Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	tight junction	EPPK1 ANK3 SIPA1L3 SAPCD2 PARD6A CTNND1 CDK4	1.41e-05	139	118	7	GO:0070160
GeneOntologyCellularComponent	bicellular tight junction	EPPK1 ANK3 SAPCD2 PARD6A CTNND1 CDK4	1.00e-04	131	118	6	GO:0005923
GeneOntologyCellularComponent	mitotic spindle	KAT2A DCTN1 NEDD9 SLC34A1 CKAP2L WDR62 KIF22	1.47e-04	201	118	7	GO:0072686
GeneOntologyCellularComponent	apical junction complex	EPPK1 ANK3 SAPCD2 PARD6A CTNND1 CDK4	2.78e-04	158	118	6	GO:0043296
GeneOntologyCellularComponent	spindle	DIDO1 KAT2A DCTN1 NEDD9 SLC34A1 CTDP1 CKAP2L UHRF1 WDR62 KIF22	3.41e-04	471	118	10	GO:0005819
GeneOntologyCellularComponent	mRNA cleavage and polyadenylation specificity factor complex	WDR33 CSTF2 CSTF2T	4.15e-04	26	118	3	GO:0005847
GeneOntologyCellularComponent	cell-cell junction	EPPK1 ANK3 SIPA1L3 ITGA5 SAPCD2 PTK2 PARD6A PVR CTNND1 CDH8 CDK4	5.24e-04	591	118	11	GO:0005911
GeneOntologyCellularComponent	cell leading edge	ATP6V1B2 ADGRV1 ITGA5 DCTN1 PTK2 NEDD9 RAB34 PARD6A ANTXR1 CTNND1	5.44e-04	500	118	10	GO:0031252
GeneOntologyCellularComponent	mRNA cleavage factor complex	WDR33 CSTF2 CSTF2T	7.02e-04	31	118	3	GO:0005849
GeneOntologyCellularComponent	eukaryotic translation initiation factor 3 complex, eIF3m	EIF3CL EIF3C	1.11e-03	9	118	2	GO:0071541
GeneOntologyCellularComponent	cell cortex	MYRIP DCTN1 SAPCD2 PTK2 NEDD9 PARD6A AKAP13 CTNND1	1.23e-03	371	118	8	GO:0005938
MousePheno	abnormal germ layer development	MBTPS1 PPRC1 PDPK1 KAT2A PTK2 CSTF2 UHRF1 TAL1	9.41e-06	144	101	8	MP:0001674
Domain	Calx_beta	ADGRV1 FREM3 FREM1 FREM2	1.62e-07	9	114	4	IPR003644
Domain	Calx-beta	ADGRV1 FREM3 FREM1 FREM2	1.62e-07	9	114	4	PF03160
Domain	Calx_beta	ADGRV1 FREM3 FREM2	1.21e-05	8	114	3	SM00237
Domain	Nucleotide-bd_a/b_plait	PPRC1 ESRP1 PABPN1L MSI2 SRRT DAZAP1 SYNJ1 CSTF2 CSTF2T	2.92e-05	258	114	9	IPR012677
Domain	CSTF2_hinge	CSTF2 CSTF2T	3.69e-05	2	114	2	IPR025742
Domain	CSTF2_hinge	CSTF2 CSTF2T	3.69e-05	2	114	2	PF14327
Domain	CSTF_C	CSTF2 CSTF2T	3.69e-05	2	114	2	PF14304
Domain	EIF3C_N_dom	EIF3CL EIF3C	3.69e-05	2	114	2	IPR008905
Domain	eIF-3c_N	EIF3CL EIF3C	3.69e-05	2	114	2	PF05470
Domain	EIF3C	EIF3CL EIF3C	3.69e-05	2	114	2	IPR027516
Domain	CSTF_C	CSTF2 CSTF2T	3.69e-05	2	114	2	IPR026896
Domain	RRM_dom	PPRC1 ESRP1 PABPN1L MSI2 DAZAP1 SYNJ1 CSTF2 CSTF2T	7.67e-05	227	114	8	IPR000504
Domain	RRM	PPRC1 ESRP1 PABPN1L MSI2 DAZAP1 SYNJ1 CSTF2 CSTF2T	8.40e-05	230	114	8	PS50102
Domain	Cadherin	PCDHGA4 FREM3 FREM1 FREM2 CELSR2 CDH8	8.57e-05	118	114	6	IPR002126
Domain	AT_hook	PATZ1 CECR2 BAZ2A	1.17e-04	16	114	3	PF02178
Domain	-	PPRC1 ESRP1 PABPN1L MSI2 DAZAP1 SYNJ1 CSTF2 CSTF2T	1.27e-04	244	114	8	3.30.70.330
Domain	RRM_1	PPRC1 ESRP1 PABPN1L MSI2 DAZAP1 CSTF2 CSTF2T	2.89e-04	208	114	7	PF00076
Domain	ATP_synth_asu_C	ATP6V1B2 ATP5F1A	3.65e-04	5	114	2	IPR000793
Domain	ATPase_a/bsu_AS	ATP6V1B2 ATP5F1A	3.65e-04	5	114	2	IPR020003
Domain	ATP-synt_ab_N	ATP6V1B2 ATP5F1A	3.65e-04	5	114	2	PF02874
Domain	ATP-synt_ab_C	ATP6V1B2 ATP5F1A	3.65e-04	5	114	2	PF00306
Domain	ATPase_F1/V1/A1_a/bsu_N	ATP6V1B2 ATP5F1A	3.65e-04	5	114	2	IPR004100
Domain	ATP-synt_ab	ATP6V1B2 ATP5F1A	3.65e-04	5	114	2	PF00006
Domain	ATPASE_ALPHA_BETA	ATP6V1B2 ATP5F1A	3.65e-04	5	114	2	PS00152
Domain	RRM	PPRC1 ESRP1 PABPN1L MSI2 DAZAP1 CSTF2 CSTF2T	3.73e-04	217	114	7	SM00360
Domain	Bromodomain_CS	CECR2 KAT2A BAZ2A	5.20e-04	26	114	3	IPR018359
Domain	ATPase_F1/V1/A1_a/bsu_nucl-bd	ATP6V1B2 ATP5F1A	5.45e-04	6	114	2	IPR000194
Domain	AT_hook	PATZ1 AHDC1 BAZ2A	5.82e-04	27	114	3	SM00384
Domain	AT_hook_DNA-bd_motif	PATZ1 AHDC1 BAZ2A	5.82e-04	27	114	3	IPR017956
Domain	HMGI/Y_DNA-bd_CS	PATZ1 CECR2 BAZ2A	8.79e-04	31	114	3	IPR000637
Domain	PHD	MTF2 DIDO1 BAZ2A UHRF1	1.15e-03	75	114	4	PF00628
Domain	Znf_PHD-finger	MTF2 DIDO1 BAZ2A UHRF1	1.39e-03	79	114	4	IPR019787
Domain	BROMODOMAIN_1	CECR2 KAT2A BAZ2A	1.48e-03	37	114	3	PS00633
Domain	Bromodomain	CECR2 KAT2A BAZ2A	1.60e-03	38	114	3	PF00439
Domain	ZU5	ANK3 PIDD1	1.61e-03	10	114	2	PS51145
Domain	BROMODOMAIN_2	CECR2 KAT2A BAZ2A	1.99e-03	41	114	3	PS50014
Domain	Znf_FYVE_PHD	MTF2 MYRIP DIDO1 BAZ2A UHRF1	2.08e-03	147	114	5	IPR011011
Domain	BROMO	CECR2 KAT2A BAZ2A	2.14e-03	42	114	3	SM00297
Domain	Bromodomain	CECR2 KAT2A BAZ2A	2.14e-03	42	114	3	IPR001487
Domain	-	CECR2 KAT2A BAZ2A	2.14e-03	42	114	3	1.20.920.10
Domain	PHD	MTF2 DIDO1 BAZ2A UHRF1	2.16e-03	89	114	4	SM00249
Domain	Znf_PHD	MTF2 DIDO1 BAZ2A UHRF1	2.34e-03	91	114	4	IPR001965
Domain	ZU5	ANK3 PIDD1	2.34e-03	12	114	2	PF00791
Domain	ZU5_dom	ANK3 PIDD1	2.34e-03	12	114	2	IPR000906
Domain	ZF_PHD_2	MTF2 DIDO1 BAZ2A UHRF1	2.74e-03	95	114	4	PS50016
Domain	ZF_PHD_1	MTF2 DIDO1 BAZ2A UHRF1	2.84e-03	96	114	4	PS01359
Domain	-	ANK3 NFKBIZ ANKRD63 SHANK3 NFKBIE AKAP13	4.17e-03	248	114	6	1.25.40.20
Domain	PINT	EIF3CL EIF3C	4.19e-03	16	114	2	SM00088
Domain	Ankyrin_rpt-contain_dom	ANK3 NFKBIZ ANKRD63 SHANK3 NFKBIE AKAP13	4.69e-03	254	114	6	IPR020683
Domain	PCI_dom	EIF3CL EIF3C	4.73e-03	17	114	2	IPR000717
Domain	PCI	EIF3CL EIF3C	4.73e-03	17	114	2	PF01399
Domain	CA	PCDHGA4 FREM2 CELSR2 CDH8	5.41e-03	115	114	4	SM00112
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	CRYBG2 EPPK1 HIVEP2 ZNF48 PPRC1 SIPA1L3 KAT2A ITGA5 KDM6B BCL9 DCTN1 AHDC1 GAS2L1 SLC12A4 CELSR2 SYNJ1 TRAPPC12 CTDP1 AKAP13 HMGXB3 ULK1	2.06e-10	1105	120	21	35748872
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	DIP2B MBTPS1 HIVEP2 ANK3 SIPA1L3 MYRIP FAM117B MEIS3 ADGRV1 ZNF385A RBBP8NL ADCY1 AHDC1 PTK2 MSI2 KIAA1671 DAZAP1 PVR ANTXR1 IGSF9 AKAP13 CTNND1	7.61e-09	1489	120	22	28611215
Pubmed	Differential localization profile of Fras1/Frem proteins in epithelial basement membranes of newborn and adult mice.	FREM3 FREM1 FREM2	1.60e-07	4	120	3	18563433
Pubmed	Identification of a novel cell-adhesive protein spatiotemporally expressed in the basement membrane of mouse developing hair follicle.	ITGA5 FREM3 FREM1 FREM2	2.38e-07	16	120	4	15878328
Pubmed	Spatiotemporal distribution of Fras1/Frem proteins during mouse embryonic development.	FREM3 FREM1 FREM2	3.99e-07	5	120	3	17251066
Pubmed	Basement membrane localization of Frem3 is independent of the Fras1/Frem1/Frem2 protein complex within the sublamina densa.	FREM3 FREM1 FREM2	3.99e-07	5	120	3	17596926
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	ANK3 WDR33 DIDO1 POGZ DCTN1 KIAA1671 SYNJ1 BAZ2A NFKBIE CSTF2 CTNND1 CSTF2T	4.78e-07	549	120	12	38280479
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	DIP2B PDPK1 DIDO1 CHD7 POGZ BCL9 EIF3CL SRRT BAZ2A CTDP1 EIF3C SF3B2 CSTF2T WDR62	4.94e-07	774	120	14	15302935
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	ZNF48 MTF2 WDR33 PATZ1 TRMT112 DHX38 DIDO1 CHD7 POGZ KAT2A AHDC1 SRRT BAZ2A CSTF2 UHRF1 SF3B2 ATP5F1A KIF22	4.97e-07	1294	120	18	30804502
Pubmed	Frem3, a member of the 12 CSPG repeats-containing extracellular matrix protein family, is a basement membrane protein with tissue distribution patterns distinct from those of Fras1, Frem2, and QBRICK/Frem1.	FREM3 FREM1 FREM2	7.95e-07	6	120	3	17462874
Pubmed	A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway.	MBTPS1 PDPK1 SAPCD2 KIAA1671 FREM2 ANTXR1 EIF3C ATP5F1A CDK4	1.12e-06	302	120	9	30561431
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	WDR33 DHX38 ESRP1 DIDO1 POGZ SRRT BAZ2A EIF3C SF3B2	3.03e-06	341	120	9	32971831
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	ZNF48 MTF2 PATZ1 DIDO1 NFKBIZ POGZ KAT2A ZNF385A BAZ2A UHRF1 HMGXB3 OLIG1 SF3B2	4.66e-06	808	120	13	20412781
Pubmed	The extracellular matrix gene Frem1 is essential for the normal adhesion of the embryonic epidermis.	FREM3 FREM1 FREM2	4.72e-06	10	120	3	15345741
Pubmed	A family of splice variants of CstF-64 expressed in vertebrate nervous systems.	CSTF2 CSTF2T	1.18e-05	2	120	2	19284619
Pubmed	Recognition of GU-rich polyadenylation regulatory elements by human CstF-64 protein.	CSTF2 CSTF2T	1.18e-05	2	120	2	12773396
Pubmed	Polyadenylation proteins CstF-64 and tauCstF-64 exhibit differential binding affinities for RNA polymers.	CSTF2 CSTF2T	1.18e-05	2	120	2	17029590
Pubmed	Overexpression of Nedd9 is a prognostic marker of human gastric cancer.	PTK2 NEDD9	1.18e-05	2	120	2	24906654
Pubmed	Cyclic hydrodynamic pressure induced proliferation of bladder smooth muscle cells via integrin alpha5 and FAK.	ITGA5 PTK2	1.18e-05	2	120	2	24182341
Pubmed	EIF3C Promotes Lung Cancer Tumorigenesis by Regulating the APP/HSPA1A/LMNB1 Axis.	EIF3CL EIF3C	1.18e-05	2	120	2	36157221
Pubmed	Targeting of δ-catenin to postsynaptic sites through interaction with the Shank3 N-terminus.	SHANK3 CTNND1	1.18e-05	2	120	2	33115499
Pubmed	Overlapping and distinct functions of CstF64 and CstF64τ in mammalian mRNA 3' processing.	CSTF2 CSTF2T	1.18e-05	2	120	2	24149845
Pubmed	Developmental distribution of the polyadenylation protein CstF-64 and the variant tauCstF-64 in mouse and rat testis.	CSTF2 CSTF2T	1.18e-05	2	120	2	14681198
Pubmed	A homozygous mutation p.Arg2167Trp in FREM2 causes isolated cryptophthalmos.	FREM1 FREM2	1.18e-05	2	120	2	29688405
Pubmed	Elevated levels of the 64-kDa cleavage stimulatory factor (CstF-64) in lipopolysaccharide-stimulated macrophages influence gene expression and induce alternative poly(A) site selection.	CSTF2 CSTF2T	1.18e-05	2	120	2	16207706
Pubmed	Deletion of Ulk1 inhibits neointima formation by enhancing KAT2A/GCN5-mediated acetylation of TUBA/α-tubulin in vivo.	KAT2A ULK1	1.18e-05	2	120	2	33985412
Pubmed	High-resolution photocatalytic mapping of SARS-CoV-2 spike interactions on the cell surface.	PCDHGA4 PDPK1 FAM117B EIF3CL FREM2 RAB34 CELSR2 PVR	1.20e-05	307	120	8	37499664
Pubmed	The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.	MTF2 CHD7 KAT2A KDM6B BAZ2A UHRF1	1.84e-05	157	120	6	30186101
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	EPPK1 ANK3 CHD7 BCL9 PTK2 KIAA1671 NEDD9 ZNF469 AKAP13	1.94e-05	430	120	9	35044719
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	EPPK1 WDR33 DHX38 DIDO1 ZNF385A MSI2 SRRT DAZAP1 CSTF2 EIF3C SF3B2 CSTF2T	2.40e-05	807	120	12	22681889
Pubmed	Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.	DIP2B ANK3 DCTN1 SHANK3 PTK2 SYNJ1 CTNND1	2.79e-05	251	120	7	27507650
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	DIP2B ANK3 PATZ1 SIPA1L3 DIDO1 CHD7 BCL9 DCTN1 SHANK3 PTK2 CELSR2 SYNJ1 CTNND1	2.96e-05	963	120	13	28671696
Pubmed	Elevation of hsa-miR-7-5p level mediated by CtBP1-p300-AP1 complex targets ATXN1 to trigger NF-κB-dependent inflammation response.	ESRP1 DIDO1 DAZAP1 CES3 UHRF1 ATP5F1A	2.97e-05	171	120	6	36629882
Pubmed	A direct functional link between the multi-PDZ domain protein GRIP1 and the Fraser syndrome protein Fras1.	FREM3 FREM1 FREM2	3.15e-05	18	120	3	14730302
Pubmed	SND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9.	PATZ1 ESRP1 MSI2 SRRT DAZAP1 CSTF2 EIF3C	3.32e-05	258	120	7	37794589
Pubmed	Methyltransferase-like 21e inhibits 26S proteasome activity to facilitate hypertrophy of type IIb myofibers.	MTF2 DCTN1 EIF3CL SYNJ1 EIF3C SF3B2 ATP5F1A	3.41e-05	259	120	7	31162944
Pubmed	Src kinase determines the dynamic exchange of the docking protein NEDD9 (neural precursor cell expressed developmentally down-regulated gene 9) at focal adhesions.	PTK2 NEDD9	3.53e-05	3	120	2	25059660
Pubmed	Focal adhesion kinase modulates cell adhesion strengthening via integrin activation.	ITGA5 PTK2	3.53e-05	3	120	2	19297531
Pubmed	[Expression and Mechanism of KAT2A and CDK4/CDK6 in Children with Acute Leukemia].	KAT2A CDK4	3.53e-05	3	120	2	33067952
Pubmed	Par6 alpha interacts with the dynactin subunit p150 Glued and is a critical regulator of centrosomal protein recruitment.	DCTN1 PARD6A	3.53e-05	3	120	2	20719959
Pubmed	APC regulation of ESRP1 and p120-catenin isoforms in colorectal cancer cells.	ESRP1 CTNND1	3.53e-05	3	120	2	33237836
Pubmed	Serine 389 phosphorylation of 3-phosphoinositide-dependent kinase 1 by UNC-51-like kinase 1 affects its ability to regulate Akt and p70 S6kinase.	PDPK1 ULK1	3.53e-05	3	120	2	32317083
Pubmed	Beta 1-integrin-mediated cell signaling in T lymphocytes.	PTK2 NEDD9	3.53e-05	3	120	2	10808124
Pubmed	Expression of focal adhesion kinase and alpha5 and beta1 integrins in carcinomas and its clinical significance.	ITGA5 PTK2	3.53e-05	3	120	2	12174366
Pubmed	SET8 prevents excessive DNA methylation by methylation-mediated degradation of UHRF1 and DNMT1.	KMT5A UHRF1	3.53e-05	3	120	2	31400111
Pubmed	Focal adhesion kinase is essential for costamerogenesis in cultured skeletal muscle cells.	ITGA5 PTK2	3.53e-05	3	120	2	16533505
Pubmed	Cytoskeleton-dependent tyrosine phosphorylation of the p130(Cas) family member HEF1 downstream of the G protein-coupled calcitonin receptor. Calcitonin induces the association of HEF1, paxillin, and focal adhesion kinase.	PTK2 NEDD9	3.53e-05	3	120	2	10455189
Pubmed	In vivo fate mapping with SCL regulatory elements identifies progenitors for primitive and definitive hematopoiesis in mice.	AGER TAL1	3.53e-05	3	120	2	19631738
Pubmed	A novel Cas family member, HEPL, regulates FAK and cell spreading.	PTK2 NEDD9	3.53e-05	3	120	2	18256281
Pubmed	The overexpression of scaffolding protein NEDD9 promotes migration and invasion in cervical cancer via tyrosine phosphorylated FAK and SRC.	PTK2 NEDD9	3.53e-05	3	120	2	24058594
Pubmed	Hypoxia stimulates invasion and migration of human cervical cancer cell lines HeLa/SiHa through the Rab11 trafficking of integrin αvβ3/FAK/PI3K pathway-mediated Rac1 activation.	ITGA5 PTK2	3.53e-05	3	120	2	29358562
Pubmed	Expression of Fraser syndrome genes in normal and polycystic murine kidneys.	FREM3 FREM2	3.53e-05	3	120	2	21993971
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	ATP6V1B2 HIVEP2 ANK3 PPRC1 SIPA1L3 MYRIP POGZ KDM6B DCTN1 PTK2 DAZAP1 SYNJ1 EIF3C SF3B2 ATP5F1A	3.77e-05	1285	120	15	35914814
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	DIP2B HIVEP2 PATZ1 SIPA1L3 FAM117B KIAA1671 SRRT MYLK3 SYNJ1 AKAP13 CTNND1 WDR62	4.49e-05	861	120	12	36931259
Pubmed	Global phosphoproteome of HT-29 human colon adenocarcinoma cells.	EPPK1 EIF3CL EIF3C CTNND1	5.30e-05	59	120	4	16083285
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	ATP6V1B2 EPPK1 KIAA1671 SRRT DAZAP1 CSTF2 CKAP2L UHRF1 EIF3C CTNND1 SF3B2 ATP5F1A KIF22	5.55e-05	1024	120	13	24711643
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	ATP6V1B2 ZNF48 SIPA1L3 DHX38 DIDO1 CHD7 KAT2A ZNF385A AHDC1 KIAA1671 SRRT BAZ2A EIF3C ATP5F1A CSTF2T KIF22	5.84e-05	1497	120	16	31527615
Pubmed	WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.	EPPK1 WDR33 DIDO1 CHD7 POGZ DCTN1 UHRF1 KIF22	7.04e-05	394	120	8	27248496
Pubmed	The role of FREM2 and FRAS1 in the development of congenital diaphragmatic hernia.	FREM1 FREM2	7.05e-05	4	120	2	29618029
Pubmed	Human enhancer of filamentation 1, a novel p130cas-like docking protein, associates with focal adhesion kinase and induces pseudohyphal growth in Saccharomyces cerevisiae.	PTK2 NEDD9	7.05e-05	4	120	2	8668148
Pubmed	Deficiency of FRAS1-related extracellular matrix 1 (FREM1) causes congenital diaphragmatic hernia in humans and mice.	FREM1 FREM2	7.05e-05	4	120	2	23221805
Pubmed	Frem1 activity is regulated by Sonic hedgehog signaling in the cranial neural crest mesenchyme during midfacial morphogenesis.	FREM1 FREM2	7.05e-05	4	120	2	36495293
Pubmed	The gene for a variant form of the polyadenylation protein CstF-64 is on chromosome 19 and is expressed in pachytene spermatocytes in mice.	CSTF2 CSTF2T	7.05e-05	4	120	2	11113135
Pubmed	αvβ5 Integrin/FAK/PGC-1α Pathway Confers Protective Effects on Retinal Pigment Epithelium.	ITGA5 PTK2	7.05e-05	4	120	2	26244551
Pubmed	Signalling involving MET and FAK supports cell division independent of the activity of the cell cycle-regulating CDK4/6 kinases.	PTK2 CDK4	7.05e-05	4	120	2	31296956
Pubmed	Segmental and restricted localization pattern of Fras1 in the developing meningeal basement membrane in mouse.	FREM3 FREM2	7.05e-05	4	120	2	24101214
Pubmed	Squamous cell carcinoma cell aggregates escape suspension-induced, p53-mediated anoikis: fibronectin and integrin alphav mediate survival signals through focal adhesion kinase.	ITGA5 PTK2	7.05e-05	4	120	2	15331608
Pubmed	Three-amino-acid-loop-extension homeodomain factor Meis3 regulates cell survival via PDK1.	PDPK1 MEIS3	7.05e-05	4	120	2	21059917
Pubmed	DPP-4 exacerbates LPS-induced endothelial cells inflammation via integrin-α5β1/FAK/AKT signaling.	ITGA5 PTK2	7.05e-05	4	120	2	38184221
Pubmed	Interaction between the Ret finger protein and the Int-6 gene product and co-localisation into nuclear bodies.	EIF3CL EIF3C	7.05e-05	4	120	2	10504338
Pubmed	Deletion of PDK1 in oligodendrocyte lineage cells causes white matter abnormality and myelination defect in the central nervous system.	PDPK1 OLIG1	7.05e-05	4	120	2	33276084
Pubmed	Tyrosine phosphorylation of Crk-associated substrates by focal adhesion kinase. A putative mechanism for the integrin-mediated tyrosine phosphorylation of Crk-associated substrates.	PTK2 NEDD9	7.05e-05	4	120	2	9360983
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	ATP6V1B2 ANK3 SIPA1L3 DHX38 KIAA1549 ITGA5 KIAA1671 SLC12A4 CSTF2 EIF3C CTNND1 ATP5F1A KIF22	7.07e-05	1049	120	13	27880917
Pubmed	Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.	TRMT112 PIDD1 DIDO1 FAM117B BCL9 AHDC1 FREM1 FREM2 KLLN CTAGE8 UHRF1 EIF3C CTNND1 ROBO3	7.99e-05	1215	120	14	15146197
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	DIP2B DHX38 DIDO1 PTK2 SRRT FREM2 ANTXR1 AKAP13 ULK1 SF3B2	8.92e-05	650	120	10	38777146
Pubmed	Phospho-tyrosine dependent protein-protein interaction network.	MTF2 PDPK1 FAM117B SOCS6 AHDC1 PTK2 PARD6A OLIG1	9.28e-05	410	120	8	25814554
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	DIP2B WDR33 TRMT112 CECR2 DIDO1 CHD7 POGZ AHDC1 SRRT CSTF2 EIF3C SF3B2 CSTF2T	9.64e-05	1082	120	13	38697112
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	ANK3 PPRC1 DHX38 ESRP1 DIDO1 NFKBIZ CHD7 PABPN1L DCTN1 SYNJ1 CSTF2 HMGXB3 ATP5F1A	9.82e-05	1084	120	13	11544199
Pubmed	ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.	ATP6V1B2 SIPA1L3 KIAA1671 SRRT DAZAP1 CSTF2 UHRF1 EIF3C CTNND1 KIF22	1.01e-04	660	120	10	32780723
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	CHD7 POGZ RBBP8NL DCTN1 KIAA1671 SYNJ1 CSTF2T WDR62	1.06e-04	418	120	8	34709266
Pubmed	Genetic loci influencing natural variations in femoral bone morphometry in mice.	COL11A1 EIF3CL EIF3C	1.10e-04	27	120	3	11518254
Pubmed	Neuregulin-1/glial growth factor stimulates Schwann cell migration by inducing α5 β1 integrin-ErbB2-focal adhesion kinase complex formation.	ITGA5 PTK2	1.17e-04	5	120	2	24256316
Pubmed	Effect of advanced glycation end products on lectin-like oxidized low density lipoprotein receptor-1 expression in endothelial cells.	PDPK1 AGER	1.17e-04	5	120	2	22863784
Pubmed	FAK, talin and PIPKIγ regulate endocytosed integrin activation to polarize focal adhesion assembly.	ITGA5 PTK2	1.17e-04	5	120	2	27043085
Pubmed	Targeting PDK1 with dichloroacetophenone to inhibit acute myeloid leukemia (AML) cell growth.	PDPK1 ULK1	1.17e-04	5	120	2	26593251
Pubmed	Nuclear focal adhesion kinase induces APC/C activator protein CDH1-mediated cyclin-dependent kinase 4/6 degradation and inhibits melanoma proliferation.	PTK2 CDK4	1.17e-04	5	120	2	35525274
Pubmed	Novel frem1-related mouse phenotypes and evidence of genetic interactions with gata4 and slit3.	FREM1 FREM2	1.17e-04	5	120	2	23536828
Pubmed	Characterizing WW domain interactions of tumor suppressor WWOX reveals its association with multiprotein networks.	WDR33 DIDO1 BCL9 DAZAP1 CSTF2 SF3B2	1.20e-04	220	120	6	24550385
Pubmed	Transcriptome of the inner circular smooth muscle of the developing mouse intestine: Evidence for regulation of visceral smooth muscle genes by the hedgehog target gene, cJun.	BOC EMILIN3 ITGA5 FREM2 TAL1	1.29e-04	140	120	5	26930384
Pubmed	A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition.	EMILIN3 KAT2A ADGRV1 SRRT FREM2 BAZ2A SF3B2 ATP5F1A	1.31e-04	431	120	8	33660365
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	PPRC1 WDR33 PCDHGA4 SIPA1L3 MYRIP CTAGE6 KAT2A DCTN1 SLC12A4 CTAGE8 CES3 CTAGE15 ANTXR1 ULK1 ATP5F1A	1.36e-04	1442	120	15	35575683
Pubmed	The N6-methyladenosine-mediated lncRNA WEE2-AS1 promotes glioblastoma progression by stabilizing RPN2.	TRMT112 DIDO1 DCTN1 PTK2 CTHRC1 CTNND1 KIF22	1.41e-04	325	120	7	36168628
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	COL11A1 KMT5A ZNF385A SHANK3 MSI2 SYNJ1 TRAPPC12 CKAP2L AKAP13 KIF22	1.43e-04	689	120	10	36543142
Pubmed	Network organization of the human autophagy system.	DIP2B PDPK1 EMILIN3 FREM1 TRAPPC12 ULK1 CTNND1 WDR62	1.44e-04	437	120	8	20562859
Pubmed	Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.	MYRIP SHANK3 CELSR2 BAZ2A AGER TAL1 KIF22	1.52e-04	329	120	7	17474147
Pubmed	Tagging genes with cassette-exchange sites.	DIDO1 PTK2 EIF3CL MSI2 AKAP13 EIF3C KIF22	1.70e-04	335	120	7	15741177
Pubmed	Single-Cell Transcriptomics Reveals Regulators of Neuronal Migration and Maturation During Brain Development.	CELSR2 CDH8	1.75e-04	6	120	2	29551912
Pubmed	New loci associated with central cornea thickness include COL5A1, AKAP13 and AVGR8.	ZNF469 AKAP13	1.75e-04	6	120	2	20719862
Pubmed	Mild recessive mutations in six Fraser syndrome-related genes cause isolated congenital anomalies of the kidney and urinary tract.	FREM1 FREM2	1.75e-04	6	120	2	24700879
Pubmed	Osteoprotegerin Disruption Attenuates HySu-Induced Pulmonary Hypertension Through Integrin αvβ3/FAK/AKT Pathway Suppression.	ITGA5 PTK2	1.75e-04	6	120	2	28077433
Interaction	FAM168B interactions	PATZ1 POGZ NEDD9 CSTF2 CSTF2T	1.91e-05	58	114	5	int:FAM168B
Interaction	CTAGE1 interactions	CTAGE6 CTAGE8 CTAGE15	2.06e-05	10	114	3	int:CTAGE1
Interaction	NXPH2 interactions	ADGRV1 FREM2 CELSR2 CTHRC1	3.50e-05	33	114	4	int:NXPH2
Interaction	TSC1 interactions	PATZ1 POGZ KAT2A SHANK3 PTK2 DAZAP1 CELSR2 TRAPPC12 CSTF2 CDK4	4.40e-05	366	114	10	int:TSC1
Interaction	MAPK8IP3 interactions	ANK3 KAT2A DCTN1 SHANK3 PTK2	4.79e-05	70	114	5	int:MAPK8IP3
Interaction	CEACAM8 interactions	MBTPS1 KIAA1549 EMILIN3 ADGRV1 FREM2 CES3	5.92e-05	119	114	6	int:CEACAM8
Interaction	LCK interactions	DIP2B ANK3 KIAA1549 SOCS6 PTK2 KIAA1671 NEDD9 SYNJ1 CTNND1 ATP5F1A CSTF2T	6.42e-05	463	114	11	int:LCK
Interaction	TOP3B interactions	CRYBG2 EPPK1 HIVEP2 ZNF48 PPRC1 SIPA1L3 KAT2A ITGA5 KDM6B BCL9 DCTN1 AHDC1 GAS2L1 SLC12A4 CELSR2 SYNJ1 TRAPPC12 CTDP1 AKAP13 HMGXB3 ULK1	6.96e-05	1470	114	21	int:TOP3B
Cytoband	16p11.2	ZNF48 PRSS36 EIF3CL EIF3C KIF22	1.53e-04	191	120	5	16p11.2
Cytoband	16q22.1	SLC12A4 PARD6A CES3 CDH8	2.07e-04	110	120	4	16q22.1
Cytoband	7q35	CTAGE6 CTAGE8 CTAGE15	4.14e-04	55	120	3	7q35
Cytoband	Ensembl 112 genes in cytogenetic band chr7q35	CTAGE6 CTAGE8 CTAGE15	7.07e-04	66	120	3	chr7q35
Cytoband	16q24	MBTPS1 ZNF469	8.98e-04	17	120	2	16q24
Cytoband	Ensembl 112 genes in cytogenetic band chr16q22	DHX38 SLC12A4 PARD6A CES3	1.40e-03	183	120	4	chr16q22
Cytoband	1p21	COL11A1 CELSR2	1.80e-03	24	120	2	1p21
GeneFamily	CTAGE family	CTAGE6 CTAGE8 CTAGE15	5.20e-05	15	90	3	907
GeneFamily	RNA binding motif containing	PPRC1 ESRP1 PABPN1L MSI2 DAZAP1 CSTF2 CSTF2T	9.32e-05	213	90	7	725
GeneFamily	PHD finger proteins	MTF2 DIDO1 BAZ2A UHRF1	1.06e-03	90	90	4	88
Coexpression	PEREZ_TP53_TARGETS	SDHAF1 CRYBG2 EPPK1 ANK3 KIAA1549 PIDD1 EMILIN3 DIDO1 ADGRV1 ZNF385A ADCY1 AHDC1 KIAA1671 NEDD9 KIF9 CELSR2 FGFBP3 CES3 CTHRC1 ULK1	4.02e-07	1201	118	20	M4391
Coexpression	GSE11961_FOLLICULAR_BCELL_VS_PLASMA_CELL_DAY7_UP	NFKBIZ KAT2A SLC15A3 SAPCD2 SRRT DAZAP1 SLC34A1 NFKBIE	3.57e-06	200	118	8	M9314
Coexpression	GSE3982_DC_VS_TH1_UP	SOCS6 SLC15A3 PTK2 GAS2L1 NFKBIE CES3 ROBO3 TAL1	3.57e-06	200	118	8	M5481
Coexpression	GSE21379_WT_VS_SAP_KO_CD4_TCELL_DN	HIVEP2 CECR2 CHD7 SLC15A3 SAPCD2 BAZ2A UHRF1	3.39e-05	199	118	7	M7511
Coexpression	GSE5589_UNSTIM_VS_180MIN_LPS_AND_IL10_STIM_MACROPHAGE_UP	KMT5A SOCS6 SLC15A3 PTK2 PARD6A CTDP1 CTNND1	3.50e-05	200	118	7	M6604
Coexpression	GSE20715_WT_VS_TLR4_KO_6H_OZONE_LUNG_DN	SDHAF1 WDR33 ESRP1 NFKBIZ BCL9 DCTN1 RAB34	3.50e-05	200	118	7	M4352
ToppCell	PCW_10-12-Epithelial-Epithelial_proliferating-epi_proliferating2_(13)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	COL11A1 ESRP1 ADGRV1 SAPCD2 FREM2 CKAP2L IGSF9 WDR62	4.78e-08	191	119	8	39220f4a345e328f7fa4fd462a0abeea821b3e02
ToppCell	TCGA-Lung-Primary_Tumor\|TCGA-Lung / Sample_Type by Project: Shred V9	ESRP1 KAT2A SAPCD2 CTHRC1 CSTF2 CKAP2L UHRF1 KIF22	6.56e-08	199	119	8	d1d035e987280607266171094db5d6362efe1ad5
ToppCell	TCGA-Lung-Primary_Tumor-Lung_Carcinoma\|TCGA-Lung / Sample_Type by Project: Shred V9	ESRP1 KAT2A SAPCD2 CTHRC1 CSTF2 CKAP2L UHRF1 KIF22	6.56e-08	199	119	8	6748d4f76703360071d5f2026d9d06bf30ccfb6d
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Oligo-OPC\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	COL11A1 CECR2 CHD7 SAPCD2 ADARB2 FREM2 OLIG1	6.04e-07	182	119	7	8a8b08ac4bb3cba3541dbe234e088703842285b9
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Oligo-OPC-OPC_L1-6_MYT1\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	COL11A1 CECR2 CHD7 SAPCD2 ADARB2 FREM2 OLIG1	6.04e-07	182	119	7	e36766309c4d96a90d213ce37d3acef1029a3fdc
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Epithelial-neuronal_stem_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL11A1 KIAA1549 PIDD1 CKAP2L UHRF1 IGSF9 KIF22	7.24e-07	187	119	7	a2076599b33ae6750961b573bfebcb9036fa4ee8
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Epithelial-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL11A1 KIAA1549 PIDD1 CKAP2L UHRF1 IGSF9 KIF22	7.24e-07	187	119	7	38ee33295a21db4aae5ba085df033db9693e41c6
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Epithelial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL11A1 KIAA1549 PIDD1 CKAP2L UHRF1 IGSF9 KIF22	7.24e-07	187	119	7	dbcec24d2c852964736c78e9d81650bff5c455ae
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-4M-Proliferating-cycling_dorsal_progenitors\|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.	KMT5A SAPCD2 CKAP2L UHRF1 WDR62 KIF22 RNF26	1.06e-06	198	119	7	dada1c19a261c8e1090957cd7e37f2a43a9fe14f
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-2M-Proliferating\|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.	KMT5A SAPCD2 CKAP2L UHRF1 WDR62 KIF22 RNF26	1.10e-06	199	119	7	d8f904f531bfe091b7d8caaa147ea4a03d627995
ToppCell	10x_3'_v2v3-Neoplastic-Stem-like-NPC-like-NPC-like_Prolif-G\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	COL11A1 CHD7 CKAP2L UHRF1 OLIG1 WDR62 CDK4	1.10e-06	199	119	7	53b3d35767889a152f1f38e8f6f0ba8f7a7690f2
ToppCell	Control_saline-Epithelial_alveolar-AT_1-Differentiating_AT2\|Control_saline / Treatment groups by lineage, cell group, cell type	CECR2 ESRP1 FREM2 UBXN11 PVR CKAP2L IGSF9	1.14e-06	200	119	7	eac33be484dc443794e66e473f03e98406c2983e
ToppCell	5'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MYRIP NPDC1 ITGA5 SHANK3 KIAA1671 NEDD9 TAL1	1.14e-06	200	119	7	90061284a80d29a4ca6078f578e13d32b8cc80e1
ToppCell	PND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_G2M\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	EMILIN3 FREM1 CKAP2L WDR62 KIF22 RNF26	6.28e-06	169	119	6	563c267edaade0e5df192ad953801ef9768d4270
ToppCell	Mid-temporal_gyrus_(MTG)\|World / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GABRB1 COL11A1 ZC3H12B MEIS3 FREM3 CDH8	8.45e-06	178	119	6	ad187db4c40b9078d54dd915c143e0172b2f47b8
ToppCell	10x3'2.3-week_12-13-Myeloid_macrophage-stroma-erythroid_macrophage\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	BOC ZC3H12B MEIS3 ZNF469 LRRN4CL CELSR2	8.72e-06	179	119	6	c17ae394b855f01f8ca1765c416fd8b34a96e60b
ToppCell	5'-Adult-Appendix-Neuronal-Glial_mature\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GABRB1 COL11A1 SLC15A3 ADARB2 CELSR2 ANTXR1	9.29e-06	181	119	6	3aa81ac64d0cc9a74fbfa71e2176740548e7cd06
ToppCell	5'-Adult-Appendix-Neuronal-Glial_mature-Adult_Glia\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GABRB1 COL11A1 SLC15A3 ADARB2 CELSR2 ANTXR1	9.29e-06	181	119	6	997ba1be2824b00d684f2163d0114656ed11fa53
ToppCell	5'-Adult-Appendix-Neuronal\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GABRB1 COL11A1 SLC15A3 ADARB2 CELSR2 ANTXR1	9.29e-06	181	119	6	e6b7e8dd5c13cc10ba22f2f5a8c669486f934bdc
ToppCell	facs-Skin-Telogen-3m-Epithelial-actively_dividing_stem_cell\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SAPCD2 CKAP2L UHRF1 WDR62 KIF22 RNF26	1.08e-05	186	119	6	9feef5936985e936b3d88f9d1bb012abb6468570
ToppCell	facs-Skin-Telogen-3m-Epithelial-keratinocyte_stem_cell\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SAPCD2 CKAP2L UHRF1 WDR62 KIF22 RNF26	1.08e-05	186	119	6	89f5b06bc56674af304912d481ac697c7c870904
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Oligo-OPC\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	COL11A1 CECR2 CHD7 SAPCD2 ADARB2 OLIG1	1.12e-05	187	119	6	daff7ccd3f1924cf2b34d3aca3eccde245aaf371
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Oligo-OPC-OPC_L1-6_MYT1\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	COL11A1 CECR2 CHD7 SAPCD2 ADARB2 OLIG1	1.12e-05	187	119	6	5b7a1edee602e55d3400dc17dbb6b8aaa26defc0
ToppCell	Hippocampus-Macroglia-POLYDENDROCYTE\|Hippocampus / BrainAtlas - Mouse McCarroll V32	CHD7 SAPCD2 DAZAP1 CKAP2L UHRF1 CDK4	1.15e-05	188	119	6	8bd6f2cd1aadbd6f9ed31b160f59c1eff144e1dc
ToppCell	wk_15-18-Epithelial-Airway_epithelial_progenitor-epi-stalk_early\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	COL11A1 ESRP1 FREM3 FREM2 UHRF1 IGSF9	1.19e-05	189	119	6	a6c62b456982067ad4d224a2efa3919969000693
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-A\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ZNF48 BCL9 PRSS36 PARD6A BAZ2A PVR	1.22e-05	190	119	6	63018acb7ad80415e861643162abdc2e55968ee4
ToppCell	PCW_10-12-Endothelial-Endothelial_immature-endo_immature_arterial2_(6)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	NPDC1 ADCY1 SHANK3 KIAA1671 CTHRC1 TAL1	1.22e-05	190	119	6	7ba2be2630183df86de21689289a8620a4cd507e
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	COL11A1 ANK3 CECR2 ESRP1 ADGRV1 FREM2	1.26e-05	191	119	6	34cc997e4e5c727495f321e6807a84aa124da486
ToppCell	PCW_07-8.5-Epithelial-Epithelial_proliferating-epi_proliferating2_(13)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	COL11A1 ESRP1 ADGRV1 SAPCD2 FREM2 CKAP2L	1.30e-05	192	119	6	25378b5e4b0cea8415ff125783511fc25a56fc00
ToppCell	facs-Marrow-KLS-3m-Hematologic-MPP_Fraction_B_+_C\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PATZ1 KIAA1549 KAT2A MSI2 TAL1 CDK4	1.30e-05	192	119	6	03dcd9405d3d76fc7455066ba5d83c09cd17072d
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_cycling-mes_proliferating2_(11)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	KMT5A SAPCD2 CKAP2L WDR62 KIF22 RNF26	1.30e-05	192	119	6	026f3e38970bea1e6e8d76a4e2becdfb8484b2ff
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Endothelial-blood_vessel_EC\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MYRIP NPDC1 ITGA5 SHANK3 KIAA1671 NEDD9	1.50e-05	197	119	6	f4834378d5d31560b4efe5dee0d5b5d11caeb10f
ToppCell	wk_15-18-Endothelial\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	NPDC1 ITGA5 SHANK3 KIAA1671 NEDD9 CTHRC1	1.55e-05	198	119	6	dcf453e22dba90c0ae349fa6c3d4c20758bb95af
ToppCell	5'-GW_trimst-2-SmallIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ITGA5 SAPCD2 SHANK3 NEDD9 CTHRC1 CKAP2L	1.55e-05	198	119	6	604fb20ca1aaf8f07067a8e1593a30ba335891f7
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_aging_sig-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SOCS6 ITGA5 KDM6B NEDD9 AKAP13 TAL1	1.59e-05	199	119	6	b0a906586e58009f5ed9272fc29ba28e49c85ee6
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-2M-Proliferating-cycling_dorsal_progenitors\|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.	KMT5A SAPCD2 CKAP2L WDR62 KIF22 RNF26	1.59e-05	199	119	6	ca17e8c0f5bc2c41ce28351a7418d934404e563b
ToppCell	TCGA-Breast-Primary_Tumor\|TCGA-Breast / Sample_Type by Project: Shred V9	COL11A1 ESRP1 CTHRC1 CKAP2L UHRF1 KIF22	1.59e-05	199	119	6	82f308d4b047db049fc5ce9ff60e26cf0e1255a5
ToppCell	3'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MYRIP NPDC1 ITGA5 SHANK3 KIAA1671 TAL1	1.59e-05	199	119	6	0d63da0afa93741c37609d879941de202d9ac86c
ToppCell	TCGA-Breast-Primary_Tumor-Breast_Carcinoma\|TCGA-Breast / Sample_Type by Project: Shred V9	COL11A1 ESRP1 CTHRC1 CKAP2L UHRF1 KIF22	1.59e-05	199	119	6	875ee4a85dfdfcaaf61c09ed65cebafc6acbbaf0
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW10-Stem_cells\|GW10 / Sample Type, Dataset, Time_group, and Cell type.	BOC SAPCD2 RAB34 CKAP2L WDR62 KIF22	1.64e-05	200	119	6	4c22a1f35ff496fa6af2ab171f2936785272bc06
ToppCell	Tracheal-NucSeq-Epithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ANK3 ESRP1 MYRIP ADGRV1 ADARB2 KIAA1671	1.64e-05	200	119	6	d3af0a706baf66e3f32e67b17dcfc31e5b32ce0e
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW26-Stem_cells-Neuroepithelial_cell\|GW26 / Sample Type, Dataset, Time_group, and Cell type.	SAPCD2 CTHRC1 CKAP2L OLIG1 WDR62 KIF22	1.64e-05	200	119	6	203b9a5de4430713da01b3331e69381db449a3a0
ToppCell	Non-neuronal-Dividing-IPC-IPC-div2\|World / Primary Cells by Cluster	COL11A1 CHD7 ADGRV1 CKAP2L UHRF1 CDK4	1.64e-05	200	119	6	4923d7a4f00853c4d76fc1cc0fa82d522a2302e7
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW26-Stem_cells\|GW26 / Sample Type, Dataset, Time_group, and Cell type.	SAPCD2 CTHRC1 CKAP2L OLIG1 WDR62 KIF22	1.64e-05	200	119	6	a854e19703dc920e48304541e2b06ed013292f3e
ToppCell	Non-neuronal-Dividing-IPC-IPC-div2-5\|World / Primary Cells by Cluster	COL11A1 CHD7 ADGRV1 CKAP2L UHRF1 CDK4	1.64e-05	200	119	6	dc1c1506823eaa105f1532c6b5d4efa14e788314
ToppCell	10x_3'_v2v3-Neoplastic-Stem-like-NPC-like-NPC-like_Prolif\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CTHRC1 CKAP2L UHRF1 WDR62 CDK4 KIF22	1.64e-05	200	119	6	cab374b7c56310329951c2ca44a7179ffa895b7d
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW10-Stem_cells-Neuroepithelial_cell\|GW10 / Sample Type, Dataset, Time_group, and Cell type.	BOC SAPCD2 RAB34 CKAP2L WDR62 KIF22	1.64e-05	200	119	6	0632b8d3a1be437f146bc86aae9646303e37a0bd
ToppCell	Striatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Drd1\|Striatum / BrainAtlas - Mouse McCarroll V32	ANKRD63 ITGA5 FREM3 ADARB2 ROBO3	4.56e-05	146	119	5	7b863f9bc63dc1afe015a18a70cd6ed0b71d1f09
ToppCell	E16.5-samps\|World / Age Group, Lineage, Cell class and subclass	ADARB2 AHDC1 UHRF1 CDK4 KIF22	5.02e-05	149	119	5	e94d075f68c1c70c89fab50b1b765b5dda650d09
ToppCell	BAL-Mild-Myeloid-cDC-cDC-cDC_4\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	PPRC1 KMT5A FAM117B DCTN1 FGFBP3	5.02e-05	149	119	5	a85a051e0d82430160967e72fa04b55f43e84513
ToppCell	BAL-Mild-Myeloid-cDC-cDC-cDC_4\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PPRC1 KMT5A FAM117B DCTN1 FGFBP3	5.18e-05	150	119	5	7a381f5ae94eba5eb60dcbf83416b4eb18c279ea
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-4M-Neuronal-midbrain/hindbrain_cells\|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.	NLRP12 PCDHGA4 PIDD1 FREM3 ADCY1	5.87e-05	154	119	5	df1b58a20af73fa79c6c069c0117a9ffd85b476f
ToppCell	Mild_COVID-19-Myeloid-TRAM2\|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）	NLRP12 MBTPS1 CECR2 UBXN11 ULK1	5.87e-05	154	119	5	ab648f6b29eb9e499e46cbdbaf3c5cf6b94d1f64
ToppCell	COVID-19-kidney-Epithelial_(EC)\|kidney / Disease (COVID-19 only), tissue and cell type	BOC ITGA5 ADARB2 SHANK3 TAL1	7.04e-05	160	119	5	0d4880f85565d8c540c94a8f8109147b3029279a
ToppCell	Adult-Endothelial-endothelial_cell_of_vein-D122\|Adult / Lineage, Cell type, age group and donor	MYRIP NPDC1 ITGA5 SHANK3 CDH8	7.04e-05	160	119	5	0cfe130606af433b2aa90e0a20b6c44659dd6fd4
ToppCell	VE-CD8-naive_CD4\|VE / Condition, Cell_class and T cell subcluster	RNF212 FAM117B PRSS36 CSTF2 CSTF2T	7.04e-05	160	119	5	255d2a150bfe19ee3d4d34533feb9c37ce73d225
ToppCell	LPS-IL1RA-Unknown-Endothelial-Monocytes-Macrophages\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HIVEP2 PIDD1 ZC3H12B DCTN1 SLC12A4	7.68e-05	163	119	5	6b11a3ada8725670d0489f404c8c2175ad3904e9
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_vein-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	NPDC1 ITGA5 SHANK3 SLC34A1 TAL1	8.37e-05	166	119	5	f7926ee266dcbf10df375cd921f1db5a2fa604f8
ToppCell	PND01-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NPDC1 LRRN4CL CTHRC1 CKAP2L UHRF1	8.37e-05	166	119	5	49103b75c3e08656c5774f56fd00d7bd53eefcfb
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SAPCD2 CKAP2L UHRF1 WDR62 KIF22	8.61e-05	167	119	5	50c29ea660bf07b890e4ac1a1985d0761d863dee
ToppCell	droplet-Heart-nan-24m-Hematologic-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIAA1549 CELSR2 CTDP1 UHRF1 KIF22	8.61e-05	167	119	5	bad33497ceeab968a7eb8a48b921c6f936390743
ToppCell	Substantia_nigra-Macroglia-POLYDENDROCYTE-P3-Tnr\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	SAPCD2 ZNF469 MYLK3 NFKBIE	8.74e-05	87	119	4	8ca87e4a332ef6f035b13e80dcc0110f32172c9a
ToppCell	Substantia_nigra-Macroglia-POLYDENDROCYTE-P3\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	SAPCD2 ZNF469 MYLK3 NFKBIE	8.74e-05	87	119	4	4ec3a9489981ed69061c1ca363271edf6a3635d2
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_G2M\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SAPCD2 CKAP2L UHRF1 WDR62 KIF22	8.86e-05	168	119	5	d35944fd9fea9934ce1e76b2b35d48e2300cca61
ToppCell	356C-Endothelial_cells-Endothelial-E\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	SDHAF1 DIDO1 QRICH2 ANTXR1 WDR62	9.11e-05	169	119	5	0425d2580ed325178f522c0093ff4623de6ce7a8
ToppCell	356C-Endothelial_cells-Endothelial-E-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	SDHAF1 DIDO1 QRICH2 ANTXR1 WDR62	9.11e-05	169	119	5	fec669968a77060bd77ee8695034e35a642c984f
ToppCell	E16.5-samps-Epithelial-Alveolar_epithelial_precursor-Uncommitted_AE_cell\|E16.5-samps / Age Group, Lineage, Cell class and subclass	ADARB2 FREM2 CELSR2 AGER CDH8	9.37e-05	170	119	5	5a64e05c263df915085988d881808221e2c0f2e2
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_bronchial_vessel-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	MYRIP KIAA1549 QRICH2 ADCY1 SHANK3	9.63e-05	171	119	5	1ae4b6a25bc9c1065cf5d95998ebcc70aee21ab5
ToppCell	343B-Lymphocytic-CD4_T-cell-Proliferating_T_cell\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	ZC3H12B SAPCD2 CKAP2L UHRF1 TAL1	9.63e-05	171	119	5	4ccd88cf812dd8bfdc55159c6f504e9c84e4f4fc
ToppCell	367C-Lymphocytic-NK_cells-Proliferating_NK_cell\|367C / Donor, Lineage, Cell class and subclass (all cells)	SAPCD2 ADARB2 CKAP2L WDR62 KIF22	9.63e-05	171	119	5	4ede6e916e593f208f2f8ccf82ef2335e061fc86
ToppCell	droplet-Thymus-nan-18m-Lymphocytic-DN3_thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MTF2 PATZ1 ZNF385A UHRF1 ROBO3	1.02e-04	173	119	5	5d7c53c6d1cdd385e44b79b82faec901747d1736
ToppCell	facs-Marrow-B-cells-18m-Lymphocytic-early_pro-B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HIVEP2 CECR2 ZC3H12B PABPN1L KIAA1671	1.04e-04	174	119	5	268be5e7d2a18b866770b7cdb966c3958c7e6534
ToppCell	facs-Marrow-B-cells-18m-Lymphocytic-early_pro_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HIVEP2 CECR2 ZC3H12B PABPN1L KIAA1671	1.04e-04	174	119	5	4cdf2eedc28d88d18241ee390092426fdf849e79
ToppCell	droplet-Lung-18m-Hematologic-Lymphocytic_NK_ILC-natural_killer_cell-proliferating_NK\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SAPCD2 CKAP2L UHRF1 WDR62 KIF22	1.10e-04	176	119	5	b17317ac41d3215db55a38cbd3366c0947f7a2a3
ToppCell	3'_v3-blood-Mast-Mast_cell_granulo-myelo\|blood / Manually curated celltypes from each tissue	KIAA1549 ZC3H12B SAPCD2 FREM1 TAL1	1.10e-04	176	119	5	d421b6b8e13894dbcf29548c0a6516c3dee8f9b1
ToppCell	wk_08-11-Mesenchymal-Chondrocyte\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	BOC COL11A1 EMILIN3 NPDC1 CTHRC1	1.10e-04	176	119	5	1af28b701c4598ce761f85adbd5d79e4918d265a
ToppCell	facs-Skin-Anagen-24m-Epithelial-actively_dividing_stem_cell\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SAPCD2 CKAP2L UHRF1 WDR62 KIF22	1.13e-04	177	119	5	8a0f0fbb06cdacb99a3fdba0da3e0494b891db4f
ToppCell	facs-Skin-Anagen-24m-Epithelial-keratinocyte_stem_cell\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SAPCD2 CKAP2L UHRF1 WDR62 KIF22	1.13e-04	177	119	5	e9d7682517fb30fd2ad535d59779d718a7024c13
ToppCell	TCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-6\|TCGA-Ovary / Sample_Type by Project: Shred V9	COL11A1 MEIS3 ITGA5 ZNF469 ANTXR1	1.16e-04	178	119	5	142879e9393e721f9b05a6bb46995c9d6d713c95
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.5\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ANK3 ADGRV1 MSI2 ULK1 CTNND1	1.19e-04	179	119	5	6e965e424eebef50f0202cff75f458be395cfca1
ToppCell	LPS_only-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	BOC ANK3 CECR2 ESRP1 ADGRV1	1.19e-04	179	119	5	fd2cbee532e7b44113410dca82aec7db1a7fb69f
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MYRIP FAM117B ADARB2 FREM1 MSI2	1.22e-04	180	119	5	cfc8bfbfd3617aabbb49f9730c29b673ca157e74
ToppCell	Hippocampus-Macroglia-POLYDENDROCYTE-P5\|Hippocampus / BrainAtlas - Mouse McCarroll V32	DAZAP1 CKAP2L UHRF1 IGSF9 CDK4	1.22e-04	180	119	5	44988c34861df359a68376500c42a64fbcc4b431
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NPDC1 ITGA5 SHANK3 KIAA1671 NEDD9	1.26e-04	181	119	5	9bfd93cf053beaee806cacdffd7abef02f94aec6
ToppCell	P28-Endothelial-proliferative_endothelial_cell-proliferative_endothelial_cell\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	PIDD1 SAPCD2 CKAP2L UHRF1 KIF22	1.26e-04	181	119	5	e482fd116c00ff4d8db7be3c06b1bd1ffa2d479d
ToppCell	P28-Endothelial-proliferative_endothelial_cell\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	PIDD1 SAPCD2 CKAP2L UHRF1 KIF22	1.26e-04	181	119	5	2be3d44619adb25d339e7a27b500a56e07e8de01
ToppCell	facs-Lung-Endomucin_-18m-Endothelial-Artery_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCDHGA4 MYRIP DIDO1 ZC3H12B CTHRC1	1.26e-04	181	119	5	4ea02344e1996f264dd5e14f3b19c8782ce41699
ToppCell	critical-Myeloid-Mast_cell\|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	MYRIP KIAA1549 ZC3H12B FREM1 TAL1	1.26e-04	181	119	5	f0d81ae74d3f32979624a94b2ef93774831a7970
ToppCell	wk_08-11-Mesenchymal-Chondrocyte-ASPN+_chondrocyte\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	BOC COL11A1 EMILIN3 NPDC1 CTHRC1	1.29e-04	182	119	5	0e52ba34e179d9bfaac7b49920b44c710b2b8dad
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Oligo-OPC\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	COL11A1 CHD7 SAPCD2 ADARB2 OLIG1	1.29e-04	182	119	5	3cc61f5f7ad4a81eba3daf65e122880b5af3adc0
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Oligo-OPC-OPC_L1-6_MYT1\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	COL11A1 CHD7 SAPCD2 ADARB2 OLIG1	1.29e-04	182	119	5	5d909e4b5f662905bf1be9c686bbddc3e87d2be9
ToppCell	Basal\|World / shred by cell class for mouse tongue	SIPA1L3 NEDD9 FREM2 SLC12A4 ANTXR1	1.32e-04	183	119	5	c6729a207526ff4aa48176207b9353176f631fea
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Neuronal-Glial_immature-cycling_ENCC/glia\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CHD7 ADGRV1 ADARB2 CKAP2L KIF22	1.32e-04	183	119	5	29b62dd542bc3f8df843998f577724f3818d4271
ToppCell	droplet-Lung-18m-Hematologic-myeloid-alveolar_macrophage-proliferating_alveolar_macrophage\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ESRP1 MEIS3 CKAP2L IGSF9 KIF22	1.32e-04	183	119	5	e91f00b75d43ee6293fdd4a129b789cd95f8d11a
ToppCell	10x_3'_v2v3-Neoplastic-Stem-like-NPC-like-NPC-like_OPC-G\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	COL11A1 CHD7 CTHRC1 OLIG1 CDK4	1.32e-04	183	119	5	8c8ce5a0d5535bef58ac10b7eb726f9c50af2ed8
ToppCell	Control-Epithelial_alveolar-AT_2\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ANK3 CECR2 ESRP1 ADGRV1 FREM2	1.36e-04	184	119	5	51e129b3fcc2df083eda05a3afe3717218b1e52b
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Epithelial-Bergmann_glial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GABRB1 SLC15A3 FREM1 KIF9 RAB34	1.36e-04	184	119	5	f6148e9591e8845cc62668e49fd52755257cdc7e
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Oligo-OPC-OPC_L1-6_MYT1\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	COL11A1 CHD7 SAPCD2 ADARB2 OLIG1	1.39e-04	185	119	5	efc5d564f8793c751ba640aef60f761e4b081d3f
ToppCell	Control-Epithelial_alveolar-AT_2-Differentiating_AT2\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ANK3 CECR2 ESRP1 ADGRV1 FREM2	1.39e-04	185	119	5	0d2add28ac1f4fa6de7699be009bf8391badaf4c
ToppCell	Brain_organoid-organoid_Kanton_Nature\|Brain_organoid / Sample Type, Dataset, Time_group, and Cell type.	ANK3 MTF2 CHD7 BAZ2A FGFBP3	1.39e-04	185	119	5	857c7ca8493e91ef1d0078ddafd6082020f9b169
Drug	Clebopride maleate [84370-95-6]; Up 200; 8.2uM; HL60; HT_HG-U133A	HIVEP2 ANK3 WDR33 PATZ1 SIPA1L3 SLC15A3 AHDC1 ZNF783	7.71e-06	195	117	8	1292_UP
Drug	2-propylpentanoic acid; Down 200; 200uM; PC3; HT_HG-U133A	PPRC1 PATZ1 SIPA1L3 PIDD1 KDM6B SYNJ1 CTDP1 AKAP13	7.71e-06	195	117	8	1214_DN
Drug	Propylthiouracil [51-52-5]; Down 200; 23.4uM; MCF7; HT_HG-U133A	SOCS6 FRMD1 AHDC1 SRRT SYNJ1 ANTXR1 ROBO3 CSTF2T	7.71e-06	195	117	8	4157_DN
Drug	Glutethimide, para-amino [125-84-8]; Up 200; 17.2uM; HL60; HT_HG-U133A	SIPA1L3 PIDD1 FRMD1 ZNF783 GAS2L1 PARD6A BAZ2A CES3	9.27e-06	200	117	8	2390_UP
Drug	Salbutamol [18559-94-9]; Down 200; 16.8uM; PC3; HT_HG-U133A	PIDD1 DIDO1 BCL9 NEDD9 PVR NFKBIE HMGXB3	5.97e-05	191	117	7	7376_DN
Drug	Chlorzoxazone [95-25-0]; Down 200; 23.6uM; HL60; HG-U133A	DHX38 DIDO1 POGZ BAZ2A TRAPPC12 CTDP1 AKAP13	6.58e-05	194	117	7	1416_DN
Drug	(-)-Isoproterenol hydrochloride [5984-95-2]; Down 200; 16.2uM; MCF7; HT_HG-U133A	PATZ1 SIPA1L3 PIDD1 KDM6B PARD6A PVR WDR62	6.58e-05	194	117	7	6833_DN
Drug	Dibucaine [85-79-0]; Down 200; 11.6uM; MCF7; HT_HG-U133A	PIDD1 FRMD1 SYNJ1 PVR ROBO3 CDH8 CSTF2T	6.58e-05	194	117	7	4149_DN
Drug	Indapamide [26807-65-8]; Down 200; 10.6uM; PC3; HT_HG-U133A	CRYBG2 CHD7 ZNF783 NEDD9 BAZ2A AKAP13 CSTF2T	6.80e-05	195	117	7	3778_DN
Drug	Mevalonic-D, L acid lactone [674-26-0]; Down 200; 30.8uM; MCF7; HT_HG-U133A	EPPK1 PATZ1 SIPA1L3 KDM6B BCL9 ZNF783 NEDD9	6.80e-05	195	117	7	3459_DN
Drug	Dobutamine hydrochloride [49745-95-1]; Down 200; 11.8uM; MCF7; HT_HG-U133A	SIPA1L3 SOCS6 NEDD9 SRRT BAZ2A ANTXR1 WDR62	7.02e-05	196	117	7	3206_DN
Drug	2-propylpentanoic acid; Down 200; 200uM; MCF7; HT_HG-U133A	MTF2 KAT2A KDM6B ZNF783 NEDD9 SRRT PVR	7.02e-05	196	117	7	5574_DN
Drug	Ethamsylate [2624-44-4]; Down 200; 15.2uM; MCF7; HT_HG-U133A	SDHAF1 SIPA1L3 KAT2A BCL9 AHDC1 PARD6A AKAP13	7.25e-05	197	117	7	7335_DN
Drug	Penbutolol sulfate [38363-32-5]; Down 200; 5.8uM; HL60; HT_HG-U133A	SIPA1L3 KDM6B GAS2L1 PVR CES3 ULK1 CTNND1	7.25e-05	197	117	7	2972_DN
Drug	Zidovudine, AZT [30516-87-1]; Down 200; 15uM; MCF7; HT_HG-U133A	HIVEP2 SIPA1L3 SOCS6 BCL9 PVR ANTXR1 AKAP13	7.25e-05	197	117	7	3211_DN
Drug	2-propylpentanoic acid; Down 200; 50uM; PC3; HT_HG-U133A	BCL9 BAZ2A PVR CTDP1 AKAP13 HMGXB3 CTNND1	7.25e-05	197	117	7	1222_DN
Drug	Doxylamine succinate [562-10-7]; Down 200; 10.2uM; MCF7; HT_HG-U133A	ANK3 PATZ1 SIPA1L3 SOCS6 PVR CTDP1 WDR62	7.25e-05	197	117	7	1473_DN
Drug	Convolamine hydrochloride [500-56-1]; Down 200; 11.8uM; MCF7; HT_HG-U133A	MTF2 SIPA1L3 PIDD1 DIDO1 KDM6B NEDD9 PARD6A	7.25e-05	197	117	7	7230_DN
Drug	chlorpromazine hydrochloride; Down 200; 1uM; HL60; HT_HG-U133A	SIPA1L3 AHDC1 PTK2 ZNF783 ULK1 CTNND1 WDR62	7.49e-05	198	117	7	6176_DN
Drug	Bisoprolol fumarate; Down 200; 9uM; HL60; HT_HG-U133A	HIVEP2 DHX38 PIDD1 KDM6B DCTN1 BAZ2A CSTF2T	7.49e-05	198	117	7	1287_DN
Drug	Bacampicillin hydrochloride [37661-08-8]; Down 200; 8uM; PC3; HT_HG-U133A	SIPA1L3 POGZ ADCY1 CELSR2 CES3 ULK1 CSTF2T	7.49e-05	198	117	7	4592_DN
Drug	Piperacetazine [3819-00-9]; Down 200; 9.8uM; HL60; HT_HG-U133A	PIDD1 AHDC1 PTK2 SRRT GAS2L1 CTDP1 CTNND1	7.73e-05	199	117	7	6152_DN
Drug	Karakoline [39089-30-0]; Down 200; 10.6uM; PC3; HT_HG-U133A	PATZ1 PIDD1 SRRT PVR CTDP1 AKAP13 WDR62	7.73e-05	199	117	7	4297_DN
Drug	ICI 182,780; Down 200; 1uM; PC3; HT_HG-U133A	SDHAF1 BCL9 ADCY1 AHDC1 SYNJ1 PVR CTDP1	7.73e-05	199	117	7	1205_DN
Drug	Cephapirin sodium salt [24356-60-3]; Up 200; 9uM; MCF7; HT_HG-U133A	CRYBG2 PIDD1 FRMD1 SRRT SLC34A1 TAL1 WDR62	7.73e-05	199	117	7	6790_UP
Drug	gemcitabine	ANK3 PDPK1 PTK2 NEDD9 NFKBIE CTHRC1 UHRF1 ANTXR1	7.89e-05	270	117	8	ctd:C056507
Disease	Marles Greenberg Persaud syndrome	FREM1 FREM2	1.48e-05	2	114	2	C1855425
Disease	Fraser syndrome (implicated_via_orthology)	FREM1 FREM2	8.83e-05	4	114	2	DOID:0090001 (implicated_via_orthology)
Disease	monocyte percentage of leukocytes	NLRP12 CRYBG2 CECR2 NPDC1 FAM117B CHD7 KDM6B NFKBIE CTDP1 AKAP13 HMGXB3	1.28e-04	731	114	11	EFO_0007989
Disease	mitogen-activated protein kinase 3 measurement	NLRP12 ZNF48	1.47e-04	5	114	2	EFO_0020579
Disease	immature granulocyte measurement	NLRP12 CHD7	3.07e-04	7	114	2	EFO_0803543
Disease	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 measurement	NLRP12 EMILIN3	3.07e-04	7	114	2	EFO_0020108
Disease	Unilateral agenesis of kidney	FREM1 FREM2	4.08e-04	8	114	2	C0266294
Disease	Tinnitus, wellbeing measurement	COL11A1 RNF212 PTK2 CDH8	5.34e-04	96	114	4	EFO_0007869, HP_0000360
Disease	uremia (biomarker_via_orthology)	PTK2 AGER	6.52e-04	10	114	2	DOID:4676 (biomarker_via_orthology)
Disease	diastolic blood pressure, systolic blood pressure	ANK3 PIDD1 EMILIN3 RBBP8NL BCL9 ADCY1 KIAA1671 TAL1 WDR62	1.19e-03	670	114	9	EFO_0006335, EFO_0006336
Disease	chronic kidney disease (is_implicated_in)	SLC34A1 AGER	1.31e-03	14	114	2	DOID:784 (is_implicated_in)
Disease	monocyte count	NLRP12 CRYBG2 MTF2 CECR2 DIDO1 ADGRV1 AHDC1 MSI2 UBXN11 NFKBIE CTDP1 CES3 AKAP13	1.78e-03	1320	114	13	EFO_0005091
Disease	eosinophil count	DIP2B HIVEP2 MTF2 PATZ1 KMT5A TRMT112 SIPA1L3 CHD7 KDM6B MSI2 ANTXR1 AKAP13 FUT5 OLIG1	1.81e-03	1488	114	14	EFO_0004842
Disease	IGF-1 measurement, IGFBP-3 measurement	ADCY1 CELSR2	1.94e-03	17	114	2	EFO_0004626, EFO_0004627
Disease	autism spectrum disorder (implicated_via_orthology)	CHD7 POGZ SHANK3 CTNND1	2.91e-03	152	114	4	DOID:0060041 (implicated_via_orthology)
Disease	intellectual disability (implicated_via_orthology)	HIVEP2 POGZ ITGA5	3.10e-03	75	114	3	DOID:1059 (implicated_via_orthology)
Disease	e-selectin measurement	NPDC1 CELSR2	3.25e-03	22	114	2	EFO_0004575

Protein segments in the cluster

Peptide	Gene	Start	Entry
VAPRPVSMENGLGPA	ZNF385A	136	Q96PM9
MEVPAAGRVPAEGAP	CTDP1	1	Q9Y5B0
GEQPGPSRRKRQPSM	CTDP1	826	Q9Y5B0
AMEQAEGTPRPPGVQ	PABPN1L	96	A6NDY0
DRVSVMRPQPGDTGR	ANTXR1	466	Q9H6X2
VRGPLFPVDTRGPFM	CTAGE6	701	Q86UF2
VRGPLFPVDTRGPFM	CTAGE8	701	P0CG41
VRGPLFPVDTRGPFM	CTAGE15	701	A4D2H0
MRPQGPAASPQRLRG	CTHRC1	1	Q96CG8
PMRQAGRPDLRPEGV	NEDD9	246	Q14511
IRRRMPGTDAPGIPA	DCTN1	801	Q14203
RRAGDPGEMPQSPTG	BAZ2A	1386	Q9UIF9
DGAPAGVREVMRAPP	AKAP13	1206	Q12802
TGQPSVRRPGMEIAE	ADGRV1	3886	Q8WXG9
GGVPDLPESFPVRMR	CELSR2	1526	Q9HCU4
NGRNVVVVFPPGEMP	AHDC1	526	Q5TGY3
EARGMDTRGPVPGPR	CSTF2	461	P33240
TPRGMQPERTRPKEG	DAZAP1	86	Q96EP5
PQVRPGSAGIPMEVG	CHD7	411	Q9P2D1
NQMRPAVPGTFGPLR	CECR2	646	Q9BXF3
APGIIPRISVREPMQ	ATP5F1A	176	P25705
QGRTPLMVAVGLPDP	ANKRD63	46	C9JTQ0
GVPPQPGTVVRMQGL	ESRP1	626	Q6NXG1
SVGRPPGPYTRKMIQ	MTF2	401	Q9Y483
ELMVTPARGGDPRPT	AGER	191	Q15109
QPKEVMFPPGTRGRA	MSI2	186	Q96DH6
PDRRGLEPTGMNQPG	QRICH2	221	Q9H0J4
MLPPSVPGRDQQGLE	QRICH2	276	Q9H0J4
GHAPGRARRTPMPQE	ADARB2	346	Q9NS39
QMTRPVVEGSLGSPP	KAT2A	211	Q92830
PGPGHLVPARMTVRG	ODF3B	66	A8MYP8
LVPARMTVRGTDGAP	ODF3B	71	A8MYP8
SEEMPSVARPRPVGG	KIAA1549	1801	Q9HCM3
LRGGVVMAAPPARPD	PCDHGA4	26	Q9Y5G9
AALVPNEERPMGTGP	FGFBP3	211	Q8TAT2
MAAQPPRPVGERSMG	LRRC34	1	Q8IZ02
QPPDPPRMGEVRIAA	LRRN4CL	81	Q8ND94
PVEPHMGVGRQQRGP	NFKBIZ	96	Q9BYH8
TAPGPEMVERRGPGR	KMT5A	66	Q9NQR1
DPGPAQVPQPAVRMR	KIAA1671	921	Q9BY89
QRPPSGAGSVTPERM	MBTPS1	886	Q14703
DPAQTGPRPARAAGM	NFKBIE	126	O00221
PMVVELRSRGAPVGS	FREM2	281	Q5SZK8
ERRAGEEPVPGPMTP	KDM6B	881	O15054
QQARIALRGPPGPMG	COL11A1	521	P12107
PMRAILPAPVNVGRG	HMGXB3	516	Q12766
TMLGSPEQPGVIPRA	KIF22	136	Q14807
APVRAEAVRRMPPGA	MYLK3	466	Q32MK0
GQMVLGEPRPEEPRG	FREM1	186	Q5H8C1
AMTVAIRRPGVPGAP	DIP2B	676	Q9P265
QPHVAVRPPGSVGMS	MEIS3	351	Q99687
RLRPDFGGPPVDVGM	GABRB1	51	P18505
MDRPGPGSARPGRTV	KLLN	1	B2CW77
KPGGSIRPGMVPVNR	KIF9	721	Q9HAQ2
NAVPGTMLRPQRPGD	OLIG1	11	Q8TAK6
PAVSPLPVRGGHVMR	SLC34A1	11	Q06495
PGLAPTGEMEVRNPL	NPDC1	291	Q9NQX5
GVDRLPMVAGPLSPQ	PATZ1	231	Q9HBE1
GMSVRVAPQGLERVP	PARD6A	176	Q9NPB6
IREQVMGSEPGPAFP	PRSS36	286	Q5K4E3
SPPQPGRVRMGAAEG	PANO1	176	I0J062
MDRTPDGRPQEVGRV	ITGA5	351	P08648
GSVRPRGQPTPGEML	RBBP8NL	371	Q8NC74
GERQPLLGPPESMRE	EIF3C	721	Q99613
MAVPPRGRGIDPART	FRMD1	1	Q8N878
VGERQPLLGPPESMR	EIF3CL	721	B5ME19
RPPVCPMPGVSVRAG	ADCY1	1086	Q08828
QEPGMQLSPGPLVRV	BOC	1091	Q9BWV1
PRGPRPVQSVVPEME	CDK4	251	P11802
SPVPGSERRGSRPEM	GAS2L1	306	Q99501
GGPGSRLQPMRATVP	FAM117B	26	Q6P1L5
IPPQMRPRGMAADVG	BCL9	1396	O00512
RQVSRMVPPVVVGSP	CRYBG2	211	Q8N1P7
SRGGLVGQAPMPVPE	DIDO1	1596	Q9BTC0
ANPPPMVEGEGLASR	ANK3	1031	Q12955
GPVPLERGQVQMSDP	CSTF2T	296	Q9H0L4
QMSDPRAPIPRGPVT	CSTF2T	306	Q9H0L4
NRMTGGPRAPAVPVG	EMILIN3	211	Q9NT22
FMPRQGLAPVPNGVD	CDH8	706	P55286
SPAEVPAGSGRPVMV	CES3	131	Q6UWW8
MPAPRAREQPRVPGE	SLC15A3	1	Q8IY34
MESRGTPAGPPENVL	PPRC1	1016	Q5VV67
RTVQPVAMGPDGLPV	CTNND1	151	O60716
PPGATEEPRRVSMQV	PIDD1	481	Q9HB75
IRGGAENTPPRPSFM	FREM3	296	P0C091
RPGLMAVEPVTGAPN	FUT5	46	Q11128
VPMARCVSTGGRPPA	PVR	161	P15151
MRGIVNGAAPELPVP	ATP6V1B2	6	P21281
GAPPSPGVARREMEA	SYNJ1	1146	O43426
ELPGDGRMVQLSPPA	TAL1	111	P17542
RQGPAMDGTAAEPRP	PDPK1	46	O15530
VIGRIENGERLPMPP	PTK2	631	Q05397
GVPQVFSQMTPVRPG	POGZ	201	Q7Z3K3
QARVMVPGPRGEVPA	EPPK1	1191	P58107
APGAPQGDPMRVFSV	RNF26	306	Q9BY78
RDPPRQPSDMGSRVG	SIPA1L3	1396	O60292
AMGAFVRPRAPTGEP	SDHAF1	71	A6NFY7
MPHFTVVPVDGPRRG	SLC12A4	1	Q9UP95
GIIHVRGPMPPNRIS	SRRT	641	Q9BXP5
IGPIPRINGMPEVQD	CKAP2L	666	Q8IYA6
GPARISMISPPQDGR	RNF212	176	Q495C1
PPQDMGQIGVRTPLG	SF3B2	206	Q13435
MAPRPRVRAQPSGPS	ZNF48	526	Q96MX3
PDSMGGPVPRQRLQL	YIF1A	256	O95070
MAGAAMAERGRVPPP	SAPCD2	1	Q86UD0
TSMQDPVREGRGIPP	SHANK3	801	Q9BYB0
LAVPGTEGRPEPVAM	TRAPPC12	251	Q8WVT3
TEGRPEPVAMRGPQA	TRAPPC12	256	Q8WVT3
PESGRMFPISRGIPN	TRMT112	101	Q9UI30
GEMTPPLQGPRARFR	ROBO3	1236	Q96MS0
QMGRRTPAQVPGVDR	FAM90A2P	346	Q658T7
TPGRKEQGEPMTPRR	DHX38	1206	Q92620
IGMPGVIRCPVRANP	IGSF9	336	Q9P2J2
PGATPQPGRALVMTR	ZC3H12B	686	Q5HYM0
GEQPPRLATLGPGVM	ZNF469	2661	Q96JG9
RRRVAMPGSAPGPGE	ZNF469	3446	Q96JG9
VMAGVPARRGQSSPP	WDR62	21	O43379
ERPGEGSPMVDNPMR	UHRF1	281	Q96T88
EMRGPQEIRGMQGPP	WDR33	826	Q9C0J8
QVRAPIPMVPVGGIQ	HIVEP2	2221	P31629
SPMEVSAVPPQVGGR	SOCS6	246	O14544
PSPQGAEMRGGRSPR	ULK1	521	O75385
LPSEPMNPGRRGIRI	UBXN11	16	Q5T124
QAQGMPRVRAGEPRP	ZNF783	316	Q6ZMS7
RPEPPRTVVMQGAAG	NLRP12	206	P59046
MVGQPQPRDDVGSPR	RAB34	1	P0DI83
QVPPDRQKGMFPRGT	MYRIP	671	Q8NFW9