Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	potassium:chloride symporter activity	SLC12A2 SLC12A3 SLC12A5	8.31e-06	9	94	3	GO:0015379
GeneOntologyMolecularFunction	sodium:potassium:chloride symporter activity	SLC12A2 SLC12A3	6.56e-05	3	94	2	GO:0008511
GeneOntologyMolecularFunction	potassium:sodium symporter activity	SLC12A2 SLC12A3	6.56e-05	3	94	2	GO:0009674
GeneOntologyMolecularFunction	chloride:monoatomic cation symporter activity	SLC12A2 SLC12A3 SLC12A5	1.67e-04	23	94	3	GO:0015377
GeneOntologyMolecularFunction	monoatomic anion:monoatomic cation symporter activity	SLC12A2 SLC12A3 SLC12A5	2.43e-04	26	94	3	GO:0015296
GeneOntologyMolecularFunction	dihydropyrimidinase activity	DPYSL3 CRMP1	3.25e-04	6	94	2	GO:0004157
GeneOntologyMolecularFunction	active transmembrane transporter activity	SLC8A3 ABCA1 SLC9C1 SLC12A2 SLC12A3 CLCN6 ABCA13 ATP6V0A2 SLC12A5	4.14e-04	477	94	9	GO:0022804
GeneOntologyMolecularFunction	lipase binding	LRPAP1 APOB	4.53e-04	7	94	2	GO:0035473
GeneOntologyBiologicalProcess	regulation of cellular component size	NEFL WDR36 SLC12A2 SLC12A3 CLCN6 SPTA1 SPTBN2 TRIOBP MACF1 SIN3A CDH1 SLC12A5 MTPN	6.02e-08	426	93	13	GO:0032535
GeneOntologyBiologicalProcess	regulation of anatomical structure size	NEFL WDR36 SLC12A2 SLC12A3 CLCN6 SPTA1 SPTBN2 TRIOBP MACF1 SIN3A CDH1 ITGB1 SLC12A5 MTPN	6.80e-07	618	93	14	GO:0090066
GeneOntologyBiologicalProcess	regulation of cell size	WDR36 SLC12A2 SLC12A3 CLCN6 MACF1 SIN3A CDH1 SLC12A5 MTPN	8.10e-07	225	93	9	GO:0008361
GeneOntologyBiologicalProcess	cell volume homeostasis	SLC12A2 SLC12A3 CLCN6 SLC12A5	3.80e-05	42	93	4	GO:0006884
GeneOntologyBiologicalProcess	neuron projection development	NEFL DPYSL3 WDR36 RASGRF1 TRIO KALRN MYCBP2 AFG3L2 TRIOBP RRN3P2 MACF1 SIN3A CDH1 ITGB1 CRMP1 SLC12A5 ITPR1	5.46e-05	1285	93	17	GO:0031175
GeneOntologyBiologicalProcess	actin filament capping	SPTA1 SPTBN2 TRIOBP MTPN	5.47e-05	46	93	4	GO:0051693
GeneOntologyBiologicalProcess	import into cell	PIKFYVE ANKRD13A MRC1 SLC8A3 ABCA1 SLC9C1 SLC12A2 SLC12A3 ABCA13 WASF2 LRPAP1 ARHGAP25 ITGB1 LYST SLC12A5	8.73e-05	1074	93	15	GO:0098657
GeneOntologyBiologicalProcess	negative regulation of actin filament depolymerization	SPTA1 SPTBN2 TRIOBP MTPN	8.88e-05	52	93	4	GO:0030835
GeneOntologyBiologicalProcess	negative regulation of cellular component organization	ANKRD13A DPYSL3 WASF2 SPTA1 SPTBN2 TRIOBP LRPAP1 CDH1 ITGB1 PCID2 CRMP1 DNMT3L MTPN	1.31e-04	864	93	13	GO:0051129
GeneOntologyBiologicalProcess	regulation of actin filament depolymerization	SPTA1 SPTBN2 TRIOBP MTPN	1.66e-04	61	93	4	GO:0030834
GeneOntologyBiologicalProcess	mitochondrial calcium ion transmembrane transport	SLC8A3 AFG3L2 ITPR1	1.90e-04	25	93	3	GO:0006851
GeneOntologyBiologicalProcess	chloride ion homeostasis	SLC12A2 SLC12A3 SLC12A5	1.90e-04	25	93	3	GO:0055064
GeneOntologyBiologicalProcess	developmental growth	WDR36 SLC12A2 MYCBP2 SPTBN2 AFG3L2 MACF1 SIN3A COPS2 CDH1 ITGB1 UNC79 SLC12A5 MTPN	2.20e-04	911	93	13	GO:0048589
GeneOntologyBiologicalProcess	actin filament depolymerization	SPTA1 SPTBN2 TRIOBP MTPN	2.25e-04	66	93	4	GO:0030042
GeneOntologyBiologicalProcess	axonogenesis	NEFL WDR36 TRIO KALRN MYCBP2 AFG3L2 MACF1 SIN3A CDH1 ITGB1	2.34e-04	566	93	10	GO:0007409
GeneOntologyBiologicalProcess	synapse organization	NEFL SLC8A3 KALRN MYCBP2 WASF2 SPTBN2 AFG3L2 ADGRB2 CDH1 ITGB1 CRMP1	2.57e-04	685	93	11	GO:0050808
GeneOntologyBiologicalProcess	neuron development	NEFL DPYSL3 WDR36 RASGRF1 TRIO KALRN MYCBP2 AFG3L2 TRIOBP RRN3P2 MACF1 SIN3A CDH1 ITGB1 CRMP1 SLC12A5 ITPR1	2.63e-04	1463	93	17	GO:0048666
GeneOntologyBiologicalProcess	monoatomic anion homeostasis	SLC12A2 SLC12A3 SLC12A5	2.68e-04	28	93	3	GO:0055081
GeneOntologyBiologicalProcess	axon extension	WDR36 MACF1 SIN3A CDH1 ITGB1	3.65e-04	135	93	5	GO:0048675
GeneOntologyBiologicalProcess	negative regulation of actin filament polymerization	SPTA1 SPTBN2 TRIOBP MTPN	3.69e-04	75	93	4	GO:0030837
GeneOntologyBiologicalProcess	regulation of spontaneous synaptic transmission	SLC12A2 ITGB1	4.16e-04	7	93	2	GO:0150003
GeneOntologyBiologicalProcess	synaptic signaling	NEFL SLC8A3 SLC12A2 RASGRF1 TRIO SPTBN2 CADPS2 CDH1 ITGB1 UTRN RGS10 SLC12A5 ITPR1	4.26e-04	976	93	13	GO:0099536
GeneOntologyBiologicalProcess	regulation of neuron projection development	NEFL DPYSL3 KALRN MYCBP2 RRN3P2 MACF1 CDH1 ITGB1 CRMP1 ITPR1	4.35e-04	612	93	10	GO:0010975
GeneOntologyBiologicalProcess	inorganic ion import across plasma membrane	SLC8A3 SLC9C1 SLC12A2 SLC12A3 SLC12A5	4.61e-04	142	93	5	GO:0099587
GeneOntologyBiologicalProcess	inorganic cation import across plasma membrane	SLC8A3 SLC9C1 SLC12A2 SLC12A3 SLC12A5	4.61e-04	142	93	5	GO:0098659
GeneOntologyBiologicalProcess	actin filament organization	DPYSL3 WASF2 SPTA1 SPTBN2 ESPNL TRIOBP ARHGAP25 ITGB1 MTPN	4.85e-04	509	93	9	GO:0007015
GeneOntologyBiologicalProcess	cell morphogenesis involved in neuron differentiation	NEFL WDR36 TRIO KALRN MYCBP2 AFG3L2 TRIOBP MACF1 SIN3A CDH1 ITGB1	5.41e-04	748	93	11	GO:0048667
GeneOntologyBiologicalProcess	pyrimidine nucleobase catabolic process	DPYSL3 CRMP1	5.53e-04	8	93	2	GO:0006208
GeneOntologyBiologicalProcess	import across plasma membrane	SLC8A3 SLC9C1 SLC12A2 SLC12A3 ITGB1 SLC12A5	6.12e-04	230	93	6	GO:0098739
GeneOntologyBiologicalProcess	potassium ion homeostasis	SLC12A2 SLC12A3 SLC12A5	6.17e-04	37	93	3	GO:0055075
GeneOntologyBiologicalProcess	axon development	NEFL WDR36 TRIO KALRN MYCBP2 AFG3L2 MACF1 SIN3A CDH1 ITGB1	6.30e-04	642	93	10	GO:0061564
GeneOntologyBiologicalProcess	potassium ion transmembrane transport	SLC9C1 SLC12A2 SLC12A3 KCNF1 ITGB1 SLC12A5	6.40e-04	232	93	6	GO:0071805
GeneOntologyBiologicalProcess	negative regulation of protein depolymerization	SPTA1 SPTBN2 TRIOBP MTPN	7.06e-04	89	93	4	GO:1901880
GeneOntologyCellularComponent	postsynapse	NEFL SLC8A3 TRIO KALRN SPTBN2 MACF1 CADPS2 CDH1 ITGB1 UTRN RGS10 CRMP1 SLC12A5 ITPR1	1.98e-04	1018	95	14	GO:0098794
GeneOntologyCellularComponent	actin cytoskeleton	DPYSL3 KALRN WASF2 SPTA1 SPTBN2 TRIOBP MACF1 CDH1 CRMP1 MTPN	2.89e-04	576	95	10	GO:0015629
GeneOntologyCellularComponent	cell body	DPYSL3 SLC8A3 SLC12A2 RASGRF1 KALRN SPTBN2 APOB WDFY3 TOP1 RGS10 CRMP1 SLC12A5 ITPR1	2.89e-04	929	95	13	GO:0044297
GeneOntologyCellularComponent	neuronal cell body	SLC8A3 SLC12A2 RASGRF1 KALRN SPTBN2 APOB WDFY3 TOP1 RGS10 CRMP1 SLC12A5 ITPR1	3.97e-04	835	95	12	GO:0043025
GeneOntologyCellularComponent	spectrin-associated cytoskeleton	SPTA1 SPTBN2	7.21e-04	9	95	2	GO:0014731
GeneOntologyCellularComponent	spectrin	SPTA1 SPTBN2	7.21e-04	9	95	2	GO:0008091
MousePheno	absent blastocoele	PIKFYVE WDR36 CDH1 ITGB1	2.93e-05	33	76	4	MP:0002663
MousePheno	abnormal blastocoele morphology	PIKFYVE WDR36 CDH1 ITGB1	4.16e-05	36	76	4	MP:0004963
MousePheno	abnormal brain interneuron morphology	MYCBP2 LRPAP1 CADPS2 SLC12A5	4.65e-05	37	76	4	MP:0004101
Domain	Spectrin	TRIO KALRN SPTA1 SPTBN2 MACF1 UTRN	1.07e-09	23	91	6	PF00435
Domain	Spectrin_repeat	TRIO KALRN SPTA1 SPTBN2 MACF1 UTRN	4.91e-09	29	91	6	IPR002017
Domain	Spectrin/alpha-actinin	TRIO KALRN SPTA1 SPTBN2 MACF1 UTRN	9.26e-09	32	91	6	IPR018159
Domain	SPEC	TRIO KALRN SPTA1 SPTBN2 MACF1 UTRN	9.26e-09	32	91	6	SM00150
Domain	SLC12A_fam	SLC12A2 SLC12A3 SLC12A5	3.86e-06	7	91	3	IPR004842
Domain	SLC12_C	SLC12A2 SLC12A3 SLC12A5	6.16e-06	8	91	3	IPR018491
Domain	SLC12	SLC12A2 SLC12A3 SLC12A5	6.16e-06	8	91	3	PF03522
Domain	Fam133	FAM133B FAM133A	2.35e-05	2	91	2	IPR026766
Domain	AA_permease_N	SLC12A2 SLC12A3	7.02e-05	3	91	2	IPR013612
Domain	AA_permease_N	SLC12A2 SLC12A3	7.02e-05	3	91	2	PF08403
Domain	PCI_dom	COPS2 PCID2 EIF3CL	7.24e-05	17	91	3	IPR000717
Domain	PCI	COPS2 PCID2 EIF3CL	7.24e-05	17	91	3	PF01399
Domain	PH	RASGRF1 TRIO KALRN SPTBN2 TRIOBP ARHGAP25 CADPS2	1.28e-04	229	91	7	PF00169
Domain	AA-permease/SLC12A_dom	SLC12A2 SLC12A3 SLC12A5	1.61e-04	22	91	3	IPR004841
Domain	AA_permease	SLC12A2 SLC12A3 SLC12A5	1.61e-04	22	91	3	PF00324
Domain	Actinin_actin-bd_CS	SPTBN2 MACF1 UTRN	1.85e-04	23	91	3	IPR001589
Domain	ACTININ_2	SPTBN2 MACF1 UTRN	1.85e-04	23	91	3	PS00020
Domain	ACTININ_1	SPTBN2 MACF1 UTRN	1.85e-04	23	91	3	PS00019
Domain	PH_dom-like	RASGRF1 TRIO KALRN SPTBN2 TRIOBP ARHGAP25 WDFY3 CADPS2 LYST	2.31e-04	426	91	9	IPR011993
Domain	Hydantoinase/dihydroPyrase	DPYSL3 CRMP1	3.48e-04	6	91	2	IPR011778
Domain	PH_BEACH	WDFY3 LYST	3.48e-04	6	91	2	PF14844
Domain	PH	RASGRF1 TRIO KALRN SPTBN2 TRIOBP ARHGAP25 CADPS2	4.19e-04	278	91	7	SM00233
Domain	PH_DOMAIN	RASGRF1 TRIO KALRN SPTBN2 TRIOBP ARHGAP25 CADPS2	4.28e-04	279	91	7	PS50003
Domain	PH_domain	RASGRF1 TRIO KALRN SPTBN2 TRIOBP ARHGAP25 CADPS2	4.37e-04	280	91	7	IPR001849
Domain	PH-BEACH_dom	WDFY3 LYST	6.45e-04	8	91	2	IPR023362
Domain	-	WDFY3 LYST	6.45e-04	8	91	2	2.30.29.40
Domain	-	DPYSL3 CRMP1	6.45e-04	8	91	2	2.30.40.10
Domain	PH_BEACH	WDFY3 LYST	6.45e-04	8	91	2	PS51783
Domain	Znf_FYVE_PHD	PIKFYVE ZMYND11 DIDO1 WDFY3 DNMT3L	7.62e-04	147	91	5	IPR011011
Domain	BEACH_dom	WDFY3 LYST	8.27e-04	9	91	2	IPR000409
Domain	PH_dom-spectrin-type	SPTBN2 ARHGAP25	8.27e-04	9	91	2	IPR001605
Domain	BEACH	WDFY3 LYST	8.27e-04	9	91	2	PS50197
Domain	Beach	WDFY3 LYST	8.27e-04	9	91	2	PF02138
Domain	-	WDFY3 LYST	8.27e-04	9	91	2	1.10.1540.10
Domain	Beach	WDFY3 LYST	8.27e-04	9	91	2	SM01026
Domain	Amidohydro_1	DPYSL3 CRMP1	1.03e-03	10	91	2	PF01979
Domain	Metal-dep_hydrolase_composite	DPYSL3 CRMP1	1.03e-03	10	91	2	IPR011059
Domain	Amidohydro-rel	DPYSL3 CRMP1	1.25e-03	11	91	2	IPR006680
Domain	ARM-type_fold	USP34 KPNA7 APOB WDFY3 LYST UNC79 ITPR1	1.34e-03	339	91	7	IPR016024
Domain	ABC_A	ABCA1 ABCA13	1.50e-03	12	91	2	IPR026082
Domain	PINT	COPS2 EIF3CL	2.70e-03	16	91	2	SM00088
Domain	-	RASGRF1 TRIO KALRN SPTBN2 TRIOBP ARHGAP25 CADPS2	2.99e-03	391	91	7	2.30.29.30
Domain	WD40_repeat_dom	WDR36 CFAP52 WDR87 PAN2 WDFY3 LYST	3.31e-03	297	91	6	IPR017986
Domain	DH_1	RASGRF1 TRIO KALRN	3.60e-03	63	91	3	PS00741
Domain	CH	SPTBN2 MACF1 UTRN	3.93e-03	65	91	3	SM00033
Domain	RCC1	FBXO24 MYCBP2	4.21e-03	20	91	2	PF00415
Domain	RhoGEF	RASGRF1 TRIO KALRN	4.46e-03	68	91	3	SM00325
Domain	RCC1_1	FBXO24 MYCBP2	4.64e-03	21	91	2	PS00625
Domain	RCC1_2	FBXO24 MYCBP2	4.64e-03	21	91	2	PS00626
Domain	CRAL_TRIO	TRIO KALRN	4.64e-03	21	91	2	PF00650
Domain	RCC1_3	FBXO24 MYCBP2	4.64e-03	21	91	2	PS50012
Domain	RhoGEF	RASGRF1 TRIO KALRN	4.84e-03	70	91	3	PF00621
Domain	CH	SPTBN2 MACF1 UTRN	4.84e-03	70	91	3	PF00307
Domain	DH_2	RASGRF1 TRIO KALRN	4.84e-03	70	91	3	PS50010
Pathway	REACTOME_CATION_COUPLED_CHLORIDE_COTRANSPORTERS	SLC12A2 SLC12A3 SLC12A5	4.41e-06	7	72	3	M27339
Pathway	REACTOME_CATION_COUPLED_CHLORIDE_COTRANSPORTERS	SLC12A2 SLC12A3 SLC12A5	4.41e-06	7	72	3	MM15081
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	USP34 RNMT PAN2 MACF1 DIDO1 CEP295 APOB ANKRD12 COPS2 CDH1 ITGB1 ME2 UTRN PAICS CRMP1 ATP6V0A2 ITPR1 MTPN	9.26e-10	1084	96	18	11544199
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	NEFL TRIO KALRN MYCBP2 WASF2 SPTBN2 SUPT16H ADGRB2 TRIOBP MACF1 DIDO1 WDFY3 UNC79 CEP170B CRMP1 SLC12A5	8.81e-09	963	96	16	28671696
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	USP34 NEFL OXR1 TRIO KALRN MYCBP2 SPTBN2 TRIOBP MACF1 LRPAP1 WDFY3 CADPS2 UTRN TOP1 PAICS CRMP1 MTPN	7.94e-08	1285	96	17	35914814
Pubmed	Reactive astrogliosis causes the development of spontaneous seizures.	SLC12A2 ITGB1 SLC12A5	4.05e-07	6	96	3	25716834
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	ZNF131 PDE3B WDR36 SLC12A2 MYCBP2 SPTBN2 AFG3L2 SUPT16H TRIOBP MACF1 LRPAP1 MRPL46 ITGB1 ME2 ATP6V0A2 ITPR1 MTPN	6.17e-07	1487	96	17	33957083
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	FBXO24 MYOM1 RASGRF1 MYCBP2 ABCA13 MACF1 DIDO1 CADPS2 TOP1	7.42e-07	361	96	9	26167880
Pubmed	Similar effects of all WNK3 variants on SLC12 cotransporters.	SLC12A2 SLC12A3 SLC12A5	1.13e-06	8	96	3	21613606
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	NEFL TRIO KALRN SPTBN2 ADGRB2 MACF1 CEP170B CRMP1	1.18e-06	281	96	8	28706196
Pubmed	Cation-chloride cotransporters and neuronal function.	SLC12A2 SLC12A3 SLC12A5	1.69e-06	9	96	3	19323993
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	NEFL DPYSL3 CLCN6 OXR1 TRIO KALRN SPTA1 SPTBN2 AFG3L2 MACF1 UTRN TOP1 CEP170B CRMP1 EIF3CL SLC12A5	1.84e-06	1431	96	16	37142655
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	USP34 NEFL WDR36 MYCBP2 SPTBN2 MACF1 DIDO1 ME2 UTRN TOP1 PAICS	1.96e-06	653	96	11	22586326
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	USP34 CLCN6 MYCBP2 ERAP1 TRIOBP MACF1 WDFY3	3.16e-06	225	96	7	12168954
Pubmed	Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia.	DPYSL3 TRIO KALRN MACF1 CEP295 UTRN	4.07e-06	151	96	6	17043677
Pubmed	Abnormal expression of cerebrospinal fluid cation chloride cotransporters in patients with Rett syndrome.	SLC12A2 SLC12A5	7.54e-06	2	96	2	23894354
Pubmed	Integrin β1 orchestrates the abnormal cell-matrix attachment and invasive behaviour of E-cadherin dysfunctional cells.	CDH1 ITGB1	7.54e-06	2	96	2	34486077
Pubmed	Spectrin tethers and mesh in the biosynthetic pathway.	SPTA1 SPTBN2	7.54e-06	2	96	2	10852813
Pubmed	NKCC1 and KCC2 prevent hyperexcitability in the mouse hippocampus.	SLC12A2 SLC12A5	7.54e-06	2	96	2	18394864
Pubmed	Homing of mouse spermatogonial stem cells to germline niche depends on beta1-integrin.	CDH1 ITGB1	7.54e-06	2	96	2	18983968
Pubmed	KCC2 expression supersedes NKCC1 in mature fiber cells in mouse and rabbit lenses.	SLC12A2 SLC12A5	7.54e-06	2	96	2	26539026
Pubmed	NKCC1 transporter facilitates seizures in the developing brain.	SLC12A2 SLC12A5	7.54e-06	2	96	2	16227993
Pubmed	Hepatic ABCA1 deficiency is associated with delayed apolipoprotein B secretory trafficking and augmented VLDL triglyceride secretion.	ABCA1 APOB	7.54e-06	2	96	2	28694219
Pubmed	The chloride co-transporters, NKCC1 and KCC2, in experimental autoimmune encephalomyelitis (EAE).	SLC12A2 SLC12A5	7.54e-06	2	96	2	28057537
Pubmed	The structural basis of function and regulation of neuronal cotransporters NKCC1 and KCC2.	SLC12A2 SLC12A5	7.54e-06	2	96	2	33597714
Pubmed	Repeated stress-induced expression pattern alterations of the hippocampal chloride transporters KCC2 and NKCC1 associated with behavioral abnormalities in female mice.	SLC12A2 SLC12A5	7.54e-06	2	96	2	26239662
Pubmed	NKCC1 cotransporter inactivation underlies embryonic development of chloride-mediated inhibition in mouse spinal motoneuron.	SLC12A2 SLC12A5	7.54e-06	2	96	2	18096599
Pubmed	Reversing excitatory GABAAR signaling restores synaptic plasticity and memory in a mouse model of Down syndrome.	SLC12A2 SLC12A5	7.54e-06	2	96	2	25774849
Pubmed	Down-regulation of epithelial cadherin is required to initiate metastatic outgrowth of breast cancer.	CDH1 ITGB1	7.54e-06	2	96	2	21613543
Pubmed	Long-term expressional changes of Na+ -K+ -Cl- co-transporter 1 (NKCC1) and K+ -Cl- co-transporter 2 (KCC2) in CA1 region of hippocampus following lithium-pilocarpine induced status epilepticus (PISE).	SLC12A2 SLC12A5	7.54e-06	2	96	2	18550034
Pubmed	[Expression of cation chloride cotransporter (NKCC1/KCC2) in brain tissue of children with focal cortical dysplasia type Ⅱ].	SLC12A2 SLC12A5	7.54e-06	2	96	2	36323541
Pubmed	Kalirin and Trio proteins serve critical roles in excitatory synaptic transmission and LTP.	TRIO KALRN	7.54e-06	2	96	2	26858404
Pubmed	Fibrillar collagen type I stimulation of apolipoprotein B secretion in Caco-2 cells is mediated by beta1 integrin.	APOB ITGB1	7.54e-06	2	96	2	19646550
Pubmed	CRMP1 and CRMP4 are required for proper orientation of dendrites of cerebral pyramidal neurons in the developing mouse brain.	DPYSL3 CRMP1	7.54e-06	2	96	2	27836492
Pubmed	Axonal morphogenesis controlled by antagonistic roles of two CRMP subtypes in microtubule organization.	DPYSL3 CRMP1	7.54e-06	2	96	2	12814366
Pubmed	Opposite effect of membrane raft perturbation on transport activity of KCC2 and NKCC1.	SLC12A2 SLC12A5	7.54e-06	2	96	2	19686239
Pubmed	NKCC1 to KCC2 mRNA Ratio in Schizophrenia and Its Psychopathology: a Case-Control Study.	SLC12A2 SLC12A5	7.54e-06	2	96	2	35624355
Pubmed	[Expression of E-cadherin and beta1-integrin mRNA in endometrial cancer].	CDH1 ITGB1	7.54e-06	2	96	2	24455846
Pubmed	Directional ABCA1-mediated cholesterol efflux and apoB-lipoprotein secretion in the retinal pigment epithelium.	ABCA1 APOB	7.54e-06	2	96	2	30076206
Pubmed	Aberrant expression of E-cadherin and integrin β-1 in trophoblasts is associated with malignant gestational trophoblastic diseases.	CDH1 ITGB1	7.54e-06	2	96	2	23455756
Pubmed	Role of NKCC1 and KCC2 during hypoxia-induced neuronal swelling in the neonatal neocortex.	SLC12A2 SLC12A5	7.54e-06	2	96	2	36706928
Pubmed	CRMP1 Interacted with Spy1 During the Collapse of Growth Cones Induced by Sema3A and Acted on Regeneration After Sciatic Nerve Crush.	SPDYA CRMP1	7.54e-06	2	96	2	25526860
Pubmed	Expression changes of K+-Cl- co-transporter 2 and Na+-K+-Cl- co-transporter1 in mouse trigeminal subnucleus caudalis following pulpal inflammation.	SLC12A2 SLC12A5	7.54e-06	2	96	2	20067823
Pubmed	Methylation of cation-chloride cotransporters NKCC1 and KCC2 in patients with juvenile myoclonic epilepsy.	SLC12A2 SLC12A5	7.54e-06	2	96	2	30759289
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	NEFL RNMT KALRN MYCBP2 SPTBN2 SUPT16H PAN2 TRIOBP MACF1 DIDO1 MRPL46 TOP1 CRMP1	8.82e-06	1082	96	13	38697112
Pubmed	Epithelial-Macrophage Crosstalk Initiates Sterile Inflammation in Embryonic Skin.	MRC1 CDH1 ITGB1	9.05e-06	15	96	3	34721382
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	MYOM1 TRIO KALRN MYCBP2 AFG3L2 SUPT16H MACF1 ITGB1 UTRN	9.98e-06	497	96	9	23414517
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	ZNF131 DPYSL3 WDR36 WASF2 AFG3L2 MACF1 DIDO1 SIN3A ME2 UTRN TOP1 MTPN	1.04e-05	934	96	12	33916271
Pubmed	Rac1 GTPase-deficient mouse lens exhibits defects in shape, suture formation, fiber cell migration and survival.	WASF2 CDH1 ITGB1	1.11e-05	16	96	3	21945075
Pubmed	De novo point mutations in patients diagnosed with ataxic cerebral palsy.	SPTBN2 ITPR1	2.26e-05	3	96	2	25981959
Pubmed	Synaptic Kalirin-7 and Trio Interactomes Reveal a GEF Protein-Dependent Neuroligin-1 Mechanism of Action.	TRIO KALRN	2.26e-05	3	96	2	31801062
Pubmed	E-cadherin is a ligand for integrin alpha2beta1.	CDH1 ITGB1	2.26e-05	3	96	2	12392763
Pubmed	Recently reported familial hypercholesterolemia-related mutations from cases in the Middle East and North Africa region.	ABCA1 APOB	2.26e-05	3	96	2	30694837
Pubmed	Integrin-mediated functional polarization of Caco-2 cells through E-cadherin--actin complexes.	CDH1 ITGB1	2.26e-05	3	96	2	11861761
Pubmed	Protein phosphorylation and expression profiling by Yin-yang multidimensional liquid chromatography (Yin-yang MDLC) mass spectrometry.	USP34 GVINP1	2.26e-05	3	96	2	17203969
Pubmed	CD93 promotes β1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis.	MMRN2 ITGB1	2.26e-05	3	96	2	29763414
Pubmed	Networks of E-cadherin, β1 integrin, and focal adhesion kinase in the pathogenesis of tubal pregnancy.	CDH1 ITGB1	2.26e-05	3	96	2	30430889
Pubmed	Apolipoprotein A-1 binding protein promotes macrophage cholesterol efflux by facilitating apolipoprotein A-1 binding to ABCA1 and preventing ABCA1 degradation.	ABCA1 COPS2	2.26e-05	3	96	2	27017521
Pubmed	The WAVE2/miR-29/Integrin-β1 Oncogenic Signaling Axis Promotes Tumor Growth and Metastasis in Triple-negative Breast Cancer.	WASF2 ITGB1	2.26e-05	3	96	2	36968231
Pubmed	The highly conserved region of the co-repressor Sin3A functionally interacts with the co-repressor Alien.	SIN3A COPS2	2.26e-05	3	96	2	15173382
Pubmed	Ripply3 is required for the maintenance of epithelial sheets in the morphogenesis of pharyngeal pouches.	CDH1 ITGB1	2.26e-05	3	96	2	29471585
Pubmed	Aberrant expression of Pax-2 in Danforth's short tail (Sd) mice.	NEFL CDH1	2.26e-05	3	96	2	8482415
Pubmed	The COP9 signalosome controls ubiquitinylation of ABCA1.	ABCA1 COPS2	2.26e-05	3	96	2	19268428
Pubmed	Mesothelial cells interact with tumor cells for the formation of ovarian cancer multicellular spheroids in peritoneal effusions.	CDH1 ITGB1	2.26e-05	3	96	2	27612856
Pubmed	Prognostic role of integrin β1, E-cadherin, and rac1 expression in small cell lung cancer.	CDH1 ITGB1	2.26e-05	3	96	2	22151306
Pubmed	Relaxation of synaptic inhibitory events as a compensatory mechanism in fetal SOD spinal motor networks.	SLC12A2 SLC12A5	2.26e-05	3	96	2	31868588
Pubmed	Cell-extracellular matrix versus cell-cell interactions during the development of the cochlear-vestibular ganglion.	CDH1 ITGB1	2.26e-05	3	96	2	21557292
Pubmed	ATG5 is required for B cell polarization and presentation of particulate antigens.	FAM133B FAM133A WASF2 SUPT16H TRIOBP TOP1 PAICS PCID2 EIF3CL ITPR1	2.47e-05	701	96	10	30196744
Pubmed	Rare independent mutations in renal salt handling genes contribute to blood pressure variation.	SLC12A2 SLC12A3 SLC12A5	3.02e-05	22	96	3	18391953
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	NEFL DPYSL3 SLC12A2 TRIO MYCBP2 SPTBN2 AFG3L2 SUPT16H TRIOBP ITGB1 UTRN ITPR1	3.24e-05	1049	96	12	27880917
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	FAM133B NEFL FAM133A SPTA1 SPTBN2 SUPT16H MACF1 CEP295 APOB CADPS2 CDH1 LYST TOP1 PCID2	4.15e-05	1442	96	14	35575683
Pubmed	A novel function of apolipoprotein E: upregulation of ATP-binding cassette transporter A1 expression.	ABCA1 APOB	4.51e-05	4	96	2	21779326
Pubmed	Impaired phosphorylation of Na(+)-K(+)-2Cl(-) cotransporter by oxidative stress-responsive kinase-1 deficiency manifests hypotension and Bartter-like syndrome.	SLC12A2 SLC12A3	4.51e-05	4	96	2	21972418
Pubmed	Integrin-linked kinase and ELMO2 modulate recycling endosomes in keratinocytes.	CDH1 ITGB1	4.51e-05	4	96	2	27627840
Pubmed	Epigenetic repression of E-cadherin expression by hepatitis B virus x antigen in liver cancer.	SIN3A CDH1	4.51e-05	4	96	2	21706058
Pubmed	Differential expression of dihydropyrimidinase-related protein genes in developing and adult enteric nervous system.	DPYSL3 CRMP1	4.51e-05	4	96	2	10664068
Pubmed	RNA-binding protein is involved in aggregation of light neurofilament protein and is implicated in the pathogenesis of motor neuron degeneration.	NEFL RASGRF1	4.51e-05	4	96	2	16236762
Pubmed	Quantitative in vivo imaging of the effects of inhibiting integrin signaling via Src and FAK on cancer cell movement: effects on E-cadherin dynamics.	CDH1 ITGB1	4.51e-05	4	96	2	21045155
Pubmed	The Ulip family phosphoproteins--common and specific properties.	DPYSL3 CRMP1	4.51e-05	4	96	2	9652388
Pubmed	Apparent structural differences at the tetramerization region of erythroid and nonerythroid beta spectrin as discriminated by phage displayed scFvs.	SPTA1 SPTBN2	4.51e-05	4	96	2	21412925
Pubmed	Loss of miR-200b promotes invasion via activating the Kindlin-2/integrin β1/AKT pathway in esophageal squamous cell carcinoma: An E-cadherin-independent mechanism.	CDH1 ITGB1	4.51e-05	4	96	2	26334393
Pubmed	Amino- and carboxyl-terminal domains of Filamin-A interact with CRMP1 to mediate Sema3A signalling.	DPYSL3 CRMP1	4.51e-05	4	96	2	25358863
Pubmed	E-cadherin loss promotes the initiation of squamous cell carcinoma invasion through modulation of integrin-mediated adhesion.	CDH1 ITGB1	4.51e-05	4	96	2	16390868
Pubmed	Developmentally regulated KCC2 phosphorylation is essential for dynamic GABA-mediated inhibition and survival.	SLC12A2 SLC12A5	4.51e-05	4	96	2	31615901
Pubmed	Aberrant cell adhesion molecule expression in human bronchopulmonary sequestration and congenital cystic adenomatoid malformation.	CDH1 ITGB1	4.51e-05	4	96	2	19411307
Pubmed	The impact of APOA5, APOB, APOC3 and ABCA1 gene polymorphisms on ischemic stroke: Evidence from a meta-analysis.	ABCA1 APOB	4.51e-05	4	96	2	28865324
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	FAM133B WDR36 MYCBP2 SUPT16H MACF1 DIDO1 SIN3A MRPL46 TOP1 PCID2	4.81e-05	759	96	10	35915203
Pubmed	Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.	DPYSL3 OXR1 RASGRF1 MYCBP2 MACF1 CEP170B EIF3CL	5.16e-05	347	96	7	17114649
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	TRIO MYCBP2 ERAP1 AFG3L2 GBE1 MACF1 DIDO1 LRPAP1 APOB ITGB1 TOP1 PAICS PCID2	5.80e-05	1297	96	13	33545068
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	USP34 ZMYND11 AFG3L2 SUPT16H MACF1 C16orf96 CEP295 SIN3A WDFY3 TOP1 CEP170B PCID2	5.88e-05	1116	96	12	31753913
Pubmed	Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.	NEFL TRIO KALRN SPTBN2 ADGRB2 MACF1	7.17e-05	251	96	6	27507650
Pubmed	Pax6 is misexpressed in Sox1 null lens fiber cells.	CDH1 ITGB1	7.50e-05	5	96	2	17306631
Pubmed	RGS10 restricts upregulation by chemokines of T cell adhesion mediated by α4β1 and αLβ2 integrins.	ITGB1 RGS10	7.50e-05	5	96	2	21705617
Pubmed	Distinct priming kinases contribute to differential regulation of collapsin response mediator proteins by glycogen synthase kinase-3 in vivo.	DPYSL3 CRMP1	7.50e-05	5	96	2	16611631
Pubmed	Role of dystrophins and utrophins in platelet adhesion process.	ITGB1 UTRN	7.50e-05	5	96	2	16803572
Pubmed	Cytokine-Like Factor 1, an Essential Facilitator of Cardiotrophin-Like Cytokine:Ciliary Neurotrophic Factor Receptor α Signaling and sorLA-Mediated Turnover.	LRPAP1 CLCF1	7.50e-05	5	96	2	26858303
Pubmed	Assembly of high order G alpha q-effector complexes with RGS proteins.	TRIO KALRN	7.50e-05	5	96	2	18936096
Pubmed	A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution.	DPYSL3 CRMP1	7.50e-05	5	96	2	8973361
Pubmed	DOT1L regulates chamber-specific transcriptional networks during cardiogenesis and mediates postnatal cell cycle withdrawal.	NEFL MYOM1 CADPS2	7.84e-05	30	96	3	36460641
Pubmed	Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray.	ZNF131 ABCA1 WDR36 TRIOBP CDH1 PAICS ATP6V0A2	7.84e-05	371	96	7	15747579
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	SLC12A2 MYCBP2 SPTA1 MOV10L1 MACF1 UTRN UNC79 TOP1 PAICS MTPN	8.00e-05	807	96	10	30575818
Pubmed	WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl- cotransporters required for normal blood pressure homeostasis.	SLC12A3 CDH1	1.12e-04	6	96	2	16275913
GeneFamily	EF-hand domain containing\|Spectrins	SPTA1 SPTBN2	2.89e-04	7	68	2	1113
GeneFamily	WD repeat domain containing\|BEACH domain containing	WDFY3 LYST	4.93e-04	9	68	2	1230
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	RASGRF1 SPTBN2 TRIOBP ARHGAP25 CADPS2	1.07e-03	206	68	5	682
GeneFamily	ATP binding cassette subfamily A	ABCA1 ABCA13	1.23e-03	14	68	2	805
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	RASGRF1 TRIO KALRN	1.97e-03	66	68	3	722
GeneFamily	WD repeat domain containing	WDR36 CFAP52 WDR87 WDFY3 LYST	3.05e-03	262	68	5	362
Coexpression	GSE29618_BCELL_VS_PDC_UP	PIKFYVE GVINP1 TRIO MYCBP2 MACF1 ARHGAP25 LYST	7.44e-06	196	95	7	M4940
Coexpression	MURARO_PANCREAS_BETA_CELL	PIKFYVE USP34 ZMYND11 RNMT RASGRF1 MYCBP2 KLHDC8A PAN2 ANKRD12 COPS2 UTRN LYST UNC79 CRMP1	7.80e-06	946	95	14	M39169
Coexpression	GSE11057_EFF_MEM_VS_CENT_MEM_CD4_TCELL_DN	USP34 PDE3B KALRN MYCBP2 MACF1 CDH1	6.63e-05	189	95	6	M3112
Coexpression	GSE20727_CTRL_VS_H2O2_TREATED_DC_DN	MYCBP2 ARHGAP25 SIN3A CLCF1 UTRN LYST	8.10e-05	196	95	6	M9243
Coexpression	GSE22886_IGM_MEMORY_BCELL_VS_BLOOD_PLASMA_CELL_UP	RASGRF1 MMRN2 GCA MFSD13A UTRN LYST	8.57e-05	198	95	6	M4451
Coexpression	GSE40274_HELIOS_VS_FOXP3_AND_HELIOS_TRANSDUCED_ACTIVATED_CD4_TCELL_DN	DUSP12 PDE3B ENDOU ATP6V0A2 SLC12A5 ITPR1	8.81e-05	199	95	6	M9168
Coexpression	GSE37532_WT_VS_PPARG_KO_VISCERAL_ADIPOSE_TISSUE_TREG_DN	ABCA1 MYOM1 GCA CDH1 TOP1 RGS10	9.05e-05	200	95	6	M8962
Coexpression	GSE4748_CTRL_VS_LPS_AND_CYANOBACTERIUM_LPSLIKE_STIM_DC_3H_UP	DPYSL3 WDR36 OXR1 WASF2 SUPT16H PAICS	9.05e-05	200	95	6	M6484
Coexpression	GSE17721_LPS_VS_CPG_1H_BMDC_DN	KALRN SIN3A ITGB1 CLCF1 UTRN TOP1	9.05e-05	200	95	6	M3987
Coexpression	GSE21774_CD62L_POS_CD56_BRIGHT_VS_CD62L_NEG_CD56_DIM_NK_CELL_DN	MYOM1 SPTA1 PAN2 WDFY3 CADPS2 UTRN	9.05e-05	200	95	6	M7495
ToppCell	Hippocampus-Neuronal-Excitatory\|Hippocampus / BrainAtlas - Mouse McCarroll V32	NEFL ZMYND11 RASGRF1 KALRN KCNF1 ADGRB2 MTPN	1.80e-07	189	96	7	4b90d181eb0a42814eeb23bc82e52fd3a12392a7
ToppCell	droplet-Limb_Muscle-MUSCLE\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	USP34 WASF2 MACF1 ANKRD12 ITGB1 UTRN TOP1	2.14e-07	194	96	7	e3d63874111d1e8da3977329426e4dcf68d6de87
ToppCell	severe-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	FAM133B USP34 PDE3B RNMT MACF1 ANKRD12 UTRN	2.38e-07	197	96	7	57ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	FAM133B USP34 RNMT MYCBP2 MACF1 ANKRD12 UTRN	2.63e-07	200	96	7	12f1685ce8f218433068e090c9d839cd5a1910bf
ToppCell	10x5'-blood-Lymphocytic_T_CD4-T_CD4/CD8\|blood / Manually curated celltypes from each tissue	USP34 PDE3B MACF1 ANKRD12 UTRN ITPR1	1.41e-06	162	96	6	b4535bcb3f469bc139e73f1122f4070013e5a1de
ToppCell	3'_v3-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	FAM133B PDE3B MACF1 APOB ANKRD12 UTRN	1.93e-06	171	96	6	2e9a20f8980b78325c52065a9c14ab3656267c05
ToppCell	facs-Kidney-nan-3m-Epithelial-kidney_collecting_duct_principal_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC12A3 KALRN ABCA13 SPTBN2 GCA CDH1	2.59e-06	180	96	6	fc5b9d0e3215652e490ca72d69f776e9725608b2
ToppCell	facs-Kidney-nan-3m-Epithelial-kidney_collecting_duct_principal_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC12A3 KALRN ABCA13 SPTBN2 GCA CDH1	2.59e-06	180	96	6	6763b22f2383931c747b37cd0ae2f60b08f64d90
ToppCell	Posterior_cortex-Neuronal-Excitatory\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	NEFL KALRN KCNF1 SPTBN2 ADGRB2 MTPN	2.95e-06	184	96	6	25ccf08a8a26d7e7827b6357f33a53aaf423577d
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NEFL RASGRF1 KLHDC8A RGS10 CRMP1 SLC12A5	3.04e-06	185	96	6	70de48988c1f8e0809afc8092b663aa439d8e528
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal-Granular_Neuron_CB_Gabra6\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NEFL RASGRF1 KLHDC8A UNC79 RGS10 CRMP1	3.13e-06	186	96	6	d6c8ce2a32c218dcc63d861cc247152430ed3c8c
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	USP34 PDE3B MACF1 ANKRD12 UTRN ITPR1	3.33e-06	188	96	6	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	Globus_pallidus-Neuronal\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	RASGRF1 MYCBP2 SPTBN2 ANKRD12 CRMP1 SLC12A5	3.54e-06	190	96	6	416de85d8841dac883faa6f5339b2fb461a09e82
ToppCell	PND10\|World / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DPYSL3 ZMYND11 MYCBP2 MACF1 ITGB1 UTRN	3.54e-06	190	96	6	d67e2814047c8df2ae4b7bc8be9539f5df6ecef2
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASGRF1 KALRN KCNF1 SPTBN2 ADGRB2 SLC12A5	3.88e-06	193	96	6	be28070c049e7cb68bcd54f582226eb2f5e4bc1c
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASGRF1 KALRN KCNF1 SPTBN2 ADGRB2 SLC12A5	3.88e-06	193	96	6	0c652ebe22ce5d2927599dd97ef1920547858395
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASGRF1 KALRN KCNF1 SPTBN2 ADGRB2 SLC12A5	3.88e-06	193	96	6	8689a70a33a7c3823dc647d41ac0160e7c3ae396
ToppCell	mild-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	FAM133B USP34 PDE3B MACF1 ANKRD12 UTRN	4.62e-06	199	96	6	f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCell	COVID-19\|World / Disease, condition lineage and cell class	RNMT MYCBP2 MACF1 ANKRD12 UTRN TOP1	4.76e-06	200	96	6	7dec470c379cd89f05a0f37c8628b21f136e52f0
ToppCell	Severe-B_naive-5\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	MYOM1 CLCN6 SPDYA LYST PCID2	2.03e-05	153	96	5	44572f87d403e314050ab935d2cd676c33d9c287
ToppCell	Severe-B_naive-5\|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)	MYOM1 CLCN6 SPDYA LYST PCID2	2.30e-05	157	96	5	a57ee4a6febdff3ee3d1645836695e6e7c055cf8
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-lymphatic_endothelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MRC1 DPYSL3 KALRN SPTA1 MOV10L1	2.59e-05	161	96	5	fb59d96c2aa9e4654f02bf6ce36bf832776cb4dd
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MRC1 DPYSL3 KALRN SPTA1 MOV10L1	2.59e-05	161	96	5	c53c461fc721a7960cef86662f49e2a495520701
ToppCell	droplet-Marrow-BM_(NON-STC)-30m-Lymphocytic-plasma_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DUSP12 MRC1 DPYSL3 ABCA1 WDFY3	3.55e-05	172	96	5	7295bf3ae21a61dd6bcfa0dfb7a37d0f3e8f94ab
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	OXR1 ABCA13 WDFY3 UTRN CRMP1	3.97e-05	176	96	5	327a3e81b724252e36d786de92a3ffd721ea6d7b
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ANKRD13A PDE3B SPTBN2 CADPS2 ITPR1	4.30e-05	179	96	5	d3438fed0d85d5ed5afa8ff820c45143d77b6c0d
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NEFL ANKRD12 CADPS2 UNC79 SLC12A5	4.41e-05	180	96	5	f6a2208960d0df1500c974cc44c3c054cd7475a9
ToppCell	droplet-Liver-nan-3m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DPYSL3 KALRN MMRN2 ENDOU CADPS2	4.53e-05	181	96	5	fcc94f04dae98b817ec06b282d2e887804d37ae5
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	OXR1 ABCA13 WDFY3 UTRN CRMP1	4.53e-05	181	96	5	071f9bb5d39070cdc473d9b0e094d196bc702b56
ToppCell	droplet-Marrow-nan-3m-Hematologic-nan\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYCBP2 MACF1 ITGB1 UTRN LYST	4.65e-05	182	96	5	e78ba2c5cae480c16a596ce7c3bf2d480becacf4
ToppCell	droplet-Marrow-nan-3m-Hematologic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYCBP2 MACF1 ITGB1 UTRN LYST	4.65e-05	182	96	5	1710eab3037a87609d21838be2d2d29c3bc36651
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KALRN ABCA13 SPTA1 APOB UNC79	4.90e-05	184	96	5	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	Frontal_cortex-Neuronal-Excitatory\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	NEFL KALRN MYCBP2 ADGRB2 MTPN	4.90e-05	184	96	5	6e17c8151d6dc543de16d804db956c63c3fda414
ToppCell	droplet-Marrow-nan-3m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYCBP2 WASF2 MACF1 UTRN LYST	4.90e-05	184	96	5	1154a5ad7b8512272b7476f949ddac350910bfb7
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KALRN ABCA13 SPTA1 APOB UNC79	4.90e-05	184	96	5	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KALRN ABCA13 SPTA1 APOB UNC79	4.90e-05	184	96	5	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	droplet-Fat-Scat-21m-Epithelial\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLB1 SLC12A2 RASGRF1 SPTBN2 CDH1	5.16e-05	186	96	5	59710cff3f6f7c318ee2524b44c1a909f312c25e
ToppCell	droplet-Fat-Scat-21m-Epithelial-epithelial_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLB1 SLC12A2 RASGRF1 SPTBN2 CDH1	5.16e-05	186	96	5	de88fafac51049ec1920695844d8ce8057940272
ToppCell	facs-Brain_Non-Myeloid-Striatum_-18m-Neuronal-interneuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPTBN2 ANKRD12 CADPS2 UNC79 ITPR1	5.16e-05	186	96	5	a1ab273b01971d6a892912560d387685dd657179
ToppCell	Substantia_nigra-Neuronal\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	MYCBP2 SPTBN2 UNC79 CRMP1 SLC12A5	5.16e-05	186	96	5	3f889083fcffe516388e9b03a5e23af2010ced33
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KALRN KCNF1 SPTBN2 ADGRB2 SLC12A5	5.16e-05	186	96	5	7278a1a1bf9bb27aeb03852134defb31b62f30d6
ToppCell	droplet-Fat-Scat-21m-Epithelial-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLB1 SLC12A2 RASGRF1 SPTBN2 CDH1	5.16e-05	186	96	5	7ff73ab8fed5da779ee9c7bd2e14a8363edb7509
ToppCell	droplet-Bladder-nan\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF131 MYCBP2 WASF2 ANKRD12 TOP1	5.29e-05	187	96	5	663991a8afe652e92363b64bcbd68c14d0307f0e
ToppCell	facs-Brain_Non-Myeloid-Striatum_-18m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPTBN2 ANKRD12 CADPS2 UNC79 ITPR1	5.29e-05	187	96	5	ef3c85c01bc3da408ae288b6e3096ad888a12e63
ToppCell	Cerebellum-Neuronal\|Cerebellum / BrainAtlas - Mouse McCarroll V32	NEFL ANKRD12 UNC79 CRMP1 SLC12A5	5.29e-05	187	96	5	61b9d6eb131a674598aa8409d7fa909c8765442d
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NEFL RASGRF1 KLHDC8A UNC79 SLC12A5	5.29e-05	187	96	5	7b2cd0c618ed081223343f3bec2244c8723c9a31
ToppCell	droplet-Marrow-nan-3m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA13 GCA ANKRD12 MFSD13A LYST	5.29e-05	187	96	5	14c239af77116d28d511dea754b6150d20488080
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NEFL RASGRF1 SPTBN2 SLC12A5 ITPR1	5.43e-05	188	96	5	1efbc99bcd6542e5d9fa91edb7c4295167914786
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	OXR1 TRIO ABCA13 UTRN CRMP1	5.43e-05	188	96	5	63a4b25a0a6e05f80f1a6dd91b817f3cf49e6b68
ToppCell	facs-Brain_Myeloid-Striatum-3m-Myeloid-nan\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA1 PDE3B WASF2 MACF1 ITGB1	5.56e-05	189	96	5	6dd4ec5ce4beb856f0d2d1654e3c4676d1d63736
ToppCell	facs-Brain_Non-Myeloid-Striatum_-18m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPTBN2 ANKRD12 CADPS2 UNC79 ITPR1	5.56e-05	189	96	5	3d838da870623a6a278ddc8e6cedca85d9877e50
ToppCell	renal_medulla_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	OXR1 WDFY3 CADPS2 UTRN CRMP1	5.56e-05	189	96	5	830d9cd0dd706bce22eb2416f07b2c31c870a05a
ToppCell	facs-Brain_Myeloid-Striatum-3m-Myeloid\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA1 PDE3B WASF2 MACF1 ITGB1	5.56e-05	189	96	5	3ae479ec7e00c57127cbe51a398329b10ca9848c
ToppCell	facs-Brain_Myeloid-Striatum-3m-Myeloid-microglial_cell\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA1 PDE3B WASF2 MACF1 ITGB1	5.56e-05	189	96	5	875df61ee48baa5142ba4d2427bdec1c53e5a828
ToppCell	facs-Brain_Myeloid-Striatum-3m\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA1 PDE3B WASF2 MACF1 ITGB1	5.56e-05	189	96	5	97ef5215d841ff366a3e3682cd9bd04100cbfde0
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NEFL KALRN ADGRB2 CADPS2 ITPR1	5.70e-05	190	96	5	d594da827e3c16644952b9589cc12b947ce36279
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	USP34 WASF2 APOB CDH1 ITGB1	5.85e-05	191	96	5	60c986d2dcbc19d9338c03da6cb5e1d92fd48f8e
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MRC1 PLB1 ABCA1 ARHGAP25 RGS10	5.85e-05	191	96	5	51f5af610983aa73b9f4ece6f27d281ebff89a04
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MRC1 PLB1 ABCA1 ARHGAP25 RGS10	5.85e-05	191	96	5	8fd6bdc9d2b1c8d364221d7bc68d03921b668ab5
ToppCell	Entopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	MYCBP2 SPTBN2 ANKRD12 CEP170B SLC12A5	5.85e-05	191	96	5	5d24022cec293bc8d9e978ae99a109e660bb8f83
ToppCell	Entopeduncular-Neuronal-Inhibitory\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	MYCBP2 SPTBN2 ANKRD12 CEP170B SLC12A5	5.85e-05	191	96	5	73dae4cdea86aec62393ad7303dc7375a6b3fc86
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	USP34 WASF2 APOB CDH1 ITGB1	5.85e-05	191	96	5	09db184cb90fe282a14474d7217068c58092c6f8
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	USP34 WASF2 APOB CDH1 ITGB1	5.85e-05	191	96	5	973117730d6ba5f127e7a0bfabfd0ff2ca7ac131
ToppCell	Entopeduncular-Neuronal\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	MYCBP2 SPTBN2 ANKRD12 CRMP1 SLC12A5	5.99e-05	192	96	5	4c35e5c28a40b439044797ba1f06cb7c36b2a8de
ToppCell	droplet-Kidney-nan-18m-Epithelial-Epcam_____kidney_distal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC12A3 KALRN ABCA13 CADPS2 CDH1	5.99e-05	192	96	5	6fb56d062c35617b18b927704bf5fba894faed81
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NEFL KALRN ADGRB2 CADPS2 ITPR1	5.99e-05	192	96	5	5c7e8b80b44d9ce55c797cdf8267ac5382e26cac
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASGRF1 KALRN KCNF1 CRMP1 SLC12A5	6.14e-05	193	96	5	461919ab422bc9d1fcff7a3a4757c75239041d7e
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASGRF1 KALRN KCNF1 CRMP1 SLC12A5	6.14e-05	193	96	5	0dd810ad900d3e586551622b2c1de39d76fd6a7f
ToppCell	Thalamus-Neuronal\|Thalamus / BrainAtlas - Mouse McCarroll V32	NEFL SPTBN2 UNC79 CRMP1 SLC12A5	6.14e-05	193	96	5	712a4acd1167e43543950bc819ff11984e6f718d
ToppCell	CF-Lymphoid-B_cell\|Lymphoid / Disease state, Lineage and Cell class	PIKFYVE ANKRD13A TRIO MYCBP2 ARHGAP25	6.14e-05	193	96	5	7ebf20344a9a154fd2cffa281526867fcf0aded3
ToppCell	droplet-Kidney-nan-18m-Epithelial-kidney_distal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC12A3 KALRN ABCA13 CADPS2 CDH1	6.14e-05	193	96	5	fa8bcf2a5ab7b08fae98a1466a936995142b4309
ToppCell	Smart-seq2-lymph_node_(Smart-seq2)-lymphocytic-B_lymphocytic-B_cell\|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	PIKFYVE ANKRD13A MYCBP2 LYST ITPR1	6.30e-05	194	96	5	ff661419b697aef51a53fdeac8d37d870d65f491
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MRC1 PLB1 ABCA1 ARHGAP25 RGS10	6.30e-05	194	96	5	1dce6d4b6ac41f80677e3e4c335a4f383bd76f85
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASGRF1 KALRN KCNF1 CRMP1 SLC12A5	6.45e-05	195	96	5	ffbab350e67d9c4b66c0ab84550daec8b8139a27
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PDE3B SLC12A2 SPTBN2 CADPS2 CDH1	6.45e-05	195	96	5	3f517c6fc372bdcaf45b3af373414f13cbebd4ba
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	FAM133B USP34 PDE3B ANKRD12 SIN3A	6.45e-05	195	96	5	ed5f772c82d4dfd1c8735224446ec9feae3fb8c2
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MRC1 PLB1 ABCA1 ARHGAP25 RGS10	6.45e-05	195	96	5	34a9462f4e843f3065cc58c17ad71c1b5b836ae1
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	PLB1 RNMT CADPS2 CDH1 UTRN	6.77e-05	197	96	5	b94645d57efe8d9e032bffb8c89af1f425c6421e
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-2M-Neuronal-ventral_progenitors_and_neurons_1\|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.	NEFL RASGRF1 MYCBP2 KCNF1 SLC12A5	6.77e-05	197	96	5	4961f66606f08e399508fd6cabca588e7ab406a8
ToppCell	Somatosensory_Cortex_(S1)-Neuronal\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	OXR1 KALRN UNC79 SLC12A5 ITPR1	6.93e-05	198	96	5	c01091ef18e096d792ea2a7a715764a5b215355f
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	OXR1 KALRN UNC79 SLC12A5 ITPR1	6.93e-05	198	96	5	8ab40fae14fe02e39bc8c8da187a5cd60c787643
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	OXR1 KALRN UNC79 SLC12A5 ITPR1	6.93e-05	198	96	5	4ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	USP34 TRIO WDFY3 CADPS2 UTRN	7.10e-05	199	96	5	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	Frontal_cortex-Neuronal\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	USP34 ANKRD12 CEP170B CRMP1 SLC12A5	7.10e-05	199	96	5	f88039d862f3bfa01dc39d2de4f3f548dc5a0e61
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW26-Neuronal-GABAergic_neurons\|GW26 / Sample Type, Dataset, Time_group, and Cell type.	DPYSL3 KALRN MYCBP2 ANKRD12 CRMP1	7.27e-05	200	96	5	bad32a95b759fad509401b07bc96a56687c2a592
ToppCell	mLN-Macrophage-LYVE1_Macrophage\|Macrophage / Region, Cell class and subclass	MRC1 CMTM3 SUPT16H LRPAP1 ITGB1	7.27e-05	200	96	5	e3c15e0e1c2602b0cc9ab8cc50c978d265350c94
ToppCell	Neuronal\|World / cells hierarchy compared to all cells using T-Statistic	OXR1 KALRN MYCBP2 UNC79 SLC12A5	7.27e-05	200	96	5	48d801219bc771d6c7e151dc88ca4c179988de85
ToppCell	Control_saline-Endothelial-Endothelial-Alv_Gen_Intermediate\|Control_saline / Treatment groups by lineage, cell group, cell type	CMTM3 DPYSL3 PDE3B SLC12A2 CRMP1	7.27e-05	200	96	5	041a34080120c9f613373c20dcc366292f558040
ToppCell	Control_saline-Endothelial-Endothelial-Alv_Cap\|Control_saline / Treatment groups by lineage, cell group, cell type	CMTM3 DPYSL3 PDE3B SLC12A2 CRMP1	7.27e-05	200	96	5	abf4ba5fcb54cdeada0da1a8b956a30aa47679e4
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Myeloid-Macrophage-macrophage,_alveolar-Macro_c1-C1QC\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	MRC1 DPYSL3 NXNL1 KALRN	1.80e-04	130	96	4	92913960e4367261ba08a405b61a421bc5e18169
ToppCell	facs-Heart-LV-24m-Mesenchymal-atrial_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NEFL SLC12A3 IZUMO1 GCA	2.59e-04	143	96	4	8f82b3c3331f20c6ded36dbfb9a48dbd9f099f93
ToppCell	facs-Heart-LV-24m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NEFL SLC12A3 IZUMO1 GCA	2.59e-04	143	96	4	52832321cc848739ff6483f467d57c50c8b7395c
ToppCell	COVID-19-Mast_cells-Transitioning_MDM\|COVID-19 / group, cell type (main and fine annotations)	SLC8A3 FBXO24 MMRN2 UNC79	2.73e-04	145	96	4	5c5fed4620c4c312d1052b8acad910453f7e8fcc
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Neuroendocrine_Carcinoma-2\|TCGA-Pancreas / Sample_Type by Project: Shred V9	TCP11X2 UNC79 CFAP99 SLC12A5	2.80e-04	146	96	4	bc2adef529d0bbfcccef7435401a47a6ffcc1832
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Neuroendocrine_Carcinoma\|TCGA-Pancreas / Sample_Type by Project: Shred V9	TCP11X2 UNC79 CFAP99 SLC12A5	2.80e-04	146	96	4	72c1e7e0c2b6ff6c4084af61fa19c2b8eab16eda
ToppCell	3'_v3-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	FAM133B PDE3B RNMT MACF1	2.88e-04	147	96	4	94998bc40f5c08295cfe3bdcbe43f13b1e564b3d
ToppCell	Globus_pallidus-Macroglia-POLYDENDROCYTE-P3-Tnr-Polydendrocyte.Tnr.Cyth3_(Cyth3)-\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	FAM133B ZNF131 LRPAP1 SIN3A	3.35e-04	153	96	4	553dff9688a1996d8f4ba16e60c683593d781389
ToppCell	Globus_pallidus-Macroglia-POLYDENDROCYTE-P3-Tnr-Polydendrocyte.Tnr.Cyth3_(Cyth3)\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	FAM133B ZNF131 LRPAP1 SIN3A	3.35e-04	153	96	4	88ca2d2c2ab19fbee13e18951b993ee05dd30f67
ToppCell	10x5'-Liver-Myeloid_Mac-Intestinal_macrophages\|Liver / Manually curated celltypes from each tissue	MRC1 ABCA1 ESPNL WDFY3	3.61e-04	156	96	4	9a897fc79c4fae94c5f2e9012d65297f9225e5e3
ToppCell	metastatic_Brain-Fibroblasts-Myofibroblasts\|Fibroblasts / Location, Cell class and cell subclass	DPYSL3 FAM133A KLHDC8A SPTBN2	3.78e-04	158	96	4	ab05f6d7968ccd6d3826cd71b763dbedc83822c3
Drug	Mephenesin [59-47-2]; Down 200; 22uM; HL60; HT_HG-U133A	USP34 ABCA1 PDE3B ERAP1 DIDO1 ARHGAP25 ANKRD12 WDFY3 UTRN RGS10	1.11e-08	197	96	10	2342_DN
Drug	plakin	SPTA1 SPTBN2 MACF1 COPS2 CDH1 UTRN	1.30e-06	82	96	6	CID000018752
Drug	Chlorambucil [305-03-3]; Down 200; 13.2uM; PC3; HT_HG-U133A	CLCN6 TRIO SPTBN2 WDFY3 CDH1 UTRN ITPR1	1.55e-05	189	96	7	3788_DN
Drug	CTK5H8263	SLC12A2 SLC12A5	1.76e-05	2	96	2	CID013879490
Drug	Imipenem [74431-23-5]; Down 200; 13.4uM; HL60; HG-U133A	PDE3B CLCN6 GCA MACF1 ANKRD12 CEP170B ITPR1	1.84e-05	194	96	7	1724_DN
Disease	Chediak-Higashi syndrome (implicated_via_orthology)	WDFY3 LYST	5.75e-05	4	92	2	DOID:2935 (implicated_via_orthology)
Disease	urate measurement, bone density	DPYSL3 PLB1 PDE3B MOV10L1 GBE1 ARHGAP25 CADPS2 UTRN ITPR1	1.37e-04	619	92	9	EFO_0003923, EFO_0004531
Disease	epilepsy (implicated_via_orthology)	SLC12A2 SLC12A3 TRIO KALRN SLC12A5	1.61e-04	163	92	5	DOID:1826 (implicated_via_orthology)
Disease	coronary artery disease (is_implicated_in)	ABCA1 CLCN6 KALRN APOB	2.76e-04	100	92	4	DOID:3393 (is_implicated_in)
Disease	Colorectal Carcinoma	ABCA1 KALRN ABCA13 SPTBN2 PAN2 MMRN2 APOB CDH1 SLC12A5	3.48e-04	702	92	9	C0009402
Disease	saturated fatty acids measurement	ABCA1 IZUMO1 APOB	3.79e-04	45	92	3	EFO_0022304
Disease	Schizophrenia	NEFL ABCA1 SLC12A2 ABCA13 SPTBN2 CADPS2 ME2 CRMP1 DNMT3L SLC12A5	4.31e-04	883	92	10	C0036341
Disease	cytochrome p450 3a4 measurement	PIKFYVE APOB	5.19e-04	11	92	2	EFO_0020303
Disease	sleep duration, high density lipoprotein cholesterol measurement	ABCA1 SLC12A3 MACF1 APOB	5.69e-04	121	92	4	EFO_0004612, EFO_0005271
Disease	cardiovascular disease	FAM133B USP34 PLB1 CLCN6 ERAP1 APOB CADPS2	5.77e-04	457	92	7	EFO_0000319
Disease	loneliness measurement	DPYSL3 GBE1 MACF1 UTRN	6.24e-04	124	92	4	EFO_0007865
Disease	Hyperlipoproteinemia Type IIb	ABCA1 APOB	7.33e-04	13	92	2	C1704417
Disease	membranous glomerulonephritis (biomarker_via_orthology)	ABCA1 LRPAP1	8.54e-04	14	92	2	DOID:10976 (biomarker_via_orthology)
Disease	Myopia	RASGRF1 LRPAP1	9.83e-04	15	92	2	C0027092
Disease	Hyperlipoproteinemia Type IIa	ABCA1 APOB	1.12e-03	16	92	2	C0745103
Disease	phospholipids:total lipids ratio, intermediate density lipoprotein measurement	ABCA1 MACF1 APOB	1.22e-03	67	92	3	EFO_0008595, EFO_0020946
Disease	alkaline phosphatase measurement	USP34 IZUMO1 MACF1 ARHGAP25 APOB MFSD13A UTRN CRMP1 SLC12A5 ITPR1	1.25e-03	1015	92	10	EFO_0004533
Disease	Hypercholesterolemia, Familial	ABCA1 APOB	1.42e-03	18	92	2	C0020445
Disease	complex trait	ABCA1 MMRN2 MACF1 APOB F13B	1.62e-03	271	92	5	EFO_0010578
Disease	reticulocyte measurement	PIKFYVE USP34 ABCA1 PDE3B SLC12A2 OXR1 SPTA1 ARHGAP25 CDH1 PCID2	1.64e-03	1053	92	10	EFO_0010700
Disease	preeclampsia	CLCN6 MYCBP2 PCID2	1.88e-03	78	92	3	EFO_0000668
Disease	eosinophil count	FAM133B KPNA7 PLB1 SLC9C1 WDR36 SLC12A2 FAM3A C6orf163 C16orf96 ME2 CLCF1 DNMT3L	2.24e-03	1488	92	12	EFO_0004842
Disease	Epilepsy, Benign Psychomotor, Childhood	SLC12A2 SLC12A5	2.33e-03	23	92	2	C0393672
Disease	Epilepsy, Lateral Temporal	SLC12A2 SLC12A5	2.33e-03	23	92	2	C0393682
Disease	Uncinate Epilepsy	SLC12A2 SLC12A5	2.33e-03	23	92	2	C0014558
Disease	Epilepsy, Temporal Lobe	SLC12A2 SLC12A5	2.33e-03	23	92	2	C0014556
Disease	Behcet Syndrome	ERAP1 APOB	2.54e-03	24	92	2	C0004943
Disease	Intellectual Disability	ZMYND11 OXR1 TRIO SUPT16H MACF1 SIN3A	2.78e-03	447	92	6	C3714756
Disease	lipid measurement, lipoprotein measurement	ABCA1 APOB TOP1	2.83e-03	90	92	3	EFO_0004529, EFO_0004732
Disease	Alzheimer disease, high density lipoprotein cholesterol measurement	ABCA1 APOB	2.98e-03	26	92	2	EFO_0004612, MONDO_0004975
Disease	free cholesterol measurement, high density lipoprotein cholesterol measurement	ABCA1 SLC12A3 IZUMO1 APOB TOP1	3.10e-03	315	92	5	EFO_0004612, EFO_0008591
Disease	Neurodevelopmental Disorders	TRIO WDFY3 ITPR1	3.11e-03	93	92	3	C1535926

Protein segments in the cluster

Peptide	Gene	Start	Entry
FMVDAENKEKWDDAQ	ADGRB2	671	O60241
EWGFKALKQMIKINF	COPS2	66	P61201
FWMFVDNLVLNKEDL	DNMT3L	281	Q9UJW3
FQKGDIPWDDKDFRM	AFG3L2	131	Q9Y4W6
WDKAVATGKMDENQF	DPYSL3	366	Q14195
ENNKWEMIKNGAFLD	GVINP1	846	Q7Z2Y8
TGKMGFNAFKELWAA	GCA	106	P28676
NKSMELLDERKFWAG	ABCA1	521	O95477
LEKDVFFWELKQMLA	ABCA13	486	Q86UQ4
KQLGIMTNWKDFLEE	C6orf163	266	Q5TEZ5
GEEFRMEKLNQLWEK	LRPAP1	51	P30533
FMSWLQDVDDKFDKL	ANKRD12	1986	Q6UB98
EKMKILFQNTGRAWE	CEP170B	1456	Q9Y4F5
LKENIWMKDPFAFQN	FAM200A	446	Q8TCP9
ENVLFWLACEDFKKM	RGS10	66	O43665
FEKEKMNAKWDTGEN	ITGB1	766	P05556
FIFKGEDNWAELMEV	ANKRD13A	176	Q8IZ07
SEFFEWQKKMQAKDR	CFAP99	331	D6REC4
KEADFWRMQAEVAFK	PAN2	751	Q504Q3
INRSFAFWKEKEAEM	ESPNL	986	Q6ZVH7
LKNGEFKVQKEAVWM	KPNA7	376	A9QM74
KALAEFEEKMNENWK	FAM133A	56	Q8N9E0
GWDKSKQFRFQMLDK	MOV10L1	311	Q9BXT6
EDLFNEMNWQKKLRA	ITPR1	2256	Q14643
FAMAELQKGERVWFE	MMRN2	911	Q9H8L6
FMGFKADIILWDYKN	CFAP52	86	Q8N1V2
EENIGWMDKNFDKIR	ERAP1	916	Q9NZ08
FTEMEKNNLLLKWDF	F13B	586	P05160
MEKINNVTEFIFWGL	OR4S2	1	Q8NH73
NWNFPIFELVEKMGE	PDE3B	676	Q13370
EQEFVDDLKNMWFGL	ENDOU	256	P21128
QLRLFEQDAEKMFDW	KALRN	311	O60229
AKEIQDKLDQMVFFW	MACF1	5971	Q9UPN3
DKLDQMVFFWEDIKA	MACF1	5976	Q9UPN3
VFKWTGDNMFFIKGD	OXR1	806	Q8N573
RAFDMWAGDVNDLLK	FAM3A	121	P98173
EDSKKWGMLFLVNQL	PCID2	161	Q5JVF3
FAQKEMEEGEFKNWI	PIKFYVE	1451	Q9Y2I7
FIINEKMNGKVWDLF	EIF3CL	756	B5ME19
QDWAKRMKALVEQGF	APOB	2571	P04114
LMVAKWTGDFFNKGI	CLCN6	561	P51797
LLKEFKDEDWNMGDI	GBE1	446	Q04446
KALAEFEEKMNENWK	FAM133B	56	Q5BKY9
MDIFAEDFKIQNWKM	C16orf96	181	A6NNT2
IWKGFINMQSVAKFV	DIDO1	1056	Q9BTC0
DLFWKLDALQMFVFD	CADPS2	1011	Q86UW7
FDLEDVRNMGLFQKW	LYST	2411	Q99698
AQKDFFWEALDMLQR	FBXO24	551	O75426
NNWMKSVLIGEFLEK	RNMT	176	O43148
GLSEQEAQKKIWMFD	ME2	331	P23368
EQGGWLKMERSFFLK	KLHDC8A	251	Q8IYD2
DVKGDLFVKELFWML	IZUMO1	101	Q8IYV9
NDLKTQKMGQLRDWF	CEP295	1766	Q9C0D2
QILKPEAKMNEGFEW	DUSP12	146	Q9UNI6
EAKMNEGFEWQLKLY	DUSP12	151	Q9UNI6
KINKMAFWVGETVFL	MFSD13A	46	Q14CX5
WDKAVATGKMDENQF	CRMP1	366	Q14194
YLNEWGNRFKKLADM	CDH1	861	P12830
GIKDFFSMKPEWENL	SLC12A5	1051	Q9H2X9
KMLGIFWFNTKEISF	OR52E8	86	Q6IFG1
CFKIFGFMEEERKNW	MRC1	956	P22897
GFMEEERKNWQEARK	MRC1	961	P22897
WMDGVKDFLMKQQAA	UTRN	1031	P46939
EDMWEQKFLQFKLGA	MRPL46	121	Q9H2W6
KLFDDDLIQDFLWMD	SPDYA	76	Q5MJ70
ALKFDKDLANADWNM	SLC9C1	456	Q4G0N8
EKELAELGWKFLNLM	TCP11X2	361	Q5H9J9
MKEEEWREAQRGFNK	SIN3A	701	Q96ST3
EKGDWNKLGILDMFL	MYCBP2	4096	O75592
NMKENLQLDFQFDWK	PLB1	151	Q6P1J6
FMKSWNDCLNKEGFD	SUPT16H	146	Q9Y5B9
EFFGQGWMKLEKNER	RASGRF1	1061	Q13972
DLLNFKKGWMSILDE	TRIOBP	1776	Q9H2D6
FLFADAMQLNDKWQG	CMTM3	81	Q96MX0
SDFLQKMDDFWLLKE	CLCF1	176	Q9UBD9
GLQMVKKNFEWVAER	PAICS	241	P22234
RVVDKLWQGMFNKES	WDFY3	2051	Q8IZQ1
LWQGMFNKESKLLID	WDFY3	2056	Q8IZQ1
QQDLFLKDMPKKWLF	NXNL1	86	Q96CM4
FMWALKNGDLDEVKD	MTPN	6	P58546
AFMAELAANKDWLDK	SPTBN2	1321	O15020
GANSSKMEIFKNEFW	ARHGAP25	456	P42331
LGFKKDWLQADMRDV	SLC12A2	886	P55011
LAGMEWESKAQVLFF	SLC12A3	276	P55017
QVFKRDADDLGKWIM	SPTA1	56	P02549
NMGFAEAFLEPLWKK	RRN3P2	261	A6NIE6
FFDLWKEKMLQDTKD	WASF2	156	Q9Y6W5
FGFWPAKVMQKEDNQ	ZMYND11	291	Q15326
WKAAEFLQMLEAIKA	ZNF131	106	P52739
WAEKELNMMKLFFDN	USP34	946	Q70CQ2
VEKQTLALMFQKDFW	WDR87	2681	Q6ZQQ6
LALMFQKDFWDFKDK	WDR87	2686	Q6ZQQ6
KNFFKDWRKEMTNEE	TOP1	276	P11387
QLRLFEQDAEKMFDW	TRIO	341	O75962
NQGKVEAFEKMLWRV	ATP6V0A2	181	Q9Y487
NFNSKDWKMRFEAVE	UNC79	1051	Q9P2D8
IKFNETLMKFRQDWG	WDR36	276	Q8NI36
NEMDFWKVDLKFLDD	KCNF1	111	Q9H3M0
QENFFIALGEPKWME	SLC8A3	611	P57103
EKGQVRFWMQAEKLS	MYOM1	1256	P52179
EKLAAKNMQNAEEWF	NEFL	266	P07196