Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	chromatin	FOXE1 FOXS1 TAF6L ZBTB5 HOXA10 SMARCE1 FOXD4L4 FOXD4L6 PRKDC FOXQ1 FOXD4L3 BRPF1 FOXD4L5	5.23e-06	1480	43	13	GO:0000785
Domain	TF_fork_head_CS_2	FOXE1 FOXS1 FOXD4L4 FOXD4L6 FOXQ1 FOXD4L3 FOXD4L5	1.03e-11	46	43	7	IPR030456
Domain	TF_fork_head_CS_1	FOXE1 FOXS1 FOXD4L4 FOXD4L6 FOXQ1 FOXD4L3 FOXD4L5	1.21e-11	47	43	7	IPR018122
Domain	FORK_HEAD_3	FOXE1 FOXS1 FOXD4L4 FOXD4L6 FOXQ1 FOXD4L3 FOXD4L5	1.64e-11	49	43	7	PS50039
Domain	FH	FOXE1 FOXS1 FOXD4L4 FOXD4L6 FOXQ1 FOXD4L3 FOXD4L5	1.64e-11	49	43	7	SM00339
Domain	FORK_HEAD_1	FOXE1 FOXS1 FOXD4L4 FOXD4L6 FOXQ1 FOXD4L3 FOXD4L5	1.64e-11	49	43	7	PS00657
Domain	FORK_HEAD_2	FOXE1 FOXS1 FOXD4L4 FOXD4L6 FOXQ1 FOXD4L3 FOXD4L5	1.64e-11	49	43	7	PS00658
Domain	Forkhead	FOXE1 FOXS1 FOXD4L4 FOXD4L6 FOXQ1 FOXD4L3 FOXD4L5	1.64e-11	49	43	7	PF00250
Domain	Fork_head_dom	FOXE1 FOXS1 FOXD4L4 FOXD4L6 FOXQ1 FOXD4L3 FOXD4L5	1.64e-11	49	43	7	IPR001766
Domain	-	FOXE1 FOXS1 FOXD4L4 FOXD4L6 FOXQ1 FOXD4L3 FOXD4L5	6.04e-07	218	43	7	1.10.10.10
Domain	WHTH_DNA-bd_dom	FOXE1 FOXS1 FOXD4L4 FOXD4L6 FOXQ1 FOXD4L3 FOXD4L5	1.22e-06	242	43	7	IPR011991
Domain	GDS_CDC24_CS	ALS2 DNMBP	3.63e-03	39	43	2	IPR001331
Domain	DH_1	ALS2 DNMBP	9.25e-03	63	43	2	PS00741
Domain	DH_2	ALS2 DNMBP	1.13e-02	70	43	2	PS50010
Domain	RhoGEF	ALS2 DNMBP	1.13e-02	70	43	2	PF00621
Domain	DH-domain	ALS2 DNMBP	1.16e-02	71	43	2	IPR000219
Domain	-	ALS2 DNMBP	1.16e-02	71	43	2	1.20.900.10
Pubmed	Developmental competence of the gut endoderm: genetic potentiation by GATA and HNF3/fork head proteins.	FOXS1 FOXD4L4 FOXD4L6 FOXQ1 FOXD4L3 FOXD4L5	1.97e-14	16	43	6	10208738
Pubmed	Six members of the mouse forkhead gene family are developmentally regulated.	FOXS1 FOXD4L4 FOXD4L6 FOXD4L3 FOXD4L5	6.76e-12	15	43	5	7689224
Pubmed	Neural transcription factors bias cleavage stage blastomeres to give rise to neural ectoderm.	FOXD4L4 FOXD4L6 FOXD4L3 FOXD4L5	3.03e-11	6	43	4	27092474
Pubmed	The mouse fkh-2 gene. Implications for notochord, foregut, and midbrain regionalization.	FOXD4L4 FOXD4L6 FOXD4L3 FOXD4L5	1.41e-10	8	43	4	8530406
Pubmed	An amphioxus winged helix/forkhead gene, AmphiFoxD: insights into vertebrate neural crest evolution.	FOXD4L4 FOXD4L6 FOXD4L3 FOXD4L5	2.54e-10	9	43	4	12412011
Pubmed	A genetic study of the suppressors of the Engrailed-1 cerebellar phenotype.	FOXD4L4 FOXD4L6 FOXD4L3 FOXD4L5	1.44e-09	13	43	4	16884697
Pubmed	Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending.	FOXD4L4 FOXD4L6 FOXD4L3 FOXD4L5	1.44e-09	13	43	4	7957066
Pubmed	Strain-specific modifier genes of Cecr2-associated exencephaly in mice: genetic analysis and identification of differentially expressed candidate genes.	FOXD4L4 FOXD4L6 FOXD4L3 FOXD4L5	2.74e-09	15	43	4	22045912
Pubmed	Expression of the winged helix genes fkh-4 and fkh-5 defines domains in the central nervous system.	FOXD4L4 FOXD4L6 FOXD4L3 FOXD4L5	3.65e-09	16	43	4	8861101
Pubmed	Functional equivalency between Otx2 and Otx1 in development of the rostral head.	FOXD4L4 FOXD4L6 FOXD4L3 FOXD4L5	7.74e-09	19	43	4	9895322
Pubmed	Forkhead transcription factor Foxf2 (LUN)-deficient mice exhibit abnormal development of secondary palate.	FOXD4L4 FOXD4L6 FOXD4L3 FOXD4L5	9.67e-09	20	43	4	12812790
Pubmed	Sequential roles for Otx2 in visceral endoderm and neuroectoderm for forebrain and midbrain induction and specification.	FOXD4L4 FOXD4L6 FOXD4L3 FOXD4L5	1.19e-08	21	43	4	9449667
Pubmed	Crucial roles of Foxa2 in mouse anterior-posterior axis polarization via regulation of anterior visceral endoderm-specific genes.	FOXD4L4 FOXD4L6 FOXD4L3 FOXD4L5	1.46e-08	22	43	4	17389379
Pubmed	FOXD4a and FOXD4b, two new winged helix transcription factors, are expressed in human leukemia cell lines.	FOXD4L4 FOXD4L6 FOXD4L5	1.76e-08	5	43	3	12234674
Pubmed	Otx2 is required to respond to signals from anterior neural ridge for forebrain specification.	FOXD4L4 FOXD4L6 FOXD4L3 FOXD4L5	2.11e-08	24	43	4	11820816
Pubmed	A Requirement for Zic2 in the Regulation of Nodal Expression Underlies the Establishment of Left-Sided Identity.	FOXD4L4 FOXD4L6 FOXD4L3 FOXD4L5	2.11e-08	24	43	4	29992973
Pubmed	Ssdp1 regulates head morphogenesis of mouse embryos by activating the Lim1-Ldb1 complex.	FOXD4L4 FOXD4L6 FOXD4L3 FOXD4L5	2.97e-08	26	43	4	15857913
Pubmed	Molecular profiling of synovial joints: use of microarray analysis to identify factors that direct the development of the knee and elbow.	FOXD4L4 FOXD4L6 FOXD4L3 FOXD4L5	4.70e-08	29	43	4	22972626
Pubmed	Genome-scale study of transcription factor expression in the branching mouse lung.	FOXD4L4 FOXD4L6 FOXD4L3 FOXD4L5	1.47e-06	67	43	4	22711520
Pubmed	Postsynaptic TRPV1 triggers cell type-specific long-term depression in the nucleus accumbens.	TRPV1 RIMS1	1.49e-06	2	43	2	21076424
Pubmed	Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.	TAF6L DNHD1 CARD11 RIMS1 RPL6	5.83e-06	208	43	5	33230847
Pubmed	CARMA1 is a novel regulator of T-ALL disease and leukemic cell migration to the CNS.	CARD11 PRKDC	8.94e-06	4	43	2	27698445
Pubmed	Spermidine metabolism regulates leukemia stem and progenitor cell function through KAT7 expression in patient-derived mouse models.	ABCD1 PRKDC	8.94e-06	4	43	2	39321266
Pubmed	Human lymphoma mutations reveal CARD11 as the switch between self-antigen-induced B cell death or proliferation and autoantibody production.	CARD11 PRDM1	8.94e-06	4	43	2	23027925
Pubmed	Double-negative feedback loop between microRNA-422a and forkhead box (FOX)G1/Q1/E1 regulates hepatocellular carcinoma tumor growth and metastasis.	FOXE1 FOXQ1	8.94e-06	4	43	2	25251503
Pubmed	Fasting selectively blocks development of acute lymphoblastic leukemia via leptin-receptor upregulation.	PRKDC PRDM1	8.94e-06	4	43	2	27941793
Pubmed	Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus.	HOXA10 FOXD4L4 FOXD4L6 FOXD4L3 FOXD4L5	1.81e-05	263	43	5	20932939
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	HOXA10 SMARCE1 FOXD4L4 FOXD4L6 FOXD4L3 BRPF1 FOXD4L5	2.42e-05	709	43	7	22988430
Pubmed	Bacteria activate sensory neurons that modulate pain and inflammation.	TRPV1 PRKDC	3.12e-05	7	43	2	23965627
Pubmed	Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives.	SESN3 FOXD4L4 FOXD4L6 FOXD4L3 FOXD4L5	3.73e-05	306	43	5	18973680
Pubmed	Gene content and function of the ancestral chromosome fusion site in human chromosome 2q13-2q14.1 and paralogous regions.	FOXD4L4 FOXD4L3	8.15e-05	11	43	2	12421752
Pubmed	Proteomics of herpes simplex virus replication compartments: association of cellular DNA replication, repair, recombination, and chromatin remodeling proteins with ICP8.	SMARCE1 PRKDC	9.78e-05	12	43	2	15140983
Pubmed	ISG15 Connects Autophagy and IFN-γ-Dependent Control of Toxoplasma gondii Infection in Human Cells.	DARS1 PRKDC RPL6 VPS13C	3.36e-04	268	43	4	33024031
Pubmed	Diverse fates of paralogs following segmental duplication of telomeric genes.	FOXD4L4 FOXD4L3	3.40e-04	22	43	2	15233989
Pubmed	IL-23/IL-17A/TRPV1 axis produces mechanical pain via macrophage-sensory neuron crosstalk in female mice.	TRPV1 PRKDC	3.72e-04	23	43	2	34473953
Pubmed	Activating CCT2 triggers Gli-1 activation during hypoxic condition in colorectal cancer.	DARS1 RPL6	4.40e-04	25	43	2	31462707
Pubmed	VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells.	TAF6L ALS2 RAB3GAP1 RPL6	4.41e-04	288	43	4	23383273
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	METAP1 ZBTB5 DNMBP HECW2 VPS13C	4.77e-04	529	43	5	14621295
Pubmed	Shwachman-Bodian Diamond syndrome is a multi-functional protein implicated in cellular stress responses.	PRKDC RPL6	5.14e-04	27	43	2	19602484
Pubmed	Role of the E3 ubiquitin-ligase Hakai in intestinal inflammation and cancer bowel disease.	PRKDC RPL6	5.14e-04	27	43	2	36266428
Pubmed	A subtractive gene expression screen suggests a role of transcription factor AP-2 alpha in control of proliferation and differentiation.	RPL6 BRPF1	5.14e-04	27	43	2	11741941
Pubmed	Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia.	HOXA10 SMARCE1 PRKDC	5.77e-04	131	43	3	34551306
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	FOXE1 FOXS1 HOXA10 SMARCE1 DARS1 FOXQ1	6.16e-04	857	43	6	25609649
Pubmed	An atlas of combinatorial transcriptional regulation in mouse and man.	FOXS1 ZBTB5 HOXA10 SMARCE1 FOXQ1 BRPF1	6.95e-04	877	43	6	20211142
Pubmed	A census of human transcription factors: function, expression and evolution.	FOXE1 FOXS1 FOXD4L4 FOXQ1 FOXD4L3 PRDM1	8.33e-04	908	43	6	19274049
Pubmed	Protein interaction profiling of the p97 adaptor UBXD1 points to a role for the complex in modulating ERGIC-53 trafficking.	RAB3GAP1 PRKDC	8.66e-04	35	43	2	22337587
Pubmed	A systems wide mass spectrometric based linear motif screen to identify dominant in-vivo interacting proteins for the ubiquitin ligase MDM2.	SMARCE1 RPL6	9.67e-04	37	43	2	24583282
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	MPO ZBTB5 SMARCE1 ALS2	1.04e-03	363	43	4	14691545
Pubmed	LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells.	SMARCE1 ITPKC GIGYF1 PRKDC RPL6	1.11e-03	639	43	5	23443559
Pubmed	Expression profiles and pathway analysis in HEK 293 T cells overexpressing HIV-1 Tat and nucleocapsid using cDNA microarray.	MPO BRPF1	1.13e-03	40	43	2	18051367
Cytoband	9q21.11	FOXD4L4 FOXD4L6 FOXD4L3 FOXD4L5	1.80e-08	30	43	4	9q21.11
Cytoband	2q21.3	DARS1 RAB3GAP1	8.93e-05	15	43	2	2q21.3
Cytoband	Ensembl 112 genes in cytogenetic band chr9q21	FOXD4L4 FOXD4L3 FOXD4L5	8.71e-04	199	43	3	chr9q21
Cytoband	Ensembl 112 genes in cytogenetic band chr17q22	MPO OR4D2	3.12e-03	88	43	2	chr17q22
GeneFamily	Forkhead boxes	FOXE1 FOXS1 FOXQ1	3.52e-05	43	27	3	508
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ALS2 DNMBP	4.34e-03	66	27	2	722
Coexpression	MEISSNER_BRAIN_HCP_WITH_H3K27ME3	FOXE1 HOXA10 FOXD4L4 FOXD4L6 RBMXL3 FOXD4L3 FOXD4L5	3.58e-07	282	43	7	MM822
Coexpression	MEISSNER_NPC_HCP_WITH_H3K4ME2_AND_H3K27ME3	FOXE1 FOXD4L4 FOXD4L6 FOXQ1 FOXD4L3 FOXD4L5 ADGRB1	1.73e-06	357	43	7	MM828
Coexpression	MORI_MATURE_B_LYMPHOCYTE_UP	FOXD4L4 FOXD4L6 FOXD4L3 FOXD4L5	2.76e-05	106	43	4	MM595
Coexpression	MIKKELSEN_NPC_HCP_WITH_H3K4ME3_AND_H3K27ME3	FOXD4L4 FOXD4L6 FOXQ1 FOXD4L3 FOXD4L5	2.77e-05	217	43	5	MM861
Disease	Liver Cirrhosis, Alcoholic	MPO TM6SF2	6.87e-04	30	38	2	C0023891
Disease	Combined immunodeficiency	CARD11 PRKDC	1.28e-03	41	38	2	C0494261
Disease	Diffuse Large B-Cell Lymphoma	CARD11 PRDM1	2.30e-03	55	38	2	C0079744
Disease	fatty acid measurement	NEK4 TAF6L DARS1 TM6SF2	2.33e-03	436	38	4	EFO_0005110

Protein segments in the cluster

Peptide	Gene	Start	Entry
LLPRLYPPLFMLYAL	ALS2	1481	Q96Q42
TLRNPDPRRYTLYMK	ADGRB1	71	O14514
MPPNKPYSFARYRTT	ALKBH8	76	Q96BT7
ARTRDYASLPPKRMY	DNMBP	451	Q6XZF7
LPLPRRMADYLRQYP	CISH	241	Q9NSE2
APSRYFRPYSLMVVP	DNHD1	301	Q96M86
PRPAPYSKALPQRMY	RAB3GAP1	946	Q15042
KDPLRPFVPAYYGMV	ITPKC	446	Q96DU7
LYKPPPQRMFYIPQR	ABCD1	531	P33897
LPPYPSFSMLYEKLL	HECW2	1546	Q9P2P5
YLYARPFTPFPMDKL	OR4D2	256	P58180
YRYTGKLRPHYPLMP	METAP1	81	P53582
PPSPAMPKYKLADYR	GIGYF1	26	O75420
PAKPPYSYIALITMA	FOXD4L4	106	Q8WXT5
PAKPPYSYIALITMA	FOXD4L3	106	Q6VB84
VLGPTAMRKYLPTYR	MPO	466	P05164
YRIIEGKLPPMPRDY	NEK4	216	P51957
MSARKGYLLPSPNYP	HOXA10	1	P31260
RPRNPYVKMYFLPDR	RIMS1	776	Q86UR5
PTKPPYSYIALIAMA	FOXS1	16	O43638
DSKYFLPYHPPQRRM	CARD11	486	Q9BXL7
RRPKPPYSYIALIAM	FOXQ1	116	Q9C009
YRRPAKLSAPRYMAL	MOB3C	106	Q70IA8
SPAPRALMAPYYKRL	MMP28	251	Q9H239
YGPSPASRYVQKLPM	TAF6L	586	Q9Y6J9
RKPPAIPIRYYAIMV	SLC35B4	56	Q969S0
PDKPLMPYMRYSRKV	SMARCE1	66	Q969G3
RGKPPYSYIALIAMA	FOXE1	51	O00358
KPFYPALIRYMSSGP	NME4	91	O00746
PAKPPYSYIALITMA	FOXD4L5	106	Q5VV16
PAKPPYSYIALITMA	FOXD4L6	106	Q3SYB3
MPFYPRVVYPIRAPL	PRDM1	291	O75626
LDKYPLAVRPFYTMP	DARS1	391	P14868
RMIPYPLEKGHLFYP	ST7	471	Q9NRC1
YPSYPALIIDPKMPR	BRPF1	1096	P55201
NFPYYRRIAPKMPVV	ZBTB5	531	O15062
YFDLWPYRAPMPRKR	RBMXL3	136	Q8N7X1
KMPRYYPTEDVPRKL	RPL6	111	Q02878
MAAYYRPVDGLPPFK	TRPV1	451	Q8NER1
MLRMDGPLPLPYRHY	SESN3	96	P58005
MVRNAPYRKYKPYLP	VPS13C	351	Q709C8
PPMYQLYKRTFPVLL	PRKDC	956	P78527
PYLRDPVAYPKVQML	TM6SF2	256	Q9BZW4