Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	minus-end-directed microtubule motor activity	DNAH3 DNAH17 DNAH9	3.53e-05	18	72	3	GO:0008569
GeneOntologyMolecularFunction	dynein light intermediate chain binding	DNAH3 DNAH17 DNAH9	1.38e-04	28	72	3	GO:0051959
GeneOntologyMolecularFunction	cysteine-type endopeptidase activity	USP34 USP7 USP20 USP33	2.64e-04	86	72	4	GO:0004197
GeneOntologyMolecularFunction	dynein intermediate chain binding	DNAH3 DNAH17 DNAH9	3.20e-04	37	72	3	GO:0045505
GeneOntologyMolecularFunction	cysteine-type deubiquitinase activity	USP34 USP7 USP20 USP33	7.69e-04	114	72	4	GO:0004843
GeneOntologyMolecularFunction	nuclear export signal receptor activity	RANBP17 XPO7	8.27e-04	12	72	2	GO:0005049
GeneOntologyMolecularFunction	deubiquitinase activity	USP34 USP7 USP20 USP33	1.05e-03	124	72	4	GO:0101005
GeneOntologyCellularComponent	cell cortex	SEPTIN14 PDE4DIP MACF1 TNFAIP2 CAPZA3 SEPTIN12 PDZD4 EXOC4	4.96e-05	371	74	8	GO:0005938
GeneOntologyCellularComponent	axonemal dynein complex	DNAH3 DNAH17 DNAH9	9.26e-05	25	74	3	GO:0005858
GeneOntologyCellularComponent	outer dynein arm	DNAH17 DNAH9	7.97e-04	12	74	2	GO:0036157
GeneOntologyCellularComponent	dynein complex	DNAH3 DNAH17 DNAH9	9.28e-04	54	74	3	GO:0030286
GeneOntologyCellularComponent	septin complex	SEPTIN14 SEPTIN12	1.09e-03	14	74	2	GO:0031105
GeneOntologyCellularComponent	septin ring	SEPTIN14 SEPTIN12	1.09e-03	14	74	2	GO:0005940
GeneOntologyCellularComponent	septin cytoskeleton	SEPTIN14 SEPTIN12	1.44e-03	16	74	2	GO:0032156
GeneOntologyCellularComponent	motile cilium	WDR19 DNAH3 DNAH17 DNAH9 AK7 SEPTIN12	1.61e-03	355	74	6	GO:0031514
HumanPheno	Abnormal sperm motility	WDR19 DNAH17 DNAH9 ODAD3 AK7 SEPTIN12	1.85e-05	115	26	6	HP:0012206
HumanPheno	Abnormal sperm physiology	WDR19 DNAH17 DNAH9 ODAD3 AK7 SEPTIN12	1.85e-05	115	26	6	HP:0034809
HumanPheno	Male infertility	WDR19 DNAH17 TEX11 DNAH9 ODAD3 AK7 SEPTIN12	5.98e-05	209	26	7	HP:0003251
HumanPheno	Infertility	WDR19 DNAH17 TEX11 NLRP2 DNAH9 ODAD3 AK7 SEPTIN12	1.12e-04	314	26	8	HP:0000789
HumanPheno	Decreased fertility in males	WDR19 DNAH17 TEX11 DNAH9 ODAD3 AK7 SEPTIN12	1.29e-04	236	26	7	HP:0012041
Domain	Rb_C	RB1 RBL1	1.47e-05	2	72	2	PF08934
Domain	-	DNAH3 NWD1 SETX ERAL1 CHST4 SEPTIN14 RNF213 CHD3 NLRP2 DNAH9 AK7 SEPTIN12	2.56e-05	746	72	12	3.40.50.300
Domain	RB_A	RB1 RBL1	4.39e-05	3	72	2	IPR002720
Domain	DUF3452	RB1 RBL1	4.39e-05	3	72	2	PF11934
Domain	RB_B	RB1 RBL1	4.39e-05	3	72	2	IPR002719
Domain	RB_A	RB1 RBL1	4.39e-05	3	72	2	PF01858
Domain	RB_B	RB1 RBL1	4.39e-05	3	72	2	PF01857
Domain	RB_C	RB1 RBL1	4.39e-05	3	72	2	IPR015030
Domain	RB_fam	RB1 RBL1	4.39e-05	3	72	2	IPR028309
Domain	DUF3452	RB1 RBL1	4.39e-05	3	72	2	SM01367
Domain	Rb_C	RB1 RBL1	4.39e-05	3	72	2	SM01369
Domain	RB_A	RB1 RBL1	4.39e-05	3	72	2	SM01368
Domain	RB_N	RB1 RBL1	4.39e-05	3	72	2	IPR024599
Domain	P-loop_NTPase	DNAH3 NWD1 SETX ERAL1 CHST4 SEPTIN14 RNF213 CHD3 NLRP2 DNAH9 AK7 SEPTIN12	8.85e-05	848	72	12	IPR027417
Domain	USP_CS	USP34 USP7 USP20 USP33	1.22e-04	66	72	4	IPR018200
Domain	USP_1	USP34 USP7 USP20 USP33	1.54e-04	70	72	4	PS00972
Domain	UCH	USP34 USP7 USP20 USP33	1.62e-04	71	72	4	PF00443
Domain	USP_2	USP34 USP7 USP20 USP33	1.62e-04	71	72	4	PS00973
Domain	USP_3	USP34 USP7 USP20 USP33	1.71e-04	72	72	4	PS50235
Domain	USP_dom	USP34 USP7 USP20 USP33	1.71e-04	72	72	4	IPR028889
Domain	Peptidase_C19_UCH	USP34 USP7 USP20 USP33	1.71e-04	72	72	4	IPR001394
Domain	DUSP	USP20 USP33	2.18e-04	6	72	2	SM00695
Domain	DUSP	USP20 USP33	2.18e-04	6	72	2	PF06337
Domain	-	USP20 USP33	3.04e-04	7	72	2	3.30.2230.10
Domain	DUSP	USP20 USP33	3.04e-04	7	72	2	PS51283
Domain	Pept_C19_DUSP	USP20 USP33	3.04e-04	7	72	2	IPR006615
Domain	ZnF_UBP	USP20 USP33	7.88e-04	11	72	2	SM00290
Domain	Septin	SEPTIN14 SEPTIN12	1.11e-03	13	72	2	PF00735
Domain	G_SEPTIN_dom	SEPTIN14 SEPTIN12	1.11e-03	13	72	2	IPR030379
Domain	G_SEPTIN	SEPTIN14 SEPTIN12	1.11e-03	13	72	2	PS51719
Domain	Dynein_heavy_chain_D4_dom	DNAH3 DNAH9	1.29e-03	14	72	2	IPR024317
Domain	Dynein_HC_stalk	DNAH3 DNAH9	1.29e-03	14	72	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH3 DNAH9	1.29e-03	14	72	2	IPR013602
Domain	Znf_UBP	USP20 USP33	1.29e-03	14	72	2	IPR001607
Domain	DHC_N2	DNAH3 DNAH9	1.29e-03	14	72	2	PF08393
Domain	MT	DNAH3 DNAH9	1.29e-03	14	72	2	PF12777
Domain	AAA_8	DNAH3 DNAH9	1.29e-03	14	72	2	PF12780
Domain	ATPase_dyneun-rel_AAA	DNAH3 DNAH9	1.29e-03	14	72	2	IPR011704
Domain	zf-UBP	USP20 USP33	1.29e-03	14	72	2	PF02148
Domain	ZF_UBP	USP20 USP33	1.29e-03	14	72	2	PS50271
Domain	Septin	SEPTIN14 SEPTIN12	1.29e-03	14	72	2	IPR016491
Domain	AAA_5	DNAH3 DNAH9	1.29e-03	14	72	2	PF07728
Domain	DHC_fam	DNAH3 DNAH9	1.49e-03	15	72	2	IPR026983
Domain	IBN_N	RANBP17 XPO7	1.49e-03	15	72	2	PF03810
Domain	Dynein_heavy_dom	DNAH3 DNAH9	1.49e-03	15	72	2	IPR004273
Domain	Dynein_heavy	DNAH3 DNAH9	1.49e-03	15	72	2	PF03028
Domain	Pkinase_Tyr	TYRO3 MST1R NPR1 ALK	1.55e-03	129	72	4	PF07714
Domain	IBN_N	RANBP17 XPO7	1.70e-03	16	72	2	SM00913
Domain	Importin-beta_N	RANBP17 XPO7	1.92e-03	17	72	2	IPR001494
Domain	ARM-type_fold	DOCK3 RANBP17 USP34 VAC14 UTP20 XPO7	1.95e-03	339	72	6	IPR016024
Domain	Ser-Thr/Tyr_kinase_cat_dom	TYRO3 MST1R NPR1 ALK	1.99e-03	138	72	4	IPR001245
Domain	ARM-like	RANBP17 VAC14 SETX UTP20 XPO7	3.87e-03	270	72	5	IPR011989
Domain	TyrKc	TYRO3 MST1R ALK	4.77e-03	88	72	3	SM00219
Domain	Tyr_kinase_cat_dom	TYRO3 MST1R ALK	4.77e-03	88	72	3	IPR020635
Domain	Kinase-like_dom	TYRO3 MST1R NPR1 WDR81 MACF1 ALK DYRK3	4.82e-03	542	72	7	IPR011009
Domain	WD40_repeat_dom	WDR19 KNTC1 NWD1 WDR81 SEC31A	5.77e-03	297	72	5	IPR017986
Domain	PROTEIN_KINASE_TYR	TYRO3 MST1R ALK	6.25e-03	97	72	3	PS00109
Domain	Tyr_kinase_AS	TYRO3 MST1R ALK	6.25e-03	97	72	3	IPR008266
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	DOCK3 KNTC1 ATP8B4 DNAH17 RNF213 MACF1 TTC39A USP20 EXOC4	1.18e-06	493	75	9	15368895
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	WDR19 DOCK3 USP34 FBXL16 P4HTM PDE9A PDE4DIP USP7 MACF1 SEC31A ZBTB11 USP33 EXOC4	3.39e-06	1285	75	13	35914814
Pubmed	GRPR/Extracellular Signal-Regulated Kinase and NPRA/Extracellular Signal-Regulated Kinase Signaling Pathways Play a Critical Role in Spinal Transmission of Chronic Itch.	NPR1 GRPR	4.59e-06	2	75	2	33039402
Pubmed	Interaction of mouse adenovirus type 1 early region 1A protein with cellular proteins pRb and p107.	RB1 RBL1	4.59e-06	2	75	2	8862413
Pubmed	Rb and p107 regulate preadipocyte differentiation into white versus brown fat through repression of PGC-1alpha.	RB1 RBL1	4.59e-06	2	75	2	16271529
Pubmed	Retinoblastoma susceptibility gene product (pRb) and p107 functionally separate the requirements for serum and anchorage in the cell cycle G1-phase.	RB1 RBL1	4.59e-06	2	75	2	14732703
Pubmed	Fusion of the SEC31L1 and ALK genes in an inflammatory myofibroblastic tumor.	SEC31A ALK	4.59e-06	2	75	2	16161041
Pubmed	Identification of a novel putative Ran-binding protein and its close homologue.	RANBP17 XPO7	4.59e-06	2	75	2	11071879
Pubmed	Susceptibility of pRb-deficient epidermis to chemical skin carcinogenesis is dependent on the p107 allele dosage.	RB1 RBL1	4.59e-06	2	75	2	18300254
Pubmed	Human papillomavirus type 16 E7 associates with a histone H1 kinase and with p107 through sequences necessary for transformation.	RB1 RBL1	4.59e-06	2	75	2	8386265
Pubmed	p107 regulates neural precursor cells in the mammalian brain.	RB1 RBL1	4.59e-06	2	75	2	15353549
Pubmed	p107 is a suppressor of retinoblastoma development in pRb-deficient mice.	RB1 RBL1	4.59e-06	2	75	2	9620848
Pubmed	Spinal GRPR and NPRA Contribute to Chronic Itch in a Murine Model of Allergic Contact Dermatitis.	NPR1 GRPR	4.59e-06	2	75	2	32032577
Pubmed	A novel tumor suppressor network in squamous malignancies.	RB1 RBL1	4.59e-06	2	75	2	23145321
Pubmed	Rb and p107 are required for alpha cell survival, beta cell cycle control and glucagon-like peptide-1 action.	RB1 RBL1	4.59e-06	2	75	2	25249236
Pubmed	Reversal of terminal differentiation mediated by p107 in Rb-/- muscle cells.	RB1 RBL1	4.59e-06	2	75	2	8197461
Pubmed	Deubiquitinases USP20/33 promote the biogenesis of tail-anchored membrane proteins.	USP20 USP33	4.59e-06	2	75	2	33792613
Pubmed	Retinoblastoma family proteins have distinct functions in pulmonary epithelial cells in vivo critical for suppressing cell growth and tumorigenesis.	RB1 RBL1	1.37e-05	3	75	2	19887614
Pubmed	Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry.	RB1 RBL1	1.37e-05	3	75	2	12853964
Pubmed	The retinoblastoma protein and its homolog p130 regulate the G1/S transition in pancreatic beta-cells.	RB1 RBL1	1.37e-05	3	75	2	19509021
Pubmed	Identification of novel fusion partners of ALK, the anaplastic lymphoma kinase, in anaplastic large-cell lymphoma and inflammatory myofibroblastic tumor.	RNF213 ALK	1.37e-05	3	75	2	12112524
Pubmed	p130/p107/p105Rb-dependent transcriptional repression during DNA-damage-induced cell-cycle exit at G2.	RB1 RBL1	1.37e-05	3	75	2	15827088
Pubmed	Differentiated horizontal interneurons clonally expand to form metastatic retinoblastoma in mice.	RB1 RBL1	1.37e-05	3	75	2	17956737
Pubmed	The retinoblastoma protein, RB, is required for gastrointestinal endocrine cells to exit the cell cycle, but not for hormone expression.	RB1 RBL1	1.37e-05	3	75	2	17936268
Pubmed	Retinoblastoma protein (pRb), but not p107 or p130, is required for maintenance of enterocyte quiescence and differentiation in small intestine.	RB1 RBL1	1.37e-05	3	75	2	18981186
Pubmed	pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes.	RB1 RBL1	1.37e-05	3	75	2	9192872
Pubmed	Targeting the p53 pathway in retinoblastoma with subconjunctival Nutlin-3a.	RB1 RBL1	1.37e-05	3	75	2	21515735
Pubmed	Oxidative stress induces protein phosphatase 2A-dependent dephosphorylation of the pocket proteins pRb, p107, and p130.	RB1 RBL1	1.37e-05	3	75	2	12621062
Pubmed	Regulation of RB transcription in vivo by RB family members.	RB1 RBL1	1.37e-05	3	75	2	20100864
Pubmed	Activation of NF-kB pathway by virus infection requires Rb expression.	RB1 RBL1	1.37e-05	3	75	2	19649275
Pubmed	Rb1 and Pten Co-Deletion in Osteoblast Precursor Cells Causes Rapid Lipoma Formation in Mice.	RB1 RBL1	1.37e-05	3	75	2	26317218
Pubmed	Unique and overlapping functions of pRb and p107 in the control of proliferation and differentiation in epidermis.	RB1 RBL1	1.37e-05	3	75	2	15148303
Pubmed	Deubiquitination of type 2 iodothyronine deiodinase by von Hippel-Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation.	USP20 USP33	1.37e-05	3	75	2	12865408
Pubmed	Targeted disruption of p107: functional overlap between p107 and Rb.	RB1 RBL1	1.37e-05	3	75	2	8682293
Pubmed	Ablation of the retinoblastoma gene family deregulates G(1) control causing immortalization and increased cell turnover under growth-restricting conditions.	RB1 RBL1	1.37e-05	3	75	2	11114893
Pubmed	Targeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalization.	RB1 RBL1	1.37e-05	3	75	2	11114892
Pubmed	A-type lamins regulate retinoblastoma protein function by promoting subnuclear localization and preventing proteasomal degradation.	RB1 RBL1	1.37e-05	3	75	2	15210943
Pubmed	Monoallelic but not biallelic loss of Dicer1 promotes tumorigenesis in vivo.	RB1 RBL1	1.37e-05	3	75	2	20019750
Pubmed	Neuronal differentiation and synaptogenesis in retinoblastoma.	RB1 RBL1	1.37e-05	3	75	2	17363591
Pubmed	Aberrant anaplastic lymphoma kinase activity induces a p53 and Rb-dependent senescence-like arrest in the absence of detectable p53 stabilization.	RB1 ALK	1.37e-05	3	75	2	21423761
Pubmed	Animal models in retinoblastoma research.	RB1 RBL1	1.37e-05	3	75	2	24227978
Pubmed	p107 acts as a tumor suppressor in pRb-deficient epidermis.	RB1 RBL1	1.37e-05	3	75	2	17932945
Pubmed	A role for the Rb family of proteins in controlling telomere length.	RB1 RBL1	1.37e-05	3	75	2	12379853
Pubmed	Ablating all three retinoblastoma family members in mouse lung leads to neuroendocrine tumor formation.	RB1 RBL1	1.37e-05	3	75	2	27966456
Pubmed	Mouse fibroblasts lacking RB1 function form spheres and undergo reprogramming to a cancer stem cell phenotype.	RB1 RBL1	1.37e-05	3	75	2	19341623
Pubmed	The first knockout mouse model of retinoblastoma.	RB1 RBL1	1.37e-05	3	75	2	15190215
Pubmed	Characterization of Mayven, a novel actin-binding protein predominantly expressed in brain.	KLHL2 NPY1R	1.37e-05	3	75	2	10397770
Pubmed	Whole-exome mutational landscape of neuroendocrine carcinomas of the gallbladder.	RB1 ALK	1.37e-05	3	75	2	33563892
Pubmed	Retinoblastoma/p107/p130 pocket proteins: protein dynamics and interactions with target gene promoters.	RB1 RBL1	1.37e-05	3	75	2	19279001
Pubmed	Identification of a deubiquitinating enzyme subfamily as substrates of the von Hippel-Lindau tumor suppressor.	USP20 USP33	1.37e-05	3	75	2	12056827
Pubmed	The retinoblastoma gene family is differentially expressed during embryogenesis.	RB1 RBL1	1.37e-05	3	75	2	9150384
Pubmed	Cross-species genomic and epigenomic landscape of retinoblastoma.	RB1 RBL1	1.37e-05	3	75	2	23765217
Pubmed	Expression of the retinoblastoma family of tumor suppressors during murine embryonic orofacial development.	RB1 RBL1	1.37e-05	3	75	2	12627794
Pubmed	Interaction between human cyclin A and adenovirus E1A-associated p107 protein.	RB1 RBL1	1.37e-05	3	75	2	1532458
Pubmed	Genes in the RB pathway and their knockout in mice.	RB1 RBL1	1.37e-05	3	75	2	9110405
Pubmed	pRB plays an essential role in cell cycle arrest induced by DNA damage.	RB1 RBL1	1.37e-05	3	75	2	9751770
Pubmed	Identification of RANBP16 and RANBP17 as novel interaction partners for the bHLH transcription factor E12.	RANBP17 XPO7	1.37e-05	3	75	2	20503194
Pubmed	The retinoblastoma gene family in differentiation and development.	RB1 RBL1	1.37e-05	3	75	2	10630640
Pubmed	Changes in retinoblastoma cell adhesion associated with optic nerve invasion.	RB1 RBL1	1.37e-05	3	75	2	19786571
Pubmed	A critical temporal requirement for the retinoblastoma protein family during neuronal determination.	RB1 RBL1	1.37e-05	3	75	2	9508781
Pubmed	Unique impact of RB loss on hepatic proliferation: tumorigenic stresses uncover distinct pathways of cell cycle control.	RB1 RBL1	1.37e-05	3	75	2	19887370
Pubmed	Simultaneous depletion of RB, RBL1 and RBL2 affects endoderm differentiation of human embryonic stem cells.	RB1 RBL1	1.37e-05	3	75	2	36413521
Pubmed	Inactivating all three rb family pocket proteins is insufficient to initiate cervical cancer.	RB1 RBL1	1.37e-05	3	75	2	22942253
Pubmed	HAUSP, a novel deubiquitinase for Rb - MDM2 the critical regulator.	RB1 USP7	1.37e-05	3	75	2	24823443
Pubmed	Pocket proteins suppress head and neck cancer.	RB1 RBL1	1.37e-05	3	75	2	22237625
Pubmed	Cell-specific effects of RB or RB/p107 loss on retinal development implicate an intrinsically death-resistant cell-of-origin in retinoblastoma.	RB1 RBL1	1.37e-05	3	75	2	15193257
Pubmed	Ubiquitin-specific peptidase 20 targets TRAF6 and human T cell leukemia virus type 1 tax to negatively regulate NF-kappaB signaling.	USP20 USP33	2.75e-05	4	75	2	21525354
Pubmed	Ras protects Rb family null fibroblasts from cell death: a role for AP-1.	RB1 RBL1	2.75e-05	4	75	2	14688262
Pubmed	Coexpression of normally incompatible developmental pathways in retinoblastoma genesis.	RB1 RBL1	2.75e-05	4	75	2	21840489
Pubmed	Hematopoietic stem cell quiescence is maintained by compound contributions of the retinoblastoma gene family.	RB1 RBL1	2.75e-05	4	75	2	18940733
Pubmed	Skip interacts with the retinoblastoma tumor suppressor and inhibits its transcriptional repression activity.	RB1 RBL1	2.75e-05	4	75	2	12466551
Pubmed	A dynamic equilibrium between CDKs and PP2A modulates phosphorylation of pRB, p107 and p130.	RB1 RBL1	2.75e-05	4	75	2	15467457
Pubmed	Inhibition of a G9a/DNMT network triggers immune-mediated bladder cancer regression.	RB1 RBL1	2.75e-05	4	75	2	31270502
Pubmed	Prohibitin, a potential tumor suppressor, interacts with RB and regulates E2F function.	RB1 RBL1	2.75e-05	4	75	2	10376528
Pubmed	Pten and p53 Loss in the Mouse Lung Causes Adenocarcinoma and Sarcomatoid Carcinoma.	RB1 RBL1	2.75e-05	4	75	2	35954335
Pubmed	The retinoblastoma family proteins bind to and activate diacylglycerol kinase zeta.	RB1 RBL1	2.75e-05	4	75	2	16286473
Pubmed	Disruption of BRCA1 LXCXE motif alters BRCA1 functional activity and regulation of RB family but not RB protein binding.	RB1 RBL1	2.75e-05	4	75	2	11521194
Pubmed	Molecular cloning and characterization of a novel retinoblastoma-binding protein.	RB1 RBL1	2.75e-05	4	75	2	9721205
Pubmed	High incidence of HPV-associated head and neck cancers in FA deficient mice is associated with E7's induction of DNA damage through its inactivation of pocket proteins.	RB1 RBL1	2.75e-05	4	75	2	24086435
Pubmed	Deacetylation of the retinoblastoma tumour suppressor protein by SIRT1.	RB1 RBL1	2.75e-05	4	75	2	17620057
Pubmed	Critical role of the Rb family in myoblast survival and fusion.	RB1 RBL1	2.75e-05	4	75	2	21423694
Pubmed	Structural and functional characterization of the HPV16 E7 protein expressed in bacteria.	RB1 RBL1	2.75e-05	4	75	2	8245034
Pubmed	Differential development of large-cell neuroendocrine or small-cell lung carcinoma upon inactivation of 4 tumor suppressor genes.	RB1 RBL1	2.75e-05	4	75	2	31611390
Pubmed	Rb and p107 are required for normal cerebellar development and granule cell survival but not for Purkinje cell persistence.	RB1 RBL1	2.75e-05	4	75	2	12810584
Pubmed	A mouse model of MYCN-driven retinoblastoma reveals MYCN-independent tumor reemergence.	RB1 RBL1	2.75e-05	4	75	2	28165337
Pubmed	Rb deletion in mouse mammary progenitors induces luminal-B or basal-like/EMT tumor subtypes depending on p53 status.	RB1 RBL1	2.75e-05	4	75	2	20679727
Pubmed	Cooperation between Rb and Arf in suppressing mouse retinoblastoma.	RB1 RBL1	2.75e-05	4	75	2	22484813
Pubmed	Rb1/Rbl1/Vhl loss induces mouse subretinal angiomatous proliferation and hemangioblastoma.	RB1 RBL1	2.75e-05	4	75	2	31613797
Pubmed	Folliculin variants linked to Birt-Hogg-Dubé syndrome are targeted for proteasomal degradation.	FNIP2 USP7	2.75e-05	4	75	2	33137092
Pubmed	Id2 is a retinoblastoma protein target and mediates signalling by Myc oncoproteins.	RB1 RBL1	2.75e-05	4	75	2	11034201
Pubmed	High incidence of female reproductive tract cancers in FA-deficient HPV16-transgenic mice correlates with E7's induction of DNA damage response, an activity mediated by E7's inactivation of pocket proteins.	RB1 RBL1	2.75e-05	4	75	2	24013229
Pubmed	Differential specificity for binding of retinoblastoma binding protein 2 to RB, p107, and TATA-binding protein.	RB1 RBL1	2.75e-05	4	75	2	7935440
Pubmed	B-Myb overcomes a p107-mediated cell proliferation block by interacting with an N-terminal domain of p107.	RB1 RBL1	2.75e-05	4	75	2	12439743
Pubmed	The deubiquitinases USP33 and USP20 coordinate beta2 adrenergic receptor recycling and resensitization.	USP20 USP33	2.75e-05	4	75	2	19424180
Pubmed	The lymphoma-associated NPM-ALK oncogene elicits a p16INK4a/pRb-dependent tumor-suppressive pathway.	RB1 ALK	2.75e-05	4	75	2	21518927
Pubmed	Negative regulation of DNA replication by the retinoblastoma protein is mediated by its association with MCM7.	RB1 RBL1	2.75e-05	4	75	2	9566894
Pubmed	LEK1 is a potential inhibitor of pocket protein-mediated cellular processes.	RB1 RBL1	2.75e-05	4	75	2	14555653
Pubmed	In vivo disruption of an Rb-E2F-Ezh2 signaling loop causes bladder cancer.	RB1 RBL1	2.75e-05	4	75	2	25252918
Pubmed	Melanocyte transformation requires complete loss of all pocket protein function via a mechanism that mitigates the need for MAPK pathway activation.	RB1 RBL1	2.75e-05	4	75	2	28192409
Pubmed	Loss of pRB and p107 disrupts cartilage development and promotes enchondroma formation.	RB1 RBL1	2.75e-05	4	75	2	23146901
Interaction	NPTN interactions	CERS5 RANBP17 KNTC1 VAC14 SETX RNF213 UTP20 TNFAIP2 XPO7	8.02e-07	278	74	9	int:NPTN
Interaction	GPR17 interactions	KNTC1 VAC14 SETX RNF213 UTP20 TNFAIP2 USP33 EXOC4 XPO7	9.30e-07	283	74	9	int:GPR17
Interaction	CD80 interactions	KNTC1 VAC14 USP7 UTP20 XPO7	1.06e-05	79	74	5	int:CD80
Interaction	LIN37 interactions	RB1 RBL1 PDE4DIP CHD3 TEX11	2.35e-05	93	74	5	int:LIN37
Interaction	GYPA interactions	KNTC1 SETX RB1 UTP20 TTC39A XPO7	4.33e-05	174	74	6	int:GYPA
Interaction	GCGR interactions	CERS5 KNTC1 SETX RNF213 USP33	5.28e-05	110	74	5	int:GCGR
Interaction	USP28 interactions	KLHL2 USP7 OSBP2 USP20 USP33	6.00e-05	113	74	5	int:USP28
Cytoband	Ensembl 112 genes in cytogenetic band chr3q12	TMEM45A TMEM30CP ZBTB11	9.78e-05	54	75	3	chr3q12
Cytoband	16p13.3	C16orf90 FBXL16 USP7 SEPTIN12	7.04e-04	244	75	4	16p13.3
Cytoband	Ensembl 112 genes in cytogenetic band chr4q32	FNIP2 KLHL2 NPY1R	1.03e-03	120	75	3	chr4q32
Cytoband	14q32.2	SETD3 AK7	1.78e-03	38	75	2	14q32.2
GeneFamily	Dyneins, axonemal	DNAH3 DNAH17 DNAH9	1.32e-05	17	50	3	536
GeneFamily	Ubiquitin specific peptidases	USP34 USP7 USP20 USP33	1.71e-05	56	50	4	366
GeneFamily	Receptor Tyrosine Kinases\|CD molecules	TYRO3 MST1R ALK	1.83e-04	40	50	3	321
GeneFamily	Septins	SEPTIN14 SEPTIN12	5.73e-04	13	50	2	732
Coexpression	HOEBEKE_LYMPHOID_STEM_CELL_UP	KNTC1 USP34 MACF1 CHD3 TNFAIP2	8.80e-06	97	75	5	M14698
Coexpression	GSE13522_CTRL_VS_T_CRUZI_BRAZIL_STRAIN_INF_SKIN_DN	ATP8B4 FBXL16 RB1 DNAH17 USP7 PDZD4	2.31e-05	199	75	6	M2921
Coexpression	GSE22886_NAIVE_TCELL_VS_NEUTROPHIL_DN	RAPGEF5 CHST4 DPEP3 TTC39A TNFAIP2 DYRK3	2.31e-05	199	75	6	M4474
ToppCell	Control-Epithelial_airway-Ciliated_cells-Ciliated\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DNAH3 NWD1 DNAH9 ODAD3 AK7	6.26e-06	154	75	5	4e3bc24043144143842627cacf6f90dda2228910
ToppCell	Control-Epithelial_airway-Ciliated_cells\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DNAH3 NWD1 DNAH9 ODAD3 AK7	6.26e-06	154	75	5	7556a4b2b062da5ae7ec2bbb66e745e7662db628
ToppCell	LPS-IL1RA+antiTNF-Epithelial_airway-Ciliated_cells\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DNAH3 NWD1 DNAH9 ODAD3 AK7	6.46e-06	155	75	5	5f1e2195a6b831e1b636f5cc3a282ca423721822
ToppCell	LPS-IL1RA+antiTNF-Epithelial_airway-Ciliated_cells-Ciliated\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DNAH3 NWD1 DNAH9 ODAD3 AK7	6.46e-06	155	75	5	0944429459f642a1bcc56edc1ec28aaecde3e2dc
ToppCell	droplet-Lung-LUNG-30m-Epithelial-club_cell_of_bronchiole\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TYRO3 ASGR2 DNAH9 ODAD3 AK7	1.23e-05	177	75	5	7ac99ff16df94b4e08d361e3d98a7b3af8d6ee3b
ToppCell	droplet-Lung-LUNG-30m-Epithelial-Club_Cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TYRO3 ASGR2 DNAH9 ODAD3 AK7	1.23e-05	177	75	5	092a345cb802f183322aa5542341ba2d96d4f06a
ToppCell	Fetal_29-31_weeks-Epithelial-ciliated_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	DNAH3 NWD1 DNAH9 ODAD3 AK7	1.26e-05	178	75	5	de5d50d7ca9ee9eb62f50c88a0c6d47f0694b2e6
ToppCell	Children_(3_yrs)-Epithelial-ciliated_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	DNAH3 NWD1 DNAH9 ODAD3 AK7	1.48e-05	184	75	5	5daff849625f2f41d56615569c0ed59cd733b34c
ToppCell	CV-Moderate-7\|Moderate / Virus stimulation, Condition and Cluster	KNTC1 ATP8B4 RNF213 MACF1 EXOC4	1.52e-05	185	75	5	a6c9203ce6c2892a4a369c9bcfb85720f01cbb3f
ToppCell	Adult-Epithelial-ciliated_cell-D175\|Adult / Lineage, Cell type, age group and donor	DNAH3 NWD1 DNAH9 ODAD3 AK7	1.52e-05	185	75	5	30f4980dee6cd5959655f8d74049f3bfb5312611
ToppCell	Fetal_29-31_weeks-Epithelial-ciliated_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	DNAH3 NWD1 DNAH9 ODAD3 AK7	1.52e-05	185	75	5	3e39a3cb534dfe2301930f3e2f7e8cefb522c158
ToppCell	TCGA-Kidney-Primary_Tumor-Renal_Cell_Carcinoma-Kidney_Papillary_Renal_Cell_Carcinoma\|TCGA-Kidney / Sample_Type by Project: Shred V9	KCNV1 VAC14 P4HTM ERAL1 NPAS2	1.52e-05	185	75	5	46f4f6f20b1e152922f6f2ba1244c56e48a49b79
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	KCNV1 TYRO3 KLHL2 RAPGEF5 CLSTN2	1.56e-05	186	75	5	84ba666237c18189d7e7556bd92dd953af733c00
ToppCell	CV-Moderate-7\|CV / Virus stimulation, Condition and Cluster	KNTC1 ATP8B4 RNF213 MACF1 EXOC4	1.56e-05	186	75	5	8571956890fc9894d766ba294a28e376b4aba428
ToppCell	Ciliated-cil-2\|World / Class top	WDR19 TTC39A DNAH9 ODAD3 AK7	1.60e-05	187	75	5	e2e58ba039b5355c03c3b448e750aa37b0ea6913
ToppCell	P15-Epithelial-airway_epithelial_cell-club_cell\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	DNAH3 DNAH9 ODAD3 AK7 DYRK3	1.60e-05	187	75	5	a70aaae32426e9ddb1cbfbd0e0db24ccc96b9f40
ToppCell	P15-Epithelial-airway_epithelial_cell\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	DNAH3 DNAH9 ODAD3 AK7 DYRK3	1.64e-05	188	75	5	e3e71c0f2e374330620cb4d27638953ffa9f5298
ToppCell	PND07-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated-Ciliated_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DNAH3 TTC39A DNAH9 ODAD3 AK7	1.69e-05	189	75	5	057d7a03fdbe779122b203619a6f947f49b84d28
ToppCell	PND10-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated-Ciliated_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DNAH3 TTC39A DNAH9 ODAD3 AK7	1.69e-05	189	75	5	02c6128a9ab5818e0881dcadafdad5f08b9a67cf
ToppCell	PND10-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DNAH3 TTC39A DNAH9 ODAD3 AK7	1.69e-05	189	75	5	164ea92ff6a1aa2ead1c9b8f64f99a9d65437232
ToppCell	PND10-Epithelial-Epithelial_Airway\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DNAH3 TTC39A DNAH9 ODAD3 AK7	1.69e-05	189	75	5	407d8a59969d83f014600aae1a55092283a13970
ToppCell	PND07-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DNAH3 TTC39A DNAH9 ODAD3 AK7	1.69e-05	189	75	5	9f57a131902d23494bf389baf6e6e2d99f88b2c8
ToppCell	PND10-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DNAH3 TTC39A DNAH9 ODAD3 AK7	1.69e-05	189	75	5	a85099bd598a27ee64ee0664d051d89fa8d62fc9
ToppCell	PND07-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DNAH3 TTC39A DNAH9 ODAD3 AK7	1.69e-05	189	75	5	e443b02502edaefa94567a9e8af5756e8e11ff30
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TYRO3 KLHL2 RAPGEF5 CLSTN2 NPAS2	1.73e-05	190	75	5	49e09cdb843b3d889a06a811aa5affae68b25a75
ToppCell	PND03-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DNAH3 TTC39A DNAH9 ODAD3 AK7	1.77e-05	191	75	5	bda8faf92495c8b362850c0aff4fc6fbdd9c563b
ToppCell	PND03-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated-Ciliated_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DNAH3 TTC39A DNAH9 ODAD3 AK7	1.77e-05	191	75	5	6880fb348bb0915db9a5da4f3566ca9ff93ed258
ToppCell	CD8+_Memory_T_cell-CV-7\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	KNTC1 ATP8B4 RNF213 MACF1 EXOC4	1.77e-05	191	75	5	9454f642c3621370fa23640b631301346b300950
ToppCell	Control_saline-Epithelial_airway-airway_epithelial-Ciliated\|Control_saline / Treatment groups by lineage, cell group, cell type	DNAH3 NWD1 DNAH9 ODAD3 AK7	1.96e-05	195	75	5	60067b5359174f0d1a8b5748bfc0690762e9e740
ToppCell	severe-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	USP34 RNF213 MACF1 CHD3 TEX11	2.06e-05	197	75	5	57ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCell	Control-Control-Lymphocyte-T/NK-NK_activated\|Control / Disease, condition lineage and cell class	SETX RNF213 MACF1 DTX3L NPAS2	2.11e-05	198	75	5	76d5fe4e5bbe6c73a6ca409b80b5c3924e07cab7
ToppCell	Bronchial-NucSeq-Epithelial-Epi_airway_ciliated\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DNAH3 NWD1 DNAH9 ODAD3 AK7	2.16e-05	199	75	5	2498237b9e895ca4826a3378d9d40989968df72b
ToppCell	LPS_anti-TNF-Epithelial_airway-airway_epithelial-Ciliated\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	DNAH3 NWD1 DNAH9 ODAD3 AK7	2.16e-05	199	75	5	15f7814b7074170eee7ccacaa670b1d128fc68bb
ToppCell	Bronchial-NucSeq-Epithelial-Epi_airway_ciliated-Ciliated\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DNAH3 NWD1 DNAH9 ODAD3 AK7	2.16e-05	199	75	5	542ec45c931b40738df1f3777b00c83be33a514a
ToppCell	LPS_IL1RA-Endothelial-Endothelial\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	NPR1 SETX RAPGEF5 RNF213 MACF1	2.21e-05	200	75	5	72ea9882a8ed26fa1534aeb6ba0d1897dccc20c5
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	USP34 SETX RAPGEF5 RNF213 MACF1	2.21e-05	200	75	5	dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW26-Neuronal-GABAergic_neurons\|GW26 / Sample Type, Dataset, Time_group, and Cell type.	DOCK3 NPY1R FBXL16 PDE4DIP PDZD4	2.21e-05	200	75	5	bad32a95b759fad509401b07bc96a56687c2a592
ToppCell	LPS_IL1RA-Endothelial\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	NPR1 SETX RAPGEF5 RNF213 MACF1	2.21e-05	200	75	5	5c092b2ecc081b5d04476c56333c338cd89ab984
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	USP34 SETX RNF213 MACF1 DTX3L	2.21e-05	200	75	5	12f1685ce8f218433068e090c9d839cd5a1910bf
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-NK_activated\|COVID-19_Mild / Disease, condition lineage and cell class	SETX RNF213 MACF1 DTX3L PDZD4	2.21e-05	200	75	5	2281debd86e5d92e8fe0397aec9ef670800f7471
ToppCell	Neuronal-Excitatory\|Neuronal / cells hierarchy compared to all cells using T-Statistic	KCNV1 TYRO3 KLHL2 RAPGEF5 CLSTN2	2.21e-05	200	75	5	4409065bc7aa995354c71e0f9d6f3726cf393d6b
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Rspo4_Rxfp1_Chat\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	NPY1R IRS4 CHAT GRPR	1.05e-04	145	75	4	78f5f4b96420c7f391e4d32a9ed151ed95fad90b
ToppCell	droplet-Pancreas-Endocrine-18m-Epithelial-pancreatic_ductal_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MST1R PDE9A TMEM45A CHST4	1.11e-04	147	75	4	a5ed71afe5fcb4f541080f5552252695c7d4d090
ToppCell	LPS-antiTNF-Epithelial_airway-Ciliated_cells-Ciliated\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DNAH3 NWD1 DNAH9 AK7	1.14e-04	148	75	4	d61123f0c811287843d066b932b4a9ff09c07c5b
ToppCell	LPS-antiTNF-Epithelial_airway-Ciliated_cells\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DNAH3 NWD1 DNAH9 AK7	1.14e-04	148	75	4	c8e93b87212f55774223caa385859c566fa1981f
ToppCell	TCGA-Breast\|World / Sample_Type by Project: Shred V9	NPY1R TTC39A CLSTN2 GRPR	1.20e-04	150	75	4	08686ba1acac5c58667bf62e2af84c691d6bbdfb
ToppCell	droplet-Lung-nan-3m-Myeloid-dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KNTC1 ASGR2 TTC39A ODAD3	1.26e-04	152	75	4	77b319f594d5e4df29034bbf69c7490076f89dd3
ToppCell	LPS_only-Epithelial_airway-Ciliated_cells-Ciliated\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DNAH3 NWD1 DNAH9 ODAD3	1.33e-04	154	75	4	9ca71d440c4f87781e6525b8141e7d8d470b6a8e
ToppCell	LPS_only-Epithelial_airway-Ciliated_cells\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DNAH3 NWD1 DNAH9 ODAD3	1.33e-04	154	75	4	58072ce422d09f2de602580325eaac6c4ec6c136
ToppCell	COVID-19-kidney-Technical/muscle_(Mes)\|kidney / Disease (COVID-19 only), tissue and cell type	DNAH3 NWD1 DNAH9 ALK	1.50e-04	159	75	4	5335cbcdeaf2bbd0268bbfe0e45c8c0d288e640d
ToppCell	droplet-Lung-nan-3m-Myeloid-Proliferating_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KNTC1 ASGR2 TTC39A ODAD3	1.54e-04	160	75	4	8a7a73b0ee1877fe02d47f745d36ae2858b529e1
ToppCell	facs-Brain_Non-Myeloid-Cortex_-18m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IRS4 FBXL16 CLSTN2 NLRP2	1.58e-04	161	75	4	69f5e759c0925daa37e0177a9cc3154842906bf6
ToppCell	COVID-19-kidney-Technical/muscle_(Imm)\|kidney / Disease (COVID-19 only), tissue and cell type	DNAH3 SEPTIN14 DNAH9 ALK	1.65e-04	163	75	4	19c28ce16a588a7f4a035c32726f6ccd67702b5b
ToppCell	facs-Brain_Non-Myeloid-Cortex_-18m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IRS4 FBXL16 CLSTN2 NLRP2	1.73e-04	165	75	4	6d8b5669eee9b0903c9260fea707d186c9d7fefa
ToppCell	facs-Brain_Non-Myeloid-Cortex_-18m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IRS4 FBXL16 CLSTN2 NLRP2	1.73e-04	165	75	4	02cd87dfa2ca40e13455a4b9308477e82f76289b
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DNAH3 NWD1 SEPTIN14 DNAH9	1.81e-04	167	75	4	3edb0570e583bb527165bcd8a4c25a042054043b
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DOCK3 CHST4 CHD3 NLRP2	1.85e-04	168	75	4	de0b00bc405c898d08a06b2e585fb62c0ab9a66e
ToppCell	E16.5-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated-Ciliated_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DNAH3 DNAH9 ODAD3 AK7	1.85e-04	168	75	4	fa7c0303918cea04e3f4c4f3cb079be19004d214
ToppCell	E16.5-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DNAH3 DNAH9 ODAD3 AK7	1.85e-04	168	75	4	7edcab103c69e928d5c19a0d218ffb3ae32f9e70
ToppCell	wk_08-11-Epithelial-Proximal_epithelial-Deuterosomal\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	DNAH3 DNAH17 DNAH9 AK7	2.03e-04	172	75	4	08ad76412c9cc3504141797b44b88478ced87476
ToppCell	droplet-Lung-LUNG-1m-Myeloid-Ccr7+_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBXL16 P4HTM PDE4DIP TTC39A	2.12e-04	174	75	4	7be0c6248e77f2d0260b852b01e17892f7828f1b
ToppCell	droplet-Thymus-nan-21m-Lymphocytic-Double_negative_thymocyte,_DN3_(Cd8-,_Cd4-),_some_express_pre_TCR_alpha\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WDR19 MST1R ATP8B4 DTX3L	2.12e-04	174	75	4	a9f34d1237f335d27c5560ff514368f4709f9144
ToppCell	Globus_pallidus-Neuronal-Inhibitory-iN2(Gad1Gad2)-Inhibitory_Neuron.Gad1Gad2.Lamp5-Cplx3_(Substantia_Innominata_(SI))-\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	MST1R TMEM30CP SOWAHB	2.15e-04	69	75	3	3074ec10315fb21048215125ec08b0d7922da3d9
ToppCell	Globus_pallidus-Neuronal-Inhibitory-iN2(Gad1Gad2)-Inhibitory_Neuron.Gad1Gad2.Lamp5-Cplx3_(Substantia_Innominata_(SI))\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	MST1R TMEM30CP SOWAHB	2.15e-04	69	75	3	f731d4500b139a8bef5c9185368509bf5a3791db
ToppCell	Globus_pallidus-Neuronal-Inhibitory-iN2(Gad1Gad2)-Inhibitory_Neuron.Gad1Gad2.Lamp5-Cplx3_(Substantia_Innominata_(SI))--\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	MST1R TMEM30CP SOWAHB	2.15e-04	69	75	3	40eb84fe36da5a4a82bd9b2d962b829e2c97a059
ToppCell	droplet-Lung-1m-Hematologic-myeloid-myeloid_dendritic_cell-Ccr7+_dendritic\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FBXL16 P4HTM PDE4DIP TTC39A	2.17e-04	175	75	4	1b910c08d2bfbcc77431ee66103e63a11a9d39fe
ToppCell	PCW_13-14-Epithelial-Epithelial_ciliated\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	DNAH3 DNAH9 ODAD3 AK7	2.17e-04	175	75	4	b1369d2b74f461e6822d0c33e9b50fe0dfbceb54
ToppCell	PCW_13-14-Epithelial-Epithelial_ciliated-epi_ciliated_(14)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	DNAH3 DNAH9 ODAD3 AK7	2.17e-04	175	75	4	c82ec6deb6ccdd991a69a62b6d62d5b14c803d7a
ToppCell	droplet-Liver-LIVER_HEP-30m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WDR19 RB1 DNAH17 TNFAIP2	2.21e-04	176	75	4	5e46a09a36b9645b1b1fcb0b64bd0898561af3a9
ToppCell	PBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	RNF213 MACF1 DTX3L PDZD4	2.26e-04	177	75	4	d3e6c768b88b7906f3c7fdd00ba20842212c14b1
ToppCell	PBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	RNF213 MACF1 DTX3L PDZD4	2.26e-04	177	75	4	f8f101c772c043636bedd6b2ec81409b1d2599bf
ToppCell	COVID-19_Mild-Lymphoid_T/NK-NK_activated\|COVID-19_Mild / Disease group, lineage and cell class	RNF213 MACF1 DTX3L PDZD4	2.26e-04	177	75	4	6978a22fef40c8b455342373abe7593f5ede0fa4
ToppCell	PBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	RNF213 MACF1 DTX3L PDZD4	2.26e-04	177	75	4	936ab2b180a052387124f68d0c7f41c0b164e748
ToppCell	PBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	RNF213 MACF1 DTX3L PDZD4	2.26e-04	177	75	4	d5aeda113afaa2425874394610344570c9078478
ToppCell	5'-Adult-Appendix-Epithelial-Tuft-related-Microfold_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TYRO3 NPR1 IL17REL TNFAIP2	2.36e-04	179	75	4	7aa4137f672dadb3be92009cde6e0ea60a15372d
ToppCell	T_cells-ISG-high_CD4+_T_cells\|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis	ASGR2 RNF213 DTX3L DNAH9	2.36e-04	179	75	4	af35ef8a7768cee0c2af0590e5bec35cee6a4714
ToppCell	5'-Adult-Appendix-Mesenchymal-fibroblastic-Stromal_2_(NPY+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	WDR81 CLSTN2 ALK DYRK3	2.36e-04	179	75	4	a1ea8daa0fe8900f5a04b555c77fe8ebdaa3908d
ToppCell	normal_Pleural_Fluid-Myeloid_cells-CD141+_DCs\|Myeloid_cells / Location, Cell class and cell subclass	FNIP2 VAC14 CLSTN2 NPAS2	2.41e-04	180	75	4	a0b35067b6f2dbd8145da8bab760e9f650f045b0
ToppCell	facs-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TYRO3 TMEM45A ASIC3 NPAS2	2.41e-04	180	75	4	39ae8586efd91536e9ac6408d26de7e6d6237c41
ToppCell	368C-Epithelial_cells-Epithelial-F_(Ciliated)-\|368C / Donor, Lineage, Cell class and subclass (all cells)	DNAH3 NWD1 DNAH9 AK7	2.46e-04	181	75	4	5a4574f1bfd0b4ca78da7effda43420857e17296
ToppCell	368C-Epithelial_cells-Epithelial-F_(Ciliated)\|368C / Donor, Lineage, Cell class and subclass (all cells)	DNAH3 NWD1 DNAH9 AK7	2.46e-04	181	75	4	a4e891603645f694687e68e585744ddc1a3c8697
ToppCell	PBMC-Control-cDC_12\|Control / Compartment, Disease Groups and Clusters	TYRO3 KNTC1 NWD1 RBL1	2.52e-04	182	75	4	4774066d0f9986abc3d13a2a3bc99ce4f1327ae0
ToppCell	wk_15-18-Hematologic-Meg-ery-Definitive_erythroblast\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	USP7 WDR81 OSBP2 XPO7	2.52e-04	182	75	4	93841f730ca1a735eaaf5f2ccbe5c45ab0e029d1
ToppCell	Adult-Epithelial-ciliated_cell-D122\|Adult / Lineage, Cell type, age group and donor	DNAH3 NWD1 DNAH9 ODAD3	2.52e-04	182	75	4	7ded554a4b441e6496db673ba206c0d76ccad7d9
ToppCell	Control-Epithelial_cells-Airway_ciliated\|Control / group, cell type (main and fine annotations)	DNAH3 NWD1 DNAH9 AK7	2.52e-04	182	75	4	fb725d10d9ed25dfc6d5bb69cfef78513f7d3e8f
ToppCell	10x5'-lymph-node_spleen-Myeloid_Dendritic-DC1\|lymph-node_spleen / Manually curated celltypes from each tissue	FNIP2 VAC14 CLSTN2 TNFAIP2	2.57e-04	183	75	4	c9e3d91f4c3395a73295b92e25608e0effb5d241
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive\|renal_medulla_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK3 RAPGEF5 MACF1 TNFAIP2	2.62e-04	184	75	4	d2bf0135eb56bb410997dccea39c5ede88a0617f
ToppCell	E18.5-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DNAH3 DNAH9 ODAD3 AK7	2.62e-04	184	75	4	797b6a6d6f6aafae98f75ca8bffe8263f8d3ff9b
ToppCell	Ciliated_cells-A-Myositis-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	DNAH3 NWD1 TMEM45A DNAH9	2.62e-04	184	75	4	07c5a9633ccdcd18771e3230d6198a55c400afa6
ToppCell	E18.5-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated-Ciliated_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DNAH3 DNAH9 ODAD3 AK7	2.62e-04	184	75	4	77d5b60a20b277f589b18f7a131142a7ef2dac17
ToppCell	NS-moderate-d_16-33-Epithelial-Ciliated\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	DNAH3 NWD1 DNAH9 AK7	2.68e-04	185	75	4	5e689c2fb36ce3ac2adc8d15f67107f21cf68868
ToppCell	COVID-19-Epithelial_cells-Airway_ciliated\|COVID-19 / group, cell type (main and fine annotations)	DNAH3 NWD1 DNAH9 AK7	2.68e-04	185	75	4	18a40f0a338aa398d81384b5159fb80ce8a2020c
ToppCell	P28-Epithelial-airway_epithelial_cell-club_cell\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	DNAH3 TTC39A DNAH9 AK7	2.73e-04	186	75	4	a26811481668fa25c48a064a56c198685693ad8d
ToppCell	NS-critical-d_16-33-Epithelial-Ciliated\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	DNAH3 NWD1 DNAH9 AK7	2.73e-04	186	75	4	76033438426d8f9c72cd6691a7baf92104c9f03d
ToppCell	P28-Epithelial-airway_epithelial_cell\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	DNAH3 TTC39A DNAH9 AK7	2.73e-04	186	75	4	df80f101954b8ec6ccdb03e702de22e70b65181f
ToppCell	NS-moderate-d_07-13-Epithelial-Ciliated\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	DNAH3 NWD1 DNAH9 AK7	2.73e-04	186	75	4	85787ff207f109ec7e3c0f729ba9bda739c2fdc9
ToppCell	facs-Lung-EPCAM-3m-Epithelial-Ciliated_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WDR19 DNAH9 ODAD3 AK7	2.79e-04	187	75	4	04dba2ed09ee4180830bdf0191921696697ea234
ToppCell	Fetal_29-31_weeks-Epithelial-ciliated_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	DNAH3 NWD1 DNAH9 AK7	2.79e-04	187	75	4	9e10ed56090d82589bc457788282f664b70ace4b
ToppCell	facs-Lung-EPCAM-3m-Epithelial-ciliated_columnar_cell_of_tracheobronchial_tree\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WDR19 DNAH9 ODAD3 AK7	2.79e-04	187	75	4	805dafe22f835ece4dd091d8030d0a63b52a48dd
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	USP34 RNF213 MACF1 ZBTB11	2.85e-04	188	75	4	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
Drug	retinoic acid; Down 200; 1uM; PC3; HT_HG-U133A	USP34 VAC14 PDE4DIP TTC39A TNFAIP2 USP20 DYRK3	2.96e-06	194	73	7	1211_DN
Disease	cognitive function measurement	WDR19 DOCK3 MST1R KNTC1 USP34 KLHL2 VAC14 RAPGEF5 CLSTN2 SOWAHB EXOC4 NPAS2	1.95e-04	1434	73	12	EFO_0008354
Disease	diabetic maculopathy	USP7 ALK	3.92e-04	12	73	2	EFO_0010133
Disease	Depressive disorder	NPY1R CHAT GRPR ALK NPAS2	7.59e-04	289	73	5	C0011581
Disease	intellectual disability (implicated_via_orthology)	IRS4 RB1 RBL1	8.63e-04	75	73	3	DOID:1059 (implicated_via_orthology)
Disease	sensorineural hearing loss (implicated_via_orthology)	DNAH17 DNAH9	1.00e-03	19	73	2	DOID:10003 (implicated_via_orthology)
Disease	depressive disorder (implicated_via_orthology)	NPY1R CHAT	1.35e-03	22	73	2	DOID:1596 (implicated_via_orthology)
Disease	Sezary Syndrome	RB1 CHD3	2.04e-03	27	73	2	C0036920

Protein segments in the cluster

Peptide	Gene	Start	Entry
FDDLCLLIRDEKLMH	CAPZA3	31	Q96KX2
DLRFVACQMELLHSN	ASGR2	156	P07307
EFLRLLALCHTVMSE	ATP8B4	466	Q8TF62
FHENCMLQEEIALLR	CCDC144CP	631	Q8IYA2
HACEVARMALALLDA	NPR1	941	P16066
VLEEMLHNLDFCDIL	CLSTN2	686	Q9H4D0
TLIMCLHDVSDFLLE	CERS5	241	Q8N5B7
CRNFESLVLLLDAMD	NWD1	426	Q149M9
LTDEECRLIIHLAQM	P4HTM	151	Q9NXG6
LLNDNIFHMSLLACA	RB1	476	P06400
MALHFQSLAELEVLC	RANBP17	1	Q9H2T7
EMPCFCLRHDVDALL	NUDCD1	451	Q96RS6
HAMHADCLQELRRYL	MICA	181	Q29983
DDLELLARCHQHLMQ	NPAS2	291	Q99743
HERLRGLEACAMSLD	IL17REL	36	Q6ZVW7
RLHVMEQLCALSFLQ	KCNV1	121	Q6PIU1
FCLHQEIMRLACADI	OR51B2	176	Q9Y5P1
MLEEELRHLEFKCRN	PDZD4	401	Q76G19
DILILMTAAICHDLD	PDE9A	341	O76083
GHDLMDIFLCDVDIR	ERAL1	416	O75616
DFLLDALELCKHTLM	KNTC1	1146	P50748
DQDDMFPALCEVLRH	NLRP2	766	Q9NX02
ARAGHSLDDMLLDCR	ASIC3	151	Q9UHC3
AMINACRDFLELAEI	OSBP2	366	Q969R2
RHNLIDQDMACAILI	MACF1	1796	Q9UPN3
LAFENDDCHLPLAMI	NPY1R	26	P25929
SFQDMADRCLLVLHL	EXOC4	766	Q96A65
LLRQMCDTHFQHLLD	DOCK3	951	Q8IZD9
QHLISMCEDHDRILL	GNE	166	Q9Y223
MNLVLFEDAVAHICR	DNAH17	2771	Q9UFH2
LAMFCLDATALNHDL	DNAH3	661	Q8TD57
FQHASCQLMREVLLL	DTX3L	441	Q8TDB6
AMALHARFAEAECLA	CHD3	1826	Q12873
LPADFCIMHLEDRLQ	FNIP2	1046	Q9P278
MALNDCFLLNLEVDH	GRPR	1	P30550
MEALVCAFSELHIRE	C16orf90	1	A8MZG2
MEERAQHCLSRLLDN	TMEM30CP	1	A0ZSE6
DLVLFEDAMRHVCHI	DNAH9	2796	Q9NYC9
LALEQIDLIHRMCAS	DPEP3	156	Q9H4B8
RNHVCMAFELLSIDL	DYRK3	281	O43781
HELFLEKMRALCADE	IRS4	321	O14654
DMALEYVACDLHRLE	FBXL16	361	Q8N461
LDSCLDIMIEIFNHE	UTP20	1921	O75691
LCLLLNAENIFHSMA	VAC14	556	Q08AM6
ENHCDFVKLRDMLLC	SEPTIN14	276	Q6ZU15
ADLTALCREAAMHAL	SPATA5L1	406	Q9BVQ7
LLEQDIFHRSLMACC	RBL1	491	P28749
QLLHLRCSDTFINEM	OR7E24	201	Q6IFN5
EMLCHIANREFLASL	ODAD3	521	A5D8V7
VFMTTDDLCQALLRH	RAPGEF5	111	Q92565
AMGNIALAFHLLCER	SETD3	151	Q86TU7
ARFCRLLEENVEHNM	SETX	2231	Q7Z333
LARACLHHMEVEFAI	WDR19	681	Q8NEZ3
MARELSQEALLDFLC	SOWAHB	1	A6NEL2
LAMLDLLHVARDIAC	ALK	1221	Q9UM73
HMAVRDLIRAVFLCD	CHST4	91	Q8NCG5
DNHLLALRELARAMC	CHAT	621	P28329
HNLRLLRADMLDFCK	C12orf4	286	Q9NQ89
ELLAALCRQMEHFLD	RNF213	1671	Q63HN8
GCFREELMEALHLHL	TNFAIP2	511	Q03169
LARHLFMSEVLEICE	ZBTB11	291	O95625
ENMAHCEFPLLRDLL	SEPTIN12	276	Q8IYM1
DFCLNIAKLLMDHER	TEX11	336	Q8IYF3
DTQEFLRCLMDQLHE	USP20	231	Q9Y2K6
HLCFENLMEGIERNL	XPO7	1036	Q9UIA9
AFCDMNDVEVPLHLL	USP34	196	Q70CQ2
VDLCLHDNRMADAII	SEC31A	586	O94979
DLMDHENILFLTICF	TMEM45A	211	Q9NWC5
FMQHDVQELCRVLLD	USP7	291	Q93009
LHEALDQCMTALDLF	TTC39A	21	Q5SRH9
HRDLAARNCMLDESF	MST1R	1206	Q04912
FIHRDLAARNCMLAE	TYRO3	651	Q06418
LFILFRVLRAMDACH	WDR81	261	Q562E7
DAQEFLRCLMDLLHE	USP33	271	Q8TEY7
IRAFADMHACTDLLN	KLHL2	161	O95198
TQDCLDHLLVNLRME	AK7	316	Q96M32
CLQEEMLHLRAEFHQ	PDE4DIP	1001	Q5VU43