Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncalcium ion binding

THBS1 THBS2 LRP4 LRP1B COMP

7.33e-0874955GO:0005509
GeneOntologyMolecularFunctionextracellular matrix structural constituent

THBS1 THBS2 COMP

8.10e-0618853GO:0005201
GeneOntologyMolecularFunctionheparin binding

THBS1 THBS2 COMP

8.63e-0619253GO:0008201
GeneOntologyMolecularFunctionglycosaminoglycan binding

THBS1 THBS2 COMP

2.34e-0526853GO:0005539
GeneOntologyMolecularFunctionfibronectin binding

THBS1 COMP

3.51e-053852GO:0001968
GeneOntologyMolecularFunctionsulfur compound binding

THBS1 THBS2 COMP

4.09e-0532353GO:1901681
GeneOntologyMolecularFunctionproteoglycan binding

THBS1 COMP

6.36e-055152GO:0043394
GeneOntologyMolecularFunctioncollagen binding

THBS1 COMP

1.61e-048152GO:0005518
GeneOntologyMolecularFunctioncytokine binding

THBS1 COMP

6.05e-0415752GO:0019955
GeneOntologyMolecularFunctionintegrin binding

THBS1 COMP

7.51e-0417552GO:0005178
GeneOntologyMolecularFunctionprotease binding

THBS1 COMP

8.03e-0418152GO:0002020
GeneOntologyMolecularFunctionstructural molecule activity

THBS1 THBS2 COMP

8.28e-0489153GO:0005198
GeneOntologyMolecularFunctioncell adhesion molecule binding

THBS1 COMP

8.46e-0359952GO:0050839
GeneOntologyMolecularFunctionprotein homodimerization activity

THBS1 LRP4

1.53e-0281552GO:0042803
GeneOntologyMolecularFunctionlipid binding

THBS1 COMP

2.21e-0298852GO:0008289
GeneOntologyMolecularFunctionprotein dimerization activity

THBS1 LRP4

3.22e-02120552GO:0046983
GeneOntologyBiologicalProcessgrowth plate cartilage development

THBS1 COMP

1.90e-052952GO:0003417
GeneOntologyBiologicalProcessregulation of cell junction assembly

THBS1 THBS2 LRP4

3.26e-0530953GO:1901888
GeneOntologyBiologicalProcessendochondral bone growth

THBS1 COMP

3.47e-053952GO:0003416
GeneOntologyBiologicalProcessbone growth

THBS1 COMP

4.63e-054552GO:0098868
GeneOntologyBiologicalProcesscartilage development involved in endochondral bone morphogenesis

THBS1 COMP

5.06e-054752GO:0060351
GeneOntologyBiologicalProcessnegative regulation of hemostasis

THBS1 COMP

1.13e-047052GO:1900047
GeneOntologyBiologicalProcessendochondral bone morphogenesis

THBS1 COMP

1.44e-047952GO:0060350
GeneOntologyBiologicalProcessregulation of hemostasis

THBS1 COMP

1.99e-049352GO:1900046
GeneOntologyBiologicalProcesscell junction assembly

THBS1 THBS2 LRP4

2.00e-0456953GO:0034329
GeneOntologyBiologicalProcessbone morphogenesis

THBS1 COMP

3.54e-0412452GO:0060349
GeneOntologyBiologicalProcessregulation of ossification

LRP4 COMP

4.97e-0414752GO:0030278
GeneOntologyBiologicalProcessresponse to unfolded protein

THBS1 COMP

5.04e-0414852GO:0006986
GeneOntologyBiologicalProcessblood vessel morphogenesis

THBS1 THBS2 COMP

5.83e-0481753GO:0048514
GeneOntologyBiologicalProcessendocytosis

THBS1 LRP4 LRP1B

6.04e-0482753GO:0006897
GeneOntologyBiologicalProcessresponse to topologically incorrect protein

THBS1 COMP

6.34e-0416652GO:0035966
GeneOntologyBiologicalProcessnegative regulation of angiogenesis

THBS1 THBS2

7.04e-0417552GO:0016525
GeneOntologyBiologicalProcessnegative regulation of blood vessel morphogenesis

THBS1 THBS2

7.28e-0417852GO:2000181
GeneOntologyBiologicalProcessnegative regulation of vasculature development

THBS1 THBS2

7.44e-0418052GO:1901343
GeneOntologyBiologicalProcessdevelopmental growth

THBS1 LRP4 COMP

8.03e-0491153GO:0048589
GeneOntologyBiologicalProcessblood vessel development

THBS1 THBS2 COMP

8.51e-0492953GO:0001568
GeneOntologyBiologicalProcessregulation of synapse assembly

THBS2 LRP4

9.36e-0420252GO:0051963
GeneOntologyBiologicalProcessvasculature development

THBS1 THBS2 COMP

9.63e-0496953GO:0001944
GeneOntologyBiologicalProcesscell junction organization

THBS1 THBS2 LRP4

9.77e-0497453GO:0034330
GeneOntologyBiologicalProcesslimb development

LRP4 COMP

1.15e-0322452GO:0060173
GeneOntologyBiologicalProcessappendage development

LRP4 COMP

1.15e-0322452GO:0048736
GeneOntologyBiologicalProcessimport into cell

THBS1 LRP4 LRP1B

1.30e-03107453GO:0098657
GeneOntologyBiologicalProcesscartilage development

THBS1 COMP

1.35e-0324352GO:0051216
GeneOntologyBiologicalProcessregulation of anatomical structure morphogenesis

THBS1 THBS2 LRP4

1.36e-03109053GO:0022603
GeneOntologyBiologicalProcesstube morphogenesis

THBS1 THBS2 COMP

1.49e-03112553GO:0035239
GeneOntologyBiologicalProcessorgan growth

THBS1 COMP

1.50e-0325652GO:0035265
GeneOntologyBiologicalProcessblood coagulation

THBS1 COMP

1.54e-0326052GO:0007596
GeneOntologyBiologicalProcessbone development

THBS1 COMP

1.59e-0326452GO:0060348
GeneOntologyBiologicalProcesscoagulation

THBS1 COMP

1.61e-0326652GO:0050817
GeneOntologyBiologicalProcesshemostasis

THBS1 COMP

1.64e-0326852GO:0007599
GeneOntologyBiologicalProcessenzyme-linked receptor protein signaling pathway

THBS1 LRP4 COMP

1.74e-03118653GO:0007167
GeneOntologyBiologicalProcessskeletal system morphogenesis

THBS1 COMP

1.75e-0327752GO:0048705
GeneOntologyBiologicalProcessregulation of cellular component biogenesis

THBS1 THBS2 LRP4

1.75e-03118953GO:0044087
GeneOntologyBiologicalProcessprotein processing

THBS1 COMP

1.85e-0328552GO:0016485
GeneOntologyBiologicalProcessnegative regulation of developmental process

THBS1 THBS2 LRP4

1.89e-03122053GO:0051093
GeneOntologyBiologicalProcessgrowth

THBS1 LRP4 COMP

1.95e-03123553GO:0040007
GeneOntologyBiologicalProcessanimal organ morphogenesis

THBS1 LRP4 COMP

2.11e-03126953GO:0009887
GeneOntologyBiologicalProcesssynapse assembly

THBS2 LRP4

2.16e-0330852GO:0007416
GeneOntologyBiologicalProcessconnective tissue development

THBS1 COMP

2.67e-0334352GO:0061448
GeneOntologyBiologicalProcesstube development

THBS1 THBS2 COMP

2.82e-03140253GO:0035295
GeneOntologyBiologicalProcesscirculatory system development

THBS1 THBS2 COMP

3.06e-03144253GO:0072359
GeneOntologyBiologicalProcessskin development

LRP4 COMP

3.15e-0337352GO:0043588
GeneOntologyBiologicalProcessnegative regulation of multicellular organismal process

THBS1 THBS2 LRP4

3.35e-03148853GO:0051241
GeneOntologyBiologicalProcessregulation of synapse organization

THBS2 LRP4

3.38e-0338752GO:0050807
GeneOntologyBiologicalProcessregulation of synapse structure or activity

THBS2 LRP4

3.52e-0339552GO:0050803
GeneOntologyBiologicalProcessregulation of angiogenesis

THBS1 THBS2

3.97e-0342052GO:0045765
GeneOntologyBiologicalProcessregulation of vasculature development

THBS1 THBS2

4.16e-0343052GO:1901342
GeneOntologyBiologicalProcessregulation of body fluid levels

THBS1 COMP

4.39e-0344252GO:0050878
GeneOntologyBiologicalProcesstransforming growth factor beta receptor superfamily signaling pathway

THBS1 COMP

4.45e-0344552GO:0141091
GeneOntologyCellularComponentcollagen-containing extracellular matrix

THBS1 THBS2 COMP

1.56e-0453053GO:0062023
GeneOntologyCellularComponentplatelet alpha granule

THBS1 THBS2

1.94e-049352GO:0031091
GeneOntologyCellularComponentextracellular matrix

THBS1 THBS2 COMP

2.93e-0465653GO:0031012
GeneOntologyCellularComponentexternal encapsulating structure

THBS1 THBS2 COMP

2.96e-0465853GO:0030312
HumanPhenoAbnormal carpal morphology

LRP4 COMP

3.16e-049122HP:0001191
HumanPhenoAbnormality of the musculature of the hand

LRP4 COMP

5.97e-0412522HP:0001421
HumanPhenoAbnormality of the ulna

LRP4 COMP

9.68e-0415922HP:0002997
HumanPhenoAbnormal morphology of ulna

LRP4 COMP

9.68e-0415922HP:0040071
HumanPhenoAbnormality of the wrist

LRP4 COMP

1.08e-0316822HP:0003019
HumanPhenoAbnormal distal phalanx morphology of finger

LRP4 COMP

1.16e-0317422HP:0009832
HumanPhenoAbnormal forearm bone morphology

LRP4 COMP

1.27e-0318222HP:0040073
HumanPhenoAbnormal morphology of the radius

LRP4 COMP

1.81e-0321722HP:0002818
HumanPhenoAbnormality of the metacarpal bones

LRP4 COMP

1.99e-0322822HP:0001163
HumanPhenoAbnormal metacarpal morphology

LRP4 COMP

1.99e-0322822HP:0005916
HumanPhenoAbnormal forearm bone morphology

LRP4 COMP

2.14e-0323622HP:0040072
HumanPhenoAbnormal forearm morphology

LRP4 COMP

2.19e-0323922HP:0002973
HumanPhenoAbnormal shoulder morphology

LRP4 COMP

2.32e-0324622HP:0003043
HumanPhenoShort long bone

LRP4 COMP

2.97e-0327822HP:0003026
HumanPhenoAbnormality of the elbow

LRP4 COMP

3.05e-0328222HP:0009811
HumanPhenoAbnormality of the musculature of the upper limbs

LRP4 COMP

3.08e-0328322HP:0001446
HumanPhenoBowing of the long bones

LRP4 COMP

3.84e-0331622HP:0006487
HumanPhenoAnomaly of the limb diaphyses

LRP4 COMP

3.98e-0332222HP:0006504
HumanPhenoShort finger

LRP4 COMP

4.06e-0332522HP:0009381
HumanPhenoAbnormal rib morphology

LRP4 COMP

4.34e-0333622HP:0000772
HumanPhenoMyopathy

LRP4 COMP

4.47e-0334122HP:0003198
HumanPhenoAbnormal diaphysis morphology

LRP4 COMP

4.52e-0334322HP:0000940
HumanPhenoAbnormal form of the vertebral bodies

LRP4 COMP

4.65e-0334822HP:0003312
HumanPhenoAplasia/Hypoplasia of fingers

LRP4 COMP

5.15e-0336622HP:0006265
HumanPhenoBrachydactyly (hand)

LRP4 COMP

7.11e-0343022HP:0100667
HumanPhenoFunctional motor deficit

LRP4 COMP

7.31e-0343622HP:0004302
HumanPhenoAbnormal morphology of bones of the upper limbs

LRP4 COMP

7.31e-0343622HP:0040065
HumanPhenoLimb undergrowth

LRP4 COMP

7.58e-0344422HP:0009826
HumanPhenoAbnormal rib cage morphology

LRP4 COMP

7.62e-0344522HP:0001547
HumanPhenoAplasia/hypoplasia involving bones of the lower limbs

LRP4 COMP

8.64e-0347422HP:0006493
HumanPhenoAbnormal vertebral morphology

LRP4 COMP

8.97e-0348322HP:0003468
MousePhenoabnormal tendon morphology

THBS2 COMP

4.74e-053152MP:0005503
MousePhenoincreased compact bone thickness

THBS2 LRP4

8.35e-054152MP:0004148
MousePhenoabnormal spine curvature

THBS1 THBS2 LRP4

1.13e-0431853MP:0004174
MousePhenolimbs/digits/tail phenotype

THBS1 THBS2 LRP4 COMP

3.03e-04125854MP:0005371
MousePhenoabnormal chondrocyte morphology

LRP4 COMP

3.44e-048352MP:0000166
MousePhenoabnormal hindlimb morphology

THBS1 LRP4 COMP

6.54e-0457653MP:0000556
MousePhenoabnormal compact bone thickness

THBS2 LRP4

7.43e-0412252MP:0000134
MousePhenoabnormal response to injury

THBS1 THBS2 COMP

7.63e-0460753MP:0005164
MousePhenoabnormal compact bone morphology

THBS2 LRP4

1.47e-0317252MP:0003797
MousePhenoabnormal vertebral column morphology

THBS1 THBS2 LRP4

1.63e-0378753MP:0004703
MousePhenoabnormal wound healing

THBS2 COMP

1.85e-0319352MP:0005023
MousePhenoabnormal exocrine gland morphology

THBS1 THBS2 LRP4

2.06e-0385353MP:0013558
MousePhenoabnormal femur morphology

LRP4 COMP

2.26e-0321452MP:0000559
MousePhenoabnormal hindlimb stylopod morphology

LRP4 COMP

2.28e-0321552MP:0003856
MousePhenodecreased apoptosis

THBS1 THBS2

2.37e-0321952MP:0006043
MousePhenodecreased cell death

THBS1 THBS2

2.45e-0322352MP:0012555
MousePhenokyphosis

THBS1 THBS2

2.59e-0322952MP:0000160
MousePhenoabnormal limb morphology

THBS1 LRP4 COMP

3.54e-03102853MP:0002109
MousePhenoabnormal skin physiology

THBS1 THBS2

4.06e-0328852MP:0005501
MousePhenoabnormal muscle morphology

THBS1 THBS2 COMP

4.37e-03110653MP:0002108
MousePhenoabnormal cartilage morphology

LRP4 COMP

5.49e-0333652MP:0000163
MousePhenoabnormal angiogenesis

THBS1 THBS2

6.70e-0337252MP:0000260
DomainEGF_CA

THBS1 THBS2 LRP4 LRP1B COMP

1.84e-128655PF07645
DomainEGF_CA

THBS1 THBS2 LRP4 LRP1B COMP

1.10e-1112255SM00179
DomainEGF-like_Ca-bd_dom

THBS1 THBS2 LRP4 LRP1B COMP

1.19e-1112455IPR001881
DomainTSP_type-3_rpt

THBS1 THBS2 COMP

9.21e-11553IPR028974
DomainTSP_3

THBS1 THBS2 COMP

9.21e-11553PF02412
DomainThrombospondin_C

THBS1 THBS2 COMP

9.21e-11553IPR008859
DomainThrombospondin_3-like_rpt

THBS1 THBS2 COMP

9.21e-11553IPR003367
DomainTSP_C

THBS1 THBS2 COMP

9.21e-11553PF05735
DomainTSP3

THBS1 THBS2 COMP

9.21e-11553PS51234
DomainTSP_CTER

THBS1 THBS2 COMP

9.21e-11553PS51236
DomainThrombospondin_3_rpt

THBS1 THBS2 COMP

9.21e-11553IPR017897
Domain-

THBS1 THBS2 COMP

9.21e-115534.10.1080.10
DomainEGF

THBS1 THBS2 LRP4 LRP1B COMP

3.02e-1023555SM00181
DomainEGF_3

THBS1 THBS2 LRP4 LRP1B COMP

3.02e-1023555PS50026
DomainEGF-like_dom

THBS1 THBS2 LRP4 LRP1B COMP

4.05e-1024955IPR000742
DomainEGF_1

THBS1 THBS2 LRP4 LRP1B COMP

4.56e-1025555PS00022
DomainEGF-like_CS

THBS1 THBS2 LRP4 LRP1B COMP

5.13e-1026155IPR013032
DomainEGF_2

THBS1 THBS2 LRP4 LRP1B COMP

5.54e-1026555PS01186
Domain-

THBS1 THBS2 COMP

1.27e-0695532.60.120.200
DomainEGF_Ca-bd_CS

LRP4 LRP1B COMP

1.35e-069753IPR018097
DomainEGF_CA

LRP4 LRP1B COMP

1.43e-069953PS01187
DomainEGF

THBS2 LRP4 LRP1B

2.97e-0612653PF00008
DomainLdl_recept_b

LRP4 LRP1B

5.21e-061452PF00058
DomainLDLRB

LRP4 LRP1B

5.21e-061452PS51120
DomainGrowth_fac_rcpt_

LRP4 LRP1B COMP

5.65e-0615653IPR009030
DomainLY

LRP4 LRP1B

6.01e-061552SM00135
DomainLDLR_classB_rpt

LRP4 LRP1B

6.01e-061552IPR000033
DomainTSPN

THBS1 THBS2

1.45e-052352SM00210
DomainConA-like_dom

THBS1 THBS2 COMP

1.56e-0521953IPR013320
DomaincEGF

LRP4 LRP1B

1.86e-052652PF12662
DomaincEGF

LRP4 LRP1B

1.86e-052652IPR026823
DomainVWC

THBS1 THBS2

2.16e-052852PF00093
DomainVWFC_1

THBS1 THBS2

3.60e-053652PS01208
DomainVWFC_2

THBS1 THBS2

4.02e-053852PS50184
DomainVWC

THBS1 THBS2

4.02e-053852SM00214
Domain-

LRP4 LRP1B

4.23e-0539522.120.10.30
DomainLDLR_class-A_CS

LRP4 LRP1B

4.45e-054052IPR023415
DomainVWF_dom

THBS1 THBS2

4.92e-054252IPR001007
DomainLdl_recept_a

LRP4 LRP1B

5.65e-054552PF00057
Domain-

LRP4 LRP1B

5.91e-0546524.10.400.10
Domain6-blade_b-propeller_TolB-like

LRP4 LRP1B

5.91e-054652IPR011042
DomainLDLRA_1

LRP4 LRP1B

6.44e-054852PS01209
DomainLDLa

LRP4 LRP1B

6.71e-054952SM00192
DomainLDLRA_2

LRP4 LRP1B

6.71e-054952PS50068
DomainLDrepeatLR_classA_rpt

LRP4 LRP1B

6.71e-054952IPR002172
DomainLaminin_G

THBS1 THBS2

9.42e-055852IPR001791
DomainTSP_1

THBS1 THBS2

1.11e-046352PF00090
DomainTSP1_rpt

THBS1 THBS2

1.18e-046552IPR000884
DomainTSP1

THBS1 THBS2

1.18e-046552PS50092
DomainTSP1

THBS1 THBS2

1.18e-046552SM00209
DomainASX_HYDROXYL

LRP4 LRP1B

2.81e-0410052PS00010
DomainEGF-type_Asp/Asn_hydroxyl_site

LRP4 LRP1B

3.16e-0410652IPR000152
PathwayKEGG_ECM_RECEPTOR_INTERACTION

THBS1 THBS2 COMP

2.02e-068453M7098
PathwayKEGG_TGF_BETA_SIGNALING_PATHWAY

THBS1 THBS2 COMP

2.17e-068653M2642
PathwayWP_FOCAL_ADHESION

THBS1 THBS2 COMP

2.71e-0519953M39402
PathwayKEGG_FOCAL_ADHESION

THBS1 THBS2 COMP

2.71e-0519953M7253
PathwayPID_INTEGRIN_A4B1_PATHWAY

THBS1 THBS2

5.29e-053352M277
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

THBS1 THBS2

7.42e-053952M27417
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

THBS1 THBS2

7.42e-053952MM15165
PathwayWP_MIRNA_TARGETS_IN_ECM_AND_MEMBRANE_RECEPTORS

THBS1 THBS2

9.04e-054352M39565
PathwayREACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

THBS1 LRP4 COMP

9.24e-0530053M610
PathwayWP_FOCAL_ADHESION_PI3KAKTMTORSIGNALING

THBS1 THBS2 COMP

9.43e-0530253M39719
PathwayWP_FOCAL_ADHESION_PI3KAKTMTOR_SIGNALING_PATHWAY

THBS1 THBS2 COMP

1.18e-0432653MM15917
PathwayWP_PI3KAKT_SIGNALING

THBS1 THBS2 COMP

1.33e-0433953M39736
PathwayREACTOME_SIGNALING_BY_PDGF

THBS1 THBS2

1.59e-045752MM14713
PathwayREACTOME_SIGNALING_BY_PDGF

THBS1 THBS2

1.65e-045852M2049
PathwayPID_INTEGRIN1_PATHWAY

THBS1 THBS2

2.14e-046652M18
PathwayREACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS

THBS1 THBS2

2.27e-046852M27303
PathwayREACTOME_ECM_PROTEOGLYCANS

LRP4 COMP

2.84e-047652M27219
PathwayREACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS

THBS1 COMP

2.84e-047652MM14867
PathwayREACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS

THBS1 COMP

3.55e-048552M16441
PathwayREACTOME_O_LINKED_GLYCOSYLATION

THBS1 THBS2

5.83e-0410952MM15164
PathwayREACTOME_O_LINKED_GLYCOSYLATION

THBS1 THBS2

6.05e-0411152M27416
PathwayREACTOME_DISEASES_OF_GLYCOSYLATION

THBS1 THBS2

1.00e-0314352M27275
PathwayWP_FOCAL_ADHESION

THBS1 THBS2

1.70e-0318752MM15913
PathwayREACTOME_DISEASES_OF_METABOLISM

THBS1 THBS2

3.02e-0325052M27554
PathwayREACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

THBS1 COMP

3.22e-0325852MM14572
PathwayWP_FATTY_ACIDS_AND_LIPOPROTEINS_TRANSPORT_IN_HEPATOCYTES

LRP4 LRP1B

6.90e-0338152M48063
PathwayREACTOME_SIGNALING_BY_RECEPTOR_TYROSINE_KINASES

THBS1 THBS2

8.27e-0341852MM15587
PathwayREACTOME_SIGNALING_BY_RECEPTOR_TYROSINE_KINASES

THBS1 THBS2

1.32e-0253252M27870
Pubmed

Thrombospondin-1, -2 and -5 have differential effects on vascular smooth muscle cell physiology.

THBS1 THBS2 COMP

1.43e-1235326168731
Pubmed

Thrombospondin-3 augments injury-induced cardiomyopathy by intracellular integrin inhibition and sarcolemmal instability.

THBS1 THBS2 COMP

1.43e-1155330622267
Pubmed

Thrombospondins 1 and 2 are important for afferent synapse formation and function in the inner ear.

THBS1 THBS2 COMP

7.99e-1185324460873
Pubmed

Induced thrombospondin expression in the mouse pancreas during pancreatic injury.

THBS1 THBS2

1.65e-0825216181801
Pubmed

Roles of thrombospondin-1 and -2 in regulating corneal and iris angiogenesis.

THBS1 THBS2

1.65e-0825215037577
Pubmed

THBS1 and THBS2 Enhance the In Vitro Proliferation, Adhesion, Migration and Invasion of Intrahepatic Cholangiocarcinoma Cells.

THBS1 THBS2

1.65e-0825238339060
Pubmed

Intermolecular interactions of thrombospondins drive their accumulation in extracellular matrix.

THBS1 COMP

1.65e-0825225995382
Pubmed

Expression of thrombospondin-1 in ischemia-induced retinal neovascularization.

THBS1 THBS2

1.65e-0825210027393
Pubmed

Immunochemical analysis of the structure of the signature domains of thrombospondin-1 and thrombospondin-2 in low calcium concentrations.

THBS1 THBS2

1.65e-0825217620335
Pubmed

Circulating Levels of Thrombospondin-1 and Thrombospondin-2 in Patients with Temporal Lobe Epilepsy Before and After Surgery.

THBS1 THBS2

1.65e-0825233372257
Pubmed

An association study of thrombospondin 1 and 2 SNPs with coronary artery disease and myocardial infarction among South Indians.

THBS1 THBS2

1.65e-0825221762961
Pubmed

TSP1 and TSP2 Have Unique and Overlapping Roles in Protecting against Noise-Induced Auditory Synaptopathy.

THBS1 THBS2

1.65e-0825230928339
Pubmed

Human cytomegalovirus infection modulates thrombospondins 1 and 2 in primary fetal astrocytes.

THBS1 THBS2

1.65e-0825223660684
Pubmed

Restricted localization of thrombospondin-2 protein during mouse embryogenesis: a comparison to thrombospondin-1.

THBS1 THBS2

1.65e-082529694593
Pubmed

Increased excitatory connectivity and epileptiform activity in thrombospondin1/2 knockout mice following cortical trauma.

THBS1 THBS2

1.65e-0825239122122
Pubmed

Compound deletion of thrombospondin-1 and -2 results in a skeletal phenotype not predicted by the single gene knockouts.

THBS1 THBS2

1.65e-0825234425286
Pubmed

The lack of thrombospondin-1 (TSP1) dictates the course of wound healing in double-TSP1/TSP2-null mice.

THBS1 THBS2

1.65e-0825212213711
Pubmed

Thrombospondin-1 (TSP1)-null and TSP2-null mice exhibit lower intraocular pressures.

THBS1 THBS2

1.65e-0825222930728
Pubmed

Thrombospondins deployed by thrombopoietic cells determine angiogenic switch and extent of revascularization.

THBS1 THBS2

1.65e-0825217143334
Pubmed

Circulating Levels of Thrombospondin-1 and Thrombospondin-2 in Patients with Common Brain Tumors.

THBS1 THBS2

1.65e-0825233759165
Pubmed

Modulation of thrombospondin expression during differentiation of embryonal carcinoma cells.

THBS1 THBS2

1.65e-082528126073
Pubmed

Contribution of Thrombospondin-1 and -2 to Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome.

THBS1 THBS2

1.65e-0825233981184
Pubmed

Variants within the COMP and THBS2 genes are not associated with Achilles tendinopathy in a case-control study of South African and Australian populations.

THBS2 COMP

1.65e-0825223875975
Pubmed

Thrombospondin expression in aldosterone-producing adenomas.

THBS1 THBS2

1.65e-0825212358136
Pubmed

Thrombospondins 1 and 2 are necessary for synaptic plasticity and functional recovery after stroke.

THBS1 THBS2

1.65e-0825218594557
Pubmed

A second, expressed thrombospondin gene (Thbs2) exists in the mouse genome.

THBS1 THBS2

1.65e-082521712771
Pubmed

Reduced expression of thrombospondins and craniofacial dysmorphism in mice overexpressing Fra1.

THBS1 THBS2

4.96e-0835216598380
Pubmed

Increased sensitivity to kindling in mice lacking TSP1.

THBS1 THBS2

4.96e-0835226241338
Pubmed

Expression and function of thrombospondin-1 in myelinating glial cells of the central nervous system.

THBS1 THBS2

4.96e-083529373030
Pubmed

Differential Expression Pattern of THBS1 and THBS2 in Lung Cancer: Clinical Outcome and a Systematic-Analysis of Microarray Databases.

THBS1 THBS2

4.96e-0835227513329
Pubmed

Thrombospondin-1 and CD47 limit cell and tissue survival of radiation injury.

THBS1 THBS2

4.96e-0835218787106
Pubmed

Regulation of VEGF-A, VEGFR-I, thrombospondin-1, -2, and -3 expression in a human pituitary cell line (HP75) by TGFbeta1, bFGF, and EGF.

THBS1 THBS2

4.96e-0835215347840
Pubmed

TSP1 and TSP2 deficiencies affect LOX protein distribution in the femoral diaphysis and pro-peptide removal in marrow-derived mesenchymal stem cells in vitro.

THBS1 THBS2

4.96e-0835230939949
Pubmed

Extracellular matrix retention of thrombospondin 1 is controlled by its conserved C-terminal region.

THBS1 COMP

4.96e-0835218285447
Pubmed

Thrombospondins use the VLDL receptor and a nonapoptotic pathway to inhibit cell division in microvascular endothelial cells.

THBS1 THBS2

4.96e-0835218032585
Pubmed

Polymorphisms in thrombospondin genes and myocardial infarction: a case-control study and a meta-analysis of available evidence.

THBS1 THBS2

4.96e-0835218178577
Pubmed

Association between single nucleotide polymorphisms in thrombospondins genes and coronary artery disease: A meta-analysis.

THBS1 THBS2

4.96e-0835225976449
Pubmed

Interactions between CD47 and thrombospondin reduce inflammation.

THBS1 THBS2

4.96e-0835217442977
Pubmed

Differential interactions of thrombospondin-1, -2, and -4 with CD47 and effects on cGMP signaling and ischemic injury responses.

THBS1 THBS2

4.96e-0835219004835
Pubmed

Differential expression of thrombospondin 1, 2, and 3 during murine development.

THBS1 THBS2

4.96e-083528400410
Pubmed

Thrombospondin is a tight-binding competitive inhibitor of neutrophil elastase.

THBS1 THBS2

4.96e-083528463250
Pubmed

The Pathological Significance and Prognostic Roles of Thrombospondin-1, and -2, and 4N1K-peptide in Bladder Cancer.

THBS1 THBS2

4.96e-0835231092423
Pubmed

Gabapentin receptor alpha2delta-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesis.

THBS1 THBS2

4.96e-0835219818485
Pubmed

Thrombospondin-2 polymorphism is associated with a reduced risk of premature myocardial infarction.

THBS1 THBS2

4.96e-0835212482844
Pubmed

ADAMTS-7 inhibits re-endothelialization of injured arteries and promotes vascular remodeling through cleavage of thrombospondin-1.

THBS1 COMP

4.96e-0835225712208
Pubmed

mRNA Expression of thrombospondin 1, 2 and 3 from proximal to distal in human abdominal aortic aneurysm - preliminary report.

THBS1 THBS2

4.96e-0835234669362
Pubmed

Thrombospondin 1 and thrombospondin 2 are expressed as both homo- and heterotrimers.

THBS1 THBS2

4.96e-083521459996
Pubmed

Cocaine Triggers Astrocyte-Mediated Synaptogenesis.

THBS1 THBS2

4.96e-0835233069367
Pubmed

EWS/FLI1 regulates tumor angiogenesis in Ewing's sarcoma via suppression of thrombospondins.

THBS1 THBS2

4.96e-0835217638877
Pubmed

Recognition of the N-terminal modules of thrombospondin-1 and thrombospondin-2 by alpha6beta1 integrin.

THBS1 THBS2

9.92e-0845212909644
Pubmed

Thrombospondin 2 potentiates notch3/jagged1 signaling.

THBS1 THBS2

9.92e-0845219147503
Pubmed

Interactions of thrombospondins with alpha4beta1 integrin and CD47 differentially modulate T cell behavior.

THBS1 THBS2

9.92e-0845211980922
Pubmed

Thrombospondin type 1 repeats interact with matrix metalloproteinase 2. Regulation of metalloproteinase activity.

THBS1 THBS2

9.92e-0845210900205
Pubmed

Immunohistochemical localisation of thrombospondin in human megakaryocytes and platelets.

THBS1 THBS2

9.92e-084526338048
Pubmed

Spontaneous bacterial keratitis in CD36 knockout mice.

THBS1 THBS2

9.92e-0845220847111
Pubmed

Thrombospondin-1 and thrombospondin-2 mRNA and TSP-1 and TSP-2 protein expression in uterine fibroids and correlation to the genes COL1A1 and COL3A1 and to the collagen cross-link hydroxyproline.

THBS1 THBS2

9.92e-0845218089612
Pubmed

Ectodomains of the LDL receptor-related proteins LRP1b and LRP4 have anchorage independent functions in vivo.

LRP4 LRP1B

1.65e-0755220383322
Pubmed

Central corneal thickness does not correlate with TonoLab-measured IOP in several mouse strains with single transgenic mutations of matricellular proteins.

THBS1 THBS2

1.65e-0755223806329
Pubmed

Skeletal abnormalities in mice lacking extracellular matrix proteins, thrombospondin-1, thrombospondin-3, thrombospondin-5, and type IX collagen.

THBS1 COMP

1.65e-0755218467703
Pubmed

Characterization of mouse thrombospondin 2 sequence and expression during cell growth and development.

THBS1 THBS2

5.95e-079521371115
Pubmed

Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins.

THBS1 THBS2 COMP

7.20e-071465327068509
Pubmed

LRP2 mediates folate uptake in the developing neural tube.

LRP4 LRP1B

9.09e-07115224639464
Pubmed

Sema3F (Semaphorin 3F) Selectively Drives an Extraembryonic Proangiogenic Program.

THBS1 THBS2

1.50e-06145228729362
Pubmed

Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects.

THBS1 THBS2 COMP

2.15e-062105316537572
Pubmed

MESD is essential for apical localization of megalin/LRP2 in the visceral endoderm.

LRP4 LRP1B

3.47e-06215221337463
Pubmed

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.

THBS1 THBS2 COMP

3.54e-062485324006456
Pubmed

Forkhead box transcription factor FoxC1 preserves corneal transparency by regulating vascular growth.

THBS1 THBS2

7.18e-06305222171010
Pubmed

TBX1 is required for normal stria vascularis and semicircular canal development.

THBS1 COMP

7.68e-06315231550482
Pubmed

Synaptic hyperexcitability of cytomegalic pyramidal neurons contributes to epileptogenesis in tuberous sclerosis complex.

THBS1 THBS2

9.82e-06355235858542
Pubmed

Myh10 deficiency leads to defective extracellular matrix remodeling and pulmonary disease.

THBS1 THBS2

2.19e-05525230389913
Pubmed

GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrier.

THBS1 THBS2

2.82e-05595221421844
Pubmed

O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.

THBS1 THBS2

4.57e-05755220637190
Pubmed

Comprehensive proteomic characterization of stem cell-derived extracellular matrices.

THBS1 THBS2

6.01e-05865228327460
Pubmed

Proteomics characterization of extracellular space components in the human aorta.

THBS1 COMP

8.30e-051015220551380
Pubmed

Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population.

THBS1 THBS2

1.08e-041155220485444
InteractionZNF563 interactions

LRP4 LRP1B

3.25e-061252int:ZNF563
InteractionDEFB123 interactions

LRP4 LRP1B

5.90e-061652int:DEFB123
InteractionTHBS2 interactions

THBS1 THBS2

8.41e-061952int:THBS2
InteractionZNF224 interactions

LRP4 LRP1B

9.34e-062052int:ZNF224
InteractionNTN5 interactions

LRP4 LRP1B

1.36e-052452int:NTN5
InteractionFEZF1 interactions

LRP4 LRP1B

1.86e-052852int:FEZF1
InteractionZFP41 interactions

LRP4 LRP1B

7.82e-055752int:ZFP41
InteractionANKRD36B interactions

LRP4 LRP1B

8.67e-056052int:ANKRD36B
InteractionHRG interactions

THBS1 LRP1B

9.56e-056352int:HRG
InteractionZNF331 interactions

LRP4 LRP1B

9.56e-056352int:ZNF331
InteractionCOL2A1 interactions

THBS1 COMP

9.87e-056452int:COL2A1
InteractionMMP9 interactions

THBS1 THBS2

1.08e-046752int:MMP9
InteractionTHBS3 interactions

THBS1 THBS2

1.32e-047452int:THBS3
InteractionIGFL3 interactions

LRP4 LRP1B

1.36e-047552int:IGFL3
InteractionMMP2 interactions

THBS1 THBS2

1.83e-048752int:MMP2
InteractionDYRK1A interactions

THBS1 LRP4 LRP1B

1.96e-0455253int:DYRK1A
InteractionFGA interactions

THBS1 LRP1B

2.18e-049552int:FGA
InteractionFGG interactions

THBS1 LRP1B

2.66e-0410552int:FGG
InteractionLRP5 interactions

THBS1 LRP4

2.87e-0410952int:LRP5
InteractionFCGRT interactions

THBS1 LRP4

3.25e-0411652int:FCGRT
InteractionSULF2 interactions

LRP4 LRP1B

3.42e-0411952int:SULF2
InteractionTHBS1 interactions

THBS1 THBS2

3.89e-0412752int:THBS1
InteractionZSCAN21 interactions

LRP4 LRP1B

3.95e-0412852int:ZSCAN21
InteractionZNF408 interactions

LRP4 LRP1B

5.07e-0414552int:ZNF408
InteractionLRP2 interactions

THBS1 LRP1B

5.71e-0415452int:LRP2
InteractionLRPAP1 interactions

LRP4 LRP1B

7.79e-0418052int:LRPAP1
InteractionLRP1 interactions

THBS1 LRP1B

9.23e-0419652int:LRP1
InteractionFGB interactions

THBS1 LRP1B

9.51e-0419952int:FGB
InteractionLCOR interactions

LRP4 LRP1B

1.40e-0324252int:LCOR
InteractionTIMP2 interactions

THBS1 THBS2

1.83e-0327752int:TIMP2
InteractionARRB1 interactions

LRP4 LRP1B

2.20e-0330452int:ARRB1
InteractionDISC1 interactions

THBS1 LRP4

4.33e-0342952int:DISC1
InteractionRPL10 interactions

LRP4 LRP1B

1.13e-0270252int:RPL10
GeneFamilyLow density lipoprotein receptors

LRP4 LRP1B

4.77e-071322634
CoexpressionNABA_MATRISOME_HGSOC_OMENTAL_METASTASIS

THBS1 THBS2 COMP

1.08e-075953M47993
CoexpressionDELYS_THYROID_CANCER_UP

THBS1 THBS2 LRP4 COMP

4.04e-0744554M3645
CoexpressionVERRECCHIA_RESPONSE_TO_TGFB1_C4

THBS1 THBS2

1.60e-061152M566
CoexpressionLY_AGING_MIDDLE_UP

THBS2 COMP

2.65e-061452M19146
CoexpressionNABA_ECM_GLYCOPROTEINS

THBS1 THBS2 COMP

3.77e-0619153MM17059
CoexpressionNABA_ECM_GLYCOPROTEINS

THBS1 THBS2 COMP

4.07e-0619653M3008
CoexpressionHALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION

THBS1 THBS2 COMP

4.33e-0620053M5930
CoexpressionNABA_CORE_MATRISOME

THBS1 THBS2 COMP

1.06e-0527053MM17057
CoexpressionNABA_CORE_MATRISOME

THBS1 THBS2 COMP

1.12e-0527553M5884
CoexpressionNABA_MATRISOME_METASTATIC_COLORECTAL_LIVER_METASTASIS

THBS2 COMP

1.26e-053052M47990
CoexpressionLIEN_BREAST_CARCINOMA_METAPLASTIC

THBS1 THBS2

1.53e-053352M11654
CoexpressionVERRECCHIA_DELAYED_RESPONSE_TO_TGFB1

THBS1 THBS2

1.93e-053752M16643
CoexpressionBOQUEST_STEM_CELL_CULTURED_VS_FRESH_UP

THBS1 LRP1B COMP

4.19e-0542753M17923
CoexpressionGERHOLD_ADIPOGENESIS_DN

THBS1 THBS2

5.48e-056252M1576
CoexpressionANASTASSIOU_MULTICANCER_INVASIVENESS_SIGNATURE

THBS2 COMP

5.84e-056452M2572
CoexpressionGERHOLD_ADIPOGENESIS_DN

THBS1 THBS2

5.84e-056452MM671
CoexpressionTURASHVILI_BREAST_LOBULAR_CARCINOMA_VS_DUCTAL_NORMAL_UP

THBS2 COMP

6.79e-056952M10165
CoexpressionTURASHVILI_BREAST_LOBULAR_CARCINOMA_VS_LOBULAR_NORMAL_DN

THBS2 COMP

7.82e-057452M13547
CoexpressionNAKAYAMA_SOFT_TISSUE_TUMORS_PCA1_UP

THBS1 THBS2

9.85e-058352M17951
CoexpressionZHU_CMV_24_HR_DN

THBS1 THBS2

1.01e-048452M4065
CoexpressionDESCARTES_FETAL_EYE_STROMAL_CELLS

THBS1 THBS2

1.18e-049152M40180
CoexpressionKIM_MYCN_AMPLIFICATION_TARGETS_UP

LRP4 COMP

1.24e-049352M18532
CoexpressionZHU_CMV_ALL_DN

THBS1 THBS2

2.03e-0411952M14555
CoexpressionCHIARADONNA_NEOPLASTIC_TRANSFORMATION_CDC25_UP

THBS1 THBS2

2.09e-0412152M12828
CoexpressionCHEBOTAEV_GR_TARGETS_DN

THBS2 LRP4

2.20e-0412452M7876
CoexpressionCHEBOTAEV_GR_TARGETS_DN

THBS2 LRP4

2.49e-0413252MM470
CoexpressionCHIARADONNA_NEOPLASTIC_TRANSFORMATION_CDC25_UP

THBS1 THBS2

2.49e-0413252MM465
CoexpressionHALLMARK_COAGULATION

THBS1 COMP

2.72e-0413852M5946
CoexpressionVECCHI_GASTRIC_CANCER_ADVANCED_VS_EARLY_UP

THBS1 THBS2

4.52e-0417852M17079
CoexpressionWANG_CISPLATIN_RESPONSE_AND_XPC_UP

THBS1 THBS2

4.89e-0418552M19511
CoexpressionNABA_MATRISOME

THBS1 THBS2 COMP

5.35e-04100853MM17056
CoexpressionAIZARANI_LIVER_C21_STELLATE_CELLS_1

THBS1 THBS2

5.37e-0419452M39122
CoexpressionGSE22886_IL2_VS_IL15_STIM_NKCELL_UP

THBS1 THBS2

5.48e-0419652M4514
CoexpressionNABA_MATRISOME

THBS1 THBS2 COMP

5.64e-04102653M5889
CoexpressionGSE17721_CTRL_VS_POLYIC_0.5H_BMDC_UP

LRP4 LRP1B

5.71e-0420052M3705
CoexpressionGSE22025_UNTREATED_VS_TGFB1_AND_PROGESTERONE_TREATED_CD4_TCELL_UP

THBS2 LRP4

5.71e-0420052M8383
CoexpressionGSE2585_THYMIC_DC_VS_MTEC_DN

THBS1 THBS2

5.71e-0420052M6283
CoexpressionGSE15767_MED_VS_SCS_MAC_LN_UP

THBS1 LRP4

5.71e-0420052M3584
CoexpressionWINTER_HYPOXIA_METAGENE

THBS1 THBS2

8.40e-0424352M14072
CoexpressionBOQUEST_STEM_CELL_UP

THBS2 LRP1B

9.68e-0426152M1834
CoexpressionMCBRYAN_PUBERTAL_BREAST_4_5WK_UP

THBS1 THBS2

1.04e-0327052M19432
CoexpressionNAKAMURA_TUMOR_ZONE_PERIPHERAL_VS_CENTRAL_UP

THBS1 LRP4

1.14e-0328452M16975
CoexpressionMCBRYAN_PUBERTAL_BREAST_4_5WK_UP

THBS1 THBS2

1.14e-0328452MM987
CoexpressionSCHUETZ_BREAST_CANCER_DUCTAL_INVASIVE_UP

THBS2 COMP

1.75e-0335252M17471
CoexpressionREN_ALVEOLAR_RHABDOMYOSARCOMA_DN

THBS1 THBS2

2.33e-0340752M19541
CoexpressionLIM_MAMMARY_STEM_CELL_UP

THBS1 LRP4

3.21e-0347952M2573
CoexpressionLIM_MAMMARY_STEM_CELL_UP

THBS1 LRP4

3.27e-0348352MM1082
CoexpressionMURARO_PANCREAS_MESENCHYMAL_STROMAL_CELL

THBS1 THBS2

6.40e-0368152M39175
CoexpressionAtlasBM Top 100 - saphenous vein

THBS1 COMP

1.03e-046952BM Top 100 - saphenous vein
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ bladder_emap-6668_k-means-cluster#3_top-relative-expression-ranked_500

THBS1 THBS2

1.16e-047352DevelopingLowerUrinaryTract_e14.5_ bladder_emap-6668_k3_500
CoexpressionAtlasJC_fibro_top-relative-expression-ranked_500

THBS1 THBS2 COMP

1.21e-0449453JC_fibro_500
CoexpressionAtlasStromal Cells, FRC.SLN, gp38+ CD31- CD140a+, Lymph Node, avg-4

THBS1 THBS2

1.61e-048652GSM777055_100
CoexpressionAtlasDevelopingKidney_e15.5_Pelvic Mesenchyme_emap-8241_top-relative-expression-ranked_100

THBS1 THBS2

1.61e-048652gudmap_developingKidney_e15.5_Pelvic Mesenchyme_100
CoexpressionAtlasStromal Cells, FRC.MLN, gp38+ CD31- CD140a+, Lymph Node, avg-5

THBS1 THBS2

1.65e-048752GSM777050_100
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ bladder_emap-6668_k-means-cluster#4_top-relative-expression-ranked_1000

THBS1 THBS2

1.96e-049552DevelopingLowerUrinaryTract_e14.5_ bladder_emap-6668_k4_1000
CoexpressionAtlasDevelopingLowerUrinaryTract_P1_bladder_J_emap-30374_k-means-cluster#2_top-relative-expression-ranked_500

THBS1 THBS2

2.40e-0410552gudmap_developingLowerUrinaryTract_P1_bladder_J_500_k2
CoexpressionAtlasJC_iEC_top-relative-expression-ranked_2500_k-means-cluster#1

THBS1 THBS2 LRP4

3.01e-0467253JC_iEC_2500_K1
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ bladder_emap-30872_k-means-cluster#4_top-relative-expression-ranked_1000

THBS1 THBS2

3.79e-0413252gudmap_developingLowerUrinaryTract_e14.5_ bladder_1000_k4
CoexpressionAtlasgallbladder

THBS2 COMP

4.76e-0414852gallbladder
CoexpressionAtlasDevelopingLowerUrinaryTract_P1_bladder_J_emap-30374_k-means-cluster#1_top-relative-expression-ranked_1000

THBS1 THBS2

4.82e-0414952gudmap_developingLowerUrinaryTract_P1_bladder_J_1000_k1
CoexpressionAtlasDevelopingKidney_e15.5_Pelvic Mesenchyme_emap-8241_top-relative-expression-ranked_200

THBS1 THBS2

5.84e-0416452gudmap_developingKidney_e15.5_Pelvic Mesenchyme_200
CoexpressionAtlasDevelopingLowerUrinaryTract_P1_ureter_emap-30363_k-means-cluster#2_top-relative-expression-ranked_1000

THBS1 THBS2

7.34e-0418452gudmap_developingLowerUrinaryTract_P1_ureter_1000_k2
CoexpressionAtlasProgenitor-Cell-Biology-Consortium_reference_BronchSmoothMuscl_top-relative-expression-ranked_1000

THBS1 THBS2 COMP

9.17e-0498153PCBC_ctl_BronchSmoothMuscl_1000
CoexpressionAtlasJC_fibro_top-relative-expression-ranked_1000

THBS1 THBS2 COMP

9.41e-0499053JC_fibro_1000
CoexpressionAtlasDevelopingLowerUrinaryTract_P1_bladder_J_emap-30374_k-means-cluster#2_top-relative-expression-ranked_1000

THBS1 THBS2

1.36e-0325152gudmap_developingLowerUrinaryTract_P1_bladder_J_1000_k2
ToppCellfacs-Skin-nan-24m-Epithelial-basal_cell_of_epidermis|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THBS1 THBS2 LRP4

5.75e-071755321542be95059983d2c8bdf01ec711fdbf1ec1f62
ToppCell5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

THBS2 LRP4 COMP

6.37e-0718153b116c68393d8836bac080f81a8fcbeb52e0403e7
ToppCellFetal_29-31_weeks-Mesenchymal-myofibroblast_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

THBS1 THBS2 LRP4

6.47e-0718253ed6ae0fd8653f213fe29906a6a4e0729a62e1b75
ToppCelldroplet-Limb_Muscle-Pre-Sort-18m-Mesenchymal|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THBS1 THBS2 COMP

6.69e-0718453c9d7ec17cc5b7ba1b1e721ca392746e8f4a3d41f
ToppCell5'-Adult-Appendix-Mesenchymal-fibroblastic-mLN_Stroma_(FMO2+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

THBS1 THBS2 LRP1B

6.91e-07186537582b5154d8e5a4434817b5ab77a10b789ea2288
ToppCellfacs-Skin-Telogen-3m-Epithelial-Basal_IFE|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THBS1 THBS2 LRP4

7.14e-07188538cc927b4c51d982fdafa04dc7393617ad9bb220e
ToppCellfacs-Skin-nan-18m-Epithelial-Basal_IFE|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THBS1 THBS2 LRP4

7.25e-07189536c71e81373cb7822de23c193a6350b6df9f567bc
ToppCellfacs-Skin-Skin_Anagen-18m-Epithelial-Basal_IFE|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THBS1 THBS2 LRP4

7.25e-07189531cfc1fe27c4b57b4e52700fa8f679ce172cee5a9
ToppCelldroplet-Limb_Muscle-Pre-Sort-18m-Mesenchymal-mesenchymal_stem_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THBS1 THBS2 COMP

7.48e-07191531b26056df078674f37a6c06f6256b30cfcec21a7
ToppCelldroplet-Limb_Muscle-Pre-Sort-18m-Mesenchymal-chondrocyte-like|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THBS1 THBS2 COMP

7.60e-0719253b35f0e422070ba9c7c1d9ff3eace4edc10286cde
ToppCelldroplet-Limb_Muscle-nan-21m-Mesenchymal-chondrocyte-like|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THBS1 THBS2 COMP

7.97e-0719553d2c9c58b46bf96f9a536e177b995e340b55c6750
ToppCellASK428-Mesenchymal-Fibroblast|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq

THBS1 THBS2 COMP

7.97e-0719553c269c0d894a0f55da6495b59d4b9abb9f68df684
ToppCellASK428-Mesenchymal|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq

THBS1 THBS2 COMP

7.97e-07195532b156163975d9a3d3fda1402acd9831d0fdc9e25
ToppCelldroplet-Limb_Muscle-nan-18m-Mesenchymal-chondrocyte-like|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THBS1 THBS2 COMP

8.09e-0719653fcb275746bf51269ed8ba4cf93edb054a45f1ccd
ToppCelldroplet-Limb_Muscle-nan-24m-Mesenchymal-chondrocyte-like|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THBS1 THBS2 COMP

8.09e-071965361bee32ca299219f31a30b57124e44e85b798e9f
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Mesenchymal-chondrocyte-like|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THBS1 THBS2 COMP

8.21e-0719753cfd4cc5fb8d7a60dd5c0d2a1a7bad7ba38c19d40
ToppCelldroplet-Limb_Muscle-nan-3m-Mesenchymal-chondrocyte-like|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THBS1 THBS2 COMP

8.47e-0719953edd5300da1a3b758210ff8f949e9d1988b8bc7e2
ToppCellGlobus_pallidus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_2|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

THBS2 COMP

5.58e-05107528bdfb603ee0e8ca667847be016a9ee5f4f1712f8
ToppCellGlobus_pallidus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_2-Endothelial_Tip.Dcn.Ifitm1_(Ifitm1)|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

THBS2 COMP

5.58e-05107527dda60d30c12d9ee15cda5fcbc75c317ca2d026f
ToppCellGlobus_pallidus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_2-Endothelial_Tip.Dcn.Ifitm1_(Ifitm1)-|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

THBS2 COMP

5.58e-05107525356499561a62a80ecd7d9a260aea87bc70543fd
ToppCell-IPF_04|World / lung cells shred on cell class, cell subclass, sample id

THBS2 COMP

7.99e-0512852dab10774bc0532a1664fd8ac2b54cffab01be55a
ToppCellSubstantia_nigra-Endothelial-ENDOTHELIAL_TIP-Dcn_1|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

THBS2 COMP

8.49e-0513252893b7ec2a2d8a140cc98575d1beca1189f053e9a
ToppCellStriatum-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3-MURAL_Mural.Rgs5Acta2.Col3a1_(Mural.Rgs5Acta2.Col3a1)-|Striatum / BrainAtlas - Mouse McCarroll V32

THBS1 THBS2

8.75e-0513452a3547a68012d879d4dfe80394eace70808722e43
ToppCellStriatum-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3-MURAL_Mural.Rgs5Acta2.Col3a1_(Mural.Rgs5Acta2.Col3a1)|Striatum / BrainAtlas - Mouse McCarroll V32

THBS1 THBS2

8.75e-05134529458e2d0dbc18d9025b66b59f3ecc2fbc5384940
ToppCell(0)_Normal/No_Treatment-(4)_COL2.3+_osteoblasts|World / Stress and Cell class

THBS1 LRP4

1.05e-041475287c24843cb0e87ad42e725d08423131a5d2d25a3
ToppCellFetal_29-31_weeks-Mesenchymal-chondrocyte-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

THBS1 THBS2

1.14e-041535265641cc82883716dba0fefb749a30174a63f4da5
ToppCellBasal_cells-Donor_05|World / lung cells shred on cell class, cell subclass, sample id

LRP4 LRP1B

1.17e-041555230accc72a6a914ae0c4d52b373ea1c9a98efbf22
ToppCellSubstantia_nigra-Endothelial-ENDOTHELIAL_TIP|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

THBS2 COMP

1.23e-0415952cb2470b288c13e454a2a80115b0d5613b3f718e6
ToppCell(1)_Control_(PBS)-(4)_COL2.3+_osteoblasts|World / Stress and Cell class

THBS1 LRP4

1.25e-0416052ab769516f9f7798d1390ef215caf22a2d3d53e63
ToppCellfacs-Pancreas-Exocrine-24m-Epithelial-pancreatic_acinar_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP4 COMP

1.26e-0416152b9a17f41426bf715f30bf544a6795afaf37a3aa6
ToppCellfacs-Pancreas-Exocrine-24m-Epithelial-pancreatic_acinar_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP4 COMP

1.26e-0416152f7a89c481f789f624102857be722c95fbeb47595
ToppCelldroplet-Spleen-nan-18m-Myeloid-granulocyte|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THBS1 LRP4

1.30e-0416352bc37c5d9f48b16096d5313657563f3ec84028c8c
ToppCellnormal_Lung-Fibroblasts-Myofibroblasts|Fibroblasts / Location, Cell class and cell subclass

THBS2 COMP

1.31e-04164529b4a6007abae992db871d9f6f731d5af724de30d
ToppCellGlobus_pallidus-Endothelial-ENDOTHELIAL_TIP-Dcn_1|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

THBS2 COMP

1.33e-0416552570483b43ccb5831feec9337b4664814431d40b1
ToppCelldroplet-Spleen-SPLEEN-1m-Myeloid-granulocyte|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THBS1 LRP4

1.33e-0416552b671c6a950e70f64776c2104baccb3dc2bb6a1ba
ToppCellGlobus_pallidus-Endothelial-ENDOTHELIAL_TIP|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

THBS2 COMP

1.33e-04165522026a9a07f4d314cc05c167e491312b373468e46
ToppCellPND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-Chondrocyte|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

THBS2 COMP

1.34e-041665281c546c6d847e49e662b81e71992ca0f7a99e890
ToppCellPND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-Chondrocyte-Chondrocyte_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

THBS2 COMP

1.34e-041665237794a84601a2a949d579663d4a4bb8bc8fb5923
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Degenerative_Vascular_Smooth_Muscle_Cell-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

THBS2 COMP

1.36e-04167524e58f9bf1e9d47720c871776ec34513ded4de9b7
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Degenerative_Vascular_Smooth_Muscle_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

THBS2 COMP

1.36e-04167524ae9f2c5df13463709ea880ab035965fd99e7626
ToppCellTCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Squamous_Cell_Carcinoma-4|TCGA-Lung / Sample_Type by Project: Shred V9

THBS1 THBS2

1.38e-0416852aefea14b8b1c1b6a05f827effd22ba15274fddc9
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

THBS2 COMP

1.38e-04168524b2d29a7843bf45922038c093ca7ec0600756adc
ToppCellHippocampus-Endothelial-ENDOTHELIAL_TIP|Hippocampus / BrainAtlas - Mouse McCarroll V32

THBS2 COMP

1.38e-041685226aa96b2b547d11941cb803995ea3d302ee0518c
ToppCell367C-Fibroblasts-Fibroblast-A_(Fibroblast_progenitors)-|367C / Donor, Lineage, Cell class and subclass (all cells)

THBS2 COMP

1.39e-0416952e09259d62cd3e42f0919f231ed1164db59b0b6c3
ToppCell367C-Fibroblasts-Fibroblast-A_(Fibroblast_progenitors)|367C / Donor, Lineage, Cell class and subclass (all cells)

THBS2 COMP

1.39e-041695247fd4adfe54777e69a0fabf8bd34f26223f63275
ToppCell10x5'-Liver-Myeloid_Mac-Intermediate_macrophages|Liver / Manually curated celltypes from each tissue

THBS1 COMP

1.43e-041715225e0333743affdb662223fb5220b8a61fa02ad9f
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

THBS2 COMP

1.43e-04171525d31fc9b60329d4ae3c77e4ca679359d9314397d
ToppCellLPS-IL1RA-Epithelial_alveolar-Mes-like-AT2_Progenitor|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

LRP1B COMP

1.43e-0417152ca2775a17b5c339c480a963953b6fa2b0731f24d
ToppCellLPS-IL1RA-Epithelial_alveolar-Mes-like|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

LRP1B COMP

1.43e-04171523ad4f138d9570500cfb4423a2be16bb7d1cacbf8
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

THBS1 LRP4

1.43e-0417152effcc4b6d26eafc2ca6fa08b6fee2689eff48f0f
ToppCell(0)_Normal/No_Treatment-(4)_COL2.3+_osteoblasts|(0)_Normal/No_Treatment / Stress and Cell class

THBS1 LRP4

1.46e-0417352c2a0f674681836b5a868c13f67caa7d555ef6519
ToppCellfacs-Trachea-nan-24m-Mesenchymal-chondrocyte|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THBS1 COMP

1.46e-04173522226505610af1becc253d0a5550627144ef0ed6b
ToppCellMesenchymal_cells-Osteo-CAR|Mesenchymal_cells / Lineage and Cell class

LRP4 COMP

1.48e-0417452430e3cd61bc2a471959faa40e817aa4dd7d82d28
ToppCell3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

THBS2 COMP

1.49e-04175521799a7be623dc3bf53ba580a7c47d2619969d708
ToppCellfacs-Lung-ENDOMUCIN-18m-Endothelial-Lymphatic_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THBS2 COMP

1.49e-04175529d082ba0e350162aa6e71b668be074b12a27c7ab
ToppCellfacs-Lung-ENDOMUCIN-18m-Endothelial-endothelial_cell_of_lymphatic_vessel|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THBS2 COMP

1.49e-0417552f641f34b52aec5d047430a6f9d026e915da6c11d
ToppCell343B-Fibroblasts-Fibroblast-A_(Fibroblast_progenitors)-|343B / Donor, Lineage, Cell class and subclass (all cells)

THBS2 LRP1B

1.51e-04176522e94bbe17c0bb65dc58b4ebc0cb829258bd7373b
ToppCellfacs-Trachea-24m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l34|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

THBS1 COMP

1.51e-041765277c3da2eaa072a6baefb5087fd07ec18c5e271cd
ToppCellfacs-Heart-RV-18m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THBS2 LRP4

1.51e-0417652c0a084f7a8645262d61971f094689e02bf15b113
ToppCellfacs-Heart-RV-18m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THBS2 LRP4

1.51e-0417652cccf9201f6e2da7524b911a5961d3b227edab222
ToppCell343B-Fibroblasts-Fibroblast-A_(Fibroblast_progenitors)|343B / Donor, Lineage, Cell class and subclass (all cells)

THBS2 LRP1B

1.51e-0417652f33ab41d121b59d871ad7d48ca021524a027d2ef
ToppCellTCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Adenocarcinoma_Mixed_Subtype-4|TCGA-Lung / Sample_Type by Project: Shred V9

THBS2 COMP

1.51e-04176520923b01137d6f9956ca815b41102c81e82624065
ToppCell10x3'2.3-week_17-19-Mesenchymal_osteo-stroma-chondrocyte|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

THBS2 COMP

1.53e-0417752915b848d789051a1c3bc6f6dc86955bb752276ab
ToppCellTCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-6|TCGA-Ovary / Sample_Type by Project: Shred V9

THBS1 THBS2

1.54e-0417852142879e9393e721f9b05a6bb46995c9d6d713c95
ToppCellTCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Rectal_Adenocarcinoma-7|TCGA-Colorectal / Sample_Type by Project: Shred V9

THBS2 COMP

1.54e-0417852edc76b8f15056ec1c9a1c61a048b6331a92592d6
ToppCellE16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_G2M|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

THBS2 LRP4

1.54e-0417852c87945146b2734141f07b39d268e0d8086ee0364
ToppCellPosterior_cortex-Endothelial-ENDOTHELIAL_TIP|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

THBS2 COMP

1.54e-0417852cda7695411655bd6d0ba69e5041ca7530a9dad3a
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

THBS1 THBS2

1.58e-0418052fdbd7c22044d9328a1e06e2f9a4451529d1df767
ToppCellfacs-Pancreas-Exocrine-24m|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1B COMP

1.58e-041805272310baeed848f2c483ae986cd73d2fb2cca7feb
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

THBS1 THBS2

1.58e-0418052280ff5c8f292be1b88120db5ff1788b750644856
ToppCellmetastatic_Brain-Fibroblasts-Myofibroblasts|metastatic_Brain / Location, Cell class and cell subclass

THBS2 COMP

1.60e-0418152bd0b5f74f9c81ec0f1592710774a4fdf33d9d5a9
ToppCell(2)_5-FU-(4)_COL2.3+_osteoblasts|(2)_5-FU / Stress and Cell class

THBS1 LRP4

1.60e-041815256ae86072858c156681507aecd1bc6cb0a3372d2
ToppCell5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

THBS2 COMP

1.60e-0418152eea943fdcbef0bbaa8578f3296923e874893b405
ToppCellfacs-Lung-18m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

THBS2 COMP

1.60e-0418152cc77ac0e223e012767222e45c5dcadc246d1aa7c
ToppCell5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

THBS2 COMP

1.60e-04181529c157de9d3403e092c907599f2a2c16db5b21131
ToppCell5'-Adult-LymphNode-Mesenchymal-fibroblastic-Transitional_Stromal_3_(C3+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

THBS1 THBS2

1.60e-0418152ab66a89f316b935d9ba1277426d976b1e9e39757
ToppCellfacs-Lung-18m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

THBS2 COMP

1.60e-0418152b0fff0defba9aea6fba36e378b05a59986e2573a
ToppCellfacs-Lung-18m-Endothelial-lymphatic_endothelial|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

THBS2 COMP

1.60e-0418152ecd52f33841f4e9d946a4edad0d58da9b0cc5ffa
ToppCellAnterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Oligo-OPC-OPC_L1-6_MYT1|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

THBS2 LRP4

1.61e-04182525d909e4b5f662905bf1be9c686bbddc3e87d2be9
ToppCellfacs-Skin-Anagen-3m-Epithelial-Basal_IFE|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THBS2 LRP4

1.61e-041825222d6f4790950508e8aa27e02a8133af5f53f13c8
ToppCellAnterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Oligo-OPC|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

THBS2 LRP4

1.61e-04182523cc61f5f7ad4a81eba3daf65e122880b5af3adc0
ToppCell390C-Fibroblasts-Fibroblast-A_(Fibroblast_progenitors)-|390C / Donor, Lineage, Cell class and subclass (all cells)

THBS2 COMP

1.63e-0418352667d9107af17fd076ceff6b2cbcb78f892fd62d2
ToppCellTCGA-Thryoid-Primary_Tumor-Thyroid_Papillary_Carcinoma-Classical-1|TCGA-Thryoid / Sample_Type by Project: Shred V9

THBS1 THBS2

1.63e-041835206e4b05d86a7d643569e19575c2c9aa351d33f29
ToppCell390C-Fibroblasts-Fibroblast-A_(Fibroblast_progenitors)|390C / Donor, Lineage, Cell class and subclass (all cells)

THBS2 COMP

1.63e-041835228e1fc6498aaf8f42c4d6d4fa54ffff4c546d0d1
ToppCell5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

THBS2 COMP

1.63e-0418352bc7dd6a40ec9c773d005c1a46f305d40cdd0a326
ToppCellnormal_Lung-Fibroblasts-Myofibroblasts|normal_Lung / Location, Cell class and cell subclass

THBS2 COMP

1.65e-04184520b336489c10e8c3c957795dd845454f03404382b
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

LRP1B COMP

1.65e-04184528fd8bd3d28d0ee6f0ef1f14e354d8eaf63a8081b
ToppCell(2)_5-FU-(4)_COL2.3+_osteoblasts|World / Stress and Cell class

THBS1 LRP4

1.65e-0418452684d05340a3dfb8aa08b881516a37f9627a10448
ToppCellMesenchymal_cells-Chondrocytes|World / Lineage and Cell class

THBS1 COMP

1.65e-04184521e03f9f08de5ad4d45388a95afad9f23ff0d0e28
ToppCellFetal_29-31_weeks-Mesenchymal-airway_smooth_muscle_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

THBS1 THBS2

1.67e-0418552e58a009aaf342be019a909747b1895d5987d4daf
ToppCellMid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Oligo-OPC-OPC_L1-6_MYT1|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

THBS2 LRP4

1.67e-04185522e1766f1a972fecd670daaaf7eb2d3a404f121e7
ToppCell3'-Distal_airway-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

THBS2 COMP

1.67e-04185527b1c5d99bd7a6e148524029758cee244a17f5d09
ToppCell3'-Distal_airway-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

THBS2 COMP

1.67e-0418552e9033a03d574956cf3ae228740b3166e40a6397f
ToppCellMid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Oligo-OPC|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

THBS2 LRP4

1.67e-04185527aaa8335b40927e3e8fdcede807cd521fc213a0d
ToppCell3'-Distal_airway-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

THBS2 COMP

1.67e-0418552578f12c6b2e33d09598dc8e022a20c8555d1325c
ToppCellPND07-28-samps-Mesenchymal-Myofibroblast-myofibroblast_-_mature_-_C|PND07-28-samps / Age Group, Lineage, Cell class and subclass

THBS1 THBS2

1.67e-0418552427176ad9ab8d9511200fb0a132cfd1e835fe35c
ToppCellMesenchymal_cells-Osteo-CAR|World / Lineage and Cell class

LRP4 COMP

1.67e-041855216f1588893d09c864e0cb4f837a1b972a1a57baa
ToppCellTCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Non-Papillary_Muscle_Invasive_Urothelial_Carcinoma-4|TCGA-Bladder / Sample_Type by Project: Shred V9

THBS2 COMP

1.67e-0418552e1f3f0e974eb3fe1c05018beb9e124c7fb0cbe50
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.1.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

THBS1 THBS2

1.69e-04186525473283fb95cee556b1f6934cf72169b676b5bcc
ToppCellSmart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

THBS1 LRP1B

1.69e-041865223b8d51d20b05795a73892d3e20e0f9b6a207820
ComputationalGenes upregulated in subsets of cells of a given type within various tumors

THBS2 COMP

2.10e-045052GAVISH_3CA_METAPROGRAM_FIBROBLASTS_CAF_1
ComputationalGenes upregulated in subsets of cells of a given type within various tumors

THBS1 THBS2

2.10e-045052GAVISH_3CA_METAPROGRAM_FIBROBLASTS_CAF_9
ComputationalMetal / Ca ion binding.

THBS2 COMP

1.48e-0313352MODULE_324
ComputationalAdhesion molecules.

THBS2 COMP

1.66e-0314152MODULE_122
ComputationalGenes in the cancer module 105.

THBS2 COMP

3.32e-0320052MODULE_105
ComputationalECM and collagens.

THBS1 THBS2

4.18e-0322552MODULE_47
Drugdiethyl malate

THBS1 THBS2 COMP

5.17e-078653ctd:C058705
Drugmonatepil

LRP4 LRP1B

1.56e-052952CID000060810
Drug2-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide

THBS1 THBS2

1.79e-053152ctd:C577942
Drugbiphenylene

THBS1 THBS2

2.16e-053452CID000009214
DrugVal-Val

THBS1 THBS2

2.85e-053952CID000107475
DrugEpi Lovastatin

THBS1 LRP4 LRP1B

3.26e-0534153CID000003962
DrugHepII

THBS1 COMP

3.47e-054352CID003036269
DrugNC-4

THBS1 COMP

3.64e-054452CID006420119
Drug1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea

THBS1 THBS2

4.33e-054852ctd:C581572
DrugNor 3

THBS1 THBS2

4.71e-055052CID009578441
Drugsimvastatin

THBS1 LRP4 LRP1B

4.86e-0539053CID000054454
DrugGSK1210151A

THBS1 THBS2

5.09e-055252ctd:C568713
Drugsodium cholate

THBS1 LRP4 LRP1B

5.56e-0540853CID000000303
Drugchondroitin sulfate

THBS1 THBS2 COMP

5.77e-0541353CID000024766
Drugsulfite

THBS1 THBS2 LRP1B

6.87e-0543853CID000001099
DrugK00051

THBS1 THBS2

9.53e-057152CID009549278
DrugAC1L1C6C

THBS1 COMP

1.12e-047752CID000001759
Druglactofen

THBS1 THBS2

1.24e-048152CID000062276
DrugGold Sodium Thiomalate

THBS1 THBS2

1.60e-049252ctd:D006052
DrugRgds Peptide

THBS1 THBS2

2.13e-0410652CID000107775
Drugpitavastatin

LRP4 LRP1B

2.46e-0411452CID005282451
DrugChr 5

THBS1 COMP

2.96e-0412552CID006448119
Drugtrypanothione disulfide

THBS1 THBS2

3.71e-0414052CID000115098
Drugezetimibe

LRP4 LRP1B

4.09e-0414752CID000150311
Drugpyrachlostrobin

THBS1 THBS2 LRP4

4.27e-0481153ctd:C513428
Drug25-hydroxycholesterol

LRP4 LRP1B

4.84e-0416052CID000065094
Drugprobucol

LRP4 LRP1B

4.96e-0416252CID000004912
DrugFurosemide

THBS1 THBS2

5.08e-0416452ctd:D005665
DrugLycorine hydrochloride [2188-68-3]; Up 200; 12.4uM; MCF7; HT_HG-U133A

THBS1 LRP4

5.46e-04170526051_UP
Drugisocycloheximide

THBS1 LRP4 LRP1B

5.89e-0490553CID000002900
DrugAC1L1DD6

THBS2 COMP

6.05e-0417952CID000002299
DrugGabexate mesilate [56974-61-9]; Up 200; 9.6uM; HL60; HT_HG-U133A

THBS1 THBS2

6.12e-04180522937_UP
DrugPodophyllotoxin [518-28-5]; Up 200; 9.6uM; PC3; HT_HG-U133A

THBS1 LRP4

6.60e-04187525841_UP
DrugPrednisolone [50-24-8]; Up 200; 11uM; PC3; HT_HG-U133A

THBS1 LRP4

6.96e-04192525101_UP
DrugHydrocortisone base [50-23-7]; Up 200; 11uM; MCF7; HT_HG-U133A

THBS1 LRP4

7.10e-04194523284_UP
DrugFlecainide acetate [54143-56-5]; Up 200; 8.4uM; PC3; HT_HG-U133A

THBS1 LRP4

7.18e-04195524318_UP
DrugAmyleine hydrochloride [532-59-2]; Up 200; 14.8uM; MCF7; HT_HG-U133A

THBS1 THBS2

7.25e-04196524169_UP
Drug0173570-0000 [211245-44-2]; Up 200; 1uM; MCF7; HT_HG-U133A

THBS1 COMP

7.32e-04197524715_UP
DrugProchlorperazine dimaleate [84-02-6]; Up 200; 6.6uM; PC3; HT_HG-U133A

THBS2 LRP4

7.32e-04197526664_UP
DrugPropoxycaine hydrochloride [550-83-4]; Up 200; 12uM; HL60; HT_HG-U133A

THBS1 LRP4

7.32e-04197526161_UP
DrugBenfotiamine [22457-89-2]; Up 200; 8.6uM; HL60; HT_HG-U133A

THBS1 THBS2

7.32e-04197522177_UP
DrugBetahistine mesylate [54856-23-4]; Up 200; 17.2uM; HL60; HT_HG-U133A

THBS1 THBS2

7.40e-04198522472_UP
DrugSuccinylsulfathiazole [116-43-8]; Up 200; 11.2uM; MCF7; HT_HG-U133A

THBS1 COMP

7.47e-04199524847_UP
DrugS(-)Eticlopride hydrochloride [97612-24-3]; Down 200; 10.6uM; PC3; HT_HG-U133A

THBS1 COMP

7.47e-04199524634_DN
DrugParomomycin sulfate [1263-89-4]; Up 200; 5.6uM; PC3; HT_HG-U133A

THBS1 COMP

7.47e-04199524595_UP
DrugHalofantrine hydrochloride [36167-63-2]; Up 200; 7.4uM; HL60; HT_HG-U133A

THBS1 THBS2

7.55e-04200523130_UP
DrugArtemisinin [63968-64-9]; Up 200; 14.2uM; MCF7; HT_HG-U133A

THBS1 COMP

7.55e-04200527007_UP
DrugClidinium bromide [3485-62-9]; Up 200; 9.2uM; MCF7; HT_HG-U133A

THBS1 LRP4

7.55e-04200526837_UP
DrugAC1L1J6H

LRP4 LRP1B

1.05e-0323652CID000004889
DrugRgd Peptide

THBS1 THBS2

1.07e-0323952CID000104802
DrugOkadaic Acid

THBS1 THBS2

1.30e-0326352ctd:D019319
DrugMethylnitronitrosoguanidine

THBS1 THBS2

1.32e-0326552ctd:D008769
DrugCalpain inhibitor I

LRP4 LRP1B

1.47e-0328052CID000004332
Drugliu

THBS1 COMP

1.52e-0328552CID015991562
Drugsulfate

THBS1 THBS2 COMP

1.67e-03129253CID000001117
Drug17alpha-estradiol

THBS1 LRP4 LRP1B

1.71e-03130353CID000000450
DiseaseMicroangiopathy, Diabetic

THBS1 THBS2

2.75e-061652C0025945
DiseaseDiabetic Angiopathies

THBS1 THBS2

2.75e-061652C0011875
Diseaseurate measurement

THBS1 LRP4

8.65e-0389552EFO_0004531

Protein segments in the cluster

PeptideGeneStartEntry
QEDSDHDGQGDACDD

COMP

456

P49747
HDGQGDACDDDDDND

COMP

461

P49747
QFVCDHDDDCGDGSD

LRP1B

2821

Q9NZR2
CNGIDECGDNSDEDH

LRP1B

3736

Q9NZR2
GDACDHDDDNDGIPD

THBS1

891

P07996
DHDRDGQGDACDPDD

THBS2

886

P35442
CDGDNDCGDHSDEDG

LRP4

51

O75096