMACHC OPHN1

9.61e-051875740d589de12108230ced5b60229564f4a181e2f172
ToppCellIPF-Myeloid-DC_Mature|Myeloid / Disease state, Lineage and Cell class

ROR1 KDM2B DSCAML1 GAB1

1.00e-0418957449e67d298d045f29136919b7d9971b6502b0efaa
ToppCellwk_20-22-Mesenchymal-Myofibro_&_SMC-Myofibro_2|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

SSC5D COL12A1 ROR1 PCSK1N

1.09e-041935742f203f6f0c2135acb046c9351a633c3b5b254a46
ToppCell3'-Broncho-tracheal-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SSC5D PCSK1N LDOC1 THSD7B

1.11e-0419457491205b22650e7ecdb72bb59348ce2530b76c532c
ToppCell3'-Broncho-tracheal-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SSC5D PCSK1N LDOC1 THSD7B

1.11e-041945746e12a7da35be4c0ecf998ef94b8989b89d74b200
ToppCell3'-Broncho-tracheal-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SSC5D PCSK1N LDOC1 THSD7B

1.11e-04194574c52f10140c66e8c0566421c3d535d5d92bf595e1
ToppCellfacs-Pancreas-Endocrine-18m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MIA3 KDM2B PCSK1N SEZ6L2

1.13e-04195574bd8e24dd598990204998d1dd853ba7a53dc0107e
ToppCell3'_v3-lymph-node_spleen-Lymphocytic_T_CD8-Tnaive/CM_CD8|lymph-node_spleen / Manually curated celltypes from each tissue

KLF13 BACH2 PCSK1N TNFAIP3

1.15e-04196574e7fd508cb9a8a5b3d1c0247dabf486c4434b5e94
ToppCellMatrixFB-Fibroblast-B_(Myofibroblast)|MatrixFB / shred on cell class and cell subclass (v4)

SSC5D COL12A1 BACH2 RHOU

1.15e-0419657438ea0eaf42f95c321ca23570d0d7752980cf00f8
ToppCell(5)_Fibroblasts-(5)_Fibroblast-B_(Myofibroblast)|(5)_Fibroblasts / Lung cell shreds - cell class (v4) and cell subclass (v4)

SSC5D COL12A1 PCSK1N SEZ6L2

1.20e-04198574196257c4420ac801ed9fbb444f11718adb7560ae
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW16-Neuronal|GW16 / Sample Type, Dataset, Time_group, and Cell type.

PCSK1N LDOC1 SEZ6L2 OPHN1

1.24e-0420057484e4565d28a02700bf7f6730d1b3a58744ca0aea
ToppCellNeuronal-Inhibitory-iA-iA_1(SST_PAX6)-PAX6-TSPAN12-L1-2|Neuronal / cells hierarchy compared to all cells using T-Statistic

COL12A1 ROR1 PCSK1N THSD7B

1.24e-04200574523d799eb315b33b77e02d5b7db63dad8450c4e1
ToppCellproximal-mesenchymal-Fibromyocyte-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SSC5D PCSK1N LDOC1 THSD7B

1.24e-0420057437d9f46f727a31e8e94e348e4ddd71a2125ba01a
ToppCellproximal-3-mesenchymal-Fibromyocyte|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SSC5D PCSK1N LDOC1 THSD7B

1.24e-04200574ed6fbe61a04d29b105054f7058abe7469314b304
ToppCellNeuronal-Inhibitory-iA-iA_1(SST_PAX6)-PAX6-TSPAN12|Neuronal / cells hierarchy compared to all cells using T-Statistic

COL12A1 ROR1 PCSK1N THSD7B

1.24e-04200574e5cef95e563a6e793ade190ce88c999bfa0af460
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW16-Neuronal-Cortical_neuron|GW16 / Sample Type, Dataset, Time_group, and Cell type.

PCSK1N LDOC1 SEZ6L2 OPHN1

1.24e-0420057419055194a5e0ea122f1b8fc62df44813f6843c95
ToppCellproximal-mesenchymal-Fibromyocyte|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SSC5D PCSK1N LDOC1 THSD7B

1.24e-0420057449658e1b530de0dad16d45a1112bdf5329bb800d
Drugbazedoxifene

COL12A1 EGR2 SEZ6L2 ZNF367

6.50e-0651544ctd:C447119
DiseaseAutistic Disorder

HTR3A EGR2 CUL7 SEZ6L2

1.25e-03261534C0004352
Diseasekeratinocyte carcinoma

VPS72 BACH2 RHOU

1.26e-03118533EFO_0010176
Diseaseeosinophil percentage of leukocytes

PDCD1 EGR2 BACH2 IER5 TNFAIP3 ITPKA

2.14e-03746536EFO_0007991
Diseaserespiratory system disease

BACH2 TNFAIP3 ITPKA

2.27e-03145533EFO_0000684
DiseaseEczema

FGD2 BACH2 TNFAIP3 ITPKA

2.33e-03310534HP_0000964
Diseaseejection fraction measurement

TNFAIP3 LZTS2

2.73e-0343532EFO_0005527
DiseaseMultiple Sclerosis

PDCD1 TNFAIP3

2.98e-0345532C0026769
DiseaseMultiple Sclerosis, Acute Fulminating

PDCD1 TNFAIP3

2.98e-0345532C0751324
DiseaseAgents acting on the renin-angiotensin system use measurement

TICRR MIA3 KDM2B ITPKA

3.08e-03335534EFO_0009931
DiseaseDiuretic use measurement

TICRR VPS72 KDM2B

3.50e-03169533EFO_0009928

Protein segments in the cluster

PeptideGeneStartEntry
PVPIKVCPRSPPLET

BACH2

501

Q9BYV9
LRPDACGPVKEPPEI

EIF2AK4

41

Q9P2K8
KSPRDRCSPPPPPRE

HTR3A

396

P46098
RKPFPCPLDTLRVPP

EGR2

246

P11161
DPPCRAATPQKPEPK

OPHN1

746

O60890
PETRVSCLPPEPPKT

FAM47C

191

Q5HY64
EPLCPAVPPRKAVPV

LZTS2

71

Q9BRK4
LRQVRPPSCPVPFPE

LDOC1

41

O95751
PKTPPRRPVPVADCE

GAB1

501

Q13480
RRPVPVADCEPPPVD

GAB1

506

Q13480
PPPATRERPPGCKTV

ENOX2

116

Q16206
FRPPPALCARPVKEP

PCSK1N

26

Q9UHG2
REKTPEPPVPCVPEQ

PDCD1

231

Q15116
KQRPVVCSVPPRLPP

FAT2

4136

Q9NYQ8
CEAPPPVVATPRPKG

CUL7

1106

Q14999
VPDLPPRKPHDCVPT

MMACHC

171

Q9Y4U1
VPPTSPGPPERERDC

ITPKA

91

P23677
CISKETPAPVVPPEP

OBSCN

5101

Q5VST9
RVISRPPPSVSPPKC

KDM2B

1021

Q8NHM5
PEPNCPAPRKVEVPG

CCN3

151

P48745
PPPTIPPARDVCKGA

COL12A1

2306

Q99715
FRKADGREPCPVVPP

DSCAML1

1911

Q8TD84
PECRPPESPGPREKT

FGD2

41

Q7Z6J4
KARTPCRLPPPAPEP

KLF13

91

Q9Y2Y9
PPTPRSPKAQRPVAC

ENDOV

256

Q8N8Q3
CPVTRAPPPPEPKAE

GAPDHS

21

O14556
PPPAPRPSREQKCVK

CTU2

16

Q2VPK5
TACLPPPRPQRPVTK

NUTM2D

391

Q5VT03
ACLPPPRPQRPAETK

NUTM2F

341

A1L443
ACLPPPRPQRPAETK

NUTM2G

341

Q5VZR2
DEPPAPPAVCPRKRC

IER5

206

Q5VY09
LRCPPPPVRRSEKPN

MRPL44

51

Q9H9J2
ECSPPLTVEPPVRPL

MIA3

1676

Q5JRA6
RAPPPPRPCLRKEVF

PRR14

371

Q9BWN1
DSPPPKPPRTRSCLV

PTPN12

331

Q05209
CPLSRLFEEPEKPPP

INPPL1

926

O15357
PAIVPPKKFRQCPEP

SETX

1266

Q7Z333
PSPRIIPPSPTCAEK

SLC9A5

746

Q14940
RIPPPAPRPSVECTG

SPATA31E1

21

Q6ZUB1
CPVPKPRVDRPRKVP

NSMCE4A

226

Q9NXX6
PARPEVLCRKEPAPP

PPP1R26

871

Q5T8A7
KEVPRNDTCPELPPP

SEZ6L2

636

Q6UXD5
PTPPVRVMACEPPAL

SSC5D

1476

A1L4H1
PIVIRDSPVPCTPPA

C15orf39

461

Q6ZRI6
PDRCEAPPVPPRRER

RHOU

11

Q7L0Q8
PPRVIQHCPPPKSRS

ROR1

841

Q01973
RLPPAPVSGEPPERC

ZNF503-AS2

146

A6NEH8
DTVPPPPPSKVGKRC

TICRR

1371

Q7Z2Z1
EPAPEDPPKQRCRAP

TNFAIP3

751

P21580
LPEPAPRPPDGTRCV

TMPRSS9

936

Q7Z410
RDERPPPAKLPCLSP

nan

271

Q8N9G6
RDERPPPAKLPCLSP

nan

271

A8MUA0
GRPPKVPVREVCPVT

VPS72

281

Q15906
SLCPVPPPPERKSCE

THSD7B

581

Q9C0I4
PPPPERKSCEIPCRM

THSD7B

586

Q9C0I4
PPPPVIFCHDSPKRV

ZNF367

16

Q7RTV3
DAPVRCRPEPLGPPE

TIGD5

376

Q53EQ6
PRPCPGPKRPVSLEL

PRR30

391

Q53SZ7
DPVPIPDKRRKPAPA

SUDS3

191

Q9H7L9
PHARPELPERPPCKV

PRR23C

241

Q6ZRP0
RPVPSLPDVCPKEPT

VPS54

31

Q9P1Q0