Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	single-stranded DNA endodeoxyribonuclease activity	RBBP8 XRCC4 POLQ	1.25e-05	13	72	3	GO:0000014
GeneOntologyMolecularFunction	histone reader activity	BRDT MSL3 ZZEF1	1.10e-04	26	72	3	GO:0140566
GeneOntologyMolecularFunction	amino acid binding	RARS1 MTR TDO2 PRODH	1.40e-04	73	72	4	GO:0016597
GeneOntologyMolecularFunction	chromatin-protein adaptor activity	BRDT MSL3 ZZEF1	4.34e-04	41	72	3	GO:0140463
GeneOntologyMolecularFunction	DNA endonuclease activity	RBBP8 XRCC4 POLQ	5.35e-04	44	72	3	GO:0004520
GeneOntologyBiologicalProcess	signal release from synapse	ASIC1 SV2B SV2A SV2C UNC13C UNC13A	7.18e-05	195	74	6	GO:0099643
GeneOntologyBiologicalProcess	neurotransmitter secretion	ASIC1 SV2B SV2A SV2C UNC13C UNC13A	7.18e-05	195	74	6	GO:0007269
GeneOntologyBiologicalProcess	dense core granule priming	UNC13C UNC13A	7.58e-05	4	74	2	GO:0061789
GeneOntologyBiologicalProcess	synaptic vesicle exocytosis	SV2B SV2A SV2C UNC13C UNC13A	8.70e-05	125	74	5	GO:0016079
GeneOntologyCellularComponent	DNA repair complex	BRCA2 XRCC4 PALB2	7.46e-05	23	75	3	GO:1990391
GeneOntologyCellularComponent	exocytic vesicle membrane	SV2B SV2A SV2C UNC13C UNC13A	4.63e-04	179	75	5	GO:0099501
GeneOntologyCellularComponent	synaptic vesicle membrane	SV2B SV2A SV2C UNC13C UNC13A	4.63e-04	179	75	5	GO:0030672
GeneOntologyCellularComponent	neuromuscular junction	SV2A UNC13C PDZRN3 UNC13A	7.08e-04	112	75	4	GO:0031594
Domain	SV2	SV2B SV2A SV2C	5.97e-08	3	74	3	IPR022308
Domain	Pentapeptide_4	SV2B SV2A SV2C	5.97e-08	3	74	3	PF13599
Domain	5peptide_repeat	SV2B SV2A SV2C	2.38e-07	4	74	3	IPR001646
Domain	Unc-13	UNC13C UNC13A	4.63e-05	3	74	2	IPR027080
Domain	Ephrin_rec_like	EPHB3 EPHB4 ELAPOR1	1.29e-04	25	74	3	SM01411
Domain	Tyr-kin_ephrin_A/B_rcpt-like	EPHB3 EPHB4 ELAPOR1	1.29e-04	25	74	3	IPR011641
Domain	Munc13_dom-2	UNC13C UNC13A	1.54e-04	5	74	2	IPR014772
Domain	Membr_traf_MHD	UNC13C UNC13A	1.54e-04	5	74	2	PF10540
Domain	MHD2	UNC13C UNC13A	1.54e-04	5	74	2	PS51259
Domain	Munc13_subgr_dom-2	UNC13C UNC13A	1.54e-04	5	74	2	IPR019558
Domain	DUF1041	UNC13C UNC13A	1.54e-04	5	74	2	SM01145
Domain	-	EPHB3 EPHB4 ZZEF1 SUCO	2.01e-04	73	74	4	2.60.120.260
Domain	Sugar_transporter_CS	SV2B SV2A SV2C	2.73e-04	32	74	3	IPR005829
Domain	DUF1041	UNC13C UNC13A	3.21e-04	7	74	2	PF06292
Domain	Munc13_1	UNC13C UNC13A	3.21e-04	7	74	2	IPR014770
Domain	CAPS_dom	UNC13C UNC13A	3.21e-04	7	74	2	IPR010439
Domain	MHD1	UNC13C UNC13A	3.21e-04	7	74	2	PS51258
Domain	MFS_sugar_transport-like	SV2B SV2A SV2C	3.88e-04	36	74	3	IPR005828
Domain	Sugar_tr	SV2B SV2A SV2C	3.88e-04	36	74	3	PF00083
Domain	Galactose-bd-like	EPHB3 EPHB4 ZZEF1 SUCO	5.29e-04	94	74	4	IPR008979
Domain	Ephrin_rec_like	EPHB3 EPHB4	8.32e-04	11	74	2	PF07699
Domain	RECEPTOR_TYR_KIN_V_2	EPHB3 EPHB4	1.37e-03	14	74	2	PS00791
Domain	RECEPTOR_TYR_KIN_V_1	EPHB3 EPHB4	1.37e-03	14	74	2	PS00790
Domain	Eph_TM	EPHB3 EPHB4	1.37e-03	14	74	2	IPR027936
Domain	Tyr_kinase_rcpt_V_CS	EPHB3 EPHB4	1.37e-03	14	74	2	IPR001426
Domain	EPH_lbd	EPHB3 EPHB4	1.37e-03	14	74	2	SM00615
Domain	Ephrin_lbd	EPHB3 EPHB4	1.37e-03	14	74	2	PF01404
Domain	EphA2_TM	EPHB3 EPHB4	1.37e-03	14	74	2	PF14575
Domain	Tyr_kinase_ephrin_rcpt	EPHB3 EPHB4	1.37e-03	14	74	2	IPR016257
Domain	Ephrin_rcpt_lig-bd_dom	EPHB3 EPHB4	1.37e-03	14	74	2	IPR001090
Domain	EPH_LBD	EPHB3 EPHB4	1.37e-03	14	74	2	PS51550
Domain	C1_1	DGKG UNC13C UNC13A	1.50e-03	57	74	3	PF00130
Domain	VWD	MUC5B VWDE	1.79e-03	16	74	2	SM00216
Domain	VWF_type-D	MUC5B VWDE	1.79e-03	16	74	2	IPR001846
Domain	VWFD	MUC5B VWDE	1.79e-03	16	74	2	PS51233
Domain	VWD	MUC5B VWDE	1.79e-03	16	74	2	PF00094
Domain	ZF_DAG_PE_1	DGKG UNC13C UNC13A	2.09e-03	64	74	3	PS00479
Domain	ZF_DAG_PE_2	DGKG UNC13C UNC13A	2.09e-03	64	74	3	PS50081
Domain	C1	DGKG UNC13C UNC13A	2.19e-03	65	74	3	SM00109
Domain	CTCK_1	SLIT2 MUC5B	2.27e-03	18	74	2	PS01185
Domain	PE/DAG-bd	DGKG UNC13C UNC13A	2.28e-03	66	74	3	IPR002219
Domain	CT	SLIT2 MUC5B	3.40e-03	22	74	2	SM00041
Domain	MFS_1	SV2B SV2A SV2C	3.54e-03	77	74	3	PF07690
Domain	MFS	SV2B SV2A SV2C	3.54e-03	77	74	3	IPR011701
Pathway	REACTOME_TOXICITY_OF_BOTULINUM_TOXIN_TYPE_D_BOTD	SV2B SV2A SV2C	4.71e-07	5	52	3	M27427
Pathway	REACTOME_NEUROTOXICITY_OF_CLOSTRIDIUM_TOXINS	SV2B SV2A SV2C	5.58e-06	10	52	3	M27018
Pathway	REACTOME_HDR_THROUGH_MMEJ_ALT_NHEJ	BRCA2 RBBP8 POLQ	1.02e-05	12	52	3	M27569
Pathway	REACTOME_HDR_THROUGH_MMEJ_ALT_NHEJ	BRCA2 RBBP8 POLQ	1.02e-05	12	52	3	MM15282
Pathway	REACTOME_HOMOLOGOUS_DNA_PAIRING_AND_STRAND_EXCHANGE	BRCA2 RBBP8 PALB2	1.16e-04	26	52	3	MM15297
Pathway	REACTOME_RESOLUTION_OF_D_LOOP_STRUCTURES_THROUGH_SYNTHESIS_DEPENDENT_STRAND_ANNEALING_SDSA	BRCA2 RBBP8 PALB2	1.30e-04	27	52	3	M27586
Pathway	REACTOME_UPTAKE_AND_ACTIONS_OF_BACTERIAL_TOXINS	SV2B SV2A SV2C	1.62e-04	29	52	3	M27431
Pathway	REACTOME_DNA_DOUBLE_STRAND_BREAK_REPAIR	BRCA2 RBBP8 XRCC4 POLQ PALB2	1.95e-04	146	52	5	MM15292
Pathway	REACTOME_RESOLUTION_OF_D_LOOP_STRUCTURES	BRCA2 RBBP8 PALB2	2.85e-04	35	52	3	MM15293
Pathway	REACTOME_RESOLUTION_OF_D_LOOP_STRUCTURES	BRCA2 RBBP8 PALB2	3.37e-04	37	52	3	M27583
Pathway	REACTOME_DNA_DOUBLE_STRAND_BREAK_REPAIR	BRCA2 RBBP8 XRCC4 POLQ PALB2	3.95e-04	170	52	5	M27582
Pathway	REACTOME_HOMOLOGOUS_DNA_PAIRING_AND_STRAND_EXCHANGE	BRCA2 RBBP8 PALB2	5.26e-04	43	52	3	M27588
Pathway	REACTOME_DNA_REPAIR	BRCA2 RBBP8 XRCC4 POLQ COPS6 PALB2	8.04e-04	301	52	6	MM15433
Pathway	REACTOME_HOMOLOGY_DIRECTED_REPAIR	BRCA2 RBBP8 POLQ PALB2	8.69e-04	116	52	4	MM15294
Pathway	REACTOME_DISEASES_OF_DNA_REPAIR	BRCA2 RBBP8 PALB2	8.70e-04	51	52	3	M29854
Pathway	KEGG_AXON_GUIDANCE	EPHB3 EPHB4 SLIT2 NFATC4	1.29e-03	129	52	4	M5539
Pathway	REACTOME_HDR_THROUGH_HOMOLOGOUS_RECOMBINATION_HRR	BRCA2 RBBP8 PALB2	1.33e-03	59	52	3	MM15283
Pathway	REACTOME_DNA_REPAIR	BRCA2 RBBP8 XRCC4 POLQ COPS6 PALB2	1.33e-03	332	52	6	M15434
Pathway	REACTOME_N_GLYCAN_ANTENNAE_ELONGATION	MGAT4C B4GALT1	1.36e-03	15	52	2	M966
Pathway	REACTOME_N_GLYCAN_ANTENNAE_ELONGATION	MGAT4C B4GALT1	1.36e-03	15	52	2	MM15700
Pathway	KEGG_MEDICUS_REFERENCE_HOMOLOGOUS_RECOMBINATION_IN_ICLR	BRCA2 PALB2	1.55e-03	16	52	2	M47855
Pathway	REACTOME_HOMOLOGY_DIRECTED_REPAIR	BRCA2 RBBP8 POLQ PALB2	1.74e-03	140	52	4	M27584
Pathway	KEGG_RENIN_ANGIOTENSIN_SYSTEM	NLN REN	1.75e-03	17	52	2	M17636
Pathway	REACTOME_EPHRIN_SIGNALING	EPHB3 EPHB4	1.97e-03	18	52	2	MM15024
Pathway	WP_MALE_INFERTILITY	BRCA2 BRDT MTR XRCC4	1.98e-03	145	52	4	M39856
Pathway	REACTOME_HDR_THROUGH_HOMOLOGOUS_RECOMBINATION_HRR	BRCA2 RBBP8 PALB2	2.18e-03	70	52	3	M27570
Pathway	REACTOME_EPHRIN_SIGNALING	EPHB3 EPHB4	2.19e-03	19	52	2	M27310
Pathway	REACTOME_BACTERIAL_INFECTION_PATHWAYS	SV2B SV2A SV2C	2.27e-03	71	52	3	M48033
Pubmed	The synaptic vesicle cycle.	SV2B SV2A SV2C UNC13C UNC13A	6.62e-09	31	75	5	15217342
Pubmed	Expression pattern of synaptic vesicle protein 2 (SV2) isoforms in patients with temporal lobe epilepsy and hippocampal sclerosis.	SV2B SV2A SV2C	9.63e-09	3	75	3	23617838
Pubmed	No major role of common SV2A variation for predisposition or levetiracetam response in epilepsy.	SV2B SV2A SV2C	9.63e-09	3	75	3	18977120
Pubmed	SV2 is the protein receptor for botulinum neurotoxin A.	SV2B SV2A SV2C	9.63e-09	3	75	3	16543415
Pubmed	Differential distribution and developmental expression of synaptic vesicle protein 2 isoforms in the mouse retina.	SV2B SV2A SV2C	9.63e-09	3	75	3	12687700
Pubmed	Expression of SV2 isoforms during rodent brain development.	SV2B SV2A SV2C	9.63e-09	3	75	3	23937191
Pubmed	SV2 modulates the size of the readily releasable pool of secretory vesicles.	SV2B SV2A SV2C	9.63e-09	3	75	3	11483953
Pubmed	Differentiation of two human neuroblastoma cell lines alters SV2 expression patterns.	SV2B SV2A SV2C	9.63e-09	3	75	3	33588752
Pubmed	Requirement for Slit-1 and Robo-2 in zonal segregation of olfactory sensory neuron axons in the main olfactory bulb.	SLIT2 SV2B SV2A SV2C	3.56e-08	16	75	4	17715346
Pubmed	SV2B regulates synaptotagmin 1 by direct interaction.	SV2B SV2A SV2C	1.92e-07	6	75	3	15466855
Pubmed	Pulmonary neuroendocrine cells, airway innervation, and smooth muscle are altered in Cftr null mice.	SV2B SV2A SV2C	1.92e-07	6	75	3	16614351
Pubmed	PALB2 is an integral component of the BRCA complex required for homologous recombination repair.	BRCA2 RBBP8 PALB2	1.92e-07	6	75	3	19369211
Pubmed	Synaptobrevin is essential for secretion but not for the development of synaptic processes.	SV2B SV2A SV2C	5.35e-07	8	75	3	8738414
Pubmed	RNF168-mediated localization of BARD1 recruits the BRCA1-PALB2 complex to DNA damage.	BRCA2 RBBP8 PALB2	5.35e-07	8	75	3	34408138
Pubmed	Functional and mutational landscapes of BRCA1 for homology-directed repair and therapy resistance.	BRCA2 RBBP8 PALB2	8.02e-07	9	75	3	28398198
Pubmed	Stabilization of mutant BRCA1 protein confers PARP inhibitor and platinum resistance.	BRCA2 RBBP8 PALB2	8.02e-07	9	75	3	24085845
Pubmed	Conserved overlapping gene arrangement, restricted expression, and biochemical activities of DNA polymerase ν (POLN).	BRCA2 RBBP8 PALB2	8.02e-07	9	75	3	26269593
Pubmed	Expression and localisation of dynamin and syntaxin during neural development and neuromuscular synapse formation.	SV2B SV2A SV2C	1.14e-06	10	75	3	10398046
Pubmed	Generation of GABAergic and dopaminergic interneurons from endogenous embryonic olfactory bulb precursor cells.	SV2B SV2A SV2C	1.14e-06	10	75	3	17038521
Pubmed	Restoration of synapse formation in Musk mutant mice expressing a Musk/Trk chimeric receptor.	SV2B SV2A SV2C	1.57e-06	11	75	3	12403715
Pubmed	Multiple roles of integrin-α3 at the neuromuscular junction.	SV2B SV2A SV2C	2.09e-06	12	75	3	28386022
Pubmed	Kirrel3 is required for the coalescence of vomeronasal sensory neuron axons into glomeruli and for male-male aggression.	SV2B SV2A SV2C	2.71e-06	13	75	3	23637329
Pubmed	Roles of neurotransmitter in synapse formation: development of neuromuscular junctions lacking choline acetyltransferase.	SV2B SV2A SV2C	3.45e-06	14	75	3	12441053
Pubmed	Calcium channels link the muscle-derived synapse organizer laminin β2 to Bassoon and CAST/Erc2 to organize presynaptic active zones.	SV2B SV2A SV2C	3.45e-06	14	75	3	21228161
Pubmed	SV2 renders primed synaptic vesicles competent for Ca2+ -induced exocytosis.	SV2B SV2A	4.59e-06	2	75	2	19176798
Pubmed	PALB2 regulates recombinational repair through chromatin association and oligomerization.	BRCA2 PALB2	4.59e-06	2	75	2	19423707
Pubmed	Synaptic vesicle protein 2 binds adenine nucleotides.	SV2B SV2A	4.59e-06	2	75	2	18524768
Pubmed	SV2 mediates entry of tetanus neurotoxin into central neurons.	SV2B SV2A	4.59e-06	2	75	2	21124874
Pubmed	Genotype-cancer association in patients with Fanconi anemia due to pathogenic variants in FANCD1 (BRCA2) or FANCN (PALB2).	BRCA2 PALB2	4.59e-06	2	75	2	34687993
Pubmed	CtIP-mediated DNA resection is dispensable for IgH class switch recombination by alternative end-joining.	RBBP8 XRCC4	4.59e-06	2	75	2	32989150
Pubmed	Fanconi anemia is associated with a defect in the BRCA2 partner PALB2.	BRCA2 PALB2	4.59e-06	2	75	2	17200672
Pubmed	Rare germline variants in PALB2 and BRCA2 in familial and sporadic chordoma.	BRCA2 PALB2	4.59e-06	2	75	2	35762214
Pubmed	A genetic screen identifies BRCA2 and PALB2 as key regulators of G2 checkpoint maintenance.	BRCA2 PALB2	4.59e-06	2	75	2	21637299
Pubmed	Cloning, characterization, and differential expression of MDK2 and MDK5, two novel receptor tyrosine kinases of the eck/eph family.	EPHB3 EPHB4	4.59e-06	2	75	2	7478528
Pubmed	Two Missense Variants Detected in Breast Cancer Probands Preventing BRCA2-PALB2 Protein Interaction.	BRCA2 PALB2	4.59e-06	2	75	2	30410870
Pubmed	Breast-cancer risk in families with mutations in PALB2.	BRCA2 PALB2	4.59e-06	2	75	2	25099575
Pubmed	SV2 regulates neurotransmitter release via multiple mechanisms.	SV2B SV2A	4.59e-06	2	75	2	20702688
Pubmed	Association analysis of PALB2 and BRCA2 in bipolar disorder and schizophrenia in a scandinavian case-control sample.	BRCA2 PALB2	4.59e-06	2	75	2	20872766
Pubmed	Plasticity of BRCA2 function in homologous recombination: genetic interactions of the PALB2 and DNA binding domains.	BRCA2 PALB2	4.59e-06	2	75	2	22194698
Pubmed	Synaptic vesicle protein 2 enhances release probability at quiescent synapses.	SV2B SV2A	4.59e-06	2	75	2	16436618
Pubmed	Fanconi anemia gene mutations are not involved in sporadic Wilms tumor.	BRCA2 PALB2	4.59e-06	2	75	2	20589654
Pubmed	Altered balance between excitatory and inhibitory inputs onto CA1 pyramidal neurons from SV2A-deficient but not SV2B-deficient mice.	SV2B SV2A	4.59e-06	2	75	2	22847229
Pubmed	Analysis of PALB2/FANCN-associated breast cancer families.	BRCA2 PALB2	4.59e-06	2	75	2	17420451
Pubmed	Glycosylated SV2A and SV2B mediate the entry of botulinum neurotoxin E into neurons.	SV2B SV2A	4.59e-06	2	75	2	18815274
Pubmed	Abnormal neurotransmission in mice lacking synaptic vesicle protein 2A (SV2A).	SV2B SV2A	4.59e-06	2	75	2	10611374
Pubmed	Structural basis for recruitment of BRCA2 by PALB2.	BRCA2 PALB2	4.59e-06	2	75	2	19609323
Pubmed	Brain contains two forms of synaptic vesicle protein 2.	SV2B SV2A	4.59e-06	2	75	2	7681585
Pubmed	Mutations in BRCA2 and PALB2 in male breast cancer cases from the United States.	BRCA2 PALB2	4.59e-06	2	75	2	20927582
Pubmed	SV2A and SV2B function as redundant Ca2+ regulators in neurotransmitter release.	SV2B SV2A	4.59e-06	2	75	2	10624962
Pubmed	The nuclear envelope protein Net39 is essential for muscle nuclear integrity and chromatin organization.	SV2B SV2A SV2C	7.68e-06	18	75	3	33514739
Pubmed	Tracheal separation is driven by NKX2-1-mediated repression of Efnb2 and regulation of endodermal cell sorting.	EPHB3 EPHB4 MUC5B	9.10e-06	19	75	3	35294885
Pubmed	Two PALB2 germline mutations found in both BRCA1+ and BRCAx familial breast cancer.	BRCA2 PALB2	1.37e-05	3	75	2	25833210
Pubmed	Interaction with PALB2 Is Essential for Maintenance of Genomic Integrity by BRCA2.	BRCA2 PALB2	1.37e-05	3	75	2	27490902
Pubmed	A Survey of BRCA1, BRCA2, and PALB2 mutations in women with breast cancer in Trinidad and Tobago.	BRCA2 PALB2	1.37e-05	3	75	2	27469594
Pubmed	Optimization of prediction methods for risk assessment of pathogenic germline variants in the Japanese population.	BRCA2 PALB2	1.37e-05	3	75	2	34036661
Pubmed	The Munc13 proteins differentially regulate readily releasable pool dynamics and calcium-dependent recovery at a central synapse.	UNC13C UNC13A	1.37e-05	3	75	2	23658173
Pubmed	The risk of breast cancer due to PALB2 gene mutations.	BRCA2 PALB2	1.37e-05	3	75	2	28791855
Pubmed	Elevated CXorf67 Expression in PFA Ependymomas Suppresses DNA Repair and Sensitizes to PARP Inhibitors.	BRCA2 PALB2	1.37e-05	3	75	2	33186520
Pubmed	Germline mutations of multiple breast cancer-related genes are differentially associated with triple-negative breast cancers and prognostic factors.	BRCA2 PALB2	1.37e-05	3	75	2	32029870
Pubmed	Breast cancer proteins PALB2 and BRCA2 stimulate polymerase η in recombination-associated DNA synthesis at blocked replication forks.	BRCA2 PALB2	1.37e-05	3	75	2	24485656
Pubmed	A Phase I/II Study of Veliparib (ABT-888) in Combination with 5-Fluorouracil and Oxaliplatin in Patients with Metastatic Pancreatic Cancer.	BRCA2 PALB2	1.37e-05	3	75	2	32669374
Pubmed	Identification and Management of Pathogenic Variants in BRCA1, BRCA2, and PALB2 in a Tumor-Only Genomic Testing Program.	BRCA2 PALB2	1.37e-05	3	75	2	35363308
Pubmed	A Hypomorphic PALB2 Allele Gives Rise to an Unusual Form of FA-N Associated with Lymphoid Tumour Development.	BRCA2 PALB2	1.37e-05	3	75	2	26990772
Pubmed	Multigene Panel Testing Detects Equal Rates of Pathogenic BRCA1/2 Mutations and has a Higher Diagnostic Yield Compared to Limited BRCA1/2 Analysis Alone in Patients at Risk for Hereditary Breast Cancer.	BRCA2 PALB2	1.37e-05	3	75	2	26219241
Pubmed	BRCA and PALB2 mutations in a cohort of male breast cancer with one bilateral case.	BRCA2 PALB2	1.37e-05	3	75	2	32058061
Pubmed	Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2.	BRCA2 PALB2	1.37e-05	3	75	2	16793542
Pubmed	Cooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombination.	BRCA2 PALB2	1.37e-05	3	75	2	20871615
Pubmed	Mutations in BRCA1, BRCA2, and PALB2, and a panel of 50 cancer-associated genes in pancreatic ductal adenocarcinoma.	BRCA2 PALB2	1.37e-05	3	75	2	29802286
Pubmed	Contribution of germline mutations in the BRCA and PALB2 genes to pancreatic cancer in Italy.	BRCA2 PALB2	1.37e-05	3	75	2	21989927
Pubmed	PALB2 links BRCA1 and BRCA2 in the DNA-damage response.	BRCA2 PALB2	1.37e-05	3	75	2	19268590
Pubmed	Compensatory functions and interdependency of the DNA-binding domain of BRCA2 with the BRCA1-PALB2-BRCA2 complex.	BRCA2 PALB2	1.37e-05	3	75	2	24285729
Pubmed	Founder BRCA1/BRCA2/PALB2 pathogenic variants in French-Canadian breast cancer cases and controls.	BRCA2 PALB2	1.37e-05	3	75	2	32300229
Pubmed	PALB2 connects BRCA1 and BRCA2 in the G2/M checkpoint response.	BRCA2 PALB2	1.37e-05	3	75	2	30337689
Pubmed	Overlapping functions of stonin 2 and SV2 in sorting of the calcium sensor synaptotagmin 1 to synaptic vesicles.	SV2B SV2A	1.37e-05	3	75	2	26015569
Pubmed	Heterogeneous Presynaptic Distribution of Munc13 Isoforms at Retinal Synapses and Identification of an Unconventional Bipolar Cell Type with Dual Expression of Munc13 Isoforms: A Study Using Munc13-EXFP Knock-in Mice.	UNC13C UNC13A	1.37e-05	3	75	2	33105896
Pubmed	Analysis of large deletions in BRCA1, BRCA2 and PALB2 genes in Finnish breast and ovarian cancer families.	BRCA2 PALB2	1.37e-05	3	75	2	18501021
Pubmed	Nonconserved Ca(2+)/calmodulin binding sites in Munc13s differentially control synaptic short-term plasticity.	UNC13C UNC13A	1.37e-05	3	75	2	22966208
Pubmed	BRCA and pancreatic cancer.	BRCA2 PALB2	1.37e-05	3	75	2	23846919
Pubmed	Low Expression of EphB2, EphB3, and EphB4 in Bladder Cancer: Novel Potential Indicators of Muscular Invasion.	EPHB3 EPHB4	1.37e-05	3	75	2	34296545
Pubmed	Aberrant morphology and residual transmitter release at the Munc13-deficient mouse neuromuscular synapse.	UNC13C UNC13A	1.37e-05	3	75	2	15988013
Pubmed	Analysis of PALB2 gene in BRCA1/BRCA2 negative Spanish hereditary breast/ovarian cancer families with pancreatic cancer cases.	BRCA2 PALB2	1.37e-05	3	75	2	23935836
Pubmed	Redundant functions of RIM1alpha and RIM2alpha in Ca(2+)-triggered neurotransmitter release.	SV2B UNC13C UNC13A	2.42e-05	26	75	3	17124501
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	ZNF711 SLIT2 BRDT SV2A NTAQ1 LTN1 MTR USP54 ZZEF1 PDZRN3 TCTN2	2.65e-05	1116	75	11	31753913
Pubmed	Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBN and Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and Neurodegeneration.	SV2B SV2A UBR3 COPS6	2.65e-05	79	75	4	27325702
Pubmed	PALB2 functionally connects the breast cancer susceptibility proteins BRCA1 and BRCA2.	BRCA2 PALB2	2.75e-05	4	75	2	19584259
Pubmed	Diverse BRCA1 and BRCA2 Reversion Mutations in Circulating Cell-Free DNA of Therapy-Resistant Breast or Ovarian Cancer.	BRCA2 PALB2	2.75e-05	4	75	2	28765325
Pubmed	Validation of a next generation sequencing assay for BRCA1, BRCA2, CHEK2 and PALB2 genetic testing.	BRCA2 PALB2	2.75e-05	4	75	2	32531196
Pubmed	Roles for APRIN (PDS5B) in homologous recombination and in ovarian cancer prediction.	BRCA2 PALB2	2.75e-05	4	75	2	27924011
Pubmed	Tissue-specific effects of valproic acid on DNA repair genes and apoptosis in postimplantation mouse embryos.	BRCA2 XRCC4	2.75e-05	4	75	2	24913804
Pubmed	BRCA1, BRCA2 and PALB2 mutations and CHEK2 c.1100delC in different South African ethnic groups diagnosed with premenopausal and/or triple negative breast cancer.	BRCA2 PALB2	2.75e-05	4	75	2	26577449
Pubmed	Loss of the SV2-like protein SVOP produces no apparent deficits in laboratory mice.	SV2B SV2A	2.75e-05	4	75	2	23894296
Pubmed	BRCA1, BRCA2, PALB2, and CDKN2A mutations in familial pancreatic cancer: a PACGENE study.	BRCA2 PALB2	2.75e-05	4	75	2	25356972
Pubmed	A glutaminase (gis) gene maps to mouse chromosome 1, rat chromosome 9, and human chromosome 2.	C4BPA REN	2.75e-05	4	75	2	2571577
Pubmed	Cotrafficking of SV2 and synaptotagmin at the synapse.	SV2B SV2A	2.75e-05	4	75	2	20410110
Pubmed	Defects of FA/BRCA pathway in lymphoma cell lines.	BRCA2 PALB2	2.75e-05	4	75	2	19011769
Pubmed	Molecular cloning and chromosomal localization of the mouse decay-accelerating factor genes. Duplicated genes encode glycosylphosphatidylinositol-anchored and transmembrane forms.	C4BPA REN	2.75e-05	4	75	2	7545711
Pubmed	Spatial distribution and developmental appearance of postjunctional P2X1 receptors on smooth muscle cells of the mouse vas deferens.	SV2B SV2A	2.75e-05	4	75	2	11668586
Pubmed	Mutation analysis of BRCA1, BRCA2, PALB2 and BRD7 in a hospital-based series of German patients with triple-negative breast cancer.	BRCA2 PALB2	2.75e-05	4	75	2	23110154
Pubmed	Phosphorylated RPA recruits PALB2 to stalled DNA replication forks to facilitate fork recovery.	BRCA2 PALB2	2.75e-05	4	75	2	25113031
Pubmed	Compromised BRCA1-PALB2 interaction is associated with breast cancer risk.	BRCA2 PALB2	2.75e-05	4	75	2	28319063
Cytoband	4p15.2	SLIT2 LGI2	9.68e-04	28	75	2	4p15.2
Cytoband	Ensembl 112 genes in cytogenetic band chr5q13	ENC1 NAIP SV2C	2.02e-03	152	75	3	chr5q13
Cytoband	1q32	C4BPA REN	2.95e-03	49	75	2	1q32
GeneFamily	UNC13 homologs	UNC13C UNC13A	4.13e-05	4	48	2	836
GeneFamily	Fibronectin type III domain containing\|Sterile alpha motif domain containing\|EPH receptors	EPHB3 EPHB4	6.15e-04	14	48	2	1095
GeneFamily	Ring finger proteins\|Fanconi anemia complementation groups\|Protein phosphatase 1 regulatory subunits\|BRCA1 A complex\|BRCA1 B complex\|BRCA1 C complex	BRCA2 PALB2	1.27e-03	20	48	2	548
Coexpression	GSE26669_CD4_VS_CD8_TCELL_IN_MLR_DN	SLIT2 DPY19L1 SV2A SV2C PSPH ZZEF1 B4GALT1	1.53e-06	199	74	7	M4670
Coexpression	MANNO_MIDBRAIN_NEUROTYPES_HDA1	NLN SPINT2 LGI2 SV2A RALGPS1 ENC1 SV2C TMEM151A PALB2 UNC13A	5.57e-06	584	74	10	M39068
Coexpression	MANNO_MIDBRAIN_NEUROTYPES_HNBGABA	NLN SPINT2 LGI2 SV2B SV2A RALGPS1 ENC1 SV2C PALB2 UNC13A	2.76e-05	703	74	10	M39070
Coexpression	DODD_NASOPHARYNGEAL_CARCINOMA_UP	EPHB4 NLN BRCA2 DPY19L1 RBBP8 MTR TMPO TDO2 PSPH XRCC4 POLQ AJUBA PALB2 ZNF121	3.41e-05	1407	74	14	M14427
ToppCell	E12.5-Mesenchymal-mesenchymal_fibroblast-mesothelial_cell_of_visceral_pleura\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	HHIP ASIC1 SV2A RDH10 REN TDO2 TMEM151A PLCE1	9.77e-10	186	75	8	1587667e5084ac43505d027af925ba711e228150
ToppCell	E18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ASIC1 SV2A UNC13C REN TDO2 TMEM151A PLCE1	2.13e-08	178	75	7	bcbdd45a2307f8aea14122fa0144b96b1f6eec48
ToppCell	E18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ASIC1 SV2A UNC13C REN TDO2 TMEM151A PLCE1	2.13e-08	178	75	7	c413861148129be1ee94f2ceb5999840217eebe5
ToppCell	E15.5-Mesenchymal-mesenchymal_fibroblast-mesothelial_cell_of_visceral_pleura\|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	HHIP RDH10 UNC13C REN TDO2 TMEM151A PLCE1	2.58e-08	183	75	7	274f274cf60daa30d6a4cd603a3af7823bfb8016
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_adventitial_fibro_(9)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	SLIT2 UNC13C TDO2 GPC6 MGAT4C PDZRN3 PLCE1	3.85e-08	194	75	7	5f5f0cdeacd5e1b28717d78dabdb9eb95f661e36
ToppCell	P03-Mesenchymal-mesenchymal_fibroblast-mesothelial_cell_of_visceral_pleura\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ASIC1 UNC13C REN TDO2 TMEM151A PLCE1	6.04e-07	180	75	6	2ccc77d769d3ffd77ab3af45e4f192785b6db79c
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LOXHD1 PKHD1 UNC13C MUC5B ODAD2 PLCE1	6.87e-07	184	75	6	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LOXHD1 PKHD1 UNC13C MUC5B ODAD2 PLCE1	6.87e-07	184	75	6	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LOXHD1 PKHD1 UNC13C MUC5B ODAD2 PLCE1	6.87e-07	184	75	6	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	Fetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	SV2B ELAPOR1 SV2C MGAT4C VWDE UNC13A	7.32e-07	186	75	6	b45cce768e4bf91da194fd9660cab7520dfb15ac
ToppCell	PND28-Epithelial-Epithelial_Airway-Neurosecretory-Secretory-Secretory_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SPINT2 HP ELAPOR1 PKHD1 MUC5B	4.67e-06	145	75	5	9b69bfdbf91ef197b4c483617aa67498d9d2cd79
ToppCell	PND28-Epithelial-Epithelial_Airway-Neurosecretory-Secretory\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SPINT2 HP ELAPOR1 PKHD1 MUC5B	4.67e-06	145	75	5	31af9fce1dcd7e8ae1604476598e099232017ee9
ToppCell	PND28-Epithelial-Epithelial_Airway-Neurosecretory\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SPINT2 HP ELAPOR1 PKHD1 MUC5B	4.67e-06	145	75	5	76f0cde9acdc3ad5948c007dccf312665972c9e6
ToppCell	10x5'-GI_small-bowel-Lymphocytic_Invariant-Inducer-like-MAIT\|GI_small-bowel / Manually curated celltypes from each tissue	KIAA1210 ENC1 DGKG C4BPA PDZRN3	4.83e-06	146	75	5	1cb2e157222631e8915d89b255a843d16d7d99cc
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	EXOC3L4 ELAPOR1 ODAD2 MGAT4C PLCE1	5.33e-06	149	75	5	cc6224c6b79f43b97adc1ce48ca4906bff2ad318
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	EXOC3L4 ELAPOR1 ODAD2 MGAT4C PLCE1	5.33e-06	149	75	5	24a7538b54b2a5291503c7493fefed4e45e8d710
ToppCell	PND01-Epithelial-Epithelial_Airway-Neurosecretory-Secretory\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SPINT2 HP SV2B ELAPOR1 SH3BGRL2	7.54e-06	160	75	5	b4844a8c7755a2b2868019791d8d224154973445
ToppCell	PND01-Epithelial-Epithelial_Airway-Neurosecretory-Secretory-Secretory_mature\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SPINT2 HP SV2B ELAPOR1 SH3BGRL2	7.54e-06	160	75	5	01ae730e9d0d05f3277f862f0c09bafb32b89db5
ToppCell	PND01-Epithelial-Epithelial_Airway-Neurosecretory\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SPINT2 HP SV2B ELAPOR1 SH3BGRL2	7.54e-06	160	75	5	6de9e7be1d860d82d503bfbc779e72f072a6efc3
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal--glomerular_mesenchymal_cell-Renin-positive_Juxtaglomerular_Granular_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LGI2 SV2A DGKG REN UNC13A	8.76e-06	165	75	5	9de841c1c95967c562720feba930246debc626fd
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LGI2 SV2A DGKG REN UNC13A	8.76e-06	165	75	5	a612a7d3a5415ecacc3df8fbff0ce498f982aad0
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal--glomerular_mesenchymal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LGI2 SV2A DGKG REN UNC13A	8.76e-06	165	75	5	cdc94a640ec01c6892521bcd6f0ee0a66ff23866
ToppCell	367C-Myeloid-Macrophage-FABP4+_Macrophage_3\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	HHIP NFATC4 ASIC1 PDZRN3 PRODH	9.02e-06	166	75	5	f416d8a322f086c769659a9fab6b460a2d546ab1
ToppCell	Children_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SV2B SV2A ELAPOR1 VWDE UNC13A	9.28e-06	167	75	5	c87ebfa8c3284ad33579190e148c95bcaf670d17
ToppCell	Children_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SV2B ELAPOR1 MGAT4C VWDE UNC13A	9.83e-06	169	75	5	b6b5bb6408c1305a00719e1b88a5e1202081faf3
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal--glomerular_mesenchymal_cell-Renin-positive_Juxtaglomerular_Granular_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	LGI2 NFATC4 DGKG REN UNC13A	1.01e-05	170	75	5	99dd734c0972a40d5381e8e2d96bdaa31f6d06e6
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal--glomerular_mesenchymal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	LGI2 NFATC4 DGKG REN UNC13A	1.01e-05	170	75	5	3a14eeae221b8bb0bd0dadcb8e7a603431240a1e
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	LGI2 NFATC4 DGKG REN UNC13A	1.01e-05	170	75	5	cdb6fad277f284c3fd5a6f45672a8edc24715882
ToppCell	5'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SPINT2 NFATC4 ELAPOR1 AJUBA CALHM4	1.07e-05	172	75	5	bd01b39a5699824ab14827cc9dc98e547d65b160
ToppCell	primary_auditory_cortex_(A1C)\|World / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLIT2 NUP210L GPC6 PDZRN3 TCTN2	1.07e-05	172	75	5	20ea9db009370aa6235365ce93e153eb5b28db94
ToppCell	PND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HHIP UNC13C TDO2 TMEM151A PLCE1	1.10e-05	173	75	5	30d67738633493d47f06ae452424382f069b6c0a
ToppCell	5'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SPINT2 NFATC4 ELAPOR1 AJUBA CALHM4	1.13e-05	174	75	5	911eac6f6ec1e5e85348a7fe774243498388a810
ToppCell	PND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HHIP UNC13C TDO2 TMEM151A PLCE1	1.13e-05	174	75	5	a9c6edf5c3fc119c24425f921c5566a8356c30fe
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DPY19L1 SV2B UNC13C TDO2 ODAD2	1.16e-05	175	75	5	06af6629766e2054e6995e8cdb3907658fec49d3
ToppCell	Thalamus-Neuronal-Excitatory\|Thalamus / BrainAtlas - Mouse McCarroll V32	SV2B ELAPOR1 MGAT4C UNC13A SH3BGRL2	1.20e-05	176	75	5	d2bbf13d21fb7582d7e5f90cd61a4ebe1cfccd66
ToppCell	NS-critical-d_16-33-Epithelial-FOXN4+\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	EPHB4 USP13 BRCA2 DPY19L1 PLCE1	1.20e-05	176	75	5	7cf1a06ceee1ec06532f44c729c31b4d58e5ea49
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_3\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLIT2 SV2B ENC1 SV2C GPC6	1.26e-05	178	75	5	ccea3c8908d72f5fecd151a133048c8e9758304c
ToppCell	COVID-19-kidney-vSMC/Pericyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	LGI2 DGKG REN GPC6 PLCE1	1.30e-05	179	75	5	111b1084f73306bdeffaaf240e7dbb4f5bf33de1
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_RPL31P31\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DPY19L1 SV2B UNC13C ODAD2 GPC6	1.30e-05	179	75	5	b35a7f8115c997c390201da01d7cb10b10769aec
ToppCell	Epithelial-lung_neuroendocrine_cell_(PNEC)\|World / Lineage, Cell type, age group and donor	SV2B ELAPOR1 MGAT4C VWDE UNC13A	1.41e-05	182	75	5	57bf4ffb304324e2e392e196336a530d9f78fe0d
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_2-AT2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HHIP SPINT2 C4BPA USP54 GPC6	1.41e-05	182	75	5	1e2149b222a3e9f64841aed45288a6f29394e7b0
ToppCell	LPS_only-Epithelial_alveolar-AT_2-AT2\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HHIP SPINT2 C4BPA USP54 GPC6	1.41e-05	182	75	5	d1a1feef318062f25493355d7beee8e5fb0e4206
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HHIP TGDS C4BPA USP54 GPC6	1.41e-05	182	75	5	17ed11a7ea366dd3106400511d5e628d3f1a9c3e
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2-AT2\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HHIP SPINT2 TGDS C4BPA USP54	1.44e-05	183	75	5	5f2db95d44b7de68779de098892892af540fd431
ToppCell	E17.5-Mesenchymal-mesenchymal_fibroblast-mesothelial_cell_of_visceral_pleura\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	HHIP ASIC1 REN TDO2 TMEM151A	1.48e-05	184	75	5	607b55022de21ddb6a2d75e085df76df7abf6624
ToppCell	LPS_only-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SLIT2 LGI2 DGKG GPC6 PLCE1	1.69e-05	189	75	5	975e7aa3b862a8b07c2ab8426a14f5cc54998aca
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	SLIT2 UNC13C TDO2 GPC6 PDZRN3	1.69e-05	189	75	5	203c80030df08ae112f9ae4043709f455d87ce89
ToppCell	NS-critical-d_07-13-Epithelial-FOXN4+\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	EPHB4 USP13 BRCA2 DPY19L1 PLCE1	1.73e-05	190	75	5	7be0f2ff86ca8500a43e0d44e5e292530f9ba0bb
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SLIT2 LGI2 DGKG PDZRN3 PLCE1	1.73e-05	190	75	5	73d94fbae92029745989a8712eed8b99fd84c193
ToppCell	PSB-critical-LOC-Epithelial-Ionocyte\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	KIAA1210 ENC1 UNC13C GPC6 PDZRN3	1.77e-05	191	75	5	8f4637e801554e2343b974fe7794f01dd2151418
ToppCell	droplet-Lung-18m-Mesenchymal-myofibroblast\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	HHIP TDO2 GPC6 AJUBA PDZRN3	1.82e-05	192	75	5	2cc712186e37fb21a964c032765c36a8b4a852cf
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_myocytic-mes_proliferating_SM_(20)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	KIAA1210 HHIP BRCA2 ENC1 POLQ	1.87e-05	193	75	5	bbdfda6665941cfa1965418bb91ef9ff43b1326f
ToppCell	PCW_13-14-Epithelial-Epithelial_neuroendo\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	SV2B ELAPOR1 SV2C VWDE UNC13A	1.87e-05	193	75	5	8603d1a38955ad2529d04e4704467c73ea5bfbda
ToppCell	Parenchymal-10x5prime-Epithelial-Epi_alveolar-Dividing_AT2\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	NFATC4 C4BPA USP54 VWDE PRODH	1.87e-05	193	75	5	44839a606ae2f8e37421bda46d588189e1c943d2
ToppCell	PSB-critical-LOC-Epithelial-FOXN4+\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	EPHB4 USP13 BRCA2 DPY19L1 PLCE1	1.87e-05	193	75	5	b7d9c5bed524423e92f01496a9f8fad11b33a3f7
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	SLIT2 UNC13C TDO2 GPC6 PDZRN3	1.91e-05	194	75	5	011e14d9ed1393275f892060e7708ffadcd0767f
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	SLIT2 LGI2 UNC13C PDZRN3 PLCE1	1.91e-05	194	75	5	35f132cc38ac133be01834ed0946188aa0757eb4
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	SLIT2 UNC13C GPC6 MGAT4C PDZRN3	1.91e-05	194	75	5	a3e5a15cf6c1361207f661ee15eb634f77daf1cb
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	RBBP8 RALGPS1 PKHD1 MTR DNAH14	1.96e-05	195	75	5	6477e6e7be5bd8eb99119a12ae16334ccddecd43
ToppCell	PCW_13-14-Epithelial-Epithelial_neuroendo-epi_neuroendocrine1[NE1]_(11)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	SV2B ELAPOR1 SV2C TMEM151A UNC13A	1.96e-05	195	75	5	5f33ece997f074598b4201ff74f592ee07c86a06
ToppCell	COVID-19-lung-Proliferative_fibroblast\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SLIT2 BRCA2 TDO2 POLQ GPC6	2.01e-05	196	75	5	ca91d5e325875e7444809b80fcbd491d8899ea36
ToppCell	facs-Lung-nan\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HHIP TM9SF2 GPC6 PDZRN3 PLCE1	2.01e-05	196	75	5	b05f77f3990b662682ffeaf0e4c2fb190e0a6e65
ToppCell	facs-Lung-nan-3m\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HHIP TM9SF2 GPC6 PDZRN3 PLCE1	2.01e-05	196	75	5	787c6cd92035e0b1108c2c086c42a229016e476b
ToppCell	LPS_only-Endothelial-Endothelial-FOXM1\|LPS_only / Treatment groups by lineage, cell group, cell type	USP13 BRCA2 MTR TMPO POLQ	2.06e-05	197	75	5	038fd92750257d43d5e980fd06d77742b543f11a
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	SLIT2 UNC13C TDO2 GPC6 PDZRN3	2.06e-05	197	75	5	11a4c417f035e554431a8f03be13b5eefa3530c0
ToppCell	IPF-Stromal-Myofibroblast\|Stromal / Disease state, Lineage and Cell class	SLIT2 ENC1 TDO2 PDZRN3 DNAH14	2.06e-05	197	75	5	f304d42fc4936fe20996e07c8dccc698a6e5e5ef
ToppCell	facs-Tongue-nan-3m-Epithelial-basal_cell_of_epidermis\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TM9SF2 DSG3 RBBP8 TMPO AJUBA	2.11e-05	198	75	5	22559b161e67b49fe8028bfaf861e069063599f5
ToppCell	Neuronal-Excitatory-eA(LAMP5_LINC00507)-GLP2R--\|Neuronal / cells hierarchy compared to all cells using T-Statistic	DSG3 ENC1 DGKG SV2C MGAT4C	2.21e-05	200	75	5	dc8702e3cb4ac8c1a9849fc8abf8777f12d55b0b
ToppCell	Tracheal-10x5prime-Epithelial-Epi_submucosal-gland-SMG_Serous\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	SPINT2 HP ELAPOR1 C4BPA SH3BGRL2	2.21e-05	200	75	5	e9908b6cba21a59023cf8d0f98fbd1d1f7de6b44
ToppCell	Neuronal-Excitatory-eA(LAMP5_LINC00507)-GLP2R---L2-4\|Neuronal / cells hierarchy compared to all cells using T-Statistic	DSG3 ENC1 DGKG SV2C MGAT4C	2.21e-05	200	75	5	d92d51021ab6d78e9c8f89f7c150181004dcbcbd
ToppCell	Neuronal-Excitatory-eA(LAMP5_LINC00507)-GLP2R-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	DSG3 ENC1 DGKG SV2C MGAT4C	2.21e-05	200	75	5	cbbb9044283ff9ab63bbfc24d7a9f006b1372705
ToppCell	Tracheal-10x3prime_v2-Epithelial-Epi_submucosal-gland-SMG_Serous\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	EPHB3 HP ELAPOR1 SV2C USP54	2.21e-05	200	75	5	61bae10c8b12196d9cee766897971b81cb897191
ToppCell	critical-Epithelial-FOXN4+\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	USP13 BRCA2 DPY19L1 TMPO PLCE1	2.21e-05	200	75	5	f39db4250ce220a3eb58edee3f7fc3671701d46f
ToppCell	Tracheal-10x5prime-Epithelial-Epi_submucosal-gland\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	SPINT2 ELAPOR1 MUC5B C4BPA SH3BGRL2	2.21e-05	200	75	5	a3e044468de437948b63c517e0a4773cc247c906
ToppCell	Neuronal-Excitatory-eA(LAMP5_LINC00507)-GLP2R\|Neuronal / cells hierarchy compared to all cells using T-Statistic	DSG3 ENC1 DGKG SV2C MGAT4C	2.21e-05	200	75	5	a3e36bbeed19431d07bc205f14f4e0f12bd8f730
ToppCell	LPS-IL1RA-Epithelial_alveolar-Mes-Like\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HHIP BRCA2 REN GPC6	2.78e-05	103	75	4	c11bb0238e81a42dad5d7687c9d22474129d803d
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Outer_Medullary_Collecting_Duct_Intercalated_Cell_Type_A\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLIT2 KIAA1210 LOXHD1 SV2B	7.32e-05	132	75	4	7d6cd16ca1d83d9a618ef5b7fb300c1509eeb129
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Granulocytic-Neutrophil-Neu_c2-CXCR4(low)\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	HHIP DPY19L1 SH3BGRL2 TCTN2	1.03e-04	144	75	4	3d880c140db4a0e7602bfddcb73a42a68c2848d5
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D175\|Adult / Lineage, Cell type, age group and donor	UNC13C C4BPA UNC13A DNAH14	1.20e-04	150	75	4	b0b6ba3686d3eb8a9b249d30be14111de3b893be
ToppCell	COVID-19-kidney-Technical/muscle_(Imm)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	NUP210L UNC13C MGAT4C UNC13A	1.20e-04	150	75	4	0205318a870e091add66ee4305747dda9f51510d
ToppCell	Fetal_29-31_weeks-Mesenchymal-chondrocyte-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	SLIT2 LGI2 ENC1 PDZRN3	1.23e-04	151	75	4	32d35906f4b2bd46b173e87f2dec972eb5da87b3
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DGKG REN GPC6 PLCE1	1.26e-04	152	75	4	bd1f36b436d8ab7dd8420f595b97d851eab31a38
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DGKG REN GPC6 PLCE1	1.26e-04	152	75	4	ee329249a034a969a16b26a224aa04249d67382d
ToppCell	facs-Trachea-nan-3m-Myeloid-lymphocyte_of_B_lineage\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DGKG TDO2 ODAD2 POLQ	1.43e-04	157	75	4	0fecc14959c4c9efc19d5c06475a890e0a30f148
ToppCell	Children_(3_yrs)-Mesenchymal-vascular_smooth_muscle_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	LGI2 SV2A DGKG PDZRN3	1.47e-04	158	75	4	84c0a215dabf697ada036c2b9592d0c61b5077de
ToppCell	Fetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	SV2B ELAPOR1 SV2C UNC13A	1.50e-04	159	75	4	7747cef94c55144fddcd024a7495318357f1351b
ToppCell	3'-Child09-12-SmallIntestine-Epithelial-mature_enterocytic-Paneth\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	EPHB3 ELAPOR1 SV2C MUC5B	1.54e-04	160	75	4	6005948e400e781cdb876ba350b3ec8991e3945f
ToppCell	5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	EPHB3 SPINT2 MUC5B DNAH14	1.58e-04	161	75	4	7c9d4410d7142a5f3a05418c994f69978c9ffa17
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal--glomerular_mesenchymal_cell-Renin-positive_Juxtaglomerular_Granular_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	LGI2 DGKG REN PLCE1	1.61e-04	162	75	4	c7114e24cb5525abb9780ca3d35dbcc4eabd4b64
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal--glomerular_mesenchymal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	LGI2 DGKG REN PLCE1	1.61e-04	162	75	4	f1851a173d3bcca2981d934161ec85d1cc0af5a2
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	LGI2 DGKG REN PLCE1	1.61e-04	162	75	4	5d902bb31e691aea9749617cc88303c2448f24b8
ToppCell	3'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-bronchial_goblet_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	RDH10 SV2C MUC5B DNAH14	1.69e-04	164	75	4	c5bfae7e9497185548c243d6f9ebadbcef48ba7f
ToppCell	3'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-bronchial_goblet_cell-Goblet_(bronchial)-Goblet_(bronchial)_L.0.4.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	RDH10 SV2C MUC5B DNAH14	1.69e-04	164	75	4	76b0ac220b7ca22fbea28a507f01f96ae9f53932
ToppCell	3'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-bronchial_goblet_cell-Goblet_(bronchial)\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	RDH10 SV2C MUC5B DNAH14	1.69e-04	164	75	4	911081739174ec68bc0893c804e4276b206bea7d
ToppCell	normal_Lung-Epithelial_cells-Undetermined\|normal_Lung / Location, Cell class and cell subclass	HHIP SPINT2 C4BPA TMEM151A	1.69e-04	164	75	4	fa2dae15b38cb8f9642dbf00549beec8ee19e9bb
ToppCell	PND14-Epithelial-Epithelial_Airway-Neurosecretory\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SPINT2 HP ELAPOR1 MUC5B	1.73e-04	165	75	4	6fdce8b23736409a23884ef3918638ffc067a86f
ToppCell	PND14-Epithelial-Epithelial_Airway-Neurosecretory-Secretory\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SPINT2 HP ELAPOR1 MUC5B	1.73e-04	165	75	4	dd4d36ff8efb89fee1fb4c48d1b8f46902119909
ToppCell	PND14-Epithelial-Epithelial_Airway-Neurosecretory-Secretory-Secretory_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SPINT2 HP ELAPOR1 MUC5B	1.73e-04	165	75	4	baff639a7046fb5cacb70f341b6d24cef3519f8e
ToppCell	5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	RALGPS1 ELAPOR1 MUC5B GPC6	1.77e-04	166	75	4	60060b03f2abfa3cc08107ab5a9f578e60e4ae16
ToppCell	5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	RALGPS1 ELAPOR1 MUC5B GPC6	1.77e-04	166	75	4	ec9161d388db5a257b8d125c14f9dd911d5d5d4a
Drug	benzamil	SPINT2 ASIC1 PKHD1 MTR REN	3.73e-06	72	74	5	CID000108107
Disease	hereditary breast ovarian cancer syndrome (is_implicated_in)	BRCA2 PALB2	6.01e-05	5	73	2	DOID:5683 (is_implicated_in)
Disease	Pancreatic carcinoma, familial	BRCA2 PALB2	2.15e-04	9	73	2	C2931038
Disease	cystic kidney disease (implicated_via_orthology)	EPHB4 SLIT2	2.68e-04	10	73	2	DOID:2975 (implicated_via_orthology)
Disease	smoking status measurement, forced expiratory volume	PKHD1 DGKG	3.27e-04	11	73	2	EFO_0004314, EFO_0006527
Disease	phenylacetylglutamine measurement	SV2B RBBP8	3.92e-04	12	73	2	EFO_0021013
Disease	Amino Acid Metabolism, Inherited Disorders	PSPH PRODH	4.63e-04	13	73	2	C0750905
Disease	Amino Acid Metabolism, Inborn Errors	PSPH PRODH	4.63e-04	13	73	2	C0002514
Disease	Benign tumor of pancreas	BRCA2 RBBP8	4.63e-04	13	73	2	C0347284
Disease	Fanconi anemia	BRCA2 PALB2	5.39e-04	14	73	2	cv:C0015625
Disease	Kartagener syndrome (implicated_via_orthology)	SLIT2 ODAD2	5.39e-04	14	73	2	DOID:0050144 (implicated_via_orthology)
Disease	Hereditary Breast and Ovarian Cancer Syndrome	BRCA2 PALB2	5.39e-04	14	73	2	C0677776
Disease	carotid artery intima media thickness	RBBP8 DGKG ODAD2 GPC6 VWDE PRODH	8.75e-04	450	73	6	EFO_0007117
Disease	Bone marrow hypocellularity	BRCA2 PALB2	9.00e-04	18	73	2	C1855710
Disease	Feeding difficulties	RARS1 MSL3	9.00e-04	18	73	2	C0232466
Disease	Hereditary Non-Polyposis Colon Cancer Type 2	XRCC4 PALB2	1.00e-03	19	73	2	C1333991
Disease	Pancreatic carcinoma	BRCA2 RBBP8	1.00e-03	19	73	2	C0235974
Disease	Colorectal cancer, hereditary nonpolyposis, type 1	XRCC4 PALB2	1.00e-03	19	73	2	C2936783
Disease	Adenocarcinoma of prostate	BRCA2 PALB2	1.11e-03	20	73	2	C0007112
Disease	Bipolar Disorder	BRCA2 MTR REN TDO2 PALB2 PRODH	1.18e-03	477	73	6	C0005586
Disease	X-12063 measurement	EPHB4 SV2A UNC13C DNAH14	1.19e-03	186	73	4	EFO_0021283
Disease	Drug toxicity	HP MTR REN	1.20e-03	84	73	3	C0013221
Disease	Adverse reaction to drug	HP MTR REN	1.20e-03	84	73	3	C0041755
Disease	visceral adipose tissue measurement	SLIT2 PKHD1 DGKG SV2C GPC6 ZZEF1	1.23e-03	481	73	6	EFO_0004765
Disease	Malignant neoplasm of breast	EPHB4 BRCA2 HP ELAPOR1 MTR DGKG USP54 PALB2 PRODH	1.30e-03	1074	73	9	C0006142
Disease	Seckel syndrome	RBBP8 XRCC4	1.35e-03	22	73	2	C0265202
Disease	insular cortex volume measurement	SLIT2 LOXHD1	1.48e-03	23	73	2	EFO_0010309
Disease	Fanconi Anemia	BRCA2 PALB2	1.75e-03	25	73	2	C0015625
Disease	Pancytopenia	BRCA2 PALB2	1.89e-03	26	73	2	C0030312
Disease	Hereditary Nonpolyposis Colorectal Neoplasms	XRCC4 PALB2	1.89e-03	26	73	2	C0009405
Disease	myeloperoxidase measurement	MED22 SIRPB2	1.89e-03	26	73	2	EFO_0005243
Disease	Pancreatic Neoplasm	BRCA2 RBBP8 PALB2	1.98e-03	100	73	3	C0030297
Disease	Hereditary non-polyposis colorectal cancer syndrome	XRCC4 PALB2	2.04e-03	27	73	2	C1112155
Disease	Malignant tumor of breast	BRCA2 PALB2	2.04e-03	27	73	2	cv:C0006142
Disease	Breast neoplasm	BRCA2 PALB2	2.04e-03	27	73	2	cv:C1458155
Disease	Familial cancer of breast	BRCA2 PALB2	2.04e-03	27	73	2	cv:C0346153
Disease	neutrophil count	LGI2 RBBP8 NUP210L MED22 NAIP ELAPOR1 DGKG UNC13C PSPH PRODH	2.08e-03	1382	73	10	EFO_0004833
Disease	Malignant neoplasm of pancreas	BRCA2 RBBP8 PALB2	2.09e-03	102	73	3	C0346647
Disease	primary biliary cholangitis (biomarker_via_orthology)	HHIP REN	2.19e-03	28	73	2	DOID:12236 (biomarker_via_orthology)
Disease	Miller Dieker syndrome	BRCA2 PALB2	2.35e-03	29	73	2	C0265219
Disease	Hereditary Nonpolyposis Colorectal Cancer	XRCC4 PALB2	2.35e-03	29	73	2	C1333990

Protein segments in the cluster

Peptide	Gene	Start	Entry
QYADIISKDFASYCS	UNC13A	1231	Q9UPW8
ASAYCNDSIFAYEEL	NAIP	266	Q13075
SSYSFFKEEIIYECD	C4BPA	441	P04003
DYTSFLEAKIASCFD	EXOC3L4	381	Q17RC7
LKDYDYTCFVFSDVD	B4GALT1	236	P15291
STDKFKTDFYDQCND	COPS6	271	Q7L5N1
YESCLADSFSQAADE	RBBP8	736	Q99708
KYYAKASECIEDFNT	BRDT	86	Q58F21
KAFYSVNGSVYCEED	AJUBA	376	Q96IF1
DSTKYYEACVNDACA	MUC5B	1101	Q9HC84
SNESFISADCTDADY	PDZRN3	621	Q9UPQ7
SCDYASKSYDAVVFD	RALGPS1	31	Q5JS13
CDTYTPAAFAAKDAF	LTN1	156	O94822
SDSSVSFICDVAYNY	LTN1	816	O94822
SFICDVAYNYFSSAK	LTN1	821	O94822
SYFSQKAFACAEEDD	DSG3	791	P32926
VFENYEASKAYSSVD	MGAT4C	351	Q9UBM8
SFDKSCAVAEYGVYV	HP	376	P00738
TYDAASYICEAAFDE	TMPO	621	P42166
SCKETFTVFYYESDA	EPHB4	106	P54760
EEEYYSSSSSLCEAN	MED22	131	Q15528
TDKDYFYTHTACDAN	ELAPOR1	331	Q6UXG2
FYEKEYTGDRSSNCS	LOXHD1	1371	Q8IVV2
VTNYEASLKTCDFFS	NAA16	346	Q6N069
ESAYVAACEAHYSTK	MSL3	501	Q8N5Y2
YKDFDTLLYTCAAEF	DPY19L1	381	Q2PZI1
CKETFNLFYYEADSD	EPHB3	126	P54753
IDDSYQASVCHKAYS	PALB2	1051	Q86YC2
YFEFGTSETFAATCK	DGKG	616	P49619
HFSEDYLECVSKYTD	GPC6	181	Q9Y625
VCSTYSKDSENYFET	BRCA2	2211	P51587
AAATSDFYKRETNCD	COLCA2	136	A8K830
CDFEDSFYLDTQSEK	POLQ	1316	O75417
ENDAACYIDSFKSRY	POLQ	2406	O75417
GTYYECAASEFASVD	CALHM4	126	Q5JW98
KAYSHYQDCFSDSQS	DNAH14	891	Q0VDD8
YVEKYNTSDDCSSSE	KIAA1210	856	Q9ULL0
TEFSACSAYKFNSET	ENC1	501	O14682
CLFDTYVEDAFKSDD	NTAQ1	106	Q96HA8
NECDKYLESSATFAA	NUP210L	636	Q5VU65
IYELATAFTEFYDSC	RARS1	601	P54136
TAFTEFYDSCYCVEK	RARS1	606	P54136
KTGCQITFDDDYSAY	SV2C	566	Q496J9
ECYFEDVTSTDTYFK	SV2B	476	Q7L1I2
TAEYCDSSYFSSDES	TDO2	391	P48775
NDVTSFDYECTTTDF	LGI2	206	Q8N0V4
FFSDASDEAALYAAC	NFATC4	181	Q14934
VYSGDSFCRKDFTDS	PLCE1	276	Q9P212
ESIEYTSDYEFSNGC	ODAD2	221	Q5T2S8
YTACVYHKLFDASDS	REN	121	P00797
KDSASTEPYYCLSDF	MTR	1071	Q99707
SARTYFYANEAKCDS	PRODH	196	O43272
ASDFTVKEDLYTCYE	PKHD1	831	P08F94
QDVTFSSFVKSCYSD	PKHD1	3276	P08F94
TKCFSFGSAEAEASY	TMEM151A	221	Q8N4L1
LFSTAGVEDYCASKF	RDH10	201	Q8IZV5
QTTADEFCFYYARKD	HHIP	161	Q96QV1
FEECYFEDVTSSNTF	SV2A	531	Q7L0J3
DSDLDFFDSYSITAC	ASIC1	296	P78348
NTSLDAASEYAKYCS	NLN	591	Q9BYT8
YASSKAAAECFVQSY	TGDS	166	O95455
FSSYDCSDSYDKAPE	VWDE	911	Q8N2E2
NVSSEDAGTYYCVKF	SIRPB2	231	Q5JXA9
SDFSKLCQSYSEDFS	UNC13C	551	Q8NB66
FYSADAVCFDVDSTV	PSPH	11	P78330
CGDYDSFFESKESNT	SH3BGRL2	76	Q9UJC5
DHSSDMFNYEEYCTA	SPINT2	121	O43291
ADVYTFNFSKESCYF	XRCC4	81	Q13426
KYSFECTDGSSFVDE	SLIT2	1501	O94813
KDSVQESDSAVYFCA	TRAV9-1	96	A0A075B6T8
SASSYYSQDDNCALE	SUCO	36	Q9UBS9
YEYTAFDFCQASEGK	TM9SF2	76	Q99805
KSFEYSDCEEAFVDQ	ZNF121	86	P58317
QTYYAAFAAELEACA	UBR3	566	Q6ZT12
VFAYNSSSDKFCAEE	ZZEF1	601	O43149
YKCDDFDEAFSQASS	ZNF860	566	A6NHJ4
CEYCEYSTTDASGFK	ZNF711	706	Q9Y462
SSFEVYVDTDAKDFA	TCTN2	261	Q96GX1
GDRVYKNECAFSYDS	USP13	41	Q92995
AEYAEFCNSYSKDRG	TTLL5	161	Q6EMB2
AEFQSYSRTCYDSED	USP54	366	Q70EL1