Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionvoltage-gated sodium channel activity

SCN1A SCN3A SCN4A SCN8A SCN9A

3.47e-1026305GO:0005248
GeneOntologyMolecularFunctionsodium ion binding

SCN1A SCN3A SCN8A SCN9A

4.10e-0914304GO:0031402
GeneOntologyMolecularFunctionsodium channel activity

SCN1A SCN3A SCN4A SCN8A SCN9A

1.33e-0852305GO:0005272
GeneOntologyMolecularFunctionalkali metal ion binding

SCN1A SCN3A SCN8A SCN9A

6.05e-0826304GO:0031420
GeneOntologyMolecularFunctionsodium ion transmembrane transporter activity

SCN1A SCN3A SCN4A SCN8A SCN9A

5.20e-06171305GO:0015081
GeneOntologyMolecularFunctionmonoatomic cation channel activity

SCN1A SCN3A SCN4A SCN8A SCN9A

1.45e-04343305GO:0005261
GeneOntologyMolecularFunctionmonoatomic ion channel activity

SCN1A SCN3A SCN4A SCN8A SCN9A

5.57e-04459305GO:0005216
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

SCN1A SCN3A SCN4A SCN8A SCN9A

5.90e-04465305GO:0046873
GeneOntologyMolecularFunctionchannel activity

SCN1A SCN3A SCN4A SCN8A SCN9A

1.02e-03525305GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

SCN1A SCN3A SCN4A SCN8A SCN9A

1.03e-03526305GO:0022803
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

SCN1A SCN3A SCN4A SCN8A SCN9A

2.23e-03627305GO:0022890
GeneOntologyMolecularFunctionintegrin binding

SYK ACTN2 ITGA9

2.26e-03175303GO:0005178
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

SCN1A SCN3A SCN4A SCN8A SCN9A

2.86e-03664305GO:0008324
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

SCN1A SCN3A SCN4A SCN8A SCN9A

5.04e-03758305GO:0015318
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

SCN1A SCN3A SCN4A SCN8A SCN9A

6.09e-03793305GO:0015075
GeneOntologyMolecularFunctionphosphatase binding

SYK HSF4 ANAPC4

7.13e-03264303GO:0019902
GeneOntologyMolecularFunctiontransmembrane transporter activity

SVOP SCN1A SCN3A SCN4A SCN8A SCN9A

7.34e-031180306GO:0022857
GeneOntologyBiologicalProcessmembrane depolarization during action potential

SCN1A SCN3A SCN4A SCN8A SCN9A

2.36e-0936325GO:0086010
GeneOntologyBiologicalProcesscardiac muscle cell action potential involved in contraction

SCN1A SCN3A SCN4A SCN8A SCN9A

3.94e-0862325GO:0086002
GeneOntologyBiologicalProcessneuronal action potential

SCN1A SCN3A SCN4A SCN8A SCN9A

4.27e-0863325GO:0019228
GeneOntologyBiologicalProcesscardiac muscle cell action potential

SCN1A SCN3A SCN4A SCN8A SCN9A

2.19e-0787325GO:0086001
GeneOntologyBiologicalProcesscardiac muscle cell contraction

SCN1A SCN3A SCN4A SCN8A SCN9A

3.06e-0793325GO:0086003
GeneOntologyBiologicalProcesstransmission of nerve impulse

SCN1A SCN3A SCN4A SCN8A SCN9A

7.73e-07112325GO:0019226
GeneOntologyBiologicalProcessmembrane depolarization

SCN1A SCN3A SCN4A SCN8A SCN9A

1.13e-06121325GO:0051899
GeneOntologyBiologicalProcessactin-mediated cell contraction

SCN1A SCN3A SCN4A SCN8A SCN9A

1.44e-06127325GO:0070252
GeneOntologyBiologicalProcessactin filament-based movement

SCN1A SCN3A SCN4A SCN8A SCN9A

3.60e-06153325GO:0030048
GeneOntologyBiologicalProcesscardiac muscle contraction

SCN1A SCN3A SCN4A SCN8A SCN9A

5.53e-06167325GO:0060048
GeneOntologyBiologicalProcessaction potential

SCN1A SCN3A SCN4A SCN8A SCN9A

1.36e-05201325GO:0001508
GeneOntologyBiologicalProcesssodium ion transmembrane transport

SCN1A SCN3A SCN4A SCN8A SCN9A

1.60e-05208325GO:0035725
GeneOntologyBiologicalProcessregulation of membrane potential

ACTN2 SCN1A WWP2 SCN3A SCN4A SCN8A SCN9A

1.93e-05559327GO:0042391
GeneOntologyBiologicalProcessstriated muscle contraction

SCN1A SCN3A SCN4A SCN8A SCN9A

1.97e-05217325GO:0006941
GeneOntologyBiologicalProcessmuscle contraction

ACTN2 SCN1A SCN3A SCN4A SCN8A SCN9A

3.03e-05400326GO:0006936
GeneOntologyBiologicalProcessactin filament-based process

ARPIN ACTN2 SCN1A SPTBN1 SCN3A SCN4A SCN8A SCN9A

5.78e-05912328GO:0030029
GeneOntologyBiologicalProcesssodium ion transport

SCN1A SCN3A SCN4A SCN8A SCN9A

6.09e-05275325GO:0006814
GeneOntologyBiologicalProcessresponse to toxic substance

GLYAT DDC SCN3A SCN8A SCN9A

7.70e-05289325GO:0009636
GeneOntologyBiologicalProcessheart contraction

SCN1A SCN3A SCN4A SCN8A SCN9A

8.90e-05298325GO:0060047
GeneOntologyBiologicalProcessheart process

SCN1A SCN3A SCN4A SCN8A SCN9A

1.06e-04309325GO:0003015
GeneOntologyBiologicalProcessmuscle system process

ACTN2 SCN1A SCN3A SCN4A SCN8A SCN9A

1.70e-04547326GO:0003012
GeneOntologyBiologicalProcessblood circulation

ITGA9 SCN1A SCN3A SCN4A SCN8A SCN9A

4.24e-04648326GO:0008015
GeneOntologyBiologicalProcessinorganic cation transmembrane transport

ACTN2 SCN1A WWP2 SCN3A SCN4A SCN8A SCN9A

4.40e-04922327GO:0098662
GeneOntologyBiologicalProcesspositive regulation of protein depolymerization

NES ACTN2

4.81e-0421322GO:1901881
GeneOntologyBiologicalProcesssensory perception of mechanical stimulus

LOXHD1 SCN1A SCN8A SCN9A

4.82e-04238324GO:0050954
GeneOntologyBiologicalProcessmonoatomic cation transmembrane transport

ACTN2 SCN1A WWP2 SCN3A SCN4A SCN8A SCN9A

5.00e-04942327GO:0098655
GeneOntologyBiologicalProcessregulation of protein depolymerization

NES ACTN2 SPTBN1

5.71e-04105323GO:1901879
GeneOntologyBiologicalProcessmetal ion transport

ACTN2 SCN1A WWP2 SCN3A SCN4A SCN8A SCN9A

7.15e-041000327GO:0030001
GeneOntologyBiologicalProcessinorganic ion transmembrane transport

ACTN2 SCN1A WWP2 SCN3A SCN4A SCN8A SCN9A

7.90e-041017327GO:0098660
GeneOntologyBiologicalProcesscirculatory system process

ITGA9 SCN1A SCN3A SCN4A SCN8A SCN9A

8.11e-04733326GO:0003013
GeneOntologyBiologicalProcessbehavioral response to pain

SCN3A SCN9A

1.12e-0332322GO:0048266
GeneOntologyBiologicalProcessmonoatomic ion transmembrane transport

ACTN2 SCN1A WWP2 SCN3A SCN4A SCN8A SCN9A

1.35e-031115327GO:0034220
GeneOntologyBiologicalProcessprotein depolymerization

NES ACTN2 SPTBN1

1.43e-03144323GO:0051261
GeneOntologyBiologicalProcessregulation of protein-containing complex disassembly

NES ACTN2 SPTBN1

1.43e-03144323GO:0043244
GeneOntologyBiologicalProcessmonoatomic cation transport

ACTN2 SCN1A WWP2 SCN3A SCN4A SCN8A SCN9A

1.68e-031157327GO:0006812
GeneOntologyBiologicalProcesspositive regulation of protein-containing complex disassembly

NES ACTN2

1.84e-0341322GO:0043243
GeneOntologyBiologicalProcessdetection of stimulus involved in sensory perception of pain

SCN1A SCN9A

2.02e-0343322GO:0062149
GeneOntologyCellularComponentvoltage-gated sodium channel complex

SCN1A SCN3A SCN4A SCN8A SCN9A

4.36e-1117335GO:0001518
GeneOntologyCellularComponentsodium channel complex

SCN1A SCN3A SCN4A SCN8A SCN9A

8.25e-1029335GO:0034706
GeneOntologyCellularComponentcation channel complex

SCN1A SCN3A SCN4A SCN8A SCN9A

3.16e-05235335GO:0034703
GeneOntologyCellularComponentaxon

WDFY3 DDC SCN1A SPTBN1 SCN3A SCN4A SCN8A SCN9A

5.67e-05891338GO:0030424
GeneOntologyCellularComponentplasma membrane protein complex

SYK ITGA9 SCN1A SCN3A SCN4A SCN8A SCN9A

1.86e-04785337GO:0098797
GeneOntologyCellularComponentmonoatomic ion channel complex

SCN1A SCN3A SCN4A SCN8A SCN9A

2.95e-04378335GO:0034702
GeneOntologyCellularComponentmain axon

SCN1A SPTBN1 SCN8A

3.71e-0489333GO:0044304
GeneOntologyCellularComponentnode of Ranvier

SCN1A SCN8A

4.51e-0420332GO:0033268
GeneOntologyCellularComponentsarcomere

ACTN2 SCN1A SPTBN1 SCN8A

6.13e-04249334GO:0030017
GeneOntologyCellularComponentmyofibril

ACTN2 SCN1A SPTBN1 SCN8A

8.64e-04273334GO:0030016
GeneOntologyCellularComponentaxon initial segment

SCN1A SCN8A

9.55e-0429332GO:0043194
GeneOntologyCellularComponentcontractile muscle fiber

ACTN2 SCN1A SPTBN1 SCN8A

1.08e-03290334GO:0043292
GeneOntologyCellularComponenttransmembrane transporter complex

SCN1A SCN3A SCN4A SCN8A SCN9A

1.28e-03523335GO:1902495
GeneOntologyCellularComponenttransporter complex

SCN1A SCN3A SCN4A SCN8A SCN9A

1.60e-03550335GO:1990351
GeneOntologyCellularComponentZ disc

ACTN2 SCN1A SCN8A

1.72e-03151333GO:0030018
GeneOntologyCellularComponentI band

ACTN2 SCN1A SCN8A

2.25e-03166333GO:0031674
HumanPhenoClonic seizure

SCN1A SPTBN1 SCN3A SCN8A SCN9A

6.52e-0781125HP:0020221
HumanPhenoComplex febrile seizure

SCN1A SCN8A SCN9A

5.50e-0616123HP:0011172
HumanPhenoInfection-related seizure

SCN1A SPTBN1 SCN3A SCN8A SCN9A

1.18e-05145125HP:0032892
HumanPhenoSeizure precipitated by febrile infection

SCN1A SPTBN1 SCN3A SCN8A SCN9A

1.18e-05145125HP:0032894
HumanPhenoFebrile seizure (within the age range of 3 months to 6 years)

SCN1A SPTBN1 SCN3A SCN8A SCN9A

1.18e-05145125HP:0002373
HumanPhenoMultifocal epileptiform discharges

SCN1A SPTBN1 SCN8A SCN9A

1.18e-0566124HP:0010841
HumanPhenoImpulsivity

SCN1A SPTBN1 SCN3A SCN8A SCN9A

1.34e-05149125HP:0100710
HumanPhenoFocal hemiclonic seizure

SCN1A SCN8A SCN9A

2.23e-0525123HP:0006813
HumanPhenoSimple febrile seizure

SCN1A SCN3A SCN8A

2.83e-0527123HP:0011171
HumanPhenoGeneralized clonic seizure

SCN1A SCN8A SCN9A

5.74e-0534123HP:0011169
HumanPhenoFocal clonic seizure

SCN1A SCN8A SCN9A

1.09e-0442123HP:0002266
HumanPhenoCyanosis

SCN1A SCN4A SCN8A SCN9A

1.14e-04117124HP:0000961
HumanPhenoEEG with focal epileptiform discharges

SCN1A SPTBN1 SCN8A SCN9A

1.17e-04118124HP:0011185
HumanPhenoFeeding difficulties in infancy

ACTN2 DDC SCN1A SPTBN1 SCN3A SCN4A SCN9A

1.32e-04594127HP:0008872
HumanPhenoPhotosensitive myoclonic seizure

SCN1A SCN9A

1.41e-048122HP:0001327
HumanPhenoCyanotic episode

SCN1A SCN9A

1.41e-048122HP:0200048
HumanPhenoFocal impaired awareness seizure

SCN1A SCN3A SCN8A SCN9A

1.51e-04126124HP:0002384
HumanPhenoSudden unexpected death in epilepsy

SCN1A SCN8A

2.27e-0410122HP:0033258
HumanPhenoEEG with generalized epileptiform discharges

SCN1A SPTBN1 SCN3A SCN8A SCN9A

2.35e-04270125HP:0011198
HumanPhenoPes valgus

SCN1A SCN4A SCN9A

2.58e-0456123HP:0008081
HumanPhenoLimited neck range of motion

SCN1A SCN9A

2.77e-0411122HP:0000466
HumanPhenoEpilepsia partialis continua

SCN1A SCN9A

3.31e-0412122HP:0012847
HumanPhenoFocal automatism seizure

SCN1A SCN8A

3.31e-0412122HP:0032898
HumanPhenoCompulsive behaviors

SCN1A SPTBN1 SCN8A SCN9A

3.63e-04158124HP:0000722
HumanPhenoGeneralized tonic seizure

SCN1A SCN8A SCN9A

3.84e-0464123HP:0010818
HumanPhenoDrooling

DDC SCN1A SPTBN1 SCN9A

3.90e-04161124HP:0002307
HumanPhenoGeneralized cerebral atrophy/hypoplasia

SCN1A SCN9A

3.91e-0413122HP:0007058
HumanPhenoExcessive salivation

DDC SCN1A SPTBN1 SCN9A

4.81e-04170124HP:0003781
HumanPhenoInterictal epileptiform activity

SCN1A SPTBN1 SCN3A SCN8A SCN9A

5.13e-04319125HP:0011182
HumanPhenoPhotosensitive tonic-clonic seizure

SCN1A SCN9A

5.25e-0415122HP:0007207
HumanPhenoFacial tics

SCN1A SCN9A

5.25e-0415122HP:0011468
HumanPhenoInterictal EEG abnormality

SCN1A SPTBN1 SCN3A SCN8A SCN9A

5.59e-04325125HP:0025373
HumanPhenoDysgenesis of the hippocampus

SCN1A SCN9A

5.99e-0416122HP:0025101
HumanPhenoHypsarrhythmia

SCN1A SPTBN1 SCN3A SCN8A

6.63e-04185124HP:0002521
HumanPhenoAtypical absence status epilepticus

SCN1A SCN9A

6.78e-0417122HP:0011151
HumanPhenoFocal motor status epilepticus

SCN1A SCN9A

6.78e-0417122HP:0032663
HumanPhenoFocal-onset seizure

SCN1A SPTBN1 SCN3A SCN8A SCN9A

7.47e-04346125HP:0007359
HumanPhenoVisually-induced seizure

SCN1A SCN9A

7.62e-0418122HP:0020216
HumanPhenoGeneralized non-convulsive status epilepticus without coma

SCN1A SCN9A

7.62e-0418122HP:0032860
HumanPhenoEEG abnormality

DDC SCN1A SPTBN1 SCN3A SCN8A SCN9A

7.89e-04548126HP:0002353
HumanPhenoNon-convulsive status epilepticus without coma

SCN1A SCN9A

9.44e-0420122HP:0032671
HumanPhenoEEG with spike-wave complexes

SCN1A SCN8A SCN9A

9.79e-0488123HP:0010850
HumanPhenoEEG with abnormally slow frequencies

SCN1A SCN3A SCN8A

9.79e-0488123HP:0011203
HumanPhenoRestricted or repetitive behaviors or interests

DDC SCN1A SPTBN1 SCN8A SCN9A

9.92e-04368125HP:0031432
HumanPhenoStatus epilepticus

SCN1A SCN3A SCN8A SCN9A

1.01e-03207124HP:0002133
HumanPhenoMyoclonus

DDC SCN1A SCN3A SCN8A SCN9A

1.03e-03371125HP:0001336
HumanPhenoTalipes valgus

SCN1A SCN9A

1.04e-0321122HP:0004684
HumanPhenoPerseverative thought

DDC SCN1A SPTBN1 SCN8A SCN9A

1.11e-03377125HP:0030223
HumanPhenoFocal sensory seizure

SCN1A SCN8A

1.14e-0322122HP:0011157
HumanPhenoReflex seizure

SCN1A SCN9A

1.14e-0322122HP:0020207
HumanPhenoRigidity

SCN1A SCN3A SCN8A SCN9A

1.15e-03214124HP:0002063
HumanPhenoAbnormality of salivation

DDC SCN1A SPTBN1 SCN9A

1.17e-03215124HP:0100755
HumanPhenoDisordered formal thought process

DDC SCN1A SPTBN1 SCN8A SCN9A

1.23e-03386125HP:0025769
HumanPhenoTibial torsion

SCN1A SCN9A

1.25e-0323122HP:0100694
HumanPhenoIntellectual disability, borderline

SCN3A SCN8A

1.48e-0325122HP:0006889
HumanPhenoEpileptic aura

SCN1A SCN8A

1.48e-0325122HP:0033348
HumanPhenoFeeding difficulties

ACTN2 DDC SCN1A SPTBN1 SCN3A SCN4A SCN8A SCN9A

1.51e-031168128HP:0011968
HumanPhenoAbnormal thought pattern

DDC SCN1A SPTBN1 SCN8A SCN9A

1.52e-03404125HP:5200269
HumanPhenoLimited knee extension

SCN1A SCN9A

1.73e-0327122HP:0003066
HumanPhenoStatus epilepticus without prominent motor symptoms

SCN1A SCN9A

1.73e-0327122HP:0031475
HumanPhenoTremor

DDC SCN1A SPTBN1 SCN3A SCN8A SCN9A

1.80e-03639126HP:0001337
HumanPhenoFocal aware seizure

SCN1A SCN9A

1.86e-0328122HP:0002349
HumanPhenoStatus epilepticus with prominent motor symptoms

SCN1A SCN9A

1.99e-0329122HP:0032658
HumanPhenoReduced vital capacity

ACTN2 SCN4A

1.99e-0329122HP:0002792
HumanPhenoDialeptic seizure

SCN1A SCN3A SCN8A SCN9A

2.08e-03251124HP:0011146
HumanPhenoDermatological manifestations of systemic disorders

SCN1A SPTBN1 SCN4A SCN8A SCN9A

2.12e-03435125HP:0001005
HumanPhenoAbnormal tongue physiology

DDC SCN1A SCN9A

2.13e-03115123HP:0030810
HumanPhenoProgressive gait ataxia

SCN1A SCN9A

2.13e-0330122HP:0007240
HumanPhenoProgressive ataxia

SCN1A SCN9A

2.13e-0330122HP:0001329
HumanPhenoAbnormal nervous system electrophysiology

DDC SCN1A SPTBN1 SCN3A SCN4A SCN8A SCN9A

2.14e-03924127HP:0001311
HumanPhenoDevelopmental regression

SCN1A SPTBN1 SCN3A SCN8A SCN9A

2.23e-03440125HP:0002376
HumanPhenoEpileptic encephalopathy

SCN1A SCN3A SCN8A

2.34e-03119123HP:0200134
HumanPhenoCogwheel rigidity

SCN1A SCN9A

2.43e-0332122HP:0002396
HumanPhenoAutistic behavior

DDC SCN1A SPTBN1 SCN3A SCN8A SCN9A

2.46e-03678126HP:0000729
HumanPhenoChoreoathetosis

DDC SCN1A SCN8A

2.58e-03123123HP:0001266
HumanPhenoObsessive-compulsive trait

SCN1A SCN9A

2.58e-0333122HP:0008770
HumanPhenoAbnormality of temperature sensation

SCN1A SCN9A

2.74e-0334122HP:0100772
HumanPhenoImpaired temperature sensation

SCN1A SCN9A

2.74e-0334122HP:0010829
HumanPhenoCalcaneovalgus deformity

SCN1A SCN9A

2.74e-0334122HP:0001848
HumanPhenoEdema

SYK ACTN2 SCN1A SPTBN1 SCN4A SCN9A

2.89e-03699126HP:0000969
HumanPhenoDeformed tarsal bones

SCN1A SCN9A

2.90e-0335122HP:0008119
HumanPhenoLimitation of knee mobility

SCN1A SCN9A

2.90e-0335122HP:0010501
HumanPhenoRecurrent maladaptive behavior

SYK DDC SCN1A SPTBN1 SCN3A SCN4A SCN8A SCN9A

3.05e-031293128HP:5200241
HumanPhenoLimitation of neck motion

SCN1A SCN9A

3.07e-0336122HP:0005986
MousePhenoakinesia

DDC SCN1A SCN4A

5.80e-0621243MP:0002690
MousePhenolethality during fetal growth through weaning, complete penetrance

SYK ACTN2 WDFY3 ITGA9 ATG13 SCN1A SPTBN1 SCN4A SCN8A SCN9A

2.19e-0512692410MP:0011111
DomainNa_channel_asu

SCN1A SCN3A SCN4A SCN8A SCN9A

3.14e-1210335IPR001696
DomainNa_trans_assoc

SCN1A SCN3A SCN4A SCN8A SCN9A

3.14e-1210335IPR010526
DomainNa_trans_assoc

SCN1A SCN3A SCN4A SCN8A SCN9A

3.14e-1210335PF06512
DomainNa_trans_cytopl

SCN1A SCN3A SCN8A SCN9A

1.21e-106334PF11933
DomainNa_trans_cytopl

SCN1A SCN3A SCN8A SCN9A

1.21e-106334IPR024583
DomainChannel_four-helix_dom

SCN1A SCN3A SCN4A SCN8A SCN9A

4.92e-0857335IPR027359
Domain-

SCN1A SCN3A SCN4A SCN8A SCN9A

4.92e-08573351.20.120.350
DomainIQ

SCN1A SCN3A SCN4A SCN8A SCN9A

1.50e-0771335PF00612
DomainIQ

SCN1A SCN3A SCN4A SCN8A SCN9A

2.92e-0781335SM00015
DomainIQ_motif_EF-hand-BS

SCN1A SCN3A SCN4A SCN8A SCN9A

4.95e-0790335IPR000048
DomainIQ

SCN1A SCN3A SCN4A SCN8A SCN9A

5.84e-0793335PS50096
DomainIon_trans_dom

SCN1A SCN3A SCN4A SCN8A SCN9A

1.61e-06114335IPR005821
DomainIon_trans

SCN1A SCN3A SCN4A SCN8A SCN9A

1.61e-06114335PF00520
DomainEF-hand-dom_pair

ACTN2 SCN1A SCN3A SCN8A SCN9A

1.38e-04287335IPR011992
DomainPNMA

PNMA5 PNMA1

1.65e-0411332PF14893
DomainPNMA

PNMA5 PNMA1

1.65e-0411332IPR026523
DomainActinin_actin-bd_CS

ACTN2 SPTBN1

7.48e-0423332IPR001589
DomainACTININ_2

ACTN2 SPTBN1

7.48e-0423332PS00020
DomainACTININ_1

ACTN2 SPTBN1

7.48e-0423332PS00019
DomainSpectrin

ACTN2 SPTBN1

7.48e-0423332PF00435
DomainSpectrin_repeat

ACTN2 SPTBN1

1.19e-0329332IPR002017
DomainARM-like

STAG3L3 WDFY3 MROH2B IPO11

1.26e-03270334IPR011989
DomainSpectrin/alpha-actinin

ACTN2 SPTBN1

1.45e-0332332IPR018159
DomainSPEC

ACTN2 SPTBN1

1.45e-0332332SM00150
DomainARM-type_fold

STAG3L3 WDFY3 MROH2B IPO11

2.88e-03339334IPR016024
DomainCH

ACTN2 SPTBN1

5.87e-0365332SM00033
DomainCH

ACTN2 SPTBN1

6.78e-0370332PF00307
DomainHEAT_REPEAT

MROH2B IPO11

6.78e-0370332PS50077
Domain-

WDFY3 MROH2B IPO11

6.95e-032223331.25.10.10
Domain-

ACTN2 SPTBN1

6.97e-03713321.10.418.10
DomainCH

ACTN2 SPTBN1

7.36e-0373332PS50021
DomainCH-domain

ACTN2 SPTBN1

7.75e-0375332IPR001715
PathwayREACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS

SCN1A SPTBN1 SCN3A SCN4A SCN8A SCN9A

8.86e-1231246M877
PathwayREACTOME_L1CAM_INTERACTIONS

ITGA9 SCN1A SPTBN1 SCN3A SCN4A SCN8A SCN9A

8.84e-10121247M872
PathwayREACTOME_PHASE_0_RAPID_DEPOLARISATION

SCN1A SCN3A SCN4A SCN8A SCN9A

1.79e-0932245M27455
PathwayREACTOME_MUSCLE_CONTRACTION

ACTN2 SCN1A SCN3A SCN4A SCN8A SCN9A

8.98e-07203246M5485
PathwayWP_ADHD_AND_AUTISM_ASD_PATHWAYS

DDC ATG13 SCN1A SCN3A SCN4A SCN8A SCN9A

1.81e-06367247M48346
PathwayREACTOME_CARDIAC_CONDUCTION

SCN1A SCN3A SCN4A SCN8A SCN9A

2.28e-06130245M27454
PathwayWP_DRAVET_SYNDROME

SCN1A SCN3A SCN8A

1.38e-0528243M45519
PathwayREACTOME_NERVOUS_SYSTEM_DEVELOPMENT

ITGA9 SCN1A SPTBN1 SCN3A SCN4A SCN8A SCN9A

3.42e-05575247M29853
PathwayREACTOME_NEPHRIN_FAMILY_INTERACTIONS

ACTN2 SPTBN1

6.88e-0423242M913
Pubmed

International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.

SCN1A SCN3A SCN4A SCN8A SCN9A

7.04e-14933516382098
Pubmed

A 'toothache tree' alkylamide inhibits Aδ mechanonociceptors to alleviate mechanical pain.

SCN1A SCN3A SCN8A SCN9A

1.01e-11633423652591
Pubmed

Expression pattern of neuronal and skeletal muscle voltage-gated Na+ channels in the developing mouse heart.

SCN1A SCN3A SCN4A SCN8A

8.43e-11933415746173
Pubmed

Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.

SCN1A SCN3A SCN8A SCN9A

4.77e-101333415123669
Pubmed

Mutations in the sodium channel genes SCN1A, SCN3A, and SCN9A in children with epilepsy with febrile seizures plus(EFS+).

SCN1A SCN3A SCN9A

7.78e-10333333895391
Pubmed

Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation.

SCN1A SCN3A SCN8A

3.11e-09433317537961
Pubmed

Sodium channel expression and transcript variation in the developing brain of human, Rhesus monkey, and mouse.

SCN1A SCN3A SCN8A

3.11e-09433335031483
Pubmed

Abnormal changes in voltage-gated sodium channels subtypes NaV1.1, NaV1.2, NaV1.3, NaV1.6 and CaM/CaMKII pathway in low-grade astrocytoma.

SCN1A SCN3A SCN8A

3.11e-09433329578003
Pubmed

A new sodium channel alpha-subunit gene (Scn9a) from Schwann cells maps to the Scn1a, Scn2a, Scn3a cluster of mouse chromosome 2.

SCN1A SCN3A SCN9A

7.77e-0953338812438
Pubmed

Early development of electrical excitability in the mouse enteric nervous system.

SCN3A SCN8A SCN9A

7.77e-09533322875929
Pubmed

Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels.

SCN3A SCN4A SCN8A

7.77e-09533317724025
Pubmed

Nav1.2 haplodeficiency in excitatory neurons causes absence-like seizures in mice.

SCN1A SCN3A SCN8A

1.70e-071233330175250
Pubmed

Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.

SCN1A SCN3A SCN4A SCN8A SCN9A

2.06e-0713933516985003
Pubmed

Reduction of Kcnt1 is therapeutic in mouse models of SCN1A and SCN8A epilepsy.

SCN1A SCN8A

8.73e-07233237901435
Pubmed

Aberrant regulation of a poison exon caused by a non-coding variant in a mouse model of Scn1a-associated epileptic encephalopathy.

SCN1A SCN8A

8.73e-07233233411788
Pubmed

State- and use-dependent block of muscle Nav1.4 and neuronal Nav1.7 voltage-gated Na+ channel isoforms by ranolazine.

SCN4A SCN9A

8.73e-07233218079277
Pubmed

An Scn1a epilepsy mutation in Scn8a alters seizure susceptibility and behavior.

SCN1A SCN8A

8.73e-07233226410685
Pubmed

Scn8a Antisense Oligonucleotide Is Protective in Mouse Models of SCN8A Encephalopathy and Dravet Syndrome.

SCN1A SCN8A

8.73e-07233231943325
Pubmed

Mapping of a FEB3 homologous febrile seizure locus on mouse chromosome 2 containing candidate genes Scn1a and Scn3a.

SCN1A SCN3A

8.73e-07233227690330
Pubmed

Sodium channel slow inactivation interferes with open channel block.

SCN8A SCN9A

8.73e-07233227174182
Pubmed

Correlations in timing of sodium channel expression, epilepsy, and sudden death in Dravet syndrome.

SCN1A SCN3A

8.73e-07233223965409
Pubmed

Electrophysiological Differences between the Same Pore Region Mutation in SCN1A and SCN3A.

SCN1A SCN3A

8.73e-07233224990319
Pubmed

Na+ current properties in islet α- and β-cells reflect cell-specific Scn3a and Scn9a expression.

SCN3A SCN9A

8.73e-07233225172946
Pubmed

Persistent Nav1.1 and Nav1.6 currents drive spinal locomotor functions through nonlinear dynamics.

SCN1A SCN8A

8.73e-07233237665666
Pubmed

The voltage-gated sodium channel Scn8a is a genetic modifier of severe myoclonic epilepsy of infancy.

SCN1A SCN8A

8.73e-07233217881658
Pubmed

Role of the hippocampus in Nav1.6 (Scn8a) mediated seizure resistance.

SCN1A SCN8A

2.62e-06333224704313
Pubmed

Voltage-gated sodium channels in taste bud cells.

SCN3A SCN9A

2.62e-06333219284629
Pubmed

Sodium channels SCN1A, SCN2A and SCN3A in familial autism.

SCN1A SCN3A

2.62e-06333212610651
Pubmed

The sorting receptor Rer1 controls Purkinje cell function via voltage gated sodium channels.

SCN1A SCN8A

2.62e-06333228117367
Pubmed

Reduced sodium current in Purkinje neurons from Nav1.1 mutant mice: implications for ataxia in severe myoclonic epilepsy in infancy.

SCN1A SCN8A

2.62e-06333217928448
Pubmed

SCN1A, SCN2A and SCN3A gene polymorphisms and responsiveness to antiepileptic drugs: a multicenter cohort study and meta-analysis.

SCN1A SCN3A

2.62e-06333223859570
Pubmed

Abnormal expression of voltage-gated sodium channels Nav1.7, Nav1.3 and Nav1.8 in trigeminal neuralgia.

SCN3A SCN9A

2.62e-06333219699781
Pubmed

Early expression of sodium channel transcripts and sodium current by cajal-retzius cells in the preplate of the embryonic mouse neocortex.

SCN1A SCN3A

2.62e-06333214973256
Pubmed

Multidrug resistance in epilepsy and polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, and SCN3A: correlation among phenotype, genotype, and mRNA expression.

SCN1A SCN3A

2.62e-06333218784617
Pubmed

Characterization of 5' untranslated regions of the voltage-gated sodium channels SCN1A, SCN2A, and SCN3A and identification of cis-conserved noncoding sequences.

SCN1A SCN3A

2.62e-06333217544618
Pubmed

Human Nav1.6 Channels Generate Larger Resurgent Currents than Human Nav1.1 Channels, but the Navβ4 Peptide Does Not Protect Either Isoform from Use-Dependent Reduction.

SCN1A SCN8A

2.62e-06333226182346
Pubmed

Variable patterns of mutation density among NaV1.1, NaV1.2 and NaV1.6 point to channel-specific functional differences associated with childhood epilepsy.

SCN1A SCN8A

2.62e-06333232845893
Pubmed

De novo SCN1A, SCN8A, and CLCN2 mutations in childhood absence epilepsy.

SCN1A SCN8A

2.62e-06333231054517
Pubmed

Human voltage-gated sodium channel mutations that cause inherited neuronal and muscle channelopathies increase resurgent sodium currents.

SCN4A SCN9A

2.62e-06333220038812
Pubmed

Comparison and optimization of in silico algorithms for predicting the pathogenicity of sodium channel variants in epilepsy.

SCN1A SCN8A

2.62e-06333228518218
Pubmed

GAPDH-mediated posttranscriptional regulations of sodium channel Scn1a and Scn3a genes under seizure and ketogenic diet conditions.

SCN1A SCN3A

2.62e-06333227816501
Pubmed

Expression of alternatively spliced sodium channel alpha-subunit genes. Unique splicing patterns are observed in dorsal root ganglia.

SCN8A SCN9A

2.62e-06333215302875
Pubmed

Neuronal voltage-gated ion channels are genetic modifiers of generalized epilepsy with febrile seizures plus.

SCN1A SCN8A

5.23e-06433221156207
Pubmed

Models for discovery of targeted therapy in genetic epileptic encephalopathies.

SCN1A SCN8A

5.23e-06433228742937
Pubmed

Association of sodium voltage-gated channel genes polymorphisms with epilepsy risk and prognosis in the Saudi population.

SCN1A SCN3A

5.23e-06433235801810
Pubmed

Dorsal root ganglia isolated from Nf1+/- mice exhibit increased levels of mRNA expression of voltage-dependent sodium channels.

SCN1A SCN9A

5.23e-06433222260870
Pubmed

Use of recombinant inbred strains for studying genetic determinants of responses to alcohol.

SCN1A SCN3A

5.23e-0643328974318
Pubmed

FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.

LOXHD1 LGI2 SPTBN1 ANAPC4 IPO11 SCN9A

6.60e-0649733636774506
Pubmed

Molecular determinants of voltage-gated sodium channel regulation by the Nedd4/Nedd4-like proteins.

WWP2 SCN3A

8.72e-06533215548568
Pubmed

Three brain sodium channel alpha-subunit genes are clustered on the proximal segment of mouse chromosome 2.

SCN1A SCN3A

8.72e-0653321679748
Pubmed

Case-control association study of polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, SCN3A, SCN1B, and SCN2B and epilepsy.

SCN1A SCN3A

8.72e-06533224337656
Pubmed

Contactin regulates the current density and axonal expression of tetrodotoxin-resistant but not tetrodotoxin-sensitive sodium channels in DRG neurons.

SCN8A SCN9A

1.31e-05633216029194
Pubmed

ELF a beta-spectrin is a neuronal precursor cell marker in developing mammalian brain; structure and organization of the elf/beta-G spectrin gene.

NES SPTBN1

1.31e-05633212149647
Pubmed

The human PNMA family: novel neuronal proteins implicated in paraneoplastic neurological disease.

PNMA5 PNMA1

1.31e-05633216214224
Pubmed

An animal model of oxaliplatin-induced cold allodynia reveals a crucial role for Nav1.6 in peripheral pain pathways.

SCN3A SCN8A

1.31e-05633223711479
Pubmed

Organization, sequence, chromosomal localization, and promoter identification of the mouse orphan nuclear receptor Nurr1 gene.

SCN3A SCN9A

1.31e-0563329143501
Pubmed

Latent membrane protein 2A of Epstein-Barr virus binds WW domain E3 protein-ubiquitin ligases that ubiquitinate B-cell tyrosine kinases.

SYK WWP2

1.83e-05733211046148
Pubmed

Tyrosine-phosphorylated and nonphosphorylated sodium channel beta1 subunits are differentially localized in cardiac myocytes.

SCN1A SCN8A

1.83e-05733215272007
Pubmed

Pain without nociceptors? Nav1.7-independent pain mechanisms.

SCN3A SCN9A

1.83e-05733224440715
Pubmed

Diagnostic yield of genetic testing in epileptic encephalopathy in childhood.

SCN1A SCN8A

1.83e-05733225818041
Pubmed

Significant determinants of mouse pain behaviour.

SCN3A SCN9A

2.44e-05833225101983
Pubmed

Interaction of muscle and brain sodium channels with multiple members of the syntrophin family of dystrophin-associated proteins.

SCN1A SCN4A

2.44e-0583329412493
Pubmed

Genetic mapping of the peripheral sodium channel genes, Scn9a and Scn10a, in the mouse.

SCN3A SCN9A

3.13e-0593328854872
Pubmed

Sodium channel Scn1b null mice exhibit prolonged QT and RR intervals.

SCN1A SCN8A

3.13e-05933217884088
Pubmed

Exclusion of two candidate genes, Spnb-2 and Dcd, for the wobbler spinal muscular atrophy gene on proximal mouse chromosome 11.

DDC SPTBN1

3.13e-0593328199405
Pubmed

Cell cycle deregulation and loss of stem cell phenotype in the subventricular zone of TGF-beta adaptor elf-/- mouse brain.

NES SPTBN1

3.91e-051033216884701
Pubmed

Report and abstracts of the Fourth International Workshop on Human Chromosome 2 Mapping 1996.

SCN1A SPTBN1 SCN3A

4.26e-05713338751373
Pubmed

Quantitative trait loci mapping of genes that influence the sensitivity and tolerance to ethanol-induced hypothermia in BXD recombinant inbred mice.

SCN1A SCN3A

5.73e-05123328169823
Pubmed

Confirmation of quantitative trait loci for alcohol preference in mice.

SCN1A SCN3A

9.10e-05153329726281
Pubmed

Primary cilia are critical for Sonic hedgehog-mediated dopaminergic neurogenesis in the embryonic midbrain.

NES DDC

1.99e-042233226542012
Pubmed

Transcriptional profiling of sequentially generated septal neuron fates.

NES LGI2

2.80e-042633234851821
Pubmed

Quantitative-trait loci analysis of cocaine-related behaviours and neurochemistry.

DDC SCN8A

2.80e-042633210591541
Pubmed

Nrg1 Regulates Cardiomyocyte Migration and Cell Cycle in Ventricular Development.

NES ACTN2

3.25e-042833237846569
Pubmed

Integrin linked kinase (ILK) is required for lens epithelial cell survival, proliferation and differentiation.

ACTN2 ITGA9

3.74e-043033224472646
Pubmed

Identification of new ciliary signaling pathways in the brain and insights into neurological disorders.

SVOP SCN1A SPTBN1 SCN9A

5.68e-0440533438187761
Pubmed

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

TUT1 ACTN2 PNMA1 DDC WWP2

6.31e-0474233526871637
Pubmed

Dynamic spatiotemporal gene expression in embryonic mouse thalamus.

NES DDC

7.00e-044133221192082
Pubmed

Defects During Mecp2 Null Embryonic Cortex Development Precede the Onset of Overt Neurological Symptoms.

NES SCN8A

8.43e-044533225979088
InteractionSCN5A interactions

SCN1A WWP2 SCN8A SCN9A

1.01e-0647334int:SCN5A
InteractionSCN11A interactions

SCN1A SCN8A SCN9A

1.80e-0615333int:SCN11A
Cytoband2q24

SCN3A SCN9A

2.74e-05113322q24
CytobandEnsembl 112 genes in cytogenetic band chr2q24

SCN1A SCN3A SCN9A

1.06e-04127333chr2q24
Cytoband4p15.2

LGI2 ANAPC4

1.87e-04283324p15.2
CytobandEnsembl 112 genes in cytogenetic band chr16q22

CES3 HSF4 WWP2

3.11e-04183333chr16q22
Cytoband16q22.1

CES3 WWP2

2.86e-0311033216q22.1
CytobandEnsembl 112 genes in cytogenetic band chr4p15

LGI2 ANAPC4

4.27e-03135332chr4p15
GeneFamilySodium voltage-gated channel alpha subunits

SCN1A SCN3A SCN4A SCN8A SCN9A

4.15e-1392551203
GeneFamilyParaneoplastic Ma antigens

PNMA5 PNMA1

1.00e-0411252671
ToppCell3'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ITGA9 SPTBN1 SCN3A IPO11 SCN9A

2.97e-07193335040f6bb42aa41d0921371fdda1cc0912c4fe1930
ToppCell3'-Parenchyma_lung-Endothelial-Lymphatic_EC|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ITGA9 SPTBN1 SCN3A IPO11 SCN9A

2.97e-07193335e468287c8b30c56d1de65e8347ade233ba6cf584
ToppCellLAM-Endothelial-LymEndo|Endothelial / Condition, Lineage and Cell class

REXO2 ITGA9 SCN3A IPO11 SCN9A

3.37e-07198335ba64b1c95dfaa995045239d412e725596f6c482e
ToppCell3'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating-Lymphatic_EC_differentiating_L.2.5.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ITGA9 SPTBN1 SCN3A SCN9A

8.86e-06178334ad3de3e03a401dac64431a541899445262246347
ToppCell5'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating-Lymphatic_EC_differentiating_L.2.5.1.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ITGA9 SPTBN1 SCN3A SCN9A

9.67e-0618233453c267ee327e116dbd89d5927ed3bdf78d25ee62
ToppCell5'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating-Lymphatic_EC_differentiating_L.2.5.1.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ITGA9 SPTBN1 SCN3A SCN9A

9.88e-061833344d16bfbadf2cd13008c35e23dd2b5b4ecf92ee11
ToppCellCOVID-19-Neuronal_cells|COVID-19 / group, cell type (main and fine annotations)

ITGA9 SPTBN1 SCN3A SCN9A

1.03e-0518533436ce23893915f5c380cca39b2c33a516edf31c3a
ToppCellCOVID-19-Neuronal_cells-Neuronal_cells|COVID-19 / group, cell type (main and fine annotations)

ITGA9 SPTBN1 SCN3A SCN9A

1.03e-051853344a095829992b39856a73bdfac03ee68b9aa0d3b8
ToppCell5'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ITGA9 SPTBN1 SCN3A SCN9A

1.05e-0518633440070d9cd20188ba49b32acfca9bc16256b38bf5
ToppCell3'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ITGA9 SPTBN1 SCN3A SCN9A

1.05e-0518633420340a5b5cc7f07386498a4ef937d6fbc9e347c4
ToppCellFetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

SVOP DDC SCN3A SCN8A

1.10e-05188334c4c3b21ab723b0e9beff9ec84f8d68485f771528
ToppCellNeuroendocrine-neuroendo-2-Calca|World / Class top

DDC SCN3A SCN8A SCN9A

1.12e-051893346baa9a74560121cc008bb8fa9b2b7a335b3aeee0
ToppCell367C-Endothelial_cells-Endothelial-F_(Lymphatics)-|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

REXO2 ITGA9 SCN3A SCN9A

1.19e-051923345f4f44f15d3a2846981e68296643a4634930a211
ToppCell367C-Endothelial_cells-Endothelial-F_(Lymphatics)|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

REXO2 ITGA9 SCN3A SCN9A

1.19e-051923345e709c0714e8eba27e03a6def0544256bedb3ced
ToppCellNeuroendocrine|World / Class top

DDC SCN3A SCN8A SCN9A

1.19e-051923340199da3ef9ddb6673e9aa41f346f374838aec182
ToppCellwk_15-18-Endothelial-Lymph_endothelial-Lymphatic_endo|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

REXO2 ITGA9 SCN3A IPO11

1.24e-05194334bc03d0f8dca9f4ba10db2f2274293f8b119e8951
ToppCell343B-Endothelial_cells-Endothelial-F_(Lymphatics)-|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

ITGA9 SCN3A IPO11 SCN9A

1.27e-05195334fc75f04eb475c8139cc5c35e6be22e73fb2be9e6
ToppCell343B-Endothelial_cells-Endothelial-F_(Lymphatics)|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

ITGA9 SCN3A IPO11 SCN9A

1.27e-0519533483d45ff5e5bc704448431149fffb2e4c1278f279
ToppCellwk_15-18-Endothelial-Lymph_endothelial|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

REXO2 ITGA9 SCN3A IPO11

1.29e-05196334ff627244d7f5fd6a2ec009dae32d3509f0e2d95e
ToppCellParenchyma_COVID-19-Endothelial-TX-Lymphatic|Parenchyma_COVID-19 / Sample group, Lineage and Cell type

ITGA9 SPTBN1 SCN3A SCN9A

1.37e-0519933488f33b8dcd837abfa1d12c28719e073a7da6e979
ToppCellLung_Parenchyma-Severe-Endothelial-Endothelial-Lymphatic|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ITGA9 SPTBN1 SCN3A SCN9A

1.37e-0519933464b19aff72e2a109cb5857cb248bd4712dd49b43
ToppCellLung_Parenchyma-Severe-Endothelial-Endothelial-Lymphatic-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ITGA9 SPTBN1 SCN3A SCN9A

1.37e-051993342b9e1e069b36b3a61cc3e384f4523687b0e03905
ToppCellParenchymal-10x5prime-Endothelial-Endothelia_lymphatic|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

ITGA9 SCN3A IPO11 SCN9A

1.37e-051993341587d24b19f5bb64a3b6cc1df87c7c472cf41672
ToppCellParenchymal-10x5prime-Endothelial-Endothelia_lymphatic-Endothelia_Lymphatic|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

ITGA9 SCN3A IPO11 SCN9A

1.37e-05199334a9c2041e54899cb8ccc026758647f3ae3ca457dd
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Upper_Layer|World / Primary Cells by Cluster

ACTN2 SPTBN1 SCN3A SCN9A

1.40e-05200334db10f76938af553d1a2275bb02ef75dff3c3135b
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Upper_Layer-21|World / Primary Cells by Cluster

ACTN2 SPTBN1 SCN3A SCN9A

1.40e-0520033430a3e4aee12ec1b5acdce90f86c9733c27a7f6fc
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Transitional_Principal-Intercalated_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SYK LOXHD1 SCN3A

1.70e-04146333e887e9de895fd453faa703997ef372cc6410fc49
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Dendritic-conventional_dendritic_cell-DC_c1-CLEC9A|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

CES3 PNMA1 ITGA9

2.11e-0415733319c0599a669803c4db1f174de1ce755e562a50a3
ToppCellfacs-Marrow-T-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGA9 SVOP SCN9A

2.15e-04158333f296ca24fdedc33f1d24b79e7660763114ce7fa3
ToppCellfacs-Marrow-T-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGA9 SVOP SCN9A

2.15e-041583338c7108f2c40d97a317762ba0b8eca76542b2ebaf
ToppCellHippocampus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)|Hippocampus / BrainAtlas - Mouse McCarroll V32

LGI2 HSF4 SCN1A

2.27e-04161333b81b346309f3facbfbebd91cae4c5b33c7bd24ef
ToppCellPND07-Endothelial-Endothelial_lymphatic|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SCN1A SCN3A IPO11

2.27e-04161333133b4fadb499e842c19f573f9cf09ce08c1d4813
ToppCellPND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SCN1A SCN3A IPO11

2.27e-04161333cb177ca10d848d0e25399ab5ebfcde1071fb94c2
ToppCellPND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SCN1A SCN3A IPO11

2.27e-041613339466b8658244116f8d21f2f88fb8c2d184b1bdf2
ToppCell3'-Airway_Nasal-Immune_Lymphocytic-Lymphocytic_B|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SYK SVOP SCN3A

2.31e-0416233308b7f06580d516307516d5475a5dae0fa040f1a4
ToppCell3'-Airway_Nasal-Immune_Lymphocytic-Lymphocytic_B-B_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SYK SVOP SCN3A

2.31e-041623331fda21a303a08aff6f97819cd8766cd18784d8bc
ToppCell3'-Airway_Nasal-Immune_Lymphocytic-Lymphocytic_B-B_cell-B_cells|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SYK SVOP SCN3A

2.31e-04162333fc313fb2c55957faa8c9ca4023b3fce63527c267
ToppCell3'-Airway_Nasal-Immune_Lymphocytic-Lymphocytic_B-B_cell-B_cells-B_cells_L.1.5.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SYK SVOP SCN3A

2.31e-04162333002fac3c5c3030950f9eb9e887d59902586d8452
ToppCellPND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SCN1A SCN3A IPO11

2.31e-0416233396c6e94a10b124a1d25dcd705ec5aaa8609c1089
ToppCellfacs-Liver-Non-hepatocytes-24m-Lymphocytic-B_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYK LOXHD1 SCN4A

2.39e-0416433307d9252b267cb61c6050fbfa5b440aef1349f673
ToppCellfacs-Liver-Non-hepatocytes-24m-Lymphocytic-B_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYK LOXHD1 SCN4A

2.39e-041643337c016236f0cea38195c1373ebbd2c0b2b2ec81ad
ToppCellEndothelial-B-IPF_01|World / lung cells shred on cell class, cell subclass, sample id

LOXHD1 MROH2B SCN3A

2.48e-04166333c286987ea4e511195607c87ec4529c2c2ed2122e
ToppCelldroplet-Trachea-3m-Hematologic-myeloid-granulocyte-granulocyte_l34|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SYK REXO2 SCN8A

2.57e-0416833384977db9d71e59208727885320cc18d80d064380
ToppCell368C-Endothelial_cells-Endothelial-F_(Lymphatics)-|368C / Donor, Lineage, Cell class and subclass (all cells)

ITGA9 IPO11 SCN9A

2.57e-04168333dae37b316ce80dfe4236c4ed7f0d4e7c340fa7b6
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CES3 GLYAT DDC

2.57e-04168333fa0d251693935116adf633d02b7ec4a295100865
ToppCell368C-Endothelial_cells-Endothelial-F_(Lymphatics)|368C / Donor, Lineage, Cell class and subclass (all cells)

ITGA9 IPO11 SCN9A

2.57e-04168333a74c8a9e3299183fba31ce3053ef325b5dbcd104
ToppCellPND01-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SCN1A SCN3A IPO11

2.61e-04169333f077e39e41fffe7672541f5b72b80faaf56c597c
ToppCell3'_v3-Lung-Myeloid_Mac-Intestinal_macrophages|Lung / Manually curated celltypes from each tissue

ITGA9 LGI2 SCN9A

2.61e-04169333241644823e6f949aaf4c671d4579721d7ef6b0e5
ToppCellE18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-PMP-PMP_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NES LGI2 SCN3A

2.61e-041693337cb1b87be66a22fe5731bb1b55bc515920fe3e8b
ToppCellPND01-Endothelial-Endothelial_lymphatic-Lymphatic_EC|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SCN1A SCN3A IPO11

2.66e-0417033335e3945d8a540a3e2cec1b559316265aaad023d1
ToppCellPND01-Endothelial-Endothelial_lymphatic|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SCN1A SCN3A IPO11

2.66e-041703330ea625abaa25bab93b70b7000e8f90d5c0f9a0fb
ToppCellPND01-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SCN1A SCN3A IPO11

2.66e-041703330b5ddc7d452db0a389927a367914f7d257703f7e
ToppCellPND14-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ITGA9 SCN3A IPO11

2.71e-04171333686f95892c3909973c66c9a27159a070a068f175
ToppCellPND14-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ITGA9 SCN3A IPO11

2.71e-04171333f7ba03e7bdb687f93782c936c7b3374cc5b3b77c
ToppCellPND14-Endothelial-Endothelial_lymphatic|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ITGA9 SCN3A IPO11

2.71e-04171333d0ac50071a3854d02113c455fcc940a6ec59bbb9
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CES3 GLYAT DDC

2.71e-04171333f5014e3c387fe3118944af392abe10d6b9b0abab
ToppCellPND14-Endothelial-Endothelial_lymphatic-Lymphatic_EC|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ITGA9 SCN3A IPO11

2.71e-04171333fbf8e9db00573adcada4b25730e191417b7c9999
ToppCell356C-Myeloid-Dendritic-cDC_proliferating_2|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

ITGA9 TEDC2 IPO11

2.71e-04171333b113fbebb89056af0b9c775d2fb6552206a80467
ToppCellGlobus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

LGI2 HSF4 SCN1A

2.80e-041733337e3897868dd3f6e4974f593c60649a543ffc8693
ToppCellEndothelial-B-Donor_03|World / lung cells shred on cell class, cell subclass, sample id

ITGA9 SCN3A IPO11

2.80e-04173333a81992965137195d20fc498f750975303961a828
ToppCell5'-Adult-LargeIntestine-Epithelial-neuro-epithelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SVOP DDC SCN3A

2.85e-041743339f114e61458659005b6d0b4aa30a7a059e7aa5c6
ToppCellPCW_05-06-Epithelial-Epithelial_neuroendo-epi_neuroendocrine1[NE1]_(11)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

HSF4 DDC SCN3A

2.90e-041753339941c35601134d88d1b3249c81f8b43a8fc61610
ToppCell10x_3'_v2v3-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia/MHC-B|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

NES SCN1A SPTBN1

2.90e-04175333e99e145a152f534b75267ec492a252a0b814b4f8
ToppCell3'_v3-lymph-node_spleen-Hematopoietic_progenitors-HSC-MPP|lymph-node_spleen / Manually curated celltypes from each tissue

ITGA9 TEDC2 SCN9A

2.95e-0417633332ed5623b8809b9f1aaf7a42dff9807d9376e9c2
ToppCellnormal_Pleural_Fluid-Myeloid_cells-CD163+CD14+_DCs|normal_Pleural_Fluid / Location, Cell class and cell subclass

PNMA5 WDFY3 WWP2

2.95e-041763337a74217b7fa1032b918f00a3972dff5fab74671a
ToppCellwk_15-18-Mesenchymal-Chondrocyte-ASPN+_chondrocyte|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

ACTN2 WDFY3 WWP2

3.04e-04178333a55130670aa95a87b833dd3cd2de461d779e4c06
ToppCellPCW_13-14-Neuronal-Neuronal_postreplicative-neuro_neuronal_(6)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

SVOP SCN1A SCN3A

3.09e-04179333af0b54c9ea0b6e4210f22dbb6e88ecd3276a5f86
ToppCellLPS-IL1RA-Endothelial-Endothelial-Alv_Cap|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NES SPTBN1 SCN9A

3.15e-04180333544fb373a3346186ec60afe2cfcf141bb04a1eed
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

GLYAT DDC SCN9A

3.15e-041803331363b3254470f6ff98630d1df83a1bdbacc137e0
ToppCell3'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating-Lymphatic_EC_differentiating_L.2.5.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ITGA9 SCN3A SCN9A

3.20e-04181333e898ecb8d8f2eb2204225b7b0d665cadcd241139
ToppCell5'-GW_trimst-2-LargeIntestine-Epithelial-neuro-epithelial-EC_cells_(NPW+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SVOP DDC SCN3A

3.20e-041813332392af8c7f040c23a7d416c2e37419954970c8f4
ToppCell367C-Endothelial_cells-Endothelial-F_(Lymphatics)-|367C / Donor, Lineage, Cell class and subclass (all cells)

ITGA9 SCN3A IPO11

3.20e-04181333b244ecaa442bbef51289d8ec574ef08fa9e96318
ToppCell3'-GW_trimst-1.5-SmallIntestine-Endothelial-blood_vessel_EC-cycling_EC|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NES LOXHD1 SPTBN1

3.20e-041813334a225d9a6d113396c6b1d0a839bb4ca9c339a260
ToppCell367C-Endothelial_cells-Endothelial-F_(Lymphatics)|367C / Donor, Lineage, Cell class and subclass (all cells)

ITGA9 SCN3A IPO11

3.20e-04181333dd79de8098edb385a0f85d0e9621503cdf76ec43
ToppCellEpithelial-lung_neuroendocrine_cell_(PNEC)|World / Lineage, Cell type, age group and donor

DDC SCN3A SCN8A

3.25e-0418233357bf4ffb304324e2e392e196336a530d9f78fe0d
ToppCellB_cells-Naive_B_cells_|World / Immune cells in Kidney/Urine in Lupus Nephritis

SYK SCN3A SCN4A

3.25e-0418233363c3b63315276b66667d49fab09661ac320e7a36
ToppCellB_cell_maturation-immature_B_cell|World / Lineage and Cell class

SYK REXO2 SPTBN1

3.25e-041823332c7c51ebc4125d8a33454ffee0b143579ce5e451
ToppCellGlobus_pallidus-Neuronal-Inhibitory|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

LGI2 HSF4 SCN1A

3.25e-0418233304ccfa951eaa31fed6d140edb6c702d49363c5fa
ToppCell(6)_Endothelial-F_(Lymphatics)|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

ITGA9 SCN3A IPO11

3.35e-0418433303ea613e00b45c81b752c14505a0538d698f551e
ToppCellPBMC-Mild-cDC_9|Mild / Compartment, Disease Groups and Clusters

CES3 TEDC2 SCN8A

3.35e-041843332e0c9a2c40c892a2d435eafb31f1f838de9baf15
ToppCellChildren_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

SYK LGI2 SCN9A

3.41e-041853338207f9eff113eed429e961748c6b17d672a13b33
ToppCellPND07-28-samps-Mesenchymal-Myofibroblast-myofibroblast_-_mature_-_C|PND07-28-samps / Age Group, Lineage, Cell class and subclass

NES ITGA9 DDC

3.41e-04185333427176ad9ab8d9511200fb0a132cfd1e835fe35c
ToppCellAdult-Immune-interstitial_macrophage_(C1Q_positive)-D175|Adult / Lineage, Cell type, age group and donor

WDFY3 ITGA9 LGI2

3.41e-04185333ab5704b96f1d368911308797d10c7c52766ab134
ToppCellEndoth-Lymph|World / shred by cell class for parenchyma

ITGA9 SCN3A IPO11

3.41e-0418533397a6c4cd00684d4085d36ef32f7dbb99563ed357
ToppCell343B-Endothelial_cells-Endothelial-F_(Lymphatics)|343B / Donor, Lineage, Cell class and subclass (all cells)

ITGA9 SCN3A IPO11

3.46e-041863337a8da2ad140bea3207bd868212cc5e201d586772
ToppCell343B-Endothelial_cells-Endothelial-F_(Lymphatics)-|343B / Donor, Lineage, Cell class and subclass (all cells)

ITGA9 SCN3A IPO11

3.46e-04186333dc394034929c6b10ae0e1c1a028cc3d4ce873298
ToppCellAnterior_Cingulate_gyrus_(CgG)|World / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PNMA5 STAG3L3 SCN9A

3.46e-0418633332af3f211f9ad5d5c6b86b83325cfbf2f8466b56
ToppCell356C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)-|356C / Donor, Lineage, Cell class and subclass (all cells)

NES LOXHD1 SPTBN1

3.46e-04186333f0b78c7ee20279970ea8961bf59acb5262f2dce5
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SVOP SCN1A SCN8A

3.46e-041863337278a1a1bf9bb27aeb03852134defb31b62f30d6
ToppCellFetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

DDC SCN3A SCN8A

3.46e-04186333b45cce768e4bf91da194fd9660cab7520dfb15ac
ToppCell356C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)|356C / Donor, Lineage, Cell class and subclass (all cells)

NES LOXHD1 SPTBN1

3.46e-041863332b3c814a7dee8286ea113c63dc3de5daf0257d37
ToppCellfacs-SCAT-Fat-24m-Endothelial-nan|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NES REXO2 SPTBN1

3.52e-0418733351336037dfd4bbe9fe9ce1e5b6b92d037156690c
ToppCellfacs-SCAT-Fat-24m-Endothelial-endothelial_cell|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NES REXO2 SPTBN1

3.52e-0418733343e35ec995afd8780893de42ac4ee466794991d7
ToppCellPCW_10-12-Epithelial-Epithelial_neuroendo-epi_neuroendocrine1[NE1]_(11)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

SVOP DDC SCN3A

3.52e-0418733398477ba04a42a8da80a72f41a182429f46283595
ToppCell3'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LOXHD1 MROH2B SPTBN1

3.52e-0418733325efb82afe863a853ecdd781ad89026c993aaa67
ToppCellCerebellum-Neuronal|Cerebellum / BrainAtlas - Mouse McCarroll V32

LGI2 SVOP SCN1A

3.52e-0418733361b9d6eb131a674598aa8409d7fa909c8765442d
ToppCellB_cell_maturation-immature_B_cell|B_cell_maturation / Lineage and Cell class

SYK REXO2 SPTBN1

3.52e-041873339afbb21654c8eb6f9c6a7cbd0664d890282ddceb
ToppCellfacs-SCAT-Fat-24m-Endothelial|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NES REXO2 SPTBN1

3.52e-041873338ca9481d661626f6f0e1b61eb142b051192a9208
ToppCelldroplet-Fat-SCAT-30m-Endothelial-Cd36+|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NES SPTBN1 SCN3A

3.57e-04188333e901a9bdf00b8e91806f445af66647373bf62661
ToppCell3'-Broncho-tracheal-Epithelial-Neuro-endocrine/ionocytic|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DDC SCN3A SCN9A

3.57e-041883331f912ea015f50570e848259d948a0ba682d64bb4
DrugN-(2-methyl-3-(4-(4-(4-(trifluoromethoxy)benzyloxy)piperidin-1-yl)-1,3,5-triazin-2-ylamino)phenyl)acetamide

SCN3A SCN4A SCN9A

2.77e-093333ctd:C561228
DrugZonisamide

SCN1A SCN3A SCN4A SCN9A

8.59e-0917334DB00909
DrugAPETx1, Anthopleura elegantissima

SCN3A SCN4A SCN8A

5.53e-086333ctd:C475726
DrugScorpion Venoms

SCN3A SCN4A SCN9A

2.23e-0618333ctd:D012604
Drugdiprafenone

SCN3A SCN4A SCN9A

2.65e-0619333CID000071249
DrugAC1NT1AF

SCN3A SCN4A SCN9A

6.24e-0625333CID005322157
DrugPirmenolum

SCN3A SCN4A SCN9A

7.05e-0626333CID000004853
DrugPbTx-1

SCN3A SCN4A SCN9A

7.92e-0627333CID006437089
DrugAC1L1MOZ

SCN3A SCN4A SCN9A

7.92e-0627333CID000031958
Drugnefopam

SCN3A SCN4A SCN9A

7.92e-0627333CID000004450
Drugparaben

SCN3A SCN4A SCN9A

8.87e-0628333CID000007175
Drugtocainide

SCN3A SCN4A SCN9A

1.10e-0530333CID000038945
Drugoxcarbazepine

REXO2 SCN4A SCN9A

1.10e-0530333CID000034312
DrugNSC93767

SCN3A SCN4A SCN9A

1.34e-0532333CID000005658
Drug5-hydroxypropafenone

SCN3A SCN4A SCN9A

1.61e-0534333CID000107927
Drugciguatoxin

HSF4 SCN4A SCN9A

1.76e-0535333CID005311333
Drugbenzocaine

SCN3A SCN4A SCN9A

2.08e-0537333CID000002337
Drugaprindine

SCN3A SCN4A SCN9A

2.26e-0538333CID000002218
DrugTetrodotoxin

SCN3A SCN8A SCN9A

2.64e-0540333ctd:D013779
DrugS-ropivacaine

SCN3A SCN4A SCN9A

2.64e-0540333CID000071273
Drugpilsicainide

SCN3A SCN4A SCN9A

4.04e-0546333CID000004820
Drugspiradoline

SCN3A SCN4A SCN9A

4.04e-0546333CID000005620
Drugnorepinephrine sulfate

NES DDC

4.26e-057332CID000123747
Drugindoxacarb

SCN3A SCN4A SCN9A

4.88e-0549333CID000107720
Drug2,3,5,6-tetrafluoro-4-methylbenzyl (Z)-(1RS)-cis-3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylate

SCN3A SCN8A

5.67e-058332ctd:C489827
Drugdecamethrin

DDC SCN1A SCN3A SCN8A

5.75e-05146334ctd:C017180
Drugsalbutamol

DDC SCN3A SCN4A SCN9A

5.75e-05146334CID000002083
DrugAC1NSN3X

SCN3A SCN4A SCN9A

6.54e-0554333CID005366189
Drugorphenadrine

PNMA1 SCN4A SCN9A

7.30e-0556333CID000004601
Drugtriamterene

SCN3A SCN4A SCN9A

8.11e-0558333CID000005546
Drugmethylglucamine

SCN4A SCN8A SCN9A

9.90e-0562333CID000004049
Drugzonisamide

SCN3A SCN4A SCN9A

9.90e-0562333CID000005734
DrugRH-3421

SCN4A SCN9A

1.11e-0411332CID000108039
Drugchloroacetylajmaline

SCN4A SCN9A

1.11e-0411332CID000038681
Drugsaxitoxin

SCN3A SCN4A SCN9A

1.14e-0465333CID000037165
DrugAC1L1CQC

SCN3A SCN4A SCN9A

1.14e-0465333CID000002012
Drugresiniferatoxin

SCN3A SCN4A SCN9A

1.19e-0466333CID000104826
Drugmexiletine

SCN3A SCN4A SCN9A

1.19e-0466333CID000004178
Drugdisopyramide

SCN3A SCN4A SCN9A

1.19e-0466333CID000003114
Drugdibucaine

SCN3A SCN4A SCN9A

1.30e-0468333CID000003025
Drugstrychnine HCl

REXO2 SCN3A SCN4A SCN9A

1.32e-04181334CID000005304
DrugRo 22-9194

SCN4A SCN9A

1.33e-0412332CID000129209
DrugGBR 12909

SCN3A SCN4A SCN9A

1.36e-0469333CID000003455
DrugT2755

SCN3A SCN4A SCN9A

1.48e-0471333CID000005514
Drugsynthetic pyrethrins

REXO2 SCN4A SCN9A

1.48e-0471333CID000002982
Drugflecainide

SCN3A SCN4A SCN9A

1.48e-0471333CID000003355
Drugofloxacin

GLYAT HSF4 SPTBN1

1.55e-0472333CID000004583
DrugCID6432355

SCN4A SCN9A

1.57e-0413332CID006432355
Drugcefditoren

HSF4 SPTBN1

1.57e-0413332CID000444006
DrugAC1LCJM3

SCN4A SCN9A

1.57e-0413332CID000631640
Drugprocainamide

WDFY3 SCN3A SCN4A SCN9A

1.59e-04190334CID000004913
DrugFlutamide [13311-84-7]; Down 200; 14.4uM; PC3; HT_HG-U133A

SYK CES3 GLYAT SPTBN1

1.62e-041913343803_DN
DrugVitamin K2 [11032-49-8]; Up 200; 9uM; MCF7; HT_HG-U133A

ITGA9 HSF4 SPTBN1 SCN4A

1.66e-041923344356_UP
Drug1, 3-diallylurea

SCN3A SCN4A SCN9A

1.68e-0474333CID000074537
Drugimide

SCN3A SCN4A SCN9A

1.68e-0474333CID000443040
Drugisofagomine

ITGA9 SCN4A SCN9A

1.74e-0475333CID000447607
Drugdiphenhydramine

SCN3A SCN4A SCN9A

1.74e-0475333CID000003100
Drugmonastrol; Up 200; 100uM; MCF7; HG-U133A

TUT1 ATG13 TEDC2 SPTBN1

1.76e-04195334311_UP
DrugN-Acetyl-DL-homocysteine Thiolactone [1195-16-0]; Down 200; 25.2uM; PC3; HT_HG-U133A

SYK WDFY3 ZNF227 SPTBN1

1.76e-041953343755_DN
DrugLidocaone hydrochloride [73-78-9]; Up 200; 14.8uM; MCF7; HT_HG-U133A

GLYAT HSF4 SPTBN1 SCN8A

1.79e-041963344421_UP
DrugTetracycline hydrochloride [64-75-5]; Down 200; 8.4uM; PC3; HT_HG-U133A

CES3 WDFY3 TEDC2 SCN9A

1.79e-041963345757_DN
DrugNaltrexone hydrochloride dihydrate [16676-29-2]; Down 200; 9.6uM; PC3; HT_HG-U133A

TUT1 WDFY3 TEDC2 SPTBN1

1.79e-041963345765_DN
DrugBuspirone hydrochloride [33386-08-2]; Down 200; 9.4uM; MCF7; HT_HG-U133A

NES ZNF227 TEDC2 SPTBN1

1.83e-041973345343_DN
Druglorcainide

SCN4A SCN9A

1.83e-0414332CID000042883
Drugoctylguanidine

SCN4A SCN9A

1.83e-0414332CID000030621
DrugAG-028671 [847803-03-6]; Down 200; 10uM; PC3; HT_HG-U133A

ARPIN WDFY3 ATG13 SPTBN1

1.86e-041983346557_DN
DrugST021200; Down 200; 10uM; MCF7; HT_HG-U133A

GLYAT ARPIN ZNF227 TEDC2

1.86e-041983347488_DN
DrugCefoperazone dihydrate; Up 200; 5.8uM; PC3; HT_HG-U133A

ZNF227 TEDC2 SPTBN1 SCN8A

1.86e-041983346323_UP
DrugSuprofen [40828-46-4]; Up 200; 15.4uM; MCF7; HT_HG-U133A

SYK CES3 ARPIN ACTN2

1.86e-041983343343_UP
DrugTolbutamide [64-77-7]; Up 200; 14.8uM; MCF7; HT_HG-U133A

TUT1 ACTN2 SCN1A SPTBN1

1.90e-041993344362_UP
DrugAminophylline [317-34-0]; Up 200; 9.6uM; PC3; HT_HG-U133A

ACTN2 ZNF227 TEDC2 SPTBN1

1.90e-041993346295_UP
DrugDoxylamine succinate [562-10-7]; Up 200; 10.2uM; MCF7; HT_HG-U133A

CES3 GLYAT ACTN2 WDFY3

1.90e-041993344819_UP
DrugArecoline hydrobromide [300-08-3]; Up 200; 17uM; MCF7; HT_HG-U133A

ARPIN WDFY3 SPTBN1 SCN8A

1.90e-041993345423_UP
DrugICI182,780; Down 200; 1uM; PC3; HT_HG-U133A

CES3 ARPIN WDFY3 SPTBN1

1.94e-042003345931_DN
Drugtrimethyloxonium

SCN4A SCN9A

2.11e-0415332CID000093245
DrugAC1L1W4O

SCN4A SCN9A

2.11e-0415332CID000036625
Drugbupropion

SCN3A SCN4A SCN9A

2.19e-0481333CID000000444
DrugSodium

SCN3A SCN8A SCN9A

2.44e-0484333ctd:D012964
Drugarticaine

SCN4A SCN9A

2.73e-0417332CID000032169
Druglifarizine

SCN4A SCN9A

2.73e-0417332CID000071336
DrugS 254

GLYAT DDC

2.73e-0417332CID000029642
Drugphenytoin

LGI2 SCN3A SCN4A SCN9A

2.74e-04219334CID000001775
Drugpentobarbital

REXO2 SCN3A SCN4A SCN9A

2.98e-04224334CID000004737
Drugmoricizine

SCN4A SCN9A

3.07e-0418332CID000034632
Drugpropafenone

SCN3A SCN4A SCN9A

3.84e-0498333CID000004932
Drugtrimethoprim

SCN3A SCN4A SCN9A

3.96e-0499333CID000005578
Drugisradipine

SCN3A SCN4A SCN9A

4.08e-04100333CID000003784
Drugciprofloxacin

GLYAT HSF4 SPTBN1

4.20e-04101333CID000002764
DrugBDF 9148

SCN4A SCN9A

4.20e-0421332CID000123765
Druggrepafloxacin

GLYAT SPTBN1

5.06e-0423332CID000072474
DrugMulticide

SCN4A SCN9A

5.99e-0425332CID000024365
Drugbatrachotoxinin A 20-alpha-benzoate

SCN4A SCN9A

5.99e-0425332CID005485225
Druglamotrigine

SCN3A SCN4A SCN9A

6.29e-04116333CID000003878
DrugPbTx-2

SCN4A SCN9A

6.48e-0426332CID000002432
Drugphenamil

SCN4A SCN9A

6.48e-0426332CID000004755
Drugethionamide

GLYAT SCN9A

6.48e-0426332CID002761171
Diseasegeneralized epilepsy with febrile seizures plus 2 (implicated_via_orthology)

SCN1A SCN3A SCN4A SCN8A SCN9A

2.71e-1310325DOID:0111294 (implicated_via_orthology)
DiseaseDravet syndrome (implicated_via_orthology)

SCN1A SCN3A SCN4A SCN8A SCN9A

2.71e-1310325DOID:0080422 (implicated_via_orthology)
Diseasegeneralized epilepsy with febrile seizures plus (implicated_via_orthology)

SCN1A SCN3A SCN4A SCN8A SCN9A

8.51e-1312325DOID:0060170 (implicated_via_orthology)
Diseaseepilepsy (implicated_via_orthology)

SCN1A SCN3A SCN4A SCN8A SCN9A

8.63e-07163325DOID:1826 (implicated_via_orthology)
DiseaseEarly Infantile Epileptic Encephalopathy 6

SCN1A SCN9A

1.14e-062322C4551549
Diseaseanxiety disorder (implicated_via_orthology)

SCN1A SCN3A SCN9A

1.76e-0622323DOID:2030 (implicated_via_orthology)
DiseaseB Virus Infection

SCN8A SCN9A

3.42e-063322C0037140
DiseasePostherpetic neuralgia

SCN8A SCN9A

3.42e-063322C0032768
DiseaseHerpesviridae Infections

SCN8A SCN9A

3.42e-063322C0019372
DiseaseEarly Childhood Epilepsy, Myoclonic

SCN1A SCN9A

3.18e-058322C0393695
DiseaseIdiopathic Myoclonic Epilepsy

SCN1A SCN9A

3.18e-058322C0338478
DiseaseSymptomatic Myoclonic Epilepsy

SCN1A SCN9A

3.18e-058322C0338479
DiseaseMyoclonic Encephalopathy

SCN1A SCN9A

3.18e-058322C0438414
DiseaseBenign Infantile Myoclonic Epilepsy

SCN1A SCN9A

3.18e-058322C0751120
DiseaseMyoclonic Absence Epilepsy

SCN1A SCN9A

3.18e-058322C0393703
DiseaseMyoclonic Epilepsy

SCN1A SCN9A

4.08e-059322C0014550
DiseaseGeneralized Epilepsy with Febrile Seizures Plus

SCN1A SCN9A

4.08e-059322C3502809
DiseaseEpilepsy, Myoclonic, Infantile

SCN1A SCN9A

5.10e-0510322C0917800
DiseaseMyoclonic Astatic Epilepsy

SCN1A SCN9A

6.23e-0511322C0393702
DiseaseInfantile Severe Myoclonic Epilepsy

SCN1A SCN9A

8.82e-0513322C0751122
DiseaseNeurodevelopmental Disorders

WDFY3 SCN1A SCN8A

1.41e-0493323C1535926
DiseaseMAJOR AFFECTIVE DISORDER 2

ITGA9 DDC

1.53e-0417322C1839839
DiseaseEpilepsy

SCN1A SCN8A SCN9A

2.25e-04109323C0014544

Protein segments in the cluster

PeptideGeneStartEntry
GDSMELEIWCLEMNE

ATG13

91

O75143
WMEGAMEDLQDMFIV

ACTN2

531

P35609
CMCEAWEEILMQMDS

ANAPC4

271

Q9UJX5
WMPESEMEVMELELG

ARPIN

141

Q7Z6K5
CTELETVMMDWLGKM

DDC

111

P20711
ATEEEMWECLNALGM

MAGEB17

216

A8MXT2
IGICEAESWMLVMEM

SYK

436

P43405
AESWMLVMEMAELGP

SYK

441

P43405
MDQLLGNMIEMWVDR

IPO11

821

Q9UI26
GNMIEMWVDRMDNIT

IPO11

826

Q9UI26
PVCWDLMDQTGEMRM

GLYAT

216

Q6IB77
MCAVIDEEEMMEWTS

LOXHD1

1666

Q8IVV2
MEGCMGEESFQMWEL

NES

1

P48681
GESMAQRMVWVDLEM

REXO2

36

Q9Y3B8
MWQKEEMGISCELLE

ITGA9

686

Q13797
EWTLMDLDMELSLMQ

HSF4

406

Q9ULV5
WGLLDTMEQMSREDM

CES3

356

Q6UWW8
MAMTLLEDWCRGMDV

PNMA1

1

Q8ND90
MELLQDMSGIMKWSE

TRIM34

246

Q9BYJ4
GLAWMADAMEMMILS

SVOP

91

Q8N4V2
MWDCMEVAGQAMCLT

SCN4A

766

P35499
MREELSAAPMDWMQE

TEDC2

281

Q7L2K0
MENCMVLEWDHIEMN

LGI2

251

Q8N0V4
TMWDCMEVAGQAMCL

SCN9A

931

Q15858
ETMWDCMEVAGQTMC

SCN3A

946

Q9NY46
MMWDNVNAEDCQEMF

MROH2B

876

Q7Z745
MWDCMEVAGQAMCLT

SCN1A

956

P35498
MDWMDEMKVLVLSQD

SPTBN1

541

Q01082
MALTLLEDWCKGMDM

PNMA5

1

Q96PV4
ELMLCGMQEIDMSDW

WWP2

746

O00308
LDKWMLEMTEGPCRM

WDFY3

2366

Q8IZQ1
EMVIEVGEMVQDWAM

TUT1

691

Q9H6E5
MWDCMEVAGQAMCLI

SCN8A

941

Q9UQD0
MVSQLEAEEKLWMME

ZNF227

71

Q86WZ6
GCFKDWMVSMIMDRE

STAG3L3

86

P0CL85