Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
HumanPheno	Hyperopic astigmatism	CHST6 ROBO3	3.46e-05	5	10	2	HP:0000484
Domain	Carb-bd-like_fold	CILP2 EPM2A	1.18e-04	8	39	2	IPR013784
Domain	Oxysterol_BP	OSBPL3 OSBPL5	2.77e-04	12	39	2	PF01237
Domain	Oxysterol-bd	OSBPL3 OSBPL5	2.77e-04	12	39	2	IPR000648
Domain	Oxysterol-bd_CS	OSBPL3 OSBPL5	2.77e-04	12	39	2	IPR018494
Domain	OSBP	OSBPL3 OSBPL5	2.77e-04	12	39	2	PS01013
Domain	TSP_1	ADGRB3 CILP2 SSPOP	3.07e-04	63	39	3	PF00090
Domain	TSP1	ADGRB3 CILP2 SSPOP	3.36e-04	65	39	3	SM00209
Domain	TSP1_rpt	ADGRB3 CILP2 SSPOP	3.36e-04	65	39	3	IPR000884
Domain	TSP1	ADGRB3 CILP2 SSPOP	3.36e-04	65	39	3	PS50092
Domain	Keratin_B2_2	KRTAP16-1 KRTAP10-7	3.00e-03	39	39	2	PF13885
Domain	LDLR_class-A_CS	LRP3 SSPOP	3.15e-03	40	39	2	IPR023415
Domain	Kinesin_motor_CS	KIF24 KIFC2	3.31e-03	41	39	2	IPR019821
Domain	Kinesin-like_fam	KIF24 KIFC2	3.63e-03	43	39	2	IPR027640
Domain	KINESIN_MOTOR_1	KIF24 KIFC2	3.80e-03	44	39	2	PS00411
Domain	-	KIF24 KIFC2	3.80e-03	44	39	2	3.40.850.10
Domain	Kinesin_motor_dom	KIF24 KIFC2	3.80e-03	44	39	2	IPR001752
Domain	Kinesin	KIF24 KIFC2	3.80e-03	44	39	2	PF00225
Domain	KISc	KIF24 KIFC2	3.80e-03	44	39	2	SM00129
Domain	KINESIN_MOTOR_2	KIF24 KIFC2	3.80e-03	44	39	2	PS50067
Domain	Ldl_recept_a	LRP3 SSPOP	3.97e-03	45	39	2	PF00057
Domain	-	LRP3 SSPOP	4.15e-03	46	39	2	4.10.400.10
Domain	LDLRA_1	LRP3 SSPOP	4.51e-03	48	39	2	PS01209
Domain	LDrepeatLR_classA_rpt	LRP3 SSPOP	4.70e-03	49	39	2	IPR002172
Domain	LDLa	LRP3 SSPOP	4.70e-03	49	39	2	SM00192
Domain	LDLRA_2	LRP3 SSPOP	4.70e-03	49	39	2	PS50068
Domain	CUB	ADGRB3 LRP3	5.47e-03	53	39	2	PS01180
Domain	AGC-kinase_C	CDC42BPG MAST4	6.09e-03	56	39	2	IPR000961
Domain	AGC_KINASE_CTER	CDC42BPG MAST4	6.09e-03	56	39	2	PS51285
Domain	S_TK_X	CDC42BPG MAST4	6.09e-03	56	39	2	SM00133
Domain	CUB_dom	ADGRB3 LRP3	6.31e-03	57	39	2	IPR000859
Domain	KAP	KRTAP16-1 KRTAP10-7	6.52e-03	58	39	2	IPR002494
Domain	FN3	ROBO3 IL4R EPHA8	6.73e-03	185	39	3	SM00060
Domain	FN3	ROBO3 IL4R EPHA8	8.21e-03	199	39	3	PS50853
Domain	SAM_1	KIF24 EPHA8	8.87e-03	68	39	2	PF00536
Domain	FN3_dom	ROBO3 IL4R EPHA8	9.39e-03	209	39	3	IPR003961
Domain	-	SSPOP EPHA8	1.02e-02	73	39	2	2.60.120.260
Pubmed	Oxysterol binding protein induces upregulation of SREBP-1c and enhances hepatic lipogenesis.	OSBPL3 OSBPL5	4.06e-06	3	41	2	17303778
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	LRP3 ZNF579 SNX11 PER2 IL4R KIFC2 ANKRD9 ZBTB4 OSBPL5	4.48e-06	1105	41	9	35748872
Pubmed	Family of human oxysterol binding protein (OSBP) homologues. A novel member implicated in brain sterol metabolism.	OSBPL3 OSBPL5	2.03e-05	6	41	2	10588946
Pubmed	The mammalian oxysterol-binding protein-related proteins (ORPs) bind 25-hydroxycholesterol in an evolutionarily conserved pocket.	OSBPL3 OSBPL5	3.78e-05	8	41	2	17428193
Pubmed	Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.	PCDHA12 CCR10 KIFC2 CHAF1A OSBPL5	4.16e-05	329	41	5	17474147
Pubmed	The OSBP-related protein family in humans.	OSBPL3 OSBPL5	7.41e-05	11	41	2	11483621
Pubmed	A family of 12 human genes containing oxysterol-binding domains.	OSBPL3 OSBPL5	8.88e-05	12	41	2	11735225
Pubmed	An oxysterol-binding protein family identified in the mouse.	OSBPL3 OSBPL5	8.88e-05	12	41	2	12215260
Pubmed	O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.	ADGRB3 CILP2 SSPOP	9.68e-05	75	41	3	20637190
Pubmed	SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins.	FBXO5 PER2	1.22e-04	14	41	2	17463251
Pubmed	Genome-wide association analysis of genetic generalized epilepsies implicates susceptibility loci at 1q43, 2p16.1, 2q22.3 and 17q21.32.	SNX11 MAST4	1.82e-04	17	41	2	22949513
Pubmed	Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	ZBTB4 EPHA8 OSBPL5	2.48e-04	103	41	3	10819331
Pubmed	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	MAST4 PER2 ZMYM3	2.55e-04	104	41	3	9205841
Pubmed	Requirements for Neurogenin2 during mouse postnatal retinal neurogenesis.	ROBO3 RP1L1	5.39e-04	29	41	2	30048641
Pubmed	DNA Damage Regulates Translation through β-TRCP Targeting of CReP.	FBXO5 PER2	7.87e-04	35	41	2	26091241
Cytoband	Ensembl 112 genes in cytogenetic band chr17q21	CCR10 SNX11 KRTAP16-1 KRT35	8.33e-04	473	41	4	chr17q21
Cytoband	17q21.2	KRTAP16-1 KRT35	1.81e-03	70	41	2	17q21.2
GeneFamily	Oxysterol binding proteins\|Pleckstrin homology domain containing	OSBPL3 OSBPL5	1.86e-04	12	31	2	670
GeneFamily	Kinesins\|Pleckstrin homology domain containing	KIF24 KIFC2	2.81e-03	46	31	2	622
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	CDC42BPG OSBPL3 OSBPL5	5.18e-03	206	31	3	682
GeneFamily	Sterile alpha motif domain containing	KIF24 EPHA8	9.94e-03	88	31	2	760
Disease	C-reactive protein measurement	KCNK3 CABP1 CILP2 SNX11 SSPOP IL4R RP1L1	7.77e-04	1206	38	7	EFO_0004458
Disease	interleukin 17 measurement	EPM2A EPHA8	1.54e-03	45	38	2	EFO_0008174
Disease	systolic blood pressure, alcohol consumption measurement	KCNK3 RP1L1	1.68e-03	47	38	2	EFO_0006335, EFO_0007878
Disease	mean arterial pressure, alcohol consumption measurement	KCNK3 RP1L1	2.06e-03	52	38	2	EFO_0006340, EFO_0007878
Disease	mean arterial pressure, alcohol drinking	KCNK3 RP1L1	7.10e-03	98	38	2	EFO_0004329, EFO_0006340
Disease	uric acid measurement	CDC42BPG ZMYM3 SIMC1 ZBTB4	7.65e-03	610	38	4	EFO_0004761
Disease	pulse pressure measurement	KCNK3 PCDHA12 CILP2 SNX11 ROBO3 SSPOP	8.24e-03	1392	38	6	EFO_0005763

Protein segments in the cluster

Peptide	Gene	Start	Entry
RASRAFCPRPCALPG	EPM2A	186	B3EWF7
PRRGCPRRPRLSSCS	CCR10	336	P46092
CGRGQRTRTRSCTPP	ADGRB3	361	O60242
PRSPCSARLPCRLFF	DLL3	46	Q9NYJ7
CRPRSAPSRCGPGLR	DLL3	191	Q9NYJ7
ECSPRSCPELTSGPR	CHAF1A	201	Q13111
SSGDPSSRRPLCRPA	CABP1	111	Q9NZU7
LRPRSFPSPTKCLRC	CDC42BPG	881	Q6DT37
TPSRRCLCSGAPRSA	KCNK3	356	O14649
SRTSIPRQPCACPAT	PER2	951	O15055
RCLARPSSPLVPSCS	KIF24	1261	Q5T7B8
TFPCSGARSTRCLPV	LRP3	216	O75074
SCGPSAARTNCSPRP	KRT35	431	Q92764
CPRPRGATAPCSSDR	FOXD4	341	Q12950
CCCGDRSSPPTTPLR	IL4R	746	P24394
PHLPAFRTRPRCCTS	KLHL18	271	O94889
RPPRCSCSASPSAVT	FBXO5	11	Q9UKT4
ATVSRCPPPAFVRSC	EPHA8	906	P29322
PRRALAPPSAGFRCC	ANKRD9	96	Q96BM1
PRSRSLSPGRSPACC	MAST4	351	O15021
RPACSRPACCGPTST	KRTAP10-7	351	P60409
PRSCSPPRRFEPCSS	KPRP	266	Q5T749
PGSSASAICRPTCPR	KRTAP16-1	361	A8MUX0
SCCRRKYRPEAPGPS	SCNM1	126	Q9BWG6
THRLPCTSRCPRPCR	SCNN1D	606	P51172
DPGCSRSSSRSPCRA	C3orf56	221	Q8N813
RPQRACPSSPGSRPC	KIFC2	811	Q96AC6
RRRTCLPAPCPSSSN	OSBPL3	511	Q9H4L5
LRCSAPPTVSRCAPG	PCDHA12	721	Q9UN75
FLRRRFSLCPPSSTP	OSBPL5	6	Q9H0X9
CCFLPRSGRRSSPSP	SNX11	181	Q9Y5W9
RSRLCPSPGDSSCPG	SSPOP	2801	A2VEC9
PSCPPLCLQGTRSRT	SSPOP	4211	A2VEC9
RCPARRPCSPASAPA	FAM178B	76	Q8IXR5
CPPRASSCPPRALSC	SIMC1	216	Q8NDZ2
PDTRCPSLAGSSPRC	CILP2	416	Q8IUL8
PPRLECLFPSSCGSR	CSNK1G2-AS1	111	Q8NCQ2
SCGSRRATSRPGFPP	CSNK1G2-AS1	121	Q8NCQ2
SRALCSPPACSAFPR	CHST6	126	Q9GZX3
APSGVSRFCPPRKSC	COA8	51	Q96IL0
PPRGRPCPQRRSSSC	RP1L1	856	Q8IWN7
RSPSAQEPRGSCCPS	ROBO3	971	Q96MS0
RAGRRPSTRFTCPHC	ZBTB4	756	Q9P1Z0
RAPLPCPTCGRLFRF	ZNF579	41	Q8NAF0
GPPRPCSFCRRSLSD	ZMYM3	541	Q14202