Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainDeath_domain

UNC5B IRAK1 MALT1 NFKB2

5.79e-05381044IPR000488
DomainCYSTEINE_SWITCH

MMP27 ADAMTS16 ADAM17 MMP15

7.84e-05411044PS00546
Domain-

ADAMTS2 MMP27 ADAMTS16 ADAM17 MMP15

8.90e-058110453.40.390.10
DomainMetalloPept_cat_dom

ADAMTS2 MMP27 ADAMTS16 ADAM17 MMP15

8.90e-05811045IPR024079
DomainPept_M10_metallopeptidase

MMP27 ADAMTS16 ADAM17 MMP15

9.47e-05431044IPR001818
DomainZINC_PROTEASE

ADAMTS2 MMP27 ADAMTS16 ADAM17 MMP15

2.19e-04981045PS00142
DomainANION_EXCHANGER_2

SLC4A7 SLC4A8

6.33e-0471042PS00220
DomainANION_EXCHANGER_1

SLC4A7 SLC4A8

6.33e-0471042PS00219
DomainDeath

UNC5B IRAK1 NFKB2

8.10e-04331043PF00531
Domain-

SLC4A7 SLC4A8

1.08e-03910423.40.1100.10
DomainBand3_cytoplasmic_dom

SLC4A7 SLC4A8

1.08e-0391042IPR013769
DomainBand_3_cyto

SLC4A7 SLC4A8

1.08e-0391042PF07565
DomainDEATH_DOMAIN

UNC5B MALT1 NFKB2

1.23e-03381043PS50017
DomainPep_M12B_propep

ADAMTS2 ADAMTS16 ADAM17

1.33e-03391043PF01562
DomainPeptidase_M12B_N

ADAMTS2 ADAMTS16 ADAM17

1.33e-03391043IPR002870
DomainPTrfase/Anion_transptr

SLC4A7 SLC4A8

1.34e-03101042IPR016152
DomainHCO3_transpt_euk

SLC4A7 SLC4A8

1.34e-03101042IPR003020
DomainHCO3_cotransp

SLC4A7 SLC4A8

1.34e-03101042PF00955
DomainHCO3_transpt_C

SLC4A7 SLC4A8

1.34e-03101042IPR011531
DomainAdenylat/UMP-CMP_kin

AK9 AK2

1.34e-03101042IPR000850
DomainDISINTEGRIN_1

ADAMTS2 ADAMTS16 ADAM17

1.43e-03401043PS00427
DomainReprolysin

ADAMTS2 ADAMTS16 ADAM17

1.43e-03401043PF01421
DomainADAM_MEPRO

ADAMTS2 ADAMTS16 ADAM17

1.43e-03401043PS50215
DomainDISINTEGRIN_2

ADAMTS2 ADAMTS16 ADAM17

1.43e-03401043PS50214
DomainPeptidase_M12B

ADAMTS2 ADAMTS16 ADAM17

1.43e-03401043IPR001590
DomainDisintegrin_dom

ADAMTS2 ADAMTS16 ADAM17

1.53e-03411043IPR001762
Domain-

UNC5B IRAK1 MALT1 NFKB2

1.81e-039310441.10.533.10
DomainDEATH-like_dom

UNC5B IRAK1 MALT1 NFKB2

2.28e-03991044IPR011029
DomainRasGAP

RASA1 RASA2

2.68e-03141042SM00323
DomainDynein_heavy_chain_D4_dom

DNAH7 DNAH5

2.68e-03141042IPR024317
DomainDynein_HC_stalk

DNAH7 DNAH5

2.68e-03141042IPR024743
DomainDynein_heavy_dom-2

DNAH7 DNAH5

2.68e-03141042IPR013602
DomainDHC_N2

DNAH7 DNAH5

2.68e-03141042PF08393
DomainMT

DNAH7 DNAH5

2.68e-03141042PF12777
DomainAAA_8

DNAH7 DNAH5

2.68e-03141042PF12780
DomainRasGAP_CS

RASA1 RASA2

2.68e-03141042IPR023152
DomainDHC_fam

DNAH7 DNAH5

3.08e-03151042IPR026983
DomainRasGAP

RASA1 RASA2

3.08e-03151042PF00616
DomainRAS_GTPASE_ACTIV_1

RASA1 RASA2

3.08e-03151042PS00509
DomainDynein_heavy

DNAH7 DNAH5

3.08e-03151042PF03028
DomainPept_M10A_Zn_BS

MMP27 MMP15

3.08e-03151042IPR021158
DomainRAS_GTPASE_ACTIV_2

RASA1 RASA2

3.08e-03151042PS50018
DomainDynein_heavy_dom

DNAH7 DNAH5

3.08e-03151042IPR004273
Domain-

RASA1 RASA2

3.50e-031610421.10.506.10
DomainHemopexin_CS

MMP27 MMP15

3.95e-03171042IPR018486
DomainG_crystallin-rel

ADAMTS2 CRYBG3

4.43e-03181042IPR011024
DomainPept_M10A_stromelysin-type

MMP27 MMP15

4.43e-03181042IPR016293
DomainHATPase_c

PMS2 TOP2A

4.43e-03181042SM00387
DomainRasGAP_dom

RASA1 RASA2

4.43e-03181042IPR001936
DomainPLAC

ADAMTS2 ADAMTS16

4.94e-03191042PS50900
DomainHATPase_c

PMS2 TOP2A

4.94e-03191042PF02518
DomainPLAC

ADAMTS2 ADAMTS16

4.94e-03191042IPR010909
DomainTSP_1

ADAMTS2 UNC5B ADAMTS16

5.23e-03631043PF00090
DomainPG_binding_1

MMP27 MMP15

5.47e-03201042PF01471
DomainPeptidoglycan-bd-like

MMP27 MMP15

5.47e-03201042IPR002477
Pubmed

Immunocytochemical identification of electroneutral Na⁺-coupled HCO₃⁻ transporters in freshly dissociated mouse medullary raphé neurons.

SLC4A7 SLC4A8 TPH1

2.74e-075106323500099
Pubmed

USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.

FER1L6 KMT2D LRBA DMD DNAH5 THRAP3 TOP2A VPS13B

6.37e-07234106836243803
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

GPHN IRAK1 KMT2D PDLIM1 BRD4 LRBA PLS3 THRAP3 TOP2A CNN3 HDLBP

9.88e-075491061138280479
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

PMS2 DNAJC13 ST7 PSMD2 APLP2 BANF1 KMT2D NUP210 AK2 CRYBG3 MAPK1 DMD TNS1 HDLBP

3.80e-0610491061427880917
Pubmed

Luzp4 defines a new mRNA export pathway in cancer cells.

BANF1 THOC5 PDLIM1 PLS3 THRAP3

4.79e-0680106525662211
Pubmed

Elongation factor-2 kinase acts downstream of p38 MAPK to regulate proliferation, apoptosis and autophagy in human lung fibroblasts.

EEF2K MAPK1

9.20e-062106229355493
Pubmed

Reactive oxygen species and p38 mitogen-activated protein kinase mediate tumor necrosis factor α-converting enzyme (TACE/ADAM-17) activation in primary human monocytes.

ADAM17 MAPK1

9.20e-062106221865167
Pubmed

Extracellular signal-regulated kinase activates topoisomerase IIalpha through a mechanism independent of phosphorylation.

MAPK1 TOP2A

9.20e-062106210207078
Pubmed

Targeted degradation via direct 26S proteasome recruitment.

PSMD2 BRD4

9.20e-062106236577875
Pubmed

ERK2-topoisomerase II regulatory axis is important for gene activation in immediate early genes.

MAPK1 TOP2A

9.20e-062106238097570
Pubmed

Intron-less processed Pcdhalpha genes in the central nervous system.

PCDHA8 PCDHA6

9.20e-062106214697259
Pubmed

Plastin 3 down-regulation augments the sensitivity of MDA-MB-231 cells to paclitaxel via the p38 MAPK signalling pathway.

MAPK1 PLS3

9.20e-062106230829071
Pubmed

Pigmentation-related genes and their implication in malignant melanoma susceptibility.

MLANA MYO7A VPS13B

9.77e-0614106319320733
Pubmed

BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.

ZC3H15 UNC5B IRAK1 PSMD2 PDLIM1 CRYBG3 LRBA QARS1 PLS3 CNN3 HDLBP

1.11e-057081061139231216
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

CACNB2 DNAJC13 LRRN1 RASA1 RASA2 ST7 RPS6KB1 FNBP1L PCGF3 GTF2IRD1 MALT1 NUP210 LRBA SH3RF3 THRAP3 VPS13B

1.14e-0514891061628611215
Pubmed

Telencephalic embryonic subtractive sequences: a unique collection of neurodevelopmental genes.

SLC4A7 RHOBTB3 FNBP1L THRAP3 TOP2A CNN3

1.20e-05165106616107646
Pubmed

A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.

DNAJC13 ZC3H15 FNBP1L THOC5 PRKRA RIOX2 AGO1 QARS1 THRAP3 CNN3 HDLBP

1.37e-057241061136232890
Pubmed

Serotonin stimulates platelet receptor shedding by tumor necrosis factor-alpha-converting enzyme (ADAM17).

ADAM17 TPH1

2.76e-053106219426283
Pubmed

Expression and inhibition of BRD4, EZH2 and TOP2A in neurofibromas and malignant peripheral nerve sheath tumors.

BRD4 TOP2A

2.76e-053106228813519
Pubmed

Regulation of the human NBC3 Na+/HCO3- cotransporter by carbonic anhydrase II and PKA.

SLC4A7 SLC4A8

2.76e-053106214736710
Pubmed

IL-1 receptor-associated kinase 1 is critical for latent membrane protein 1-induced p65/RelA serine 536 phosphorylation and NF-kappaB activation.

IRAK1 NFKB2

2.76e-053106216477006
Pubmed

h3/Acidic calponin: an actin-binding protein that controls extracellular signal-regulated kinase 1/2 activity in nonmuscle cells.

MAPK1 CNN3

2.76e-053106220181831
Pubmed

Molecular crosstalk between p70S6k and MAPK cell signaling pathways.

RPS6KB1 MAPK1

2.76e-053106212054624
Pubmed

Loss of dystrophin causes aberrant mechanotransduction in skeletal muscle fibers.

MAPK1 DMD

2.76e-053106214718391
Pubmed

Lysine methyltransferase 2D regulates muscle fiber size and muscle cell differentiation.

KMT2D DMD

2.76e-053106234613626
Pubmed

Oocyte-dependent activation of mitogen-activated protein kinase (ERK1/2) in cumulus cells is required for the maturation of the mouse oocyte-cumulus cell complex.

MAD2L1BP MAPK1

2.76e-053106214568551
Pubmed

The COOH termini of NBC3 and the 56-kDa H+-ATPase subunit are PDZ motifs involved in their interaction.

SLC4A7 SLC4A8

2.76e-053106212444018
Pubmed

Shedding of the amyloid precursor protein-like protein APLP2 by disintegrin-metalloproteinases.

APLP2 ADAM17

2.76e-053106216279945
Pubmed

Agrin has a pathological role in the progression of oral cancer.

UBE2NL ZC3H15 AGR2 ADAM17 DMD HDLBP

3.26e-05197106629872149
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

TNIK GPHN CACNB2 DNAJC13 SLC4A8 RPS6KB1 DGKZ AGO1 UBE2N MAPK1 TNS1 THRAP3

3.84e-059631061228671696
Pubmed

BCAR1 promotes proliferation and cell growth in lung adenocarcinoma via upregulation of POLR2A.

APOBEC3H TRMT11 BRD4 NUP210 METTL16 LRBA DMD ATL2

4.47e-05419106833001583
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

TNIK DNAJC13 SLC4A7 ZC3H15 ST7 UNC5B OBSL1 THOC5 UBE2N NUP210 EEF2K CRYBG3 PLS3 VPS13B HDLBP

4.55e-0514871061533957083
Pubmed

The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation.

UBE2NL ZC3H15 LANCL1 PSMD2 DNAH7 BANF1 AGO1 UBE2N NUP210 MAPK1 METTL16 PLS3 THRAP3

5.01e-0511531061329845934
Pubmed

Tumor-suppressor NFκB2 p100 interacts with ERK2 and stabilizes PTEN mRNA via inhibition of miR-494.

NFKB2 MAPK1

5.50e-054106226686085
Pubmed

Widespread deregulation of phosphorylation-based signaling pathways in multiple myeloma cells: opportunities for therapeutic intervention.

RPS6KB1 MAPK1

5.50e-054106221541441
Pubmed

The cystic fibrosis transmembrane conductance regulator interacts with and regulates the activity of the HCO3- salvage transporter human Na+-HCO3- cotransport isoform 3.

SLC4A7 SLC4A8

5.50e-054106212403779
Pubmed

Dystroglycan is selectively associated with inhibitory GABAergic synapses but is dispensable for their differentiation.

GPHN DMD

5.50e-054106212040032
Pubmed

Molecular expression of SLC4-derived Na+-dependent anion transporters in selected human tissues.

SLC4A7 SLC4A8

5.50e-054106217715183
Pubmed

Blood vascular abnormalities in Rasa1(R780Q) knockin mice: implications for the pathogenesis of capillary malformation-arteriovenous malformation.

RASA1 MAPK1

5.50e-054106225283357
Pubmed

Essential role of the linear ubiquitin chain assembly complex in lymphoma revealed by rare germline polymorphisms.

IRAK1 MALT1

5.50e-054106224491438
Pubmed

Ubiquitin-conjugating enzyme Ubc13 controls breast cancer metastasis through a TAK1-p38 MAP kinase cascade.

UBE2N MAPK1

5.50e-054106225189770
Pubmed

Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS.

ZC3H15 OBSL1 PCGF3 PRKRA EEF2K MAPK1 THRAP3 VPS13B

5.54e-05432106823455922
Pubmed

Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

TNIK SLC4A7 PDLIM1 EEF2K THRAP3

5.64e-05133106515144186
Pubmed

Genomic analysis of mouse retinal development.

GPHN CACNB2 PMS2 CFAP251 RPS6KB1 PSMD2 PRKRA AKR1E2 BRD4 MAPK1 THRAP3 TPH1

5.84e-0510061061215226823
Pubmed

The human cytoplasmic dynein interactome reveals novel activators of motility.

TNIK ST7 RPS6KB1 IRAK1 DNAH7 AGO1 PDLIM1 PLS3 TOP2A CNN3 TRDMT1

6.07e-058531061128718761
Pubmed

The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.

TNIK SLC4A7 SLC4A8 UNC5B FRMD7 APLP2 ATP10D LRBA VPS13B

6.34e-05569106930639242
Pubmed

High Throughput Chemical Screening Reveals Multiple Regulatory Proteins on FOXA1 in Breast Cancer Cell Lines.

LANCL1 BANF1 PRKRA PDLIM1 UBE2N THRAP3

6.50e-05223106630572598
Pubmed

BPA modulates the WDR5/TET2 complex to regulate ERβ expression in eutopic endometrium and drives the development of endometriosis.

ZC3H15 PSMD2 FNBP1L PRKRA KMT2D MAPK1 METTL16 TNS1 THRAP3 HDLBP

6.54e-057111061033022573
Pubmed

Unconventional myosin VI in the heart: Involvement in cardiac dysfunction progressing with age.

RPS6KB1 MAPK1 DMD

7.63e-0527106337169038
Pubmed

Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.

RPS6KB1 MMP27 PCGF3 UBE2N BRD4 GBGT1 MAPK1 MMP15 DNAH5 THRAP3

8.13e-057301061034857952
Pubmed

Synemin acts as a regulator of signalling molecules during skeletal muscle hypertrophy.

RPS6KB1 MAPK1 DMD

8.53e-0528106325179606
Pubmed

Uev1A-Ubc13 catalyzes K63-linked ubiquitination of RHBDF2 to promote TACE maturation.

UBE2N ADAM17

9.15e-055106229069608
Pubmed

Dopamine D2 receptor-mediated epidermal growth factor receptor transactivation through a disintegrin and metalloprotease regulates dopaminergic neuron development via extracellular signal-related kinase activation.

ADAM17 MAPK1

9.15e-055106223955337
Pubmed

Phosphorylation of eukaryotic elongation factor 2 (eEF2) by cyclin A-cyclin-dependent kinase 2 regulates its inhibition by eEF2 kinase.

EEF2K MAPK1

9.15e-055106223184662
Pubmed

Phosphotyrosine-independent binding of a 62-kDa protein to the src homology 2 (SH2) domain of p56lck and its regulation by phosphorylation of Ser-59 in the lck unique N-terminal region.

RASA1 MAPK1

9.15e-05510628618896
Pubmed

MEK1/2 overactivation can promote growth arrest by mediating ERK1/2-dependent phosphorylation of p70S6K.

RPS6KB1 MAPK1

9.15e-055106224501087
Pubmed

Functional role of extracellular signal-regulated kinase activation and c-Jun induction in phorbol ester-induced promoter activation of human 12(S)-lipoxygenase gene.

MAPK1 ALOX12

9.15e-055106211914583
Pubmed

Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation.

MALT1 UBE2N

9.15e-055106217135271
Pubmed

Ras participates in the activation of p38 MAPK by interleukin-1 by associating with IRAK, IRAK2, TRAF6, and TAK-1.

IRAK1 MAPK1

9.15e-055106211744690
Pubmed

Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.

OBSL1 L1TD1 KMT2D UBE2N BRD4 NUP210 CRISPLD1 TOP2A

9.80e-05469106827634302
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

GPHN CACNB2 DNAJC13 MYO7A PSMD2 DGKZ PRKRA AGO1 MAPK1 DMD TNS1 PLS3 THRAP3 HDLBP

1.15e-0414311061437142655
Pubmed

Bromodomain Protein BRD4 Is Essential for Hair Cell Function and Survival.

MYO7A BRD4

1.37e-046106233015071
Pubmed

CXCL4L1 and CXCL4 signaling in human lymphatic and microvascular endothelial cells and activated lymphocytes: involvement of mitogen-activated protein (MAP) kinases, Src and p70S6 kinase.

RPS6KB1 MAPK1

1.37e-046106224469069
Pubmed

Expression levels of the microRNA maturing microprocessor complex component DGCR8 and the RNA-induced silencing complex (RISC) components argonaute-1, argonaute-2, PACT, TARBP1, and TARBP2 in epithelial skin cancer.

PRKRA AGO1

1.37e-046106222025453
Pubmed

NEDD4 controls the expression of GUCD1, a protein upregulated in proliferating liver cells.

PCDHA8 PCDHA6

1.37e-046106224743017
Pubmed

ERK1/2 phosphorylate Raptor to promote Ras-dependent activation of mTOR complex 1 (mTORC1).

RPS6KB1 MAPK1

1.37e-046106221071439
Pubmed

Functional Analysis of KIT Gene Structural Mutations Causing the Porcine Dominant White Phenotype Using Genome Edited Mouse Models.

MLANA MAPK1

1.37e-046106232194624
Pubmed

Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398.

RPS6KB1 EEF2K

1.37e-046106214709557
Pubmed

A novel mTOR-regulated phosphorylation site in elongation factor 2 kinase modulates the activity of the kinase and its binding to calmodulin.

RPS6KB1 EEF2K

1.37e-046106215024086
Pubmed

Juxtaposition of CNR protocadherins and reelin expression in the developing spinal cord.

PCDHA8 PCDHA6

1.37e-046106211312598
Pubmed

Glutamine-dependent antiapoptotic interaction of human glutaminyl-tRNA synthetase with apoptosis signal-regulating kinase 1.

MAPK1 QARS1

1.37e-046106211096076
Pubmed

A bead-based approach for large-scale identification of in vitro kinase substrates.

ZC3H15 THOC5 THRAP3 TOP2A HDLBP

1.47e-04163106522113938
Pubmed

LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition.

MYO7A ZC3H15 DGKZ UBE2N METTL16

1.69e-04168106530631154
Pubmed

Depletion of skeletal muscle satellite cells attenuates pathology in muscular dystrophy.

MAPK1 DMD

1.91e-047106235618700
Pubmed

FAM177A1 Inhibits IL-1β-Induced Signaling by Impairing TRAF6-Ubc13 Association.

IRAK1 UBE2N

1.91e-047106234799425
Pubmed

Matrix Metalloproteinase-9 gene induction by a truncated oncogenic NF-kappaB2 protein involves the recruitment of MLL1 and MLL2 H3K4 histone methyltransferase complexes.

KMT2D NFKB2

1.91e-047106219219072
Pubmed

TRIM15 and CYLD regulate ERK activation via lysine-63-linked polyubiquitination.

UBE2N MAPK1

1.91e-047106234497368
Pubmed

Blockade of the Ras/MEK/ERK and Ras/PI3K/Akt pathways by statins reduces the expression of bFGF, HGF, and TGF-β as angiogenic factors in mouse osteosarcoma.

RASA1 MAPK1

1.91e-047106221292498
Pubmed

Bcl3 Phosphorylation by Akt, Erk2, and IKK Is Required for Its Transcriptional Activity.

NFKB2 MAPK1

1.91e-047106228689659
Pubmed

Lipopolysaccharide inhibits transforming growth factor-beta1-stimulated Smad6 expression by inducing phosphorylation of the linker region of Smad3 through a TLR4-IRAK1-ERK1/2 pathway.

IRAK1 MAPK1

1.91e-047106221295571
Pubmed

Extracellular signal-regulated kinase phosphorylates tumor necrosis factor alpha-converting enzyme at threonine 735: a potential role in regulated shedding.

ADAM17 MAPK1

1.91e-047106212058067
Pubmed

S6K1 phosphorylates and regulates fragile X mental retardation protein (FMRP) with the neuronal protein synthesis-dependent mammalian target of rapamycin (mTOR) signaling cascade.

RPS6KB1 MAPK1

1.91e-047106218474609
Pubmed

Interaction of gamma 1-syntrophin with diacylglycerol kinase-zeta. Regulation of nuclear localization by PDZ interactions.

DGKZ DMD

1.91e-047106211352924
Pubmed

FGF signalling regulates bone growth through autophagy.

RPS6KB1 FGF18 MAPK1

2.15e-0438106326595272
Pubmed

TIF1γ inhibits lung adenocarcinoma EMT and metastasis by interacting with the TAF15/TBP complex.

PSMD2 QARS1 PLS3 THRAP3 HDLBP

2.27e-04179106536261009
Pubmed

Nr2f1 heterozygous knockout mice recapitulate neurological phenotypes of Bosch-Boonstra-Schaaf optic atrophy syndrome and show impaired hippocampal synaptic plasticity.

MYO7A MMP15

2.55e-048106231600777
Pubmed

The IRAK-ERK-p67phox-Nox-2 axis mediates TLR4, 2-induced ROS production for IL-1β transcription and processing in monocytes.

IRAK1 MAPK1

2.55e-048106226320741
Pubmed

Four enzymes cooperate to displace histone H1 during the first minute of hormonal gene activation.

BANF1 KMT2D

2.55e-048106221447625
Pubmed

Molecular basis of human Usher syndrome: deciphering the meshes of the Usher protein network provides insights into the pathomechanisms of the Usher disease.

SLC4A7 MYO7A

2.55e-048106216545802
Pubmed

The endoplasmic reticulum adaptor protein ERAdP initiates NK cell activation via the Ubc13-mediated NF-κB pathway.

MALT1 UBE2N

2.55e-048106225548215
Pubmed

Regulation of endoplasmic reticulum-associated degradation by RNF5-dependent ubiquitination of JNK-associated membrane protein (JAMP).

PSMD2 UBE2N

2.55e-048106219269966
Pubmed

Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.

DNAJC13 ZC3H15 PSMD2 FNBP1L PRKRA UBE2N MAPK1 ATL2 QARS1 THRAP3 TOP2A CNN3 HDLBP

2.70e-0413671061332687490
Pubmed

The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.

DNAJC13 SLC4A7 LANCL1 PSMD2 CMC2 BRD4 NUP210 ADAM17 ATL2 QARS1 THRAP3 TOP2A

3.07e-0412031061229180619
Pubmed

Identification of an FMNL2 Interactome by Quantitative Mass Spectrometry.

SLC4A7 ZC3H15 UNC5B PLS3

3.19e-04106106438891874
Pubmed

Signal transduction pathways involved in phosphorylation and activation of p70S6K following exposure to UVA irradiation.

RPS6KB1 MAPK1

3.27e-049106211279232
Pubmed

The IRAK-1-BCL10-MALT1-TRAF6-TAK1 cascade mediates signaling to NF-kappaB from Toll-like receptor 4.

IRAK1 MALT1

3.27e-049106216831874
Pubmed

The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1.

IRAK1 UBE2N

3.27e-049106217997719
Pubmed

Phosphorylation of Msx1 promotes cell proliferation through the Fgf9/18-MAPK signaling pathway during embryonic limb development.

FGF18 MAPK1

3.27e-049106233080014
Pubmed

Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO.

MALT1 UBE2N

3.27e-049106214695475
Pubmed

Rac/ROS-related protein kinase C and phosphatidylinositol-3-kinase signaling are involved in a negative regulating cascade in B cell activation by antibody-mediated cross-linking of MHC class II molecules.

NFKB2 MAPK1

3.27e-049106219939451
GeneFamilyAdenylate kinases

AK9 AK2

6.00e-049752356
GeneFamilyPleckstrin homology domain containing|SH2 domain containing|C2 and RasGAP domain containing

RASA1 RASA2

7.48e-0410752830
CoexpressionAtlasDevelopingGonad_e12.5_testes_emap-29069_top-relative-expression-ranked_1000

MYO7A RHOBTB3 L1TD1 DGKZ GTF2IRD1 BANF1 UBE2N UCP2 ADAMTS16 PKNOX1 AK2 ATL2 TNS1 THRAP3 TOP2A HDLBP

2.02e-0681910316gudmap_developingGonad_e12.5_testes_1000
CoexpressionAtlasDevelopingGonad_e18.5_testes_emap-11164_top-relative-expression-ranked_1000

TDRD9 ADAMTS2 MYO7A RHOBTB3 OBSL1 APLP2 GTF2IRD1 BANF1 UBE2N UCP2 PKNOX1 AK2 ADAM17 TNS1

3.85e-0581410314gudmap_developingGonad_e18.5_testes_1000
ToppCellCOPD-Multiplet-Multiplet|COPD / Disease state, Lineage and Cell class

CFAP251 AGR2 FNBP1L DNAH7 DNAH5 TOP2A CNN3

4.53e-071961067af4cdc61830685a888a1209826c23bcf54a43084
ToppCellCOPD-Multiplet|COPD / Disease state, Lineage and Cell class

CFAP251 AGR2 FNBP1L DNAH7 DNAH5 TOP2A CNN3

4.53e-0719610676d02d494196e3f857d53eea46d9419690d43beca
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CFAP251 AGR2 AK9 DNAH7 DNAH5 CFAP157

4.06e-061761066dee780cfa85234a7cd7bf440b66b84cec959893e
ToppCellLPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CACNB2 LRRN1 FGF18 C1QTNF2 DMD CRISPLD1

4.47e-06179106602c90d8306016365ed811f0c63cfb3ac7b85464c
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CACNB2 SLC4A7 SLC4A8 RHOBTB3 CPEB3 LRBA

5.08e-06183106631ab55d5f3639f5964541d5eae23044dbda3356e
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CACNB2 LRRN1 ABHD12B FGF18 C1QTNF2 DMD

5.08e-0618310667eae9b3b4d1c9b135fa7cff348393d4adec474b4
ToppCellLPS_only-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CACNB2 LRRN1 RHOBTB3 C1QTNF2 DMD CRISPLD1

5.08e-06183106612daaea821e49bc94a01e2496331e92a80d27339
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CACNB2 LRRN1 FGF18 C1QTNF2 DMD CRISPLD1

5.41e-0618510663b2dfc8f4c87be516265dbecfc251276034d0efd
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CACNB2 SLC4A7 SLC4A8 RHOBTB3 CPEB3 LRBA

5.41e-061851066898a093757f86be3e18d2ef1f16a71f50ef81dc3
ToppCellILEUM-inflamed-(8)_Fibroblast-(8)_Smooth_muscle_cells|(8)_Fibroblast / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

MYO7A AGR2 APLP2 DMD HSD17B2 TNS1

5.57e-061861066cacc2f0b2ed46516173b61ba1c5c226a2db7cddc
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CACNB2 SLC4A7 SLC4A8 RHOBTB3 CPEB3 LRBA

5.75e-061871066b93cf4dfe8ffb89348ee7bccc9f284189f7240a2
ToppCellASK452-Epithelial-Ciliated|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq

CFAP251 AGR2 AK9 DNAH7 DNAH5 CFAP157

6.89e-061931066c0d10075862ac878aa05fc49c8b73e470783bf16
ToppCellASK452-Epithelial-Ciliated|ASK452 / Donor, Lineage and Cell class of Lung cells from Dropseq

CFAP251 AGR2 AK9 DNAH7 DNAH5 CFAP157

7.09e-0619410665aeb44657ab6f61b1abf98af28d3397d8e44c1aa
ToppCellfacs-Skin-Telogen-3m-Epithelial-bulge_keratinocyte|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

APLP2 FGF18 ARID5A DMD TNS1 PLS3

7.52e-06196106690edf61116ffcb4f8b6be3d0a05732d59b0a87d5
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CFAP251 AK9 DNAH7 DMD DNAH5 CFAP157

7.74e-06197106674a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCellTracheal-10x5prime-Epithelial-Epi_airway_ciliated-Deuterosomal|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

AK9 DNAH7 DNAH5 CRISPLD1 TOP2A CFAP157

7.74e-0619710666e4a411ef823ce9e16f420e185e21fa19d13af34
ToppCellLPS_IL1RA-Epithelial_airway-airway_epithelial|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

SLC4A8 AGR2 DNAH7 HSD17B2 DNAH5 CFAP157

8.44e-062001066cf191104484bfb2b9f87de416b9453135f8833c1
ToppCellLPS_IL1RA-Epithelial_airway|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

SLC4A8 AGR2 DNAH7 HSD17B2 DNAH5 CFAP157

8.44e-062001066a5ae33dd4dc1ff6e1a1eec22c4d523d5ab657607
ToppCell356C-Lymphocytic-NK_cells-NK_cell_A2|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

OBSL1 FNBP1L AKR1E2 DMD TOP2A

4.17e-0516110658ec923c230a7a3cce5edf2a736b3a00d607c698a
ToppCellmetastatic_Lymph_Node-T/NK_cells-Exhausted_Tfh|T/NK_cells / Location, Cell class and cell subclass

MYO7A ATP10D UCP2 NFKB2 DMD

5.26e-0516910653d48acea7482bbe5bb9da4c3af5f9b0c9800122f
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CFAP251 AK9 DNAH7 DNAH5 CFAP157

5.26e-05169106514aadc2d1bf66eb47dac33b4d61ddb3c942caa4f
ToppCellCiliated_cells-B-IPF_04|World / lung cells shred on cell class, cell subclass, sample id

CFAP251 DNAH7 DNAH5 UPP2 CFAP157

5.71e-051721065187ae91148d293537afc77e10da2b64302322224
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLC4A7 SLC4A8 RHOBTB3 CPEB3 LRBA

6.20e-051751065e5467dacf81f1f913b1719931cf1a7331434a7e7
ToppCell356C-Lymphocytic-NK_cells-NK_cell_A2|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

OBSL1 FNBP1L AKR1E2 DMD TOP2A

6.37e-051761065052b54c4337ca728974a106b6dbd3b72dd28eb23
ToppCell5'-GW_trimst-2-LargeIntestine-Epithelial-mature_enterocytic-Paneth|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TDRD9 AGR2 L1TD1 FER1L6 RIOX2

6.55e-0517710653743a7d69db9ac4cad70eb531f7075849f34f16b
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CFAP251 SLC4A8 DNAH7 ABCA5 CFAP157

6.72e-0517810653b12db04006db6e94fc45649a4b3a63b92f21a61
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CFAP251 ABHD12B DNAH7 DNAH5 CFAP157

7.09e-0518010651f1af4474f3f0ac3c0d6b1a6c875c354d36d8eec
ToppCellLPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CACNB2 LRRN1 FGF18 C1QTNF2 DMD

8.06e-0518510656712512100ccef456d2e2bd201d0987986c92ac9
ToppCellPND07-28-samps-Mesenchymal-Myofibroblast-myofibroblast_-_mature_-_C|PND07-28-samps / Age Group, Lineage, Cell class and subclass

ADAMTS2 UNC5B RHOBTB3 FGF18 C1QTNF2

8.06e-051851065427176ad9ab8d9511200fb0a132cfd1e835fe35c
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLC4A7 SLC4A8 RHOBTB3 CPEB3 LRBA

8.27e-0518610651850583d23903d08226aeb0edb3e07b0994330e4
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLC4A7 SLC4A8 RHOBTB3 CPEB3 LRBA

8.27e-0518610654dafc215c42e7949f932a3627359c107943b5d6b
ToppCellCOVID-19_Mild-Neu_4|COVID-19_Mild / 5 Neutrophil clusters in COVID-19 patients

PMS2 CFAP251 EEF2K TOP2A TPH1

8.48e-051871065714851e757c71c559ee6413a3f61d6c117c79ad2
ToppCellCOVID-19-kidney-Fibroblast-1|COVID-19 / Disease (COVID-19 only), tissue and cell type

CFAP251 ADAMTS2 DMD TNS1 SH3RF3

8.48e-05187106576bfe8c42430a230a8bdf299575c444fb7780f24
ToppCellLPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CACNB2 LRRN1 FGF18 C1QTNF2 DMD

8.70e-0518810653177b2c1723268d330d3e9f24f9e24492ace6286
ToppCellChildren_(3_yrs)-Immune-alveolar_macrophage_(MARCO_positive)-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

SLC4A8 UNC5B AKR1E2 PDLIM1 ADAM17

8.70e-051881065d7a9fb5b021e127b8d927658a55a71098d513b5c
ToppCell3'-Adult-Distal_Rectal-Mesenchymal-Pericytes|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

C1QTNF2 DMD TNS1 SH3RF3 PLS3

8.92e-051891065d69b7a01dd4d6ad043bb6210e9ab34b49578389c
ToppCell3'-Adult-Distal_Rectal-Mesenchymal-Pericytes-Contractile_pericyte_(PLN+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

C1QTNF2 DMD TNS1 SH3RF3 PLS3

8.92e-0518910652b5f1b4f173a224342ea4f10b193ee33b7662699
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CFAP251 ABHD12B DNAH7 DNAH5 CFAP157

8.92e-051891065b4b93bd10b7e3cc16e54ff73beac230f519c010a
ToppCell3'-Adult-Distal_Rectal-Mesenchymal|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

C1QTNF2 DMD TNS1 SH3RF3 PLS3

8.92e-05189106543e131458d8a4b120f7a5fb3d0c5650abded15f6
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CACNB2 LRRN1 FGF18 C1QTNF2 DMD

8.92e-05189106545e588b2a4ad9e3ff74e22d9d627ed3571f3b8b8
ToppCellPND07-28-samps-Mesenchymal-Myofibroblast|PND07-28-samps / Age Group, Lineage, Cell class and subclass

ADAMTS2 RHOBTB3 FGF18 C1QTNF2 PLS3

9.37e-0519110659bbafdf316c1fa3a9f1ee30d41dd7158b5c97279
ToppCellE18.5-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CFAP251 AGR2 AK9 DNAH5 CFAP157

9.37e-051911065acd844b477a069b2dcf07b2998e1b5c87dc0eb94
ToppCellCOVID-19-kidney-vSMC/Pericyte|kidney / Disease (COVID-19 only), tissue and cell type

CACNB2 ARID5A DMD SH3RF3 PLS3

9.37e-051911065fad8eaa536001b911d05ae2b12150c2398cc6f88
ToppCellASK428-Epithelial-Ciliated|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq

CFAP251 AGR2 AK9 DNAH5 CFAP157

9.37e-0519110650c4b926a28bc94f3cf4d68a911c0a189f6ff505e
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CACNB2 LRRN1 FGF18 C1QTNF2 DMD

9.37e-051911065b133ee1c0e58d00ddd2e4e05b01fd04947524c18
ToppCellBronchial_Biopsy-Epithelial-Ciliated_1|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X

CFAP251 AK9 DNAH7 DNAH5 CFAP157

9.60e-051921065be592e661367affced9ebe80849b466e6adb3a34
ToppCellmulticiliated|World / shred by cell class for turbinate

CFAP251 AK9 DNAH7 DNAH5 CFAP157

9.60e-0519210650f89ea0deb651ca11531c51ee94e0233608d22ea
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CFAP251 ADAMTS2 ATP10D PDLIM1 DMD

9.84e-051931065c8c21eee8c6c086dc2faf416669cd4a002870fbe
ToppCellIPF-Epithelial-Ciliated|Epithelial / Disease state, Lineage and Cell class

CFAP251 AK9 DNAH7 DMD DNAH5

9.84e-051931065ad58f5080e0ba65c845056ea6b79037b636e9c64
ToppCellsevere-low-quality_cells|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

TNIK SLC4A7 FNBP1L LRBA VPS13B

9.84e-0519310659337bc93e3904c7fc7c93c328518bcd6453b1e8c
ToppCellBronchial_Biopsy-Epithelial-Ciliated_1|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

CFAP251 AK9 DNAH7 DNAH5 CFAP157

9.84e-0519310650b62a6ddd7c42efd9f39781971d1438501e1fa8d
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CFAP251 ADAMTS2 ATP10D PDLIM1 DMD

9.84e-0519310655b602b1702283184bd3943c2a6f2290b7c37e407
ToppCellASK440-Epithelial-Ciliated|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq

CFAP251 AGR2 DNAH7 DNAH5 CFAP157

9.84e-051931065a0baa8be6f590b2031fede22be588715ae458e93
ToppCellCOVID-19-kidney-FLT1+PLVAP+EC|kidney / Disease (COVID-19 only), tissue and cell type

SLC4A7 ARID5A PDLIM1 TNS1 SH3RF3

9.84e-051931065479abb1cd2eb978b8a4fdb900069a6329fc8cade
ToppCellBronchial_Brush-Epithelial-Ciliated_1|Bronchial_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X

CFAP251 AK9 DNAH7 DNAH5 CFAP157

1.01e-041941065b4ce60c06568123008b1081d644733cb91c28f51
ToppCellBronchial_Brush-Epithelial-Ciliated_1|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

CFAP251 AK9 DNAH7 DNAH5 CFAP157

1.01e-0419410657a7ddccfe72a4a0dc4d1a5c809988f0069f9f1a3
ToppCellwk_15-18-Epithelial-Proximal_epithelial|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

CFAP251 AGR2 DNAH7 DNAH5 CFAP157

1.01e-041941065b0477583301dc6d9767b667bd2f8f94fbfaa6f81
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CFAP251 AK9 DNAH7 DNAH5 CFAP157

1.01e-0419410654a2c127c90d1fefe604fcb9e796577d21b489dd6
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CFAP251 AK9 DNAH7 DNAH5 CFAP157

1.03e-0419510650e763f36786515698b593e5c93f6a56619c1242d
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CFAP251 AK9 DNAH7 DNAH5 CFAP157

1.03e-041951065581b04220587e1d5198b1abd6965965ace7803e7
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CFAP251 AK9 DNAH7 DNAH5 CFAP157

1.03e-04195106593b1559382a12cfb158aa5fac7386e38b4f87989
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

RHOBTB3 FNBP1L GTF2IRD1 DNAH7 LRBA

1.03e-0419510656477e6e7be5bd8eb99119a12ae16334ccddecd43
ToppCellControl_saline-Epithelial_airway-airway_epithelial-Ciliated|Control_saline / Treatment groups by lineage, cell group, cell type

AGR2 AK9 DNAH7 DNAH5 CFAP157

1.03e-04195106560067b5359174f0d1a8b5748bfc0690762e9e740
ToppCellBronchial-NucSeq|Bronchial / Cell types per location group and 10X technology with lineage, and cell group designations

GPHN ST7 LRBA DMD VPS13B

1.06e-041961065ab53c742866945545a92e2e61850d63c80d9a2a6
ToppCellwk_08-11-Hematologic-Myeloid-Myelocyte-like|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

MALT1 AGO1 MAPK1 ATL2 ZNF700

1.06e-0419610654b88c96b737a747422674ad99c073b28e6febc7c
ToppCellfacs-Skin-Telogen-3m-Epithelial-outer_bulge|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

APLP2 FGF18 DMD TNS1 PLS3

1.06e-041961065c936014125b2ed5f796221b74acb77b8f8359875
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS2 ATP10D PDLIM1 DMD SH3RF3

1.06e-0419610653a6c942e2907aa07b5e12dbf9019d18f7bfca507
ToppCellCOVID-19_Mild-Classical_Monocyte-cMono_3|COVID-19_Mild / Disease condition and Cell class

DNAJC13 TDRD9 ADAMTS2 APLP2 VNN2

1.06e-041961065f245e929a286cb097130572e1027b4f01be8b04d
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS2 ATP10D PDLIM1 DMD SH3RF3

1.06e-041961065bba88e91cd3e3a6f5a9b443e3a4da33c5b455e70
ToppCell15-Trachea|15 / Age, Tissue, Lineage and Cell class

CFAP251 AGR2 UCP2 DNAH5 CFAP157

1.06e-041961065fd17403422cf95c24f6be1c2d78764bb352f7f2e
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLC4A7 RHOBTB3 GTF2IRD1 DNAH7 LRBA

1.06e-041961065eea66711a16134f86e6c533a5a837ff2e0d7ca7f
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SLC4A7 ADAMTS2 ATP10D DMD SH3RF3

1.08e-04197106585a8f1d18e0dd1d31341f5131eecd217553bf042
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SLC4A7 ADAMTS2 ATP10D DMD SH3RF3

1.08e-041971065e8e3ba791dfaa0fab35e0329a5e34376f9ee6143
ToppCellSevere_COVID-19-Epithelial-transitional_Epi|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）

CFAP251 AGR2 FER1L6 DNAH5 PLS3

1.08e-0419710655ad3cd4c77016e862041baac3076f8cc0f75c417
ToppCellCOVID-19-Epithelial|COVID-19 / Condition, Lineage and Cell class

AGR2 DNAH7 DNAH5 CNN3 CFAP157

1.08e-04197106518fd7344628a87d5c7ef5efb66e260a4136245bf
ToppCellControl_saline-Epithelial_airway|Control_saline / Treatment groups by lineage, cell group, cell type

AGR2 DNAH7 HSD17B2 DNAH5 CFAP157

1.11e-041981065e6863238e022ecfb6a8e3f4b7661b376e92c5d8f
ToppCellwk_20-22-Epithelial-Proximal_epithelial|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

CFAP251 AGR2 DNAH7 DNAH5 CFAP157

1.11e-04198106516c54b884500066ade05a406915f9569ca8abdfc
ToppCellcritical-Epithelial-Ciliated|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

CFAP251 AK9 DNAH7 DNAH5 CFAP157

1.11e-041981065ee2c8385c0bf4ea9f5c9517b52cf131af3fbdd40
ToppCell18-Airway|18 / Age, Tissue, Lineage and Cell class

AGR2 UCP2 DNAH5 CRISPLD1 CFAP157

1.11e-0419810653cdfcc6445858c3c54058bbd90b20b88b1771cca
ToppCellParenchymal-NucSeq|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations

GPHN ST7 LRBA DMD VPS13B

1.11e-0419810651996373bdccc55aac347d349bd22f6aad6d0c668
ToppCellControl_saline-Epithelial_airway-airway_epithelial|Control_saline / Treatment groups by lineage, cell group, cell type

AGR2 DNAH7 HSD17B2 DNAH5 CFAP157

1.11e-041981065e7aa42e5fbd42c68f50cda4a8f3aa464c862c007
ToppCellLPS_only-Epithelial_airway-airway_epithelial|LPS_only / Treatment groups by lineage, cell group, cell type

TDRD9 AGR2 DNAH7 DNAH5 CFAP157

1.11e-041981065e035380578c01b0243bfef29ca9b50cc17cce771
ToppCellLPS_only-Epithelial_airway|LPS_only / Treatment groups by lineage, cell group, cell type

TDRD9 AGR2 DNAH7 DNAH5 CFAP157

1.11e-041981065ba090210392e001a3f7bdf09371b3f0e0c8c7ef3
ToppCellLPS_only-Epithelial_airway-airway_epithelial-Ciliated|LPS_only / Treatment groups by lineage, cell group, cell type

MYO7A AK9 DNAH7 DNAH5 CFAP157

1.11e-0419810656d90b541fde357fbb40f8f7d4e8628a48b679718
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CFAP251 AGR2 DNAH7 DNAH5 CFAP157

1.11e-041981065d0ecace1fad24ce50b0935036fabb07e6c9e372d
ToppCellBAL-Mild-Epithelial-Epithelial|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

AGR2 DNAH7 DNAH5 CNN3 CFAP157

1.14e-0419910651ee4010d8557564e25e8ee00b914c2dfd9037838
ToppCellwk_20-22-Epithelial-Proximal_epithelial-Ciliated|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

CFAP251 AGR2 DNAH7 DNAH5 CFAP157

1.14e-041991065b974b495cabbcc3934936cec846c0e2442a70ac3
ToppCellmild-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

TNIK SLC4A7 ABCA5 LRBA VPS13B

1.14e-041991065f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCellBAL-Mild-Epithelial-Epithelial|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

AGR2 DNAH7 DNAH5 CNN3 CFAP157

1.14e-0419910651df69c0cb5f759f6a2152521842506a75bb95cae
ToppCellMild-Epithelial-Epithelial-|Mild / Condition, Lineage, Cell class and cell subclass

AGR2 DNAH7 DNAH5 CNN3 CFAP157

1.14e-04199106581115bbd2c10bfdd38376d2075f03a59c31870d2
ToppCellBAL-Mild-Epithelial|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

AGR2 DNAH7 DNAH5 CNN3 CFAP157

1.14e-04199106574087b4b5e567310fc4ac58fb267ff651a180680
ToppCellLPS_anti-TNF-Epithelial_airway-airway_epithelial|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

AGR2 DNAH7 VNN2 HSD17B2 DNAH5

1.14e-04199106560919c2af31d39a2d36d7bc432e43dab2a4e05fb
ToppCellLPS_anti-TNF-Epithelial_airway-airway_epithelial-Ciliated|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

SLC4A8 AGR2 AK9 DNAH7 DNAH5

1.14e-04199106515f7814b7074170eee7ccacaa670b1d128fc68bb
ToppCellBAL-Mild-Epithelial|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

AGR2 DNAH7 DNAH5 CNN3 CFAP157

1.14e-04199106500b5ce099c50a5e1786ce2b3a06ee0931a8205a4
ToppCellMild-Epithelial|Mild / Condition, Lineage, Cell class and cell subclass

AGR2 DNAH7 DNAH5 CNN3 CFAP157

1.14e-041991065ec5fff80e2a8a94fbaf1fdcc6d45c8d7c6252e18
ToppCellTracheal-NucSeq|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations

GPHN CPEB3 LRBA DMD VPS13B

1.14e-04199106594b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCellMild-Epithelial-Epithelial|Mild / Condition, Lineage, Cell class and cell subclass

AGR2 DNAH7 DNAH5 CNN3 CFAP157

1.14e-04199106591308b255783ad4029e5575028c18d7550832c51
ToppCellnormal_Pleural_Fluid-Epithelial_cells|normal_Pleural_Fluid / Location, Cell class and cell subclass

RHOBTB3 AGR2 FNBP1L PLS3 CNN3

1.14e-041991065564ba7acd03be2d6e4d0850cb2c7237a788dc275
ToppCellLPS_anti-TNF-Epithelial_airway|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

AGR2 DNAH7 VNN2 HSD17B2 DNAH5

1.14e-0419910656aca164bbbb961f34b1e6f1857f91ade5c059405
ToppCellMild_COVID-19-Epithelial|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）

AGR2 DNAH7 DNAH5 CNN3 CFAP157

1.14e-04199106572689bda7476930887ae007682fcab27f956f050
DiseaseMalignant neoplasm of breast

ABHD12B AGR2 TRMT11 CMC2 THOC5 KMT2D LRBA DMD TNS1 PLS3 TOP2A VPS13B HDLBP

8.54e-05107410213C0006142
Diseaseprostate cancer (is_marker_for)

PMS2 KMT2D MMP15 ALOX12 TOP2A

2.14e-041561025DOID:10283 (is_marker_for)
Diseasebreast cancer (is_marker_for)

PMS2 AGR2 KMT2D MAPK1 ALOX12

4.68e-041851025DOID:1612 (is_marker_for)
DiseaseMalignant mesothelioma

MLANA ADAMTS2 FGF18 AGO1

5.67e-041091024C0345967
DiseasePARKINSON DISEASE, LATE-ONSET

DNAJC13 ATXN8OS

7.64e-04121022C3160718
DiseaseCommon variable immunodeficiency

NFKB2 LRBA

9.00e-04131022cv:C0009447
DiseaseDiffuse Large B-Cell Lymphoma

RPS6KB1 MALT1 KMT2D

9.23e-04551023C0079744
Diseaseneutrophil count, basophil count

RASA2 PCDHA8 PSMD2 PCDHA6 PCGF3

1.11e-032241025EFO_0004833, EFO_0005090
Diseaseanemia (implicated_via_orthology)

SLC4A7 SLC4A8

1.21e-03151022DOID:2355 (implicated_via_orthology)
DiseaseNoonan-Like Syndrome With Loose Anagen Hair

RASA1 RASA2

1.95e-03191022C3501846
DiseaseCostello syndrome (disorder)

RASA1 RASA2

1.95e-03191022C0587248
DiseaseNoonan syndrome-like disorder with loose anagen hair

RASA1 RASA2

1.95e-03191022C1843181
DiseaseCardio-facio-cutaneous syndrome

RASA1 RASA2

1.95e-03191022C1275081
DiseaseLEOPARD Syndrome

RASA1 RASA2

2.61e-03221022C0175704
DiseaseBronchiectasis

NFKB2 DNAH5

2.61e-03221022C0006267
DiseaseNoonan Syndrome

RASA1 RASA2

3.11e-03241022C0028326
Diseasevisceral adipose tissue measurement, body mass index

ADAMTS2 PCDHA8 PCDHA6

3.44e-03871023EFO_0004340, EFO_0004765

Protein segments in the cluster

PeptideGeneStartEntry
APKVRFMTKIYHPNV

UBE2N

66

P61088
AAPKVRFMTKIYHPN

UBE2NL

66

Q5JXB2
PPYFAMENAENHKIK

ABCA5

1036

Q8WWZ7
KHLSPDGQYVPRIMF

AGR2

116

O95994
LIPRPGHQFAKYAEM

C2orf16

121

Q68DN1
GHQFAKYAEMIPQPK

C2orf16

126

Q68DN1
YKFMKERHTPIERVP

ARID5A

66

Q03989
NPRPGKMVIYDLHES

CRYBG3

2291

Q68DQ2
KYNPPDHEVVAMARK

BRD4

431

O60885
HEKPLSFNPYKMLEE

APOBEC3H

151

Q6NTF7
KERVKMVIFPPGFQH

ABHD12B

326

Q7Z5M8
MVQHFKPQIFGDRKP

AGO1

76

Q9UL18
FAKHPRMGYLPVQTV

DMD

3386

P11532
ERGYQLKPHEPMNEA

AADACL3

296

Q5VUY0
PPLAKEMKEFYHIQI

CFAP157

31

Q5JU67
RYEKMHFFNVPEPDG

ATP10D

346

Q9P241
QHFCGRRKKYMPQPP

ADAMTS16

246

Q8TE57
RSPKKHGYIKMFEIP

ADAMTS2

731

O95450
KRMPFFKKTEHTPPY

CACNB2

261

Q08289
LKVYLNHKPPFGNTM

CFAP251

1031

Q8TBY9
RKQREFYHKLGMEVP

PCGF3

91

Q3KNV8
PYMEGVNPFIKSNKH

RASA1

951

P20936
EAKNLLPYLGPHKMR

RASA2

46

Q15283
MLPPKTEQYVELHKG

GPHN

711

Q9NQX3
YKILIDATDKGHPPM

PCDHA6

316

Q9UN73
NEDTQPELYHPMKKG

APLP2

611

Q06481
KHAKFRCYVMGKPEP

OBSL1

261

O75147
NPLHFGEMKVYVIEP

NUP210

521

Q8TEM1
MDKGFPQRVVKHFPG

MMP27

406

Q9H306
MLSNRPIFPGKHYLD

MAPK1

221

P28482
YKILIDATDKGHPPM

PCDHA8

316

Q9Y5H6
VAVERNMPPLKFYHD

KIAA0100

1071

Q14667
LPYGHYSMQKKKPRE

LEXM

246

Q3ZCV2
HFYRKPSPQAEEMLK

MAD2L1BP

96

Q15013
VGKEHMFYGEPRKLL

MAGEA9

231

P43362
MPREDAHFIYGYPKK

MLANA

1

Q16655
NKIDPHAPNEMLYGR

LANCL1

141

O43813
MNYREHPKLKAPLVD

MALT1

351

Q9UDY8
FRPEPDMLYAQKAKG

ATXN8OS

106

P0DMR3
SYHEEFNPPKEPMKD

AK2

151

P54819
KFDNERLRMEPGYPK

MMP15

536

P51511
KFMVKFFPVDPGHLR

FRMD7

76

Q6ZUT3
PIKFDKILMNEGGHY

C1QTNF2

166

Q9BXJ5
FKEANMPLPGYKVRE

PLS3

41

P13797
DVHFMKRYPKGQPEL

FGF18

171

O76093
YKKQAFPMISKRPEH

RPS6KB1

506

P23443
LSVLKHMPQKYGPDA

LRBA

191

P50851
SMHARNRYKDKPPDF

METTL16

6

Q86W50
QPDMVPLGHHKEKYF

ALOX12

601

P18054
AAPIAMQIYKKHLDP

IRAK1

466

P51617
MQIYKKHLDPRPGPC

IRAK1

471

P51617
HYCMNEIKTGKPRIP

FNBP1L

361

Q5T0N5
MIRTDHEPLKGKHYP

CPEB3

356

Q8NE35
QPPNYEMLKEEHKVA

nan

16

C9JQL5
PCPEIFNMKLHYKRE

GBGT1

41

Q8N5D6
EHGIAMRKKLFNPPE

CMC2

61

Q9NRP2
NHGGYVDVMPVDKRK

CRISPLD1

456

Q9H336
YMERFGKKGKLPHQV

DNAH7

86

Q8WXX0
KIYQGEELPHPKSML

ATL2

361

Q8NHH9
YHPDKNPEGRDMFEK

DNAJC13

1331

O75165
KPPFQSGMHYVQDKL

KHDC4

221

Q7Z7F0
EEYNRHKPPKQVDIM

EEF2K

196

O00418
GGPKEALEMYRKVHN

DGKZ

331

Q13574
PVKVPYSKFLMHPEE

GTF2IRD1

586

Q9UHL9
KHRDFVAEPMGEKPV

BANF1

6

O75531
YFAKRHFGQDKPMPR

HSD17B2

361

P37059
YVPFEVKERLQKMGP

DNAH5

4371

Q8TE73
MPPEYKGHQVKEVLI

LRRN1

401

Q6UXK5
PLVTEEGKRHPYKMN

PDLIM1

91

O00151
EGKRHPYKMNLASEP

PDLIM1

96

O00151
QPEKMPVLKAEASHY

RHOBTB3

226

O94955
PFIYRLRNKDMHGAP

OR1D5

286

P58170
ETRPLYHKDKPGMEQ

FER1L6

1551

Q2WGJ9
GKMDPVAYRVKYTPH

QARS1

411

P47897
MEENKDRFPGAPKYG

AK9

616

Q5TCS8
GKRFVHVKNPYLDLM

UPP2

21

O95045
KNYPVEKMVPFLHSD

TRMT11

91

Q7Z4G4
FPKIESVHPQKYAMD

TRDMT1

186

O14717
DRIKLFGMPAKHQPD

SLC4A7

1056

Q9Y6M7
FGMPAKHQPDLIYLR

SLC4A7

1061

Q9Y6M7
KMNPAYIFEVEGKPH

TDRD9

306

Q8NDG6
MDVDKQAIYRHPLFP

PKNOX1

51

P55347
PHYGKLKEIYENMAP

PSMD2

101

Q13200
FGMPAKHQPDFIYLR

SLC4A8

931

Q2Y0W8
EFNPHVPKYLLEMKS

ST7

411

Q9NRC1
VHPKFPEGGKMSQYL

CYB5R1

121

Q9UHQ9
RLAMFPITKNHKDYP

AKR1E2

301

Q96JD6
VKPGEKHYNMAKSYP

ADAM17

291

P78536
RHLYDPKMQTDKPFD

CNN3

186

Q15417
APNGPKVYHYDMKTE

VNN2

281

O95498
LAMNYKHGDPIPKVE

TPH1

151

P17752
RPVEKKPLYHYKEGM

TNIK

511

Q9UKE5
EKHIRMPSGERPYKC

ZNF700

496

Q9H0M5
LQKEGPRAFYKGFMP

UCP2

261

P55851
LAHDEMKSPREPGYK

THRAP3

691

Q9Y2W1
FKLKPMLIYHSENPR

TIGD1

231

Q96MW7
HAPPQGKALYDFEMK

SH3RF3

256

Q8TEJ3
DGYPAFKRPHMTAKD

TEX37

66

Q96LM6
VDPKHQPAAEMAKGY

TEX37

136

Q96LM6
MKRFYEDKIVPIGQP

TNS1

146

Q9HBL0
EPKPLMFKDSYHNLR

UNC5B

741

Q8IZJ1
KKDFIMHRLPPYSAG

RIOX2

331

Q8IUF8
MFDHNGKIIQKTPYP

PMS2

136

P54278
PGKTPIQVLHEYGMK

PRKRA

31

O75569
MKRHRIQFKYSGPED

TOP2A

631

P11388
PTEDQIMHAGEKPYK

ZNF251

581

Q9BRH9
INEKMARHTKGPEFY

TEX13A

21

Q9BXU3
AGHKYMEPLQEIPFV

VPS13B

1126

Q7Z7G8
YRKPSALKFEVVHMP

UGT2A3

66

Q6UWM9
ALQVYMKPPAHEEAK

HDLBP

1206

Q00341
MYRHALPPGFVLKKD

ZC3H15

206

Q8WU90
LFRGPSRMKPFKYNH

THOC5

661

Q13769
FKPIQKEMTPHAGRY

PIFO

81

Q8TCI5
KEMTPHAGRYQKVSP

PIFO

86

Q8TCI5
KGYHTFCLKPPMEEL

KMT2D

296

O14686
EKGFNPRILYPAKMA

L1TD1

816

Q5T7N2
QYTNKKIGEMPPHIF

MYO7A

121

Q13402
AIVFRTPPYHKMKIE

NFKB2

286

Q00653