Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionsulfate adenylyltransferase (ATP) activity

PAPSS2 PAPSS1

3.12e-0521122GO:0004781
GeneOntologyMolecularFunctionsulfate adenylyltransferase activity

PAPSS2 PAPSS1

3.12e-0521122GO:0004779
GeneOntologyMolecularFunctionadenylylsulfate kinase activity

PAPSS2 PAPSS1

3.12e-0521122GO:0004020
GeneOntologyMolecularFunction1-phosphatidylinositol-5-phosphate 4-kinase activity

PIP4K2A PIP4K2B

9.32e-0531122GO:0016309
GeneOntologyMolecularFunctionphosphotransferase activity, alcohol group as acceptor

ERBB2 CAD AXL PAPSS2 PAPSS1 ARAF EDNRA TAOK3 PIP4K2A FER FES PIP4K2B PKN1

1.71e-0470911213GO:0016773
GeneOntologyMolecularFunctiontransferase activity, transferring phosphorus-containing groups

ERBB2 CAD AXL POLE PAPSS2 PAPSS1 ARAF EDNRA TAOK3 PIP4K2A FER FES PIP4K2B PKN1 GDPGP1

2.37e-0493811215GO:0016772
GeneOntologyMolecularFunctionkinase activity

ERBB2 CAD AXL PAPSS2 PAPSS1 ARAF EDNRA TAOK3 PIP4K2A FER FES PIP4K2B PKN1

3.53e-0476411213GO:0016301
GeneOntologyMolecularFunctionDNA nuclease activity

SETMAR POLE RAD1 ENDOG

5.48e-04671124GO:0004536
GeneOntologyBiologicalProcessnegative regulation of insulin receptor signaling pathway

LONP1 KANK1 PIP4K2A PIP4K2B SLC27A4

1.01e-05541105GO:0046627
GeneOntologyBiologicalProcessnegative regulation of cellular response to insulin stimulus

LONP1 KANK1 PIP4K2A PIP4K2B SLC27A4

1.57e-05591105GO:1900077
GeneOntologyBiologicalProcess3'-phosphoadenosine 5'-phosphosulfate biosynthetic process

PAPSS2 PAPSS1

2.82e-0521102GO:0050428
GeneOntologyBiologicalProcesspurine ribonucleoside bisphosphate biosynthetic process

PAPSS2 PAPSS1

2.82e-0521102GO:0034036
GeneOntologyBiologicalProcessendothelin receptor signaling pathway involved in heart process

EDNRA CDC42

8.43e-0531102GO:0086101
GeneOntologyBiologicalProcess1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process

PIP4K2A PIP4K2B

8.43e-0531102GO:1902635
GeneOntologyBiologicalProcessregulation of insulin receptor signaling pathway

LONP1 KANK1 PIP4K2A PIP4K2B SLC27A4

1.34e-04921105GO:0046626
GeneOntologyBiologicalProcessregulation of autophagosome assembly

SH3GLB1 PIP4K2A TBC1D14 PIP4K2B

1.46e-04501104GO:2000785
GeneOntologyBiologicalProcesspositive regulation of autophagosome assembly

SH3GLB1 PIP4K2A PIP4K2B

1.57e-04201103GO:2000786
GeneOntologyBiologicalProcesssulfate assimilation

PAPSS2 PAPSS1

1.68e-0441102GO:0000103
GeneOntologyBiologicalProcess1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolic process

PIP4K2A PIP4K2B

1.68e-0441102GO:1902633
GeneOntologyBiologicalProcessmeiotic recombination checkpoint signaling

HORMAD1 RAD1

1.68e-0441102GO:0051598
GeneOntologyBiologicalProcesssemaphorin-plexin signaling pathway

ERBB2 EDNRA PLXNA4 SEMA3E

1.70e-04521104GO:0071526
GeneOntologyBiologicalProcessinsulin receptor signaling pathway

LONP1 KANK1 PIP4K2A FER PIP4K2B SLC27A4

1.91e-041561106GO:0008286
GeneOntologyBiologicalProcessregulation of cellular response to insulin stimulus

LONP1 KANK1 PIP4K2A PIP4K2B SLC27A4

2.08e-041011105GO:1900076
GeneOntologyBiologicalProcesssympathetic nervous system development

ERBB2 EDNRA PLXNA4

2.75e-04241103GO:0048485
GeneOntologyBiologicalProcesssympathetic neuron axon guidance

EDNRA PLXNA4

2.79e-0451102GO:0097492
GeneOntologyBiologicalProcesspositive regulation of vacuole organization

SH3GLB1 PIP4K2A PIP4K2B

3.12e-04251103GO:0044090
GeneOntologyBiologicalProcessregulation of vacuole organization

SH3GLB1 PIP4K2A TBC1D14 PIP4K2B

3.16e-04611104GO:0044088
GeneOntologyBiologicalProcesscell-substrate adhesion

ITGA11 RASA1 AXL ECM2 ITGA9 KANK1 FER CDC42 SEMA3E

3.51e-044101109GO:0031589
GeneOntologyBiologicalProcessribonucleotide biosynthetic process

CAD ACACA PAPSS2 PAPSS1 MTHFD1 SDHA PNP

3.62e-042471107GO:0009260
GeneOntologyBiologicalProcessregulation of plasma membrane bounded cell projection assembly

CYLD DPYSL3 KANK1 TBC1D14 FER CDC42 AGRN

3.71e-042481107GO:0120032
GeneOntologyBiologicalProcessregulation of cell projection assembly

CYLD DPYSL3 KANK1 TBC1D14 FER CDC42 AGRN

3.99e-042511107GO:0060491
GeneOntologyBiologicalProcessribose phosphate biosynthetic process

CAD ACACA PAPSS2 PAPSS1 MTHFD1 SDHA PNP

4.18e-042531107GO:0046390
DomainPUA-like_domain

PAPSS2 PAPSS1 LONP1 NIP7

3.69e-06191074IPR015947
DomainSulfurylase_cat_dom

PAPSS2 PAPSS1

3.25e-0521072IPR024951
DomainATP-sulfurylase

PAPSS2 PAPSS1

3.25e-0521072PF01747
DomainPUA_2

PAPSS2 PAPSS1

3.25e-0521072PF14306
DomainAPS_kinase

PAPSS2 PAPSS1

3.25e-0521072IPR002891
DomainSulphate_adenylyltransferase

PAPSS2 PAPSS1

3.25e-0521072IPR002650
DomainATP-Sase_PUA-like_dom

PAPSS2 PAPSS1

3.25e-0521072IPR025980
DomainTyr-prot_kinase_Fes/Fps

FER FES

3.25e-0521072IPR016250
DomainFG_GAP

ITGA11 ITGA9 ITFG1

2.60e-04221073PS51470
DomainHistone_H2A

MACROH2A1 H2AC18 H2AC20

2.98e-04231073IPR002119
DomainH2A

MACROH2A1 H2AC18 H2AC20

2.98e-04231073SM00414
DomainCPSASE_1

CAD ACACA

3.22e-0451072PS00866
DomainFG-GAP

ITGA11 ITGA9 ITFG1

3.39e-04241073PF01839
DomainFG-GAP

ITGA11 ITGA9 ITFG1

3.39e-04241073IPR013517
DomainCPSASE_2

CAD ACACA

4.80e-0461072PS00867
DomainPInositol-4-P-5-kinase

PIP4K2A PIP4K2B

6.70e-0471072IPR023610
DomainCbamoylP_synth_lsu-like_ATP-bd

CAD ACACA

6.70e-0471072IPR005479
DomainBC-like_N

CAD ACACA

6.70e-0471072IPR005481
DomainCPSase_L_D2

CAD ACACA

6.70e-0471072PF02786
DomainBiotin_carb_N

CAD ACACA

6.70e-0471072PF00289
DomainPkinase_Tyr

ERBB2 AXL ARAF FER FES

8.81e-041291075PF07714
DomainPIPKc

PIP4K2A PIP4K2B

8.90e-0481072SM00330
Domain-

PIP4K2A PIP4K2B

8.90e-04810723.30.800.10
DomainPIP5K

PIP4K2A PIP4K2B

8.90e-0481072PF01504
DomainPIPK

PIP4K2A PIP4K2B

8.90e-0481072PS51455
DomainPInositol-4-P-5-kinase_N

PIP4K2A PIP4K2B

8.90e-0481072IPR027484
DomainPInositol-4-P-5-kinase_C

PIP4K2A PIP4K2B

8.90e-0481072IPR027483
Domain-

PIP4K2A PIP4K2B

8.90e-04810723.30.810.10
DomainPInositol-4-P-5-kinase_core

PIP4K2A PIP4K2B

8.90e-0481072IPR002498
DomainSer-Thr/Tyr_kinase_cat_dom

ERBB2 AXL ARAF FER FES

1.19e-031381075IPR001245
DomainAmidohydro_1

DPYSL3 CAD

1.42e-03101072PF01979
DomainMetal-dep_hydrolase_composite

DPYSL3 CAD

1.42e-03101072IPR011059
DomainTyr_kinase_cat_dom

ERBB2 AXL FER FES

1.64e-03881074IPR020635
DomainTyrKc

ERBB2 AXL FER FES

1.64e-03881074SM00219
DomainAmidohydro-rel

DPYSL3 CAD

1.73e-03111072IPR006680
DomainPROTEIN_KINASE_TYR

ERBB2 AXL FER FES

2.34e-03971074PS00109
DomainTyr_kinase_AS

ERBB2 AXL FER FES

2.34e-03971074IPR008266
Domain-

CAD ACACA

2.43e-031310723.40.50.20
DomainHEAT

RANBP6 PPP2R1B MROH1

2.62e-03481073PF02985
DomainDynein_heavy_chain_D4_dom

DNAH7 DNAH8

2.83e-03141072IPR024317
DomainDynein_HC_stalk

DNAH7 DNAH8

2.83e-03141072IPR024743
DomainDynein_heavy_dom-2

DNAH7 DNAH8

2.83e-03141072IPR013602
DomainDHC_N2

DNAH7 DNAH8

2.83e-03141072PF08393
DomainATP_GRASP

CAD ACACA

2.83e-03141072PS50975
DomainATP-grasp

CAD ACACA

2.83e-03141072IPR011761
DomainPreATP-grasp_dom

CAD ACACA

2.83e-03141072IPR016185
DomainMT

DNAH7 DNAH8

2.83e-03141072PF12777
DomainAAA_8

DNAH7 DNAH8

2.83e-03141072PF12780
DomainDHC_fam

DNAH7 DNAH8

3.25e-03151072IPR026983
DomainDynein_heavy

DNAH7 DNAH8

3.25e-03151072PF03028
DomainDynein_heavy_dom

DNAH7 DNAH8

3.25e-03151072IPR004273
Domain-

CAD ACACA

3.25e-031510723.30.1490.20
DomainHistone_H2A/H2B/H3

MACROH2A1 H2AC18 H2AC20

4.07e-03561073IPR007125
DomainHistone

MACROH2A1 H2AC18 H2AC20

4.07e-03561073PF00125
DomainAminotran_1_2

SPTLC2 GOT1L1

4.18e-03171072PF00155
DomainAminotransferase_I/II

SPTLC2 GOT1L1

4.18e-03171072IPR004839
DomainHEAT_type_2

PPP2R1B MROH1

4.18e-03171072IPR021133
DomainHistone_H2A_C

MACROH2A1 H2AC20

4.18e-03171072IPR032454
DomainHistone_H2A_C

MACROH2A1 H2AC20

4.18e-03171072PF16211
DomainCA

PCDHGA6 PCDHB10 FREM2 CDH18

4.33e-031151074SM00112
DomainHEAT

RANBP6 PPP2R1B MROH1

4.49e-03581073IPR000357
DomainIntegrin_alpha-2

ITGA11 ITGA9

4.69e-03181072IPR013649
DomainATP_grasp_subdomain_1

CAD ACACA

4.69e-03181072IPR013815
DomainNA_NEUROTRAN_SYMP_2

SLC6A7 SLC6A11

4.69e-03181072PS00754
Domain-

CAD ACACA

4.69e-031810723.30.470.20
DomainINTEGRIN_ALPHA

ITGA11 ITGA9

4.69e-03181072PS00242
DomainIntegrin_alpha2

ITGA11 ITGA9

4.69e-03181072PF08441
DomainIntegrin_alpha

ITGA11 ITGA9

4.69e-03181072IPR000413
DomainCadherin

PCDHGA6 PCDHB10 FREM2 CDH18

4.74e-031181074IPR002126
DomainSNF

SLC6A7 SLC6A11

5.22e-03191072PF00209
DomainInt_alpha

ITGA11 ITGA9

5.22e-03191072SM00191
DomainNa/ntran_symport

SLC6A7 SLC6A11

5.22e-03191072IPR000175
DomainInt_alpha_beta-p

ITGA11 ITGA9

5.22e-03191072IPR013519
DomainNA_NEUROTRAN_SYMP_1

SLC6A7 SLC6A11

5.22e-03191072PS00610
DomainNA_NEUROTRAN_SYMP_3

SLC6A7 SLC6A11

5.22e-03191072PS50267
PathwayREACTOME_SEMAPHORIN_INTERACTIONS

ERBB2 DPYSL3 PLXNA4 FES SEMA3E

1.34e-0551855MM14967
PathwayREACTOME_SEMAPHORIN_INTERACTIONS

ERBB2 DPYSL3 PLXNA4 FES SEMA3E

4.08e-0564855M7923
PathwayREACTOME_CRMPS_IN_SEMA3A_SIGNALING

DPYSL3 PLXNA4 FES

9.14e-0515853MM15031
PathwayKEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM

ACO1 MTHFD1 PGP

1.12e-0416853M5244
PathwayREACTOME_CRMPS_IN_SEMA3A_SIGNALING

DPYSL3 PLXNA4 FES

1.12e-0416853M8245
PathwayWP_SULFATION_BIOTRANSFORMATION_REACTION

PAPSS2 PAPSS1 SULT4A1

1.35e-0417853M39483
PathwayREACTOME_NERVOUS_SYSTEM_DEVELOPMENT

ERBB2 DPYSL3 RASA1 ITGA9 PLXNA4 FES CDC42 SEMA3E

1.74e-04261858MM15676
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

CAD ACACA SPTLC2 POLE SMCHD1 PSMB2 U2AF2 MACROH2A1 SSRP1 PAPSS2 SMG8 LONP1 MTHFD1 PIP4K2A PGP AGRN SLC27A4 PNP HDLBP

7.47e-0813531131929467282
Pubmed

Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.

PDPR ACACA SPTLC2 AXL TM9SF1 FKBP9 POMGNT1 GFM2 LONP1 TAOK3 CLCN5 PIP4K2A PIP4K2B CATSPERG AGRN SDHA SLC27A4 PNP HDLBP

2.19e-0714511131930550785
Pubmed

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.

CEL AXL ACO1 PSMB2 MACROH2A1 PLA2G15 ITFG1 PEBP4 FREM2 PPP2R1B H2AC18 H2AC20 MTHFD1 CDC42 AGRN PNP

3.91e-0710701131623533145
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

CAD ACACA POLE SMCHD1 PSMB2 U2AF2 MACROH2A1 SSRP1 PLA2G15 LONP1 GUCY1B2 MTHFD1 FGD5 CDC42 HNRNPLL SDHA SLC27A4 HDLBP

7.99e-0714251131830948266
Pubmed

Transcription through the HIV-1 nucleosomes: effects of the PBAF complex in Tat activated transcription.

SSRP1 H2AC18 H2AC20

1.85e-068113320599239
Pubmed

Expression of tyrosine kinase gene in mouse thymic stromal cells.

AXL FER FES

3.94e-061011338943574
Pubmed

HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.

DPYSL3 CAD ACACA SMCHD1 SSRP1 ARAF SORCS1 CACNA1G FGD5 PGP SDHA HDLBP

6.62e-067541131235906200
Pubmed

Biochemical Reduction of the Topology of the Diverse WDR76 Protein Interactome.

CAD MACROH2A1 FREM2 LONP1 H2AC18 HNRNPLL AGRN

7.82e-06219113731353912
Pubmed

A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.

ERBB2 U2AF2 SSRP1 DNAH7 SLC3A1 LONP1 H2AC18 TRPM3 DNAH8

9.90e-06420113928065597
Pubmed

Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation.

CAD ACACA SMCHD1 PSMB2 PAPSS1 LONP1 H2AC20 MTHFD1 PGP HDLBP

1.01e-055341131035032548
Pubmed

Fer kinase limits neutrophil chemotaxis toward end target chemoattractants.

FER FES

1.05e-052113223355730
Pubmed

A member of a family of sulfate-activating enzymes causes murine brachymorphism.

PAPSS2 PAPSS1

1.05e-05211329671738
Pubmed

Promotion of glioblastoma cell motility by enhancer of zeste homolog 2 (EZH2) is mediated by AXL receptor kinase.

AXL EZH2

1.05e-052113223077658
Pubmed

Fps/Fes and Fer non-receptor protein-tyrosine kinases regulate collagen- and ADP-induced platelet aggregation.

FER FES

1.05e-052113212871378
Pubmed

Closing in on the biological functions of Fps/Fes and Fer.

FER FES

1.05e-052113211994747
Pubmed

Regulation of Breast Cancer-Induced Osteoclastogenesis by MacroH2A1.2 Involving EZH2-Mediated H3K27me3.

MACROH2A1 EZH2

1.05e-052113229972783
Pubmed

Nuclear localization of PAPS synthetase 1: a sulfate activation pathway in the nucleus of eukaryotic cells.

PAPSS2 PAPSS1

1.05e-052113210657990
Pubmed

FER and FES tyrosine kinase fusions in follicular T-cell lymphoma.

FER FES

1.05e-052113231746983
Pubmed

Human 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 (PAPSS1) and PAPSS2: gene cloning, characterization and chromosomal localization.

PAPSS2 PAPSS1

1.05e-052113210679223
Pubmed

Characterization and expression of human bifunctional 3'-phosphoadenosine 5'-phosphosulphate synthase isoforms.

PAPSS2 PAPSS1

1.05e-052113211931637
Pubmed

Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy.

PIP4K2A PIP4K2B

1.05e-052113229727621
Pubmed

Human PAPS synthase isoforms are dynamically regulated enzymes with access to nucleus and cytoplasm.

PAPSS2 PAPSS1

1.05e-052113222242175
Pubmed

The atypical histone macroH2A1.2 interacts with HER-2 protein in cancer cells.

ERBB2 MACROH2A1

1.05e-052113222589551
Pubmed

Fps/Fes and Fer protein-tyrosinekinases play redundant roles in regulating hematopoiesis.

FER FES

1.05e-052113212901971
Pubmed

Mutations in orthologous genes in human spondyloepimetaphyseal dysplasia and the brachymorphic mouse.

PAPSS2 PAPSS1

1.05e-05211329771708
Pubmed

Conservation of notochord gene expression across chordates: insights from the Leprecan gene family.

PAPSS2 PAPSS1 AGRN

1.18e-0514113318798549
Pubmed

FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2.

ERBB2 CAD U2AF2 SSRP1 PAPSS2 PAPSS1 LONP1 MTHFD1 ENDOG HDLBP

2.78e-056011131033658012
Pubmed

SARS-CoV-2 uses Spike glycoprotein to control the host's anaerobic metabolism by inhibiting LDHB.

ERBB2 U2AF2 MACROH2A1 SSRP1 PAPSS1 LONP1 MTHFD1 CDC42 SDHA HDLBP

3.02e-056071131039147351
Pubmed

Functional analysis of the biochemical activity of mammalian phosphatidylinositol 5 phosphate 4-kinase enzymes.

PIP4K2A PIP4K2B

3.13e-053113230718367
Pubmed

EZH2-mediated PP2A inactivation confers resistance to HER2-targeted breast cancer therapy.

ERBB2 EZH2

3.13e-053113233208750
Pubmed

The Fer tyrosine kinase regulates an axon retraction response to Semaphorin 3A in dorsal root ganglion neurons.

FER FES

3.13e-053113218053124
Pubmed

The function of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) explored using a specific inhibitor that targets the PI5P-binding site.

PIP4K2A PIP4K2B

3.13e-053113225495341
Pubmed

Evolutionarily conserved structural changes in phosphatidylinositol 5-phosphate 4-kinase (PI5P4K) isoforms are responsible for differences in enzyme activity and localization.

PIP4K2A PIP4K2B

3.13e-053113223758345
Pubmed

The adaptor protein Nck1 mediates endothelin A receptor-regulated cell migration through the Cdc42-dependent c-Jun N-terminal kinase pathway.

EDNRA CDC42

3.13e-053113215187089
Pubmed

ERBB2 drives YAP activation and EMT-like processes during cardiac regeneration.

ERBB2 A1CF

3.13e-053113233046882
Pubmed

The Lipid Kinase PI5P4Kβ Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis.

PIP4K2A PIP4K2B

3.13e-053113226774281
Pubmed

Phosphorylation of the ras GTPase-activating protein (GAP) by the p93c-fes protein-tyrosine kinase in vitro and formation of GAP-fes complexes via an SH2 domain-dependent mechanism.

RASA1 FES

3.13e-05311327691175
Pubmed

Characterization of functionally independent domains in the human ubiquitin conjugating enzyme UbcH2.

H2AC18 H2AC20

3.13e-05311328543049
Pubmed

PDGFR-β Signaling Regulates Cardiomyocyte Proliferation and Myocardial Regeneration.

A1CF EZH2

3.13e-053113231340157
Pubmed

Essential role of sympathetic endothelin A receptors for adverse cardiac remodeling.

EDNRA CDC42

3.13e-053113225197047
Pubmed

Decreased cardiac L-type Ca²⁺ channel activity induces hypertrophy and heart failure in mice.

A1CF CACNA1G

3.13e-053113222133878
Pubmed

[Effects of cocaine on activities of ATPase, LDH and SDH in mouse splenocytes].

DNAH8 SDHA

3.13e-053113220653129
Pubmed

Epigenetic modifiers DNMT3A and BCOR are recurrently mutated in CYLD cutaneous syndrome.

CYLD BCOR

3.13e-053113231624251
Pubmed

Genomic Alterations of NTRK, POLE, ERBB2, and Microsatellite Instability Status in Chinese Patients with Colorectal Cancer.

ERBB2 POLE

3.13e-053113232627883
Pubmed

Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53-null tumors.

PIP4K2A PIP4K2B

3.13e-053113224209622
Pubmed

Mitochondrial matrix proteostasis is linked to hereditary paraganglioma: LON-mediated turnover of the human flavinylation factor SDH5 is regulated by its interaction with SDHA.

LONP1 SDHA

3.13e-053113224414418
Pubmed

Pharmacological inhibition of PI5P4Kα/β disrupts cell energy metabolism and selectively kills p53-null tumor cells.

PIP4K2A PIP4K2B

3.13e-053113234001596
Pubmed

Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.

ERBB2 PDPR SPTLC2 AXL ACO1 SMCHD1 TM9SF1 POMGNT1 RANBP6 MROH1 MTHFD1 PKN1 MMP15

4.23e-0510611131333845483
Pubmed

A protein interaction landscape of breast cancer.

ERBB2 SPTLC2 ACO1 MACROH2A1 SSRP1 EZH2 ARAF LONP1 SLC27A4 HDLBP

4.36e-056341131034591612
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

POLE EZH2 PAPSS2 ARAF SMG8 FREM2 TAOK3 AGRN SLC27A4 SEMA3E

5.36e-056501131038777146
Pubmed

Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.

CAD ACACA PSMB2 U2AF2 SSRP1 PAPSS1 ARAF LONP1 KANK1 MTHFD1 CDC42 HNRNPLL SDHA HDLBP

5.43e-0512471131427684187
Pubmed

A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate.

PIP4K2A PIP4K2B

6.25e-05411329367159
Pubmed

PI5P4Ks drive metabolic homeostasis through peroxisome-mitochondria interplay.

PIP4K2A PIP4K2B

6.25e-054113233984270
Pubmed

Downregulation of the acetyl-CoA metabolic network in adipose tissue of obese diabetic individuals and recovery after weight loss.

ACACA MTHFD1

6.25e-054113225099943
Pubmed

UMI, a novel RNF168 ubiquitin binding domain involved in the DNA damage signaling pathway.

H2AC18 H2AC20

6.25e-054113221041483
Pubmed

CRMP4-mediated fornix development involves Semaphorin-3E signaling pathway.

DPYSL3 SEMA3E

6.25e-054113234860155
Pubmed

Rho family GTPases bind to phosphoinositide kinases.

PIP4K2A CDC42

6.25e-05411327629060
Pubmed

PIP4Ks Suppress Insulin Signaling through a Catalytic-Independent Mechanism.

PIP4K2A PIP4K2B

6.25e-054113231091439
Pubmed

RAFTK/Pyk2 tyrosine kinase mediates the association of p190 RhoGAP with RasGAP and is involved in breast cancer cell invasion.

ERBB2 RASA1

6.25e-054113210713673
Pubmed

The histone variant macroH2A is an epigenetic regulator of key developmental genes.

MACROH2A1 EZH2

6.25e-054113219734898
Pubmed

Knockdown of CTCF reduces the binding of EZH2 and affects the methylation of the SOCS3 promoter in hepatocellular carcinoma.

EZH2 HDLBP

6.25e-054113231917284
Pubmed

HER2/ErbB2-induced breast cancer cell migration and invasion require p120 catenin activation of Rac1 and Cdc42.

ERBB2 CDC42

6.25e-054113220595387
Pubmed

The Receptor Tyrosine Kinase AXL Is Required at Multiple Steps of the Metastatic Cascade during HER2-Positive Breast Cancer Progression.

ERBB2 AXL

6.25e-054113229719259
Pubmed

Up-regulation of acetyl-CoA carboxylase alpha and fatty acid synthase by human epidermal growth factor receptor 2 at the translational level in breast cancer cells.

ERBB2 ACACA

6.25e-054113217631500
Pubmed

Mitochondrial antiviral-signalling protein is a client of the BAG6 protein quality control complex.

AXL SMCHD1 U2AF2

6.43e-0524113335543156
Pubmed

Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.

CAD ACACA ACO1 PSMB2 U2AF2 PAPSS2 MTHFD1 CACNA1G CDC42 PNP HDLBP

6.66e-058071131130575818
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

PCDHGA6 SMCHD1 U2AF2 MACROH2A1 SSRP1 H2AC18 H2AC20 CLCN5 NAA20 PIP4K2A NIP7 PLXNA4 PIP4K2B DNAH8 SLC27A4

6.83e-0514421131535575683
Pubmed

A high-throughput approach for measuring temporal changes in the interactome.

DPYSL3 ACACA ACO1 PSMB2 FKBP9 RANBP6 SSRP1 PAPSS2 PAPSS1 PPP2R1B SH3GLB1 MTHFD1 CDC42 PNP HDLBP

7.55e-0514551131522863883
Pubmed

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.

CYLD CAD ACACA MACROH2A1 SLC6A11 LONP1 H2AC18 MTHFD1 PIP4K2B CDC42 HNRNPLL SDHA HDLBP

8.65e-0511391131336417873
Pubmed

Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS.

CAD ACACA USP9Y PPP2R1B LONP1 PIP4K2A PIP4K2B CDC42

8.72e-05432113823455922
Pubmed

Proteomic and Interactome Approaches Reveal PAK4, PHB-2, and 14-3-3η as Targets of Overactivated Cdc42 in Cellular Responses to Genomic Instability.

ACO1 U2AF2 LONP1 CDC42 SDHA HDLBP

9.74e-05225113631478661
Pubmed

BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.

CAD ACACA SMCHD1 U2AF2 MACROH2A1 SSRP1 LONP1 TAOK3 MTHFD1 PIP4K2A NIP7 PIP4K2B AGRN SDHA

9.76e-0513181131430463901
Pubmed

The ubiquitin E3 ligase ARIH1 regulates hnRNP E1 protein stability, EMT and breast cancer progression.

CYLD MACROH2A1 PKN1 HDLBP

1.02e-0474113435102251
Pubmed

KAP1 facilitates reinstatement of heterochromatin after DNA replication.

CAD PDPR ACACA POLE U2AF2 SSRP1 NIP7 CDC42 DNAH8 HNRNPLL

1.04e-047041131029955894
Pubmed

Neuregulin1/ErbB4 signaling induces cardiomyocyte proliferation and repair of heart injury.

ERBB2 A1CF

1.04e-045113219632177
Pubmed

Histone chaperone FACT coordinates nucleosome interaction through multiple synergistic binding events.

SSRP1 H2AC20

1.04e-045113221969370
Pubmed

Distribution and localization of phosphatidylinositol 5-phosphate, 4-kinase alpha and beta in the brain.

PIP4K2A PIP4K2B

1.04e-045113232449185
Pubmed

Kank attenuates actin remodeling by preventing interaction between IRSp53 and Rac1.

KANK1 CDC42

1.04e-045113219171758
Pubmed

Recognition of UbcH5c and the nucleosome by the Bmi1/Ring1b ubiquitin ligase complex.

H2AC18 H2AC20

1.04e-045113221772249
Pubmed

Expression profile of Papss2 (3'-phosphoadenosine 5'-phosphosulfate synthase 2) during cartilage formation and skeletal development in the mouse embryo.

PAPSS2 PAPSS1

1.04e-045113217436279
Pubmed

Regulation of cell cycle progression and gene expression by H2A deubiquitination.

H2AC18 H2AC20

1.04e-045113217914355
Pubmed

Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.

CAD PSMB2 RANBP6 U2AF2 MACROH2A1 SSRP1 BCOR PPP2R1B LONP1 MTHFD1 CDC42 HNRNPLL SDHA HDLBP

1.12e-0413351131429229926
Pubmed

Proteome-wide analysis of USP14 substrates revealed its role in hepatosteatosis via stabilization of FASN.

SMCHD1 PSMB2 U2AF2 MACROH2A1 SSRP1 MTHFD1 HDLBP

1.14e-04334113730425250
Pubmed

Comprehensive binary interaction mapping of SH2 domains via fluorescence polarization reveals novel functional diversification of ErbB receptors.

ERBB2 RASA1 FER FES

1.19e-0477113422973453
Pubmed

Neuregulin-1 potentiates agrin-induced acetylcholine receptor clustering through muscle-specific kinase phosphorylation.

ERBB2 AGRN

1.56e-046113222328506
Pubmed

Regulation of IRSp53-dependent filopodial dynamics by antagonism between 14-3-3 binding and SH3-mediated localization.

ARAF CDC42

1.56e-046113219933840
Pubmed

Branches of the B cell antigen receptor pathway are directed by protein conduits Bam32 and Carma1.

PIP4K2A PIP4K2B

1.56e-046113214614850
Pubmed

Control of vesicle fusion by a tyrosine phosphatase.

FER FES

1.56e-046113215322554
Pubmed

Fer and Fps/Fes participate in a Lyn-dependent pathway from FcepsilonRI to platelet-endothelial cell adhesion molecule 1 to limit mast cell activation.

FER FES

1.56e-046113216731527
Pubmed

Oligomerization but Not Membrane Bending Underlies the Function of Certain F-BAR Proteins in Cell Motility and Cytokinesis.

FER FES

1.56e-046113226702831
Pubmed

AMPK regulates cell shape of cardiomyocytes by modulating turnover of microtubules through CLIP-170.

A1CF ACACA

1.56e-046113233251722
Pubmed

Impact of combinatorial dysfunctions of Tet2 and Ezh2 on the epigenome in the pathogenesis of myelodysplastic syndrome.

BCOR EZH2

1.56e-046113227694924
Pubmed

Ring1b-mediated H2A ubiquitination associates with inactive X chromosomes and is involved in initiation of X inactivation.

H2AC18 H2AC20

1.56e-046113215509584
Pubmed

PKNbeta interacts with the SH3 domains of Graf and a novel Graf related protein, Graf2, which are GTPase activating proteins for Rho family.

PKN1 CDC42

1.56e-046113211432776
Pubmed

Characterization of a novel giant scaffolding protein, CG-NAP, that anchors multiple signaling enzymes to centrosome and the golgi apparatus.

PPP2R1B PKN1

1.56e-046113210358086
Pubmed

The protein tyrosine kinase family of the human genome.

ERBB2 AXL FER FES

1.59e-0483113411114734
Pubmed

A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.

ANKRD13D ACACA U2AF2 MACROH2A1 BCOR PIP4K2B CACNA1G HNRNPLL AGRN

1.71e-04608113916713569
Pubmed

PINK1 Content in Mitochondria is Regulated by ER-Associated Degradation.

CAD ACACA ARAF H2AC18 H2AC20 MTHFD1 SDHA HDLBP

1.72e-04477113831300519
Pubmed

Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.

CAD ACACA SMCHD1 PSMB2 U2AF2 SSRP1 PAPSS2 LONP1 H2AC20 MTHFD1 NIP7 PGP SDHA HDLBP

2.04e-0414151131428515276
Pubmed

ARMC5 is part of an RPB1-specific ubiquitin ligase implicated in adrenal hyperplasia.

CAD ARAF LONP1 MTHFD1 SDHA

2.16e-04166113535687106
InteractionPABPC1 interactions

CYLD ERBB2 AXL POLE U2AF2 SSRP1 EZH2 ARAF ITFG1 LONP1 MROH1 PCSK7 FGD5 AGRN HDLBP

6.03e-0669911015int:PABPC1
InteractionTUBB interactions

CYLD DPYSL3 CAD PSMB2 U2AF2 MACROH2A1 EZH2 ARAF ITFG1 SMG8 NIP7 PKN1 FGD5 CDC42 AGRN

1.10e-0573511015int:TUBB
InteractionJUP interactions

CYLD ERBB2 DPYSL3 CAD RASA1 AXL EZH2 ARAF PTPRQ FER CDC42 SDHA

1.37e-0548511012int:JUP
InteractionAHCY interactions

CYLD SMCHD1 EZH2 PAPSS2 PAPSS1 ITFG1 MTHFD1 FGD5 HDLBP

3.30e-052931109int:AHCY
InteractionDNAJA1 interactions

CYLD ERBB2 CAD ACACA AXL U2AF2 MACROH2A1 EZH2 ARAF ITFG1 LONP1 ENDOG

3.46e-0553311012int:DNAJA1
InteractionTRPM1 interactions

BCOR EZH2 HDLBP

4.35e-05131103int:TRPM1
InteractionH2AC12 interactions

CYLD MACROH2A1 EZH2 ARAF H2AC18 H2AC20

4.63e-051181106int:H2AC12
InteractionWDR76 interactions

CAD SMCHD1 MACROH2A1 SSRP1 EZH2 FREM2 LONP1 H2AC18 HNRNPLL AGRN

4.74e-0538311010int:WDR76
InteractionRFC3 interactions

CYLD SSRP1 EZH2 ITFG1 RAD1 CDC42 AGRN

5.32e-051771107int:RFC3
InteractionCLTC interactions

CYLD ERBB2 CAD ACO1 RANBP6 U2AF2 EZH2 PPP2R1B MTHFD1 FGD5 CDC42 AGRN HDLBP

5.89e-0565511013int:CLTC
InteractionITGB1 interactions

CYLD ERBB2 ITGA11 ACACA AXL ITGA9 EZH2 TAOK3 CDC42 DNAH8

6.81e-0540011010int:ITGB1
InteractionH2BC12 interactions

CYLD MYO1H SMCHD1 MACROH2A1 EZH2 ARAF H2AC18 H2AC20 CLCN5

6.85e-053221109int:H2BC12
InteractionH2AJ interactions

U2AF2 MACROH2A1 SSRP1 H2AC18 H2AC20 HNRNPLL

6.98e-051271106int:H2AJ
InteractionOR7A10 interactions

OR7A10 SDHA

8.83e-0531102int:OR7A10
InteractionNSFL1C interactions

CYLD PSMB2 EZH2 PAPSS1 LONP1 CDC42 AGRN

8.89e-051921107int:NSFL1C
InteractionENO1 interactions

CYLD PDPR ACACA ACO1 SSRP1 EZH2 ARAF KANK1 FGD5 DNAH8 AGRN PNP HDLBP

1.16e-0470111013int:ENO1
InteractionSEPTIN6 interactions

ERBB2 AXL EZH2 CDC42 HDLBP

1.21e-04881105int:SEPTIN6
InteractionFNDC5 interactions

PDPR ACACA SPTLC2 AXL TM9SF1 FKBP9 POMGNT1 MACROH2A1 GFM2 LONP1 H2AC20 TAOK3 CLCN5 PIP4K2A PIP4K2B AGRN SDHA SLC27A4 PNP HDLBP

1.24e-04147011020int:FNDC5
InteractionPCDHB3 interactions

SPTLC2 AXL PCDHB10 ITFG1 SMG8 MMP15

1.24e-041411106int:PCDHB3
InteractionMTHFD1 interactions

CYLD U2AF2 EZH2 PAPSS2 ITFG1 MTHFD1 AGRN HDLBP

1.48e-042791108int:MTHFD1
CoexpressionHAHTOLA_SEZARY_SYNDROM_UP

PSMB2 EZH2 PAPSS1 H2AC18 SH3GLB1 PNP

4.31e-06991126M14577
CoexpressionIL21_UP.V1_DN

A1CF CEL USP9Y DNAH7 GUCY1B2 SLC16A2 FES

1.57e-051861127M2824
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DNAH7 SORCS1 SLC6A7 TRPM3 PLXNA4 TESC CDH18

4.86e-0718411476475a43201b136dcc9b113d2ca4cfa154ed9d65d
ToppCell(6)_ILC|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)

TNFRSF25 DPYSL3 MPV17L ACY3 MACROH2A1 SORCS1 FES

5.61e-071881147de7cb273899d0e0748c85f45c6b5e7f0642ab057
ToppCell(6)_ILC|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)

TNFRSF25 DPYSL3 MPV17L ACY3 MACROH2A1 SORCS1 FES

5.61e-071881147f4734d5b703678670ece204a0519cf015e180a6e
ToppCellfacs-Lung-Endomucin-24m-Endothelial-Capillary_Type_1_Cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

A1CF POLE USP9Y SLC6A11 FREM2 PTPRQ

2.02e-06145114696712c68ab759d7ade0d912581a1a7c25dc6def8
ToppCellfacs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

A1CF POLE USP9Y SLC6A11 FREM2 PTPRQ

3.84e-061621146bf886e22ff2a20353499004b53f25fb9e6574896
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PAPSS2 SORCS1 SLC6A7 TRPM3 TESC CDH18

7.03e-0618011465391d23817f5cc88a0871ddb98968897c839f464
ToppCellLPS-antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ERBB2 ITGA9 TRPM3 PTPRQ AGRN SEMA3E

7.26e-061811146b45b11428d13950369347e051d4d517efb2bd4fd
ToppCellfacs-Lung-nan-3m-Mesenchymal-pulmonary_interstitial_fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ECM2 ITGA9 EDNRA SORCS1 CACNA1G SEMA3E

9.57e-061901146c7bd087f36321cec61b98657433b4d19d135791f
ToppCellfacs-Lung-nan-3m-Mesenchymal-Myofibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ECM2 ITGA9 EDNRA SORCS1 CACNA1G SEMA3E

9.57e-061901146834218fcc59df5e7e52de154272f3d55d81d0dac
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DNAH7 SLC3A1 FREM2 KANK1 CLCN5 TRPM3

1.08e-05194114693c68c31e39fa44c1d05d7d4997f4f086da4e738
ToppCellILEUM-inflamed-(6)_ILC|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

TNFRSF25 MPV17L MACROH2A1 SORCS1 PIP4K2A FES

1.08e-0519411464d51d49366c34ff1241770b4acc0167a43b3155a
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PAPSS2 SORCS1 SLC6A7 TRPM3 PLXNA4 CDH18

1.11e-051951146787e95fb59c40bba784544b662fac37606ae1427
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA11 DPYSL3 AXL ECM2 ITGA9 EDNRA

1.14e-0519611461522958a92e0126326a9f0d9fb1c5b5c50b001ea
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA11 DPYSL3 AXL ECM2 ITGA9 EDNRA

1.14e-0519611461c8294014713684b50885e638668f2ce75f357f0
ToppCellCOVID-CD4-exh_CD4|COVID / Condition, Cell_class and T cell subcluster

TNFRSF25 SMCHD1 EZH2 TESC PNP SP140

1.18e-05197114639ee4b93625c994813044d8dd8854fba2bd99940
ToppCellsevere_COVID-19-pDC|World / disease group, cell group and cell class (v2)

PCDHGA6 AXL KANK1 PLXNA4 MMP15

5.57e-051591145e1c48c4ceda116826819ff9adeed7bad6a58844d
ToppCell343B-Myeloid-Macrophage-SPP1+_Macrophage_3|343B / Donor, Lineage, Cell class and subclass (all cells)

AXL MACROH2A1 SORCS1 CACNA1G PNP

6.09e-0516211450acb8f7b51bf422d4f4f8e99bd10360163ae4eb7
ToppCellfacs-Brain_Non-Myeloid-Cortex_-18m-Epithelial-neuronal_stem_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAM18 ITGA9 KANK1 GUCY1B2 TGDS

6.45e-0516411450853e75b60b2a78257b660910c3ee15b09c5f5b0
ToppCell3'_v3-GI_small-bowel-Lymphocytic_Invariant-Inducer-like-ILC3|GI_small-bowel / Manually curated celltypes from each tissue

TNFRSF25 MPV17L MACROH2A1 SORCS1 FES

6.83e-051661145773673a5d0430640439845b264740bfbbdad0cb2
ToppCell3'_v3-GI_small-bowel-Lymphocytic_Invariant-Inducer-like|GI_small-bowel / Manually curated celltypes from each tissue

TNFRSF25 MPV17L MACROH2A1 SORCS1 FES

7.03e-0516711453ae46c6363da76c8e1f5579e6027bf88ed637a44
ToppCell3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-mesothelial_cell|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TM9SF1 FREM2 TRPM3 PTPRQ FGF9

7.43e-0516911450cece9b2bb1f58e465c20ec8735a4fc3c1021f03
ToppCell3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-mesothelial_cell-Mesothelium|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TM9SF1 FREM2 TRPM3 PTPRQ FGF9

7.43e-0516911456937c46b119d4ce382fc8c2fa5925ede5ae89c81
ToppCellE16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Chondrocyte-Chondrocyte_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SETMAR ECM2 PAPSS2 KANK1 TGDS

8.76e-051751145a5db428b078938627e61b7e944c1e0c1d61ac2da
ToppCellE16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Chondrocyte|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SETMAR ECM2 PAPSS2 KANK1 TGDS

8.76e-0517511458b498eea1ec1c1f27b171025c3d08adf3687bafc
ToppCellPND01-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FREM2 KANK1 PTPRQ FGF9 SULT4A1

9.00e-0517611458e7f38de8bf68077e2138f4d06c1f55b0fd096cc
ToppCellPND01-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FREM2 KANK1 PTPRQ FGF9 SULT4A1

9.00e-051761145ed575330a08a6748ea4b28433292c8cfd157d444
ToppCellCOVID-19-kidney-PCT-S1/S2|COVID-19 / Disease (COVID-19 only), tissue and cell type

A1CF SLC3A1 SORCS1 FREM2 TRPM3

9.49e-05178114523a12d3d971b857d5be8e907334d1f6b49eeeb32
ToppCellP03-Mesenchymal-mesenchymal_fibroblast-tracheal_fibroblast|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

ECM2 OTOR PAPSS2 SLC6A11 KANK1

9.49e-0517811458591a40fced747ac16b3e8ebc7a22dfb3ad76da2
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L2-4_RORB_GRIK1|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SLC6A7 TRPM3 FER1L4 TESC CDH18

9.49e-051781145674ee5095b98929c29e4f6bd56029a336cc4a38c
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L2-4_RORB_GRIK1|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SLC6A7 TRPM3 FER1L4 TESC CDH18

1.00e-041801145fd8c2059fcb382ffbfe19e598e37a49e1d5637b5
ToppCellfacs-Heart-RV-3m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EDNRA FREM2 KANK1 TESC CATSPERG

1.00e-0418011450059e5acade6c895fd629767bea1c15f40b0d1b0
ToppCellfacs-Heart-RV-3m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EDNRA FREM2 KANK1 TESC CATSPERG

1.00e-041801145dfb8412e1e06fa7349e66eea2ef27d9ea98b7893
ToppCellChildren_(3_yrs)-Mesenchymal-myofibroblast_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

DPYSL3 ITGA9 EDNRA GOT1L1 PLXNA4

1.00e-04180114501f2e5d96016823482f89ba503d007d4bd88eeac
ToppCellCOVID-19-kidney-Stressed_PCT|COVID-19 / Disease (COVID-19 only), tissue and cell type

A1CF SLC3A1 SORCS1 FREM2 TRPM3

1.03e-0418111456980ea624151da32b7f537f263e40fcb87a02e81
ToppCelldroplet-Kidney-KIDNEY-1m-Epithelial-kidney_proximal_convoluted_tubule_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACO1 ACY3 PAPSS2 SLC3A1 SLC16A2

1.05e-041821145faf0dfa3adc2d2706b6942b5127093ccdc856447
ToppCellPCW_05-06-Neuronal-Neuronal_SCP-neuro_proliferating_SCP2_(1)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

OTOR SORCS1 TRPM3 PLXNA4 MMP15

1.05e-041821145f7f9be9c7ef8da9864d6aefe20043b26e1bb8697
ToppCelldroplet-Kidney-KIDNEY-1m-Epithelial-Epcam____kidney_proximal_convoluted_tubule_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACO1 ACY3 PAPSS2 SLC3A1 SLC16A2

1.05e-041821145be8dd52898525ce6632af0adc2801944f3ac10bd
ToppCellTCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-7|TCGA-Prostate / Sample_Type by Project: Shred V9

ACACA U2AF2 EZH2 MTHFD1 NAA20

1.05e-041821145af16334fec2c757b03c84cf252d00e92fa81e4cd
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PAPSS2 TAOK3 CLCN5 FGF9 TESC

1.11e-0418411458fd8bd3d28d0ee6f0ef1f14e354d8eaf63a8081b
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

ACACA ITGA9 PEBP4 FREM2 SEMA3E

1.11e-041841145102105ae1a5ef6d42a43f6d9b00f12ed0690ddb7
ToppCellwk_15-18-Epithelial-Distal_epithelial_progenitor-epi-tip_intermediate|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

ERBB2 PDPR POLE FREM2 CLCN5

1.14e-041851145636505a3d96f75d951ab42bcf8af6ae07abc732d
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-AT_1|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ERBB2 ITGA9 TRPM3 PTPRQ SEMA3E

1.14e-041851145c82eab551f65ecebe6db908eda9f9eb3414693c7
ToppCell343B-Fibroblasts-Fibroblast-E-|343B / Donor, Lineage, Cell class and subclass (all cells)

ITGA11 DPYSL3 ECM2 ITGA9 FGF9

1.17e-0418611451bac7825c2fe3e6cdff65026b09b9ccaa40fa27f
ToppCellCOVID_vent-Myeloid-Dendritic|COVID_vent / Disease condition, Lineage, Cell class and subclass

AXL MACROH2A1 PAPSS2 CLCN5 FES

1.17e-04186114563a5cdd3f60681762a218be32db84be8f29b88fd
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ERBB2 ITGA9 TRPM3 PTPRQ SEMA3E

1.17e-0418611453aebe163799109ffc67e4e10ee47c2dd0886a92c
ToppCell343B-Fibroblasts-Fibroblast-E|343B / Donor, Lineage, Cell class and subclass (all cells)

ITGA11 DPYSL3 ECM2 ITGA9 FGF9

1.17e-04186114559db239f1864a5d4f1570c93219dbd7ac5b6db35
ToppCellCOVID_vent-Myeloid-Dendritic-cDC|COVID_vent / Disease condition, Lineage, Cell class and subclass

AXL MACROH2A1 PAPSS2 CLCN5 FES

1.17e-04186114539457a7b43537f2c3e221f9375c95d4515424d7d
ToppCellpdx-Tumor_cells-T5|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

ITGA9 SORCS1 FREM2 CLCN5 FGF9

1.20e-0418711457e376831a11ee72ed87abcdac631ca46ae29c250
ToppCelldroplet-Kidney-nan-18m-Epithelial-Pecam____Kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ECM2 PCDHB10 ITGA9 PLXNA4 FGD5

1.20e-041871145e93cad16a087d1443cbf4e1690dc1b35d7a84c41
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PAPSS2 TAOK3 CLCN5 FGF9 TESC

1.23e-0418811452ee64bc73a2251fd9f374be759b442cf4ed0d19e
ToppCellCOVID-19-kidney-T-cells-2|COVID-19 / Disease (COVID-19 only), tissue and cell type

CYLD EZH2 GFM2 PIP4K2A SP140

1.23e-04188114515484c05cb496cd98ed3f79a6134c5cec8f09a4d
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PAPSS2 EDNRA SORCS1 PLXNA4 CDH18

1.29e-0419011451bbbf0ce222e51f9fd2daca0c18d3965fd4efd31
ToppCell10x_3'_v2v3-Neoplastic-Stem-like-NPC-like-NPC-like_neural-D|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

DPYSL3 PCDHB10 FAXC PLXNA4 FGF9

1.29e-041901145b4dfc41f5a630140cab8b1b86de85de0f5b25e4a
ToppCellILEUM-non-inflamed-(6)_ILC3|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

TNFRSF25 MPV17L MACROH2A1 SORCS1 FES

1.32e-0419111456eaf72b41084404bee0db04e4605db745a74995f
ToppCelldroplet-Kidney-KIDNEY-1m-Epithelial-Pecam____Kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ECM2 PCDHB10 ITGA9 EDNRA FGD5

1.32e-041911145b9ae5af426e7a1f2652a47700bb168371bd2dec6
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Degenerative_Outer_Medullary_Collecting_Duct_Principal_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PAPSS2 TRPM3 MMP15 AGRN PNP

1.35e-041921145967122c53af25b8f19a8411b4553d764c8d51c4d
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb-3m-Mesenchymal-mesenchymal_stem_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGA11 DPYSL3 AXL ECM2 FKBP9

1.35e-041921145beac6b3c191b11add8e39e8d04562b478ea8929e
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2-D122|Adult / Lineage, Cell type, age group and donor

ACACA USP9Y PEBP4 FREM2 KANK1

1.35e-04192114506013a07e3a873b1d1c0451643c528593ac32a9c
ToppCelldroplet-Limb_Muscle-nan-3m-Mesenchymal-mesenchymal_stem_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGA11 DPYSL3 AXL ECM2 FKBP9

1.39e-041931145428b1a3ad87dff7f65de5161d40f102572a9341b
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DNAH7 SLC3A1 KANK1 CLCN5 TRPM3

1.39e-04193114582e8a4c40299ffcdfd5a0da711bb9de6fb8a2eaa
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DNAH7 KANK1 CLCN5 TRPM3 DIP2C

1.39e-0419311453866667dd221612589ae50f5c52f73a183a49ce6
ToppCellfacs-Diaphragm-Limb_Muscle-3m-Mesenchymal-mesenchymal_stem_cell|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGA11 DPYSL3 AXL ECM2 FKBP9

1.39e-041931145160691b671710be10220803d788c2c961c236af1
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DNAH7 SLC3A1 FREM2 KANK1 CLCN5

1.42e-0419411455eaaa81f4b2535f983c424aaef00077089526a5c
ToppCellRA|World / Chamber and Cluster_Paper

DPYSL3 AXL EDNRA SORCS1 PTPRQ

1.42e-04194114508f0afbb68a63150fbe107a5337299081c3f69e4
ToppCelldroplet-Limb_Muscle-nan-21m-Mesenchymal-chondrocyte-like|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DPYSL3 AXL ECM2 FKBP9 PNP

1.45e-041951145d2c9c58b46bf96f9a536e177b995e340b55c6750
ToppCellILEUM-inflamed-(6)_ILC3|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

TNFRSF25 MPV17L MACROH2A1 SORCS1 FES

1.45e-041951145c6968da7d2b60c2163e1ff0ffa41340e1ec1d2ed
ToppCellMild-CD4+_T_activated|Mild / Disease group and Cell class

CYLD TNFRSF25 SMCHD1 HNRNPLL SP140

1.49e-041961145daa1c3322d81e649161e889e1d78451d2d425d09
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DNAH7 SLC3A1 FREM2 KANK1 CLCN5

1.49e-0419611456ce74aa3f0ce3ca284b67e5a4660ffd2cc9611e0
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Layer_VI_Pan-area|World / Primary Cells by Cluster

SORCS1 TRPM3 CDC42 CDH18 SEMA3E

1.53e-04197114579b9e7f2e8e33b3c547f716be5667156c48b0dfc
ToppCellParenchymal-NucSeq-Epithelial-Epi_alveolar-AT1|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PAPSS2 PAPSS1 PTPRQ AGRN SEMA3E

1.53e-0419711458d5097898dd01cedb04cb694cb480c931e08462c
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Layer_VI_Pan-area-33|World / Primary Cells by Cluster

SORCS1 TRPM3 CDC42 CDH18 SEMA3E

1.53e-041971145d20f29088e9afd8a960d6f680075c380e550f8a7
ToppCell(3)_Chondrocytes-(34)_Chondro-progen|(3)_Chondrocytes / Cell class and subclass of bone marrow stroma cells in homeostatis

DPYSL3 AXL ECM2 TESC SEMA3E

1.53e-041971145012c49a57f9c2a3dfa988cd3882c8c6b7ef3a5ad
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Pericyte-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ITGA11 TM9SF1 EDNRA TESC AGRN

1.53e-0419711452872a78b1be61aa1d50bc9a49294a21e922dc033
ToppCellControl_saline-Epithelial_alveolar-AT_1-Differentiating_AT1|Control_saline / Treatment groups by lineage, cell group, cell type

ERBB2 PAPSS2 TRPM3 PTPRQ SEMA3E

1.56e-04198114585f424cd9bb3117c9e322031024aabb87696ce47
ToppCellfacs-Trachea-nan-3m-Mesenchymal-fibroblast|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DPYSL3 AXL ECM2 FKBP9 EDNRA

1.56e-0419811450dc7d59a07428a7b7e8bdc81f0e2417dd4ce3cf2
ToppCellSepsis-Leuk-UTI-Lymphocyte-T/NK-Treg|Leuk-UTI / Disease, condition lineage and cell class

ITGA9 SLC3A1 PCSK7 HNRNPLL SEMA3E

1.60e-041991145100f45e04f284551b29ef0406476bdc347ddbf7e
ToppCellmLN-ILC-ILC|mLN / Region, Cell class and subclass

TNFRSF25 MPV17L MACROH2A1 SORCS1 FES

1.60e-041991145ab09a06cdea2597e9fe4b4b304655e9de4d433f6
ToppCellmLN-ILC|mLN / Region, Cell class and subclass

TNFRSF25 MPV17L MACROH2A1 SORCS1 FES

1.60e-041991145d6c299312c747fb1b7c53644c53efc03a5fffe85
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Parietal_and_Temporal-6|World / Primary Cells by Cluster

SORCS1 TRPM3 PLXNA4 CDC42 SEMA3E

1.60e-0419911451b1bccf4293f11048709d15a3c892c0edf3da3d2
ToppCellmLN-(3)_ILC|mLN / shred on region, Cell_type, and subtype

TNFRSF25 MPV17L MACROH2A1 SORCS1 FES

1.60e-04199114500e0e2a766dd9c4d0a65f53d88fa50df4b6a3d60
ToppCell(2)_Fibroblasts|World / Cell class and subclass of bone marrow stroma cells in homeostatis

DPYSL3 AXL ECM2 FGF9 SEMA3E

1.60e-041991145777423b413376b0d3fbd92ff51dd0133fb54d293
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Parietal_and_Temporal|World / Primary Cells by Cluster

SORCS1 TRPM3 PLXNA4 CDC42 SEMA3E

1.60e-0419911454bee94c116c0da5eba951cb4cea7cc9dcdd6e30f
ToppCellmLN-(3)_ILC-(30)_ILC|mLN / shred on region, Cell_type, and subtype

TNFRSF25 MPV17L MACROH2A1 SORCS1 FES

1.60e-04199114533ac6d77099076df01299be429f4ba96f2f34cc1
ToppCell(2)_Fibroblasts-(24)_Fibro-5|World / Cell class and subclass of bone marrow stroma cells in homeostatis

DPYSL3 AXL ECM2 FGF9 SEMA3E

1.60e-0419911456c0354f57883330c685a8d9d5d3014ace7eca584
ToppCellTransverse-(3)_ILC-(30)_ILC|Transverse / shred on region, Cell_type, and subtype

TNFRSF25 MPV17L MACROH2A1 SORCS1 FES

1.64e-042001145528520dc98775aca6cc7568fedf5906ea55e0bea
ToppCellTransverse-(3)_ILC|Transverse / shred on region, Cell_type, and subtype

TNFRSF25 MPV17L MACROH2A1 SORCS1 FES

1.64e-042001145c1ad7cb012e1c8911e417f7d64ca662c4f5010e0
ToppCellmLN-Macrophage-LYVE1_Macrophage|Macrophage / Region, Cell class and subclass

SPTLC2 SMCHD1 PAPSS2 PAPSS1 FES

1.64e-042001145e3c15e0e1c2602b0cc9ab8cc50c978d265350c94
ToppCellLPS_IL1RA_TNF-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

ERBB2 ITGA9 TRPM3 PTPRQ SEMA3E

1.64e-042001145ddfb1f006365bf16203ee49f20200f68220cc288
ToppCellTransverse-ILC|Transverse / Region, Cell class and subclass

TNFRSF25 MPV17L MACROH2A1 SORCS1 FES

1.64e-042001145eb04d6ad2270d3d9ac3d1fae1bb9bedc6fca38fe
ToppCellTransverse-ILC-ILC|Transverse / Region, Cell class and subclass

TNFRSF25 MPV17L MACROH2A1 SORCS1 FES

1.64e-04200114560ec185df2f1989bf8febf75b11c46a576829be3
ToppCellSigmoid-ILC|Sigmoid / Region, Cell class and subclass

TNFRSF25 MPV17L MACROH2A1 SORCS1 FES

1.64e-042001145dfb06821f1019833f5d81f9c93808219b5fef407
ToppCellILEUM-inflamed-(1)_T_cell-(1)_Highly_activated_T_cells|(1)_T_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

PSMB2 MACROH2A1 SSRP1 EZH2 TESC

1.64e-042001145d92d3bc63a56a604d7b1d49e62d4304e5e4017f2
ToppCellSigmoid-(3)_ILC|Sigmoid / shred on region, Cell_type, and subtype

TNFRSF25 MPV17L MACROH2A1 SORCS1 FES

1.64e-042001145a7326c43987a5eb4f4f5b48c4252cf4870432e5d
ToppCellSigmoid-(3)_ILC-(30)_ILC|Sigmoid / shred on region, Cell_type, and subtype

TNFRSF25 MPV17L MACROH2A1 SORCS1 FES

1.64e-042001145c39de94623383da7b2b260eb016ddaa5da7f4350
ToppCellILEUM-inflamed-(1)_Highly_activated_T_cells|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

PSMB2 MACROH2A1 SSRP1 EZH2 TESC

1.64e-0420011456ff811fdfe49b5b0aea0e88fae80bfaaf40eb7c4
ToppCell(3)_ILC|World / shred on Cell_type and subtype

TNFRSF25 MPV17L MACROH2A1 SORCS1 FES

1.64e-04200114503554b3f323785b1e0b48fa32de0d92065dd798e
ToppCellSigmoid-ILC-ILC|Sigmoid / Region, Cell class and subclass

TNFRSF25 MPV17L MACROH2A1 SORCS1 FES

1.64e-0420011454ac1e6d7f358003e2448eb69e545772cd261c55f
ToppCell(5)_Fibroblast-B_(Myofibroblast)|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

ITGA11 CEL ECM2 FKBP9 EDNRA

1.64e-0420011459bbaa666d0f3b4782c1b4b95e0fa5fc1467842d8
ToppCell(30)_ILC|World / shred on Cell_type and subtype

TNFRSF25 MPV17L MACROH2A1 SORCS1 FES

1.79e-042041145bd9fbd278c05e396463704d711b60d47699e3c09
DrugMethylmercury Compounds

ACACA MACROH2A1 DNAH7 ARAF SLC3A1 FREM2 PPP2R1B LONP1 NAA20 NIP7 CACNA1G CDC42 HNRNPLL AGRN SDHA PNP HDLBP

7.82e-0785111117ctd:D008767
Drugmanganese

ERBB2 ITGA11 SETMAR CAD ACO1 MACROH2A1 ITGA9 ARAF PPP2R1B GUCY1B2 FES PKN1 CACNA1G ENDOG AGRN PNP

1.45e-0679111116CID000023930
Drugvinylidene chloride

DPYSL3 AXL ACO1 MPV17L POLE ACY3 EZH2 PAPSS2 PAPSS1 SLC3A1 FREM2 H2AC20 TAOK3 KANK1 SH3GLB1 SLC16A2 MTHFD1 FGF9 FGD5 SDHA SEMA3E

7.97e-06147511121ctd:C029297
Diseasecancer (implicated_via_orthology)

POLE RANBP6 SSRP1 ARAF KANK1 PIP4K2A PIP4K2B

6.02e-052681087DOID:162 (implicated_via_orthology)
DiseaseAdenocarcinoma of large intestine

ERBB2 POLE ARAF PKN1

4.35e-04961084C1319315
DiseaseHead and Neck Carcinoma

CYLD ERBB2

5.86e-04101082C3887461
DiseaseHYPOGONADOTROPIC HYPOGONADISM 7 WITH OR WITHOUT ANOSMIA

AXL SEMA3E

7.14e-04111082146110
DiseaseHypogonadotropic hypogonadism 7 with or without anosmia

AXL SEMA3E

7.14e-04111082cv:C0342384
DiseaseCOVID-19, coronary artery disease

AXL EDNRA

1.01e-03131082EFO_0001645, MONDO_0100096
Diseaseillegal drug consumption

FAXC ITGA9

1.01e-03131082EFO_0005431
DiseaseSmall cell carcinoma of lung

TAOK3 FER DIP2C

1.03e-03541083C0149925
Diseaseloneliness measurement

DPYSL3 OTOR SLC6A11 TAOK3

1.14e-031241084EFO_0007865
DiseaseNeoplasm of lung

ERBB2 PPP2R1B

1.17e-03141082cv:C0024121
DiseaseLung cancer

ERBB2 PPP2R1B

1.17e-03141082cv:C0242379
DiseaseLUNG CANCER

ERBB2 PPP2R1B

1.17e-03141082211980
DiseaseBenign neoplasm of stomach

ERBB2 POLE

1.74e-03171082C0153943
DiseaseNeoplasm of uncertain or unknown behavior of stomach

ERBB2 POLE

1.74e-03171082C0496905
DiseaseCarcinoma in situ of stomach

ERBB2 POLE

1.74e-03171082C0154060
DiseaseMalignant neoplasm of breast

ERBB2 ITGA9 EZH2 ARAF EDNRA SORCS1 NIP7 DIP2C FGD5 PADI3 HDLBP

1.95e-03107410811C0006142
DiseaseChild Behaviour Checklist assessment

PEBP4 KANK1

1.95e-03181082EFO_0005661
DiseaseIdiopathic hypogonadotropic hypogonadism

AXL SEMA3E

1.95e-03181082C0342384
Diseasemitochondrial heteroplasmy measurement

SLC6A7 LONP1 PNP

2.10e-03691083EFO_0600008
Diseasecardiomyopathy (implicated_via_orthology)

ERBB2 ARAF SDHA

2.27e-03711083DOID:0050700 (implicated_via_orthology)
Diseasestomach cancer (is_implicated_in)

ERBB2 BCOR EZH2

2.37e-03721083DOID:10534 (is_implicated_in)
Diseasetemporal horn of lateral ventricle volume measurement

ACO1 DIP2C SEMA3E

2.37e-03721083EFO_0010333
DiseaseNon-Small Cell Lung Carcinoma

CYLD ERBB2 AXL FGF9

2.63e-031561084C0007131
DiseaseStomach Carcinoma

ERBB2 POLE

2.66e-03211082C0699791
DiseaseNephritis, Tubulointerstitial

SLC3A1 CLCN5

2.66e-03211082C0041349
DiseaseCleft Palate

EDNRA TGDS FGF9

3.31e-03811083C0008925
DiseaseNephritis, Interstitial

SLC3A1 CLCN5

3.48e-03241082C0027707
Diseasebody fat percentage, coronary artery disease

HORMAD1 FES

3.48e-03241082EFO_0001645, EFO_0007800

Protein segments in the cluster

PeptideGeneStartEntry
GVMPYLSQLGFDVVG

ACO1

486

P21399
IEYMPLLAGQLGVEF

PPP2R1B

436

P30154
GEELFNLMPQYFVGV

CATSPERG

221

Q6ZRH7
EILDEAYVMAGVGSP

ERBB2

766

P04626
MDQPAGLQVDYVFRG

CCDC61

1

Q9Y6R9
PAFEMEAYRPVGVVD

ACY3

216

Q96HD9
VFEVPNGYSVLGMER

ANKRD13D

461

Q6ZTN6
EIYMNVPVGAAGVRG

A1CF

381

Q9NQ94
FGIYDEGVGMLVVVA

GOT1L1

251

Q8NHS2
IAMYPDAIGLEGFSV

ADAM18

301

Q9Y3Q7
YNIFEGMELRGAPLV

DPYSL3

431

Q14195
AERVGAGAPVYMAAV

H2AC20

41

Q16777
IGVGAPVYMAAVLEY

MACROH2A1

41

O75367
MAPLGEVGNYFGVQD

FGF9

1

P31371
EGVEGQELFYTPEMA

AGRN

1141

O00468
DGLQAAEEVGYPVMI

ACACA

296

Q13085
AIGFVMVPFEYRGEQ

EDNRA

221

P25101
MLHYVGFVPVIDGDF

CEL

301

P19835
PEFVTYQDALGLGMV

BCOR

711

Q6W2J9
FELVGPMQASQAIGY

SLC16A2

436

P36021
QDEMGVVGYFPRNLV

OTOR

91

Q9NRC9
IEEMYQLYGGPVVLV

PLA2G15

181

Q8NCC3
ANLVEFGAKEPYMEG

RASA1

941

P20936
GYPLMLFLEEGGVVT

RAD1

116

O60671
IPGTALVEMGDEYAV

HNRNPLL

371

Q8WVV9
DIIAFPLQDYGGIMA

FAXC

41

Q5TGI0
MIAGANFYIVGRDPA

PAPSS2

501

O95340
EVYDPDVGMNSLQGF

PCDHGA6

156

Q9Y5G7
MQRFYGIPVTGVLDE

MMP15

86

P51511
GDIIYGRVMVDPVQN

FREM2

2891

Q5SZK8
MDLGIILDQPDGQFY

FER1L4

111

A9Z1Z3
IPYMGDEVLDQDGTF

EZH2

131

Q15910
EYFIVAEAPGGELMG

NAA20

41

P61599
IGAVDEEGRMPFYAE

PCSK7

351

Q16549
DGYIPAEQIVCEMGE

PLXNA4

906

Q9HCM2
ESPAVQGYFVLAGMN

PDPR

371

Q8NCN5
QEYGINPERTVMVGD

PGP

246

A6NDG6
FPGAVDGATYILVMV

PEBP4

81

Q96S96
FAEAYELEGPMVPNI

DNAH8

1211

Q96JB1
ALDDALANPYVMGVG

FGD5

421

Q6ZNL6
AIPAMVGDYIAAFEA

KANK1

1131

Q14678
GQRVVDNPIYLSDMG

LONP1

321

P36776
IPDFVYGQKDLMAEG

GDPGP1

26

Q6ZNW5
VFDNYAVTVMIGGEP

CDC42

36

P60953
VGALPGMITFSQDYV

POLE

2041

Q07864
GDGVTDVLLVGAPMY

ITGA11

491

Q9UKX5
DVLLVGAPMYFNEGR

ITGA11

496

Q9UKX5
NISGGDEGMIYPELV

PCDHB10

181

Q9UN67
GTEMFEVYGTPGVDI

PADI3

36

Q9ULW8
YEMYHPIGGDVALVQ

PRSS38

141

A1L453
GYLEQPGGEAMIEYI

MROH1

421

Q8NDA8
AERVGAGAPVYMAAV

H2AC18

41

Q6FI13
IGCPVNMVEVDFFGF

OOSP4A

56

A0A2R8YFL7
VNIVEPMVGLYEGSA

PTPRQ

506

Q9UMZ3
DTYIGQGYVIPGMDE

FKBP9

306

O95302
PGEIGLNYVLMADVA

ITGA9

506

Q13797
MVAGANFYIVGRDPA

PAPSS1

511

O43252
DQIIFMVGRGYLSPD

ARAF

516

P10398
IMYDGLDAVGVDQQP

CACNA1G

1491

O43497
QPVYIIMELVSGGDF

FER

631

P16591
FELTGGLEYIVPLMA

CLCN5

596

P51795
VFVDDVNMPAREVYG

DNAH7

2041

Q8WXX0
YGNAELMETGDGVPV

DIP2C

236

Q9Y2E4
NQIERIPGYVFGHME

ECM2

566

O94769
QDVYYLPIMISDGGI

CDH18

561

Q13634
VIFEGEPMYLNVGEV

HORMAD1

201

Q86X24
LGYFVGVDMDNPIGN

CYLD

261

Q9NQC7
ELQEGTYVMVAGPSF

PNP

186

P00491
GGGYSQVIPMEEFNL

MTHFD1

426

P11586
PQFLGMYRLNVDGVE

PIP4K2A

176

P48426
PIYIVMELVQGGDFL

FES

631

P07332
VYIVPGSQEEDPVGM

SMG8

336

Q8ND04
VVIGFVPLAEIMGYS

GFM2

726

Q969S9
VYATGGEVQIAMEPQ

SMCHD1

641

A6NHR9
MVLQENGYGVEEDIP

SLC9B1P1

1

A6NJY1
NGYGVEEDIPTLLMA

SLC9B1P1

6

A6NJY1
APAAVVELENYGMPF

SDHA

146

P31040
VVVYSMADIPLGFGV

NIP7

131

Q9Y221
EAAGGQIELRTYVMP

ENDOG

236

Q14249
DIVMYFAVALLGGGP

OR7A10

196

O76100
YEEPMDVVALFGLRG

POMGNT1

341

Q8WZA1
PQFLGMYRLTVDGVE

PIP4K2B

181

P78356
ETIGDAYMVVGGVPV

GUCY1B2

436

O75343
MEYLIGIQGPDYVLV

PSMB2

1

P49721
METFVDPTYIGNIGR

SETMAR

206

Q53H47
LLGQYMIDAGTEFGP

SH3GLB1

96

Q9Y371
PITYYGEEIGMGNIV

SLC3A1

476

Q07837
APEVILAMDEGQYDG

TAOK3

186

Q9H2K8
LGVLLYEMLVGESPF

PKN1

801

Q16512
NPEVRQAAAYGLGVM

RANBP6

926

O60518
GYMSQELGVPVDQVA

SLC6A7

346

Q99884
MEVRFYVPPTQEDGV

SSRP1

161

Q08945
GQMEPDQVYEGITFE

TESC

171

Q96BS2
RPDVGYVQGMSFIAA

TBC1D14

501

Q9P2M4
PGEIYNIGTNFEMSV

TGDS

251

O95455
INNEVLMDGSGPAFY

TEX13D

21

A0A0J9YY54
VVGAPIAVSAFYVGM

MPV17L

91

Q2QL34
YLVSQGADPDEIGLM

SULT4A1

66

Q9BR01
MADVAVYGVEVPGTE

SLC27A4

531

Q6P1M0
MGFIIYGNEDSPVVP

SPTLC2

456

O15270
MIYGEVFADQIDPPC

TRPM3

1076

Q9HCF6
IANDLMYIADLGPGI

WASH2P

256

Q6VEQ5
YQGQDTPEVLMDIGL

AXL

371

P30530
LGFMAYEQGVPIAEV

SLC6A11

356

P48066
MGPYTVAGVANLERD

USP9Y

1826

O00507
QPAGLGAVYAALERM

TNFRSF25

386

Q93038
EVVFQTGMVGYPEAL

CAD

26

P27708
LYVGNIPFGITEEAM

U2AF2

151

P26368
VPGMNGIDTYFDELE

SEMA3E

296

O15041
HGYPQVEGFVQDMRL

SP140

811

Q13342
FIAGPYNRLVGEIMQ

HDLBP

236

Q00341
IGDYNMDGYPDALVI

ITFG1

336

Q8TB96
PEGNIMIDLYEVAGI

SORCS1

461

Q8WY21
FVVDDLPIRGFVGYM

TM9SF1

131

O15321
MAALGDEVLDGYVFP

ZAR1

1

Q86SH2
YMDIQFDFQGIPVGG

MYO1H

166

Q8N1T3