Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionRNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity

NANOGP8 NANOG

1.28e-044932GO:0001010
GeneOntologyMolecularFunctionubiquitin-protein transferase activity

HECTD4 DZIP3 TRIM31 KLHL42 BIRC2 HERC6 BCOR FBXL5 TRIM7

3.60e-04473939GO:0004842
GeneOntologyMolecularFunctioncalcium ion sensor activity

MICU3 EFHB

4.44e-047932GO:0061891
GeneOntologyMolecularFunctionmetal ion sensor activity

MICU3 EFHB

5.90e-048932GO:0140784
GeneOntologyMolecularFunctionubiquitin-like protein transferase activity

HECTD4 DZIP3 TRIM31 KLHL42 BIRC2 HERC6 BCOR FBXL5 TRIM7

6.37e-04512939GO:0019787
GeneOntologyMolecularFunctionaminoacyltransferase activity

HECTD4 DZIP3 TRIM31 KLHL42 BIRC2 HERC6 BCOR FBXL5 TRIM7

8.36e-04532939GO:0016755
GeneOntologyMolecularFunctionDNA-binding transcription activator activity, RNA polymerase II-specific

HOXB3 NANOGP8 ZBED4 NANOG EHF ELK1 ELK3 TBX1 TLX1

1.20e-03560939GO:0001228
GeneOntologyMolecularFunctionDNA-binding transcription activator activity

HOXB3 NANOGP8 ZBED4 NANOG EHF ELK1 ELK3 TBX1 TLX1

1.29e-03566939GO:0001216
GeneOntologyBiologicalProcessnegative regulation of protein-containing complex assembly

CSNK1A1L CSNK1A1 AVIL CAPZA1 CAPZA2 TRIM31 BIRC2 INPP5J

1.06e-06173928GO:0031333
GeneOntologyBiologicalProcesscranial nerve morphogenesis

HOXA3 HOXB3 DMD TBX1

1.21e-0532924GO:0021602
GeneOntologyBiologicalProcessnegative regulation of NLRP3 inflammasome complex assembly

CSNK1A1L CSNK1A1 TRIM31

7.90e-0519923GO:1900226
GeneOntologyBiologicalProcessnegative regulation of inflammasome-mediated signaling pathway

CSNK1A1L CSNK1A1 TRIM31

1.08e-0421923GO:0141086
GeneOntologyBiologicalProcessglossopharyngeal nerve morphogenesis

HOXA3 HOXB3

1.17e-044922GO:0021615
GeneOntologyBiologicalProcessnegative regulation of endodermal cell fate specification

NANOGP8 NANOG

1.17e-044922GO:0042664
GeneOntologyBiologicalProcessglossopharyngeal nerve development

HOXA3 HOXB3

1.95e-045922GO:0021563
GeneOntologyBiologicalProcessregulation of endodermal cell fate specification

NANOGP8 NANOG

1.95e-045922GO:0042663
GeneOntologyBiologicalProcesscranial nerve development

HOXA3 HOXB3 DMD TBX1

2.29e-0467924GO:0021545
GeneOntologyBiologicalProcessbarbed-end actin filament capping

AVIL CAPZA1 CAPZA2

2.88e-0429923GO:0051016
GeneOntologyBiologicalProcessnegative regulation of endodermal cell differentiation

NANOGP8 NANOG

2.92e-046922GO:1903225
GeneOntologyBiologicalProcessregulation of protein-containing complex assembly

CSNK1A1L ATR CSNK1A1 AVIL CAPZA1 CAPZA2 TRIM31 BIRC2 INPP5J

3.34e-04489929GO:0043254
MousePhenofusion of glossopharyngeal and vagus nerve

HOXA3 HOXB3 TBX1

2.37e-0511753MP:0004568
DomainF_ACTIN_CAPPING_A_1

CAPZA1 CAPZA2

6.72e-053892PS00748
DomainF_ACTIN_CAPPING_A_2

CAPZA1 CAPZA2

6.72e-053892PS00749
DomainF-actin_cap_A

CAPZA1 CAPZA2

6.72e-053892PF01267
DomainCapZ_alpha

CAPZA1 CAPZA2

6.72e-053892IPR002189
DomainDUF4074

HOXA3 HOXB3

6.72e-053892IPR025281
DomainF-actin_cap_asu_CS

CAPZA1 CAPZA2

6.72e-053892IPR017865
DomainDUF4074

HOXA3 HOXB3

6.72e-053892PF13293
DomainHomeobox

HOXA3 HOXB3 NANOGP8 ZEB1 NANOG TLX3 TLX1

1.28e-04234897PF00046
DomainZnf_B-box_chordata

TRIM31 TRIM7

1.34e-044892IPR020457
DomainHOMEOBOX_1

HOXA3 HOXB3 NANOGP8 ZEB1 NANOG TLX3 TLX1

1.35e-04236897PS00027
DomainHOX

HOXA3 HOXB3 NANOGP8 ZEB1 NANOG TLX3 TLX1

1.38e-04237897SM00389
DomainHOMEOBOX_2

HOXA3 HOXB3 NANOGP8 ZEB1 NANOG TLX3 TLX1

1.45e-04239897PS50071
DomainHomeobox_dom

HOXA3 HOXB3 NANOGP8 ZEB1 NANOG TLX3 TLX1

1.45e-04239897IPR001356
DomainETS_DOMAIN_1

EHF ELK1 ELK3

3.14e-0428893PS00345
DomainETS_DOMAIN_2

EHF ELK1 ELK3

3.14e-0428893PS00346
DomainETS

EHF ELK1 ELK3

3.14e-0428893SM00413
DomainEts_dom

EHF ELK1 ELK3

3.14e-0428893IPR000418
DomainETS_DOMAIN_3

EHF ELK1 ELK3

3.14e-0428893PS50061
DomainEts

EHF ELK1 ELK3

3.14e-0428893PF00178
DomainHomeobox_metazoa

HOXA3 HOXB3 TLX3 TLX1

9.01e-0490894IPR020479
DomainHomeodomain-like

HOXA3 HOXB3 NANOGP8 ZEB1 NANOG TLX3 TLX1

1.04e-03332897IPR009057
DomainEF_Hand_1_Ca_BS

MICU3 ITSN2 PPEF2 EFHB DNAH7

1.50e-03175895IPR018247
DomainHEAT

PPP2R1B ATR ECPAS

1.55e-0348893PF02985
DomainHomeobox_CS

HOXA3 HOXB3 NANOG TLX3 TLX1

1.96e-03186895IPR017970
DomainDynein_heavy_chain_D4_dom

DNAH7 DNAH1

1.97e-0314892IPR024317
DomainDynein_HC_stalk

DNAH7 DNAH1

1.97e-0314892IPR024743
DomainDynein_heavy_dom-2

DNAH7 DNAH1

1.97e-0314892IPR013602
DomainDHC_N2

DNAH7 DNAH1

1.97e-0314892PF08393
DomainMT

DNAH7 DNAH1

1.97e-0314892PF12777
DomainAAA_8

DNAH7 DNAH1

1.97e-0314892PF12780
DomainDHC_fam

DNAH7 DNAH1

2.26e-0315892IPR026983
DomainDynein_heavy_dom

DNAH7 DNAH1

2.26e-0315892IPR004273
DomainDynein_heavy

DNAH7 DNAH1

2.26e-0315892PF03028
Domain-

HOXA3 HOXB3 ZEB1 NANOG TLX3 TLX1

2.33e-032838961.10.10.60
DomainHEAT

PPP2R1B ATR ECPAS

2.67e-0358893IPR000357
DomainHEAT_type_2

PPP2R1B ATR

2.91e-0317892IPR021133
DomainHomeobox_Antennapedia_CS

HOXA3 HOXB3

4.45e-0321892IPR001827
DomainHEAT_REPEAT

PPP2R1B ATR ECPAS

4.55e-0370893PS50077
DomainEF_hand_dom

MICU3 ITSN2 PPEF2 EFHB DNAH7

5.05e-03232895IPR002048
DomainTPR-like_helical_dom

TMTC3 ATR IFT172 ZFC3H1 PPID

5.14e-03233895IPR011990
DomainKeratin_2_head

KRT8 KRT82

5.79e-0324892IPR032444
DomainANTENNAPEDIA

HOXA3 HOXB3

5.79e-0324892PS00032
DomainKeratin_2_head

KRT8 KRT82

5.79e-0324892PF16208
DomainEF-hand_1

MICU3 ITSN2 PPEF2 EFHB

6.03e-03152894PF00036
DomainKeratin_II

KRT8 KRT82

6.77e-0326892IPR003054
DomainEFh

MICU3 ITSN2 PPEF2 EFHB

6.90e-03158894SM00054
DomainTPR_REGION

TMTC3 IFT172 ZFC3H1 PPID

8.01e-03165894PS50293
DomainTPR

TMTC3 IFT172 ZFC3H1 PPID

8.01e-03165894PS50005
Domain-

MICU3 ITSN2 DMD PPEF2 EFHB

8.21e-032618951.10.238.10
PathwayWP_ID_SIGNALING

RBL2 ELK1 ELK3

3.75e-0516593M39359
PathwayREACTOME_BETA_CATENIN_PHOSPHORYLATION_CASCADE

PPP2R1B CSNK1A1L CSNK1A1

5.43e-0518593MM14759
Pubmed

An FBXW7-ZEB2 axis links EMT and tumour microenvironment to promote colorectal cancer stem cells and chemoresistance.

NANOGP8 CSNK1A1L CSNK1A1 NANOG ELK1 ELK3

3.94e-103396630783098
Pubmed

Hox cofactors in vertebrate development.

HOXA3 HOXB3 TLX3 TLX1

1.13e-081096416515781
Pubmed

Establishment of totipotency does not depend on Oct4A.

KRT8 NANOGP8 NANOG TBX1

2.55e-072096423934214
Pubmed

Maternal Cdx2 is dispensable for mouse development.

KRT8 NANOGP8 NANOG

4.05e-07696322992952
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

MIX23 KRT8 ZBED4 HSPA4L CEBPZ AVIL ITSN2 CAPZA1 CAPZA2 CFAP45 DLEC1 ZFC3H1 DMD CCDC77 STK31 TBX1

2.03e-061442961635575683
Pubmed

Ectopic expression of GATA6 bypasses requirement for Grb2 in primitive endoderm formation.

KRT8 NANOGP8 NANOG

2.41e-061096320925113
Pubmed

Tlx3 and Tlx1 are post-mitotic selector genes determining glutamatergic over GABAergic cell fates.

TLX3 TBX1 TLX1

3.31e-061196315064766
Pubmed

The human cytoplasmic dynein interactome reveals novel activators of motility.

PPP1R2 KRT8 ODF2L CSNK1A1 CEP290 ITSN2 CAPZA1 CCDC77 ECPAS PPID DNAH7 TXLNG

4.16e-06853961228718761
Pubmed

TEAD4 regulates KRT8 and YAP in preimplantation embryos in mice but not in cattle.

KRT8 NANOGP8 NANOG

7.26e-061496338206180
Pubmed

Keratins are asymmetrically inherited fate determinants in the mammalian embryo.

KRT8 NANOGP8 NANOG

7.26e-061496332848249
Pubmed

Systems biology approach identifies the kinase Csnk1a1 as a regulator of the DNA damage response in embryonic stem cells.

CSNK1A1L CSNK1A1

7.54e-06296223354688
Pubmed

Independent regulation of initiation and maintenance phases of Hoxa3 expression in the vertebrate hindbrain involve auto- and cross-regulatory mechanisms.

HOXA3 HOXB3

7.54e-06296211566863
Pubmed

Tissue-specific distribution of mouse casein kinase I alpha mRNA.

CSNK1A1L CSNK1A1

7.54e-0629629522121
Pubmed

Drosophila glucome screening identifies Ck1alpha as a regulator of mammalian glucose metabolism.

CSNK1A1L CSNK1A1

7.54e-06296225994086
Pubmed

CSNK1A1/CK1α suppresses autoimmunity by restraining the CGAS-STING1 signaling.

CSNK1A1L CSNK1A1

7.54e-06296237723657
Pubmed

Casein Kinase 1α Regulates Testosterone Synthesis and Testis Development in Adult Mice.

CSNK1A1L CSNK1A1

7.54e-06296236929849
Pubmed

ZEB1 protects skeletal muscle from damage and is required for its regeneration.

ZEB1 DMD

7.54e-06296230910999
Pubmed

Functional evidence that the self-renewal gene NANOG regulates human tumor development.

NANOGP8 NANOG

7.54e-06296219415763
Pubmed

Nanog1 in NTERA-2 and recombinant NanogP8 from somatic cancer cells adopt multiple protein conformations and migrate at multiple M.W species.

NANOGP8 NANOG

7.54e-06296224598770
Pubmed

Class III β-Tubulin Expression Is of Value in Selecting nab -Paclitaxel and Gemcitabine as First-Line Therapy in Unresectable Pancreatic Cancer.

CSNK1A1L CSNK1A1

7.54e-06296235695793
Pubmed

Differential expression of nanog1 and nanogp8 in colon cancer cells.

NANOGP8 NANOG

7.54e-06296222079639
Pubmed

Exploring the role of casein kinase 1α splice variants across cancer cell lines.

CSNK1A1L CSNK1A1

7.54e-06296238852281
Pubmed

ZEB1 Collaborates with ELK3 to Repress E-Cadherin Expression in Triple-Negative Breast Cancer Cells.

ZEB1 ELK3

7.54e-06296231511359
Pubmed

Casein kinase 1 alpha regulates chromosome congression and separation during mouse oocyte meiotic maturation and early embryo development.

CSNK1A1L CSNK1A1

7.54e-06296223690993
Pubmed

Zeb1 affects epithelial cell adhesion by diverting glycosphingolipid metabolism.

ZEB1 ST3GAL5

7.54e-06296225643708
Pubmed

Csnk1a1 inhibition modulates the inflammatory secretome and enhances response to radiotherapy in glioma.

CSNK1A1L CSNK1A1

7.54e-06296234216174
Pubmed

Casein Kinase 1α as a Novel Factor Affects Thyrotropin Synthesis via PKC/ERK/CREB Signaling.

CSNK1A1L CSNK1A1

7.54e-06296237108197
Pubmed

Tumor-suppressive miRNA-135a inhibits breast cancer cell proliferation by targeting ELK1 and ELK3 oncogenes.

ELK1 ELK3

7.54e-06296229892795
Pubmed

Thymic adult T-cell acute lymphoblastic leukemia stratified in standard- and high-risk group by aberrant HOX11L2 expression: experience of the German multicenter ALL study group.

TLX3 TLX1

7.54e-06296218368072
Pubmed

Knockdown of Csnk1a1 results in preimplantation developmental arrest in mice.

CSNK1A1L CSNK1A1

7.54e-06296236542875
Pubmed

Expression of NANOG and NANOGP8 in a variety of undifferentiated and differentiated human cells.

NANOGP8 NANOG

7.54e-06296221136380
Pubmed

A census of human transcription factors: function, expression and evolution.

HOXA3 HOXB3 ZEB1 ZBED4 CEBPZ NANOG EHF TLX3 ELK1 ELK3 TBX1 TLX1

7.81e-06908961219274049
Pubmed

Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus.

HOXA3 HOXB3 KRT8 NANOGP8 NANOG ELK1 ELK3

8.77e-0626396720932939
Pubmed

Contribution of Hox genes to the diversity of the hindbrain sensory system.

HOXA3 HOXB3 TLX3

1.35e-051796314960494
Pubmed

Identification and functional characterization of transcriptional activators in human cells.

GGH ZEB1 HSPA4L RBL2 ELK1 BCOR PPID PACSIN2

1.51e-0539896835016035
Pubmed

Notch and Hippo signaling converge on Strawberry Notch 1 (Sbno1) to synergistically activate Cdx2 during specification of the trophectoderm.

KRT8 NANOGP8 NANOG

1.61e-051896328401892
Pubmed

The Numb/p53 circuitry couples replicative self-renewal and tumor suppression in mammary epithelial cells.

NANOGP8 ZEB1 NANOG

1.61e-051896326598619
Pubmed

Murine inner cell mass-derived lineages depend on Sall4 function.

KRT8 NANOGP8 NANOG

1.61e-051896317060609
Pubmed

Multiple roles for HOXA3 in regulating thymus and parathyroid differentiation and morphogenesis in mouse.

HOXA3 KRT8 TBX1

1.91e-051996325249461
Pubmed

Transgenerational epigenetic effects imposed by neonicotinoid thiacloprid exposure.

HOXA3 NANOGP8 NANOG STK31

2.06e-055896437973188
Pubmed

Vertebrates have conserved capping protein alpha isoforms with specific expression patterns.

CAPZA1 CAPZA2

2.26e-0539629331217
Pubmed

Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4.

NANOGP8 NANOG

2.26e-05396219447925
Pubmed

Elk3 deficiency causes transient impairment in post-natal retinal vascular development and formation of tortuous arteries in adult murine retinae.

ELK1 ELK3

2.26e-05396225203538
Pubmed

The pluripotency factor NANOG controls primitive hematopoiesis and directly regulates Tal1.

NANOGP8 NANOG

2.26e-05396230814124
Pubmed

The molecular logic of Nanog-induced self-renewal in mouse embryonic stem cells.

NANOGP8 NANOG

2.26e-05396230846691
Pubmed

Generation of germline-competent induced pluripotent stem cells.

NANOGP8 NANOG

2.26e-05396217554338
Pubmed

Multiple phases in regulation of Nanog expression during pre-implantation development.

NANOGP8 NANOG

2.26e-05396226660234
Pubmed

Crystal structure and DNA binding of the homeodomain of the stem cell transcription factor Nanog.

NANOGP8 NANOG

2.26e-05396218177668
Pubmed

Expression of Nanog gene promotes NIH3T3 cell proliferation.

NANOGP8 NANOG

2.26e-05396216259959
Pubmed

Specific interaction of the actin-binding domain of dystrophin with intermediate filaments containing keratin 19.

KRT8 DMD

2.26e-05396216000376
Pubmed

A novel NK-type homeobox gene, ENK (early embryo specific NK), preferentially expressed in embryonic stem cells.

NANOGP8 NANOG

2.26e-05396212609610
Pubmed

Cutting edge: Hypoxia-induced Nanog favors the intratumoral infiltration of regulatory T cells and macrophages via direct regulation of TGF-β1.

NANOGP8 NANOG

2.26e-05396224227785
Pubmed

Nanog co-regulated by Nodal/Smad2 and Oct4 is required for pluripotency in developing mouse epiblast.

NANOGP8 NANOG

2.26e-05396224929238
Pubmed

Nanog and transcriptional networks in embryonic stem cell pluripotency.

NANOGP8 NANOG

2.26e-05396217211451
Pubmed

The pluripotency factor nanog promotes breast cancer tumorigenesis and metastasis.

NANOGP8 NANOG

2.26e-05396223770853
Pubmed

The stem cell pluripotency factor NANOG activates transcription with two unusually potent subdomains at its C terminus.

NANOGP8 NANOG

2.26e-05396215502159
Pubmed

CK1α ablation in keratinocytes induces p53-dependent, sunburn-protective skin hyperpigmentation.

CSNK1A1L CSNK1A1

2.26e-05396228878021
Pubmed

Loss of cIAP1 attenuates soleus muscle pathology and improves diaphragm function in mdx mice.

BIRC2 DMD

2.26e-05396223184147
Pubmed

Nanog variability and pluripotency regulation of embryonic stem cells--insights from a mathematical model analysis.

NANOGP8 NANOG

2.26e-05396220574542
Pubmed

lincRNAs act in the circuitry controlling pluripotency and differentiation.

NANOGP8 NANOG

2.26e-05396221874018
Pubmed

Cell signalling regulates dynamics of Nanog distribution in embryonic stem cell populations.

NANOGP8 NANOG

2.26e-05396223054952
Pubmed

Nanog-independent reprogramming to iPSCs with canonical factors.

NANOGP8 NANOG

2.26e-05396224527385
Pubmed

Type I Interferons Control Proliferation and Function of the Intestinal Epithelium.

CSNK1A1L CSNK1A1

2.26e-05396226811327
Pubmed

Aromatic residues in the C-terminal domain 2 are required for Nanog to mediate LIF-independent self-renewal of mouse embryonic stem cells.

NANOGP8 NANOG

2.26e-05396218086680
Pubmed

Reverse engineering of TLX oncogenic transcriptional networks identifies RUNX1 as tumor suppressor in T-ALL.

TLX3 TLX1

2.26e-05396222366949
Pubmed

Net, a new ets transcription factor that is activated by Ras.

ELK1 ELK3

2.26e-0539627958835
Pubmed

Regulation of Nanog expression by phosphoinositide 3-kinase-dependent signaling in murine embryonic stem cells.

NANOGP8 NANOG

2.26e-05396217204467
Pubmed

CrxOS maintains the self-renewal capacity of murine embryonic stem cells.

NANOGP8 NANOG

2.26e-05396219800316
Pubmed

Chromatin decondensation and nuclear softening accompany Nanog downregulation in embryonic stem cells.

NANOGP8 NANOG

2.26e-05396223200040
Pubmed

Selenium Augments microRNA Directed Reprogramming of Fibroblasts to Cardiomyocytes via Nanog.

NANOGP8 NANOG

2.26e-05396226975336
Pubmed

Nanog suppresses cell migration by downregulating thymosin β4 and Rnd3.

NANOGP8 NANOG

2.26e-05396223329853
Pubmed

NANOG alone induces germ cells in primed epiblast in vitro by activation of enhancers.

NANOGP8 NANOG

2.26e-05396226751055
Pubmed

Epigenetic regulation of Nanog gene in embryonic stem and trophoblast stem cells.

NANOGP8 NANOG

2.26e-05396217352742
Pubmed

Mammalian casein kinase 1alpha and its leishmanial ortholog regulate stability of IFNAR1 and type I interferon signaling.

CSNK1A1L CSNK1A1

2.26e-05396219805514
Pubmed

Clinical significance of HOX11L2 expression linked to t(5;14)(q35;q32), of HOX11 expression, and of SIL-TAL fusion in childhood T-cell malignancies: results of EORTC studies 58881 and 58951.

TLX3 TLX1

2.26e-05396214504110
Pubmed

OCT4/SOX2-independent Nanog autorepression modulates heterogeneous Nanog gene expression in mouse ES cells.

NANOGP8 NANOG

2.26e-05396223178592
Pubmed

Stochastic NANOG fluctuations allow mouse embryonic stem cells to explore pluripotency.

NANOGP8 NANOG

2.26e-05396225005472
Pubmed

Roles of the Nanog protein in murine F9 embryonal carcinoma cells and their endoderm-differentiated counterparts.

NANOGP8 NANOG

2.26e-05396216773043
Pubmed

Genome-wide chromatin interactions of the Nanog locus in pluripotency, differentiation, and reprogramming.

NANOGP8 NANOG

2.26e-05396223665121
Pubmed

Ectopic overexpression of Nanog induces tumorigenesis in non-tumorous fibroblasts.

NANOGP8 NANOG

2.26e-05396226733157
Pubmed

mNanog possesses dorsal mesoderm-inducing ability by modulating both BMP and Activin/nodal signaling in Xenopus ectodermal cells.

NANOGP8 NANOG

2.26e-05396223071603
Pubmed

Overexpression of NANOG in human ES cells enables feeder-free growth while inducing primitive ectoderm features.

NANOGP8 NANOG

2.26e-05396216501172
Pubmed

Regulated fluctuations in nanog expression mediate cell fate decisions in embryonic stem cells.

NANOGP8 NANOG

2.26e-05396219582141
Pubmed

NANOG induction of fetal liver kinase-1 (FLK1) transcription regulates endothelial cell proliferation and angiogenesis.

NANOGP8 NANOG

2.26e-05396221119109
Pubmed

Pluripotency factor NANOG promotes germ cell maintenance in vitro without triggering dedifferentiation of spermatogonial stem cells.

NANOGP8 NANOG

2.26e-05396232145514
Pubmed

Nanog is the gateway to the pluripotent ground state.

NANOGP8 NANOG

2.26e-05396219703398
Pubmed

Nanog safeguards pluripotency and mediates germline development.

NANOGP8 NANOG

2.26e-05396218097409
Pubmed

Nanog Fluctuations in Embryonic Stem Cells Highlight the Problem of Measurement in Cell Biology.

NANOGP8 NANOG

2.26e-05396228636920
Pubmed

Heterogeneities in Nanog Expression Drive Stable Commitment to Pluripotency in the Mouse Blastocyst.

NANOGP8 NANOG

2.26e-05396225753417
Pubmed

Solution NMR structure of S100B bound to the high-affinity target peptide TRTK-12.

CAPZA1 CAPZA2

2.26e-05396212470955
Pubmed

Csnk1a1 inhibition has p53-dependent therapeutic efficacy in acute myeloid leukemia.

CSNK1A1L CSNK1A1

2.26e-05396224616378
Pubmed

A distinct expression pattern in mammalian testes indicates a conserved role for NANOG in spermatogenesis.

NANOGP8 NANOG

2.26e-05396220539761
Pubmed

Global mapping of DNA methylation in mouse promoters reveals epigenetic reprogramming of pluripotency genes.

NANOGP8 NANOG

2.26e-05396218584034
Pubmed

Adhesion regulates MAP kinase/ternary complex factor exchange to control a proliferative transcriptional switch.

ELK1 ELK3

2.26e-05396223063436
Pubmed

Alternative splicing produces Nanog protein variants with different capacities for self-renewal and pluripotency in embryonic stem cells.

NANOGP8 NANOG

2.26e-05396221969378
Pubmed

The phosphoinositide-3-kinase/Akt pathway mediates the transient increase in Nanog expression during differentiation of F9 cells.

NANOGP8 NANOG

2.26e-05396220661723
Pubmed

NANOG restores the impaired myogenic differentiation potential of skeletal myoblasts after multiple population doublings.

NANOGP8 NANOG

2.26e-05396229245050
Pubmed

Capping protein regulates endosomal trafficking by controlling F-actin density around endocytic vesicles and recruiting RAB5 effectors.

CAPZA1 CAPZA2

2.26e-05396234796874
Pubmed

Cancer vaccination drives Nanog-dependent evolution of tumor cells toward an immune-resistant and stem-like phenotype.

NANOGP8 NANOG

2.26e-05396222337995
Pubmed

A new recurrent and specific cryptic translocation, t(5;14)(q35;q32), is associated with expression of the Hox11L2 gene in T acute lymphoblastic leukemia.

TLX3 TLX1

2.26e-05396211587205
InteractionDGKZ interactions

CEBPZ RBL2 CAPZA1 ZFC3H1 DMD ZRANB1

5.38e-0699906int:DGKZ
InteractionNINL interactions

KRT8 ODF2L CSNK1A1 CEP290 ITSN2 CAPZA1 CAPZA2 ZFC3H1 CCDC77 TXLNG DNAH1

6.13e-064589011int:NINL
InteractionKDM2B interactions

NANOG TLX3 ELK3 BCOR ECPAS ZRANB1 TLX1

7.81e-06161907int:KDM2B
Cytoband12q21.32

TMTC3 CEP290

1.20e-04896212q21.32
GeneFamilyNKL subclass homeoboxes and pseudogenes

NANOGP8 NANOG TLX3 TLX1

7.67e-0567614519
GeneFamilyETS transcription factor family

EHF ELK1 ELK3

1.13e-0428613534
GeneFamilyEF-hand domain containing

MICU3 ITSN2 PPEF2 EFHB DNAH7

8.54e-04219615863
GeneFamilyDyneins, axonemal

DNAH7 DNAH1

1.47e-0317612536
GeneFamilyBardet-Biedl syndrome associated|BBSome

IFT172 CEP290

2.26e-0321612980
GeneFamilyKeratins, type II

KRT8 KRT82

3.72e-0327612609
ToppCellLPS_IL1RA_TNF-Epithelial_airway-airway_epithelial|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

ODF2L EHF CFAP45 DLEC1 EFHB ANKFN1 DNAH7 DNAH1 LRRC9

4.78e-10200959da12821e8a0657869ca0f75d351cce2d7605a505
ToppCellLPS_IL1RA_TNF-Epithelial_airway|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

ODF2L EHF CFAP45 DLEC1 EFHB ANKFN1 DNAH7 DNAH1 LRRC9

4.78e-1020095972c1d9eeaed4b3ee6b6c602e8aa29efc2e8744eb
ToppCellLPS_IL1RA_TNF-Epithelial_airway-airway_epithelial-Ciliated|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

PLEKHG7 CFAP45 DLEC1 EFHB ANKFN1 DNAH7 DNAH1 LRRC9

1.16e-0820095896701a4d57753f5ec0dd5c7550054bbcc946bc5f
ToppCellControl-Epithelial_airway-Ciliated_cells-Ciliated|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CFAP45 DLEC1 EFHB ANKFN1 DNAH7 DNAH1 LRRC9

4.12e-081549574e3bc24043144143842627cacf6f90dda2228910
ToppCellControl-Epithelial_airway-Ciliated_cells|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CFAP45 DLEC1 EFHB ANKFN1 DNAH7 DNAH1 LRRC9

4.12e-081549577556a4b2b062da5ae7ec2bbb66e745e7662db628
ToppCellLPS-IL1RA+antiTNF-Epithelial_airway-Ciliated_cells|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CFAP45 DLEC1 EFHB ANKFN1 DNAH7 DNAH1 LRRC9

4.31e-081559575f1e2195a6b831e1b636f5cc3a282ca423721822
ToppCellLPS-IL1RA+antiTNF-Epithelial_airway-Ciliated_cells-Ciliated|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CFAP45 DLEC1 EFHB ANKFN1 DNAH7 DNAH1 LRRC9

4.31e-081559570944429459f642a1bcc56edc1ec28aaecde3e2dc
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ODF2L PLEKHG7 DZIP3 DLEC1 EFHB ANKFN1 DNAH7

7.79e-0816995714aadc2d1bf66eb47dac33b4d61ddb3c942caa4f
ToppCelldroplet-Lung-LUNG-1m-Myeloid-Ccr7+_Dendritic|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC4A8 ATR EHF BIRC2 DLEC1 ZFC3H1 TRIM7

9.51e-081749577be0c6248e77f2d0260b852b01e17892f7828f1b
ToppCelldroplet-Lung-1m-Hematologic-myeloid-myeloid_dendritic_cell-Ccr7+_dendritic|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SLC4A8 ATR EHF BIRC2 DLEC1 ZFC3H1 TRIM7

9.89e-081759571b910c08d2bfbcc77431ee66103e63a11a9d39fe
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

C1orf232 SLC4A8 CFAP45 TRIM31 DLEC1 DNAH7 DNAH1

1.11e-071789573b12db04006db6e94fc45649a4b3a63b92f21a61
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

C1orf232 ODF2L DLEC1 EFHB ANKFN1 DNAH7 DNAH1

1.20e-0718095792fb01b91261b3103454924cde56add337b41844
ToppCellLPS_only-Epithelial_airway-airway_epithelial-Ciliated|LPS_only / Treatment groups by lineage, cell group, cell type

PLEKHG7 CFAP45 DLEC1 ANKFN1 DNAH7 DNAH1 LRRC9

2.29e-071989576d90b541fde357fbb40f8f7d4e8628a48b679718
ToppCellLPS_IL1RA-Epithelial_airway-airway_epithelial-Ciliated|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

SLC4A8 CFAP45 DLEC1 EFHB ANKFN1 DNAH7 DNAH1

2.45e-072009574992dbf0514d674017315dbd20d91dfec0c608e9
ToppCellLPS_only-Epithelial_airway-Ciliated_cells-Ciliated|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PLEKHG7 DLEC1 ANKFN1 DNAH7 DNAH1 LRRC9

9.86e-071549569ca71d440c4f87781e6525b8141e7d8d470b6a8e
ToppCellLPS_only-Epithelial_airway-Ciliated_cells|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PLEKHG7 DLEC1 ANKFN1 DNAH7 DNAH1 LRRC9

9.86e-0715495658072ce422d09f2de602580325eaac6c4ec6c136
ToppCellsaliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Macrophage|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

GGH CSNK1A1L CEBPZ FXN BCOR DNAH7

1.47e-06165956436ce4bc75e1ba4351c439ccad19f84ad5bcb92f
ToppCellsaliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Macrophage-macrophage,_alveolar|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

GGH CSNK1A1L CEBPZ FXN BCOR DNAH7

1.47e-06165956242bdb7654f415391fb8e9bdc06412c7eee9c97e
ToppCellPCW_07-8.5-Epithelial-Epithelial_ciliated-epi_ciliated_(14)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

EHF CFAP45 DLEC1 DNAH7 TBX1 LRRC9

1.47e-061659560c714e852f912b5749de4cb0895406673979b2e6
ToppCellPCW_07-8.5-Epithelial-Epithelial_ciliated|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

EHF CFAP45 DLEC1 DNAH7 TBX1 LRRC9

1.47e-0616595682530f96aaefe28a13bad0474bbad043f127a86c
ToppCellsaliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

PLEKHG7 CFAP45 DLEC1 UNC5D TBX1 DNAH1

1.64e-061689569a8709d34865cfa668d8f3335dc34fc86fc32482
ToppCellCiliated_cells-B-Myositis-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

PLEKHG7 CFAP45 DZIP3 DLEC1 EFHB DNAH7

2.86e-06185956f012c243343e1d1956db19b34d062e9b13de2b2a
ToppCellAdult-Epithelial-ciliated_cell-D231|Adult / Lineage, Cell type, age group and donor

PLEKHG7 CFAP45 DLEC1 EFHB ANKFN1 DNAH7

3.14e-0618895634b11f72ca73153d02edcd09b38983ad1a504659
ToppCellASK452-Epithelial-Ciliated|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq

ODF2L EHF CFAP45 DZIP3 EFHB DNAH7

3.65e-06193956c0d10075862ac878aa05fc49c8b73e470783bf16
ToppCell3'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PLEKHG7 CFAP45 DZIP3 EFHB ANKFN1 DNAH7

3.76e-061949563cd90d01ed5a5ce65aad8284dab2537ec16e3d7c
ToppCell3'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PLEKHG7 CFAP45 DZIP3 DLEC1 EFHB DNAH7

3.87e-0619595679dc031258579ea328181dda33710dd897f1064a
ToppCellControl_saline-Epithelial_airway-airway_epithelial-Ciliated|Control_saline / Treatment groups by lineage, cell group, cell type

CFAP45 DLEC1 EFHB DNAH7 DNAH1 LRRC9

3.87e-0619595660067b5359174f0d1a8b5748bfc0690762e9e740
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IFT172 CFAP45 DZIP3 DLEC1 EFHB DNAH7

4.11e-0619795691637bdeab85024b5a02d1066f76cb803a2d6420
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IFT172 CFAP45 DZIP3 DLEC1 EFHB DNAH7

4.11e-0619795622c87dd15dc57bd0aa98a204c9fc9b3b9b573b45
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ODF2L CEP290 DLEC1 DMD DNAH7 LRRC9

4.11e-0619795674a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IFT172 CFAP45 DZIP3 DLEC1 EFHB DNAH7

4.11e-061979563bbf068d2ad8196fbc85d3f311a7c54c9aece856
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IFT172 CFAP45 DZIP3 DLEC1 EFHB DNAH7

4.11e-0619795687db09f341e2b20eb6e1c3e917cb5c960387b3e9
ToppCellLPS_anti-TNF-Epithelial_airway-airway_epithelial-Ciliated|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

SLC4A8 CFAP45 DLEC1 EFHB DNAH7 DNAH1

4.35e-0619995615f7814b7074170eee7ccacaa670b1d128fc68bb
ToppCellBronchus_Control_(B.)-Epithelial-TX-Ciliated|Bronchus_Control_(B.) / Sample group, Lineage and Cell type

IFT172 CFAP45 DZIP3 DLEC1 EFHB DNAH7

4.48e-062009566a2ccc71a0cbe04a542c379b28b5006de53981c3
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_ciliated-Ciliated|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PLEKHG7 CFAP45 DLEC1 EFHB ANKFN1 DNAH7

4.48e-06200956926a7ea94b5908aebf103893ea83ce9d25285b65
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_ciliated|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PLEKHG7 CFAP45 DLEC1 EFHB ANKFN1 DNAH7

4.48e-0620095606ce6e03498ba38ef6a06eaf2731e3b2eeda59eb
ToppCellParenchymal-10x3prime_v2-Stromal-Myofibroblastic-Muscle_perivascular_immune_recruiting|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

KANSL3 HOXB3 MICU3 STON1 TP53TG5 PACSIN2

4.48e-06200956a372ef3f9e6ff6e3c3376d6e10182977c5067788
ToppCelldroplet-Heart-HEART-1m-Hematologic-nan|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ODF2L ST3GAL5 HSPA4L NOL10 PFKFB4

7.83e-06127955983489a69d3b1f1fe21110a862ac1dba53e9d31c
ToppCellLPS-antiTNF-Epithelial_airway-Ciliated_cells-Ciliated|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CFAP45 DLEC1 ANKFN1 DNAH7 LRRC9

1.64e-05148955d61123f0c811287843d066b932b4a9ff09c07c5b
ToppCellLPS-antiTNF-Epithelial_airway-Ciliated_cells|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CFAP45 DLEC1 ANKFN1 DNAH7 LRRC9

1.64e-05148955c8e93b87212f55774223caa385859c566fa1981f
ToppCellLPS-IL1RA-Epithelial_airway-Ciliated_cells|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DLEC1 EFHB ANKFN1 DNAH1 LRRC9

1.81e-0515195581cf939ed4df9574fbfff265e109cb9f947d7e6e
ToppCellLPS-IL1RA-Epithelial_airway-Ciliated_cells-Ciliated|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DLEC1 EFHB ANKFN1 DNAH1 LRRC9

1.81e-051519559cbcbbc22965a9f0be8364e733d205dd64f2a533
ToppCelldroplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STON1 ATR CFAP45 TBC1D22B TBX1

2.18e-05157955a426c54fd1545093d41426e9620862f71bd06f6b
ToppCelldroplet-Heart-nan-24m-Mesenchymal-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ODF2L CD247 HSPA4L CFAP45 TLX1

2.94e-05167955a35ace2c722936d2a3e1f0826e5b6ec6b1340d2b
ToppCellCiliated_cells-B-IPF_04|World / lung cells shred on cell class, cell subclass, sample id

ODF2L CFAP45 DZIP3 EFHB DNAH7

3.38e-05172955187ae91148d293537afc77e10da2b64302322224
ToppCell3'-Distal_airway-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PLEKHG7 CFAP45 DLEC1 EFHB DNAH7

3.47e-05173955c3762655caa79ac4879876f470d32578a3c93b01
ToppCell3'-Pediatric_IBD-SmallIntestine-Epithelial-Tuft-related-Tuft|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HOXA3 KRT8 PLEKHG7 IFT172 AVIL

3.98e-05178955f17c3b7bb562ac24c6a03fe3c9ba94c2b434c141
ToppCell5'-Adult-LargeIntestine-Epithelial-Tuft-related-Microfold_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GGH PLBD1 KRT8 EHF TRIM31

4.31e-051819554d7d367f4ed390908888391335c714a22b5a75c4
ToppCellFetal_29-31_weeks-Epithelial-ciliated_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

PLEKHG7 CFAP45 DLEC1 ANKFN1 DNAH7

4.31e-05181955dfce05bd472f67e6e2bb60ebd6fd34f0a9aeeca6
ToppCellE17.5-Epithelial-airway_epithelial_cell|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

KRT8 HSPA4L EHF CFAP45 TBX1

4.54e-0518395507cebb0e186e1bff14ac2a6bb6f8412d4aaa2350
ToppCellE17.5-Epithelial-airway_epithelial_cell-club_cell|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

KRT8 HSPA4L EHF CFAP45 TBX1

4.54e-05183955e8e85e5be909f9cd85a6a041190bfcb855dfa1a4
ToppCell3'-Child04-06-SmallIntestine-Epithelial-Tuft-related-Tuft|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HOXA3 KRT8 IFT172 AVIL EHF

4.78e-05185955686ed7550c6acd18e71e0076936ec5b07389adbd
ToppCellAdult-Epithelial-ciliated_cell-D175|Adult / Lineage, Cell type, age group and donor

PLEKHG7 CFAP45 DLEC1 ANKFN1 DNAH7

4.78e-0518595530f4980dee6cd5959655f8d74049f3bfb5312611
ToppCellNS-critical-d_16-33-Epithelial-Ciliated|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CFAP45 DZIP3 DLEC1 EFHB DNAH7

4.91e-0518695576033438426d8f9c72cd6691a7baf92104c9f03d
ToppCellNS-moderate-d_07-13-Epithelial-Ciliated|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CFAP45 DLEC1 EFHB ANKFN1 DNAH7

4.91e-0518695585787ff207f109ec7e3c0f729ba9bda739c2fdc9
ToppCellFetal_29-31_weeks-Epithelial-ciliated_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

PLEKHG7 CFAP45 DLEC1 ANKFN1 DNAH7

5.03e-051879559e10ed56090d82589bc457788282f664b70ace4b
ToppCellChildren_(3_yrs)-Epithelial-ciliated_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

CFAP45 DLEC1 EFHB ANKFN1 DNAH7

5.16e-051889552b6dfc88be9ded7b88da9fe78a9cd9f9b3af8af3
ToppCellCOVID-19-lung-Ciliated|COVID-19 / Disease (COVID-19 only), tissue and cell type

PLEKHG7 CFAP45 DLEC1 ANKFN1 DNAH7

5.29e-05189955a2da5debd10f27b1280b40141ef0bfef007cc72c
ToppCellChildren_(3_yrs)-Epithelial-ciliated_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

CFAP45 DLEC1 EFHB ANKFN1 DNAH7

5.29e-0518995568a3cf7763d6f9b95d6d6524eff7a16042703f1d
ToppCellAdult-Epithelial-ciliated_cell|Adult / Lineage, Cell type, age group and donor

PLEKHG7 CFAP45 DLEC1 ANKFN1 DNAH7

5.29e-05189955b679920f0993e917dd86da082113bfbd85ea1ca5
ToppCellCOVID-19-lung-Ciliated|lung / Disease (COVID-19 only), tissue and cell type

PLEKHG7 CFAP45 DLEC1 ANKFN1 DNAH7

5.29e-0518995527329c4661aebabd19fac7fe5dca263fe99d76f3
ToppCellEpithelial_cells-Ciliated_cells-B|Epithelial_cells / lung cells shred on cell class, cell subclass, sample id

CFAP45 DZIP3 DLEC1 EFHB DNAH7

5.43e-05190955426a4806f6e39d4d57c6746609d30bb3ca62df7d
ToppCellPCW_13-14-Epithelial-Epithelial_neuroendo-epi_NE_progenitor_(7)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

KRT8 ST3GAL5 EHF DMD TBX1

5.56e-0519195563aa671837b79d2feb7ed1e67712cc01caf72bef
ToppCell3'-Child04-06-SmallIntestine-Epithelial-Tuft-related|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HOXA3 KRT8 IFT172 AVIL EHF

5.70e-05192955d6ea34391c3f730684b82e912d9cf55e928b3311
ToppCellwk_20-22-Epithelial-Proximal_epithelial-MUC16+_ciliated|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

COL28A1 CFAP45 DLEC1 EFHB DNAH7

5.99e-05194955756082a0f5953b52229bb60d40b84701cb6cb23d
ToppCellASK440-Epithelial-Ciliated|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq

ODF2L CFAP45 DZIP3 EFHB DNAH7

5.99e-05194955c84a7fa94fb06e08aae04db56c8c313b0afde1d7
ToppCellNS-critical-d_07-13-Epithelial-Ciliated|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CFAP45 DLEC1 EFHB ANKFN1 DNAH7

5.99e-051949551ae8a10e508e672e6677f0e3c986ac30d05adeb3
ToppCellPCW_13-14-Epithelial-Epithelial_airway|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

KRT8 ST3GAL5 EHF DMD TBX1

5.99e-051949557b2b40a56eb9c7203ca50133b2da4fd8fdd4a5cf
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

COL28A1 DZIP3 DLEC1 EFHB DNAH7

5.99e-051949554a2c127c90d1fefe604fcb9e796577d21b489dd6
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IFT172 CFAP45 DZIP3 EFHB DNAH7

5.99e-05194955a46238514bca920c3e3713d23c18ba24a09e2a29
ToppCell3'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PLEKHG7 CFAP45 DZIP3 EFHB DNAH7

6.14e-05195955db4270c135c392ed443670981656e3cd5b95939d
ToppCellmoderate-Epithelial-Ciliated|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

CFAP45 DZIP3 DLEC1 EFHB DNAH7

6.14e-051959553486eae5fdb062a75a907b896c9d7b396d2aa195
ToppCell3'-Airway_Nasal-Epithelial-Airway_ciliated|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PLEKHG7 CFAP45 DZIP3 EFHB DNAH7

6.14e-051959556365e3893e38231090ec2dbef010dec71dea3d07
ToppCellBronchial-10x5prime-Immune_Lymphocytic-NK-ILC-T_NK-ILC|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

MORC1 CD247 ZBED4 KLRF2 DZIP3

6.29e-051969551cc2b11764584129703ec61965e8ec4e051464e7
ToppCellcellseq-Epithelial-Epithelial_Airway|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

KRT8 HSPA4L IFT172 EHF TRIM7

6.29e-05196955faa39c567f24403e511b240c1d1a654ffadd8473
ToppCellNS-critical-d_0-4-Epithelial-Ciliated-diff|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

KRT8 CFAP45 DZIP3 EFHB DNAH7

6.44e-0519795562e20ef825b92908d7732aa625dcff7b95ef6ca8
ToppCellTracheal-10x5prime-Epithelial-Epi_airway_ciliated-Deuterosomal|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

CFAP45 DLEC1 EFHB DNAH7 DNAH1

6.44e-051979556e4a411ef823ce9e16f420e185e21fa19d13af34
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.4|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IFT172 CFAP45 DZIP3 EFHB DNAH7

6.44e-05197955d83c61d2b5742e463122e1a98c7197a5b5b3d41b
ToppCellcontrol-Epithelial-Ciliated|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

CFAP45 DZIP3 DLEC1 EFHB DNAH7

6.44e-05197955d4e963c1f82996371bf3d63578ee9fce8e00c5a8
ToppCellControl_saline-Epithelial_airway|Control_saline / Treatment groups by lineage, cell group, cell type

EHF CFAP45 DLEC1 DNAH7 DNAH1

6.60e-05198955e6863238e022ecfb6a8e3f4b7661b376e92c5d8f
ToppCellControl_saline-Epithelial_airway-airway_epithelial|Control_saline / Treatment groups by lineage, cell group, cell type

EHF CFAP45 DLEC1 DNAH7 DNAH1

6.60e-05198955e7aa42e5fbd42c68f50cda4a8f3aa464c862c007
ToppCellLPS_only-Epithelial_airway-airway_epithelial|LPS_only / Treatment groups by lineage, cell group, cell type

ODF2L EHF ANKFN1 DNAH7 DNAH1

6.60e-05198955e035380578c01b0243bfef29ca9b50cc17cce771
ToppCellLPS_only-Epithelial_airway|LPS_only / Treatment groups by lineage, cell group, cell type

ODF2L EHF ANKFN1 DNAH7 DNAH1

6.60e-05198955ba090210392e001a3f7bdf09371b3f0e0c8c7ef3
ToppCellBAL-Mild-Epithelial-Epithelial|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

KRT8 PLEKHG7 EHF CFAP45 DNAH7

6.75e-051999551ee4010d8557564e25e8ee00b914c2dfd9037838
ToppCellBAL-Mild-Epithelial|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

KRT8 PLEKHG7 EHF CFAP45 DNAH7

6.75e-0519995574087b4b5e567310fc4ac58fb267ff651a180680
ToppCellLPS_anti-TNF-Epithelial_airway-airway_epithelial|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

ODF2L CFAP45 DLEC1 DNAH7 DNAH1

6.75e-0519995560919c2af31d39a2d36d7bc432e43dab2a4e05fb
ToppCellCaecum-(5)_Dendritic_cell-(51)_cDC1|Caecum / shred on region, Cell_type, and subtype

HOXA3 PLBD1 EHF ARHGAP20 INPP5J

6.75e-051999552b97fda45241b2ce7be904cf081cabcf3eb5ba1d
ToppCellLPS_IL1RA_TNF-Epithelial_airway-airway_epithelial-Airway-Club|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

ODF2L EHF CFAP45 CRISP3 LRRC9

6.75e-051999558649c2380285a668782d75eb076ce548eed0911d
ToppCelldistal-Epithelial-Ciliated-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

IFT172 CFAP45 DLEC1 EFHB DNAH7

6.75e-051999556ce0df4a6f4d9353919e26ffab97c9ec89911da6
ToppCellCaecum-Dendritic_cell-cDC1|Caecum / Region, Cell class and subclass

HOXA3 PLBD1 EHF ARHGAP20 INPP5J

6.75e-051999559ab38a0060a883de6fe3da8cdac42e124d7981d9
ToppCellLPS_anti-TNF-Epithelial_airway|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

ODF2L CFAP45 DLEC1 DNAH7 DNAH1

6.75e-051999556aca164bbbb961f34b1e6f1857f91ade5c059405
ToppCell(10)_Ciliated|World / shred by cell type by condition

CFAP45 DZIP3 DLEC1 EFHB DNAH7

6.92e-052009551b6a8025bd2746b626040058c122b1be3ab2fa61
ToppCellBronchial-10x5prime-Epithelial-Epi_airway_ciliated-Ciliated|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

CFAP45 DLEC1 EFHB ANKFN1 DNAH7

6.92e-0520095555c148238d5c80c1faa3428a917ae8075be2c145
ToppCellLPS_IL1RA-Epithelial_airway-airway_epithelial|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

ODF2L SLC4A8 EHF DLEC1 DNAH7

6.92e-05200955cf191104484bfb2b9f87de416b9453135f8833c1
ToppCellTracheal-10x5prime-Epithelial-Epi_airway_ciliated|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

CFAP45 DLEC1 ANKFN1 DNAH7 DNAH1

6.92e-0520095531d75c26055177d656df1fbb10b764cebd61e122
ToppCellParenchymal-10x5prime-Epithelial-Epi_airway_ciliated|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

CFAP45 DLEC1 EFHB ANKFN1 DNAH7

6.92e-0520095585c98da55f7cd4ffdf9d309b56c8cc5d43f3c04c
ToppCellBiopsy_IPF-Epithelial-Ciliated|Biopsy_IPF / Sample group, Lineage and Cell type

IFT172 CFAP45 DZIP3 DLEC1 DNAH7

6.92e-05200955bb8c99156e547a8eb6599b6b6bc3c66bf77af7f8
ToppCellLPS_IL1RA-Epithelial_airway|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

ODF2L SLC4A8 EHF DLEC1 DNAH7

6.92e-05200955a5ae33dd4dc1ff6e1a1eec22c4d523d5ab657607
ToppCell(09)_Interm._secr.>cil.|World / shred by cell type by condition

CFAP45 DZIP3 DLEC1 EFHB DNAH7

6.92e-052009553305e14dba12e94da42f0414fdc7a2c8caf0a183
ToppCellTracheal-10x5prime-Epithelial-Epi_airway_ciliated-Ciliated|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

CFAP45 DLEC1 ANKFN1 DNAH7 DNAH1

6.92e-05200955e1dce91c6c531bb212002a14705e496d77ad3490
Diseasecolon cancer (implicated_via_orthology)

NANOGP8 ATR NANOG

5.07e-0611943DOID:219 (implicated_via_orthology)
Diseasesyndromic X-linked intellectual disability Najm type (implicated_via_orthology)

CSNK1A1L CSNK1A1

2.09e-047942DOID:0060807 (implicated_via_orthology)
DiseaseEmbryonal Rhabdomyosarcoma

DMD BCOR

2.78e-048942C0206656
Diseasecystic kidney disease (implicated_via_orthology)

IFT172 CEP290

4.44e-0410942DOID:2975 (implicated_via_orthology)
DiseaseBardet-Biedl Syndrome

IFT172 CEP290

7.65e-0413942C0752166
DiseaseDiGeorge syndrome (implicated_via_orthology)

HOXA3 TBX1

1.66e-0319942DOID:11198 (implicated_via_orthology)
DiseaseSevere Combined Immunodeficiency

CD247 TBX1

1.84e-0320942C0085110
Diseaseairway responsiveness measurement

DZIP3 ANKFN1

2.65e-0324942EFO_0006897
Diseasehypertension

HOXA3 HOXB3 STON1 CAPZA1 HECTD4

3.05e-03307945EFO_0000537
DiseaseUterine leiomyoma

ZEB1 STON1 PLEKHM3

3.11e-0391943HP_0000131

Protein segments in the cluster

PeptideGeneStartEntry
NNLMKLVQKFGTEWA

PPP2R1B

476

P30154
SAMFKQLFQKWSVKD

AVIL

336

O75366
QLFQKWSVKDQTMGL

AVIL

341

O75366
WGLRKNKTNMNYDKL

ELK1

46

P19419
WNKILSYKIGKEMQN

CAPZA1

271

P52907
TKKWSLNDLQMIDGK

EXOC1L

66

A0A1B0GW35
NQNKEKSWMLEKDNL

CCDC77

296

Q9BR77
MNQAFWKTYKSKVLQ

C1orf232

1

A0A0U1RR37
NMNFKWSELRKKSLN

DMD

2781

P11532
NGKSMSLKNKALDWA

BCOR

521

Q6W2J9
ETKIAKWNLQSRMNK

ODF2L

211

Q9ULJ1
NWKELIMSNTKLLKA

ITSN2

1256

Q9NZM3
QKSVSDMIKEFRKNW

PARPBP

6

Q9NWS1
FLEQQNKMLETKWSL

KRT8

111

P05787
NKMLETKWSLLQQQK

KRT8

116

P05787
LKWASFSNNNLTKME

LRRC9

911

Q6ZRR7
LKNAQAASWEMKRKQ

MORC1

691

Q86VD1
SEQSLIEFFNKMKKW

RBL2

121

Q08999
WNVKKQSVYLMNLRK

FXN

66

Q16595
RNWDMKAALQKLFSK

OR1A2

291

Q9Y585
FPWMKESRQNTKQKT

HOXA3

156

O43365
SKKSQKWDEMNILAT

PPP1R2P1

41

Q96PQ5
LQSVKQYWKQADKIM

DDX60L

911

Q5H9U9
QKEMVWNNNKKLSDL

CFAP45

151

Q9UL16
ITQKALQSQSWKMKA

ECPAS

1531

Q5VYK3
QRWEGFQQKLMSKKN

CSTL1

26

Q9H114
DQNIKDLKVWTSQMK

PFKFB4

291

Q16877
QEIMEKYNIKLKWTN

CFHR2

211

P36980
MSKQSLQVLKKCWAF

HERC6

511

Q8IVU3
YKQVKTWFQNQRMKS

NANOG

136

Q9H9S0
LEQKNKLLETKWNFM

KRT82

141

Q9NSB4
KTWKSLSKQELNQML

MICU3

181

Q86XE3
FDWTMLKQKAAQQAA

CSNK1A1L

296

Q8N752
KMWNKNSGKIFTSLE

NOL10

296

Q9BSC4
QKKQKSFWQRLNMDE

PLEKHM3

731

Q6ZWE6
KQKVATMAWAAFQVL

HECTD4

1316

Q9Y4D8
KNLKEQLSMKRSQWE

DZIP3

821

Q86Y13
SKKSQKWDEMNILAT

PPP1R2

41

P41236
QDFMEKQDKWTRKNI

PLBD1

136

Q6P4A8
AANKDNWNKFLMAIK

IFT172

1706

Q9UG01
KASLMNDDFEKIKNW

PACSIN2

101

Q9UNF0
PQSQANKWIKNMEKD

DNAH1

3236

Q9P2D7
MNQKSILWSALKQKA

ATR

456

Q13535
IDLKFWHKKMDFSQN

KLRF2

51

D3W0D1
WKDLQTFKQKVKSMN

COL28A1

111

Q2UY09
LKMEWNKEAAANAQK

CRISP3

61

P54108
KWSLSVKNFTMNEKL

GGH

196

Q92820
LNKFKQTAWDLMKQS

CEP290

1596

O15078
MKWKALFTAAILQAQ

CD247

1

P20963
TLKWKIFTNFKMNIL

CCR8

191

P51685
AQLWGKKKNNSSMTY

EHF

246

Q9NZC4
QANKWIKNMEKANSL

DNAH7

2996

Q8WXX0
AFDMLWKLQKQKTSL

FASTKD1

71

Q53R41
PWMKESRQTSKLKNN

HOXB3

131

P14651
VAKLWGLRKNKTNMN

ELK3

41

P41970
EFANFLNWKDKMLLK

EFHB

621

Q8N7U6
GWTMAQNKLFNKILK

KANSL3

131

Q9P2N6
WKNKDITMQSTKQYA

FBXL5

431

Q9UKA1
ESNLKTKLKAMWQGE

CCDC168

2421

Q8NDH2
VKSFVMNFKNNNSKW

DCBLD1

341

Q8N8Z6
MNFKNNNSKWKTYKG

DCBLD1

346

Q8N8Z6
QSFDKEWVAKQTKRM

COX4I1

131

P13073
IGINVKKAFKMWNNS

DLEC1

771

Q9Y238
AMANKDNASLKQLRW

CEBPZ

1001

Q03701
NMLEYKSWLKNLAKE

PPEF2

621

O14830
NNFKIKNKIKLTDMW

ARHGAP20

121

Q9P2F6
NRFFKSMNKNDMKSW

TRIM31

306

Q9BZY9
SMNKNDMKSWGLLQK

TRIM31

311

Q9BZY9
MAAENSKQFWKRSAK

TBC1D22B

1

Q9NU19
YKQVKTWFQNQRMKS

NANOGP8

136

Q6NSW7
FDWTMLKQKAAQQAA

CSNK1A1

296

P48729
NTFFKSQNWEMAIKK

PPID

231

Q08752
FKSVDFNWLQAMVKK

ST3GAL5

266

Q9UNP4
QALLQSEKMLWQFLK

SEC31B

456

Q9NQW1
WKALSMNSGNAKEKS

SLC4A8

1076

Q2Y0W8
TILSDWTNSNKQKMK

BIRC2

26

Q13490
WNKILSYKIGKEMQN

CAPZA2

271

P47755
NGKWMQISKLQSQRK

ANKFN1

561

Q8N957
YKEWKSQVQSGMRNK

TP53TG5

126

Q9Y2B4
KDQLNMAKNTWPILK

INPP5J

631

Q15735
TFWAQSINRNKDIMK

STK31

46

Q9BXU1
KSKQKLGAFLWMQRN

TCEAL4

171

Q96EI5
EMKNKVWNVSLKTFV

TRIM7

306

Q9C029
KNLSFMDAMNKFKWT

MOXD1

516

Q6UVY6
QLRKEQTKLKWMQSE

MIX23

101

Q4VC31
ALWTMNLQRQKSLKA

STON1

581

Q9Y6Q2
SWLNSKMNAQNKLSL

HSPA4L

746

O95757
KGKDWQMLAQKNSIN

UNC5D

871

Q6UXZ4
KSLKMTDAQVKTWFQ

TLX3

201

O43711
KKWFEKMQAGQISVQ

ZEB1

626

P37275
KALKMTDAQVKTWFQ

TLX1

236

P31314
FLLQAQTENIKKTWM

PLEKHG7

646

Q6ZR37
SMQKSVQNKIKSLNW

PSMG2

146

Q969U7
AKGAQWMKQIVSFDK

TBX1

201

O43435
WMKQIVSFDKLKLTN

TBX1

206

O43435
MSALKVNKNNAKLWN

TMTC3

436

Q6ZXV5
TKWENNNKALLQMAE

TXLNG

401

Q9NUQ3
SASKKWQQKEQQVMK

ZFC3H1

381

O60293
KNRMKKTDWLFLNAC

ZRANB1

256

Q9UGI0
VMFPVNSKKTSKLWN

ZBED4

551

O75132
WLQVASMNQKRSNFK

KLHL42

281

Q9P2K6