Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	fatty acid elongase activity	ELOVL4 ELOVL1 ELOVL3	1.43e-06	7	70	3	GO:0009922
GeneOntologyMolecularFunction	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity	CHSY1 CHSY3	7.24e-05	4	70	2	GO:0050510
GeneOntologyMolecularFunction	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity	CHSY1 CHSY3	1.80e-04	6	70	2	GO:0047238
GeneOntologyMolecularFunction	complement component C1q complex binding	C4A C4B	5.35e-04	10	70	2	GO:0001849
GeneOntologyBiologicalProcess	long-chain fatty-acyl-CoA biosynthetic process	ELOVL4 ACSL6 ELOVL1 ELOVL3	4.03e-07	19	68	4	GO:0035338
GeneOntologyBiologicalProcess	fatty acid elongation, polyunsaturated fatty acid	ELOVL4 ELOVL1 ELOVL3	1.19e-06	7	68	3	GO:0034626
GeneOntologyBiologicalProcess	fatty acid elongation, monounsaturated fatty acid	ELOVL4 ELOVL1 ELOVL3	1.19e-06	7	68	3	GO:0034625
GeneOntologyBiologicalProcess	fatty acid elongation, unsaturated fatty acid	ELOVL4 ELOVL1 ELOVL3	1.19e-06	7	68	3	GO:0019368
GeneOntologyBiologicalProcess	long-chain fatty-acyl-CoA metabolic process	ELOVL4 ACSL6 ELOVL1 ELOVL3	1.79e-06	27	68	4	GO:0035336
GeneOntologyBiologicalProcess	fatty-acyl-CoA biosynthetic process	ELOVL4 ACSL6 ELOVL1 ELOVL3	1.79e-06	27	68	4	GO:0046949
GeneOntologyBiologicalProcess	fatty acid elongation, saturated fatty acid	ELOVL4 ELOVL1 ELOVL3	1.90e-06	8	68	3	GO:0019367
GeneOntologyBiologicalProcess	sphingolipid biosynthetic process	ELOVL4 ENPP7 B3GNT5 ELOVL1 ELOVL3 ST6GALNAC4	2.41e-06	117	68	6	GO:0030148
GeneOntologyBiologicalProcess	very long-chain fatty acid metabolic process	ELOVL4 ACSL6 ELOVL1 ELOVL3	5.24e-06	35	68	4	GO:0000038
GeneOntologyBiologicalProcess	very long-chain fatty acid biosynthetic process	ELOVL4 ELOVL1 ELOVL3	9.57e-06	13	68	3	GO:0042761
GeneOntologyBiologicalProcess	fatty-acyl-CoA metabolic process	ELOVL4 ACSL6 ELOVL1 ELOVL3	1.10e-05	42	68	4	GO:0035337
GeneOntologyBiologicalProcess	membrane lipid biosynthetic process	ELOVL4 ENPP7 B3GNT5 ELOVL1 ELOVL3 ST6GALNAC4	1.31e-05	157	68	6	GO:0046467
GeneOntologyBiologicalProcess	fatty acid elongation	ELOVL4 ELOVL1 ELOVL3	1.52e-05	15	68	3	GO:0030497
GeneOntologyBiologicalProcess	acyl-CoA biosynthetic process	ELOVL4 ACSL6 ELOVL1 ELOVL3	2.05e-05	49	68	4	GO:0071616
GeneOntologyBiologicalProcess	thioester biosynthetic process	ELOVL4 ACSL6 ELOVL1 ELOVL3	2.05e-05	49	68	4	GO:0035384
GeneOntologyBiologicalProcess	amide biosynthetic process	ELOVL4 ACSL6 ENPP7 ELOVL1 ELOVL3 ST6GALNAC4	2.20e-05	172	68	6	GO:0043604
GeneOntologyBiologicalProcess	sphingolipid metabolic process	ELOVL4 ENPP7 B3GNT5 ELOVL1 ELOVL3 ST6GALNAC4	2.50e-05	176	68	6	GO:0006665
GeneOntologyBiologicalProcess	fatty acid derivative biosynthetic process	ELOVL4 ACSL6 ELOVL1 ELOVL3	2.60e-05	52	68	4	GO:1901570
GeneOntologyBiologicalProcess	sulfur compound biosynthetic process	ELOVL4 ACSL6 ELOVL1 CHSY1 ELOVL3 CHSY3	2.67e-05	178	68	6	GO:0044272
GeneOntologyBiologicalProcess	nucleoside bisphosphate biosynthetic process	ELOVL4 ACSL6 ELOVL1 ELOVL3	4.89e-05	61	68	4	GO:0033866
GeneOntologyBiologicalProcess	ribonucleoside bisphosphate biosynthetic process	ELOVL4 ACSL6 ELOVL1 ELOVL3	4.89e-05	61	68	4	GO:0034030
GeneOntologyBiologicalProcess	purine nucleoside bisphosphate biosynthetic process	ELOVL4 ACSL6 ELOVL1 ELOVL3	4.89e-05	61	68	4	GO:0034033
GeneOntologyBiologicalProcess	membrane lipid metabolic process	ELOVL4 ENPP7 B3GNT5 ELOVL1 ELOVL3 ST6GALNAC4	1.08e-04	229	68	6	GO:0006643
GeneOntologyBiologicalProcess	peptidyl-glutamic acid modification	TTLL8 AGTPBP1 TTLL7	1.18e-04	29	68	3	GO:0018200
GeneOntologyBiologicalProcess	fatty acid derivative metabolic process	ELOVL4 ACSL6 ELOVL1 ELOVL3	1.56e-04	82	68	4	GO:1901568
GeneOntologyBiologicalProcess	positive regulation of apoptotic cell clearance	C4A C4B	2.96e-04	8	68	2	GO:2000427
GeneOntologyBiologicalProcess	lipid biosynthetic process	ELOVL4 ACSL6 ENPP7 MBOAT1 B3GNT5 PSG3 FIG4 ELOVL1 ELOVL3 ST6GALNAC4	3.14e-04	813	68	10	GO:0008610
GeneOntologyBiologicalProcess	acyl-CoA metabolic process	ELOVL4 ACSL6 ELOVL1 ELOVL3	4.63e-04	109	68	4	GO:0006637
GeneOntologyBiologicalProcess	thioester metabolic process	ELOVL4 ACSL6 ELOVL1 ELOVL3	4.63e-04	109	68	4	GO:0035383
GeneOntologyBiologicalProcess	alpha-linolenic acid metabolic process	ELOVL1 ELOVL3	4.74e-04	10	68	2	GO:0036109
GeneOntologyBiologicalProcess	regulation of apoptotic cell clearance	C4A C4B	4.74e-04	10	68	2	GO:2000425
GeneOntologyBiologicalProcess	carbohydrate derivative biosynthetic process	NPC1 ELOVL4 ACSL6 B3GNT5 ELOVL1 CHSY1 ELOVL3 CHSY3 ST6GALNAC4	6.69e-04	736	68	9	GO:1901137
GeneOntologyBiologicalProcess	negative regulation of thymocyte apoptotic process	BLM RAG1	8.16e-04	13	68	2	GO:0070244
GeneOntologyBiologicalProcess	unsaturated fatty acid biosynthetic process	ELOVL4 ELOVL1 ELOVL3	8.38e-04	56	68	3	GO:0006636
GeneOntologyCellularComponent	symbiont cell surface	C4A C4B	3.06e-04	8	70	2	GO:0106139
GeneOntologyCellularComponent	other organism part	C4A C4B	3.92e-04	9	70	2	GO:0044217
Domain	ELO_CS	ELOVL4 ELOVL1 ELOVL3	9.16e-07	6	68	3	IPR030457
Domain	ELO	ELOVL4 ELOVL1 ELOVL3	1.60e-06	7	68	3	PF01151
Domain	ELO	ELOVL4 ELOVL1 ELOVL3	1.60e-06	7	68	3	PS01188
Domain	ELO_fam	ELOVL4 ELOVL1 ELOVL3	1.60e-06	7	68	3	IPR002076
Domain	Anaphylatoxin_comp_syst	C4A C4B	1.30e-04	5	68	2	IPR018081
Domain	Anaphylatoxn_comp_syst_dom	C4A C4B	1.30e-04	5	68	2	IPR001840
Domain	ANATO	C4A C4B	2.71e-04	7	68	2	SM00104
Domain	ANATO	C4A C4B	2.71e-04	7	68	2	PF01821
Domain	ANAPHYLATOXIN_2	C4A C4B	2.71e-04	7	68	2	PS01178
Domain	ANAPHYLATOXIN_1	C4A C4B	2.71e-04	7	68	2	PS01177
Domain	Anaphylatoxin/fibulin	C4A C4B	2.71e-04	7	68	2	IPR000020
Domain	DNA/RNA_helicase_DEAH_CS	BLM CHD3 DHX29	2.78e-04	35	68	3	IPR002464
Domain	DEAH_ATP_HELICASE	BLM CHD3 DHX29	3.55e-04	38	68	3	PS00690
Domain	Chond_GalNAc	CHSY1 CHSY3	3.61e-04	8	68	2	IPR008428
Domain	Thiol-ester_cl	C4A C4B	3.61e-04	8	68	2	PF10569
Domain	MacrogloblnA2_thiol-ester-bond	C4A C4B	3.61e-04	8	68	2	IPR019565
Domain	MacrogloblnA2_CS	C4A C4B	3.61e-04	8	68	2	IPR019742
Domain	CHGN	CHSY1 CHSY3	3.61e-04	8	68	2	PF05679
Domain	A2M_N	C4A C4B	5.77e-04	10	68	2	PF01835
Domain	A2M_N	C4A C4B	5.77e-04	10	68	2	IPR002890
Domain	A-macroglobulin_rcpt-bd	C4A C4B	5.77e-04	10	68	2	IPR009048
Domain	ALPHA_2_MACROGLOBULIN	C4A C4B	5.77e-04	10	68	2	PS00477
Domain	A2M	C4A C4B	5.77e-04	10	68	2	PF00207
Domain	A2M_N_2	C4A C4B	5.77e-04	10	68	2	IPR011625
Domain	A2M_comp	C4A C4B	5.77e-04	10	68	2	IPR011626
Domain	A2M_N_2	C4A C4B	5.77e-04	10	68	2	PF07703
Domain	A2M_recep	C4A C4B	5.77e-04	10	68	2	PF07677
Domain	A2M_comp	C4A C4B	5.77e-04	10	68	2	PF07678
Domain	Macroglobln_a2	C4A C4B	5.77e-04	10	68	2	IPR001599
Domain	Myosin_N	MYH1 MYH13	1.33e-03	15	68	2	PF02736
Domain	Myosin_N	MYH1 MYH13	1.33e-03	15	68	2	IPR004009
Domain	C345C	C4A C4B	1.71e-03	17	68	2	SM00643
Domain	Myosin_tail_1	MYH1 MYH13	1.92e-03	18	68	2	PF01576
Domain	Myosin_tail	MYH1 MYH13	1.92e-03	18	68	2	IPR002928
Domain	Terpenoid_cyclase/PrenylTrfase	C4A C4B	1.92e-03	18	68	2	IPR008930
Domain	NTR	C4A C4B	2.15e-03	19	68	2	PF01759
Domain	Myosin-like_IQ_dom	MYH1 MYH13	2.15e-03	19	68	2	IPR027401
Domain	-	MYH1 MYH13	2.15e-03	19	68	2	4.10.270.10
Domain	Netrin_module_non-TIMP	C4A C4B	2.15e-03	19	68	2	IPR018933
Domain	NTR	C4A C4B	3.15e-03	23	68	2	PS50189
Domain	Netrin_domain	C4A C4B	3.15e-03	23	68	2	IPR001134
Domain	TIMP-like_OB-fold	C4A C4B	4.01e-03	26	68	2	IPR008993
Domain	Helicase_C	BLM CHD3 DHX29	6.99e-03	107	68	3	PF00271
Pathway	REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS	ELOVL4 ACSL6 ELOVL1 ELOVL3	2.08e-06	24	55	4	M1016
Pathway	WP_ELONGATION_OF_VERY_LONG_CHAIN_FATTY_ACIDS	ELOVL4 ELOVL1 ELOVL3	1.21e-05	12	55	3	MM17077
Pathway	REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS	ELOVL4 ACSL6 ELOVL1 ELOVL3	1.24e-05	37	55	4	M729
Pathway	REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS	ACSL6 ELOVL1 ELOVL3	8.21e-05	22	55	3	MM15451
Pathway	REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS	ACSL6 ELOVL1 ELOVL3	2.57e-04	32	55	3	MM15446
Pathway	REACTOME_ACTIVATION_OF_C3_AND_C5	C4A C4B	3.10e-04	7	55	2	MM14685
Pathway	REACTOME_LINOLEIC_ACID_LA_METABOLISM	ELOVL1 ELOVL3	4.12e-04	8	55	2	MM14822
Pathway	REACTOME_ACTIVATION_OF_C3_AND_C5	C4A C4B	4.12e-04	8	55	2	M27031
Pathway	REACTOME_LINOLEIC_ACID_LA_METABOLISM	ELOVL1 ELOVL3	4.12e-04	8	55	2	M27115
Pathway	KEGG_MEDICUS_REFERENCE_CLASSICAL_PATHWAY_OF_COMPLEMENT_CASCADE_C4_C2_TO_C3_CONVERTASE_FORMATION	C4A C4B	4.12e-04	8	55	2	M47872
Pathway	KEGG_MEDICUS_REFERENCE_CHONDROITIN_SULFATE_BIOSYNTHESIS	CHSY1 CHSY3	4.12e-04	8	55	2	M47920
Pathway	REACTOME_CARBOXYTERMINAL_POST_TRANSLATIONAL_MODIFICATIONS_OF_TUBULIN	TTLL8 AGTPBP1 TTLL7	7.58e-04	46	55	3	M27828
Pathway	REACTOME_ALPHA_PROTEIN_KINASE_1_SIGNALING_PATHWAY	ALPK1 TAB3	8.04e-04	11	55	2	M29827
Pathway	BIOCARTA_LECTIN_PATHWAY	C4A C4B	8.04e-04	11	55	2	MM1430
Pathway	KEGG_MEDICUS_REFERENCE_LECTIN_PATHWAY_OF_COMPLEMENT_CASCADE_C4_C2_TO_C3_CONVERTASE_FORMATION	C4A C4B	8.04e-04	11	55	2	M47874
Pathway	REACTOME_ALPHA_PROTEIN_KINASE_1_SIGNALING_PATHWAY	ALPK1 TAB3	8.04e-04	11	55	2	MM15668
Pathway	BIOCARTA_CLASSIC_PATHWAY	C4A C4B	9.62e-04	12	55	2	MM1368
Pathway	REACTOME_ALPHA_LINOLENIC_OMEGA3_AND_LINOLEIC_OMEGA6_ACID_METABOLISM	ELOVL1 ELOVL3	1.13e-03	13	55	2	MM14821
Pathway	REACTOME_ALPHA_LINOLENIC_OMEGA3_AND_LINOLEIC_OMEGA6_ACID_METABOLISM	ELOVL1 ELOVL3	1.13e-03	13	55	2	M27114
Pathway	BIOCARTA_LECTIN_PATHWAY	C4A C4B	1.13e-03	13	55	2	M4732
Pathway	WP_OMEGA9_FATTY_ACID_SYNTHESIS	ELOVL1 ELOVL3	1.32e-03	14	55	2	M39780
Pathway	WP_OMEGA9_FATTY_ACID_SYNTHESIS	ELOVL1 ELOVL3	1.32e-03	14	55	2	MM15840
Pathway	KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES	ST6GALNAC4 SLC33A1	1.52e-03	15	55	2	M8535
Pathway	BIOCARTA_CLASSIC_PATHWAY	C4A C4B	1.52e-03	15	55	2	M7146
Pathway	WP_COMPLEMENT_ACTIVATION_CLASSICAL_PATHWAY	C4A C4B	1.96e-03	17	55	2	MM15944
Pathway	BIOCARTA_COMP_PATHWAY	C4A C4B	1.96e-03	17	55	2	MM1369
Pathway	REACTOME_METABOLISM_OF_LIPIDS	ELOVL4 MED24 ACSL6 ENPP7 MBOAT1 B3GNT5 FIG4 ELOVL1 ELOVL3	2.44e-03	757	55	9	M27451
Pathway	REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS	CHSY1 CHSY3	2.45e-03	19	55	2	MM14800
Pathway	KEGG_COMPLEMENT_AND_COAGULATION_CASCADES	C4A C4B F5	2.45e-03	69	55	3	M16894
Pathway	BIOCARTA_COMP_PATHWAY	C4A C4B	2.71e-03	20	55	2	M917
Pathway	REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS	CHSY1 CHSY3	2.71e-03	20	55	2	M658
Pubmed	Enhanced transcription of complement and coagulation genes in the absence of adaptive immunity.	RAG1 C4A C4B	8.15e-09	3	71	3	19200601
Pubmed	Innate response to self-antigen significantly exacerbates burn wound depth.	RAG1 C4A C4B	8.15e-09	3	71	3	17360462
Pubmed	Intestinal reperfusion injury is mediated by IgM and complement.	RAG1 C4A C4B	3.26e-08	4	71	3	10066708
Pubmed	A platelet-mediated system for shuttling blood-borne bacteria to CD8α+ dendritic cells depends on glycoprotein GPIb and complement C3.	RAG1 C4A C4B	2.84e-07	7	71	3	22037602
Pubmed	Biosynthesis of triacylglycerols.	ELOVL4 ACSL6 ELOVL1 ELOVL3	3.15e-07	28	71	4	8944226
Pubmed	ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis.	ELOVL4 ELOVL1 ELOVL3	9.68e-07	10	71	3	20937905
Pubmed	Impaired epidermal permeability barrier in mice lacking elovl1, the gene responsible for very-long-chain fatty acid production.	ELOVL4 ELOVL1 ELOVL3	1.33e-06	11	71	3	23689133
Pubmed	Copy number analysis of complement C4A, C4B and C4A silencing mutation by real-time quantitative polymerase chain reaction.	C4A C4B	4.11e-06	2	71	2	22737222
Pubmed	Deficiency of C4 from donor or recipient mouse fails to prevent renal allograft rejection.	C4A C4B	4.11e-06	2	71	2	16565498
Pubmed	Complete deficiencies of complement C4A and C4B including 2-bp insertion in codon 1213 are genetic risk factors of systemic lupus erythematosus in Thai populations.	C4A C4B	4.11e-06	2	71	2	15998580
Pubmed	Structural polymorphism of murine C4 and its linkage to H-2.	C4A C4B	4.11e-06	2	71	2	7373044
Pubmed	High-throughput analysis of the C4 polymorphism by a combination of MLPA and isotype-specific ELISA's.	C4A C4B	4.11e-06	2	71	2	19062096
Pubmed	The chemical structure of the C4d fragment of the human complement component C4.	C4A C4B	4.11e-06	2	71	2	3696167
Pubmed	Restriction fragment length polymorphism of the murine C4 and Slp genes: two C4 groups.	C4A C4B	4.11e-06	2	71	2	1357031
Pubmed	Structural comparison of human C4A3 and C4B1 after proteolytic activation by C1s.	C4A C4B	4.11e-06	2	71	2	16098595
Pubmed	Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice.	C4A C4B	4.11e-06	2	71	2	19933335
Pubmed	Structural basis for the C4d.1/C4d.2 serologic allotypes of murine complement component C4.	C4A C4B	4.11e-06	2	71	2	2459207
Pubmed	Antigen-induced B cell apoptosis is independent of complement C4.	C4A C4B	4.11e-06	2	71	2	17645767
Pubmed	Increased frequency of C4B*Q0 alleles in patients with Henoch-Schönlein purpura.	C4A C4B	4.11e-06	2	71	2	15787745
Pubmed	Anti-DNA autoreactivity in C4-deficient mice.	C4A C4B	4.11e-06	2	71	2	12207352
Pubmed	Neuropil contraction in relation to Complement C4 gene copy numbers in independent cohorts of adolescent-onset and young adult-onset schizophrenia patients-a pilot study.	C4A C4B	4.11e-06	2	71	2	30026462
Pubmed	A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor B.	C4A C4B	4.11e-06	2	71	2	6559257
Pubmed	Complement C4A and C4B Gene Copy Number Study in Alzheimer's Disease Patients.	C4A C4B	4.11e-06	2	71	2	27758680
Pubmed	Genetically determined partial complement C4 deficiency states are not independent risk factors for SLE in UK and Spanish populations.	C4A C4B	4.11e-06	2	71	2	22387014
Pubmed	Complement C4 Is Reduced in iPSC-Derived Astrocytes of Autism Spectrum Disorder Subjects.	C4A C4B	4.11e-06	2	71	2	34299197
Pubmed	Assessment of complement C4 gene copy number using the paralog ratio test.	C4A C4B	4.11e-06	2	71	2	20506482
Pubmed	Polymerase chain reaction based C4AQ0 and C4BQ0 genotyping: association with systemic lupus erythematosus in southwest Han Chinese.	C4A C4B	4.11e-06	2	71	2	12480675
Pubmed	Low C4, C4A and C4B gene copy numbers are stronger risk factors for juvenile-onset than for adult-onset systemic lupus erythematosus.	C4A C4B	4.11e-06	2	71	2	26800705
Pubmed	Complement C4 maintains peripheral B-cell tolerance in a myeloid cell dependent manner.	C4A C4B	4.11e-06	2	71	2	23749435
Pubmed	Copy number variations of complement component C4 are associated with Behçet's disease but not with ankylosing spondylitis associated with acute anterior uveitis.	C4A C4B	4.11e-06	2	71	2	23918728
Pubmed	Murine complement C4 is not required for experimental autoimmune encephalomyelitis.	C4A C4B	4.11e-06	2	71	2	15390104
Pubmed	Molecular genetics of androgen-dependent and -independent expression of mouse sex-limited protein.	C4A C4B	4.11e-06	2	71	2	3037333
Pubmed	Enhanced expression of matrix metalloproteinase-12 contributes to Npc1 deficiency-induced axonal degeneration.	NPC1 MMP12	4.11e-06	2	71	2	25864931
Pubmed	Evidence of a role for C4 in modulating interstitial inflammation in experimental glomerulonephritis.	C4A C4B	4.11e-06	2	71	2	11726230
Pubmed	Quantitative variations in the expression of the mouse serum antigen Ss and its sex-limited allotype Slp.	C4A C4B	4.11e-06	2	71	2	4216347
Pubmed	Importance of the alpha 3-fragment of complement C4 for the binding with C4b-binding protein.	C4A C4B	4.11e-06	2	71	2	1699796
Pubmed	Sequence determination of the thiolester site of the fourth component of human complement.	C4A C4B	4.11e-06	2	71	2	6950384
Pubmed	Molecular cloning and characterization of complementary and genomic DNA clones for mouse C4 and Slp.	C4A C4B	4.11e-06	2	71	2	2997024
Pubmed	Visual demonstration of the organization of the human complement C4 and 21-hydroxylase genes by high-resolution fluorescence in situ hybridization.	C4A C4B	4.11e-06	2	71	2	8660986
Pubmed	Constitutive expression of Slp genes in mouse strain B10.WR directed by C4 regulatory sequences.	C4A C4B	4.11e-06	2	71	2	3624865
Pubmed	Tissue-specific RNA processing for the complement C4 gene transcript in the H-2k mouse strain.	C4A C4B	4.11e-06	2	71	2	8428773
Pubmed	Determination of the loss of function complement C4 exon 29 CT insertion using a novel paralog-specific assay in healthy UK and Spanish populations.	C4A C4B	4.11e-06	2	71	2	21857912
Pubmed	Complement C4 deficiency--a plausible risk factor for non-tuberculous mycobacteria (NTM) infection in apparently immunocompetent patients.	C4A C4B	4.11e-06	2	71	2	24638111
Pubmed	Isolation of cDNA clones specifying the fourth component of mouse complement and its isotype, sex-limited protein.	C4A C4B	4.11e-06	2	71	2	6208559
Pubmed	The role of the histocompatibility-2-linked Ss-Slp region in the control of mouse complement.	C4A C4B	4.11e-06	2	71	2	4514997
Pubmed	Transcriptional repression of C4 complement by hepatitis C virus proteins.	C4A C4B	4.11e-06	2	71	2	21345967
Pubmed	The inheritance of susceptibility to the Gross leukemia virus in mice.	C4A C4B	4.11e-06	2	71	2	5919331
Pubmed	An ancient provirus has imposed androgen regulation on the adjacent mouse sex-limited protein gene.	C4A C4B	4.11e-06	2	71	2	3167981
Pubmed	The dichotomous size variation of human complement C4 genes is mediated by a novel family of endogenous retroviruses, which also establishes species-specific genomic patterns among Old World primates.	C4A C4B	4.11e-06	2	71	2	7545960
Pubmed	Insights on the relationship between complement component C4 serum concentrations and C4 gene copy numbers in a Western Australian systemic lupus erythematosus cohort.	C4A C4B	4.11e-06	2	71	2	30041577
Pubmed	Restriction fragment analysis of H-2 recombinant mouse strains with crossovers between E alpha and C4 genes.	C4A C4B	4.11e-06	2	71	2	2572548
Pubmed	The complement component C4 of mammals.	C4A C4B	4.11e-06	2	71	2	2302180
Pubmed	Complete cDNA sequence of the fourth component of murine complement.	C4A C4B	4.11e-06	2	71	2	3862104
Pubmed	The BS variant of C4 protects against age-related loss of white matter microstructural integrity.	C4A C4B	4.11e-06	2	71	2	34358307
Pubmed	Acute renal allograft rejection: diagnostic significance of focal peritubular capillary C4d.	C4A C4B	4.11e-06	2	71	2	18360261
Pubmed	Gene CNVs and protein levels of complement C4A and C4B as novel biomarkers for partial disease remissions in new-onset type 1 diabetes patients.	C4A C4B	4.11e-06	2	71	2	22151770
Pubmed	C4d-positive chronic rejection: a frequent entity with a poor outcome.	C4A C4B	4.11e-06	2	71	2	18091514
Pubmed	Comprehensive approach to study complement C4 in systemic lupus erythematosus: Gene polymorphisms, protein levels and functional activity.	C4A C4B	4.11e-06	2	71	2	29080553
Pubmed	Schizophrenia risk from complex variation of complement component 4.	C4A C4B	4.11e-06	2	71	2	26814963
Pubmed	Genes for murine fourth complement component (C4) and sex-limited protein (Slp) identified by hybridization to C4- and Slp-specific cDNA.	C4A C4B	4.11e-06	2	71	2	6589636
Pubmed	C4 Deficiency is a predisposing factor for Streptococcus pneumoniae-induced autoantibody production.	C4A C4B	4.11e-06	2	71	2	25339671
Pubmed	A study of association of the complement C4 mutations with systemic lupus erythematosus in the Malaysian population.	C4A C4B	4.11e-06	2	71	2	17728371
Pubmed	Structure and organization of the C4 genes.	C4A C4B	4.11e-06	2	71	2	6149580
Pubmed	Sequence heterogeneity of murine complementary DNA clones related to the C4 and C4-Slp isoforms of the fourth complement component.	C4A C4B	4.11e-06	2	71	2	6149581
Pubmed	The follicular dendritic cell restricted epitope, FDC-M2, is complement C4; localization of immune complexes in mouse tissues.	C4A C4B	4.11e-06	2	71	2	12115608
Pubmed	Biochemistry and biology of anaphylatoxins.	C4A C4B	4.11e-06	2	71	2	3542363
Pubmed	C4 from C4-high and C4-low mouse strains have identical sequences in the region corresponding to the isotype-specific segment of human C4.	C4A C4B	4.11e-06	2	71	2	2387317
Pubmed	Promoter elements of the mouse complement C4 gene critical for transcription activation and start site location.	C4A C4B	4.11e-06	2	71	2	8132550
Pubmed	Substitution of a single amino acid (aspartic acid for histidine) converts the functional activity of human complement C4B to C4A.	C4A C4B	4.11e-06	2	71	2	2395880
Pubmed	Effects of Complement C4 Gene Copy Number Variations, Size Dichotomy, and C4A Deficiency on Genetic Risk and Clinical Presentation of Systemic Lupus Erythematosus in East Asian Populations.	C4A C4B	4.11e-06	2	71	2	26814708
Pubmed	cDNA clone spanning the alpha-gamma subunit junction in the precursor of the murine fourth complement component (C4).	C4A C4B	4.11e-06	2	71	2	6192448
Pubmed	Complete primary structure of human C4a anaphylatoxin.	C4A C4B	4.11e-06	2	71	2	6167582
Pubmed	Identification of the size and antigenic determinants of the human C4 gene by a polymerase chain-reaction-based amplification method.	C4A C4B	4.11e-06	2	71	2	16908004
Pubmed	Slp is an essential component of an EDTA-resistant activation pathway of mouse complement.	C4A C4B	4.11e-06	2	71	2	1438267
Pubmed	Structural studies on the murine fourth component of complement (C4). IV. Demonstration that C4 and Slp are encoded by separate loci.	C4A C4B	4.11e-06	2	71	2	7365238
Pubmed	Genetic deficiency of complement isoforms C4A or C4B predicts improved survival of metastatic renal cell carcinoma.	C4A C4B	4.11e-06	2	71	2	19150565
Pubmed	Chondroitin sulfate synthase-3. Molecular cloning and characterization.	CHSY1 CHSY3	4.11e-06	2	71	2	12907687
Pubmed	Interaction between the labile binding sites of the fourth (C4) and fifth (C5) human complement proteins and erythrocyte cell membranes.	C4A C4B	4.11e-06	2	71	2	7391573
Pubmed	Elevated levels of endogenous apoptotic DNA and IFN-alpha in complement C4-deficient mice: implications for induction of systemic lupus erythematosus.	C4A C4B	4.11e-06	2	71	2	17506029
Pubmed	Peritubular capillary C4d deposition in lupus nephritis different from antibody-mediated renal rejection.	C4A C4B	4.11e-06	2	71	2	17971360
Pubmed	Low C4 gene copy numbers are associated with superior graft survival in patients transplanted with a deceased donor kidney.	C4A C4B	4.11e-06	2	71	2	23715124
Pubmed	Identification of the 5'-flanking regulatory region responsible for the difference in transcriptional control between mouse complement C4 and Slp genes.	C4A C4B	4.11e-06	2	71	2	3464002
Pubmed	Complete nucleotide and derived amino acid sequences of the fourth component of mouse complement (C4). Evolutionary aspects.	C4A C4B	4.11e-06	2	71	2	2993295
Pubmed	Clinical features of patients with homozygous complement C4A or C4B deficiency.	C4A C4B	4.11e-06	2	71	2	29928053
Pubmed	Analysis of C4 and the C4 binding protein in the MRL/lpr mouse.	C4A C4B	4.11e-06	2	71	2	17971229
Pubmed	Genetic deficiency of C4 presenting with recurrent infections and a SLE-like disease. Genetic and immunologic studies.	C4A C4B	4.11e-06	2	71	2	6881182
Pubmed	Identification of the site of sulfation of the fourth component of human complement.	C4A C4B	4.11e-06	2	71	2	3944109
Pubmed	Partial C4 deficiency in juvenile idiopathic arthritis patients.	C4A C4B	4.11e-06	2	71	2	17921792
Pubmed	Complement activation and complement receptors on follicular dendritic cells are critical for the function of a targeted adjuvant.	C4A C4B	4.11e-06	2	71	2	21880985
Pubmed	Amino acid sequence around the thiol and reactive acyl groups of human complement component C4.	C4A C4B	4.11e-06	2	71	2	6978711
Pubmed	Plasma Complement 3 and Complement 4 Are Promising Biomarkers for Distinguishing NMOSD From MOGAD and Are Associated With the Blood-Brain-Barrier Disruption in NMOSD.	C4A C4B	4.11e-06	2	71	2	35898513
Pubmed	Overexpression of schizophrenia susceptibility factor human complement C4A promotes excessive synaptic loss and behavioral changes in mice.	C4A C4B	4.11e-06	2	71	2	33353966
Pubmed	Sequence comparison of alleles of the fourth component of complement (C4) and sex-limited protein (Slp).	C4A C4B	4.11e-06	2	71	2	3008092
Pubmed	Borrelia burgdorferi outer surface protein C (OspC) binds complement component C4b and confers bloodstream survival.	C4A C4B	4.11e-06	2	71	2	28873507
Pubmed	The molecular basis for the difference in immune hemolysis activity of the Chido and Rodgers isotypes of human complement component C4.	C4A C4B	4.11e-06	2	71	2	6609966
Pubmed	Heterogeneity and linkage of equine C4 and steroid 21-hydroxylase genes.	C4A C4B	4.11e-06	2	71	2	2900855
Pubmed	Studies on the murine Ss protein: demonstration that the Ss protein is functionally the fourth component of complement.	C4A C4B	4.11e-06	2	71	2	276882
Pubmed	Amino acid sequence of a polymorphic segment from fragment C4d of human complement component C4.	C4A C4B	4.11e-06	2	71	2	6832377
Pubmed	Recombination of two homologous MHC class III genes of the mouse (C4 and Slp) that accounts for the loss of testosterone dependence of sex-limited protein expression.	C4A C4B	4.11e-06	2	71	2	3794341
Pubmed	Complement and c4 null alleles in severe chronic adult periodontitis.	C4A C4B	4.11e-06	2	71	2	17257223
GeneFamily	Beta 3-glycosyltransferases	B3GNT5 CHSY1 CHSY3	3.42e-05	24	48	3	426
GeneFamily	Glycosyltransferase family 6\|Blood group antigens	GYPC C4A C4B	1.28e-04	37	48	3	454
GeneFamily	C3 and PZP like, alpha-2-macroglobulin domain containing	C4A C4B	2.46e-04	9	48	2	1234
GeneFamily	Tubulin tyrosine ligase family	TTLL8 TTLL7	6.15e-04	14	48	2	779
GeneFamily	Myosin heavy chains	MYH1 MYH13	7.09e-04	15	48	2	1098
GeneFamily	Beta 4-glycosyltransferases	CHSY1 CHSY3	9.15e-04	17	48	2	425
GeneFamily	Complement system\|Sushi domain containing	C4A C4B	4.10e-03	36	48	2	492
ToppCell	mild-pDC\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	PLXNA4 ST6GALNAC4 TTC39A UNC93B1 LRRK1 DAAM1	7.38e-07	197	71	6	0cb00daa6943f7a7fb34a8fdf51188646af65686
ToppCell	systemic_lupus_erythematosus-treated-Myeloid-plasmacytoid_dendritic_cell-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	NPC1 PLXNA4 ST6GALNAC4 TTC39A UNC93B1	1.08e-05	182	71	5	9bbe8062aa562dc3b9c299581faf6ebbcb72a9f7
ToppCell	systemic_lupus_erythematosus-treated-Myeloid-plasmacytoid_dendritic_cell\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	NPC1 PLXNA4 ST6GALNAC4 TTC39A UNC93B1	1.08e-05	182	71	5	4602a98df7045e2c70b7560abfba9b444fbd5d30
ToppCell	CV-Moderate-7\|Moderate / Virus stimulation, Condition and Cluster	NPC1 URB1 RNF213 ERMP1 AGTPBP1	1.16e-05	185	71	5	a6c9203ce6c2892a4a369c9bcfb85720f01cbb3f
ToppCell	CV-Moderate-7\|CV / Virus stimulation, Condition and Cluster	NPC1 URB1 RNF213 ERMP1 AGTPBP1	1.19e-05	186	71	5	8571956890fc9894d766ba294a28e376b4aba428
ToppCell	Control-Lymphoid-B_Plasma\|Lymphoid / Disease state, Lineage and Cell class	FNDC3B C4B ST6GALNAC4 LRRK1 TTLL7	1.19e-05	186	71	5	a08a50bff4e629588faa22440d57334b1df0e8df
ToppCell	COVID-19_Severe-pDC\|COVID-19_Severe / disease group, cell group and cell class	NPC1 PLXNA4 ST6GALNAC4 TTC39A UNC93B1	1.32e-05	190	71	5	c5ab6b7492fb86aff3d2af3eb671c9f985ae4aeb
ToppCell	Healthy-pDC\|World / disease group, cell group and cell class	NPC1 PLXNA4 ST6GALNAC4 TTC39A UNC93B1	1.36e-05	191	71	5	6e1d825dc33b915b95f13ccd237a552160a4be98
ToppCell	Healthy-pDC\|Healthy / disease group, cell group and cell class	NPC1 PLXNA4 ST6GALNAC4 TTC39A UNC93B1	1.39e-05	192	71	5	33d695a28d22b4af111df9591830a33bb7ef7b2d
ToppCell	VE-pDC-\|VE / Condition, Cell_class and T cell subcluster	NPC1 PLXNA4 ST6GALNAC4 TTC39A LRRK1	1.43e-05	193	71	5	583724de588fcde3aeda056138c522dc0225a387
ToppCell	control-pDC\|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	NPC1 PLXNA4 ST6GALNAC4 TTC39A UNC93B1	1.43e-05	193	71	5	30a6559c9a9e8941861cb259b4836acccc427e68
ToppCell	VE-pDC\|VE / Condition, Cell_class and T cell subcluster	NPC1 PLXNA4 ST6GALNAC4 TTC39A LRRK1	1.43e-05	193	71	5	bb759dc9ef0ec41d655002f59021d62d62d44289
ToppCell	COVID-19-COVID-19_Mild-Myeloid-pDC\|COVID-19_Mild / Disease, condition lineage and cell class	NPC1 PLXNA4 ST6GALNAC4 UNC93B1 DAAM1	1.65e-05	199	71	5	9de61e5189d907cc969ac3043d68204f70acc0bf
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Myeloid-Dendritic-plasmacytoid_dendritic_cell-DC_c4-LILRA4\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	BLM PRMT8 PLXNA4 PATE2	8.06e-05	143	71	4	d0ed8c25da1327085e042c2e03cb7503e2c52ce0
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Myeloid-Dendritic-plasmacytoid_dendritic_cell\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	BLM PRMT8 PLXNA4 PATE2	8.06e-05	143	71	4	8900b92a24289204b9ec7baccc11594fec7694f1
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Degenerative_Ascending_Thin_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PRMT8 MYH13 PLXNA4 LIX1	8.28e-05	144	71	4	163c591fedad2beb7f92531e6240e9554f90ea40
ToppCell	IIH-CD8-proli_CD4\|IIH / Condition, Cell_class and T cell subcluster	TUBGCP6 GET4 PDE6A DHX29	8.73e-05	146	71	4	7fa6e35def3f7cffbee1e1c2f10b523bab678e14
ToppCell	droplet-Lung-18m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell-CD8-positive,_alpha-beta_T_cell_l21\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	BLM CENPC CHD3 CHAMP1	9.45e-05	149	71	4	65778f19599b4955c0a16f0121237656449431fb
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_II-Z\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PDE6A B3GNT5 UNC93B1 DENND11	9.69e-05	150	71	4	6c39e73a0b05d4b26589f333ce13924e3d373b8d
ToppCell	368C-Myeloid-Monocyte-CD16+_Monocyte\|368C / Donor, Lineage, Cell class and subclass (all cells)	PRMT8 USP9Y DENND11 SMCR8	1.13e-04	156	71	4	25b0936960be4955b6a6d6b8a867fdd4be548f05
ToppCell	368C-Myeloid-Macrophage-FABP4+_Macrophage_2\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	PLXNA4 CHSY3 LIX1 TTLL7	1.40e-04	165	71	4	3d2acdae0dd2b79a15f74158e8e566ce22b4218e
ToppCell	facs-Heart-RA-18m-Lymphocytic-B_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RAG1 MYH13 B3GNT5 ARID3B	1.43e-04	166	71	4	fc2cf67311c86fda75b35fcd4768b6f6f14c59d0
ToppCell	facs-Heart-RA-18m-Lymphocytic-B_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RAG1 MYH13 B3GNT5 ARID3B	1.43e-04	166	71	4	33a6876d06e26176135a73a77c19e634ec53f7ce
ToppCell	COVID_vent-Lymphocytic-Dendritic-pDC\|COVID_vent / Disease condition, Lineage, Cell class and subclass	NPC1 PLXNA4 TTC39A LRRK1	1.60e-04	171	71	4	779c951d274ecbd1d546ac425d6c8e718623be5a
ToppCell	COVID_vent-Lymphocytic-Dendritic\|COVID_vent / Disease condition, Lineage, Cell class and subclass	NPC1 PLXNA4 TTC39A LRRK1	1.60e-04	171	71	4	debbb071d260639b16269c94d172766908325c58
ToppCell	wk_15-18-Hematologic-Myeloid-pDC\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	NPC1 ST6GALNAC4 TTC39A UNC93B1	1.68e-04	173	71	4	b571970e3ba88afc07041c5692ccfd85fc39e796
ToppCell	normal_Lymph_Node-B_lymphocytes-GrB-secreting_B_cells\|normal_Lymph_Node / Location, Cell class and cell subclass	RAG1 PLXNA4 UNC93B1 LRRK1	1.75e-04	175	71	4	29fbdfe1d3bfcb063be2bced0128a33176c5b78f
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Ascending_Thin_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FNDC3B PLXNA4 ERMP1 LIX1	1.91e-04	179	71	4	55bc69f107fc710db7617c428575792adfdbbcc1
ToppCell	wk_20-22-Hematologic-Myeloid-pDC\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	NPC1 TTC39A UNC93B1 LRRK1	1.99e-04	181	71	4	60607c5ff6d5b1cb416adc034491dca31c41e988
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FNDC3B PLXNA4 ERMP1 LIX1	2.08e-04	183	71	4	83592c332b1e82673f993d37c7f480befdc3dcda
ToppCell	10x5'-bone_marrow-Myeloid_Dendritic-pDC\|bone_marrow / Manually curated celltypes from each tissue	PLXNA4 ST6GALNAC4 TTC39A UNC93B1	2.12e-04	184	71	4	2817d530863e85dfdcd143b7a3dc5fc58a9cd98b
ToppCell	(7)_MNP-(7)_DC_plasmacytoid\|(7)_MNP / Spleen cell shreds - cell class (v1) and cell subclass (v1)	PLXNA4 ST6GALNAC4 TTC39A DAAM1	2.17e-04	185	71	4	9f67f652488e17075a372e2a2e1100f6d0af6d7d
ToppCell	facs-Large_Intestine-Distal-24m-Epithelial\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	B3GNT5 ST6GALNAC4 TTC39A LIX1	2.17e-04	185	71	4	e29079ef09aee62c3e9756341db4e59ca9dbf7ac
ToppCell	facs-Large_Intestine-Distal-24m\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	B3GNT5 ST6GALNAC4 TTC39A LIX1	2.17e-04	185	71	4	2ecc4b76b3645b65c226c2298bff307cc6479172
ToppCell	healthy_donor-Lymphocytic-Dendritic\|healthy_donor / Disease condition, Lineage, Cell class and subclass	PLXNA4 ST6GALNAC4 TTC39A UNC93B1	2.21e-04	186	71	4	916f2aeea4989ba7a29e071e348a51010f010223
ToppCell	control-Myeloid-pDC\|control / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	NPC1 PLXNA4 ST6GALNAC4 TTC39A	2.21e-04	186	71	4	fe31e9cf4575ee40b50489593c51d8c36c3cc532
ToppCell	PBMC-Severe-Myeloid-pDC-pDC\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PLXNA4 ST6GALNAC4 TTC39A UNC93B1	2.21e-04	186	71	4	b70cd94c651b56dcf2e55554533a5f1130845390
ToppCell	PBMC-Severe-Myeloid-pDC-pDC-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PLXNA4 ST6GALNAC4 TTC39A UNC93B1	2.21e-04	186	71	4	31df1eafa3010bc1be6fc4d4689f1393d69b6b13
ToppCell	control-Myeloid-pDC\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	NPC1 PLXNA4 ST6GALNAC4 TTC39A	2.21e-04	186	71	4	fccee4cfcc887358cf916d974f29627095b5ad9c
ToppCell	systemic_lupus_erythematosus-flare-Myeloid-plasmacytoid_dendritic_cell-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	PLXNA4 ST6GALNAC4 TTC39A UNC93B1	2.21e-04	186	71	4	a07694caf7fede06a47636725bcc7f09909cdf07
ToppCell	PBMC-Severe-Myeloid-pDC\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PLXNA4 ST6GALNAC4 TTC39A UNC93B1	2.21e-04	186	71	4	eaa431ccd4cdd36fe06a44987603ec9979025aa8
ToppCell	COVID-19_Severe-Myeloid-pDC\|COVID-19_Severe / Disease group, lineage and cell class	PLXNA4 ST6GALNAC4 TTC39A UNC93B1	2.21e-04	186	71	4	3db5ed69d49e5d79f990aca0295ddce4c297a05c
ToppCell	PBMC-Severe-Myeloid-pDC\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	PLXNA4 ST6GALNAC4 TTC39A UNC93B1	2.21e-04	186	71	4	b95be984e308d4f9061274a35995ec558d434e74
ToppCell	PBMC-Severe-Myeloid-pDC-pDC-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	PLXNA4 ST6GALNAC4 TTC39A UNC93B1	2.21e-04	186	71	4	8f7949740286f64e034d1eb533ebc2c6f71ae966
ToppCell	healthy_donor-Lymphocytic-Dendritic-pDC\|healthy_donor / Disease condition, Lineage, Cell class and subclass	PLXNA4 ST6GALNAC4 TTC39A UNC93B1	2.21e-04	186	71	4	45f66619e45d590c7365a51782d4ac46b7d31fde
ToppCell	PBMC-Severe-Myeloid-pDC-pDC\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	PLXNA4 ST6GALNAC4 TTC39A UNC93B1	2.21e-04	186	71	4	95c7318e521fb6aa02e244b1e81e6b2a62107756
ToppCell	(0)_Myeloid-(01)_Dendritic_cell-(011)_pDC\|(01)_Dendritic_cell / immune cells in Peripheral Blood (logTPM normalization)	NPC1 PLXNA4 ST6GALNAC4 TTC39A	2.26e-04	187	71	4	068502efa3f0ac4cea2fa4a18d1c2f686a4fba54
ToppCell	facs-Large_Intestine-Distal-18m\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	B3GNT5 ST6GALNAC4 TTC39A LIX1	2.26e-04	187	71	4	a4c408fc941d2e8a811a26aa916c0b3e3341163a
ToppCell	facs-Large_Intestine-Distal-18m-Epithelial\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	B3GNT5 ST6GALNAC4 TTC39A LIX1	2.26e-04	187	71	4	ab109aa51beae3df474c15002e70361f328cadad
ToppCell	Leuk-UTI-Myeloid-pDC\|Leuk-UTI / Disease, Lineage and Cell Type	PLXNA4 ST6GALNAC4 TTC39A DAAM1	2.26e-04	187	71	4	e3035b1f65ab12b8f01799b8e5d6633b9b584a06
ToppCell	control-pDC\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	PLXNA4 ST6GALNAC4 TTC39A UNC93B1	2.26e-04	187	71	4	c78aee98b32719aa45811b620fc97be1ecf5fd53
ToppCell	(0)_Myeloid-(011)_pDC\|(0)_Myeloid / immune cells in Peripheral Blood (logTPM normalization)	NPC1 PLXNA4 ST6GALNAC4 TTC39A	2.31e-04	188	71	4	a81b5d840490d6a636fe168f8cff2c4984369f09
ToppCell	PBMC-Mild-Myeloid-pDC\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	PLXNA4 ST6GALNAC4 TTC39A UNC93B1	2.31e-04	188	71	4	de6a270b6e4fe09c39a52c296632d86ada98465b
ToppCell	PBMC-Mild-Myeloid-pDC-pDC\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	PLXNA4 ST6GALNAC4 TTC39A UNC93B1	2.31e-04	188	71	4	89411c4db3df5e1dc36cf8af4ffcc0abbecbe4df
ToppCell	COVID-19_Severe-pDC\|World / disease group, cell group and cell class	PLXNA4 ST6GALNAC4 TTC39A UNC93B1	2.31e-04	188	71	4	4c8e328b8206120708b05ea3c5865a0200dc5c4e
ToppCell	PBMC-Mild-Myeloid-pDC-pDC-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	PLXNA4 ST6GALNAC4 TTC39A UNC93B1	2.31e-04	188	71	4	879054b780378ae05be68e597c77c931bf0ade03
ToppCell	systemic_lupus_erythematosus-flare-Myeloid-plasmacytoid_dendritic_cell\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	PLXNA4 ST6GALNAC4 TTC39A UNC93B1	2.31e-04	188	71	4	26405ef1b934744e672c642db78834c21d3ba28f
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FNDC3B RNF213 DNAH5 LIX1	2.35e-04	189	71	4	aadb7a2de4cbe7f0958651f2739bba430b93f5c1
ToppCell	PBMC-Mild-Myeloid-pDC\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PLXNA4 ST6GALNAC4 TTC39A UNC93B1	2.35e-04	189	71	4	209cae68d78c8f72479b169e27c3ff7e143adece
ToppCell	3'_v3-lymph-node_spleen-Myeloid_Dendritic-pDC\|lymph-node_spleen / Manually curated celltypes from each tissue	PLXNA4 ST6GALNAC4 TTC39A UNC93B1	2.35e-04	189	71	4	6c2ace61a7d62bcf7e76b73e2da8b722d03e713b
ToppCell	PBMC-Mild-Myeloid-pDC-pDC-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PLXNA4 ST6GALNAC4 TTC39A UNC93B1	2.35e-04	189	71	4	a9ad1fb12304541f909dd0eeac9b9eb28c31fd41
ToppCell	COVID-19_Mild-Myeloid-pDC\|COVID-19_Mild / Disease group, lineage and cell class	PLXNA4 ST6GALNAC4 TTC39A UNC93B1	2.35e-04	189	71	4	c6cfd6aa21c19f2c62d80218bbc924e14e82aada
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FNDC3B RNF213 DNAH5 LIX1	2.35e-04	189	71	4	8977f3295b7df7c7474b3f371de90a82ae4bb50c
ToppCell	Control-Myeloid-pDC\|Control / Disease group, lineage and cell class	PLXNA4 ST6GALNAC4 TTC39A UNC93B1	2.35e-04	189	71	4	46770b99da42f11f10cfc67cea8562342d60b867
ToppCell	PBMC-Mild-Myeloid-pDC-pDC\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PLXNA4 ST6GALNAC4 TTC39A UNC93B1	2.35e-04	189	71	4	98ca646231fbd5f29827c2dd31ac4503026bad7d
ToppCell	3'_v3-bone_marrow-Myeloid_Dendritic-pDC\|bone_marrow / Manually curated celltypes from each tissue	PLXNA4 ST6GALNAC4 TTC39A UNC93B1	2.40e-04	190	71	4	dde0e34f6a06cdbbb65c86472360c09f0279a572
ToppCell	facs-Large_Intestine-Distal\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	B3GNT5 ST6GALNAC4 TTC39A LIX1	2.40e-04	190	71	4	3964a8390522b61b73235151bb0a2ff36b856867
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Ascending_Thin_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FNDC3B PLXNA4 ERMP1 LIX1	2.40e-04	190	71	4	59bbbd2c8d4b7ce46c54ca8022b1557e7e5eee2a
ToppCell	COVID-19_Moderate-pDC\|World / disease group, cell group and cell class	NPC1 ST6GALNAC4 TTC39A UNC93B1	2.45e-04	191	71	4	93adfbc0b22f6006d6d5ad67a99e33cbe9e1dfe9
ToppCell	Control-pDC-\|Control / Disease condition and Cell class	NPC1 PLXNA4 ST6GALNAC4 TTC39A	2.45e-04	191	71	4	1d7b0fae4d114d6db933c18b4eb2066ffa61356d
ToppCell	systemic_lupus_erythematosus-managed-Myeloid-plasmacytoid_dendritic_cell\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	PLXNA4 ST6GALNAC4 TTC39A UNC93B1	2.45e-04	191	71	4	8c487704cbbb5eeff54e8c6fb6fffa1472b5351f
ToppCell	Control-pDC\|Control / Disease condition and Cell class	NPC1 PLXNA4 ST6GALNAC4 TTC39A	2.45e-04	191	71	4	543e1437a52d04436862dd1c27b4fae95c44fcc8
ToppCell	COVID-19_Moderate-pDC\|COVID-19_Moderate / disease group, cell group and cell class	NPC1 ST6GALNAC4 TTC39A UNC93B1	2.45e-04	191	71	4	9d0ffa65c547e20b4076fd97776d7738cbd453ec
ToppCell	systemic_lupus_erythematosus-managed-Myeloid-plasmacytoid_dendritic_cell-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	PLXNA4 ST6GALNAC4 TTC39A UNC93B1	2.45e-04	191	71	4	78d523f562d32fc408a20d99b0c61cc103241bc0
ToppCell	Influenza_Severe-RBC\|Influenza_Severe / Disease group and Cell class	ACSL6 GYPC ST6GALNAC4 TAB3	2.50e-04	192	71	4	f19b6da3fd98da1a76d2570137a8f73a3850ebcb
ToppCell	facs-Large_Intestine-Distal-24m-Epithelial-secretory_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	B3GNT5 ST6GALNAC4 TTC39A LIX1	2.55e-04	193	71	4	64bcdbb422f8da6fc3275e82f6aaf562f546a180
ToppCell	facs-Large_Intestine-Distal-24m-Epithelial-Reg4/cKit+_deep_crypt_secretory_cells_(Distal)\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	B3GNT5 ST6GALNAC4 TTC39A LIX1	2.55e-04	193	71	4	5a92697430f16c49e19a5f727d289d7bd1ece31c
ToppCell	normal-na-Myeloid-plasmacytoid_dendritic_cell-female\|normal / PBMC cell types (v2) per disease, treatment status, and sex	PLXNA4 ST6GALNAC4 TTC39A UNC93B1	2.60e-04	194	71	4	74545942aded51a0f4ee96054b4ce12c4d99a8a0
ToppCell	medial-Hematologic-Plasmacytoid_Dendritic\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	PLXNA4 ST6GALNAC4 TTC39A UNC93B1	2.60e-04	194	71	4	bb36274d6fe2d18c545a17d3809f331586502d01
ToppCell	medial-2-Hematologic-Plasmacytoid_Dendritic\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	PLXNA4 ST6GALNAC4 TTC39A UNC93B1	2.60e-04	194	71	4	d58be6454a0795d6771036a1620553a153861615
ToppCell	medial-Hematologic-Plasmacytoid_Dendritic-2\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	PLXNA4 ST6GALNAC4 TTC39A UNC93B1	2.60e-04	194	71	4	0117cd68750153fd6b8978c8b4ce3589486d2b5f
ToppCell	normal-na-Myeloid-plasmacytoid_dendritic_cell\|normal / PBMC cell types (v2) per disease, treatment status, and sex	PLXNA4 ST6GALNAC4 TTC39A UNC93B1	2.60e-04	194	71	4	c25fc353001cdf9fcd772da5a254c857e555eab8
ToppCell	saliva-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	GYPC UQCC2 ST6GALNAC4 DENND11	2.65e-04	195	71	4	a4d36654b968acb1aea252ac203683939461f1d1
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FNDC3B RNF213 DNAH5 LIX1	2.65e-04	195	71	4	938b31dbf1674ee6fd0123bc88391ddcaf151217
ToppCell	saliva-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	GYPC UQCC2 ST6GALNAC4 DENND11	2.65e-04	195	71	4	cd811abd949ef201aef1c8515da5575ab1b1cfea
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FNDC3B RNF213 DNAH5 LIX1	2.65e-04	195	71	4	d39e9e6544f49e677ebe528c6fe60b99a3630e30
ToppCell	saliva-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell-B_c02-MS4A1-CD27\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	GYPC UQCC2 ST6GALNAC4 DENND11	2.70e-04	196	71	4	0175b097ad1338a07afebe3b5c7fd0bb0bb950f7
ToppCell	facs-Brain_Non-Myeloid-Cortex\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NPC1 ACSL6 ERMP1 LIX1	2.70e-04	196	71	4	256fe9bc0815f66a9afe11ba3507ef1372b52fd3
ToppCell	mild-pDC\|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	PLXNA4 ST6GALNAC4 TTC39A DAAM1	2.75e-04	197	71	4	15230a54fa5903dd728de1a0ad633bd2d2c7a04d
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NPC1 ACSL6 ERMP1 LIX1	2.81e-04	198	71	4	a7e5de81eb7d3d23812c179a001adbaab1506596
ToppCell	severe-pDC\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	PLXNA4 ST6GALNAC4 TTC39A UNC93B1	2.81e-04	198	71	4	22da4a29b9ff8b94d98bc69b4632a2a58d5dd9e6
ToppCell	MS-Multiple_Sclerosis-Myeloid-pDC\|Multiple_Sclerosis / Disease, condition lineage and cell class	NPC1 PLXNA4 ST6GALNAC4 UNC93B1	2.86e-04	199	71	4	c10c8c9322cad4996e4aa11a8680e3d781644ace
ToppCell	Influenza-Influenza_Severe-Others-RBC\|Influenza_Severe / Disease, condition lineage and cell class	ACSL6 GYPC ST6GALNAC4 TAB3	2.86e-04	199	71	4	da0fec0a492bc3827d9066d2590bcd466cd45564
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_\|World / Primary Cells by Cluster	PLXNA4 CHD3 DAAM1 TTLL7	2.86e-04	199	71	4	058373b4ac3cec2108cb24265628ff0a50646e33
ToppCell	Control-Control-Lymphocyte-T/NK-dn_T\|Control / Disease, condition lineage and cell class	BLM ACSL6 GYPC CHD3	2.92e-04	200	71	4	10882c59b7aaf8bd4b5c00aa4ddbb9f7ac5b2cf5
ToppCell	Substantia_nigra-Macroglia-POLYDENDROCYTE-P3-Tnr-Polydendrocyte.Tnr.Cspg5_(Cspg5)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	PKD2L1 PATE2 DNAH5	4.01e-04	90	71	3	3817a5b0235e632d976ea565175bdbebbd959bf0
ToppCell	Substantia_nigra-Macroglia-POLYDENDROCYTE-P3-Tnr-Polydendrocyte.Tnr.Cspg5_(Cspg5)-\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	PKD2L1 PATE2 DNAH5	4.01e-04	90	71	3	a528f5dcee1a356dea89ff2588d2e0f276f2d5fc
Disease	dilated cardiomyopathy 1S (implicated_via_orthology)	MYH1 MYH13	2.40e-04	10	69	2	DOID:0110454 (implicated_via_orthology)
Disease	autosomal dominant hyaline body myopathy (implicated_via_orthology)	MYH1 MYH13	2.40e-04	10	69	2	DOID:0111269 (implicated_via_orthology)
Disease	congenital myopathy 6 (implicated_via_orthology)	MYH1 MYH13	2.40e-04	10	69	2	DOID:0080719 (implicated_via_orthology)
Disease	distal arthrogryposis type 2B3 (implicated_via_orthology)	MYH1 MYH13	2.40e-04	10	69	2	DOID:0111602 (implicated_via_orthology)
Disease	inclusion body myositis (implicated_via_orthology)	MYH1 MYH13	2.40e-04	10	69	2	DOID:3429 (implicated_via_orthology)
Disease	distal arthrogryposis type 2A (implicated_via_orthology)	MYH1 MYH13	2.40e-04	10	69	2	DOID:0111605 (implicated_via_orthology)
Disease	familial hypertrophic cardiomyopathy (implicated_via_orthology)	MYH1 MYH13	2.40e-04	10	69	2	DOID:0080326 (implicated_via_orthology)
Disease	distal arthrogryposis type 1 (implicated_via_orthology)	MYH1 MYH13	2.40e-04	10	69	2	DOID:0111596 (implicated_via_orthology)
Disease	distal myopathy (implicated_via_orthology)	MYH1 MYH13	3.50e-04	12	69	2	DOID:11720 (implicated_via_orthology)
Disease	myotonia congenita (implicated_via_orthology)	MYH1 MYH13	3.50e-04	12	69	2	DOID:2106 (implicated_via_orthology)
Disease	restrictive cardiomyopathy (implicated_via_orthology)	MYH1 MYH13	4.13e-04	13	69	2	DOID:397 (implicated_via_orthology)
Disease	distal arthrogryposis (implicated_via_orthology)	MYH1 MYH13	5.55e-04	15	69	2	DOID:0050646 (implicated_via_orthology)
Disease	partial epilepsy	ELOVL4 SLC33A1	7.16e-04	17	69	2	EFO_0004263
Disease	Immunologic Deficiency Syndromes	BLM C4A	1.32e-03	23	69	2	C0021051
Disease	retinitis pigmentosa (implicated_via_orthology)	PDE6A AGTPBP1	1.82e-03	27	69	2	DOID:10584 (implicated_via_orthology)
Disease	Liver Cirrhosis	NPC1 UNC93B1 F5	1.83e-03	103	69	3	C0023890
Disease	Fibrosis, Liver	NPC1 UNC93B1 F5	1.93e-03	105	69	3	C0239946
Disease	corneal topography	FNDC3B CHSY1 LRRK1	2.15e-03	109	69	3	EFO_0004345
GeneOntologyMolecularFunction	fatty acid elongase activity	ELOVL4 ELOVL1 ELOVL3	1.43e-06	7	70	3	GO:0009922
GeneOntologyMolecularFunction	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity	CHSY1 CHSY3	7.24e-05	4	70	2	GO:0050510
GeneOntologyMolecularFunction	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity	CHSY1 CHSY3	1.80e-04	6	70	2	GO:0047238
GeneOntologyMolecularFunction	complement component C1q complex binding	C4A C4B	5.35e-04	10	70	2	GO:0001849
GeneOntologyBiologicalProcess	long-chain fatty-acyl-CoA biosynthetic process	ELOVL4 ACSL6 ELOVL1 ELOVL3	4.03e-07	19	68	4	GO:0035338
GeneOntologyBiologicalProcess	fatty acid elongation, polyunsaturated fatty acid	ELOVL4 ELOVL1 ELOVL3	1.19e-06	7	68	3	GO:0034626
GeneOntologyBiologicalProcess	fatty acid elongation, monounsaturated fatty acid	ELOVL4 ELOVL1 ELOVL3	1.19e-06	7	68	3	GO:0034625
GeneOntologyBiologicalProcess	fatty acid elongation, unsaturated fatty acid	ELOVL4 ELOVL1 ELOVL3	1.19e-06	7	68	3	GO:0019368
GeneOntologyBiologicalProcess	long-chain fatty-acyl-CoA metabolic process	ELOVL4 ACSL6 ELOVL1 ELOVL3	1.79e-06	27	68	4	GO:0035336
GeneOntologyBiologicalProcess	fatty-acyl-CoA biosynthetic process	ELOVL4 ACSL6 ELOVL1 ELOVL3	1.79e-06	27	68	4	GO:0046949
GeneOntologyBiologicalProcess	fatty acid elongation, saturated fatty acid	ELOVL4 ELOVL1 ELOVL3	1.90e-06	8	68	3	GO:0019367
GeneOntologyBiologicalProcess	sphingolipid biosynthetic process	ELOVL4 ENPP7 B3GNT5 ELOVL1 ELOVL3 ST6GALNAC4	2.41e-06	117	68	6	GO:0030148
GeneOntologyBiologicalProcess	very long-chain fatty acid metabolic process	ELOVL4 ACSL6 ELOVL1 ELOVL3	5.24e-06	35	68	4	GO:0000038
GeneOntologyBiologicalProcess	very long-chain fatty acid biosynthetic process	ELOVL4 ELOVL1 ELOVL3	9.57e-06	13	68	3	GO:0042761
GeneOntologyBiologicalProcess	fatty-acyl-CoA metabolic process	ELOVL4 ACSL6 ELOVL1 ELOVL3	1.10e-05	42	68	4	GO:0035337
GeneOntologyBiologicalProcess	membrane lipid biosynthetic process	ELOVL4 ENPP7 B3GNT5 ELOVL1 ELOVL3 ST6GALNAC4	1.31e-05	157	68	6	GO:0046467
GeneOntologyBiologicalProcess	fatty acid elongation	ELOVL4 ELOVL1 ELOVL3	1.52e-05	15	68	3	GO:0030497
GeneOntologyBiologicalProcess	acyl-CoA biosynthetic process	ELOVL4 ACSL6 ELOVL1 ELOVL3	2.05e-05	49	68	4	GO:0071616
GeneOntologyBiologicalProcess	thioester biosynthetic process	ELOVL4 ACSL6 ELOVL1 ELOVL3	2.05e-05	49	68	4	GO:0035384
GeneOntologyBiologicalProcess	amide biosynthetic process	ELOVL4 ACSL6 ENPP7 ELOVL1 ELOVL3 ST6GALNAC4	2.20e-05	172	68	6	GO:0043604
GeneOntologyBiologicalProcess	sphingolipid metabolic process	ELOVL4 ENPP7 B3GNT5 ELOVL1 ELOVL3 ST6GALNAC4	2.50e-05	176	68	6	GO:0006665
GeneOntologyBiologicalProcess	fatty acid derivative biosynthetic process	ELOVL4 ACSL6 ELOVL1 ELOVL3	2.60e-05	52	68	4	GO:1901570
GeneOntologyBiologicalProcess	sulfur compound biosynthetic process	ELOVL4 ACSL6 ELOVL1 CHSY1 ELOVL3 CHSY3	2.67e-05	178	68	6	GO:0044272
GeneOntologyBiologicalProcess	nucleoside bisphosphate biosynthetic process	ELOVL4 ACSL6 ELOVL1 ELOVL3	4.89e-05	61	68	4	GO:0033866
GeneOntologyBiologicalProcess	ribonucleoside bisphosphate biosynthetic process	ELOVL4 ACSL6 ELOVL1 ELOVL3	4.89e-05	61	68	4	GO:0034030
GeneOntologyBiologicalProcess	purine nucleoside bisphosphate biosynthetic process	ELOVL4 ACSL6 ELOVL1 ELOVL3	4.89e-05	61	68	4	GO:0034033
GeneOntologyBiologicalProcess	membrane lipid metabolic process	ELOVL4 ENPP7 B3GNT5 ELOVL1 ELOVL3 ST6GALNAC4	1.08e-04	229	68	6	GO:0006643
GeneOntologyBiologicalProcess	peptidyl-glutamic acid modification	TTLL8 AGTPBP1 TTLL7	1.18e-04	29	68	3	GO:0018200
GeneOntologyBiologicalProcess	fatty acid derivative metabolic process	ELOVL4 ACSL6 ELOVL1 ELOVL3	1.56e-04	82	68	4	GO:1901568
GeneOntologyBiologicalProcess	positive regulation of apoptotic cell clearance	C4A C4B	2.96e-04	8	68	2	GO:2000427
GeneOntologyBiologicalProcess	lipid biosynthetic process	ELOVL4 ACSL6 ENPP7 MBOAT1 B3GNT5 PSG3 FIG4 ELOVL1 ELOVL3 ST6GALNAC4	3.14e-04	813	68	10	GO:0008610
GeneOntologyBiologicalProcess	acyl-CoA metabolic process	ELOVL4 ACSL6 ELOVL1 ELOVL3	4.63e-04	109	68	4	GO:0006637
GeneOntologyBiologicalProcess	thioester metabolic process	ELOVL4 ACSL6 ELOVL1 ELOVL3	4.63e-04	109	68	4	GO:0035383
GeneOntologyBiologicalProcess	alpha-linolenic acid metabolic process	ELOVL1 ELOVL3	4.74e-04	10	68	2	GO:0036109
GeneOntologyBiologicalProcess	regulation of apoptotic cell clearance	C4A C4B	4.74e-04	10	68	2	GO:2000425
GeneOntologyBiologicalProcess	carbohydrate derivative biosynthetic process	NPC1 ELOVL4 ACSL6 B3GNT5 ELOVL1 CHSY1 ELOVL3 CHSY3 ST6GALNAC4	6.69e-04	736	68	9	GO:1901137
GeneOntologyBiologicalProcess	negative regulation of thymocyte apoptotic process	BLM RAG1	8.16e-04	13	68	2	GO:0070244
GeneOntologyBiologicalProcess	unsaturated fatty acid biosynthetic process	ELOVL4 ELOVL1 ELOVL3	8.38e-04	56	68	3	GO:0006636
GeneOntologyCellularComponent	symbiont cell surface	C4A C4B	3.06e-04	8	70	2	GO:0106139
GeneOntologyCellularComponent	other organism part	C4A C4B	3.92e-04	9	70	2	GO:0044217
Domain	ELO_CS	ELOVL4 ELOVL1 ELOVL3	9.16e-07	6	68	3	IPR030457
Domain	ELO	ELOVL4 ELOVL1 ELOVL3	1.60e-06	7	68	3	PF01151
Domain	ELO	ELOVL4 ELOVL1 ELOVL3	1.60e-06	7	68	3	PS01188
Domain	ELO_fam	ELOVL4 ELOVL1 ELOVL3	1.60e-06	7	68	3	IPR002076
Domain	Anaphylatoxin_comp_syst	C4A C4B	1.30e-04	5	68	2	IPR018081
Domain	Anaphylatoxn_comp_syst_dom	C4A C4B	1.30e-04	5	68	2	IPR001840
Domain	ANATO	C4A C4B	2.71e-04	7	68	2	SM00104
Domain	ANATO	C4A C4B	2.71e-04	7	68	2	PF01821
Domain	ANAPHYLATOXIN_2	C4A C4B	2.71e-04	7	68	2	PS01178
Domain	ANAPHYLATOXIN_1	C4A C4B	2.71e-04	7	68	2	PS01177
Domain	Anaphylatoxin/fibulin	C4A C4B	2.71e-04	7	68	2	IPR000020
Domain	DNA/RNA_helicase_DEAH_CS	BLM CHD3 DHX29	2.78e-04	35	68	3	IPR002464
Domain	DEAH_ATP_HELICASE	BLM CHD3 DHX29	3.55e-04	38	68	3	PS00690
Domain	Chond_GalNAc	CHSY1 CHSY3	3.61e-04	8	68	2	IPR008428
Domain	Thiol-ester_cl	C4A C4B	3.61e-04	8	68	2	PF10569
Domain	MacrogloblnA2_thiol-ester-bond	C4A C4B	3.61e-04	8	68	2	IPR019565
Domain	MacrogloblnA2_CS	C4A C4B	3.61e-04	8	68	2	IPR019742
Domain	CHGN	CHSY1 CHSY3	3.61e-04	8	68	2	PF05679
Domain	A2M_N	C4A C4B	5.77e-04	10	68	2	PF01835
Domain	A2M_N	C4A C4B	5.77e-04	10	68	2	IPR002890
Domain	A-macroglobulin_rcpt-bd	C4A C4B	5.77e-04	10	68	2	IPR009048
Domain	ALPHA_2_MACROGLOBULIN	C4A C4B	5.77e-04	10	68	2	PS00477
Domain	A2M	C4A C4B	5.77e-04	10	68	2	PF00207
Domain	A2M_N_2	C4A C4B	5.77e-04	10	68	2	IPR011625
Domain	A2M_comp	C4A C4B	5.77e-04	10	68	2	IPR011626
Domain	A2M_N_2	C4A C4B	5.77e-04	10	68	2	PF07703
Domain	A2M_recep	C4A C4B	5.77e-04	10	68	2	PF07677
Domain	A2M_comp	C4A C4B	5.77e-04	10	68	2	PF07678
Domain	Macroglobln_a2	C4A C4B	5.77e-04	10	68	2	IPR001599
Domain	Myosin_N	MYH1 MYH13	1.33e-03	15	68	2	PF02736
Domain	Myosin_N	MYH1 MYH13	1.33e-03	15	68	2	IPR004009
Domain	C345C	C4A C4B	1.71e-03	17	68	2	SM00643
Domain	Myosin_tail_1	MYH1 MYH13	1.92e-03	18	68	2	PF01576
Domain	Myosin_tail	MYH1 MYH13	1.92e-03	18	68	2	IPR002928
Domain	Terpenoid_cyclase/PrenylTrfase	C4A C4B	1.92e-03	18	68	2	IPR008930
Domain	NTR	C4A C4B	2.15e-03	19	68	2	PF01759
Domain	Myosin-like_IQ_dom	MYH1 MYH13	2.15e-03	19	68	2	IPR027401
Domain	-	MYH1 MYH13	2.15e-03	19	68	2	4.10.270.10
Domain	Netrin_module_non-TIMP	C4A C4B	2.15e-03	19	68	2	IPR018933
Domain	NTR	C4A C4B	3.15e-03	23	68	2	PS50189
Domain	Netrin_domain	C4A C4B	3.15e-03	23	68	2	IPR001134
Domain	TIMP-like_OB-fold	C4A C4B	4.01e-03	26	68	2	IPR008993
Domain	Helicase_C	BLM CHD3 DHX29	6.99e-03	107	68	3	PF00271
Pathway	REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS	ELOVL4 ACSL6 ELOVL1 ELOVL3	2.08e-06	24	55	4	M1016
Pathway	WP_ELONGATION_OF_VERY_LONG_CHAIN_FATTY_ACIDS	ELOVL4 ELOVL1 ELOVL3	1.21e-05	12	55	3	MM17077
Pathway	REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS	ELOVL4 ACSL6 ELOVL1 ELOVL3	1.24e-05	37	55	4	M729
Pathway	REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS	ACSL6 ELOVL1 ELOVL3	8.21e-05	22	55	3	MM15451
Pathway	REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS	ACSL6 ELOVL1 ELOVL3	2.57e-04	32	55	3	MM15446
Pathway	REACTOME_ACTIVATION_OF_C3_AND_C5	C4A C4B	3.10e-04	7	55	2	MM14685
Pathway	REACTOME_LINOLEIC_ACID_LA_METABOLISM	ELOVL1 ELOVL3	4.12e-04	8	55	2	MM14822
Pathway	REACTOME_ACTIVATION_OF_C3_AND_C5	C4A C4B	4.12e-04	8	55	2	M27031
Pathway	REACTOME_LINOLEIC_ACID_LA_METABOLISM	ELOVL1 ELOVL3	4.12e-04	8	55	2	M27115
Pathway	KEGG_MEDICUS_REFERENCE_CLASSICAL_PATHWAY_OF_COMPLEMENT_CASCADE_C4_C2_TO_C3_CONVERTASE_FORMATION	C4A C4B	4.12e-04	8	55	2	M47872
Pathway	KEGG_MEDICUS_REFERENCE_CHONDROITIN_SULFATE_BIOSYNTHESIS	CHSY1 CHSY3	4.12e-04	8	55	2	M47920
Pathway	REACTOME_CARBOXYTERMINAL_POST_TRANSLATIONAL_MODIFICATIONS_OF_TUBULIN	TTLL8 AGTPBP1 TTLL7	7.58e-04	46	55	3	M27828
Pathway	REACTOME_ALPHA_PROTEIN_KINASE_1_SIGNALING_PATHWAY	ALPK1 TAB3	8.04e-04	11	55	2	M29827
Pathway	BIOCARTA_LECTIN_PATHWAY	C4A C4B	8.04e-04	11	55	2	MM1430
Pathway	KEGG_MEDICUS_REFERENCE_LECTIN_PATHWAY_OF_COMPLEMENT_CASCADE_C4_C2_TO_C3_CONVERTASE_FORMATION	C4A C4B	8.04e-04	11	55	2	M47874
Pathway	REACTOME_ALPHA_PROTEIN_KINASE_1_SIGNALING_PATHWAY	ALPK1 TAB3	8.04e-04	11	55	2	MM15668
Pathway	BIOCARTA_CLASSIC_PATHWAY	C4A C4B	9.62e-04	12	55	2	MM1368
Pathway	REACTOME_ALPHA_LINOLENIC_OMEGA3_AND_LINOLEIC_OMEGA6_ACID_METABOLISM	ELOVL1 ELOVL3	1.13e-03	13	55	2	MM14821
Pathway	REACTOME_ALPHA_LINOLENIC_OMEGA3_AND_LINOLEIC_OMEGA6_ACID_METABOLISM	ELOVL1 ELOVL3	1.13e-03	13	55	2	M27114
Pathway	BIOCARTA_LECTIN_PATHWAY	C4A C4B	1.13e-03	13	55	2	M4732
Pathway	WP_OMEGA9_FATTY_ACID_SYNTHESIS	ELOVL1 ELOVL3	1.32e-03	14	55	2	M39780
Pathway	WP_OMEGA9_FATTY_ACID_SYNTHESIS	ELOVL1 ELOVL3	1.32e-03	14	55	2	MM15840
Pathway	KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES	ST6GALNAC4 SLC33A1	1.52e-03	15	55	2	M8535
Pathway	BIOCARTA_CLASSIC_PATHWAY	C4A C4B	1.52e-03	15	55	2	M7146
Pathway	WP_COMPLEMENT_ACTIVATION_CLASSICAL_PATHWAY	C4A C4B	1.96e-03	17	55	2	MM15944
Pathway	BIOCARTA_COMP_PATHWAY	C4A C4B	1.96e-03	17	55	2	MM1369
Pathway	REACTOME_METABOLISM_OF_LIPIDS	ELOVL4 MED24 ACSL6 ENPP7 MBOAT1 B3GNT5 FIG4 ELOVL1 ELOVL3	2.44e-03	757	55	9	M27451
Pathway	REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS	CHSY1 CHSY3	2.45e-03	19	55	2	MM14800
Pathway	KEGG_COMPLEMENT_AND_COAGULATION_CASCADES	C4A C4B F5	2.45e-03	69	55	3	M16894
Pathway	BIOCARTA_COMP_PATHWAY	C4A C4B	2.71e-03	20	55	2	M917
Pathway	REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS	CHSY1 CHSY3	2.71e-03	20	55	2	M658
Pubmed	Enhanced transcription of complement and coagulation genes in the absence of adaptive immunity.	RAG1 C4A C4B	8.15e-09	3	71	3	19200601
Pubmed	Innate response to self-antigen significantly exacerbates burn wound depth.	RAG1 C4A C4B	8.15e-09	3	71	3	17360462
Pubmed	Intestinal reperfusion injury is mediated by IgM and complement.	RAG1 C4A C4B	3.26e-08	4	71	3	10066708
Pubmed	A platelet-mediated system for shuttling blood-borne bacteria to CD8α+ dendritic cells depends on glycoprotein GPIb and complement C3.	RAG1 C4A C4B	2.84e-07	7	71	3	22037602
Pubmed	Biosynthesis of triacylglycerols.	ELOVL4 ACSL6 ELOVL1 ELOVL3	3.15e-07	28	71	4	8944226
Pubmed	ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis.	ELOVL4 ELOVL1 ELOVL3	9.68e-07	10	71	3	20937905
Pubmed	Impaired epidermal permeability barrier in mice lacking elovl1, the gene responsible for very-long-chain fatty acid production.	ELOVL4 ELOVL1 ELOVL3	1.33e-06	11	71	3	23689133
Pubmed	Copy number analysis of complement C4A, C4B and C4A silencing mutation by real-time quantitative polymerase chain reaction.	C4A C4B	4.11e-06	2	71	2	22737222
Pubmed	Deficiency of C4 from donor or recipient mouse fails to prevent renal allograft rejection.	C4A C4B	4.11e-06	2	71	2	16565498
Pubmed	Complete deficiencies of complement C4A and C4B including 2-bp insertion in codon 1213 are genetic risk factors of systemic lupus erythematosus in Thai populations.	C4A C4B	4.11e-06	2	71	2	15998580
Pubmed	Structural polymorphism of murine C4 and its linkage to H-2.	C4A C4B	4.11e-06	2	71	2	7373044
Pubmed	High-throughput analysis of the C4 polymorphism by a combination of MLPA and isotype-specific ELISA's.	C4A C4B	4.11e-06	2	71	2	19062096
Pubmed	The chemical structure of the C4d fragment of the human complement component C4.	C4A C4B	4.11e-06	2	71	2	3696167
Pubmed	Restriction fragment length polymorphism of the murine C4 and Slp genes: two C4 groups.	C4A C4B	4.11e-06	2	71	2	1357031
Pubmed	Structural comparison of human C4A3 and C4B1 after proteolytic activation by C1s.	C4A C4B	4.11e-06	2	71	2	16098595
Pubmed	Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice.	C4A C4B	4.11e-06	2	71	2	19933335
Pubmed	Structural basis for the C4d.1/C4d.2 serologic allotypes of murine complement component C4.	C4A C4B	4.11e-06	2	71	2	2459207
Pubmed	Antigen-induced B cell apoptosis is independent of complement C4.	C4A C4B	4.11e-06	2	71	2	17645767
Pubmed	Increased frequency of C4B*Q0 alleles in patients with Henoch-Schönlein purpura.	C4A C4B	4.11e-06	2	71	2	15787745
Pubmed	Anti-DNA autoreactivity in C4-deficient mice.	C4A C4B	4.11e-06	2	71	2	12207352
Pubmed	Neuropil contraction in relation to Complement C4 gene copy numbers in independent cohorts of adolescent-onset and young adult-onset schizophrenia patients-a pilot study.	C4A C4B	4.11e-06	2	71	2	30026462
Pubmed	A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor B.	C4A C4B	4.11e-06	2	71	2	6559257
Pubmed	Complement C4A and C4B Gene Copy Number Study in Alzheimer's Disease Patients.	C4A C4B	4.11e-06	2	71	2	27758680
Pubmed	Genetically determined partial complement C4 deficiency states are not independent risk factors for SLE in UK and Spanish populations.	C4A C4B	4.11e-06	2	71	2	22387014
Pubmed	Complement C4 Is Reduced in iPSC-Derived Astrocytes of Autism Spectrum Disorder Subjects.	C4A C4B	4.11e-06	2	71	2	34299197
Pubmed	Assessment of complement C4 gene copy number using the paralog ratio test.	C4A C4B	4.11e-06	2	71	2	20506482
Pubmed	Polymerase chain reaction based C4AQ0 and C4BQ0 genotyping: association with systemic lupus erythematosus in southwest Han Chinese.	C4A C4B	4.11e-06	2	71	2	12480675
Pubmed	Low C4, C4A and C4B gene copy numbers are stronger risk factors for juvenile-onset than for adult-onset systemic lupus erythematosus.	C4A C4B	4.11e-06	2	71	2	26800705
Pubmed	Complement C4 maintains peripheral B-cell tolerance in a myeloid cell dependent manner.	C4A C4B	4.11e-06	2	71	2	23749435
Pubmed	Copy number variations of complement component C4 are associated with Behçet's disease but not with ankylosing spondylitis associated with acute anterior uveitis.	C4A C4B	4.11e-06	2	71	2	23918728
Pubmed	Murine complement C4 is not required for experimental autoimmune encephalomyelitis.	C4A C4B	4.11e-06	2	71	2	15390104
Pubmed	Molecular genetics of androgen-dependent and -independent expression of mouse sex-limited protein.	C4A C4B	4.11e-06	2	71	2	3037333
Pubmed	Enhanced expression of matrix metalloproteinase-12 contributes to Npc1 deficiency-induced axonal degeneration.	NPC1 MMP12	4.11e-06	2	71	2	25864931
Pubmed	Evidence of a role for C4 in modulating interstitial inflammation in experimental glomerulonephritis.	C4A C4B	4.11e-06	2	71	2	11726230
Pubmed	Quantitative variations in the expression of the mouse serum antigen Ss and its sex-limited allotype Slp.	C4A C4B	4.11e-06	2	71	2	4216347
Pubmed	Importance of the alpha 3-fragment of complement C4 for the binding with C4b-binding protein.	C4A C4B	4.11e-06	2	71	2	1699796
Pubmed	Sequence determination of the thiolester site of the fourth component of human complement.	C4A C4B	4.11e-06	2	71	2	6950384
Pubmed	Molecular cloning and characterization of complementary and genomic DNA clones for mouse C4 and Slp.	C4A C4B	4.11e-06	2	71	2	2997024
Pubmed	Visual demonstration of the organization of the human complement C4 and 21-hydroxylase genes by high-resolution fluorescence in situ hybridization.	C4A C4B	4.11e-06	2	71	2	8660986
Pubmed	Constitutive expression of Slp genes in mouse strain B10.WR directed by C4 regulatory sequences.	C4A C4B	4.11e-06	2	71	2	3624865
Pubmed	Tissue-specific RNA processing for the complement C4 gene transcript in the H-2k mouse strain.	C4A C4B	4.11e-06	2	71	2	8428773
Pubmed	Determination of the loss of function complement C4 exon 29 CT insertion using a novel paralog-specific assay in healthy UK and Spanish populations.	C4A C4B	4.11e-06	2	71	2	21857912
Pubmed	Complement C4 deficiency--a plausible risk factor for non-tuberculous mycobacteria (NTM) infection in apparently immunocompetent patients.	C4A C4B	4.11e-06	2	71	2	24638111
Pubmed	Isolation of cDNA clones specifying the fourth component of mouse complement and its isotype, sex-limited protein.	C4A C4B	4.11e-06	2	71	2	6208559
Pubmed	The role of the histocompatibility-2-linked Ss-Slp region in the control of mouse complement.	C4A C4B	4.11e-06	2	71	2	4514997
Pubmed	Transcriptional repression of C4 complement by hepatitis C virus proteins.	C4A C4B	4.11e-06	2	71	2	21345967
Pubmed	The inheritance of susceptibility to the Gross leukemia virus in mice.	C4A C4B	4.11e-06	2	71	2	5919331
Pubmed	An ancient provirus has imposed androgen regulation on the adjacent mouse sex-limited protein gene.	C4A C4B	4.11e-06	2	71	2	3167981
Pubmed	The dichotomous size variation of human complement C4 genes is mediated by a novel family of endogenous retroviruses, which also establishes species-specific genomic patterns among Old World primates.	C4A C4B	4.11e-06	2	71	2	7545960
Pubmed	Insights on the relationship between complement component C4 serum concentrations and C4 gene copy numbers in a Western Australian systemic lupus erythematosus cohort.	C4A C4B	4.11e-06	2	71	2	30041577
Pubmed	Restriction fragment analysis of H-2 recombinant mouse strains with crossovers between E alpha and C4 genes.	C4A C4B	4.11e-06	2	71	2	2572548
Pubmed	The complement component C4 of mammals.	C4A C4B	4.11e-06	2	71	2	2302180
Pubmed	Complete cDNA sequence of the fourth component of murine complement.	C4A C4B	4.11e-06	2	71	2	3862104
Pubmed	The BS variant of C4 protects against age-related loss of white matter microstructural integrity.	C4A C4B	4.11e-06	2	71	2	34358307
Pubmed	Acute renal allograft rejection: diagnostic significance of focal peritubular capillary C4d.	C4A C4B	4.11e-06	2	71	2	18360261
Pubmed	Gene CNVs and protein levels of complement C4A and C4B as novel biomarkers for partial disease remissions in new-onset type 1 diabetes patients.	C4A C4B	4.11e-06	2	71	2	22151770
Pubmed	C4d-positive chronic rejection: a frequent entity with a poor outcome.	C4A C4B	4.11e-06	2	71	2	18091514
Pubmed	Comprehensive approach to study complement C4 in systemic lupus erythematosus: Gene polymorphisms, protein levels and functional activity.	C4A C4B	4.11e-06	2	71	2	29080553
Pubmed	Schizophrenia risk from complex variation of complement component 4.	C4A C4B	4.11e-06	2	71	2	26814963
Pubmed	Genes for murine fourth complement component (C4) and sex-limited protein (Slp) identified by hybridization to C4- and Slp-specific cDNA.	C4A C4B	4.11e-06	2	71	2	6589636
Pubmed	C4 Deficiency is a predisposing factor for Streptococcus pneumoniae-induced autoantibody production.	C4A C4B	4.11e-06	2	71	2	25339671
Pubmed	A study of association of the complement C4 mutations with systemic lupus erythematosus in the Malaysian population.	C4A C4B	4.11e-06	2	71	2	17728371
Pubmed	Structure and organization of the C4 genes.	C4A C4B	4.11e-06	2	71	2	6149580
Pubmed	Sequence heterogeneity of murine complementary DNA clones related to the C4 and C4-Slp isoforms of the fourth complement component.	C4A C4B	4.11e-06	2	71	2	6149581
Pubmed	The follicular dendritic cell restricted epitope, FDC-M2, is complement C4; localization of immune complexes in mouse tissues.	C4A C4B	4.11e-06	2	71	2	12115608
Pubmed	Biochemistry and biology of anaphylatoxins.	C4A C4B	4.11e-06	2	71	2	3542363
Pubmed	C4 from C4-high and C4-low mouse strains have identical sequences in the region corresponding to the isotype-specific segment of human C4.	C4A C4B	4.11e-06	2	71	2	2387317
Pubmed	Promoter elements of the mouse complement C4 gene critical for transcription activation and start site location.	C4A C4B	4.11e-06	2	71	2	8132550
Pubmed	Substitution of a single amino acid (aspartic acid for histidine) converts the functional activity of human complement C4B to C4A.	C4A C4B	4.11e-06	2	71	2	2395880
Pubmed	Effects of Complement C4 Gene Copy Number Variations, Size Dichotomy, and C4A Deficiency on Genetic Risk and Clinical Presentation of Systemic Lupus Erythematosus in East Asian Populations.	C4A C4B	4.11e-06	2	71	2	26814708
Pubmed	cDNA clone spanning the alpha-gamma subunit junction in the precursor of the murine fourth complement component (C4).	C4A C4B	4.11e-06	2	71	2	6192448
Pubmed	Complete primary structure of human C4a anaphylatoxin.	C4A C4B	4.11e-06	2	71	2	6167582
Pubmed	Identification of the size and antigenic determinants of the human C4 gene by a polymerase chain-reaction-based amplification method.	C4A C4B	4.11e-06	2	71	2	16908004
Pubmed	Slp is an essential component of an EDTA-resistant activation pathway of mouse complement.	C4A C4B	4.11e-06	2	71	2	1438267
Pubmed	Structural studies on the murine fourth component of complement (C4). IV. Demonstration that C4 and Slp are encoded by separate loci.	C4A C4B	4.11e-06	2	71	2	7365238
Pubmed	Genetic deficiency of complement isoforms C4A or C4B predicts improved survival of metastatic renal cell carcinoma.	C4A C4B	4.11e-06	2	71	2	19150565
Pubmed	Chondroitin sulfate synthase-3. Molecular cloning and characterization.	CHSY1 CHSY3	4.11e-06	2	71	2	12907687
Pubmed	Interaction between the labile binding sites of the fourth (C4) and fifth (C5) human complement proteins and erythrocyte cell membranes.	C4A C4B	4.11e-06	2	71	2	7391573
Pubmed	Elevated levels of endogenous apoptotic DNA and IFN-alpha in complement C4-deficient mice: implications for induction of systemic lupus erythematosus.	C4A C4B	4.11e-06	2	71	2	17506029
Pubmed	Peritubular capillary C4d deposition in lupus nephritis different from antibody-mediated renal rejection.	C4A C4B	4.11e-06	2	71	2	17971360
Pubmed	Low C4 gene copy numbers are associated with superior graft survival in patients transplanted with a deceased donor kidney.	C4A C4B	4.11e-06	2	71	2	23715124
Pubmed	Identification of the 5'-flanking regulatory region responsible for the difference in transcriptional control between mouse complement C4 and Slp genes.	C4A C4B	4.11e-06	2	71	2	3464002
Pubmed	Complete nucleotide and derived amino acid sequences of the fourth component of mouse complement (C4). Evolutionary aspects.	C4A C4B	4.11e-06	2	71	2	2993295
Pubmed	Clinical features of patients with homozygous complement C4A or C4B deficiency.	C4A C4B	4.11e-06	2	71	2	29928053
Pubmed	Analysis of C4 and the C4 binding protein in the MRL/lpr mouse.	C4A C4B	4.11e-06	2	71	2	17971229
Pubmed	Genetic deficiency of C4 presenting with recurrent infections and a SLE-like disease. Genetic and immunologic studies.	C4A C4B	4.11e-06	2	71	2	6881182
Pubmed	Identification of the site of sulfation of the fourth component of human complement.	C4A C4B	4.11e-06	2	71	2	3944109
Pubmed	Partial C4 deficiency in juvenile idiopathic arthritis patients.	C4A C4B	4.11e-06	2	71	2	17921792
Pubmed	Complement activation and complement receptors on follicular dendritic cells are critical for the function of a targeted adjuvant.	C4A C4B	4.11e-06	2	71	2	21880985
Pubmed	Amino acid sequence around the thiol and reactive acyl groups of human complement component C4.	C4A C4B	4.11e-06	2	71	2	6978711
Pubmed	Plasma Complement 3 and Complement 4 Are Promising Biomarkers for Distinguishing NMOSD From MOGAD and Are Associated With the Blood-Brain-Barrier Disruption in NMOSD.	C4A C4B	4.11e-06	2	71	2	35898513
Pubmed	Overexpression of schizophrenia susceptibility factor human complement C4A promotes excessive synaptic loss and behavioral changes in mice.	C4A C4B	4.11e-06	2	71	2	33353966
Pubmed	Sequence comparison of alleles of the fourth component of complement (C4) and sex-limited protein (Slp).	C4A C4B	4.11e-06	2	71	2	3008092
Pubmed	Borrelia burgdorferi outer surface protein C (OspC) binds complement component C4b and confers bloodstream survival.	C4A C4B	4.11e-06	2	71	2	28873507
Pubmed	The molecular basis for the difference in immune hemolysis activity of the Chido and Rodgers isotypes of human complement component C4.	C4A C4B	4.11e-06	2	71	2	6609966
Pubmed	Heterogeneity and linkage of equine C4 and steroid 21-hydroxylase genes.	C4A C4B	4.11e-06	2	71	2	2900855
Pubmed	Studies on the murine Ss protein: demonstration that the Ss protein is functionally the fourth component of complement.	C4A C4B	4.11e-06	2	71	2	276882
Pubmed	Amino acid sequence of a polymorphic segment from fragment C4d of human complement component C4.	C4A C4B	4.11e-06	2	71	2	6832377
Pubmed	Recombination of two homologous MHC class III genes of the mouse (C4 and Slp) that accounts for the loss of testosterone dependence of sex-limited protein expression.	C4A C4B	4.11e-06	2	71	2	3794341
Pubmed	Complement and c4 null alleles in severe chronic adult periodontitis.	C4A C4B	4.11e-06	2	71	2	17257223
GeneFamily	Beta 3-glycosyltransferases	B3GNT5 CHSY1 CHSY3	3.42e-05	24	48	3	426
GeneFamily	Glycosyltransferase family 6\|Blood group antigens	GYPC C4A C4B	1.28e-04	37	48	3	454
GeneFamily	C3 and PZP like, alpha-2-macroglobulin domain containing	C4A C4B	2.46e-04	9	48	2	1234
GeneFamily	Tubulin tyrosine ligase family	TTLL8 TTLL7	6.15e-04	14	48	2	779
GeneFamily	Myosin heavy chains	MYH1 MYH13	7.09e-04	15	48	2	1098
GeneFamily	Beta 4-glycosyltransferases	CHSY1 CHSY3	9.15e-04	17	48	2	425
GeneFamily	Complement system\|Sushi domain containing	C4A C4B	4.10e-03	36	48	2	492
ToppCell	mild-pDC\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	PLXNA4 ST6GALNAC4 TTC39A UNC93B1 LRRK1 DAAM1	7.38e-07	197	71	6	0cb00daa6943f7a7fb34a8fdf51188646af65686
ToppCell	systemic_lupus_erythematosus-treated-Myeloid-plasmacytoid_dendritic_cell-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	NPC1 PLXNA4 ST6GALNAC4 TTC39A UNC93B1	1.08e-05	182	71	5	9bbe8062aa562dc3b9c299581faf6ebbcb72a9f7
ToppCell	systemic_lupus_erythematosus-treated-Myeloid-plasmacytoid_dendritic_cell\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	NPC1 PLXNA4 ST6GALNAC4 TTC39A UNC93B1	1.08e-05	182	71	5	4602a98df7045e2c70b7560abfba9b444fbd5d30
ToppCell	CV-Moderate-7\|Moderate / Virus stimulation, Condition and Cluster	NPC1 URB1 RNF213 ERMP1 AGTPBP1	1.16e-05	185	71	5	a6c9203ce6c2892a4a369c9bcfb85720f01cbb3f
ToppCell	CV-Moderate-7\|CV / Virus stimulation, Condition and Cluster	NPC1 URB1 RNF213 ERMP1 AGTPBP1	1.19e-05	186	71	5	8571956890fc9894d766ba294a28e376b4aba428
ToppCell	Control-Lymphoid-B_Plasma\|Lymphoid / Disease state, Lineage and Cell class	FNDC3B C4B ST6GALNAC4 LRRK1 TTLL7	1.19e-05	186	71	5	a08a50bff4e629588faa22440d57334b1df0e8df
ToppCell	COVID-19_Severe-pDC\|COVID-19_Severe / disease group, cell group and cell class	NPC1 PLXNA4 ST6GALNAC4 TTC39A UNC93B1	1.32e-05	190	71	5	c5ab6b7492fb86aff3d2af3eb671c9f985ae4aeb
ToppCell	Healthy-pDC\|World / disease group, cell group and cell class	NPC1 PLXNA4 ST6GALNAC4 TTC39A UNC93B1	1.36e-05	191	71	5	6e1d825dc33b915b95f13ccd237a552160a4be98
ToppCell	Healthy-pDC\|Healthy / disease group, cell group and cell class	NPC1 PLXNA4 ST6GALNAC4 TTC39A UNC93B1	1.39e-05	192	71	5	33d695a28d22b4af111df9591830a33bb7ef7b2d
ToppCell	VE-pDC-\|VE / Condition, Cell_class and T cell subcluster	NPC1 PLXNA4 ST6GALNAC4 TTC39A LRRK1	1.43e-05	193	71	5	583724de588fcde3aeda056138c522dc0225a387
ToppCell	control-pDC\|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	NPC1 PLXNA4 ST6GALNAC4 TTC39A UNC93B1	1.43e-05	193	71	5	30a6559c9a9e8941861cb259b4836acccc427e68
ToppCell	VE-pDC\|VE / Condition, Cell_class and T cell subcluster	NPC1 PLXNA4 ST6GALNAC4 TTC39A LRRK1	1.43e-05	193	71	5	bb759dc9ef0ec41d655002f59021d62d62d44289
ToppCell	COVID-19-COVID-19_Mild-Myeloid-pDC\|COVID-19_Mild / Disease, condition lineage and cell class	NPC1 PLXNA4 ST6GALNAC4 UNC93B1 DAAM1	1.65e-05	199	71	5	9de61e5189d907cc969ac3043d68204f70acc0bf
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Myeloid-Dendritic-plasmacytoid_dendritic_cell-DC_c4-LILRA4\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	BLM PRMT8 PLXNA4 PATE2	8.06e-05	143	71	4	d0ed8c25da1327085e042c2e03cb7503e2c52ce0
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Myeloid-Dendritic-plasmacytoid_dendritic_cell\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	BLM PRMT8 PLXNA4 PATE2	8.06e-05	143	71	4	8900b92a24289204b9ec7baccc11594fec7694f1
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Degenerative_Ascending_Thin_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PRMT8 MYH13 PLXNA4 LIX1	8.28e-05	144	71	4	163c591fedad2beb7f92531e6240e9554f90ea40
ToppCell	IIH-CD8-proli_CD4\|IIH / Condition, Cell_class and T cell subcluster	TUBGCP6 GET4 PDE6A DHX29	8.73e-05	146	71	4	7fa6e35def3f7cffbee1e1c2f10b523bab678e14
ToppCell	droplet-Lung-18m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell-CD8-positive,_alpha-beta_T_cell_l21\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	BLM CENPC CHD3 CHAMP1	9.45e-05	149	71	4	65778f19599b4955c0a16f0121237656449431fb
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_II-Z\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PDE6A B3GNT5 UNC93B1 DENND11	9.69e-05	150	71	4	6c39e73a0b05d4b26589f333ce13924e3d373b8d
ToppCell	368C-Myeloid-Monocyte-CD16+_Monocyte\|368C / Donor, Lineage, Cell class and subclass (all cells)	PRMT8 USP9Y DENND11 SMCR8	1.13e-04	156	71	4	25b0936960be4955b6a6d6b8a867fdd4be548f05
ToppCell	368C-Myeloid-Macrophage-FABP4+_Macrophage_2\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	PLXNA4 CHSY3 LIX1 TTLL7	1.40e-04	165	71	4	3d2acdae0dd2b79a15f74158e8e566ce22b4218e
ToppCell	facs-Heart-RA-18m-Lymphocytic-B_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RAG1 MYH13 B3GNT5 ARID3B	1.43e-04	166	71	4	fc2cf67311c86fda75b35fcd4768b6f6f14c59d0
ToppCell	facs-Heart-RA-18m-Lymphocytic-B_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RAG1 MYH13 B3GNT5 ARID3B	1.43e-04	166	71	4	33a6876d06e26176135a73a77c19e634ec53f7ce
ToppCell	COVID_vent-Lymphocytic-Dendritic-pDC\|COVID_vent / Disease condition, Lineage, Cell class and subclass	NPC1 PLXNA4 TTC39A LRRK1	1.60e-04	171	71	4	779c951d274ecbd1d546ac425d6c8e718623be5a
ToppCell	COVID_vent-Lymphocytic-Dendritic\|COVID_vent / Disease condition, Lineage, Cell class and subclass	NPC1 PLXNA4 TTC39A LRRK1	1.60e-04	171	71	4	debbb071d260639b16269c94d172766908325c58
ToppCell	wk_15-18-Hematologic-Myeloid-pDC\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	NPC1 ST6GALNAC4 TTC39A UNC93B1	1.68e-04	173	71	4	b571970e3ba88afc07041c5692ccfd85fc39e796
ToppCell	normal_Lymph_Node-B_lymphocytes-GrB-secreting_B_cells\|normal_Lymph_Node / Location, Cell class and cell subclass	RAG1 PLXNA4 UNC93B1 LRRK1	1.75e-04	175	71	4	29fbdfe1d3bfcb063be2bced0128a33176c5b78f
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Ascending_Thin_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FNDC3B PLXNA4 ERMP1 LIX1	1.91e-04	179	71	4	55bc69f107fc710db7617c428575792adfdbbcc1
ToppCell	wk_20-22-Hematologic-Myeloid-pDC\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	NPC1 TTC39A UNC93B1 LRRK1	1.99e-04	181	71	4	60607c5ff6d5b1cb416adc034491dca31c41e988
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FNDC3B PLXNA4 ERMP1 LIX1	2.08e-04	183	71	4	83592c332b1e82673f993d37c7f480befdc3dcda
ToppCell	10x5'-bone_marrow-Myeloid_Dendritic-pDC\|bone_marrow / Manually curated celltypes from each tissue	PLXNA4 ST6GALNAC4 TTC39A UNC93B1	2.12e-04	184	71	4	2817d530863e85dfdcd143b7a3dc5fc58a9cd98b
ToppCell	(7)_MNP-(7)_DC_plasmacytoid\|(7)_MNP / Spleen cell shreds - cell class (v1) and cell subclass (v1)	PLXNA4 ST6GALNAC4 TTC39A DAAM1	2.17e-04	185	71	4	9f67f652488e17075a372e2a2e1100f6d0af6d7d
ToppCell	facs-Large_Intestine-Distal-24m-Epithelial\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	B3GNT5 ST6GALNAC4 TTC39A LIX1	2.17e-04	185	71	4	e29079ef09aee62c3e9756341db4e59ca9dbf7ac
ToppCell	facs-Large_Intestine-Distal-24m\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	B3GNT5 ST6GALNAC4 TTC39A LIX1	2.17e-04	185	71	4	2ecc4b76b3645b65c226c2298bff307cc6479172
ToppCell	healthy_donor-Lymphocytic-Dendritic\|healthy_donor / Disease condition, Lineage, Cell class and subclass	PLXNA4 ST6GALNAC4 TTC39A UNC93B1	2.21e-04	186	71	4	916f2aeea4989ba7a29e071e348a51010f010223
ToppCell	control-Myeloid-pDC\|control / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	NPC1 PLXNA4 ST6GALNAC4 TTC39A	2.21e-04	186	71	4	fe31e9cf4575ee40b50489593c51d8c36c3cc532
ToppCell	PBMC-Severe-Myeloid-pDC-pDC\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PLXNA4 ST6GALNAC4 TTC39A UNC93B1	2.21e-04	186	71	4	b70cd94c651b56dcf2e55554533a5f1130845390
ToppCell	PBMC-Severe-Myeloid-pDC-pDC-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PLXNA4 ST6GALNAC4 TTC39A UNC93B1	2.21e-04	186	71	4	31df1eafa3010bc1be6fc4d4689f1393d69b6b13
ToppCell	control-Myeloid-pDC\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	NPC1 PLXNA4 ST6GALNAC4 TTC39A	2.21e-04	186	71	4	fccee4cfcc887358cf916d974f29627095b5ad9c
ToppCell	systemic_lupus_erythematosus-flare-Myeloid-plasmacytoid_dendritic_cell-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	PLXNA4 ST6GALNAC4 TTC39A UNC93B1	2.21e-04	186	71	4	a07694caf7fede06a47636725bcc7f09909cdf07
ToppCell	PBMC-Severe-Myeloid-pDC\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PLXNA4 ST6GALNAC4 TTC39A UNC93B1	2.21e-04	186	71	4	eaa431ccd4cdd36fe06a44987603ec9979025aa8
ToppCell	COVID-19_Severe-Myeloid-pDC\|COVID-19_Severe / Disease group, lineage and cell class	PLXNA4 ST6GALNAC4 TTC39A UNC93B1	2.21e-04	186	71	4	3db5ed69d49e5d79f990aca0295ddce4c297a05c
ToppCell	PBMC-Severe-Myeloid-pDC\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	PLXNA4 ST6GALNAC4 TTC39A UNC93B1	2.21e-04	186	71	4	b95be984e308d4f9061274a35995ec558d434e74
ToppCell	PBMC-Severe-Myeloid-pDC-pDC-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	PLXNA4 ST6GALNAC4 TTC39A UNC93B1	2.21e-04	186	71	4	8f7949740286f64e034d1eb533ebc2c6f71ae966
ToppCell	healthy_donor-Lymphocytic-Dendritic-pDC\|healthy_donor / Disease condition, Lineage, Cell class and subclass	PLXNA4 ST6GALNAC4 TTC39A UNC93B1	2.21e-04	186	71	4	45f66619e45d590c7365a51782d4ac46b7d31fde
ToppCell	PBMC-Severe-Myeloid-pDC-pDC\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	PLXNA4 ST6GALNAC4 TTC39A UNC93B1	2.21e-04	186	71	4	95c7318e521fb6aa02e244b1e81e6b2a62107756
ToppCell	(0)_Myeloid-(01)_Dendritic_cell-(011)_pDC\|(01)_Dendritic_cell / immune cells in Peripheral Blood (logTPM normalization)	NPC1 PLXNA4 ST6GALNAC4 TTC39A	2.26e-04	187	71	4	068502efa3f0ac4cea2fa4a18d1c2f686a4fba54
ToppCell	facs-Large_Intestine-Distal-18m\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	B3GNT5 ST6GALNAC4 TTC39A LIX1	2.26e-04	187	71	4	a4c408fc941d2e8a811a26aa916c0b3e3341163a
ToppCell	facs-Large_Intestine-Distal-18m-Epithelial\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	B3GNT5 ST6GALNAC4 TTC39A LIX1	2.26e-04	187	71	4	ab109aa51beae3df474c15002e70361f328cadad
ToppCell	Leuk-UTI-Myeloid-pDC\|Leuk-UTI / Disease, Lineage and Cell Type	PLXNA4 ST6GALNAC4 TTC39A DAAM1	2.26e-04	187	71	4	e3035b1f65ab12b8f01799b8e5d6633b9b584a06
ToppCell	control-pDC\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	PLXNA4 ST6GALNAC4 TTC39A UNC93B1	2.26e-04	187	71	4	c78aee98b32719aa45811b620fc97be1ecf5fd53
ToppCell	(0)_Myeloid-(011)_pDC\|(0)_Myeloid / immune cells in Peripheral Blood (logTPM normalization)	NPC1 PLXNA4 ST6GALNAC4 TTC39A	2.31e-04	188	71	4	a81b5d840490d6a636fe168f8cff2c4984369f09
ToppCell	PBMC-Mild-Myeloid-pDC\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	PLXNA4 ST6GALNAC4 TTC39A UNC93B1	2.31e-04	188	71	4	de6a270b6e4fe09c39a52c296632d86ada98465b
ToppCell	PBMC-Mild-Myeloid-pDC-pDC\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	PLXNA4 ST6GALNAC4 TTC39A UNC93B1	2.31e-04	188	71	4	89411c4db3df5e1dc36cf8af4ffcc0abbecbe4df
ToppCell	COVID-19_Severe-pDC\|World / disease group, cell group and cell class	PLXNA4 ST6GALNAC4 TTC39A UNC93B1	2.31e-04	188	71	4	4c8e328b8206120708b05ea3c5865a0200dc5c4e
ToppCell	PBMC-Mild-Myeloid-pDC-pDC-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	PLXNA4 ST6GALNAC4 TTC39A UNC93B1	2.31e-04	188	71	4	879054b780378ae05be68e597c77c931bf0ade03
ToppCell	systemic_lupus_erythematosus-flare-Myeloid-plasmacytoid_dendritic_cell\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	PLXNA4 ST6GALNAC4 TTC39A UNC93B1	2.31e-04	188	71	4	26405ef1b934744e672c642db78834c21d3ba28f
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FNDC3B RNF213 DNAH5 LIX1	2.35e-04	189	71	4	aadb7a2de4cbe7f0958651f2739bba430b93f5c1
ToppCell	PBMC-Mild-Myeloid-pDC\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PLXNA4 ST6GALNAC4 TTC39A UNC93B1	2.35e-04	189	71	4	209cae68d78c8f72479b169e27c3ff7e143adece
ToppCell	3'_v3-lymph-node_spleen-Myeloid_Dendritic-pDC\|lymph-node_spleen / Manually curated celltypes from each tissue	PLXNA4 ST6GALNAC4 TTC39A UNC93B1	2.35e-04	189	71	4	6c2ace61a7d62bcf7e76b73e2da8b722d03e713b
ToppCell	PBMC-Mild-Myeloid-pDC-pDC-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PLXNA4 ST6GALNAC4 TTC39A UNC93B1	2.35e-04	189	71	4	a9ad1fb12304541f909dd0eeac9b9eb28c31fd41
ToppCell	COVID-19_Mild-Myeloid-pDC\|COVID-19_Mild / Disease group, lineage and cell class	PLXNA4 ST6GALNAC4 TTC39A UNC93B1	2.35e-04	189	71	4	c6cfd6aa21c19f2c62d80218bbc924e14e82aada
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FNDC3B RNF213 DNAH5 LIX1	2.35e-04	189	71	4	8977f3295b7df7c7474b3f371de90a82ae4bb50c
ToppCell	Control-Myeloid-pDC\|Control / Disease group, lineage and cell class	PLXNA4 ST6GALNAC4 TTC39A UNC93B1	2.35e-04	189	71	4	46770b99da42f11f10cfc67cea8562342d60b867
ToppCell	PBMC-Mild-Myeloid-pDC-pDC\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PLXNA4 ST6GALNAC4 TTC39A UNC93B1	2.35e-04	189	71	4	98ca646231fbd5f29827c2dd31ac4503026bad7d
ToppCell	3'_v3-bone_marrow-Myeloid_Dendritic-pDC\|bone_marrow / Manually curated celltypes from each tissue	PLXNA4 ST6GALNAC4 TTC39A UNC93B1	2.40e-04	190	71	4	dde0e34f6a06cdbbb65c86472360c09f0279a572
ToppCell	facs-Large_Intestine-Distal\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	B3GNT5 ST6GALNAC4 TTC39A LIX1	2.40e-04	190	71	4	3964a8390522b61b73235151bb0a2ff36b856867
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Ascending_Thin_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FNDC3B PLXNA4 ERMP1 LIX1	2.40e-04	190	71	4	59bbbd2c8d4b7ce46c54ca8022b1557e7e5eee2a
ToppCell	COVID-19_Moderate-pDC\|World / disease group, cell group and cell class	NPC1 ST6GALNAC4 TTC39A UNC93B1	2.45e-04	191	71	4	93adfbc0b22f6006d6d5ad67a99e33cbe9e1dfe9
ToppCell	Control-pDC-\|Control / Disease condition and Cell class	NPC1 PLXNA4 ST6GALNAC4 TTC39A	2.45e-04	191	71	4	1d7b0fae4d114d6db933c18b4eb2066ffa61356d
ToppCell	systemic_lupus_erythematosus-managed-Myeloid-plasmacytoid_dendritic_cell\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	PLXNA4 ST6GALNAC4 TTC39A UNC93B1	2.45e-04	191	71	4	8c487704cbbb5eeff54e8c6fb6fffa1472b5351f
ToppCell	Control-pDC\|Control / Disease condition and Cell class	NPC1 PLXNA4 ST6GALNAC4 TTC39A	2.45e-04	191	71	4	543e1437a52d04436862dd1c27b4fae95c44fcc8
ToppCell	COVID-19_Moderate-pDC\|COVID-19_Moderate / disease group, cell group and cell class	NPC1 ST6GALNAC4 TTC39A UNC93B1	2.45e-04	191	71	4	9d0ffa65c547e20b4076fd97776d7738cbd453ec
ToppCell	systemic_lupus_erythematosus-managed-Myeloid-plasmacytoid_dendritic_cell-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	PLXNA4 ST6GALNAC4 TTC39A UNC93B1	2.45e-04	191	71	4	78d523f562d32fc408a20d99b0c61cc103241bc0
ToppCell	Influenza_Severe-RBC\|Influenza_Severe / Disease group and Cell class	ACSL6 GYPC ST6GALNAC4 TAB3	2.50e-04	192	71	4	f19b6da3fd98da1a76d2570137a8f73a3850ebcb
ToppCell	facs-Large_Intestine-Distal-24m-Epithelial-secretory_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	B3GNT5 ST6GALNAC4 TTC39A LIX1	2.55e-04	193	71	4	64bcdbb422f8da6fc3275e82f6aaf562f546a180
ToppCell	facs-Large_Intestine-Distal-24m-Epithelial-Reg4/cKit+_deep_crypt_secretory_cells_(Distal)\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	B3GNT5 ST6GALNAC4 TTC39A LIX1	2.55e-04	193	71	4	5a92697430f16c49e19a5f727d289d7bd1ece31c
ToppCell	normal-na-Myeloid-plasmacytoid_dendritic_cell-female\|normal / PBMC cell types (v2) per disease, treatment status, and sex	PLXNA4 ST6GALNAC4 TTC39A UNC93B1	2.60e-04	194	71	4	74545942aded51a0f4ee96054b4ce12c4d99a8a0
ToppCell	medial-Hematologic-Plasmacytoid_Dendritic\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	PLXNA4 ST6GALNAC4 TTC39A UNC93B1	2.60e-04	194	71	4	bb36274d6fe2d18c545a17d3809f331586502d01
ToppCell	medial-2-Hematologic-Plasmacytoid_Dendritic\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	PLXNA4 ST6GALNAC4 TTC39A UNC93B1	2.60e-04	194	71	4	d58be6454a0795d6771036a1620553a153861615
ToppCell	medial-Hematologic-Plasmacytoid_Dendritic-2\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	PLXNA4 ST6GALNAC4 TTC39A UNC93B1	2.60e-04	194	71	4	0117cd68750153fd6b8978c8b4ce3589486d2b5f
ToppCell	normal-na-Myeloid-plasmacytoid_dendritic_cell\|normal / PBMC cell types (v2) per disease, treatment status, and sex	PLXNA4 ST6GALNAC4 TTC39A UNC93B1	2.60e-04	194	71	4	c25fc353001cdf9fcd772da5a254c857e555eab8
ToppCell	saliva-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	GYPC UQCC2 ST6GALNAC4 DENND11	2.65e-04	195	71	4	a4d36654b968acb1aea252ac203683939461f1d1
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FNDC3B RNF213 DNAH5 LIX1	2.65e-04	195	71	4	938b31dbf1674ee6fd0123bc88391ddcaf151217
ToppCell	saliva-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	GYPC UQCC2 ST6GALNAC4 DENND11	2.65e-04	195	71	4	cd811abd949ef201aef1c8515da5575ab1b1cfea
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FNDC3B RNF213 DNAH5 LIX1	2.65e-04	195	71	4	d39e9e6544f49e677ebe528c6fe60b99a3630e30
ToppCell	saliva-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell-B_c02-MS4A1-CD27\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	GYPC UQCC2 ST6GALNAC4 DENND11	2.70e-04	196	71	4	0175b097ad1338a07afebe3b5c7fd0bb0bb950f7
ToppCell	facs-Brain_Non-Myeloid-Cortex\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NPC1 ACSL6 ERMP1 LIX1	2.70e-04	196	71	4	256fe9bc0815f66a9afe11ba3507ef1372b52fd3
ToppCell	mild-pDC\|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	PLXNA4 ST6GALNAC4 TTC39A DAAM1	2.75e-04	197	71	4	15230a54fa5903dd728de1a0ad633bd2d2c7a04d
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NPC1 ACSL6 ERMP1 LIX1	2.81e-04	198	71	4	a7e5de81eb7d3d23812c179a001adbaab1506596
ToppCell	severe-pDC\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	PLXNA4 ST6GALNAC4 TTC39A UNC93B1	2.81e-04	198	71	4	22da4a29b9ff8b94d98bc69b4632a2a58d5dd9e6
ToppCell	MS-Multiple_Sclerosis-Myeloid-pDC\|Multiple_Sclerosis / Disease, condition lineage and cell class	NPC1 PLXNA4 ST6GALNAC4 UNC93B1	2.86e-04	199	71	4	c10c8c9322cad4996e4aa11a8680e3d781644ace
ToppCell	Influenza-Influenza_Severe-Others-RBC\|Influenza_Severe / Disease, condition lineage and cell class	ACSL6 GYPC ST6GALNAC4 TAB3	2.86e-04	199	71	4	da0fec0a492bc3827d9066d2590bcd466cd45564
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_\|World / Primary Cells by Cluster	PLXNA4 CHD3 DAAM1 TTLL7	2.86e-04	199	71	4	058373b4ac3cec2108cb24265628ff0a50646e33
ToppCell	Control-Control-Lymphocyte-T/NK-dn_T\|Control / Disease, condition lineage and cell class	BLM ACSL6 GYPC CHD3	2.92e-04	200	71	4	10882c59b7aaf8bd4b5c00aa4ddbb9f7ac5b2cf5
ToppCell	Substantia_nigra-Macroglia-POLYDENDROCYTE-P3-Tnr-Polydendrocyte.Tnr.Cspg5_(Cspg5)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	PKD2L1 PATE2 DNAH5	4.01e-04	90	71	3	3817a5b0235e632d976ea565175bdbebbd959bf0
ToppCell	Substantia_nigra-Macroglia-POLYDENDROCYTE-P3-Tnr-Polydendrocyte.Tnr.Cspg5_(Cspg5)-\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	PKD2L1 PATE2 DNAH5	4.01e-04	90	71	3	a528f5dcee1a356dea89ff2588d2e0f276f2d5fc
Disease	dilated cardiomyopathy 1S (implicated_via_orthology)	MYH1 MYH13	2.40e-04	10	69	2	DOID:0110454 (implicated_via_orthology)
Disease	autosomal dominant hyaline body myopathy (implicated_via_orthology)	MYH1 MYH13	2.40e-04	10	69	2	DOID:0111269 (implicated_via_orthology)
Disease	congenital myopathy 6 (implicated_via_orthology)	MYH1 MYH13	2.40e-04	10	69	2	DOID:0080719 (implicated_via_orthology)
Disease	distal arthrogryposis type 2B3 (implicated_via_orthology)	MYH1 MYH13	2.40e-04	10	69	2	DOID:0111602 (implicated_via_orthology)
Disease	inclusion body myositis (implicated_via_orthology)	MYH1 MYH13	2.40e-04	10	69	2	DOID:3429 (implicated_via_orthology)
Disease	distal arthrogryposis type 2A (implicated_via_orthology)	MYH1 MYH13	2.40e-04	10	69	2	DOID:0111605 (implicated_via_orthology)
Disease	familial hypertrophic cardiomyopathy (implicated_via_orthology)	MYH1 MYH13	2.40e-04	10	69	2	DOID:0080326 (implicated_via_orthology)
Disease	distal arthrogryposis type 1 (implicated_via_orthology)	MYH1 MYH13	2.40e-04	10	69	2	DOID:0111596 (implicated_via_orthology)
Disease	distal myopathy (implicated_via_orthology)	MYH1 MYH13	3.50e-04	12	69	2	DOID:11720 (implicated_via_orthology)
Disease	myotonia congenita (implicated_via_orthology)	MYH1 MYH13	3.50e-04	12	69	2	DOID:2106 (implicated_via_orthology)
Disease	restrictive cardiomyopathy (implicated_via_orthology)	MYH1 MYH13	4.13e-04	13	69	2	DOID:397 (implicated_via_orthology)
Disease	distal arthrogryposis (implicated_via_orthology)	MYH1 MYH13	5.55e-04	15	69	2	DOID:0050646 (implicated_via_orthology)
Disease	partial epilepsy	ELOVL4 SLC33A1	7.16e-04	17	69	2	EFO_0004263
Disease	Immunologic Deficiency Syndromes	BLM C4A	1.32e-03	23	69	2	C0021051
Disease	retinitis pigmentosa (implicated_via_orthology)	PDE6A AGTPBP1	1.82e-03	27	69	2	DOID:10584 (implicated_via_orthology)
Disease	Liver Cirrhosis	NPC1 UNC93B1 F5	1.83e-03	103	69	3	C0023890
Disease	Fibrosis, Liver	NPC1 UNC93B1 F5	1.93e-03	105	69	3	C0239946
Disease	corneal topography	FNDC3B CHSY1 LRRK1	2.15e-03	109	69	3	EFO_0004345

Protein segments in the cluster

Peptide	Gene	Start	Entry
LIKTHNYSMAITYYE	TTC21B	766	Q7Z4L5
LSYALHQVTVYSMYV	SLC33A1	416	O00400
SAAFTLRTQYMKYLY	ARID3B	286	Q8IVW6
TFSHYYYMILSRGQI	C4B	501	P0C0L5
TLTYRNSMYHNKHVF	PRMT8	96	Q9NR22
YQKYSSRTQHAILYM	DHX29	826	Q7Z478
YHYPYTYSTLQMHLQ	AGTPBP1	846	Q9UPW5
IHTLAKRFYYMNASA	ERMP1	506	Q7Z2K6
MTAQHYVTEFNKRLY	ALPK1	1086	Q96QP1
NTFLSCSQYHKMYRT	RAG1	476	P15918
NFYILTRKGQSMYHY	PATE2	61	Q6UY27
KHYITYRINNYTPDM	MMP12	111	P39900
LTNFYQMVQQHRKYY	FAM166C	111	A6NJV1
LVMYHSTTYQLCARY	LRRK1	1761	Q38SD2
QLNSFIHVIMYSYYG	ELOVL4	186	Q9GZR5
YYETTLNLTLDYRMH	GABRQ	121	Q9UN88
THYYLYNRLMDFLTS	HMGXB3	1226	Q12766
RMTSVIAYVYKNHSL	PLXNA4	431	Q9HCM2
MYSLSKGYRKITYHN	PDE6A	546	P16499
MGYFLKLYAYVNSHS	EBLN2	1	Q6P2I7
ALMQQSYNTFKYYSH	TUBGCP6	1771	Q96RT7
KAERSYHIFYQIMSN	MYH1	281	P12882
SYYSQYSLDEKMRSH	LIX1	191	Q8N485
VSYYYIILTIHKMNS	OR2T10	216	Q8NGZ9
YMVDYFKSISQYLHA	NPC1	871	O15118
DNHIVSHMKSYSYRY	B3GNT5	36	Q9BYG0
SHMKSYSYRYLINSY	B3GNT5	41	Q9BYG0
LQAMLHYQKYASERT	DAAM1	241	Q9Y4D1
QVFSMSFNRHNLKYY	BLM	851	P54132
METYVYFYRSHKTQV	DNASE1L1	96	P49184
GVHAIMYTYYTLKAA	ELOVL3	176	Q9HB03
TVNNYRSTKYEMYSK	CENPC	391	Q03188
HSKDIMQTLSRYYSN	FIG4	566	Q92562
SKMYSNVYYHITSKH	CHAMP1	71	Q96JM3
YHTLTNYKAFSQFMR	CHD3	156	Q12873
YHVRVYAMYNSVKGS	FNDC3B	351	Q53EP0
YTLLYRYMHFLENQV	DENND11	161	A4D1U4
MSYIKSNLELYQQYT	C3orf20	1	Q8ND61
NSSVHVIMYLYYGLS	ELOVL1	171	Q9BW60
SLYKSMYFYLHIISL	MBOAT1	451	Q6ZNC8
SYQVYKRYQMVIHKN	ATE1	291	O95260
LRYMYRHKGTYHTNE	GYPC	81	P04921
NMYYNTTSKVKLPYH	ENPP7	96	Q6UWV6
TFSHYYYMILSRGQI	C4A	501	P0C0L4
AIKMIYSISHYYNTS	DNAH5	376	Q8TE73
QMKDLYHYITSYVVD	PSG3	71	Q16557
AYMYYLKHFIHVLQT	UTP20	1651	O75691
LSQESSKYLYMEYHS	TAB3	46	Q8N5C8
SEMYVKSYTIHYSEQ	F5	2146	P12259
YRTLFFRYMSQSKHT	GET4	46	Q7L5D6
LSYLKYAISSQMVSY	MED24	61	O75448
TTYYAQCYRHMLDLQ	SH3GLB2	261	Q9NR46
LNTHYRYIGKTMDYR	MRPL24	91	Q96A35
QMRAIAYHVLAAYYS	URB1	1681	O60287
QIKRGSTYYLHVQSM	SMCR8	836	Q8TEV9
LLTHYYDDARTMYQV	ACSL6	81	Q9UKU0
YQYRLHSYMLSRKIS	CHSY1	311	Q86X52
YQYRLHNYMLSRKIS	CHSY3	401	Q70JA7
VTQKRMEHFYLNFYT	RNF213	1691	Q63HN8
YSHYFQKARDTLYMV	ST6GALNAC4	136	Q9H4F1
YHSLTYDQMLNHYAK	TTLL8	146	A6PVC2
NYITRMAQKYHEYSH	UNC93B1	181	Q9H1C4
FYTGKQSYYSLMHDV	MRPS9	151	P82933
IYQSSHMVDYQPYRK	TEX37	16	Q96LM6
RKDYINAYSHTMSEY	STX18	71	Q9P2W9
MYESLARLHSNYYKH	UQCC2	56	Q9BRT2
SERSYHIFYQIMSNK	MYH13	281	Q9UKX3
NVKFMHNRLQYSLEY	USP9Y	1996	O00507
AYYYTKVMSELFLHT	PKD2L1	126	Q9P0L9
MFSSYAYKSHYLLNE	NSD3	881	Q9BZ95
KFFRYSSYLNSHMRT	ZNF121	151	P58317
YKNYSMESRTHFRIQ	TTC39A	576	Q5SRH9
LTQLYMHLTNYSVNK	TTLL7	241	Q6ZT98
YMNHYTCEKSYRRET	ZNF181	556	Q2M3W8