Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	G protein-coupled UTP receptor activity	P2RY2 P2RY4	3.47e-06	3	22	2	GO:0045030
GeneOntologyMolecularFunction	sucrose transmembrane transporter activity	SLC45A3 SLC45A2	6.94e-06	4	22	2	GO:0008515
GeneOntologyMolecularFunction	sucrose:proton symporter activity	SLC45A3 SLC45A2	6.94e-06	4	22	2	GO:0008506
GeneOntologyMolecularFunction	oligosaccharide transmembrane transporter activity	SLC45A3 SLC45A2	6.94e-06	4	22	2	GO:0015157
GeneOntologyMolecularFunction	disaccharide transmembrane transporter activity	SLC45A3 SLC45A2	6.94e-06	4	22	2	GO:0015154
GeneOntologyMolecularFunction	sucrose:monoatomic cation symporter activity	SLC45A3 SLC45A2	6.94e-06	4	22	2	GO:0009669
GeneOntologyMolecularFunction	G protein-coupled pyrimidinergic nucleotide receptor activity	P2RY2 P2RY4	6.94e-06	4	22	2	GO:0071553
GeneOntologyMolecularFunction	carbohydrate:proton symporter activity	SLC45A3 SLC45A2	3.23e-05	8	22	2	GO:0005351
GeneOntologyMolecularFunction	G protein-coupled purinergic nucleotide receptor activity	P2RY2 P2RY4	8.97e-05	13	22	2	GO:0045028
GeneOntologyMolecularFunction	carbohydrate:monoatomic cation symporter activity	SLC45A3 SLC45A2	1.56e-04	17	22	2	GO:0005402
GeneOntologyMolecularFunction	nucleotide receptor activity	P2RY2 P2RY4	2.64e-04	22	22	2	GO:0016502
GeneOntologyMolecularFunction	purinergic nucleotide receptor activity	P2RY2 P2RY4	2.64e-04	22	22	2	GO:0001614
GeneOntologyMolecularFunction	solute:proton symporter activity	SLC45A3 SLC45A2	3.42e-04	25	22	2	GO:0015295
GeneOntologyMolecularFunction	sugar transmembrane transporter activity	SLC45A3 SLC45A2	4.62e-04	29	22	2	GO:0051119
GeneOntologyMolecularFunction	carbohydrate transmembrane transporter activity	SLC45A3 SLC45A2	9.71e-04	42	22	2	GO:0015144
GeneOntologyMolecularFunction	solute:monoatomic cation symporter activity	SLC45A3 SLC45A2	7.53e-03	119	22	2	GO:0015294
GeneOntologyMolecularFunction	symporter activity	SLC45A3 SLC45A2	1.17e-02	150	22	2	GO:0015293
GeneOntologyBiologicalProcess	oligosaccharide transport	SLC45A3 SLC45A2	5.92e-06	4	21	2	GO:0015772
GeneOntologyBiologicalProcess	sucrose transport	SLC45A3 SLC45A2	5.92e-06	4	21	2	GO:0015770
GeneOntologyBiologicalProcess	disaccharide transport	SLC45A3 SLC45A2	5.92e-06	4	21	2	GO:0015766
GeneOntologyBiologicalProcess	G protein-coupled purinergic nucleotide receptor signaling pathway	P2RY2 P2RY4	7.65e-05	13	21	2	GO:0035589
GeneOntologyBiologicalProcess	chondroitin sulfate biosynthetic process	CHST7 B3GALT6	1.86e-04	20	21	2	GO:0030206
GeneOntologyBiologicalProcess	cellular response to ATP	P2RY2 P2RY4	2.05e-04	21	21	2	GO:0071318
GeneOntologyBiologicalProcess	chondroitin sulfate proteoglycan biosynthetic process	CHST7 B3GALT6	3.16e-04	26	21	2	GO:0050650
GeneOntologyBiologicalProcess	regulation of presynaptic cytosolic calcium ion concentration	P2RY2 P2RY4	3.16e-04	26	21	2	GO:0099509
GeneOntologyBiologicalProcess	chondroitin sulfate metabolic process	CHST7 B3GALT6	3.94e-04	29	21	2	GO:0030204
GeneOntologyBiologicalProcess	purinergic nucleotide receptor signaling pathway	P2RY2 P2RY4	5.11e-04	33	21	2	GO:0035590
GeneOntologyBiologicalProcess	chondroitin sulfate proteoglycan metabolic process	CHST7 B3GALT6	5.76e-04	35	21	2	GO:0050654
Domain	MFS	SLC45A3 SLC45A2	3.35e-03	77	21	2	IPR011701
Domain	MFS_1	SLC45A3 SLC45A2	3.35e-03	77	21	2	PF07690
Domain	IQ	XKR7 IQCN	3.70e-03	81	21	2	SM00015
Domain	IQ_motif_EF-hand-BS	XKR7 IQCN	4.54e-03	90	21	2	IPR000048
Domain	MFS_dom	SLC45A3 SLC45A2	9.81e-03	134	21	2	IPR020846
Domain	P-loop_NTPase	HELZ2 CHST7 SEPTIN4 IQCN	1.36e-02	848	21	4	IPR027417
Pathway	REACTOME_P2Y_RECEPTORS	P2RY2 P2RY4	3.03e-05	11	11	2	MM15049
Pathway	WP_NUCLEOTIDE_GPCRS	P2RY2 P2RY4	3.03e-05	11	11	2	M39422
Pathway	REACTOME_P2Y_RECEPTORS	P2RY2 P2RY4	3.64e-05	12	11	2	M10960
Pathway	WP_NUCLEOTIDE_GPCRS	P2RY2 P2RY4	3.64e-05	12	11	2	MM15953
Pathway	REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS	P2RY2 P2RY4	6.60e-05	16	11	2	M6786
Pathway	REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS	P2RY2 P2RY4	6.60e-05	16	11	2	MM15050
Pathway	KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE	CHST7 B3GALT6	1.27e-04	22	11	2	M19166
Pathway	WP_PURINERGIC_SIGNALING	P2RY2 P2RY4	2.88e-04	33	11	2	M39855
Pathway	WP_GLYCOSAMINOGLYCAN_SYNTHESIS_IN_FIBROBLASTS	CHST7 B3GALT6	4.46e-04	41	11	2	M48095
Pathway	REACTOME_ACTIVATION_OF_GENE_EXPRESSION_BY_SREBF_SREBP	HELZ2 FASN	4.69e-04	42	11	2	M27172
Pathway	REACTOME_CHONDROITIN_SULFATE_DERMATAN_SULFATE_METABOLISM	CHST7 B3GALT6	6.12e-04	48	11	2	MM14696
Pathway	REACTOME_CHONDROITIN_SULFATE_DERMATAN_SULFATE_METABOLISM	CHST7 B3GALT6	6.64e-04	50	11	2	M678
Pathway	REACTOME_REGULATION_OF_CHOLESTEROL_BIOSYNTHESIS_BY_SREBP_SREBF	HELZ2 FASN	8.04e-04	55	11	2	M27001
Pathway	WP_GPCRS_CLASS_A_RHODOPSINLIKE	GHSR P2RY2 P2RY4	9.17e-04	260	11	3	M39397
Pathway	WP_GPCRS_NONODORANT	GHSR P2RY2 P2RY4	9.80e-04	266	11	3	MM15843
Pathway	KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	GHSR P2RY2 P2RY4	1.05e-03	272	11	3	M13380
Pathway	REACTOME_CLASS_A_1_RHODOPSIN_LIKE_RECEPTORS	GHSR P2RY2 P2RY4	1.82e-03	330	11	3	M18334
Pathway	REACTOME_GLYCOSAMINOGLYCAN_METABOLISM	CHST7 B3GALT6	3.94e-03	123	11	2	MM14623
Pathway	REACTOME_GLYCOSAMINOGLYCAN_METABOLISM	CHST7 B3GALT6	4.14e-03	126	11	2	M695
Pathway	REACTOME_GPCR_LIGAND_BINDING	GHSR P2RY2 P2RY4	4.77e-03	463	11	3	M507
Pathway	WP_METAPATHWAY_BIOTRANSFORMATION	CHST7 CYP2U1	6.04e-03	153	11	2	MM15844
Pathway	REACTOME_METABOLISM_OF_STEROIDS	HELZ2 FASN	6.11e-03	154	11	2	M27832
Pathway	REACTOME_FATTY_ACID_METABOLISM	CYP2U1 FASN	7.40e-03	170	11	2	MM15573
Pathway	REACTOME_FATTY_ACID_METABOLISM	CYP2U1 FASN	7.92e-03	176	11	2	M27854
Pathway	WP_METAPATHWAY_BIOTRANSFORMATION_PHASE_I_AND_II	CHST7 CYP2U1	8.53e-03	183	11	2	M39588
Pathway	WP_GPCRS_CLASS_A_RHODOPSINLIKE	P2RY2 P2RY4	8.81e-03	186	11	2	MM15994
Pathway	REACTOME_METABOLISM_OF_LIPIDS	HELZ2 CYP2U1 FASN	1.07e-02	620	11	3	MM15193
Pathway	REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS	GHSR P2RY2	1.11e-02	210	11	2	MM15043
Pathway	REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS	GHSR P2RY2	1.18e-02	217	11	2	M18437
Pathway	REACTOME_SIGNALING_BY_GPCR	GHSR P2RY2 P2RY4	1.20e-02	646	11	3	MM14962
Pathway	REACTOME_SIGNALING_BY_GPCR	GHSR P2RY2 P2RY4	1.50e-02	702	11	3	M746
Pathway	REACTOME_DISEASES_OF_METABOLISM	B3GALT6 CYP2U1	1.55e-02	250	11	2	M27554
Pathway	REACTOME_METABOLISM_OF_CARBOHYDRATES	CHST7 B3GALT6	1.81e-02	271	11	2	MM15406
Pathway	REACTOME_METABOLISM_OF_LIPIDS	HELZ2 CYP2U1 FASN	1.84e-02	757	11	3	M27451
Pathway	REACTOME_METABOLISM_OF_CARBOHYDRATES	CHST7 B3GALT6	2.03e-02	288	11	2	M16864
Pubmed	Distribution of P2Y receptor subtypes on haematopoietic cells.	P2RY2 P2RY4	4.18e-07	2	23	2	9535005
Pubmed	K+ secretion activated by luminal P2Y2 and P2Y4 receptors in mouse colon.	P2RY2 P2RY4	4.18e-07	2	23	2	15718265
Pubmed	ATP modulates transcription factors through P2Y2 and P2Y4 receptors via PKC/MAPKs and PKC/Src pathways in MCF-7 cells.	P2RY2 P2RY4	4.18e-07	2	23	2	19900397
Pubmed	Extracellular ATP activates MAP kinase cascades through a P2Y purinergic receptor in the human intestinal Caco-2 cell line.	P2RY2 P2RY4	4.18e-07	2	23	2	19836435
Pubmed	Autocrine and paracrine roles for ATP and serotonin in mouse taste buds.	P2RY2 P2RY4	1.25e-06	3	23	2	19890001
Pubmed	Human keratinocytes express multiple P2Y-receptors: evidence for functional P2Y1, P2Y2, and P2Y4 receptors.	P2RY2 P2RY4	1.25e-06	3	23	2	12603858
Pubmed	Cloning and functional characterization of two murine uridine nucleotide receptors reveal a potential target for correcting ion transport deficiency in cystic fibrosis gallbladder.	P2RY2 P2RY4	1.25e-06	3	23	2	11259526
Pubmed	Functional expression and intracellular signaling of UTP-sensitive P2Y receptors in theca-interstitial cells.	P2RY2 P2RY4	1.25e-06	3	23	2	20630102
Pubmed	Loss of nucleotide regulation of epithelial chloride transport in the jejunum of P2Y4-null mice.	P2RY2 P2RY4	1.25e-06	3	23	2	12644577
Pubmed	Proton-associated sucrose transport of mammalian solute carrier family 45: an analysis in Saccharomyces cerevisiae.	SLC45A3 SLC45A2	1.25e-06	3	23	2	25164149
Pubmed	Purinergic receptors on microglial cells: functional expression in acute brain slices and modulation of microglial activation in vitro.	P2RY2 P2RY4	2.51e-06	4	23	2	12814360
Pubmed	Nucleotides downregulate aquaporin 2 via activation of apical P2 receptors.	P2RY2 P2RY4	2.51e-06	4	23	2	19423692
Pubmed	Knock-out mice reveal the contributions of P2Y and P2X receptors to nucleotide-induced Ca2+ signaling in macrophages.	P2RY2 P2RY4	2.51e-06	4	23	2	16980298
Pubmed	P2Y and P2X purinoceptor mediated Ca2+ signalling in glial cell pathology in the central nervous system.	P2RY2 P2RY4	2.51e-06	4	23	2	12151016
Pubmed	Expression pattern of human P2Y receptor subtypes: a quantitative reverse transcription-polymerase chain reaction study.	P2RY2 P2RY4	4.18e-06	5	23	2	11690642
Pubmed	Multiple P2X and P2Y receptor subtypes in mouse J774, spleen and peritoneal macrophages.	P2RY2 P2RY4	6.26e-06	6	23	2	15670583
Pubmed	Expression of astrocyte-related receptors in cortical dysplasia with intractable epilepsy.	P2RY2 P2RY4	8.77e-06	7	23	2	25003238
Pubmed	Expression of P2Y(6) receptors in the developing mouse skeletal muscle and after injury and repair.	P2RY2 P2RY4	8.77e-06	7	23	2	21413988
Pubmed	The DNA sequence of the human X chromosome.	XAGE3 CHST7 P2RY4 MAP3K15	1.37e-04	407	23	4	15772651
Interaction	FMO4 interactions	CYP2U1 XKR7	2.16e-05	7	21	2	int:FMO4
Cytoband	Ensembl 112 genes in cytogenetic band chr19p13	MISP TIMM29 IQCN PEAK3	6.14e-04	797	23	4	chr19p13
Cytoband	19p13.3	MISP PEAK3	6.25e-03	237	23	2	19p13.3
Cytoband	Ensembl 112 genes in cytogenetic band chr20q11	FER1L4 XKR7	6.82e-03	248	23	2	chr20q11
GeneFamily	Purinergic receptors P2Y	P2RY2 P2RY4	2.88e-05	10	15	2	213
GeneFamily	Solute carriers	SLC45A3 SLC45A2	4.14e-02	395	15	2	752
Drug	N-butyrylhomoserine lactone	P2RY2 P2RY4	9.76e-07	2	23	2	ctd:C092312
Drug	N-(3-oxododecanoyl)homoserine lactone	P2RY2 P2RY4	9.74e-06	5	23	2	ctd:C109860
Drug	xanthine amine congener	GHSR P2RY2 P2RY4	3.60e-05	64	23	3	CID000005697
Drug	A3P5PS	P2RY2 P2RY4	8.82e-05	14	23	2	CID005310943
Drug	5BrUTP	P2RY2 P2RY4	1.02e-04	15	23	2	CID000122301
Drug	Uridine Triphosphate	P2RY2 P2RY4	1.16e-04	16	23	2	ctd:D014544
Drug	adenosine 3'-5'-diphosphate	CHST7 P2RY2 P2RY4	1.29e-04	98	23	3	CID000000073
Drug	pleuromutilin	PDF FASN	1.48e-04	18	23	2	CID000031326
Drug	AC1L1F6H	P2RY2 P2RY4 SLC45A2	1.62e-04	106	23	3	CID000003104
Drug	bH-L	P2RY2 P2RY4	1.83e-04	20	23	2	CID000077970
Drug	P2-N	P2RY2 SLC45A2	2.89e-04	25	23	2	CID011987828
Drug	AC1L1IZE	P2RY2 P2RY4 SLC45A2	3.03e-04	131	23	3	CID000004799
Drug	acetophenone	P2RY4 SLC45A2	4.75e-04	32	23	2	CID000007410
Drug	Mcat	SEPTIN4 FASN	5.69e-04	35	23	2	CID003080785
Drug	Ap6A	P2RY2 P2RY4	6.02e-04	36	23	2	CID000123694
Drug	triclosan	PDF FASN	6.71e-04	38	23	2	CID000005564
Drug	sterigmatocystin	SLC45A2 FASN	7.07e-04	39	23	2	CID005280389
Drug	N-acetylmethionine	SLC45A2 PDF	7.07e-04	39	23	2	CID000006180
Drug	nifedipine	P2RY2 SEPTIN4 CYP2U1 SLC45A2	7.32e-04	415	23	4	CID000004485
Drug	m189	P2RY2 P2RY4 PDF	7.42e-04	178	23	3	CID000022230
Drug	octanoate	GHSR SLC45A2 FASN	7.78e-04	181	23	3	CID000000379
Drug	bromouridine	P2RY2 P2RY4	8.60e-04	43	23	2	CID000091494
Drug	Adenosine Triphosphate	P2RY2 P2RY4 FASN	9.37e-04	193	23	3	ctd:D000255
Drug	Fosfosal [6064-83-1]; Up 200; 18.4uM; HL60; HT_HG-U133A	CHST7 P2RY4 SLC45A2	1.04e-03	200	23	3	2997_UP
Drug	AhR antagonist	CYP2U1 SLC45A2	1.26e-03	52	23	2	CID003091786
Drug	AC1N1QTU	P2RY2 P2RY4	1.30e-03	53	23	2	CID003985498
Disease	cutaneous melanoma, hair color	SLC45A2 DOCK8-AS1	7.26e-04	62	19	2	EFO_0000389, EFO_0003924
Disease	cutaneous melanoma	SLC45A2 DOCK8-AS1	2.72e-03	121	19	2	EFO_0000389
Disease	basophil count	HELZ2 P2RY2 SLC45A3	3.47e-03	483	19	3	EFO_0005090
Disease	skin aging measurement	SLC45A2 DOCK8-AS1	5.97e-03	181	19	2	EFO_0008006
Disease	Adenocarcinoma of lung (disorder)	FASN MAP3K15	7.67e-03	206	19	2	C0152013
Disease	testosterone measurement	GHSR P2RY2 FASN IQCN	7.99e-03	1275	19	4	EFO_0004908
Disease	melanoma	SLC45A2 FASN	1.09e-02	248	19	2	C0025202
Disease	eosinophil count	HELZ2 SLC45A3 TIMM29 STOX1	1.36e-02	1488	19	4	EFO_0004842
Disease	ankylosing spondylitis, psoriasis, ulcerative colitis, Crohn's disease, sclerosing cholangitis	B3GALT6 FASN	1.52e-02	295	19	2	EFO_0000384, EFO_0000676, EFO_0000729, EFO_0003898, EFO_0004268

Protein segments in the cluster

Peptide	Gene	Start	Entry
RAREPARRRRLYWGF	B3GALT6	171	Q96L58
GVRGYLARRRIRLWH	IQCN	936	Q9H0B3
RGVVRWEYFRLRPLR	MISP	496	Q8IVT2
RPWARLRVRLYRAEG	FER1L4	186	A9Z1Z3
GPWLRVRRGLLVLRL	PEAK3	421	Q6ZS72
GPALRRSYWRHLRRL	PDF	41	Q9HBH1
LRPLRSLRWGRARYA	P2RY2	136	P41231
LRALRWGRPRLAGLL	P2RY4	141	P51582
LGWSWLRRRRARGIP	CYP2U1	46	Q7Z449
RYWGRRRALPGAADL	DOCK8-AS1	231	Q5T8R8
LYSLIGRKLWRRRRG	GHSR	231	Q92847
AGRPGLRLLWRRRVY	HELZ2	1786	Q9BYK8
DDRRWKAGLYGLPRR	FASN	36	P49327
RSRWGRRRPYILTLG	SLC45A2	96	Q9UMX9
RYLRLRGGLLCRLWS	MAP3K15	1281	Q6ZN16
RGRRVRGRLYPWGIV	SEPTIN4	356	O43236
QRLLWLRGRGRLRYV	TIMM29	111	Q9BSF4
RYGRRRPFIWALSLG	SLC45A3	81	Q96JT2
LLFARGAPAWLRRRY	CHST7	356	Q9NS84
GAPAWLRRRYLRLRY	CHST7	361	Q9NS84
YLGLQSRWRGERLRR	XKR7	201	Q5GH72
AWRRRALRPPRGFRI	STOX1	86	Q6ZVD7
RWKPFLYRGRICRRL	TMEM168	251	Q9H0V1
MIWRGRSTYRPRPRR	XAGE3	1	Q8WTP9