Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionactive transmembrane transporter activity

SLC6A1 ABCC1 SLC6A12 SLC6A13 ABCA1 ATP8A1 SLCO4C1 SLC24A4 SLC26A7 SLC6A5 SLC38A7 ATP1A2 ATP1A4

1.91e-104775213GO:0022804
GeneOntologyMolecularFunctiontransporter activity

SLC6A1 ABCC1 SLC6A12 SLC6A13 ABCA1 GJB5 ATP8A1 SLCO4C1 SLC24A4 SLC26A7 ATP8A2 GSDMD SLC6A5 SLC38A7 DISP2 HTR3B ATP1A2 ATP1A4

1.75e-0912895218GO:0005215
GeneOntologyMolecularFunctionamino acid:sodium symporter activity

SLC6A1 SLC6A12 SLC6A13 SLC6A5 SLC38A7

3.19e-0923525GO:0005283
GeneOntologyMolecularFunctiontransmembrane transporter activity

SLC6A1 ABCC1 SLC6A12 SLC6A13 ABCA1 GJB5 ATP8A1 SLCO4C1 SLC24A4 SLC26A7 GSDMD SLC6A5 SLC38A7 DISP2 HTR3B ATP1A2 ATP1A4

3.56e-0911805217GO:0022857
GeneOntologyMolecularFunctionactive monoatomic ion transmembrane transporter activity

SLC6A1 SLC6A12 SLC6A13 ATP8A1 SLC24A4 SLC26A7 SLC6A5 SLC38A7 ATP1A2 ATP1A4

4.72e-093015210GO:0022853
GeneOntologyMolecularFunctionamino acid:monoatomic cation symporter activity

SLC6A1 SLC6A12 SLC6A13 SLC6A5 SLC38A7

1.11e-0829525GO:0005416
GeneOntologyMolecularFunctionsodium ion transmembrane transporter activity

SLC6A1 SLC6A12 SLC6A13 SLC24A4 SLC6A5 SLC38A7 ATP1A2 ATP1A4

1.34e-08171528GO:0015081
GeneOntologyMolecularFunctionorganic acid:sodium symporter activity

SLC6A1 SLC6A12 SLC6A13 SLC6A5 SLC38A7

3.01e-0835525GO:0005343
GeneOntologyMolecularFunctiongamma-aminobutyric acid:sodium:chloride symporter activity

SLC6A1 SLC6A12 SLC6A13

3.31e-076523GO:0005332
GeneOntologyMolecularFunctionorganic anion transmembrane transporter activity

SLC6A1 ABCC1 SLC6A12 SLC6A13 SLCO4C1 SLC26A7 SLC6A5 SLC38A7

8.40e-07293528GO:0008514
GeneOntologyMolecularFunctionsecondary active transmembrane transporter activity

SLC6A1 SLC6A12 SLC6A13 SLCO4C1 SLC24A4 SLC26A7 SLC6A5 SLC38A7

9.06e-07296528GO:0015291
GeneOntologyMolecularFunctioncarboxylic acid transmembrane transporter activity

SLC6A1 ABCC1 SLC6A12 SLC6A13 SLC26A7 SLC6A5 SLC38A7

1.05e-06207527GO:0046943
GeneOntologyMolecularFunctionorganic acid transmembrane transporter activity

SLC6A1 ABCC1 SLC6A12 SLC6A13 SLC26A7 SLC6A5 SLC38A7

1.08e-06208527GO:0005342
GeneOntologyMolecularFunctionphosphatidylserine floppase activity

ABCA1 ATP8A1 ATP8A2

1.38e-069523GO:0090556
GeneOntologyMolecularFunctiongamma-aminobutyric acid transmembrane transporter activity

SLC6A1 SLC6A12 SLC6A13

1.38e-069523GO:0015185
GeneOntologyMolecularFunctionsolute:sodium symporter activity

SLC6A1 SLC6A12 SLC6A13 SLC6A5 SLC38A7

2.17e-0681525GO:0015370
GeneOntologyMolecularFunctionsymporter activity

SLC6A1 SLC6A12 SLC6A13 SLC24A4 SLC6A5 SLC38A7

2.49e-06150526GO:0015293
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

SLC6A1 SLC6A12 SLC6A13 ATP8A1 SLC24A4 SLC26A7 SLC6A5 SLC38A7 HTR3B ATP1A2 ATP1A4

4.92e-067935211GO:0015075
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

SLC6A1 SLC6A12 SLC6A13 ATP8A1 SLC24A4 SLC6A5 SLC38A7 HTR3B ATP1A2 ATP1A4

6.92e-066645210GO:0008324
GeneOntologyMolecularFunctionmonocarboxylate:sodium symporter activity

SLC6A1 SLC6A12 SLC6A13

7.41e-0615523GO:0140161
GeneOntologyMolecularFunctionamino acid transmembrane transporter activity

SLC6A1 SLC6A12 SLC6A13 SLC6A5 SLC38A7

7.80e-06105525GO:0015171
GeneOntologyMolecularFunctionfloppase activity

ABCA1 ATP8A1 ATP8A2

9.11e-0616523GO:0140328
GeneOntologyMolecularFunctionATPase-coupled transmembrane transporter activity

ABCC1 ABCA1 ATP8A1 ATP1A2 ATP1A4

9.36e-06109525GO:0042626
GeneOntologyMolecularFunctionsodium:chloride symporter activity

SLC6A1 SLC6A12 SLC6A13

1.10e-0517523GO:0015378
GeneOntologyMolecularFunctionsolute:monoatomic cation symporter activity

SLC6A1 SLC6A12 SLC6A13 SLC6A5 SLC38A7

1.44e-05119525GO:0015294
GeneOntologyMolecularFunctionsecondary active monocarboxylate transmembrane transporter activity

SLC6A1 SLC6A12 SLC6A13

1.57e-0519523GO:0015355
GeneOntologyMolecularFunctionmonoatomic anion:sodium symporter activity

SLC6A1 SLC6A12 SLC6A13

1.57e-0519523GO:0015373
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

SLC6A1 ABCC1 SLC6A12 SLC6A13 SLC24A4 SLC26A7 SLC6A5 SLC38A7 ATP1A2 ATP1A4

2.18e-057585210GO:0015318
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

SLC6A1 SLC6A12 SLC6A13 SLC24A4 SLC6A5 SLC38A7 ATP1A2 ATP1A4

2.49e-05465528GO:0046873
GeneOntologyMolecularFunctionchloride:monoatomic cation symporter activity

SLC6A1 SLC6A12 SLC6A13

2.84e-0523523GO:0015377
GeneOntologyMolecularFunctionmonoatomic anion:monoatomic cation symporter activity

SLC6A1 SLC6A12 SLC6A13

4.15e-0526523GO:0015296
GeneOntologyMolecularFunctionATPase-coupled intramembrane lipid transporter activity

ABCA1 ATP8A1 ATP8A2

5.21e-0528523GO:0140326
GeneOntologyMolecularFunctionphosphatidylserine flippase activity

ATP8A1 ATP8A2

6.62e-055522GO:0140346
GeneOntologyMolecularFunctioninorganic anion transmembrane transporter activity

SLC6A1 ABCC1 SLC6A12 SLC6A13 SLC26A7

8.15e-05171525GO:0015103
GeneOntologyMolecularFunctionmonocarboxylic acid transmembrane transporter activity

SLC6A1 ABCC1 SLC6A12 SLC6A13

8.85e-0590524GO:0008028
GeneOntologyMolecularFunctionprimary active transmembrane transporter activity

ABCC1 ABCA1 ATP8A1 ATP1A2 ATP1A4

9.85e-05178525GO:0015399
GeneOntologyMolecularFunctionaminophospholipid flippase activity

ATP8A1 ATP8A2

1.39e-047522GO:0015247
GeneOntologyMolecularFunctionneutral L-amino acid:sodium symporter activity

SLC6A5 SLC38A7

1.84e-048522GO:0005295
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

SLC6A1 SLC6A12 SLC6A13 SLC24A4 SLC6A5 SLC38A7 ATP1A2 ATP1A4

2.01e-04627528GO:0022890
GeneOntologyMolecularFunctionP-type sodium transporter activity

ATP1A2 ATP1A4

2.95e-0410522GO:0008554
GeneOntologyMolecularFunctionP-type sodium:potassium-exchanging transporter activity

ATP1A2 ATP1A4

2.95e-0410522GO:0005391
GeneOntologyMolecularFunctionchloride transmembrane transporter activity

SLC6A1 SLC6A12 SLC6A13 SLC26A7

3.14e-04125524GO:0015108
GeneOntologyMolecularFunctionintramembrane lipid transporter activity

ABCA1 ATP8A1 ATP8A2

3.18e-0451523GO:0140303
GeneOntologyMolecularFunctionP-type potassium transmembrane transporter activity

ATP1A2 ATP1A4

3.60e-0411522GO:0008556
GeneOntologyMolecularFunctioncytidine deaminase activity

APOBEC3B APOBEC3F

5.09e-0413522GO:0004126
GeneOntologyMolecularFunctionsulfur compound transmembrane transporter activity

ABCC1 SLC6A13 SLC26A7

5.39e-0461523GO:1901682
GeneOntologyMolecularFunctionATPase-coupled monoatomic cation transmembrane transporter activity

ATP8A1 ATP1A2 ATP1A4

5.65e-0462523GO:0019829
GeneOntologyMolecularFunctionglycerophospholipid flippase activity

ATP8A1 ATP8A2

5.93e-0414522GO:0140333
GeneOntologyMolecularFunctionmonoatomic anion transmembrane transporter activity

SLC6A1 SLC6A12 SLC6A13 SLC26A7

6.42e-04151524GO:0008509
GeneOntologyMolecularFunctionG protein-coupled photoreceptor activity

RRH GPR52

6.83e-0415522GO:0008020
GeneOntologyMolecularFunctionphotoreceptor activity

RRH GPR52

8.82e-0417522GO:0009881
GeneOntologyMolecularFunctionflippase activity

ATP8A1 ATP8A2

8.82e-0417522GO:0140327
GeneOntologyMolecularFunctionphospholipid transporter activity

ABCA1 ATP8A1 ATP8A2

9.48e-0474523GO:0005548
GeneOntologyMolecularFunctionATP hydrolysis activity

ABCC1 ABCA1 ATP8A1 ATP8A2 ATP1A2 ATP1A4

9.67e-04441526GO:0016887
GeneOntologyMolecularFunctionprenyltransferase activity

COQ2 RABGGTB

9.91e-0418522GO:0004659
GeneOntologyMolecularFunctionATP-dependent activity

MYD88 ABCC1 ABCA1 ATP8A1 ATP8A2 ATP1A2 ATP1A4

1.01e-03614527GO:0140657
GeneOntologyMolecularFunctionsphingolipid transporter activity

ABCC1 ABCA1

1.23e-0320522GO:0046624
GeneOntologyMolecularFunctionlipid transporter activity

ABCC1 ABCA1 ATP8A1 ATP8A2

1.69e-03196524GO:0005319
GeneOntologyMolecularFunctionmodified amino acid transmembrane transporter activity

ABCC1 SLC6A13

3.34e-0333522GO:0072349
GeneOntologyMolecularFunctiondeaminase activity

APOBEC3B APOBEC3F

3.54e-0334522GO:0019239
GeneOntologyMolecularFunctionP-type transmembrane transporter activity

ATP1A2 ATP1A4

3.96e-0336522GO:0140358
GeneOntologyMolecularFunctionP-type ion transporter activity

ATP1A2 ATP1A4

3.96e-0336522GO:0015662
GeneOntologyMolecularFunctionhydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines

APOBEC3B APOBEC3F

3.96e-0336522GO:0016814
GeneOntologyMolecularFunctionwide pore channel activity

GJB5 GSDMD

4.18e-0337522GO:0022829
GeneOntologyMolecularFunctionsteroid binding

ABCA1 ATP1A2 SERPINA6

5.03e-03133523GO:0005496
GeneOntologyMolecularFunctionneutral L-amino acid transmembrane transporter activity

SLC6A5 SLC38A7

5.11e-0341522GO:0015175
GeneOntologyMolecularFunctionamide transmembrane transporter activity

ABCC1 SLC38A7

5.36e-0342522GO:0042887
GeneOntologyMolecularFunctionABC-type transporter activity

ABCC1 ABCA1

7.23e-0349522GO:0140359
GeneOntologyMolecularFunctionpotassium ion transmembrane transporter activity

SLC24A4 ATP1A2 ATP1A4

9.41e-03167523GO:0015079
GeneOntologyBiologicalProcessamino acid neurotransmitter reuptake

SLC6A1 SLC6A12 SLC6A13 ATP1A2

6.89e-0910514GO:0051933
GeneOntologyBiologicalProcessneurotransmitter reuptake

SLC6A1 SLC6A12 SLC6A13 SLC6A5 ATP1A2

3.57e-0838515GO:0098810
GeneOntologyBiologicalProcessgamma-aminobutyric acid reuptake

SLC6A1 SLC6A12 SLC6A13

5.69e-084513GO:0051936
GeneOntologyBiologicalProcesstransport across blood-brain barrier

SLC6A1 ABCC1 SLC6A13 ATP8A1 ATP1A2 ATP1A4

7.31e-0887516GO:0150104
GeneOntologyBiologicalProcessvascular transport

SLC6A1 ABCC1 SLC6A13 ATP8A1 ATP1A2 ATP1A4

7.83e-0888516GO:0010232
GeneOntologyBiologicalProcessexport across plasma membrane

SLC35G1 ABCC1 ABCA1 SLC24A4 ATP1A2 ATP1A4

9.58e-0891516GO:0140115
GeneOntologyBiologicalProcessneurotransmitter uptake

SLC6A1 SLC6A12 SLC6A13 SLC6A5 ATP1A2

1.80e-0752515GO:0001504
GeneOntologyBiologicalProcessimport into cell

SLC6A1 MYD88 ABCC1 SLC6A12 SLC6A13 ABCA1 ATP8A1 RACK1 SLC24A4 SCAMP5 WNT3A SLC6A5 ATP1A2 ATP1A4

2.09e-0710745114GO:0098657
GeneOntologyBiologicalProcesssodium ion transport

SLC6A1 SLC6A12 SLC6A13 SLC24A4 SLC6A5 SLC38A7 ATP1A2 ATP1A4

3.50e-07275518GO:0006814
GeneOntologyBiologicalProcessmonoatomic ion transport

SLC6A1 SLC35G1 ABCC1 SLC6A12 SLC6A13 ATP8A1 SLCO4C1 SLC24A4 SLC26A7 WNT3A SLC6A5 SLC38A7 HTR3B ATP1A2 ATP1A4

6.80e-0713745115GO:0006811
GeneOntologyBiologicalProcesssodium ion transmembrane transport

SLC6A1 SLC6A12 SLC6A13 SLC24A4 SLC6A5 ATP1A2 ATP1A4

7.62e-07208517GO:0035725
GeneOntologyBiologicalProcessimport across plasma membrane

SLC6A1 ABCC1 SLC6A13 SLC24A4 SLC6A5 ATP1A2 ATP1A4

1.49e-06230517GO:0098739
GeneOntologyBiologicalProcessmonoatomic ion transmembrane transport

SLC6A1 SLC35G1 ABCC1 SLC6A12 SLC6A13 ATP8A1 SLC24A4 SLC26A7 WNT3A SLC6A5 HTR3B ATP1A2 ATP1A4

2.19e-0611155113GO:0034220
GeneOntologyBiologicalProcessorganic anion transport

SLC6A1 ABCC1 SLC6A12 SLC6A13 SLCO4C1 SLC26A7 SLC6A5 SLC38A7 ATP1A2

4.21e-06515519GO:0015711
GeneOntologyBiologicalProcesscarboxylic acid transport

SLC6A1 ABCC1 SLC6A12 SLC6A13 SLC26A7 SLC6A5 SLC38A7 ATP1A2

6.86e-06410518GO:0046942
GeneOntologyBiologicalProcessorganic acid transport

SLC6A1 ABCC1 SLC6A12 SLC6A13 SLC26A7 SLC6A5 SLC38A7 ATP1A2

7.11e-06412518GO:0015849
GeneOntologyBiologicalProcessamino acid transport

SLC6A1 SLC6A12 SLC6A13 SLC6A5 SLC38A7 ATP1A2

8.36e-06195516GO:0006865
GeneOntologyBiologicalProcessphospholipid translocation

ABCC1 ABCA1 ATP8A1 ATP8A2

1.03e-0555514GO:0045332
GeneOntologyBiologicalProcessamino acid transmembrane transport

SLC6A12 SLC6A13 SLC6A5 SLC38A7 ATP1A2

1.16e-05120515GO:0003333
GeneOntologyBiologicalProcesslipid translocation

ABCC1 ABCA1 ATP8A1 ATP8A2

1.46e-0560514GO:0034204
GeneOntologyBiologicalProcessmonoatomic cation transmembrane transport

SLC6A1 SLC35G1 SLC6A12 SLC6A13 ATP8A1 SLC24A4 WNT3A SLC6A5 HTR3B ATP1A2 ATP1A4

1.51e-059425111GO:0098655
GeneOntologyBiologicalProcessmonoatomic cation transport

SLC6A1 SLC35G1 SLC6A12 SLC6A13 ATP8A1 SLC24A4 WNT3A SLC6A5 SLC38A7 HTR3B ATP1A2 ATP1A4

1.90e-0511575112GO:0006812
GeneOntologyBiologicalProcessregulation of membrane lipid distribution

ABCC1 ABCA1 ATP8A1 ATP8A2

2.01e-0565514GO:0097035
GeneOntologyBiologicalProcessinorganic ion transmembrane transport

SLC6A1 SLC35G1 SLC6A12 SLC6A13 SLC24A4 SLC26A7 WNT3A SLC6A5 HTR3B ATP1A2 ATP1A4

3.07e-0510175111GO:0098660
GeneOntologyBiologicalProcessdetection of light stimulus

SLC24A4 ATP8A2 RRH GPR52

3.93e-0577514GO:0009583
GeneOntologyBiologicalProcessgamma-aminobutyric acid transport

SLC6A1 SLC6A12 SLC6A13

4.47e-0528513GO:0015812
GeneOntologyBiologicalProcesscarboxylic acid transmembrane transport

ABCC1 SLC6A13 SLC26A7 SLC6A5 ATP1A2

5.08e-05163515GO:1905039
GeneOntologyBiologicalProcessorganic acid transmembrane transport

ABCC1 SLC6A13 SLC26A7 SLC6A5 ATP1A2

5.70e-05167515GO:1903825
GeneOntologyBiologicalProcesssphingolipid translocation

ABCC1 ABCA1

5.97e-055512GO:0099039
GeneOntologyBiologicalProcessdetection of external stimulus

SLC24A4 ATP8A2 RRH NOX3 GPR52

6.73e-05173515GO:0009581
GeneOntologyBiologicalProcessdetection of abiotic stimulus

SLC24A4 ATP8A2 RRH NOX3 GPR52

7.11e-05175515GO:0009582
GeneOntologyBiologicalProcessinorganic cation transmembrane transport

SLC6A1 SLC35G1 SLC6A12 SLC6A13 SLC24A4 WNT3A SLC6A5 HTR3B ATP1A2 ATP1A4

7.30e-059225110GO:0098662
GeneOntologyBiologicalProcesspositive regulation of phospholipid translocation

ATP8A1 ATP8A2

8.93e-056512GO:0061092
GeneOntologyBiologicalProcessgamma-aminobutyric acid import

SLC6A1 SLC6A13

8.93e-056512GO:0051939
GeneOntologyBiologicalProcessclearance of foreign intracellular DNA

APOBEC3B APOBEC3F

8.93e-056512GO:0044355
GeneOntologyBiologicalProcessclearance of foreign intracellular nucleic acids

APOBEC3B APOBEC3F

8.93e-056512GO:0099046
GeneOntologyBiologicalProcessregulation of phospholipid translocation

ATP8A1 ATP8A2

1.25e-047512GO:0061091
GeneOntologyBiologicalProcessaminophospholipid translocation

ATP8A1 ATP8A2

1.25e-047512GO:0140331
GeneOntologyBiologicalProcessphospholipid transport

ABCC1 ABCA1 ATP8A1 ATP8A2

1.37e-04106514GO:0015914
GeneOntologyBiologicalProcessmetal ion transport

SLC6A1 SLC35G1 SLC6A12 SLC6A13 SLC24A4 WNT3A SLC6A5 SLC38A7 ATP1A2 ATP1A4

1.43e-0410005110GO:0030001
GeneOntologyBiologicalProcessmodified amino acid transport

ABCC1 SLC6A12 SLC6A13

1.76e-0444513GO:0072337
GeneOntologyBiologicalProcessvascular process in circulatory system

SLC6A1 ABCC1 SLC6A13 ATP8A1 ATP1A2 ATP1A4

1.97e-04344516GO:0003018
GeneOntologyBiologicalProcessaminophospholipid transport

ATP8A1 ATP8A2

2.13e-049512GO:0015917
GeneOntologyBiologicalProcessDNA cytosine deamination

APOBEC3B APOBEC3F

2.66e-0410512GO:0070383
GeneOntologyBiologicalProcessphototransduction

SLC24A4 RRH GPR52

3.06e-0453513GO:0007602
GeneOntologyBiologicalProcessestablishment or maintenance of transmembrane electrochemical gradient

ATP1A2 ATP1A4

3.25e-0411512GO:0010248
GeneOntologyBiologicalProcessacid secretion

SLC6A1 SLC26A7 CCKBR

3.79e-0457513GO:0046717
GeneOntologyBiologicalProcessdetection of visible light

ATP8A2 RRH GPR52

3.79e-0457513GO:0009584
GeneOntologyBiologicalProcesscytidine to uridine editing

APOBEC3B APOBEC3F

3.89e-0412512GO:0016554
GeneOntologyBiologicalProcesscalcium ion export across plasma membrane

SLC35G1 SLC24A4

3.89e-0412512GO:1990034
GeneOntologyBiologicalProcessamino acid import across plasma membrane

SLC6A13 SLC6A5 ATP1A2

3.99e-0458513GO:0089718
GeneOntologyBiologicalProcessinorganic ion import across plasma membrane

SLC6A1 SLC24A4 ATP1A2 ATP1A4

4.19e-04142514GO:0099587
GeneOntologyBiologicalProcessinorganic cation import across plasma membrane

SLC6A1 SLC24A4 ATP1A2 ATP1A4

4.19e-04142514GO:0098659
GeneOntologyBiologicalProcessneurotransmitter transport

SLC6A1 SLC6A12 SLC6A13 SLC6A5 ATP1A2

4.40e-04259515GO:0006836
GeneOntologyBiologicalProcesscytidine catabolic process

APOBEC3B APOBEC3F

5.35e-0414512GO:0006216
GeneOntologyBiologicalProcessDNA deamination

APOBEC3B APOBEC3F

5.35e-0414512GO:0045006
GeneOntologyBiologicalProcesscytidine metabolic process

APOBEC3B APOBEC3F

5.35e-0414512GO:0046087
GeneOntologyBiologicalProcesscytidine deamination

APOBEC3B APOBEC3F

5.35e-0414512GO:0009972
GeneOntologyBiologicalProcesssulfur compound transport

ABCC1 SLC6A13 SLC26A7

5.58e-0465513GO:0072348
GeneOntologyBiologicalProcesspositive regulation of phospholipid transport

ATP8A1 ATP8A2

6.17e-0415512GO:2001140
GeneOntologyBiologicalProcessphospholipid efflux

ABCC1 ABCA1

6.17e-0415512GO:0033700
GeneOntologyBiologicalProcessorganophosphate ester transport

ABCC1 ABCA1 ATP8A1 ATP8A2

6.87e-04162514GO:0015748
GeneOntologyBiologicalProcessnegative regulation of single stranded viral RNA replication via double stranded DNA intermediate

APOBEC3B APOBEC3F

7.04e-0416512GO:0045869
GeneOntologyBiologicalProcessregulation of phospholipid transport

ATP8A1 ATP8A2

7.04e-0416512GO:2001138
GeneOntologyBiologicalProcesspyrimidine ribonucleoside metabolic process

APOBEC3B APOBEC3F

7.04e-0416512GO:0046131
GeneOntologyBiologicalProcesspyrimidine ribonucleoside catabolic process

APOBEC3B APOBEC3F

7.04e-0416512GO:0046133
GeneOntologyBiologicalProcessgastric acid secretion

SLC26A7 CCKBR

7.04e-0416512GO:0001696
GeneOntologyBiologicalProcessintracellular potassium ion homeostasis

ATP1A2 ATP1A4

7.96e-0417512GO:0030007
GeneOntologyBiologicalProcesssodium ion export across plasma membrane

ATP1A2 ATP1A4

7.96e-0417512GO:0036376
GeneOntologyBiologicalProcesspyrimidine nucleoside catabolic process

APOBEC3B APOBEC3F

8.94e-0418512GO:0046135
GeneOntologyBiologicalProcessregulation of single stranded viral RNA replication via double stranded DNA intermediate

APOBEC3B APOBEC3F

9.98e-0419512GO:0045091
GeneOntologyBiologicalProcessbase conversion or substitution editing

APOBEC3B APOBEC3F

9.98e-0419512GO:0016553
GeneOntologyBiologicalProcesssingle stranded viral RNA replication via double stranded DNA intermediate

APOBEC3B APOBEC3F

1.11e-0320512GO:0039692
GeneOntologyBiologicalProcessacidic amino acid transport

SLC6A1 SLC6A13 ATP1A2

1.18e-0384513GO:0015800
GeneOntologyBiologicalProcesspore complex assembly

NDC1 GSDMD

1.47e-0323512GO:0046931
GeneOntologyBiologicalProcessribonucleoside catabolic process

APOBEC3B APOBEC3F

1.88e-0326512GO:0042454
GeneOntologyBiologicalProcessexport from cell

SLC35G1 ABCC1 ABCA1 SLC24A4 SCAMP5 GSDMD ATP1A2 ATP1A4 CCKBR

1.88e-031153519GO:0140352
GeneOntologyBiologicalProcessmonocarboxylic acid transport

ABCC1 SLC6A12 SLC6A13 SLC26A7

1.89e-03213514GO:0015718
GeneOntologyBiologicalProcessanterograde trans-synaptic signaling

SLC6A1 RNF19A WNT3A SLC6A5 HTR3B ATP1A2 ZDHHC17 CCKBR

1.90e-03931518GO:0098916
GeneOntologyBiologicalProcesschemical synaptic transmission

SLC6A1 RNF19A WNT3A SLC6A5 HTR3B ATP1A2 ZDHHC17 CCKBR

1.90e-03931518GO:0007268
GeneOntologyBiologicalProcessprotein lipidation

ABCA1 ZDHHC17 HHATL

2.00e-03101513GO:0006497
GeneOntologyBiologicalProcesstrans-synaptic signaling

SLC6A1 RNF19A WNT3A SLC6A5 HTR3B ATP1A2 ZDHHC17 CCKBR

2.00e-03939518GO:0099537
GeneOntologyBiologicalProcesspyrimidine nucleoside metabolic process

APOBEC3B APOBEC3F

2.02e-0327512GO:0006213
GeneOntologyBiologicalProcesspositive regulation of embryonic development

RACK1 WNT3A

2.02e-0327512GO:0040019
GeneOntologyBiologicalProcesspositive regulation of lipid transport

ABCA1 ATP8A1 ATP8A2

2.06e-03102513GO:0032370
GeneOntologyBiologicalProcesslipoprotein biosynthetic process

ABCA1 ZDHHC17 HHATL

2.30e-03106513GO:0042158
GeneOntologyBiologicalProcessresponse to light stimulus

SLC24A4 ATP8A2 RRH GPR52 ATP1A2

2.48e-03382515GO:0009416
GeneOntologyBiologicalProcessintracellular sodium ion homeostasis

ATP1A2 ATP1A4

2.49e-0330512GO:0006883
GeneOntologyBiologicalProcesssynaptic signaling

SLC6A1 RNF19A WNT3A SLC6A5 HTR3B ATP1A2 ZDHHC17 CCKBR

2.55e-03976518GO:0099536
GeneOntologyBiologicalProcesssynaptic vesicle recycling

ATP8A1 SCAMP5 WNT3A

2.62e-03111513GO:0036465
GeneOntologyBiologicalProcessDNA modification

APOBEC3B APOBEC3F

2.66e-0331512GO:0006304
GeneOntologyCellularComponentbasolateral plasma membrane

ABCC1 SLC6A12 SLC6A13 ABCA1 SLCO4C1 SLC26A7

1.38e-04320526GO:0016323
GeneOntologyCellularComponentbasal plasma membrane

ABCC1 SLC6A12 SLC6A13 ABCA1 SLCO4C1 SLC26A7

2.39e-04354526GO:0009925
GeneOntologyCellularComponentpresynapse

SLC6A1 SLC6A12 SLC6A13 ATP8A1 SCAMP5 WNT3A SLC6A5 FLRT2 ZDHHC17

3.02e-04886529GO:0098793
GeneOntologyCellularComponentbasal part of cell

ABCC1 SLC6A12 SLC6A13 ABCA1 SLCO4C1 SLC26A7

3.39e-04378526GO:0045178
GeneOntologyCellularComponentsodium:potassium-exchanging ATPase complex

ATP1A2 ATP1A4

3.94e-0412522GO:0005890
GeneOntologyCellularComponentphospholipid-translocating ATPase complex

ATP8A1 ATP8A2

5.42e-0414522GO:1990531
DomainNA_NEUROTRAN_SYMP_2

SLC6A1 SLC6A12 SLC6A13 SLC6A5

1.35e-0718504PS00754
DomainNA_NEUROTRAN_SYMP_3

SLC6A1 SLC6A12 SLC6A13 SLC6A5

1.71e-0719504PS50267
DomainSNF

SLC6A1 SLC6A12 SLC6A13 SLC6A5

1.71e-0719504PF00209
DomainNa/ntran_symport

SLC6A1 SLC6A12 SLC6A13 SLC6A5

1.71e-0719504IPR000175
DomainNA_NEUROTRAN_SYMP_1

SLC6A1 SLC6A12 SLC6A13 SLC6A5

1.71e-0719504PS00610
Domain-

ATP8A1 ATP8A2 ATP1A2 ATP1A4

1.55e-06325042.70.150.10
Domain-

ATP8A1 ATP8A2 ATP1A2 ATP1A4

1.55e-06325043.40.1110.10
DomainATPase_P-typ_cyto_domN

ATP8A1 ATP8A2 ATP1A2 ATP1A4

2.24e-0635504IPR023299
DomainATPase_P-typ_P_site

ATP8A1 ATP8A2 ATP1A2 ATP1A4

2.51e-0636504IPR018303
DomainP_typ_ATPase

ATP8A1 ATP8A2 ATP1A2 ATP1A4

2.51e-0636504IPR001757
DomainATPASE_E1_E2

ATP8A1 ATP8A2 ATP1A2 ATP1A4

2.51e-0636504PS00154
DomainATPase_P-typ_transduc_dom_A

ATP8A1 ATP8A2 ATP1A2 ATP1A4

2.81e-0637504IPR008250
DomainE1-E2_ATPase

ATP8A1 ATP8A2 ATP1A2 ATP1A4

2.81e-0637504PF00122
DomainHAD-like_dom

ATP8A1 ATP8A2 ATP1A2 ATP1A4

5.89e-0579504IPR023214
DomainSCAMP

SCAMP4 SCAMP5

6.99e-055502IPR007273
DomainSCAMP

SCAMP4 SCAMP5

6.99e-055502PF04144
DomainP-type_ATPase_IIC

ATP1A2 ATP1A4

1.05e-046502IPR005775
DomainMBOAT_fam

MBOAT1 HHATL

3.80e-0411502IPR004299
DomainMBOAT

MBOAT1 HHATL

3.80e-0411502PF03062
DomainAPOBEC_N

APOBEC3B APOBEC3F

4.56e-0412502PF08210
DomainAPOBEC_N

APOBEC3B APOBEC3F

4.56e-0412502IPR013158
DomainP_typ_ATPase_c

ATP8A1 ATP8A2

6.26e-0414502IPR032630
DomainP-type_ATPase_N

ATP8A1 ATP8A2

6.26e-0414502IPR032631
DomainP-type_ATPase_IV

ATP8A1 ATP8A2

6.26e-0414502IPR006539
DomainPhoLip_ATPase_C

ATP8A1 ATP8A2

6.26e-0414502PF16212
DomainPhoLip_ATPase_N

ATP8A1 ATP8A2

6.26e-0414502PF16209
DomainAPOBEC/CMP_deaminase_Zn-bd

APOBEC3B APOBEC3F

6.26e-0414502IPR016192
DomainCYT_DCMP_DEAMINASES_2

APOBEC3B APOBEC3F

7.21e-0415502PS51747
Domain-

ATP1A2 ATP1A4

8.23e-04165021.20.1110.10
DomainATPase_P-typ_TM_dom

ATP1A2 ATP1A4

8.23e-0416502IPR023298
DomainCYT_DCMP_DEAMINASES_1

APOBEC3B APOBEC3F

9.31e-0417502PS00903
DomainATPase_P-typ_cation-transptr_C

ATP1A2 ATP1A4

9.31e-0417502IPR006068
DomainCMP_dCMP_Zn-bd

APOBEC3B APOBEC3F

9.31e-0417502IPR002125
DomainCation_ATPase_C

ATP1A2 ATP1A4

9.31e-0417502PF00689
DomainCytidine_deaminase-like

APOBEC3B APOBEC3F

9.31e-0417502IPR016193
DomainCation_ATPase_N

ATP1A2 ATP1A4

1.05e-0318502PF00690
DomainCation_ATPase_N

ATP1A2 ATP1A4

1.05e-0318502SM00831
DomainATPase_P-typ_cation-transptr_N

ATP1A2 ATP1A4

1.17e-0319502IPR004014
DomainABC_transporter_CS

ABCC1 ABCA1

5.65e-0342502IPR017871
DomainABC_TRANSPORTER_2

ABCC1 ABCA1

7.32e-0348502PS50893
DomainABC_tran

ABCC1 ABCA1

7.32e-0348502PF00005
DomainABC_TRANSPORTER_1

ABCC1 ABCA1

7.62e-0349502PS00211
DomainABC_transporter-like

ABCC1 ABCA1

7.93e-0350502IPR003439
Domain-

ATP8A1 ATP8A2

1.27e-02645023.40.50.1000
PathwayREACTOME_TRANSPORT_OF_SMALL_MOLECULES

SLC6A1 ABCC1 SLC6A12 SLC6A13 ABCA1 ATP8A1 SLCO4C1 SLC24A4 SLC26A7 ATP8A2 SLC6A5 ATP1A2 ATP1A4

4.85e-086814213MM14985
PathwayREACTOME_TRANSPORT_OF_SMALL_MOLECULES

SLC6A1 ABCC1 SLC6A12 SLC6A13 ABCA1 ATP8A1 SLCO4C1 SLC24A4 SLC26A7 ATP8A2 SLC6A5 ATP1A2 ATP1A4

1.20e-077364213M27287
PathwayREACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS

SLC6A1 SLC6A12 SLC6A13 SLC6A5

2.55e-0719424M27362
PathwayREACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS

SLC6A1 SLC6A12 SLC6A13 SLC6A5

2.55e-0719424MM15107
PathwayREACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT

SLC6A1 SLC6A12 SLC6A13 SLCO4C1 SLC24A4 SLC26A7 SLC6A5

5.84e-06238427MM15076
PathwayREACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT

SLC6A1 SLC6A12 SLC6A13 SLCO4C1 SLC24A4 SLC26A7 SLC6A5

7.85e-06249427M5988
PathwayREACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES

ATP8A1 ATP8A2 ATP1A2 ATP1A4

2.08e-0555424M971
PathwayREACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION

SLC6A1 SLC6A12 SLC6A13

2.31e-0519423M927
PathwayREACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION

SLC6A1 SLC6A12 SLC6A13

2.31e-0519423MM15523
PathwayREACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES

ATP8A1 ATP8A2 ATP1A2 ATP1A4

2.40e-0557424MM15643
PathwayREACTOME_TRANSPORT_OF_BILE_SALTS_AND_ORGANIC_ACIDS_METAL_IONS_AND_AMINE_COMPOUNDS

SLC6A1 SLC6A12 SLC6A13 SLC6A5

7.47e-0576424MM15072
PathwayREACTOME_TRANSPORT_OF_BILE_SALTS_AND_ORGANIC_ACIDS_METAL_IONS_AND_AMINE_COMPOUNDS

SLC6A1 SLC6A12 SLC6A13 SLC6A5

1.10e-0484424M27334
PathwayREACTOME_MRNA_EDITING_C_TO_U_CONVERSION

APOBEC3B APOBEC3F

1.80e-047422MM15412
PathwayREACTOME_MRNA_EDITING

APOBEC3B APOBEC3F

3.08e-049422MM15445
PathwayREACTOME_NEUROTRANSMITTER_RELEASE_CYCLE

SLC6A1 SLC6A12 SLC6A13

4.64e-0451423M4281
PathwayREACTOME_NEUROTRANSMITTER_RELEASE_CYCLE

SLC6A1 SLC6A12 SLC6A13

4.64e-0451423MM14499
PathwayWP_SREBF_AND_MIR33_IN_CHOLESTEROL_AND_LIPID_HOMEOSTASIS

ABCA1 SCD

1.29e-0318422M39679
Pubmed

Blood-Brain Barrier: From Physiology to Disease and Back.

SLC6A1 ABCC1 SLC6A13 ATP8A1 ATP1A2 ATP1A4

1.19e-0810552630280653
Pubmed

Molecular characterization of four pharmacologically distinct gamma-aminobutyric acid transporters in mouse brain [corrected].

SLC6A1 SLC6A12 SLC6A13

1.26e-0845238420981
Pubmed

The repertoire of solute carriers of family 6: identification of new human and rodent genes.

SLC6A1 SLC6A12 SLC6A13 SLC6A5

2.61e-082152416125675
Pubmed

Embryonic and postnatal expression of four gamma-aminobutyric acid transporter mRNAs in the mouse brain and leptomeninges.

SLC6A1 SLC6A12 SLC6A13

3.15e-0855238956109
Pubmed

Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.

SLC6A1 SLC6A12 SLC6A13 SLC6A5 HTR3B SERPINA6 CCKBR

3.18e-0730052719086053
Pubmed

LXR-mediated activation of macrophage stearoyl-CoA desaturase generates unsaturated fatty acids that destabilize ABCA1.

ABCA1 SCD

2.19e-06252214967823
Pubmed

Interactive effect between ATPase-related genes and early-life tobacco smoke exposure on bronchial hyper-responsiveness detected in asthma-ascertained families.

ABCA1 ATP8A1

2.19e-06252230282721
Pubmed

The Na,K-ATPase alpha4 gene (Atp1a4) encodes a ouabain-resistant alpha subunit and is tightly linked to the alpha2 gene (Atp1a2) on mouse chromosome 1.

ATP1A2 ATP1A4

2.19e-06252210555956
Pubmed

Evidence for a Revised Ion/Substrate Coupling Stoichiometry of GABA Transporters.

SLC6A1 SLC6A13

2.19e-06252225824654
Pubmed

GABA neurotransmitter signaling in the developing mouse lens: dynamic regulation of components and functionality.

SLC6A1 SLC6A12 SLC6A13

2.53e-061852318985723
Pubmed

Murine Leukemia Virus P50 Protein Counteracts APOBEC3 by Blocking Its Packaging.

APOBEC3B APOBEC3F

6.57e-06352232641479
Pubmed

APOBEC3 deletion increases the risk of breast cancer: a meta-analysis.

APOBEC3B APOBEC3F

6.57e-06352227602762
Pubmed

A novel role for APOBEC3: susceptibility to sexual transmission of murine acquired immunodeficiency virus (mAIDS) is aggravated in APOBEC3 deficient mice.

APOBEC3B APOBEC3F

6.57e-06352222691411
Pubmed

Studies on the restriction of murine leukemia viruses by mouse APOBEC3.

APOBEC3B APOBEC3F

6.57e-06352222666481
Pubmed

APOBEC3 deletion polymorphism is associated with epithelial ovarian cancer risk among Chinese women.

APOBEC3B APOBEC3F

6.57e-06352224577894
Pubmed

APOBEC3B and APOBEC3F inhibit L1 retrotransposition by a DNA deamination-independent mechanism.

APOBEC3B APOBEC3F

6.57e-06352216648136
Pubmed

Fv1 restriction and retrovirus vaccine immunity in Apobec3-deficient 129P2 mice.

APOBEC3B APOBEC3F

6.57e-06352223533681
Pubmed

Spontaneous recovery from Friend retrovirus-induced leukemia. Mapping of the Rfv-2 gene in the Q/TL region of mouse MHC.

APOBEC3B APOBEC3F

6.57e-0635221541833
Pubmed

In Vivo Examination of Mouse APOBEC3- and Human APOBEC3A- and APOBEC3G-Mediated Restriction of Parvovirus and Herpesvirus Infection in Mouse Models.

APOBEC3B APOBEC3F

6.57e-06352227356895
Pubmed

IFN-α treatment inhibits acute Friend retrovirus replication primarily through the antiviral effector molecule Apobec3.

APOBEC3B APOBEC3F

6.57e-06352223315078
Pubmed

Requirement for Fc effector mechanisms in the APOBEC3/Rfv3-dependent neutralizing antibody response.

APOBEC3B APOBEC3F

6.57e-06352225589647
Pubmed

Murine leukemia virus glycosylated Gag blocks apolipoprotein B editing complex 3 and cytosolic sensor access to the reverse transcription complex.

APOBEC3B APOBEC3F

6.57e-06352223671100
Pubmed

Structural perspectives on HIV-1 Vif and APOBEC3 restriction factor interactions.

APOBEC3B APOBEC3F

6.57e-06352231518043
Pubmed

APOBEC3 signature mutations in chronic lymphocytic leukemia.

APOBEC3B APOBEC3F

6.57e-06352224840555
Pubmed

Requirement for CD4(+) T cells in the Friend murine retrovirus neutralizing antibody response: evidence for functional T cells in genetic low-recovery mice.

APOBEC3B APOBEC3F

6.57e-0635229765497
Pubmed

Biochemical and biological studies of mouse APOBEC3.

APOBEC3B APOBEC3F

6.57e-06352224453360
Pubmed

Function of prokaryotic and eukaryotic ABC proteins in lipid transport.

ABCC1 ABCA1

6.57e-06352215749056
Pubmed

APOBEC3 inhibition of mouse mammary tumor virus infection: the role of cytidine deamination versus inhibition of reverse transcription.

APOBEC3B APOBEC3F

6.57e-06352223449789
Pubmed

Plasmalemmal and vesicular gamma-aminobutyric acid transporter expression in the developing mouse retina.

SLC6A1 SLC6A13

6.57e-06352218975268
Pubmed

APOBEC3-independent interferon-induced viral clearance in hepatitis B virus transgenic mice.

APOBEC3B APOBEC3F

6.57e-06352218434399
Pubmed

Induction of APOBEC3 in vivo causes increased restriction of retrovirus infection.

APOBEC3B APOBEC3F

6.57e-06352219153238
Pubmed

Apobec3 encodes Rfv3, a gene influencing neutralizing antibody control of retrovirus infection.

APOBEC3B APOBEC3F

6.57e-06352218772436
Pubmed

Mouse APOBEC3 restricts friend leukemia virus infection and pathogenesis in vivo.

APOBEC3B APOBEC3F

6.57e-06352218786991
Pubmed

Anti-Friend virus antibody is associated with recovery from viremia and loss of viral leukemia cell-surface antigens in leukemic mice. Identification of Rfv-3 as a gene locus influencing antibody production.

APOBEC3B APOBEC3F

6.57e-063522286744
Pubmed

Host restriction of murine gammaherpesvirus 68 replication by human APOBEC3 cytidine deaminases but not murine APOBEC3.

APOBEC3B APOBEC3F

6.57e-06352224725948
Pubmed

The glycosylated Gag protein of a murine leukemia virus inhibits the antiretroviral function of APOBEC3.

APOBEC3B APOBEC3F

6.57e-06352220702647
Pubmed

Macrophage ABCA1 reduces MyD88-dependent Toll-like receptor trafficking to lipid rafts by reduction of lipid raft cholesterol.

MYD88 ABCA1

6.57e-06352220650929
Pubmed

Astrocytic γ-aminobutyric acid (GABA) transporters mediate guanidinoacetate transport in rat brain.

SLC6A12 SLC6A13

6.57e-06352229175673
Pubmed

Persistent Friend virus replication and disease in Apobec3-deficient mice expressing functional B-cell-activating factor receptor.

APOBEC3B APOBEC3F

6.57e-06352220980520
Pubmed

Identification of a non-H-2 gene (Rfv-3) influencing recovery from viremia and leukemia induced by Friend virus complex.

APOBEC3B APOBEC3F

6.57e-063522284359
Pubmed

Adaptive evolution of Mus Apobec3 includes retroviral insertion and positive selection at two clusters of residues flanking the substrate groove.

APOBEC3B APOBEC3F

6.57e-06352220617165
Pubmed

Impact of Suboptimal APOBEC3G Neutralization on the Emergence of HIV Drug Resistance in Humanized Mice.

APOBEC3B APOBEC3F

6.57e-06352231801862
Pubmed

Apobec-mediated retroviral hypermutation in vivo is dependent on mouse strain.

APOBEC3B APOBEC3F

6.57e-06352239208378
Pubmed

Deamination hotspots among APOBEC3 family members are defined by both target site sequence context and ssDNA secondary structure.

APOBEC3B APOBEC3F

6.57e-06352231943071
Pubmed

Innate retroviral restriction by Apobec3 promotes antibody affinity maturation in vivo.

APOBEC3B APOBEC3F

6.57e-06352220566830
Pubmed

APOBEC-mediated viral restriction: not simply editing?

APOBEC3B APOBEC3F

6.57e-06352217303427
Pubmed

Developmental expression of the neurotransmitter transporter GAT3.

SLC6A1 SLC6A13

6.57e-06352210348670
Pubmed

Chromosome mapping of Rfv3, a host resistance gene to Friend murine retrovirus.

APOBEC3B APOBEC3F

6.57e-0635227884913
Pubmed

N-linked glycosylation protects gammaretroviruses against deamination by APOBEC3 proteins.

APOBEC3B APOBEC3F

6.57e-06352225505062
Pubmed

Molecular analysis of γ1, γ3, and α class switch recombination junctions in APOBEC3-deficient mice using high-throughput sequencing.

APOBEC3B APOBEC3F

6.57e-06352231595054
Pubmed

Role of APOBEC3 in genetic diversity among endogenous murine leukemia viruses.

APOBEC3B APOBEC3F

6.57e-06352217967065
Pubmed

Inhibition of xenotropic murine leukemia virus-related virus by APOBEC3 proteins and antiviral drugs.

APOBEC3B APOBEC3F

6.57e-06352220335265
Pubmed

Deaminase-Dead Mouse APOBEC3 Is an In Vivo Retroviral Restriction Factor.

APOBEC3B APOBEC3F

6.57e-06352229593034
Pubmed

Mouse APOBEC3 interferes with autocatalytic cleavage of murine leukemia virus Pr180gag-pol precursor and inhibits Pr65gag processing.

APOBEC3B APOBEC3F

6.57e-06352231830125
Pubmed

Noninfectious retrovirus particles drive the APOBEC3/Rfv3 dependent neutralizing antibody response.

APOBEC3B APOBEC3F

6.57e-06352221998583
Pubmed

Direct inhibition of human APOBEC3 deaminases by HIV-1 Vif independent of the proteolysis pathway.

APOBEC3B APOBEC3F

6.57e-06352238115583
Pubmed

Stearoyl-CoA Desaturase 1 (SCD1) is a key factor mediating diabetes in MyD88-deficient mice.

MYD88 SCD

6.57e-06352222326531
Pubmed

Effects of zidovudine on Friend virus complex infection in Rfv-3r/s genotype-containing mice used as a model for HIV infection.

APOBEC3B APOBEC3F

6.57e-0635222157836
Pubmed

Distinctive High Expression of Antiretroviral APOBEC3 Protein in Mouse Germinal Center B Cells.

APOBEC3B APOBEC3F

6.57e-06352235458563
Pubmed

Natural resistance to HIV infection: The Vif-APOBEC interaction.

APOBEC3B APOBEC3F

6.57e-06352217067930
Pubmed

Increased cellular free cholesterol in macrophage-specific Abca1 knock-out mice enhances pro-inflammatory response of macrophages.

MYD88 ABCA1

6.57e-06352218552351
Pubmed

Two genetic determinants acquired late in Mus evolution regulate the inclusion of exon 5, which alters mouse APOBEC3 translation efficiency.

APOBEC3B APOBEC3F

6.57e-06352222275865
Pubmed

Transport through recycling endosomes requires EHD1 recruitment by a phosphatidylserine translocase.

ATP8A1 ATP8A2

6.57e-06352225595798
Pubmed

Antibody-induced modulation of Friend virus cell surface antigens decreases virus production by persistent erythroleukemia cells: influence of the Rfv-3 gene.

APOBEC3B APOBEC3F

6.57e-063522293683
Pubmed

Enhanced replication and pathogenesis of Moloney murine leukemia virus in mice defective in the murine APOBEC3 gene.

APOBEC3B APOBEC3F

6.57e-06352219150103
Pubmed

Initial sequencing and comparative analysis of the mouse genome.

APOBEC3B APOBEC3F

6.57e-06352212466850
Pubmed

Biology, structure and mechanism of P-type ATPases.

ATP8A1 ATP1A2 ATP1A4

1.12e-052952315071553
Pubmed

Murine APOBEC1 is a powerful mutator of retroviral and cellular RNA in vitro and in vivo.

APOBEC3B APOBEC3F

1.31e-05452218983852
Pubmed

APOBEC3 regulates keratinocyte differentiation and expression of Notch3.

APOBEC3B APOBEC3F

1.31e-05452231400166
Pubmed

Ribonuclease L is not critical for innate restriction and adaptive immunity against Friend retrovirus infection.

APOBEC3B APOBEC3F

1.31e-05452223725696
Pubmed

APOBEC3G promotes liver metastasis in an orthotopic mouse model of colorectal cancer and predicts human hepatic metastasis.

APOBEC3B APOBEC3F

1.31e-05452221985787
Pubmed

APOBEC3A functions as a restriction factor of human papillomavirus.

APOBEC3B APOBEC3F

1.31e-05452225355878
Pubmed

Human and murine APOBEC3s restrict replication of koala retrovirus by different mechanisms.

APOBEC3B APOBEC3F

1.31e-05452226253512
Pubmed

Reversed functional organization of mouse and human APOBEC3 cytidine deaminase domains.

APOBEC3B APOBEC3F

1.31e-05452217020885
Pubmed

Persistence of viremia and production of neutralizing antibodies differentially regulated by polymorphic APOBEC3 and BAFF-R loci in friend virus-infected mice.

APOBEC3B APOBEC3F

1.31e-05452220375169
Pubmed

APOBEC3 proteins expressed in mammary epithelial cells are packaged into retroviruses and can restrict transmission of milk-borne virions.

APOBEC3B APOBEC3F

1.31e-05452221147467
Pubmed

Mice deficient in APOBEC2 and APOBEC3.

APOBEC3B APOBEC3F

1.31e-05452216055735
Pubmed

The incorporation of APOBEC3 proteins into murine leukemia viruses.

APOBEC3B APOBEC3F

1.31e-05452218572219
Pubmed

Preactivation of AMPK by metformin may ameliorate the epithelial cell damage caused by renal ischemia.

ATP1A2 ATP1A4

1.31e-05452221849490
Pubmed

Restriction of foamy viruses by APOBEC cytidine deaminases.

APOBEC3B APOBEC3F

1.31e-05452216378963
Pubmed

Multifaceted HIV-1 Vif interactions with human E3 ubiquitin ligase and APOBEC3s.

APOBEC3B APOBEC3F

1.31e-05452232893454
Pubmed

Ancient adaptive evolution of the primate antiviral DNA-editing enzyme APOBEC3G.

APOBEC3B APOBEC3F

1.31e-05452215269786
Pubmed

Immunoglobulin somatic hypermutation by APOBEC3/Rfv3 during retroviral infection.

APOBEC3B APOBEC3F

1.31e-05452224821801
Pubmed

Small molecular compounds inhibit HIV-1 replication through specifically stabilizing APOBEC3G.

APOBEC3B APOBEC3F

1.31e-05452220363737
Pubmed

Expression and subcellular localisation of AID and APOBEC3 in adenoid and palatine tonsils.

APOBEC3B APOBEC3F

1.31e-05452229343743
Pubmed

Hypotaurine Is a Substrate of GABA Transporter Family Members GAT2/Slc6a13 and TAUT/Slc6a6.

SLC6A1 SLC6A13

1.31e-05452230270321
Pubmed

APOBEC3G cytidine deaminase inhibits retrotransposition of endogenous retroviruses.

APOBEC3B APOBEC3F

1.31e-05452215674295
Pubmed

Virus-specific CD8+ T cells upregulate programmed death-1 expression during acute friend retrovirus infection but are highly cytotoxic and control virus replication.

APOBEC3B APOBEC3F

1.31e-05452221873525
Pubmed

APOBEC3 enzymes restrict marginal zone B cells.

APOBEC3B APOBEC3F

1.31e-05452225501566
Pubmed

Restriction by APOBEC3 proteins of endogenous retroviruses with an extracellular life cycle: ex vivo effects and in vivo "traces" on the murine IAPE and human HERV-K elements.

APOBEC3B APOBEC3F

1.31e-05452218702815
Pubmed

HIV-1 Vif versus the APOBEC3 cytidine deaminases: an intracellular duel between pathogen and host restriction factors.

APOBEC3B APOBEC3F

1.31e-05452220538015
Pubmed

Exocytosis regulates trafficking of GABA and glycine heterotransporters in spinal cord glutamatergic synapses: a mechanism for the excessive heterotransporter-induced release of glutamate in experimental amyotrophic lateral sclerosis.

SLC6A1 SLC6A5

1.31e-05452225497732
Pubmed

ABCA1 and ABCG1 protect against oxidative stress-induced macrophage apoptosis during efferocytosis.

MYD88 ABCA1

1.31e-05452220431058
Pubmed

The role of APOBEC3B in lung tumor evolution and targeted cancer therapy resistance.

APOBEC3B APOBEC3F

1.31e-05452238049664
Pubmed

Tetherin/BST-2 promotes dendritic cell activation and function during acute retrovirus infection.

APOBEC3B APOBEC3F

1.31e-05452226846717
Pubmed

Vaccinia virus replication is not affected by APOBEC3 family members.

APOBEC3B APOBEC3F

1.31e-05452217052331
Pubmed

Type I interferon signaling is required for the APOBEC3/Rfv3-dependent neutralizing antibody response but not innate retrovirus restriction.

APOBEC3B APOBEC3F

1.31e-05452228415995
Pubmed

Immunity to retroviral infection: the Friend virus model.

APOBEC3B APOBEC3F

1.31e-0545229223268
Pubmed

Species-specific restriction of apobec3-mediated hypermutation.

APOBEC3B APOBEC3F

1.31e-05452218032489
Pubmed

Reassessment of murine APOBEC1 as a retrovirus restriction factor in vivo.

APOBEC3B APOBEC3F

1.31e-05452225303118
InteractionSLC10A6 interactions

CYB5B SCAMP4 SCAMP5 TMEM208 SCD SLC38A7

5.84e-06179516int:SLC10A6
InteractionGPR152 interactions

CYB5B SCAMP4 TMEM208 SCD SLC38A7 HHATL

1.04e-05198516int:GPR152
GeneFamilySolute carriers

SLC6A1 SLC35G1 SLC6A12 SLC6A13 SLCO4C1 SLC24A4 SLC26A7 SLC6A5 SLC38A7

2.44e-07395429752
GeneFamilySecretory carrier membrane proteins

SCAMP4 SCAMP5

5.24e-055422735
GeneFamilyMembrane bound O-acyltransferases

MBOAT1 HHATL

1.10e-0474221036
GeneFamilyATPase Na+/K+ transporting subunits

ATP1A2 ATP1A4

1.10e-0474221208
GeneFamilyApolipoprotein B mRNA editing enzyme catalytic subunits

APOBEC3B APOBEC3F

3.43e-0412422406
GeneFamilyATPase phospholipid transporting

ATP8A1 ATP8A2

5.43e-04154221210
ToppCellStriatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Adora2a-Excitatory_Neuron.Gad1Gad2.Adora2a-Fos_(iSPN,_IEG+)|Striatum / BrainAtlas - Mouse McCarroll V32

ODF4 SLC26A7 WNT3A RRH

6.89e-0759524a72de8cda377c87fa9a6fbda72735d850650f9f4
ToppCellStriatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Adora2a-Excitatory_Neuron.Gad1Gad2.Adora2a-Fos_(iSPN,_IEG+)-|Striatum / BrainAtlas - Mouse McCarroll V32

ODF4 SLC26A7 WNT3A RRH

6.89e-07595243ab024fa7a927177da0dc764cee46dabdd008040
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SLC6A1 SLC35G1 SLC6A12 SLCO4C1 RALGPS2

1.63e-061705255570c0e825bca77613bf0ebde620cf744fa1cb84
ToppCellfacs-Marrow-T_cells-18m-Lymphocytic-immature_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCD ATP1A2 SERPINA6 HHATL

3.83e-0516252422f1abd20f43bc7e7fc46969da9962faf70ae5d2
ToppCellfacs-Marrow-T_cells-18m-Lymphocytic-immature_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCD ATP1A2 SERPINA6 HHATL

3.83e-05162524966df4558140c3d541999ab553f201ae76a1c401
ToppCellE16.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1/AT2|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SLC6A13 ATP8A1 SLC26A7 DISP2

4.02e-05164524b6beb8548ac0dd07e8a580a938e5ee4bf25a3c1f
ToppCellE16.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1/AT2-AT1/AT2_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SLC6A13 ATP8A1 SLC26A7 DISP2

4.02e-05164524fe11fcce4ba7f44ba2989ea3705916b67e75f8e7
ToppCellThalamus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Gata3_(Periacqueductal_gray_(PAG)_(or_adjacent_APTD))--|Thalamus / BrainAtlas - Mouse McCarroll V32

WNT3A RRH CD200R1L

4.08e-05575239614fe2acc6ee039383504f94bbe6d35aac27f25
ToppCellThalamus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Gata3_(Periacqueductal_gray_(PAG)_(or_adjacent_APTD))-|Thalamus / BrainAtlas - Mouse McCarroll V32

WNT3A RRH CD200R1L

4.08e-05575233c55a5598a7ea789500f2fbd35c79d2b97a3fc7d
ToppCellThalamus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Gata3_(Periacqueductal_gray_(PAG)_(or_adjacent_APTD))|Thalamus / BrainAtlas - Mouse McCarroll V32

WNT3A RRH CD200R1L

4.08e-0557523309b3d48bfe215d7b581722c06d444b5b2ef6a30
ToppCell10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-Pericyte-B|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SLC6A1 SLC6A12 SLC6A13 ATP1A2

4.73e-05171524a4a2c5dc995589fbe3d4ca6ee1df888807e4ae34
ToppCelldroplet-Bladder-nan-24m-Epithelial-nan|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC6A13 SLCO4C1 SCD ATP1A2

5.65e-05179524dfd9d29281510d32f1a2e8336d2e58ef496cfd1d
ToppCellAnterior_Cingulate_gyrus_(CgG)-Non-neuronal-Mesenchymal-Mes-Pericyte-Peri_L1-6_MUSTN1|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SLC6A12 MBOAT1 GSDMD ATP1A2

6.03e-05182524406abe0e2958c73ff0f8bfbf7e6183dd6a53db0f
ToppCellAnterior_Cingulate_gyrus_(CgG)-Non-neuronal-Mesenchymal-Mes-Pericyte|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SLC6A12 MBOAT1 GSDMD ATP1A2

6.03e-05182524a71054800e7696ae39b03b11aac2991fb5d54fad
ToppCellCD8+_Memory_T_cell-CV-7|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster

NDC1 ATP8A1 RNF19A ZDHHC17

7.27e-051915249454f642c3621370fa23640b631301346b300950
ToppCell10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-C|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SLC6A1 ATP8A1 SCD HHATL

7.41e-051925243ce5dbde41aeb73d49f2c7991d34682f0827fa5a
ToppCellnormal_Lung-Epithelial_cells-AT2|Epithelial_cells / Location, Cell class and cell subclass

RACK1 SLCO4C1 SCD ATP8A2

7.87e-0519552481e13fe337f1d0a83d0deb86a0df797d306cd24d
ToppCellThalamus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6|Thalamus / BrainAtlas - Mouse McCarroll V32

SLC24A4 ODF4 SLC26A7

7.87e-05715237623b110bc3db0f5b99803c8fbb881ae8846b817
ToppCelldistal-2-Hematologic-B_cell|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SCAMP5 ATP8A2 RALGPS2 APOBEC3B

8.03e-051965242587b5d83fb4f1c4a69894aa0f5f7cb3898faa09
DrugNO-711

SLC6A1 SLC6A12 SLC6A13 MGAT2 SLC6A5

3.72e-0766515CID000004515
Drugbornane

SLC6A1 SLC6A12 SLC6A13

1.73e-0611513CID000092108
Drugamoxapine

SLC6A1 CYB5B SLC6A13 SLC6A5

3.40e-0646514CID000002170
Drugbetaine

SLC6A1 SLC6A12 SLC6A13 MGAT2 SLC6A5 HTR3B

5.52e-06200516CID000000247
Drugsodium

SLC6A1 SLC6A12 SLC6A13 SLC24A4 SLC26A7 ATP8A2 SLC6A5 SLC38A7 ATP1A2 ATP1A4 SERPINA6

6.10e-069445111CID000000923
DrugCGP 52432

SLC6A1 SLC6A13 SLC6A5

1.37e-0521513CID000132252
DrugGaba-Glu

SLC6A1 SLC6A13

1.47e-053512CID000129795
DrugASPAN

SLC6A1 SLC6A13

1.47e-053512CID005475577
DrugAC1Q5UBL

SLC6A1 SLC6A12 SLC6A13 MGAT2 SLC6A5

1.88e-05146515CID000005466
Drugmosapride

SLC6A1 SLC6A13 HTR3B

2.65e-0526513CID000119583
Drug2-(2 aminothiazol-4-yl)acetic acid

SLC6A1 SLC6A13

2.94e-054512CID000034665
Drug2,4-diaminobutyric acid

SLC6A1 SLC6A12 SLC6A13

3.71e-0529513CID000000470
Drugguvacine

SLC6A1 SLC6A12 SLC6A13

4.12e-0530513CID000003532
DrugHis-pro-dkp

SLC6A1 SLC6A13 SLC6A5

4.55e-0531513CID000065137
Drughypotaurine

SLC6A1 SLC6A12 SLC6A13

4.55e-0531513CID000107812
DrugCI-966

SLC6A1 SLC6A13

4.90e-055512CID000198692
Drugtert-butyl glutaminate

SLC6A1 SLC6A12 SLC6A13

6.03e-0534513CID003450458
Drugsipatrigine

SLC6A1 SLC6A13 SLC6A5

7.80e-0537513CID000060803
Drugbeta-alanine

SLC6A1 SLC6A12 SLC6A13 SLC6A5

8.70e-05104514CID000000239
DrugSKF 100330A

SLC6A1 SLC6A13

1.03e-047512CID000134985
Drugsomatoprim

SLC6A1 SLC6A13

1.03e-047512CID000001695
Drugchlorine cation

SLC6A1 SLC6A13

1.03e-047512CID006857643
Drugbumetanide

SLC6A1 SLC6A13 SLC26A7 SLC6A5 ATP1A2

1.04e-04209515CID000002471
Drugdesvenlafaxine

SLC6A1 SLC6A13 SLC6A5

1.06e-0441513CID000125017
DrugC0761

APOBEC3B APOBEC3F

1.37e-048512CID006321196
DrugN-cyclopropylammelide

APOBEC3B APOBEC3F

1.37e-048512CID000592814
Drugtiagabine

SLC6A1 ABCC1

1.37e-048512ctd:C059205
Drugtaurine

SLC6A1 SLC6A12 SLC6A13 SLC6A5 ATP1A2

1.65e-04231515CID000001123
Diseasefamilial hemiplegic migraine (implicated_via_orthology)

ATP1A2 ATP1A4

6.12e-057512DOID:0060178 (implicated_via_orthology)
Diseaseepilepsy (implicated_via_orthology)

SLC24A4 SCAMP5 ATP1A2 ATP1A4

1.83e-04163514DOID:1826 (implicated_via_orthology)
Diseasedecanoylcarnitine measurement

SLC6A1 ABCC1

1.91e-0412512EFO_0021039
Diseasenervous system disease (implicated_via_orthology)

ATP1A2 ATP1A4

1.91e-0412512DOID:863 (implicated_via_orthology)
Diseaseimidazole lactate measurement

SLC6A13 SLC38A7

2.26e-0413512EFO_0800004
Diseasecortisol measurement

CD200R1L SERPINA6

5.46e-0420512EFO_0005843
Disease3-hydroxybutyrate measurement

ABCA1 SERPINA6

8.57e-0425512EFO_0010982
DiseaseEncephalopathies

SLC6A5 ATP1A2

1.00e-0327512C0085584

Protein segments in the cluster

PeptideGeneStartEntry
PAYKCFQITWFVSWT

APOBEC3B

81

Q9UH17
IYTITLCSLWALWGG

HTR3B

426

O95264
PYCLVVRKPSSSWFW

GSDMD

36

P57764
SGVKPVIYWLSNFVW

ABCA1

1691

O95477
LFFLCWLPVYSANTW

CCKBR

341

P32239
PCGVIKFRYIWICWF

DISP2

696

A7MBM2
CSIKWVTEWLKYIPS

FLRT2

316

O43155
TVCLKAGLETSYWTW

ATP8A1

991

Q9Y2Q0
LTWLVFFGIYSTIWP

ATP8A2

1036

Q9NTI2
KWVFTWPLIFLLCVT

SLC24A4

426

Q8NFF2
YWLCAATGPSIKIWD

RACK1

246

P63244
VAWSPYSIVCLWASF

RRH

251

O14718
SIPIGWSYFIGWLVL

ODF4

176

Q2M2E3
DKPIGTWLLYLPCTW

COQ2

81

Q96H96
TWLLYLPCTWSIGLA

COQ2

86

Q96H96
TTLWLGPCDIVYLWS

HHATL

376

Q9HCP6
WDWTLQYLTVSCLPK

MGAT2

346

Q10469
YWGNGTVTVKSTCPW

CD200R1L

186

Q6Q8B3
YTNPCTKSWFWTRLA

MYD88

276

Q99836
WIYSCLIFLPSFFGW

GPR52

166

Q9Y2T5
LPDVCYSWWVLASLK

RABGGTB

236

P53611
AYKCFQITWFVSWTP

APOBEC3F

81

Q8IUX4
KVTWWFCAFPYSLLI

ATP1A2

981

P50993
LTPWVKFLWESYRQC

EIF3A

146

Q14152
DTSVTVIWYGKKWPC

FBXO15

221

Q8NCQ5
VIWYGKKWPCLASLS

FBXO15

226

Q8NCQ5
SCWAYWILPIIGAVL

CYB5B

121

O43169
WKPLWLCGYGLTQST

GRHPR

141

Q9UBQ7
PWYPTVLTFILSALW

MBOAT1

366

Q6ZNC8
GLWWTYVCSLVFKAS

GJB5

126

O95377
VWLLLFTPCGYVCWF

SCAMP4

76

Q969E2
LWLILFTPCSYVCWF

SCAMP5

76

Q8TAC9
YTCLLWLPTSGLWTV

SERPINA6

6

P08185
PTVASWTKYWAALCG

RALGPS2

476

Q86X27
TVLVWVPCFYLWACF

ABCC1

36

P33527
WKLCWSFFTPIIVAG

SLC6A1

496

P30531
FWKVCWAFVTPTILT

SLC6A5

676

Q9Y345
WVICYFCIWKGVKST

SLC6A12

221

P48065
CYLPSAWVLVGLASW

PRSS47P

281

A8MTI9
KPASWWVLVSYGVLL

SLC38A7

426

Q9NVC3
SAWKWILGPVVLYAC

NOX3

266

Q9HBY0
ITWWLCAIPYSILIF

ATP1A4

991

Q13733
YLSPSGCTFWGKKPW

RNF19A

341

Q9NV58
SWIFAWSLIIPFSCF

SLCO4C1

321

Q6ZQN7
WVICYFCIWKGVKST

SLC6A13

216

Q9NSD5
TLIPTCKFYTWLWGV

SCD

91

O00767
SCFSLYVWSFWLLAP

TMEM208

116

Q9BTX3
GFWTYITQIATCSPW

ZDHHC17

516

Q8IUH5
CSLKQALGSYPIWWS

WNT3A

11

P56704
SIFAWICLKEKYSPW

SLC35G1

171

Q2M3R5
IDWGIWVSTYVFTIC

SLC26A7

436

Q8TE54
VTSFYWPWQTKVILD

PTGR2

96

Q8N8N7
VYLPLLWEQSFCWKS

ZRANB1

561

Q9UGI0
CGVFLLTTWYVSWIL

NDC1

276

Q9BTX1